![Monica Busse-Morris](https://profiles-cardiff.imgix.net/attachments/238?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Professor Monica Busse-Morris
Teams and roles for Monica Busse-Morris
Honorary Professor Centre for Trials Research
Honorary Professor
Overview
I am a registered physiotherapist and trials methodologist based in the Centre for Trials Research, Cardiff University where we form partnerships with researchers and build lasting relationships with the public to tackle the big diseases and health concerns of our time. We aim to prevent ill-health, protect and prolong life by designing, developing and testing interventions to improve health and wellbeing and importantly work to understand the biological, environmental and social causes of disease and ill-health. I am also Director of the Health and Care Research Wales Faculty (https://healthandcareresearchwales.org/faculty), the core pillar of the All Wales national research career pathway, established in 2022.
I completed my undergraduate studies in Physiotherapy in South Africa and went on to complete further post-graduate qualifications in Ergonomics and Biomechanics. I have a longstanding interest in applied health research methods and hold a Diploma in Clinical Trials from London School of Hygiene and Tropical Medicine. I serve on the Medical Research Council Clinical Fellowships Panel, the NIHR Advanced Fellowship Panel NIHR Health Technology Assessment Funding Panel. I am a fellow of the Higher Education Academy, an elected fellow of the Learned Society of Wales, the National Academy for Arts and Sciences in Wales and a Level 7 qualified executive coach and accredited Insights Practitioner.
During my PhD studies, I used 3D motion capture, surface EMG and wearable activity trackers to explore muscle weakness and function in a range of neurological disorders and throughout my research career have continued to progress these methods in a range of multi-centre observational, mechanistic and interventional studies and in laboratory and community settings. I am particularly interested in the development and evaluation of complex non-pharmacological interventions for people living with long term complex health conditions and exploring the interplay between modifiable and non-modifiable factors associated with disease progression. I have led a programme of research exploring mobility, physical and cognitive training and life-style approaches in Huntington’s Disease, many of which informed the publication, in 2020, of the first evidenced based international physiotherapy clinical guidelines for Huntington’s Disease.
I mentor early career clinicians and researchers in varied health and social care settings and lead a range of clinical studies and trials with national and international research teams, for example the DOMINO-HD consortium funded through the JPND Multinational research projects on Health and Social Care for Neurodegenerative Diseases, the NIHR funded LISTEN trial which is evaluating a co-designed self-management support intervention for long Covid and the NIHR funded TIPTOE trial which is focussing on older people with osteoarthritis and multi-morbidities. I have a longstanding commitment to public and patient involvement and codesign in research and established BRAIN Involve, the public involvement arm of the Wales Brain unit. I have active collaborations with researchers and clinicians working across a variety of health service settings (for example orthopaedics, critical care and autism spectrum disorder). My H-index (Scopus) is 28 and my life-time grant income is in the region of £28 000 000.00.
Publication
2025
- Busse-Morris, M. et al. 2025. Effectiveness of a personalised self-management intervention for people living with long covid (Listen trial): pragmatic, multicentre, parallel group, randomised controlled trial. BMJ Medicine 4 (1) e001068. (10.1136/bmjmed-2024-001068)
- Dalléry, R. et al., 2025. The joint memory effect: challenging the selfish stigma in Huntington’s disease?. Brain Communications 7 (1) fcae440. (10.1093/braincomms/fcae440)
- Edwards, B. M. et al., 2025. Real-world occupational therapy interventions for early-stage dementia: Characteristics and contextual barriers. Dementia 24 (3), pp.388-407. (10.1177/14713012241272815)
- Fahed, V. S. et al., 2025. Comparison of acoustic voice features derived from mobile devices and studio microphone recordings. Journal of Voice 39 (2), pp.559.e1-559.e18. (10.1016/j.jvoice.2022.10.006)
- Glarou, E. et al. 2025. Building rapport in occupational therapy with autistic children: A discourse analytical study. SSM - Qualitative Research in Health 8 100611. (10.1016/j.ssmqr.2025.100611)
- Harris, S. R. S. et al., 2025. Cost‐effectiveness of a personalised self‐management intervention for people living with long Covid: the LISTEN randomised controlled trial. Health Expectations 28 e70357. (10.1111/hex.70357)
- Ioakeimidis, V. et al. 2025. In vivo mapping of striatal microstructure in Huntington's disease with Soma and Neurite Density Imaging. [Online].MedRxiv: MedRxiv. Available at: https://www.medrxiv.org/content/10.1101/2025.03.17.25324107v1.
- Ioakeimidis, V. et al. 2025. In vivo mapping of striatal neurodegeneration in Huntington's disease with Soma and Neurite Density Imaging. eLife 14 RP107661. (10.7554/eLife.107661.1)
- Jones, F. et al., 2025. We must recognise the collective wisdom of those with lived experience of long covid (Opinion). BMJ 388 r243. (10.1136/bmj.r243)
- Khalil, H. et al., 2025. Delivering trauma-focused physiotherapy interventions for trauma-exposed refugees: a qualitative study exploring perspectives and experiences from Jordan and Kenya. Physiotherapy Theory and Practice: An International Journal of Physical Therapy 41 (9), pp.1886-1900. (10.1080/09593985.2025.2484609)
- Leggat, F. et al., 2025. Personalisation at the core of success: Process evaluation of the LISTEN randomised controlled trial evaluating a personalised self-management support intervention for people living with Long Covid.. Health Expectations 28 (3) e70270. (10.1111/hex.70270)
- Williams, N. et al. 2025. Effectiveness of a community-based rehabilitation programme following hip fracture: results from the Fracture in the Elderly Multidisciplinary Rehabilitation - phase III (FEMuR III) randomised. BMJ Open 15 e091603. (10.1136/bmjopen-2024-091603)
2024
- Deere, R. et al. 2024. Multi-domain self-management in older people with osteoarthritis and multimorbidities: protocol for the TIPTOE randomised controlled trial. Trials 25 557. (10.1186/s13063-024-08380-7)
- Doheny, E. P. et al., 2024. Assessment of Fitbit Charge 4 for sleep stage and heart rate monitoring against polysomnography and during home monitoring in Huntington's disease. Journal of Clinical Sleep Medicine 20 (7), pp.1163-1171. (10.5664/jcsm.11098)
- Edwards, B. M. et al. 2024. Exploring the impact of early-stage dementia on everyday activities. British Journal of Occupational Therapy 87 (11), pp.704-714. (10.1177/03080226241261178)
- Fahed, V. S. et al., 2024. Language-independent acoustic biomarkers for quantifying speech impairment in Huntington's Disease. American Journal of Speech-Language Pathology 33 (3), pp.1390-1405. (10.1044/2024_AJSLP-23-00175)
- Ioakeimidis, V. et al. 2024. Protocol for a randomised controlled unblinded feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease. BMJ Open 14 (7) e082161. (10.1136/bmjopen-2023-082161)
- Jones, F. et al., 2024. Using co‐design methods to develop new personalised support for people living with Long Covid: The ‘LISTEN’ intervention. Health Expectations 27 (3) e14093. (10.1111/hex.14093)
- Jones, U. , Hamana, K. and Busse, M. 2024. Promoting physical activity in Huntington's Disease: co-design of a care partner resource. Journal of Huntington's Disease 13 (3), pp.375-383. (10.3233/JHD-240014)
- Randell, E. et al. 2024. Exploring critical intervention features and trial processes in the evaluation of sensory integration therapy for autistic children. BMC Trials 25 (1) 131. (10.1186/s13063-024-07957-6)
2023
- Fakolade, A. et al., 2023. Mapping two decades of multiple sclerosis rehabilitation trials: A systematic scoping review and call to action to advance the study of race and ethnicity in rehabilitation research. Multiple Sclerosis and Related Disorders 72 104606. (10.1016/j.msard.2023.104606)
- Ioakeimidis, V. et al. 2023. Protocol for a randomised controlled feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington's disease. [Online].medRxiv: medRxiv. (10.1101/2023.11.15.23298581)Available at: https://doi.org/10.1101/2023.11.15.23298581.
