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Dr Helen Brown
(hi/ei)
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Helen Brown
Darlithydd - Microbioleg (T & R)
Ysgol y Biowyddorau
Trosolwyg
Mae fy ymchwil yn ymchwilio i sut mae microbau commensal ac amgylcheddol yn trosglwyddo i pathogenau opportunistaidd, gyda ffocws penodol ar facteria anaerobig a microaerobig, ffurfio bioffilm, a dyfalbarhad microbaidd mewn cilfachau cyfaddawdu. Rwy'n gweithio ar draws cyd-destunau clinigol ac amgylcheddol, gan archwilio sut mae cymunedau microbaidd yn cyfrannu at glefydau dynol oportunistaidd. Trwy integreiddio cysyniadau o One Health, bioleg heintiau, a therapiwteg microbiome, rwy'n anelu at ddatgelu mecanweithiau addasu a dyfalbarhad microbaidd sy'n dylanwadu ar iechyd dynol trwy gydol oes.
Rwy'n arwain pedwar llinyn ymchwil rhyng-gysylltiedig:
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Ffurfio bioffilm a dyfalbarhad Campylobacter jejuni
Mae Campylobacter jejuni yn pathogen microaeroffilig ac yn un o brif achosion gastroenteritis bacteriol. Er gwaethaf ei ofynion twf hardidious, mae'n parhau mewn amgylcheddau cadwyn fwyd trwy ffurfio bioffilm ac ymlyniad arwyneb. Mae fy ymchwil yn ymchwilio i sut mae C. jejuni yn ffurfio bioffilmiau o dan amodau aerobig a microaerobig, gyda ffocws penodol ar rôl DNA allgellog (eDNA) mewn strwythur bioffilm, sefydlogrwydd ac ymwrthedd gwrthficrobaidd. -
Cutibacterium acnes fel pathogen oportunistaidd
Mae C. acnes, croen anaerobig, yn gynyddol gysylltiedig â heintiau sy'n gysylltiedig â mewnblaniad a chanser y prostad. Gall y microamgylchedd tiwmor anocsig gefnogi ei wladychu, a gallai llid cysylltiedig yrru cynnydd canser. Rwy'n ymchwilio i ddyfalbarhad microbaidd ac ymatebion gwesteiwr i'r organeb hon sydd heb ei archwilio. -
Gwladychu clwyfau cronig microbaidd
Mae clwyfau cronig yn cael eu gwladychu gan rywogaethau microbaidd amrywiol o'r amgylchedd a microbiom dynol, gan gynnwys anaerobau ac anaerobau facultative. Gan ddefnyddio modelau bioffilm aml-rywogaeth a chyd-ddiwylliant bacterial-mamaliaid, rwy'n astudio sut mae microbau yn integreiddio i gymunedau clwyfau a'r ffactorau sy'n gyrru gordyfiant a haint symptomatig. -
Triniaeth probiotig a chynhyrchion naturiol o heintiau clwyfau
Mae gwrthfiotigau confensiynol yn aml yn methu yn erbyn heintiau clwyfau cronig oherwydd ffurfio bioffilm ac ymwrthedd cynhenid, yn enwedig ymhlith rhywogaethau anaerobig a bioffilm. Rwy'n archwilio potensial gwrthficrobaidd a gwrthbioffilm bwydydd eplesu, probiotegau, a chynhyrchion naturiol fel therapïau amgen ar gyfer bioffilmiau clwyfau cymhleth.
