Ewch i’r prif gynnwys
Monica Busse-Morris

Yr Athro Monica Busse-Morris


Yr Ysgol Meddygaeth

Ar gael fel goruchwyliwr ôl-raddedig


I have a specific interest in the development of exercise therapeutics in neurodegenerative conditions and extensive knowledge of the development and evaluation of complex interventions applied to neurodegeneration. I am interested more widely in the assessment and management of mobility problems and falls, methodologies for appropriate assessment of outcomes in complex health conditions and promotion of physical activity for health (along with behaviour change applications). I am currently developing and validating novel functional assessment methods and technologies to support patient monitoring to good clinical practice standards for application in ‘first-in-man’ clinical trials of ES derived stem cells in HD.  I am a reviewer for a range of international peer reviewed journals in the field. I am also a member of the Scientific and Bioethics Advisory Committee (SBAC) of the European Huntington's Disease Network (EHDN) and the EHDN Physiotherapy working group. My ORCID-ID is 0000-0002-5331-5909.























Adrannau llyfrau





My research has mainly focused on developing evidence and guidelines for targeted physical interventions in Huntington's disease (HD) and Parkinson's disease (PD). Such interventions are complex, and involve many components. It is therefore essential that the main "active components" within the intervention are defined and benefits evaluated in terms of relevant outcomes. We have adopted the Medical Research Council (MRC) Framework for design and evaluating complex interventions to provide a structure that should ultimately lead to full scale, robust controlled clinical trials.

Working closely with people with HD and their families as part of the research process is very important to us. We established the Wales HD Involving People Group in 2010 (now BRAIN Involve) with a view to ensuring that our work is always relevant and applicable to the needs of the HD community.  We have successfully conducted and published data from the first randomised and controlled multi-centre studies investigating different physiotherapy and exercise interventions for HD (MOVE TO EXERCISE, TRAIN-HD and COMMET-HD). This work has led to further funding for exercise intervention trials related in HD (ENGAGE-HD and ExERT-HD). The growing recognition of the importance of physical activity and mobility in HD is further evidenced by the FP-7 funded programme of work being conducted in REPAIR-HD (http://www.repair-hd.eu/) where I am a principle investigator along with a consortia of researchers based in Germany, France and Italy. I am also a principle investigator in the Wales BRAIN Unit where I lead the patient monitoring and patient and public involvement work-packages.

Research grants


  • Jacques and Gloria Gossweiler Foundation Research Grants in the field of Neurology "Physical Activity and Exercise Outcomes in Huntington's Disease." £411 00.00.
  • Huntington's Disease Association of England and Wales. "Promotion of  physical activity in Huntington's Disease clinics." £10 300.00.


  • MRC Confidence in Concept "Using wearable technology to predict perioperative high-risk patient outcomes." £39,490.

  • MRC Confidence in Concept  "Developing clinical applications for a novel multi-task functional assessment." £49,902.00.

  • Wellcome Trust ISSF Cross disciplinary awards  “Pilot study of motor coordination disorder in 22q11.2 deletion syndrome.“ £8,935.

  • Wellcome Trust ISSF Cross disciplinary awards “Automated assessment of timing and movement signatures in Huntington’s Disease.” £47,945

  • Wellcome Trust ISSF ISSF populations pilot awards “Feasibility of using consumer-targeted activity monitors in collecting physical activity data within the HealthWise Wales cohort: a pragmatic pilot study.” £28,414
  • Jacques and Gloria Gossweiler Foundation Research Grants in the field of Neurology “Exploring cognitive training as a non-pharmaceutical intervention for people with Huntingtons disease.” £94,071


  • Division of Health and Care Research Wales (DHCRW); Brain Repair And Intracranial Neurotherapeutics- Wales BRAIN Unit. £1.2m; lead applicant Professor W. Grey.