- Lemoine, L. et al., 2023. The striatum in time production: the model of Huntingtons's disease in longitudinal study. Neuropsychologia 179 108459. (10.1016/j.neuropsychologia.2022.108459)
- Markoulidakis, A. et al. 2023. A tutorial comparing different covariate balancing methods with an application evaluating the causal effects of substance use treatment programs for adolescents. Health Services and Outcomes Research Methodology 23 , pp.115-148. (10.1007/s10742-022-00280-0)
- Metzler-Baddeley, C. et al. 2023. Applying an integrated knowledge translation framework approach to develop a tablet-based rhythmic movement training intervention for people with Huntington’s disease. [Online].JMIR Preprints. (10.2196/preprints.48395)Available at: https://preprints.jmir.org/preprint/48395.
- Metzler-Baddeley, C. et al. 2023. HD-DRUM, a tablet-based drumming training App intervention for people with Huntington Disease: App development study. Journal of Medical Internet Research 2023 (7) e48395. (10.2196/48395)
- Potter, C. et al. 2023. Effectiveness and cost-effectiveness of a personalised self-management intervention for living with long covid: protocol for the listen randomised controlled trial. Trials 24 75. (10.1186/s13063-023-07090-w)
2022
- Busse, M. et al. 2022. A web-based life-style, exercise and activity intervention for people with progressive multiple sclerosis results of a single-arm feasibility study. Multiple Sclerosis and Related Disorders 57 103388. (10.1016/j.msard.2021.103388)
- Desai, R. et al., 2022. Postural control and gait measures derived from wearable inertial measurement unit devices in Huntington's disease: recommendations for clinical outcomes. Clinical Biomechanics 96 105658. (10.1016/j.clinbiomech.2022.105658)
- Drew, C. J. and Busse, M. 2022. Considerations for clinical trial design and conduct in the evaluation of novel advanced therapeutics in neurodegenerative disease. In: Lane, E. , Cheney, D. and Lelos, M. eds. Current Challenges in Cell Therapy for Neurodegenerative Diseases. International Review of Neurobiology Elsevier. , pp.235-279. (10.1016/bs.irn.2022.09.006)
- Drew, C. J. et al. 2022. F21 Co-design of a lifestyle intervention to improve quality of life in Huntington's disease. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September 2022. Vol. 93.BMJ Publishing Group. (10.1136/jnnp-2022-ehdn.112)
- Fahed, V. S. et al., 2022. F52 Acoustic voice features in Huntington's disease in native English, Spanish and Polish speakers. Presented at: EHDN 2022 Plenary Meeting 16-18 September 2022. Vol. 93.BMJ Publishing Group. (10.1136/jnnp-2022-ehdn.143)
- Fritz, N. E. et al., 2022. An MDS evidence-based review on treatments for Huntington's disease [Letter]. Movement Disorders 37 (7), pp.1566-1567. (10.1002/mds.29059)
- Hare, E. et al. 2022. Cognitive processes of apathy in Huntington's Disease show high sensitivity to disease progression. Clinical Parkinsonism & Related Disorders 7 100168. (10.1016/j.prdoa.2022.100168)
- Heaton-Shrestha, C. et al., 2022. Co-designing personalised self-management support for people living with long Covid: the LISTEN protocol. PLoS ONE 17 (10) e0274469. (10.1371/journal.pone.0274469)
- Lozano-García, M. et al., 2022. F61 Validation of a gait event detection algorithm during overground walking in Huntington's disease. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September 2022. Vol. 93.BMJ Publishing Group. (10.1136/jnnp-2022-ehdn.152)
- Mann, E. et al., 2022. F62 Validation of digital assessment of physical activity in Huntington’s disease: comparing fitbit charge 4 step count with research-grade accelerometers. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September 2022. BMJ Publishing Group. , pp.A58-A59. (10.1136/jnnp-2022-ehdn.153)
- Markoulidakis, A. et al. 2022. Lifestyle index for individuals with HD (LifeHD): an aggregated measure that characterises the lifestyle habits of individuals with HD. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September. Vol. 93.Vol. S1. (10.1136/jnnp-2022-ehdn.111)
- Markoulidakis, A. et al. 2022. Covariate balancing & weighting web app (COBWEB): an online tool simplifying robust causal inference in observational studies. Journal of Neurology, Neurosurgery and Psychiatry 93 (S1) A44. (10.1136/jnnp-2022-ehdn.114)
- Metzler-Baddeley, C. et al. 2022. HD-DRUM – a novel computerised drumming training for movement and cognitive abilities in people with Huntington’s disease – app development and protocol of a randomised controlled feasibility study. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September 2022. Vol. 93.Vol. S1. , pp.A100-A101. (10.1136/jnnp-2022-ehdn.267)
- Milosevic, S. et al. 2022. Understanding the support experiences of families of children with autism and sensory processing difficulties: A qualitative study.. Health Expectations 25 (3), pp.1118-1130. (10.1111/hex.13465)
- Morgan-Jones, P. et al. 2022. Monitoring and managing lifestyle behaviours using wearable activity trackers: a mixed methods study of views from the Huntington's disease community. JMIR Formative Research 6 (6) e36870. (10.2196/36870)
- Quinn, L. et al. 2022. Physical activity and exercise outcomes in Huntington's disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington's disease. Parkinsonism & Related Disorders 101 , pp.75-89. (10.1016/j.parkreldis.2022.06.013)
- Randell, E. et al. 2022. Sensory integration therapy for children with autism and sensory processing difficulties: the SenITA RCT. Health Technology Assessment 26 (29)(10.3310/TQGE0020)
- Rosser, A. E. et al. 2022. Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder. Brain 145 (5), pp.1584-1597. (10.1093/brain/awac086)
2021
- Badin, R. A. et al., 2021. Stem cells for Huntington’s disease (SC4HD): an international consortium to facilitate stem cell-based therapy for Huntington’s disease. Journal of Huntington's Disease 10 (2), pp.221-226. (10.3233/JHD-210473)
- Busse, M. et al. 2021. A web-based physical activity intervention for people with progressive Multiple Sclerosis: application of consensus-based intervention development guidance. BMJ Open 11 (3) e045378. (10.1136/bmjopen-2020-045378)
- Chopard, D. et al., 2021. Text mining of adverse events in clinical trials: Deep learning approach. JMIR Medical Informatics 9 (12) e28632. (10.2196/28632)
- Desai, R. et al., 2021. Evaluation of gait initiation parameters using inertial sensors in Huntington's Disease: insights into anticipatory postural adjustments and cognitive interference. Gait and Posture 87 , pp.117-122. (10.1016/j.gaitpost.2021.04.021)
