![Ian Brewis](https://profiles-cardiff.imgix.net/attachments/7950?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Overview
My main role at Cardiff involves research infrastructure and core facilities management (0.9 full-time equivalent, FTE). I also have some teaching and teaching management responsibilities (0.1 FTE).
I am the School of Medicine Research Infrastructure Oversight Group (RIOG) Academic Lead/Chair and have a range of research infrastructure management responsibilities at School and College level. Beyond Cardiff I am the GW4* Research Infrastructure and Sustainability Steering Group (RISSG) Cardiff University Technical Leadership Representative, former Chair and a Founder Member of the Group. I am also a CTLS** Executive Council Member, Training Working Group Member and the former Shadowing and Staff Exchange Focus Group Lead.
*The GW4 Alliance is a collaborative research partnership between Bath, Bristol, Cardiff and Exeter Universities (https://gw4.ac.uk/).
**Core Technologies for Life Sciences (CTLS) is a pan-European networking association for those working in core facilities, research infrastructures and other shared resource laboratories (https://ctls-org.eu/)
I have been Central Biotechnology Services (CBS) Operational Director since Dec 2011. CBS (https://www.cardiff.ac.uk/central-biotechnology-services) is an ISO 9001:2015 certified and Good Clinical Laboratory Practice (GCLP) accredited Cardiff University Core Technology Facility. Based in the School of Medicine CBS provides gene expression and bioinformatics, proteins and diagnostics and cell analysis/imaging platforms, services, training and expertise to local researchers and external organisations. CBS also offers opportunities for hosting companies and can provide laboratory facilities, technological support, academic consultancy and access to a wide range of other university resources. Options for contract research and managed services are backed up by a proven track record of working with not-for-profit organisations, start-ups, SMEs and large businesses.
Please see the Teaching section for my teaching/teaching management responsibilities.
Publication
2021
- Alsagaby, S. A. et al. 2021. Proteomics-based identification of cancer-associated proteins in chronic lymphocytic leukaemia. Electronic Journal of Biotechnology 52, pp. 1-12. (10.1016/j.ejbt.2021.04.006)
2017
- Brewis, I., Watkinson, M. and Von Ruhland, C. 2017. Heads you win, tails you lose: filtration processing for the microscopical examination of sperm heads. Journal of Microscopy 265(3), pp. 335-340. (10.1111/jmi.12505)
2016
- Webber, J. P., Spary, L. K., Mason, M. D., Tabi, Z., Brewis, I. A. and Clayton, A. 2016. Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget 7, pp. 20124-20139. (10.18632/oncotarget.7716)
2014
- Webber, J. et al. 2014. Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscanTM) platform. Molecular and Cellular Proteomics 13(4), pp. 1050-1064. (10.1074/mcp.M113.032136)
- Alsagaby, S. A. et al. 2014. Proteomics-based strategies to identify proteins relevant to chronic lymphocytic leukemia. Journal of Proteome Research 13(11), pp. 5051-5062. (10.1021/pr5002803)
2012
- Hoogendoorn, B. et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600)
- Tsai, P. J., Brewis, I. A., van Maaren, J. and Gadella, B. M. 2012. Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis. Plos One 7(3), article number: e32603. (10.1371/journal.pone.0032603)
2011
- Sexton, K. J., Balharry, D. C., Brennan, P., McLaren, J. E., Brewis, I. A. and Berube, K. A. 2011. Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Biomarkers 16(7), pp. 567-576. (10.3109/1354750X.2011.608855)
2010
- Welton, J. L. et al. 2010. Proteomics analysis of bladder cancer exosomes. Molecular & Cellular Proteomics 9(6), pp. 1324-1338. (10.1074/mcp.M000063-MCP201)
- Brewis, I. and Brennan, P. 2010. Proteomics technologies for the global identification and quantification of proteins. In: Donev, R. ed. Advances in Protein Chemistry and Structural Biology., Vol. 80. Elsevier, pp. 1-44., (10.1016/B978-0-12-381264-3.00001-1)
- Alnagar, F., Brennan, P. and Brewis, I. A. 2010. Bicarbonate-dependent serine/threonine protein dephosphorylation in capacitating boar spermatozoa. Journal of Andrology 31(4), pp. 393-405. (10.2164/jandrol.109.008383)
- Brewis, I. A. and Topley, N. 2010. Proteomics and peritoneal dialysis: early days but clear potential. Nephrology Dialysis Transplantation 25(6), pp. 1749-1753. (10.1093/ndt/gfq145)
2009
- Brennan, P. et al. 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3(3), pp. 359-369. (10.1002/prca.200800137)
2007
- Brewis, I. A., Gadella, B., Ashton, P. R. and Gestel, R. A. v. 2007. Multiple proteins present in purified porcine sperm apical plasma membranes interact with the zona pellucida of the oocyte. Molecular Human Reproduction 13(7), pp. 445-454. (10.1093/molehr/gam030)
- Brewis, I. A. 2007. Protein chips and disease biomarkers. Plasma Protein Monitor 1, pp. 47-48.