  • FP7-HEALTH-2013-INNOVATION-1 "REPAIR-HD Human pluripotent stem cell differentiation, safety and preparation for therapeutic transplantation in Huntington's disease". £1,705,800
  • Jacques and Gloria Gossweiler Foundation "ExeRT-HD Exercise Rehabilitation Trial in Huntington's Disease". £172,805
  • National Institute of Social Care and Health Research/ National Institute of Health Research "Move to Exercise: Home based exercise for people with Huntington's Disease". £687,362


  • Linden. Morris, Subramanian, Busse Wellcome Trust ISSF Seedcorn "Real Time fMRI neurofeedback as a treatment for Parkinson's Disease". £45,000


  • Neil Glendinning Research Grant Huntington's Disease Association: Task Training in Huntington's Disease £99,230
  • European Huntington's Disease Network. Feasibility and benefit of inspiratory muscle training in people with Huntington's disease. (co-applicant; £38,384)


  • National Institute for Social Care and Health Research Health Research Funding Scheme: Can community supported exercise benefit subjective wellbeing, physical activity levels and abilities in people with Huntington's disease? A randomised feasibility study and process evaluation (COMMET-HD) £122,720
  • Medical Research Council. National Prevention Research Initiative. Health Eating and Lifestyle in Pregnancy Study (HELP) (collaboration with South East Wales Trials Unit) (co-applicant; £1,041,422)


  • European Huntington's Disease Network. Reliability and minimal detectable change of measures of participation, functional activities and impairments in individuals with Huntington's disease ( £36,000)
  • Physiotherapy Research Foundation Scheme B. Respiratory Function in people with Huntington's disease: a cross sectional study (co-applicant; £6,500)
  • Research Capacity Building Consortium Wales PhD studentship. Respiratory Function in people with Huntington's disease: a cross sectional study (co-applicant; £51,558)


  • Chief Medical Officer for Wales Research Budget. Development and evaluation of a DVD resource for people with a neurodegenerative disease who may be at risk of falls.   £9,938.
  • Paul Jeffries Waters Bequest Fund to support research in Huntington' disease £2,820.


Physiotherapy Research Society. Mobility and Falls in Huntington's Disease. £500


I am in possession of a Post Graduate Certificate in Teaching and Learning in Higher Education, a Certificate in Teaching Statistics in Higher Education (Royal Statistical Society) and a Post Graduate Diploma in Clinical Trials (LSHTM). My research has a clear focus on physical activity and development and evaluation of complex interventions for people with Long Term Neurological Conditions (LTNCs). I collaborate closely with colleagues working in engineering and biosciences to achieve a translational focus to my work. I also have a particular interest in innovative methods for teaching research and statistics and the use of reliability analyses and mixed methods in healthcare research that has developed as a direct result of application in my research area.



BSc Physiotherapy (University of Stellenbosch), December 1993

BSc (Med) Hons. Ergonomics (first class) (University of Cape Town), December 1996

MSc (Med) Biomedical Sciences (distinction) (University of Cape Town), December 2001

PhD (University of Wales College of Medicine), July 2005

Post Graduate Certificate in Teaching and Learning (Kingston University), July 2001

Diploma in Research Methods (University of Wales College of Medicine), May 2003

Certificate in Teaching Statistics in Higher Education (Royal Statistical Society), February 2005

I am in possession of both a Post Graduate Certificate in Teaching and Learning and a Certificate in Teaching Statistics in Higher Education (Royal Statistical Society). My teaching interests and professional development is aligned with my research work and has a clear focus on physiotherapy provision for people with Long Term Neurological Conditions (LTNCs). I also have a particular interest in innovative methods for teaching research and statistics and the use of reliability analyses and mixed methods in healthcare research which has developed as a direct result of application in my research area. I contribute to teaching on the Research Methods of Health and Social Care, Experimental Designs, Neuroscience and Neurorehabilitation modules. I also collaborate with clinicians and researchers based both in other schools within Cardiff University and other academic institutions in the United Kingdom and regularly review grants submitted for funding and manuscripts submitted for publication in the field of physiotherapy, neurology and rehabilitation.