- Drew, C. et al. 2021. Protocol for an open label, phase I trial within a cohort of fetal cell transplants in people with Huntington’s disease. Brain Communications 3 (1) fcaa230. (10.1093/braincomms/fcaa230)
- Griffin, B. A. et al., 2021. Estimating the causal effects of modifiable, non-genetic factors on Huntington Disease progression using propensity score weighting. Parkinsonism and Related Disorders 83 , pp.56-62. (10.1016/j.parkreldis.2021.01.010)
- Hamana, K. et al. 2021. An exploration of physical activity experiences throughout the Huntington's disease journey: supporting development of theoretically underpinned complex interventions. Disability and Rehabilitation 43 (11), pp.1565-1575. (10.1080/09638288.2019.1671501)
- Jones, A. et al. 2021. Conducting focus groups in neurodegenerative disease populations: ethical and methodological considerations. BMJ Open 11 (1) e041869. (10.1136/bmjopen-2020-041869)
- Jones, L. et al., 2021. Can wearable technology be used to approximate cardiopulmonary exercise testing metrics?. Perioperative Medicine 10 9. (10.1186/s13741-021-00180-w)
- Jones, U. et al. 2021. The development of PAT‐HD: a co‐designed tool to promote physical activity in people with Huntington’s disease. Health Expectations 24 (2), pp.638-647. (10.1111/hex.13210)
- Karen, K. et al., 2021. Quantification of daily-living gait quantity and quality using a wrist-worn accelerometer in Huntington's Disease. Frontiers in Neurology 12 719442. (10.3389/fneur.2021.719442)
- Latchem-Hastings, J. et al. 2021. Lifestyle, exercise and activity package for people living with progressive multiple sclerosis (LEAP-MS): protocol for a single-arm feasibility study. Pilot and Feasibility Studies 7 111. (10.1186/s40814-021-00852-w)
- Lowe, R. et al. 2021. Lifestyle, exercise and activity package for people living with progressive Multiple Sclerosis (LEAP-MS): adaptions during the COVID-19 pandemic and remote delivery for improved efficiency. Trials 22 286. (10.1186/s13063-021-05245-1)
- Lunven, M. et al., 2021. Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT). PLoS ONE 16 (8) e0253064. (10.1371/journal.pone.0253064)
- Muratori, L. M. et al., 2021. Measures of postural control and mobility during dual-tasking as candidate markers of instability in Huntington's Disease. Human Movement Science 80 102881. (10.1016/j.humov.2021.102881)
- Simpson, S. et al. 2021. Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum. International Journal of Obesity 45 , pp.1728-1739. (10.1038/s41366-021-00835-0)
- Woodgate, S. et al. 2021. Objectively characterizing Huntington’s disease using a novel upper limb dexterity test. Journal of Neurology 268 , pp.2550-2559. (10.1007/s00415-020-10375-8)
2020
- Busse, M. and Ramdharry, G. 2020. Targeting sedentary behaviour in neurological disease. Practical Neurology 20 (3), pp.187-188. (10.1136/practneurol-2019-002491)
- Jones, U. and Busse, M. 2020. Navigating the challenges of COVID-19: staying active with HD [Abstract]. Neurotherapeutics 17 (S), pp.10-11. (10.1007/s13311-020-00945-z)
- Jones, U. , Hamana, K. and Busse, M. 2020. Acceptability of a co-designed tool to promote physical activity in people with Huntington's disease [Abstract]. Neurotherapeutics 17 (S) 11. (10.1007/s13311-020-00945-z)
- Markoulidakis, A. et al. 2020. A tutorial comparing different covariate balancing methods with an application evaluating the causal effect of exercise on the progression of Huntington’s disease. [Online].arXiv. Available at: https://arxiv.org/abs/2010.09563.
- Quinn, L. et al. 2020. Clinical recommendations to guide physical therapy practice for Huntington disease. Neurology 94 (5), pp.217-228. (10.1212/WNL.0000000000008887)
- Steventon, J. et al. 2020. Altered cerebrovascular response to acute exercise in patients with Huntington’s Disease. Brain Communications 2 (1) fcaa044. (10.1093/braincomms/fcaa044)
- Williams, N. et al., 2020. Protocol for a definitive randomised controlled trial and economic evaluation of a community-based rehabilitation programme following hip fracture: fracture in the elderly multidisciplinary rehabilitation—phase III (FEMuR III). BMJ Open 10 e039791. (10.1136/bmjopen-2020-039791)
- Yhnell, E. et al. 2020. A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD). Pilot and Feasibility Studies 6 88. (10.1186/s40814-020-00623-z)
2019
- Bachoud-Levi, A. et al., 2019. International guidelines for the treatment of Huntington's Disease. Frontiers in Neurology 10 710. (10.3389/fneur.2019.00710)
- Clare, L. et al., 2019. Cognitive rehabilitation, self-management, psychotherapeutic and caregiver support interventions in progressive neurodegenerative conditions: A scoping review. NeuroRehabilitation 43 (4), pp.443-471. (10.3233/NRE-172353)
- Drew, C. J. G. et al. 2019. Physical activity and exercise outcomes in Huntington Disease (PACE-HD): Protocol for a 12-Month trial within cohort evaluation of a physical activity intervention in people with Huntington Disease. Physical Therapy 99 (9), pp.1201-1210. (10.1093/ptj/pzz075)
- Jones, U. et al. 2019. Exploration of a co-production approach to developing a walking group with people with Huntington's Disease. Med One 4 e190022. (10.20900/mo.20190022)
- Playle, R. et al. 2019. Exercise interventions in Huntington's disease: An individual patient data meta-analysis. Movement Disorders Clinical Practice 6 (7), pp.567-575. (10.1002/mdc3.12809)
- Randell, E. et al. 2019. Sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children: study protocol for a pragmatic randomised controlled trial.. Trials 20 113. (10.1186/s13063-019-3205-y)
- Watt, F. E. et al., 2019. Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury. Osteoarthritis and Cartilage 27 (1), pp.23-33. (10.1016/j.joca.2018.08.001)
2018
- Bennasar, M. et al., 2018. Automated assessment of movement impairment in Huntington's disease. IEEE Transactions on Neural Systems and Rehabilitation Engineering 26 (10), pp.2062-2069. (10.1109/TNSRE.2018.2868170)
- Busse, M. et al. 2018. J09 A new trial design for evaluating exercise outcomes in Huntington's Disease. Journal of Neurology, Neurosurgery and Psychiatry 89 (Supp 1), pp.A100 - A101. (10.1136/jnnp-2018-EHDN.269)
- Button, K. et al. 2018. An evaluation of TRAK physiotherapy self management intervention development and delivery for knee conditions. Presented at: OARSI 2018 World Congress on Osteoarthritis Liverpool 26-29 April 2018. , pp.-.