- Brewis, I. A. 2007. The way forward for clinical proteomics. Plasma Protein Monitor 1, pp. 55-56.
- Connor, S. J. et al. 2007. Understanding the physiology of pre-fertilisation events in the human spermatozoa - a necessary prerequisite to developing rational therapy. Society of Reproduction and Fertility Supplement 63, pp. 237-255.
2006
- Brewis, I. A. 2006. The human plasma proteome. Plasma Protein Monitor 1, pp. 39-40.
2005
- Brewis, I. A., Gadella, B. M., Ashton, P. R. and Gestal, R. A. v. 2005. Capacitation-dependent concentration of lipid rafts in the apical ridge head area of porcine sperm cells. Molecular Human Reproduction 11(8), pp. 583-590. (10.1093/molehr/gah200)
- Moseley, F. L. C., Jha, K. N., Björndahl, L., Brewis, I. A., Publicover, S. J., Barratt, C. L. R. and Lefièvre, L. 2005. Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation. Molecular Human Reproduction 11(7), pp. 523-529. (10.1093/molehr/gah188)
- Brewis, I. A. 2005. Proteomics – possibilities and pitfalls. Plasma Protein Monitor 1, pp. 22-23.
- Brewis, I. A. et al. 2005. Molecular mechanisms during sperm capacitation. Human Fertility 8(4), pp. 253-261. (10.1080/14647270500420178)
- Brewis, I. A. et al. 2005. The spermatozoon at fertilisation: Current understanding and future research directions. Human Fertility 8(4), pp. 241-251. (10.1080/14647270500420160)
2004
- Kilani, Z., Ismail, R., Ghunaim, S., Mohamed, H., Hughes, D., Brewis, I. A. and Barratt, C. L. R. 2004. Evaluation and treatment of familial globozoospermia in five brothers. Fertility and Sterility 82(5), pp. 1436-1439. (10.1016/j.fertnstert.2004.03.064)
- Brewis, I. A., Barratt, C., Deeks, E. D. and Flesch, F. M. 2004. Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least 20 proteins compared with fertile donors: case report. Human Reproduction 19(6), pp. 1438-1447. (10.1093/humrep/deh224)
- Lefievre, L. et al. 2004. Four zona pellucida glycoproteins are expressed in the human. Human Reproduction 19(7), pp. 1580-1586. (10.1093/humrep/deh301)
2003
- Lefièvre, L. et al. 2003. Physiological and proteomic approaches to studying prefertilization events in the human. Reproductive BioMedicine Online 7(4), pp. 419-427. (10.1016/S1472-6483(10)61885-8)
2002
- Ivic, A. et al. 2002. Critical evaluation of methylcellulose as an alternative medium in sperm migration tests. Human Reproduction 17(1), pp. 143-149. (10.1093/humrep/17.1.143)
- Barratt, C. L., Hughes, D. C., Afnan, M. and Brewis, I. A. 2002. Functional genomics in reproductive medicine. Human Fertility 5(1), pp. 3-5., article number: 10.1080/1464727992000199681.