Cyhoeddiad
2026
- Asadpour, A. et al., 2026. Neural crest-derived stem cell secretomes and extracellular vesicles disrupt glioblastoma through dual-pathway inflammatory rebalancing. Stem Cell Reviews and Reports 22 , pp.2528-2548. (10.1007/s12015-026-11133-5)
2025
- Brajdic, L. et al. 2025. Cutibacterium acnes: An emerging prostate cancer pathogen. Biology 15 (1) 30. (10.3390/biology15010030)
- Elfar, M. Y. et al. 2025. Antibiotic carry over is a confounding factor for cell-based antimicrobial research applications. Scientific Reports 15 (1) 28310. (10.1038/s41598-025-14186-7)
- Miles, A. et al. 2025. Direct measurement of non-thermal microwave effects on bacterial growth and redox dynamics using a novel high-throughput waveguide applicator. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 383 (2297) 20240073. (10.1098/rsta.2024.0073)
- Metris, A. et al., 2025. Assessing the safety of microbiome perturbations. Microbial Genomics 11 (5) 001405. (10.1099/mgen.0.001405)
2024
- Brown, H. L. et al. 2024. One health: a structured review and commentary on trends and themes. One Health Outlook 6 (1) 17. (10.1186/s42522-024-00111-x)
2023
- Kempf, F. et al., 2023. Inflammatory responses induced by the monophasic variant of salmonella typhimurium in pigs play a role in the high shedder phenotype and fecal microbiota composition. mSystems 8 (1) e00852-22. (10.1128/msystems.00852-22)
2022
- Abbott, C. et al., 2022. Cutibacterium acnes biofilm forming clinical isolates modify the formation and structure of Staphylococcus aureus biofilms, increasing their susceptibility to antibiotics. Anaerobe 76 102580. (10.1016/j.anaerobe.2022.102580)
- Knight, R. et al. 2022. Oral progenitor cell line-derived small extracellular vesicles as a treatment for preferential wound healing outcome. Stem Cells Translational Medicine 11 (8), pp.861-875. (10.1093/stcltm/szac037)
- Brown, H. L. 2022. Microbial growth. In: Rezaei, N. ed. Encyclopedia of Infection and Immunity. Vol. 1, Elsevier. , pp.324-335. (10.1016/B978-0-12-818731-9.00190-7)
2021
- Brown, H. , Clayton, A. and Stephens, P. 2021. The role of bacterial extracellular vesicles in chronic wound infections: current knowledge and future challenges. Wound Repair and Regeneration 29 (6), pp.864-880. (10.1111/wrr.12949)
2020
- Brown, H. L. et al. 2020. Antibacterial and anti-virulence activity of manuka honey against genetically diverse Staphylococcus pseudintermedius. Applied and Environmental Microbiology 86 e01768-20. (10.1128/AEM.01768-20)
- Brown, H. L. et al. 2020. The One Health European Joint Programme (OHEJP), 2018-2022: an exemplary One Health initiative. Journal of Medical Microbiology 69 (8), pp.1037-1039. (10.1099/jmm.0.001228)
2015
- Jenkins, R. , Roberts, A. and Brown, H. L. 2015. On the antibacterial effects of manuka honey: mechanistic insights. Research and Reports in Biology 6 , pp.215-224. (10.2147/RRB.S75754)
- Reuter, M. et al., 2015. A PAS domain-containing regulator controls flagella-flagella interactions in Campylobacter jejuni. Frontiers in Microbiology 6 770. (10.3389/fmicb.2015.00770)
- Brown, H. L. et al. 2015. Campylobacter jejuni biofilms contain extracellular DNA and are sensitive to DNase I treatment. Frontiers in Microbiology 6 699. (10.3389/fmicb.2015.00699)
- Gerlach, R. G. et al., 2015. Prevention of biofilm formation and removal of existing biofilms by extracellular DNases of Campylobacter jejuni. PLoS ONE 10 (3) e0121680. (10.1371/journal.pone.0121680)
2014
- Brown, H. L. et al. 2014. Chicken juice enhances surface attachment and biofilm formation of Campylobacter jejuni. Applied and Environmental Microbiology 80 (22), pp.7053-7060. (10.1128/AEM.02614-14)
2013
- Marlow, V. L. et al., 2013. Blast a biofilm: a hands-on activity for school children and members of the public. Journal of Microbiology and Biology Education 14 (2), pp.152-254. (10.1128/jmbe.v14i2.563)
- Brown, H. L. et al. 2013. Tetrazolium reduction allows assessment of biofilm formation byCampylobacter jejuniin a food matrix model. Journal of Applied Microbiology 115 (5), pp.1212-1221. (10.1111/jam.12316)
Articles
- Asadpour, A. et al., 2026. Neural crest-derived stem cell secretomes and extracellular vesicles disrupt glioblastoma through dual-pathway inflammatory rebalancing. Stem Cell Reviews and Reports 22 , pp.2528-2548. (10.1007/s12015-026-11133-5)