- Button, K. et al. 2018. Integrating self-management support for knee injuries into routine clinical practice: TRAK intervention design and delivery. Musculoskeletal Science and Practice 33 , pp.53-60. (10.1016/j.msksp.2017.11.002)
- Jones, U. , Hamana, K. and Busse-Morris, M. 2018. Working together to promote physical activity in people with huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry 89 (S1), pp.A81. H41. (10.1136/jnnp-2018-EHDN.219)
- Mestre, T. et al., 2018. Quality of life measures in Huntington’s Disease: critique and recommendations for measures assessing patient health‐related quality of life and caregiver quality of life. Movement Disorders 33 (5), pp.742-749. (10.1002/mds.27317)
- Polgar, S. et al., 2018. Assessing the efficacy of cell transplantation for Parkinson's Disease: a patient-centered approach. Journal of Parkinson's Disease 8 (3), pp.375-383. (10.3233/JPD-181309)
- Yhnell, E. et al. 2018. Exploring computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD): protocol for a randomised feasibility study. Pilot and Feasibility Studies 4 45. (10.1186/s40814-018-0237-0)
2017
- Busse, M. et al. 2017. Physical activity self-management and coaching compared to social interaction in Huntington’s disease: Results from the ENGAGE-HD randomized, controlled, pilot feasibility trial. Physical Therapy 97 (6), pp.625-639. (10.1093/ptj/pzx031)
- Clinch, S. et al. 2017. Rehabilitation training in neural restitution. In: Dunnett, S. B. and Bjorklund, A. eds. Progress in Brain Research. Vol. 230, Elsevier. , pp.305-329. (10.1016/bs.pbr.2016.12.006)
- Fritz, N. et al., 2017. A classification system to guide physical therapy management in Huntington’s disease: a case series. Journal of Neurologic Physical Therapy 41 (3), pp.156-163. (10.1097/NPT.0000000000000188)
- Fritz, N. et al., 2017. Physical therapy and exercise interventions in Huntington's disease: a mixed methods systematic review. Journal of Huntington's Disease 6 (3), pp.217-235. (10.3233/JHD-170260)
- Khalil, H. , Busse-Morris, M. and Quinn, L. 2017. A pilot study of a minimally supervised home exercise and walking program for people with Parkinson’s disease in Jordan. Neurodegenerative Disease Management 7 (1)(10.2217/nmt-2016-0041)
- Quinn, L. and Busse, M. 2017. The role of rehabilitation therapy in Huntington disease. In: Feigen, A. S. and Anderson, K. E. eds. Handbook of Clinical Neurology: Huntington Disease. Vol. 144, Elsevier: Monograph Series. , pp.151-165. (10.1016/B978-0-12-801893-4.00013-4)
- Quinn, L. et al. 2017. Physical therapy and exercise interventions in Huntington's disease: a mixed methods systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports 15 (7), pp.1783-4433. (10.11124/JBISRIR-2016-003274)
2016
- Bennasar, M. et al. 2016. Huntington's Disease assessment using tri axis accelerometers. Procedia Computer Science 96 , pp.1193-1201. (10.1016/j.procs.2016.08.163)
- Drew, C. et al. 2016. Integrating technology into complex intervention trial processes: a case study. Trials 17 (1) 551. (10.1186/s13063-016-1674-9)
- Jones, C. et al., 2016. The societal cost of Huntington’s disease: are we underestimating the burden?. European Journal of Neurology 23 (10), pp.1588-1590. (10.1111/ene.13107)
- Jones, U. F. et al. 2016. Respiratory decline is integral to disease progression in Huntington's disease [Letter]. European Respiratory Journal 48 (2), pp.585-588. (10.1183/13993003.02215-2015)
- Mestre, T. A. et al., 2016. Rating scales for behavioural symptoms in Huntington's Disease: critique and recommendations. Movement Disorders 31 (10), pp.1466-1478. (10.1002/mds.26675)
- Quinn, L. et al. 2016. Development and delivery of a physical activity intervention for people with Huntington Disease. Journal of Neurologic Physical Therapy 40 (2), pp.71-80. (10.1097/NPT.0000000000000119)
- Townhill, J. et al. 2016. Using Actiwatch to monitor circadian rhythm disturbance in Huntington' disease: A cautionary note. Journal of Neuroscience Methods 265 , pp.13-18. (10.1016/j.jneumeth.2016.01.009)
2015
- Dawes, H. et al., 2015. Exercise testing and training in people with Huntington's diseas. Clinical Rehabilitation 29 (2), pp.196-206. (10.1177/0269215514540921)
2014
- Busse, M. et al. 2014. Supporting physical activity engagement in people with Huntington's disease (ENGAGE-HD): study protocol for a randomized controlled feasibility trial. Trials 15 (1) 487. (10.1186/1745-6215-15-487)
- Busse, M. et al. 2014. Optimising mobility outcome measures in Huntington's disease. Journal of Huntington's Disease 3 (2), pp.175-188. (10.3233/JHD-140091)
- Jones, K. et al. 2014. Physiotherapy task orientated approach: A case report. Journal of neurology, neurosurgery and psychiatry 85 (1) A68. (10.1136/jnnp-2014-309032.192)
- Jones, U. F. et al. 2014. Respiratory function decreases with progression of Huntington's Disease. Journal of Neurology, Neurosurgery & Psychiatry 85 (Suppl), pp.A61-A62. (10.1136/jnnp-2014-309032.173)
2013
- Busse, M. et al. 2013. A randomized feasibility study of a 12-week community-based exercise program for people with Huntington's Disease. Journal of Neurologic Physical Therapy 37 (4), pp.149-158. 1557-0576/13/3704-0149. (10.1097/NPT.0000000000000016)
- Dalton, A. et al., 2013. Analysis of gait and balance through a single triaxial accelerometer in presymptomatic and symptomatic Huntington's disease. Gait & Posture 37 (1), pp.49-64. (10.1016/j.gaitpost.2012.05.028)
- Harrison, D. J. et al. 2013. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Experimental Neurology 248 , pp.457-469. (10.1016/j.expneurol.2013.07.014)
- Khalil, H. et al. 2013. What effect does a structured home-based exercise programme have on people with Huntington's disease? A randomized, controlled pilot study. Clinical Rehabilitation 27 (7), pp.646-658. (10.1177/0269215512473762)
- Quinn, L. , Busse, M. and Dal Bello-Haas, V. 2013. Management of upper extremity dysfunction in people with Parkinson disease and Huntington disease: facilitating outcomes across the disease lifespan. Journal of Hand Therapy 26 (2), pp.148-155. (10.1016/j.jht.2012.11.001)
- Quinn, L. , Busse, M. and Rosser, A. E. 2013. Critical features in the development of exercise-based interventions for people with Huntington's disease. European Neurological Review 8 (1), pp.10-13.