2001
- Brewis, I. A., England, G. C. W., Moore, H. D. M. and Morton, I. E. 2001. Solubilized zona pellucida proteins and progesterone induce calcium influx and the acrosome reaction in capacitated dog spermatozoa. Molecular Reproduction and Development 60(4), pp. 491-497. (10.1002/mrd.1114)
- Hosseinzadeh, S., Brewis, I. A., Eley, A. and Pacey, A. A. 2001. Co-incubation of human spermatozoa with Chlamydia trachomatis serovar E causes premature sperm death. Human Reproduction 16(2), pp. 293-299. (10.1093/humrep/16.2.293)
2000
- Hosseinzadeh, S., Brewis, I. A., Pacey, A. A., Moore, H. D. M. and Eley, A. 2000. Coincubation of human spermatozoa with chlamydia trachomatis in vitro causes increased tyrosine phosphorylation of sperm proteins. Infection and Immunity 68(9), pp. 4872-4876. (10.1128/IAI.68.9.4872-4876.2000)
- Brewis, I., Morton, I. E., Mohammad, S. N., Browes, C. E. and Moore, H. D. 2000. Measurement of intracellular calcium concentration and plasma membrane potential in human spermatozoa using flow cytometry. Journal of Andrology 21(2), pp. 238-249. (10.1002/j.1939-4640.2000.tb02101.x)
1999
- Brewis, I. A. and Wong, C. H. 1999. Gamete recognition: sperm proteins that interact with the egg zona pellucida. Reproduction 4(3), pp. 135-142. (10.1530/ror.0.0040135)
- Brewis, I. A. 1999. Proteomics in reproductive research: The potential importance of proteomics to research in reproduction. Human Reproduction 14(12), pp. 2927-2929. (10.1093/humrep/14.12.2927)
1998
- Moore, H. D., Samayawardhena, L. A. and Brewis, I. A. 1998. Sperm maturation in vitro: co-culture of spermatozoa and epididymal epithelium. Journal of Reproduction and Fertility. Supplement 53, pp. 23-31.
- Fisher, H. M., Brewis, I. A., Barratt, C. L., Cooke, I. D. and Moore, H. D. 1998. Phosphoinositide 3-kinase is involved in the induction of the human sperm acrosome reaction downstream of tyrosine phosphorylation. Molecular Human Reproduction 4(9), pp. 849-855. (10.1093/molehr/4.9.849)
- Brewis, I. A. 1998. Tyrosine phosphorylation of a 95 kDa protein and induction of the acrosome reaction in human spermatozoa by recombinant human zona pellucida glycoprotein 3. Molecular Human Reproduction 4(12), pp. 1136-1144. (10.1093/molehr/4.12.1136)
1997
- Brewis, I. A. and Moore, H. D. 1997. Molecular mechanisms of gamete recognition and fusion at fertilization. Human Reproduction 12(Sup.), pp. 156-165.
1996
- Brewis, I. A., Clayton, R., Barratt, C. L. R., Hornby, D. P. J. and Moore, H. D. M. 1996. Recombinant human zona pellucida glycoprotein 3 induces calcium influx and acrosome reaction in human spermatozoa. Molecular Human Reproduction 2(8), pp. 583-589. (10.1093/molehr/2.8.583)
1995
- Brewis, I. A., Ferguson, M. A. J., Mehlert, A., Turner, A. J. and Hooper, N. M. 1995. Structures of the glycosyl-phosphatidylinositol anchors of porcine and human renal membrane dipeptidase: comprehensive structural studies on the porcine anchor and interspecies comparison of the glycan core structures. Journal of Biological Chemistry 270(39), pp. 22946-22956. (10.1074/jbc.270.39.22946)
1994
- Brewis, I. A., Turner, A. J. and Hooper, N. M. 1994. Activation of the glycosyl-phosphatidylinositol-anchored membrane dipeptidase upon release from pig kidney membranes by phospholipase C. Biochemical Journal -London- 303, pp. 633-638.
- Leese, H. J., Brewis, I. A., Edwards, L. I., Gray, S. M., Skiera, L. S. and Winston, R. M. L. 1994. Biochemistry of tubal secretions. In: Grudzinskas, J. G. et al. eds. The Fallopian Tube: clinical and surgical aspects. London: Springer, pp. 53-62.