Anrhydeddau a dyfarniadau

Fellow of Learned Society of Wales April 2021

Aelodaethau proffesiynol

Registered Physiotherapist Health Professions Council PH 53577 January 1998

Member of Chartered Society of Physiotherapy January 1998

Fellow of Higher Education Institute July 2001

Safleoedd academaidd blaenorol

2022 ongoing Director Health and Care Research Wales Faculty.

2016 to 2022 Director Mind Brain Neuroscience Trials, Centre for Trials Research, Cardiff University, UK.

2015 to 2016 Deputy Head of School of Healthcare Sciences: Research and Innovation, Cardiff University UK

2014 to 2016 Professor of Healthcare Sciences, Associate Director South East Wales Trials Unit

2010 to 2014 Senior Lecturer: School of Healthcare Sciences, Cardiff University, UK

2005 to 2010 Lecturer: School of Healthcare Studies, Cardiff University, UK

Pwyllgorau ac adolygu

Future Leaders Fellows Development Networks’ Mentor 2021/22 cycle

Member of the STEMM1 (Medicine and Medical Sciences) Learned Society Scrutiny committee

Member of Cardiff University peer review college RWIF Innovation for All Funding Programme

Invited member DHSC/UKRI COVID-19 rapid response rolling call – College of Experts

Invited member of Wellcome Trust Translation-of Concept (ToC) funding panel

Member MRC Clinical Fellowships Panel

Member of NIHR HTA Commissioning Funding panel

Advisory board for Health and Care Economics Cymru

I regularly review manuscripts submitted for publication in Journal of Neurology, Neurosurgery and Psychiatry, European Journal of Neurology, Journal of Huntington’s Disease, Trials, Clinical Science, Journal of Physical Activity and Health, Physiotherapy, Physical Therapy, Neuromuscular Disorders, Clinical Biomechanics, Movement Disorders, Clinical Genetics and Journal of Geriatric Physical Therapy. I am a grant reviewer for Health and Care Research Wales (RfPPB) and National Institute for Health Research (NIHR) RfPB, HSDR and NIHR Post-Doctoral Fellowship programme and Advanced Fellowship programme, The Multiple Sclerosis Society, Parkinson’s Disease-UK, Huntington Disease Association, BIG Lottery fund, Canadian Frailty Network, Stroke Association, Medical Research Council, National Institute of Health Research, Wellcome Trust, Multiple Sclerosis Society, CSO Scotland and the Clinical Research, Global Brain Health Institute and Academic Committee of the ABN Clinical Training Fellowships. I have reviewed final reports submitted to NIHR funding panels.

Meysydd goruchwyliaeth

I am interested in supervising projects in:

  • Clinical Evaluation of Physical Activity and Sleep in neurodegenerative disease
  • Complex interventions and self-management support
  • Digital health interventions applied to long term conditions
  • Mixed methods applied health research

Current supervision.

  1. Eleni Glarou. PhD; School of Medicine. Understanding multi-party communication in therapy sessions for children with Autism Spectrum Disorder (ASD) and Sensory Processing (SP) difficulties - the value of interaction analysis (start 1 October 2018).
  2. Andreas Markoulidakis. PhD, School of Medicine (start 1 October 2019). Identification and modelling of causal genetic and environmental factors for HD severity and progression.

Previous PGR projects.

  1. Movement Deficits and Physiotherapy Huntington’s disease. Awarded 2013. Hanan Khalil
  2. A comparative analysis of physiotherapy services in different health environments. Awarded 2014. Abdulrahman Altowaijri.
  3. Respiratory Function in people with Huntington’s disease: a cross sectional study. Awarded 2014. Una Jones
  4. Training the Brain in Huntington's Disease. Awarded 2017
  5. An exploration of Exercise Experiences in People with Huntington’s disease: Who makes the time? Awarded 2019. Katy Hamana
  6. Exploring clinical applications for a novel multi-task functional assessment: matching appropriate technology to clinical need. Awarded 2021. Samuel Woodgate.
  7. Bethan Mair Edwards. 2A Window of Opportunity”: Describing and Developing an Evidence, Theory, and Practice-Informed Occupational Therapy Intervention for People Living with Early-Stage Dementia. Awarded 2022.