- Quinn, L. et al. 2013. Reliability and minimal detectable change of physical performance measures in individuals with pre-manifest and manifest Huntington disease. Physical Therapy 93 (7), pp.942-956. (10.2522/ptj.20130032)
2012
- Busse, M. et al. 2012. Practice, progress and future directions for physical therapies in Huntington's Disease. Journal of Huntington's Disease 1 (2), pp.175-185. (10.3233/JHD-120025)
- Busse, M. et al. 2012. Q12 A randomised feasibility study of a 12-week exercise programme in Huntington's disease (HD) [Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 83 (S1), pp.A58-A59. (10.1136/jnnp-2012-303524.182)
- Griffiths, A. , Busse, M. and Sarin, B. 2012. Do the understanding, knowledge and fears of the caregivers of first time stroke survivors accurately reflect the difficulties faced after discharge from hospital?. Presented at: Welsh Stroke Conference 2012 Newport, Wales 22nd June 2012.
- Hamana, K. et al. 2012. Q13 Perspectives of participating in a 12-week exercise programme for people with early -mid stage Huntington's disease [Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 83 (S1), pp.A59. (10.1136/jnnp-2012-303524.183)
- Jones, K. et al. 2012. Q14 Sub maximal exercise testing in people with early stage Huntington's disease [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83 (S1), pp.A59. (10.1136/jnnp-2012-303524.184)
- Jones, K. et al. 2012. Sub maximal exercise testing in people with early stage Huntington’s Disease [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83 (S. 1) A59. (10.1136/jnnp-2012-303524.184)
- Jones, U. F. , Enright, S. and Busse, M. 2012. Management of respiratory problems in people with neurodegenerative conditions: a narrative review. Physiotherapy 98 (1), pp.1-12. (10.1016/j.physio.2011.03.002)
- Khalil, H. et al. 2012. Q15 A pilot study of an exercise intervention to improve motor function in people with Huntington's disease (HD) [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83 (S1), pp.A59. (10.1136/jnnp-2012-303524.185)
- Quinn, L. and Busse, M. 2012. Physiotherapy clinical guidelines for Huntington’s disease. Neurodegenerative Disease Management 2 (1), pp.21-31. (10.2217/nmt.11.86)
- Read, J. et al., 2012. I03 Evaluation of life time physical activity levels in Huntington's disease [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83 (S1), pp.A33. (10.1136/jnnp-2012-303524.102)
2011
- Jones, U. F. et al. 2011. A pilot study of influences on physical activity level and exercise capacity in people with Huntington's disease [Abstract]. Physiotherapy 97 (s1), pp.eS570. RR-PL-1276. (10.1016/j.physio.2011.04.002)
- Pickering, D. and Busse, M. 2011. What value does the MPOC-SP have for physiotherapists working with children? Focus group results about family centred care.. Presented at: World Confederation of Physical Therapy Amsterdam, The Netherlands 21-24 June 2011.
2010
- Busse, M. et al. 2010. Utilisation of Healthcare and Associated Services in Huntington's disease: a data mining study. PLoS Currents 3 RRN1206. (10.1371/currents.RRN1206)
- Pickering, D. and Busse, M. 2010. An Audit of disabled children’s services – what value is MPOC-SP?. Clinical Audit 2010 (2), pp.13-22. (10.2147/CA.S8073)
- Pickering, D. and Busse, M. 2010. Disabled children's services: how do we measure family-centred care?. Journal of Child Health Care 14 (2), pp.200-207. (10.1177/1367493509360207)
- Sheeran, L. et al. 2010. Preliminary study: reliability of the spinal wheel. A novel device to measure spinal postures applied to sitting and standing. European Spine Journal 19 (6), pp.995-1003. (10.1007/s00586-009-1241-0)
- Sheeran, L. et al. 2010. Preliminary study: reliability of the spinal wheel. A novel device to measure spinal postures applied to sitting and standing. European Spine Journal 19 (6), pp.995-1003. (10.1007/s00586-009-1241-0)
2009
- Busse, M. and Tyson, S. F. 2009. How many body locations need to be tested when assessing sensation after stroke? An investigation of redundancy in the Rivermead Assessment of Somatosensory Performance. Clinical Rehabilitation 23 (1), pp.91-95. (10.1177/0269215508097296)
- Busse, M. , Van Deursen, R. W. M. and Wiles, C. M. 2009. Real-life step and activity measurement: reliability and validity. Journal of Medical Engineering & Technology 33 (1), pp.33-41. (10.1080/03091900701682606)
- Busse, M. , Wiles, C. M. and Rosser, A. E. 2009. Mobility and falls in people with Huntington's disease. Journal of Neurology Neurosurgery and Psychiatry 80 (1), pp.88-90. (10.1136/jnnp.2008.147793)
- Cooper, A. et al. 2009. The relationship of lower limb muscle strength and joint kinematics during the stance phase of gait in hemiparetic stroke patients [Abstract]. International Journal of Stroke 4 (S2), pp.36-36. (10.1111/j.1747-4949.2009.00354.x)
- Tyson, S. F. et al., 2009. What do acute stroke physiotherapists do to treat postural control and mobility? An exploration of the content of therapy in the UK. Clinical Rehabilitation 23 (11), pp.1051-1055. (10.1177/0269215509334837)
- Tyson, S. F. et al., 2009. What is Bobath? A survey of UK stroke physiotherapists' perceptions of the content of the Bobath concept to treat postural control and mobility problems after stroke. Disability & Rehabilitation 31 (6), pp.448-457. (10.1080/09638280802103621)
- Tyson, S. F. et al., 2009. What treatment packages do UK physiotherapists use to treat postural control and mobility problems after stroke?. Disability & Rehabilitation 31 (18), pp.1494-1500. (10.1080/09638280802627686)
2008
- Busse, M. et al. 2008. Physical therapy intervention for people with Huntington disease. Physical Therapy 88 (7), pp.820-31. (10.2522/ptj.20070346)
- Meaney, A. et al., 2008. Response to a structured exercise programme for Huntington's Disease [Abstract]. Journal of Sport Science 26 (S2), pp.125-126. (10.1080/02640410802306202)
2007
- Busse, M. and Tyson, S. F. 2007. Functional balance and mobility tests in healthy participants: reliability, error and influencing factors. Physiotherapy Research International 12 (4), pp.242-250. (10.1002/pri.383)
- Sparkes, V. , Smith, M. and Busse, M. 2007. Scapular taping in the therapeutic management of subacromial impingement symptoms - exploration of a clinical theory. Physiotherapy Research International 12 (4), pp.203-204. (10.1002/pri.387)
2006
- Busse, M. , Wiles, C. M. and Van Deursen, R. W. M. 2006. Co-activation: its association with weakness and specific neurological pathology. Journal of NeuroEngineering and Rehabilitation 3 (1), pp.26-33. (10.1186/1743-0003-3-26)
- Busse, M. , Wiles, C. M. and Van Deursen, R. W. M. 2006. Community walking activity in neurological disorders with leg weakness. Journal of Neurology Neurosurgery & Psychiatry 77 (3), pp.359-362. (10.1136/jnnp.2005.074294)
2005
- Busse, M. , Wiles, C. M. and Van Deursen, R. W. M. 2005. Muscle co-activation in neurological conditions. Physical Therapy Reviews 10 (4), pp.247-253. (10.1179/108331905X78915)
- Wiles, C. M. et al. 2005. Falls and stumbles in myotonic dystrophy. Journal of Neurology, Neurosurgery and Psychiatry 77 (3), pp.393-396. (10.1136/jnnp.2005.066258)
2004
- Busse, M. et al. 2004. Quantified measurement of activity provides insight into motor function and recovery in neurological disease. Journal of Neurology Neurosurgery & Psychiatry 75 (6), pp.884-8. (10.1136/jnnp.2003.020180)
- Pearson, O. R. et al. 2004. Quantification of walking mobility in neurological disorders. QJM: An International Journal of Medicine 97 (8), pp.463-475. (10.1093/qjmed/hch084)
1998
- Vaughan, C. L. , Subramanian, N. and Busse, M. 1998. Selective dorsal rhizotomy as a treatment option for children with spastic cerebral palsy. Gait and Posture 8 (1), pp.43-59.