1993
- Howell, S., Brewis, I. A., Hooper, N. M., Kenny, A. J. and Turner, A. J. 1993. Mosaic expression of membrane peptidases by confluent cultures of Caco-2 cells. FEBS Letters 317(1-2), pp. 109-112. (10.1016/0014-5793(93)81502-Q)
- Brewis, I. A., Ferguson, M. A., Turner, A. J. and Hooper, N. M. 1993. Structural determination of the glycolipid anchors of human and porcine membrane dipeptidases. Biochemical Society Transactions 21(1), pp. 46S-46S. (10.1042/bst021046s)
- Brewis, I., Howell, S., Hooper, N. M., Kenny, A. J. and Turner, A. J. 1993. Membrane peptidase expression by confluent cultures of Caco-2 cells. Biochemical Society Transactions 21, pp. 252S-252S. (10.1042/bst021252s)
- Brewis, I. A., Hooper, N. M. and Turner, A. J. 1993. Identification of the site of attachment of the glycolipid anchor in porcine membrane dipeptidase. Biochemical Society Transactions 21, pp. 44S-44S. (10.1042/bst021044s)
1992
- Brewis, I. A., Winston, R. M. L. and Leese, H. J. 1992. Energy metabolism of the human Fallopian tube. Reproduction 95(1), pp. 257-262. (10.1530/jrf.0.0950257)
Adrannau llyfrau
- Brewis, I. and Brennan, P. 2010. Proteomics technologies for the global identification and quantification of proteins. In: Donev, R. ed. Advances in Protein Chemistry and Structural Biology., Vol. 80. Elsevier, pp. 1-44., (10.1016/B978-0-12-381264-3.00001-1)
- Leese, H. J., Brewis, I. A., Edwards, L. I., Gray, S. M., Skiera, L. S. and Winston, R. M. L. 1994. Biochemistry of tubal secretions. In: Grudzinskas, J. G. et al. eds. The Fallopian Tube: clinical and surgical aspects. London: Springer, pp. 53-62.
Erthyglau
- Alsagaby, S. A. et al. 2021. Proteomics-based identification of cancer-associated proteins in chronic lymphocytic leukaemia. Electronic Journal of Biotechnology 52, pp. 1-12. (10.1016/j.ejbt.2021.04.006)
- Brewis, I., Watkinson, M. and Von Ruhland, C. 2017. Heads you win, tails you lose: filtration processing for the microscopical examination of sperm heads. Journal of Microscopy 265(3), pp. 335-340. (10.1111/jmi.12505)
- Webber, J. P., Spary, L. K., Mason, M. D., Tabi, Z., Brewis, I. A. and Clayton, A. 2016. Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget 7, pp. 20124-20139. (10.18632/oncotarget.7716)
- Webber, J. et al. 2014. Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscanTM) platform. Molecular and Cellular Proteomics 13(4), pp. 1050-1064. (10.1074/mcp.M113.032136)
- Alsagaby, S. A. et al. 2014. Proteomics-based strategies to identify proteins relevant to chronic lymphocytic leukemia. Journal of Proteome Research 13(11), pp. 5051-5062. (10.1021/pr5002803)
- Hoogendoorn, B. et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600)
- Tsai, P. J., Brewis, I. A., van Maaren, J. and Gadella, B. M. 2012. Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis. Plos One 7(3), article number: e32603. (10.1371/journal.pone.0032603)
- Sexton, K. J., Balharry, D. C., Brennan, P., McLaren, J. E., Brewis, I. A. and Berube, K. A. 2011. Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Biomarkers 16(7), pp. 567-576. (10.3109/1354750X.2011.608855)
- Welton, J. L. et al. 2010. Proteomics analysis of bladder cancer exosomes. Molecular & Cellular Proteomics 9(6), pp. 1324-1338. (10.1074/mcp.M000063-MCP201)
- Alnagar, F., Brennan, P. and Brewis, I. A. 2010. Bicarbonate-dependent serine/threonine protein dephosphorylation in capacitating boar spermatozoa. Journal of Andrology 31(4), pp. 393-405. (10.2164/jandrol.109.008383)
- Brewis, I. A. and Topley, N. 2010. Proteomics and peritoneal dialysis: early days but clear potential. Nephrology Dialysis Transplantation 25(6), pp. 1749-1753. (10.1093/ndt/gfq145)
- Brennan, P. et al. 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3(3), pp. 359-369. (10.1002/prca.200800137)
- Brewis, I. A., Gadella, B., Ashton, P. R. and Gestel, R. A. v. 2007. Multiple proteins present in purified porcine sperm apical plasma membranes interact with the zona pellucida of the oocyte. Molecular Human Reproduction 13(7), pp. 445-454. (10.1093/molehr/gam030)
- Brewis, I. A. 2007. Protein chips and disease biomarkers. Plasma Protein Monitor 1, pp. 47-48.