- Brajdic, L. et al. 2025. Cutibacterium acnes: An emerging prostate cancer pathogen. Biology 15 (1) 30. (10.3390/biology15010030)
- Elfar, M. Y. et al. 2025. Antibiotic carry over is a confounding factor for cell-based antimicrobial research applications. Scientific Reports 15 (1) 28310. (10.1038/s41598-025-14186-7)
- Miles, A. et al. 2025. Direct measurement of non-thermal microwave effects on bacterial growth and redox dynamics using a novel high-throughput waveguide applicator. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 383 (2297) 20240073. (10.1098/rsta.2024.0073)
- Metris, A. et al., 2025. Assessing the safety of microbiome perturbations. Microbial Genomics 11 (5) 001405. (10.1099/mgen.0.001405)
- Brown, H. L. et al. 2024. One health: a structured review and commentary on trends and themes. One Health Outlook 6 (1) 17. (10.1186/s42522-024-00111-x)
- Kempf, F. et al., 2023. Inflammatory responses induced by the monophasic variant of salmonella typhimurium in pigs play a role in the high shedder phenotype and fecal microbiota composition. mSystems 8 (1) e00852-22. (10.1128/msystems.00852-22)
- Abbott, C. et al., 2022. Cutibacterium acnes biofilm forming clinical isolates modify the formation and structure of Staphylococcus aureus biofilms, increasing their susceptibility to antibiotics. Anaerobe 76 102580. (10.1016/j.anaerobe.2022.102580)
- Knight, R. et al. 2022. Oral progenitor cell line-derived small extracellular vesicles as a treatment for preferential wound healing outcome. Stem Cells Translational Medicine 11 (8), pp.861-875. (10.1093/stcltm/szac037)
- Brown, H. , Clayton, A. and Stephens, P. 2021. The role of bacterial extracellular vesicles in chronic wound infections: current knowledge and future challenges. Wound Repair and Regeneration 29 (6), pp.864-880. (10.1111/wrr.12949)
- Brown, H. L. et al. 2020. Antibacterial and anti-virulence activity of manuka honey against genetically diverse Staphylococcus pseudintermedius. Applied and Environmental Microbiology 86 e01768-20. (10.1128/AEM.01768-20)
- Brown, H. L. et al. 2020. The One Health European Joint Programme (OHEJP), 2018-2022: an exemplary One Health initiative. Journal of Medical Microbiology 69 (8), pp.1037-1039. (10.1099/jmm.0.001228)
- Jenkins, R. , Roberts, A. and Brown, H. L. 2015. On the antibacterial effects of manuka honey: mechanistic insights. Research and Reports in Biology 6 , pp.215-224. (10.2147/RRB.S75754)
- Reuter, M. et al., 2015. A PAS domain-containing regulator controls flagella-flagella interactions in Campylobacter jejuni. Frontiers in Microbiology 6 770. (10.3389/fmicb.2015.00770)
- Brown, H. L. et al. 2015. Campylobacter jejuni biofilms contain extracellular DNA and are sensitive to DNase I treatment. Frontiers in Microbiology 6 699. (10.3389/fmicb.2015.00699)
- Gerlach, R. G. et al., 2015. Prevention of biofilm formation and removal of existing biofilms by extracellular DNases of Campylobacter jejuni. PLoS ONE 10 (3) e0121680. (10.1371/journal.pone.0121680)
- Brown, H. L. et al. 2014. Chicken juice enhances surface attachment and biofilm formation of Campylobacter jejuni. Applied and Environmental Microbiology 80 (22), pp.7053-7060. (10.1128/AEM.02614-14)
- Marlow, V. L. et al., 2013. Blast a biofilm: a hands-on activity for school children and members of the public. Journal of Microbiology and Biology Education 14 (2), pp.152-254. (10.1128/jmbe.v14i2.563)
- Brown, H. L. et al. 2013. Tetrazolium reduction allows assessment of biofilm formation byCampylobacter jejuniin a food matrix model. Journal of Applied Microbiology 115 (5), pp.1212-1221. (10.1111/jam.12316)
Book sections
- Brown, H. L. 2022. Microbial growth. In: Rezaei, N. ed. Encyclopedia of Infection and Immunity. Vol. 1, Elsevier. , pp.324-335. (10.1016/B978-0-12-818731-9.00190-7)
Ymchwil
Trosolwg o Ymchwil
Rwy'n ymchwilio i sut mae cymunedau microbaidd yn rhyngweithio â meinweoedd lletyol a'i gilydd i yrru haint, dyfalbarhad ac iachâd. Mae fy ymchwil yn cwmpasu bioleg bioffilm, microbioleg clwyfau cronig, microbiomau tiwmor, a signalau gwesteiwr-microb, i ddatblygu strategaethau therapiwtig a diagnostig newydd ar gyfer cyflyrau anodd eu trin.