Articles
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- Busse, M. and Tyson, S. F. 2009. How many body locations need to be tested when assessing sensation after stroke? An investigation of redundancy in the Rivermead Assessment of Somatosensory Performance. Clinical Rehabilitation 23 (1), pp.91-95. (10.1177/0269215508097296)
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- Mestre, T. A. et al., 2016. Rating scales for behavioural symptoms in Huntington's Disease: critique and recommendations. Movement Disorders 31 (10), pp.1466-1478. (10.1002/mds.26675)
- Metzler-Baddeley, C. et al. 2023. HD-DRUM, a tablet-based drumming training App intervention for people with Huntington Disease: App development study. Journal of Medical Internet Research 2023 (7) e48395. (10.2196/48395)
- Milosevic, S. et al. 2022. Understanding the support experiences of families of children with autism and sensory processing difficulties: A qualitative study.. Health Expectations 25 (3), pp.1118-1130. (10.1111/hex.13465)
- Morgan-Jones, P. et al. 2022. Monitoring and managing lifestyle behaviours using wearable activity trackers: a mixed methods study of views from the Huntington's disease community. JMIR Formative Research 6 (6) e36870. (10.2196/36870)
- Muratori, L. M. et al., 2021. Measures of postural control and mobility during dual-tasking as candidate markers of instability in Huntington's Disease. Human Movement Science 80 102881. (10.1016/j.humov.2021.102881)
- Pearson, O. R. et al. 2004. Quantification of walking mobility in neurological disorders. QJM: An International Journal of Medicine 97 (8), pp.463-475. (10.1093/qjmed/hch084)
- Pickering, D. and Busse, M. 2010. An Audit of disabled children’s services – what value is MPOC-SP?. Clinical Audit 2010 (2), pp.13-22. (10.2147/CA.S8073)
- Pickering, D. and Busse, M. 2010. Disabled children's services: how do we measure family-centred care?. Journal of Child Health Care 14 (2), pp.200-207. (10.1177/1367493509360207)
- Playle, R. et al. 2019. Exercise interventions in Huntington's disease: An individual patient data meta-analysis. Movement Disorders Clinical Practice 6 (7), pp.567-575. (10.1002/mdc3.12809)
- Polgar, S. et al., 2018. Assessing the efficacy of cell transplantation for Parkinson's Disease: a patient-centered approach. Journal of Parkinson's Disease 8 (3), pp.375-383. (10.3233/JPD-181309)
- Potter, C. et al. 2023. Effectiveness and cost-effectiveness of a personalised self-management intervention for living with long covid: protocol for the listen randomised controlled trial. Trials 24 75. (10.1186/s13063-023-07090-w)
- Quinn, L. and Busse, M. 2012. Physiotherapy clinical guidelines for Huntington’s disease. Neurodegenerative Disease Management 2 (1), pp.21-31. (10.2217/nmt.11.86)
- Quinn, L. , Busse, M. and Dal Bello-Haas, V. 2013. Management of upper extremity dysfunction in people with Parkinson disease and Huntington disease: facilitating outcomes across the disease lifespan. Journal of Hand Therapy 26 (2), pp.148-155. (10.1016/j.jht.2012.11.001)
- Quinn, L. , Busse, M. and Rosser, A. E. 2013. Critical features in the development of exercise-based interventions for people with Huntington's disease. European Neurological Review 8 (1), pp.10-13.
- Quinn, L. et al. 2017. Physical therapy and exercise interventions in Huntington's disease: a mixed methods systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports 15 (7), pp.1783-4433. (10.11124/JBISRIR-2016-003274)
- Quinn, L. et al. 2020. Clinical recommendations to guide physical therapy practice for Huntington disease. Neurology 94 (5), pp.217-228. (10.1212/WNL.0000000000008887)
- Quinn, L. et al. 2013. Reliability and minimal detectable change of physical performance measures in individuals with pre-manifest and manifest Huntington disease. Physical Therapy 93 (7), pp.942-956. (10.2522/ptj.20130032)
- Quinn, L. et al. 2022. Physical activity and exercise outcomes in Huntington's disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington's disease. Parkinsonism & Related Disorders 101 , pp.75-89. (10.1016/j.parkreldis.2022.06.013)
- Quinn, L. et al. 2016. Development and delivery of a physical activity intervention for people with Huntington Disease. Journal of Neurologic Physical Therapy 40 (2), pp.71-80. (10.1097/NPT.0000000000000119)
- Randell, E. et al. 2024. Exploring critical intervention features and trial processes in the evaluation of sensory integration therapy for autistic children. BMC Trials 25 (1) 131. (10.1186/s13063-024-07957-6)
- Randell, E. et al. 2019. Sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children: study protocol for a pragmatic randomised controlled trial.. Trials 20 113. (10.1186/s13063-019-3205-y)
- Randell, E. et al. 2022. Sensory integration therapy for children with autism and sensory processing difficulties: the SenITA RCT. Health Technology Assessment 26 (29)(10.3310/TQGE0020)
- Read, J. et al., 2012. I03 Evaluation of life time physical activity levels in Huntington's disease [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83 (S1), pp.A33. (10.1136/jnnp-2012-303524.102)
- Rosser, A. E. et al. 2022. Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder. Brain 145 (5), pp.1584-1597. (10.1093/brain/awac086)
- Sheeran, L. et al. 2010. Preliminary study: reliability of the spinal wheel. A novel device to measure spinal postures applied to sitting and standing. European Spine Journal 19 (6), pp.995-1003. (10.1007/s00586-009-1241-0)
- Sheeran, L. et al. 2010. Preliminary study: reliability of the spinal wheel. A novel device to measure spinal postures applied to sitting and standing. European Spine Journal 19 (6), pp.995-1003. (10.1007/s00586-009-1241-0)
- Simpson, S. et al. 2021. Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum. International Journal of Obesity 45 , pp.1728-1739. (10.1038/s41366-021-00835-0)
- Sparkes, V. , Smith, M. and Busse, M. 2007. Scapular taping in the therapeutic management of subacromial impingement symptoms - exploration of a clinical theory. Physiotherapy Research International 12 (4), pp.203-204. (10.1002/pri.387)
- Steventon, J. et al. 2020. Altered cerebrovascular response to acute exercise in patients with Huntington’s Disease. Brain Communications 2 (1) fcaa044. (10.1093/braincomms/fcaa044)
- Townhill, J. et al. 2016. Using Actiwatch to monitor circadian rhythm disturbance in Huntington' disease: A cautionary note. Journal of Neuroscience Methods 265 , pp.13-18. (10.1016/j.jneumeth.2016.01.009)
- Tyson, S. F. et al., 2009. What do acute stroke physiotherapists do to treat postural control and mobility? An exploration of the content of therapy in the UK. Clinical Rehabilitation 23 (11), pp.1051-1055. (10.1177/0269215509334837)
- Tyson, S. F. et al., 2009. What is Bobath? A survey of UK stroke physiotherapists' perceptions of the content of the Bobath concept to treat postural control and mobility problems after stroke. Disability & Rehabilitation 31 (6), pp.448-457. (10.1080/09638280802103621)
- Tyson, S. F. et al., 2009. What treatment packages do UK physiotherapists use to treat postural control and mobility problems after stroke?. Disability & Rehabilitation 31 (18), pp.1494-1500. (10.1080/09638280802627686)
- Vaughan, C. L. , Subramanian, N. and Busse, M. 1998. Selective dorsal rhizotomy as a treatment option for children with spastic cerebral palsy. Gait and Posture 8 (1), pp.43-59.