Fel hyfforddwr gweithredol a mentor ymroddedig ymchwilwyr iechyd cymhwysol cynnar a chanol-gyrfa, rwy'n ymgysylltu'n fras ym maes datblygu ymchwilwyr proffesiynol perthynol i iechyd. Rwyf wedi bod yn fentor yn Mentor Rhwydweithiau Datblygu Cymrodyr Arweinwyr y Dyfodol 2021/22 a 2022/23 ac rwyf wedi datblygu a chyflwyno hyfforddiant mentora i ymchwilwyr sy'n gweithio mewn lleoliadau ymchwil iechyd a gofal cymdeithasol cymhwysol. Rwy'n Ymarferydd Mewnwelediad achrededig ac yn defnyddio hyn mewn amrywiaeth o fentrau datblygu ymchwilwyr sy'n benodol i ymchwil iechyd a gofal cymdeithasol cymhwysol. Yn rhinwedd fy swydd fel Cyfarwyddwr Cyfadran Ymchwil Iechyd a Gofal Cymru, rwy'n arwain yr ymateb strategol i'r Adolygiad o Yrfaoedd Ymchwil yng Nghymru a gomisiynwyd ar y cyd gan Ymchwil Iechyd a Gofal Cymru, Gofal Cymdeithasol Cymru ac Addysg a Gwella Iechyd Cymru. Rwy'n aelod o weithgor Egwyddorion a Rhwymedigaethau Monitro Anghydraddoldebau Rhyw Fforwm Hyfforddiant Academaidd Clinigol a'r Cyngor Ymchwil Proffesiynau Iechyd Cysylltiedig.

Rwy'n gyn-aelod etholedig o Bwyllgor Gweithredol Clefyd Huntington Ewrop, rhwydwaith annibynnol dielw sy'n ymroddedig i hyrwyddo ymchwil, cynnal treialon clinigol a gwella gofal i bobl y mae Clefyd Huntington yn effeithio arnynt. Rwyf wedi cadeirio sesiynau llawn yn ystod y tri chyfarfod llawn Ewropeaidd diwethaf, wedi bod yn aelod o Bwyllgor Adolygu Gwyddonol a HD, y Grŵp Cynghori Bio Gwyddonol a Moeseg a chyd-hwylusydd arweiniol gweithgor ffisiotherapi Rhwydwaith Clefyd Huntington Ewrop (EHDN) lle bûm yn weithgar wrth drefnu cyfarfodydd grŵp rhyngwladol am fwy na 6 blynedd gan arwain at gydweithio sefydledig ledled y Deyrnas Unedig. Ewrop, Awstralia ac UDA. Mae'r cydweithrediadau hyn wedi arwain at gyhoeddi'r canllawiau clinigol cyntaf erioed ar sail tystiolaeth ar gyfer rheoli ffisiotherapi ar gyfer Huntington's. Cyhoeddwyd y canllawiau hyn a gydnabyddir yn rhyngwladol yn Journal for Neurology yn 2020. Fel cynrychiolydd clinig Clefyd Huntington Caerdydd ac Arweinydd Clinigol ar gyfer Ffisiotherapi, rwyf wedi siarad yn lleol ac yn rhyngwladol ar ddiwrnodau teuluol i bobl ag HD lle gall darparu gwybodaeth a datblygiad ymwybyddiaeth effeithio'n uniongyrchol ar allu unigolyn i ymdopi â'r cyflwr niwrolegol hirdymor penodol hwn. Trefnais Glinig Rheoli Ymchwil Clefydau hynod lwyddiannus Cardiff Huntington am 6 blynedd yn olynol ac rwy'n parhau i fod yn gyfrannwr gweithredol i'r digwyddiad. Rwyf wedi bod yn allweddol wrth sefydlu Grŵp Cynnwys Pobl Clefyd Huntington Cymru. Mae'r grŵp hwn bellach yn ymuno ag uned BRAIN Cymru, BRAIN Involve.