- Brewis, I. A. 2007. The way forward for clinical proteomics. Plasma Protein Monitor 1, pp. 55-56.
- Connor, S. J. et al. 2007. Understanding the physiology of pre-fertilisation events in the human spermatozoa - a necessary prerequisite to developing rational therapy. Society of Reproduction and Fertility Supplement 63, pp. 237-255.
- Brewis, I. A. 2006. The human plasma proteome. Plasma Protein Monitor 1, pp. 39-40.
- Brewis, I. A., Gadella, B. M., Ashton, P. R. and Gestal, R. A. v. 2005. Capacitation-dependent concentration of lipid rafts in the apical ridge head area of porcine sperm cells. Molecular Human Reproduction 11(8), pp. 583-590. (10.1093/molehr/gah200)
- Moseley, F. L. C., Jha, K. N., Björndahl, L., Brewis, I. A., Publicover, S. J., Barratt, C. L. R. and Lefièvre, L. 2005. Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation. Molecular Human Reproduction 11(7), pp. 523-529. (10.1093/molehr/gah188)
- Brewis, I. A. 2005. Proteomics – possibilities and pitfalls. Plasma Protein Monitor 1, pp. 22-23.
- Brewis, I. A. et al. 2005. Molecular mechanisms during sperm capacitation. Human Fertility 8(4), pp. 253-261. (10.1080/14647270500420178)
- Brewis, I. A. et al. 2005. The spermatozoon at fertilisation: Current understanding and future research directions. Human Fertility 8(4), pp. 241-251. (10.1080/14647270500420160)
- Kilani, Z., Ismail, R., Ghunaim, S., Mohamed, H., Hughes, D., Brewis, I. A. and Barratt, C. L. R. 2004. Evaluation and treatment of familial globozoospermia in five brothers. Fertility and Sterility 82(5), pp. 1436-1439. (10.1016/j.fertnstert.2004.03.064)
- Brewis, I. A., Barratt, C., Deeks, E. D. and Flesch, F. M. 2004. Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least 20 proteins compared with fertile donors: case report. Human Reproduction 19(6), pp. 1438-1447. (10.1093/humrep/deh224)
- Lefievre, L. et al. 2004. Four zona pellucida glycoproteins are expressed in the human. Human Reproduction 19(7), pp. 1580-1586. (10.1093/humrep/deh301)
- Lefièvre, L. et al. 2003. Physiological and proteomic approaches to studying prefertilization events in the human. Reproductive BioMedicine Online 7(4), pp. 419-427. (10.1016/S1472-6483(10)61885-8)
- Ivic, A. et al. 2002. Critical evaluation of methylcellulose as an alternative medium in sperm migration tests. Human Reproduction 17(1), pp. 143-149. (10.1093/humrep/17.1.143)
- Barratt, C. L., Hughes, D. C., Afnan, M. and Brewis, I. A. 2002. Functional genomics in reproductive medicine. Human Fertility 5(1), pp. 3-5., article number: 10.1080/1464727992000199681.