- Watt, F. E. et al., 2019. Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury. Osteoarthritis and Cartilage 27 (1), pp.23-33. (10.1016/j.joca.2018.08.001)
- Wiles, C. M. et al. 2005. Falls and stumbles in myotonic dystrophy. Journal of Neurology, Neurosurgery and Psychiatry 77 (3), pp.393-396. (10.1136/jnnp.2005.066258)
- Williams, N. et al. 2025. Effectiveness of a community-based rehabilitation programme following hip fracture: results from the Fracture in the Elderly Multidisciplinary Rehabilitation - phase III (FEMuR III) randomised. BMJ Open 15 e091603. (10.1136/bmjopen-2024-091603)
- Williams, N. et al., 2020. Protocol for a definitive randomised controlled trial and economic evaluation of a community-based rehabilitation programme following hip fracture: fracture in the elderly multidisciplinary rehabilitation—phase III (FEMuR III). BMJ Open 10 e039791. (10.1136/bmjopen-2020-039791)
- Woodgate, S. et al. 2021. Objectively characterizing Huntington’s disease using a novel upper limb dexterity test. Journal of Neurology 268 , pp.2550-2559. (10.1007/s00415-020-10375-8)
- Yhnell, E. et al. 2018. Exploring computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD): protocol for a randomised feasibility study. Pilot and Feasibility Studies 4 45. (10.1186/s40814-018-0237-0)
- Yhnell, E. et al. 2020. A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD). Pilot and Feasibility Studies 6 88. (10.1186/s40814-020-00623-z)
Book sections
- Clinch, S. et al. 2017. Rehabilitation training in neural restitution. In: Dunnett, S. B. and Bjorklund, A. eds. Progress in Brain Research. Vol. 230, Elsevier. , pp.305-329. (10.1016/bs.pbr.2016.12.006)
- Drew, C. J. and Busse, M. 2022. Considerations for clinical trial design and conduct in the evaluation of novel advanced therapeutics in neurodegenerative disease. In: Lane, E. , Cheney, D. and Lelos, M. eds. Current Challenges in Cell Therapy for Neurodegenerative Diseases. International Review of Neurobiology Elsevier. , pp.235-279. (10.1016/bs.irn.2022.09.006)
- Quinn, L. and Busse, M. 2017. The role of rehabilitation therapy in Huntington disease. In: Feigen, A. S. and Anderson, K. E. eds. Handbook of Clinical Neurology: Huntington Disease. Vol. 144, Elsevier: Monograph Series. , pp.151-165. (10.1016/B978-0-12-801893-4.00013-4)
Conferences
- Button, K. et al. 2018. An evaluation of TRAK physiotherapy self management intervention development and delivery for knee conditions. Presented at: OARSI 2018 World Congress on Osteoarthritis Liverpool 26-29 April 2018. , pp.-.
- Drew, C. J. et al. 2022. F21 Co-design of a lifestyle intervention to improve quality of life in Huntington's disease. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September 2022. Vol. 93.BMJ Publishing Group. (10.1136/jnnp-2022-ehdn.112)
- Fahed, V. S. et al., 2022. F52 Acoustic voice features in Huntington's disease in native English, Spanish and Polish speakers. Presented at: EHDN 2022 Plenary Meeting 16-18 September 2022. Vol. 93.BMJ Publishing Group. (10.1136/jnnp-2022-ehdn.143)
- Griffiths, A. , Busse, M. and Sarin, B. 2012. Do the understanding, knowledge and fears of the caregivers of first time stroke survivors accurately reflect the difficulties faced after discharge from hospital?. Presented at: Welsh Stroke Conference 2012 Newport, Wales 22nd June 2012.
- Lozano-García, M. et al., 2022. F61 Validation of a gait event detection algorithm during overground walking in Huntington's disease. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September 2022. Vol. 93.BMJ Publishing Group. (10.1136/jnnp-2022-ehdn.152)
- Mann, E. et al., 2022. F62 Validation of digital assessment of physical activity in Huntington’s disease: comparing fitbit charge 4 step count with research-grade accelerometers. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September 2022. BMJ Publishing Group. , pp.A58-A59. (10.1136/jnnp-2022-ehdn.153)
- Markoulidakis, A. et al. 2022. Lifestyle index for individuals with HD (LifeHD): an aggregated measure that characterises the lifestyle habits of individuals with HD. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September. Vol. 93.Vol. S1. (10.1136/jnnp-2022-ehdn.111)
- Metzler-Baddeley, C. et al. 2022. HD-DRUM – a novel computerised drumming training for movement and cognitive abilities in people with Huntington’s disease – app development and protocol of a randomised controlled feasibility study. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September 2022. Vol. 93.Vol. S1. , pp.A100-A101. (10.1136/jnnp-2022-ehdn.267)
- Pickering, D. and Busse, M. 2011. What value does the MPOC-SP have for physiotherapists working with children? Focus group results about family centred care.. Presented at: World Confederation of Physical Therapy Amsterdam, The Netherlands 21-24 June 2011.