Mae gen i ddiddordeb arbennig mewn sut mae bacteria commensal ac opportunistic yn addasu i amgylcheddau cymhleth fel clwyfau a thiwmorau, a sut y gallwn harneisio ecoleg microbaidd i wella canlyniadau iechyd.
Themâu Ymchwil Cyfoes
Rhyngweithiadau Bacterial-Host
- Ymchwilio i sut mae secretomau ffibroblast yn dylanwadu ar firwsedd bacteriol a ffurfio bioffilm
- Archwilio sut mae cymunedau bacteriol rhywogaethau cymysg yn ymateb i signalau a ffactorau imiwnedd sy'n deillio o'r gwesteiwr
- Astudio rhyngweithiadau gwesteiwr-microbiom mewn canser y prostad, gan ganolbwyntio ar lid, modiwleiddio imiwnedd, a dyfalbarhad microbaidd
Rhyngweithiadau Bacterial-Bacteriol
- Deall sut mae deinameg pathogen commensal-yn gyrru dyfalbarhad microbaidd a haint opportunistaidd
- Defnyddio microbiota commensal i atal neu drechu pathogenau mewn amgylcheddau clwyfau cronig
- Archwilio synergedd a chystadleuaeth bioffilm mewn lleoliadau tiwmor a chlwyfau
Therapïau a Diagnosteg Arloesol
- Datblygu strategaethau gwrthficrobaidd a gwrthbioffilm sy'n trosoli moleciwlau sy'n deillio o westeion
- Ymchwilio i fesiglau allgellog bacteriol (bEVs) fel biofarcwyr anfewnwthiol a modulators cymunedol bioffilm
- Nodweddu secretome a signalau cyfryngol fesigl C . acnes mewn dilyniant tiwmor y prostad
- Targedu bioffilmiau Campylobacter jejuni gan ddefnyddio dulliau sy'n seiliedig ar DNase i darfu ar DNA allgellog a lleihau dyfalbarhad pathogen
- Astudio mecanweithiau goroesi ac ymwrthedd C. jejuni mewn amgylcheddau cadwyn fwyd o dan amodau aerobig a microaerobig
Addysgu
Rwy'n dysgu ar y modiwlau canlynol:
Sgiliau BI1001 ar gyfer Gwyddoniaeth
Organebau BI1003 a'r Amgylchedd
Cysyniadau BI2332 o Glefyd
BI3155 Bioleg heintiau ac Epidemioleg
Rwyf hefyd ar gael i oruchwylio myfyrwyr BSc, MSc ac MRes
Bywgraffiad
2022: Darlithydd mewn Microbioleg, Ysgol y Biowyddorau, Prifysgol Caerdydd
2019 - 2022: Ymchwilydd Ôl-ddoethurol, Ysgol Deintyddiaeth, Prifysgol Caerdydd
2018 - 2019: Ymchwilydd Ôl-ddoethurol, Ysgol Meddygaeth Milfeddygol, Prifysgol Surrey
2016 - 2018: Ymchwilydd Ôl-ddoethurol, Ysgol Deintyddiaeth, Prifysgol Caerdydd
2015 - 2016: Ymchwil Ôl-ddoethurol, Ysgol Gwyddorau Chwaraeon ac Iechyd Caerdydd, Prifysgol Metropolitan Caerdydd
2011 - 2015: Myfyriwr PhD, Institue of Food Research/University of East Anglia
2004 - 2011: Swyddog Arbrofol, Is-adran Bioddiogelwch, Labordai Covance Cyf
Anrhydeddau a dyfarniadau
2013: Gwobr Allgymorth Cymdeithas Microbioleg Gyffredinol
2013: Gwobr Newydd-ddyfodiad Allgymorth Prifysgol East Anglia (CUE EAST)
Aelodaethau proffesiynol
2025 ymlaen - aelod o Gymdeithas y DU ar gyfer Vessicles Allgellog
2022 ymlaen - aelod o Applied Microbiology International
2012 ymlaen - aelod o'r Gymdeithas Microbioleg
Pwyllgorau ac adolygu
2025 ymlaen: Golygydd Microbiology Outlooks
2020 - 2024: Golygydd Access Microbiology
Contact Details
+44 29225 14560
Adeilad Syr Martin Evans, Ystafell W2/03, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
Themâu ymchwil
Arbenigeddau
- Gofal iechyd oed
- Bacterioleg feddygol
- Microbioleg meddygol
- Zoonosis
- Un iechyd