- Brewis, I. A., England, G. C. W., Moore, H. D. M. and Morton, I. E. 2001. Solubilized zona pellucida proteins and progesterone induce calcium influx and the acrosome reaction in capacitated dog spermatozoa. Molecular Reproduction and Development 60(4), pp. 491-497. (10.1002/mrd.1114)
- Hosseinzadeh, S., Brewis, I. A., Eley, A. and Pacey, A. A. 2001. Co-incubation of human spermatozoa with Chlamydia trachomatis serovar E causes premature sperm death. Human Reproduction 16(2), pp. 293-299. (10.1093/humrep/16.2.293)
- Hosseinzadeh, S., Brewis, I. A., Pacey, A. A., Moore, H. D. M. and Eley, A. 2000. Coincubation of human spermatozoa with chlamydia trachomatis in vitro causes increased tyrosine phosphorylation of sperm proteins. Infection and Immunity 68(9), pp. 4872-4876. (10.1128/IAI.68.9.4872-4876.2000)
- Brewis, I., Morton, I. E., Mohammad, S. N., Browes, C. E. and Moore, H. D. 2000. Measurement of intracellular calcium concentration and plasma membrane potential in human spermatozoa using flow cytometry. Journal of Andrology 21(2), pp. 238-249. (10.1002/j.1939-4640.2000.tb02101.x)
- Brewis, I. A. and Wong, C. H. 1999. Gamete recognition: sperm proteins that interact with the egg zona pellucida. Reproduction 4(3), pp. 135-142. (10.1530/ror.0.0040135)
- Brewis, I. A. 1999. Proteomics in reproductive research: The potential importance of proteomics to research in reproduction. Human Reproduction 14(12), pp. 2927-2929. (10.1093/humrep/14.12.2927)
- Moore, H. D., Samayawardhena, L. A. and Brewis, I. A. 1998. Sperm maturation in vitro: co-culture of spermatozoa and epididymal epithelium. Journal of Reproduction and Fertility. Supplement 53, pp. 23-31.
- Fisher, H. M., Brewis, I. A., Barratt, C. L., Cooke, I. D. and Moore, H. D. 1998. Phosphoinositide 3-kinase is involved in the induction of the human sperm acrosome reaction downstream of tyrosine phosphorylation. Molecular Human Reproduction 4(9), pp. 849-855. (10.1093/molehr/4.9.849)
- Brewis, I. A. 1998. Tyrosine phosphorylation of a 95 kDa protein and induction of the acrosome reaction in human spermatozoa by recombinant human zona pellucida glycoprotein 3. Molecular Human Reproduction 4(12), pp. 1136-1144. (10.1093/molehr/4.12.1136)
- Brewis, I. A. and Moore, H. D. 1997. Molecular mechanisms of gamete recognition and fusion at fertilization. Human Reproduction 12(Sup.), pp. 156-165.
- Brewis, I. A., Clayton, R., Barratt, C. L. R., Hornby, D. P. J. and Moore, H. D. M. 1996. Recombinant human zona pellucida glycoprotein 3 induces calcium influx and acrosome reaction in human spermatozoa. Molecular Human Reproduction 2(8), pp. 583-589. (10.1093/molehr/2.8.583)
- Brewis, I. A., Ferguson, M. A. J., Mehlert, A., Turner, A. J. and Hooper, N. M. 1995. Structures of the glycosyl-phosphatidylinositol anchors of porcine and human renal membrane dipeptidase: comprehensive structural studies on the porcine anchor and interspecies comparison of the glycan core structures. Journal of Biological Chemistry 270(39), pp. 22946-22956. (10.1074/jbc.270.39.22946)
- Brewis, I. A., Turner, A. J. and Hooper, N. M. 1994. Activation of the glycosyl-phosphatidylinositol-anchored membrane dipeptidase upon release from pig kidney membranes by phospholipase C. Biochemical Journal -London- 303, pp. 633-638.
- Howell, S., Brewis, I. A., Hooper, N. M., Kenny, A. J. and Turner, A. J. 1993. Mosaic expression of membrane peptidases by confluent cultures of Caco-2 cells. FEBS Letters 317(1-2), pp. 109-112. (10.1016/0014-5793(93)81502-Q)
- Brewis, I. A., Ferguson, M. A., Turner, A. J. and Hooper, N. M. 1993. Structural determination of the glycolipid anchors of human and porcine membrane dipeptidases. Biochemical Society Transactions 21(1), pp. 46S-46S. (10.1042/bst021046s)
- Brewis, I., Howell, S., Hooper, N. M., Kenny, A. J. and Turner, A. J. 1993. Membrane peptidase expression by confluent cultures of Caco-2 cells. Biochemical Society Transactions 21, pp. 252S-252S. (10.1042/bst021252s)
- Brewis, I. A., Hooper, N. M. and Turner, A. J. 1993. Identification of the site of attachment of the glycolipid anchor in porcine membrane dipeptidase. Biochemical Society Transactions 21, pp. 44S-44S. (10.1042/bst021044s)
- Brewis, I. A., Winston, R. M. L. and Leese, H. J. 1992. Energy metabolism of the human Fallopian tube. Reproduction 95(1), pp. 257-262. (10.1530/jrf.0.0950257)
Research
See Biography section for details of this former activty
Teaching
My main teaching/teaching management roles include being:-
-Former MSc Bioinformatics/Genetic Epidemiology and Bioinformatics Programme Director (2010-2016)
-Module Lead for the MSc Applied Bioinformatics and Genomics (formerly MSc Bioinformatics) Protein Biology and Omics (formerly Protein Bioinformatics) module (since 2004)
-Personal Tutor Lead for the MSc Applied Bioinformatics and Genomics (formerly MSc Bioinformatics) Programme (since 2024) and Personal Tutor (since 2004 and typically 5 students)
-Personal Tutor for MBBCh (C21) medical students (since 2013 and typically 10 students)
-School of Medicine C21 Divisional Teaching Lead for Clinical Innovation (since 2016)
-Postgraduate Research (PGR) Representative for Clinical Innovation (not strictly teaching but included here as it is also an educational activity)(since 2016)
-External Examiner for five Taught Masters Programmes at three Russell Group Universities (2012-2020) and for many research degree theses (13 PhD and 2 MRes theses)
-External Reviewer for four new Masters Programmes (2012-2024) and one new Undergraduate Programme (2025) at two Russell Group Universities
-Associate Lecturer at the Open University (2010-2017 in my own time)
Biography
See the Overview section for my current roles.
I was recruited to Cardiff in 2003 and was tasked with achieving funding to establish and lead a new Proteomics Facility. This was successful and, as CBS Proteomics Facility Academic Lead, I was responsible for a wide range of projects in extended collaborations with many Cardiff researchers and external clients until 2014. I was also the Scientific Director of Ovasort Ltd, who were primarily interested in sperm-based sex-selection in livestock (2005-2009).
I am a former researcher (proteomic and functional characterisation of mammalian sperm cells at fertilization) and was an Associate Editor for two journals: Molecular Human Reproduction (2013-2016) and Reproduction (2013-2023). Before Cardiff I was a Senior Research Fellow at the University of Birmingham and Birmingham NHS Assisted Conception Unit (2000-2003) and a Postdoctoral Research Associate at the University of Sheffield (1993-2000). These varied roles also included a wide range of research projects in mammalian reproduction and several years working on commercial projects.
My PhD (1994) on the biochemistry of mammalian glycolipid anchors was conducted as a Research Assistant at the University of Leeds and also involved spending extended time with collaborators at the University of Dundee. Prior to this I was a Research Assistant at the University of York (1989-1990) where I investigated the biochemistry of the Fallopian tube in collaboration with colleagues at Hammersmith Hospital. Lastly, I also studied for my first degree at the University of York and graduated in 1989 with a BSc (Hons) in Biology (Cell Biology and Biochemistry).
Supervisions
I am not research active so I am not available for supervision
Engagement
See the Overview Section
Contact Details
BrewisIA@cardiff.ac.uk
+44 29206 88648
Henry Wellcome Building for Biomedical Research, Room UG11, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN
+44 29206 88648
Henry Wellcome Building for Biomedical Research, Room UG11, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN
Research themes
Specialisms
- Sustainable research infrastructure and facilities management