Websites
- Ioakeimidis, V. et al. 2023. Protocol for a randomised controlled feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington's disease. [Online].medRxiv: medRxiv. (10.1101/2023.11.15.23298581)Available at: https://doi.org/10.1101/2023.11.15.23298581.
- Ioakeimidis, V. et al. 2025. In vivo mapping of striatal microstructure in Huntington's disease with Soma and Neurite Density Imaging. [Online].MedRxiv: MedRxiv. Available at: https://www.medrxiv.org/content/10.1101/2025.03.17.25324107v1.
- Markoulidakis, A. et al. 2020. A tutorial comparing different covariate balancing methods with an application evaluating the causal effect of exercise on the progression of Huntington’s disease. [Online].arXiv. Available at: https://arxiv.org/abs/2010.09563.
- Metzler-Baddeley, C. et al. 2023. Applying an integrated knowledge translation framework approach to develop a tablet-based rhythmic movement training intervention for people with Huntington’s disease. [Online].JMIR Preprints. (10.2196/preprints.48395)Available at: https://preprints.jmir.org/preprint/48395.
Research
Research Grants
2025
NIHR HTA. £2,516,083. Shoulder Replacement Prehabilitation and Rehabilitating Early (SPRING).
2023
Health and Care Research Wales Health Research. £217,426. Developing Peer Led Movement-based Intervention to Improve Physical and Psychological Outcomes for Survivors of Torture and Trauma in Wales and Beyond (Peer-MIST).
GW4 Generator Fund. £19,643.00. GW4 community studying fatigue in people with multiple long-term conditions.
2022
UKRI Zinc Catalyst Award. £62,550.00. Catalysing the TIPTOE self-management intervention for older adults with osteoarthritis and multiple long term conditions into practice.
NIHR HTA. £1,715,355.77. MulTI-domain Self-management in Older People wiTh OstEoarthritis and Multi-Morbidities.
Wellcome Trust –Translation of Concept Scheme (Institutional Translational Partnership Award (ITPA). £24,137. AcceSSIbleSofTware to Accelerate Non-commercial Trials for rapid patient impact.
2021
GBHI, Alzheimer’s Association and Alzheimer’s Society UK Pilots Award. £ 19,000. The development of resources to support the remote delivery of a physiotherapy intervention in traumatized refugees in Jordan.
Health and Care Research Wales Research for Public and Patient Benefit. £ 227317.00. Feasibility of TRAK-MSK, a digital self-management physiotherapy intervention, for people with musculoskeletal conditions.
Innovation for All. £24016.00. Co-design of a self-management workbook and training for older or adults with multi-morbidities and osteoarthritis.
Innovation for All. £20113.50. Creating the next generation of Huntington’s Disease Physical activity champions.
NIHR Long COVID in non-hospitalised individuals Call. £1,055,520.00. Long Covid Personalised Self-managemenT support- co-design and EvaluatioN.
Wellcome Trust –Translation of Concept Scheme (Institutional Translational Partnership Award (ITPA). £19,648. Guided Self-Help Movement-based Intervention to Improve Physical and Psychological Outcomes for Survivors of Torture and Trauma in Wales and Beyond.
2020
Wellcome Trust Public Engagement Coproduction Award. £14825.00. Get cre-active – using the creative arts to explore challenges to physical activity for people with hip dysplasia.
2019
JPND Multinational research projects on Health and Social Care for Neurodegenerative Diseases. €2,049,523.75. Multi-Domain Lifestyle Targets for Improving ProgNOsis in Huntington’s Disease
Health and Care Research Wales. £2,470,489.00. Centre for Trials Research Infrastructure renewal.
Health and Care Research Wales. Social Care Fellowship. £392,912.00. Feading, Eating and Drinking in Neurological Care: Sharing Practice to Transform Care (mentor).
Health and Care Research Wales. Social Care Fellowship. £414,349.00. A longitudinal investigation of new ‘Smart Speaker’ personal assistants to improve independence and wellbeing in social care settings (mentor).
ROCHE Pharmaceuticals. BN 40422. Natural History Study. Principal Investigator. £58,766.00.
ROCHE Pharmaceuticals. BN 40423. Pivotal Trial. Sub-investigator. £64,701.00.
ROCHE Pharmaceuticals. £42,020.00. GenExtend. Sub-investigator. BN40955.
2018
Engineering and Physical Sciences Research Council. £29,986. AuTomated prioRitisation and categorIsation of sAfety and PharmacoviGilance Events in CTIMPs.
Health and Care Research Wales Research for Public and Patient Benefit. £229866.00. Treating Anxiety to PrevEnt Relapse in Schizophrenia - a feasibility trial.
NIHR PGfAR. £99889.00. Programme Development Grant. PARC: A self-management intervention to support Physical Activity for people with Rare neurological Conditions
NIHR HTA. £2 144 709.00. A definitive multi-centre randomised controlled trial and economic evaluation of a community-based rehabilitation package following hip fracture.
Health and Care Research Wales. £1,733,333. South East Wales Trials Unit/ Centre for Trials Research Infrastructure funding.
Health and Care Research Wales. £806,983. BRAIN unit Infrastructure funding.
2017
NIHR HTA. £1,193 million. A Pragmatic Randomised Controlled Trial of Sensory Integration Therapy versus usual care for sensory processing difficulties in Autism Spectrum Disorder in children: impact on behavioural difficulties, adaptive skills and socialisation
Multiple Sclerosis Society. £298509.00. Life-style, Exercise and Activity Package for People living with Progressive Multiple Sclerosis.
Jacques and Gloria Gossweiler Foundation Research Grants in the field of Neurology. £411 00.00. Physical Activity and Exercise Outcomes in Huntington's Disease.
Research for Public and Patient Benefit. £223132.00. Trial designs for Delivery of Novel Therapies for Neurodegeneration.
Huntington's Disease Association of England and Wales. £10 300.00. Promotion of physical activity in Huntington's Disease clinics.
2016
MRC Confidence in Concept. £39,490. Using wearable technology to predict perioperative high-risk patient outcomes.
MRC Confidence in Concept. £49,902.00. Developing clinical applications for a novel multi-task functional assessment.
Wellcome Trust ISSF Cross disciplinary awards. £8,935. Pilot study of motor coordination disorder in 22q11.2 deletion syndrome.
Wellcome Trust ISSF Cross disciplinary awards. £47,945. Automated assessment of timing and movement signatures in Huntington’s Disease.
Wellcome Trust ISSF ISSF populations pilot awards. £28,414. Feasibility of using consumer-targeted activity monitors in collecting physical activity data within the HealthWise Wales cohort: a pragmatic pilot study.
Jacques and Gloria Gossweiler Foundation Research Grants in the field of Neurology. £94,071. Exploring cognitive training as a non-pharmaceutical intervention for people with Huntingtons disease (mentor).
2015
Division of Health and Care Research Wales. £1.2m. Brain Repair And Intracranial Neurotherapeutics- Wales BRAIN Unit.
2013
FP7-HEALTH-2013-INNOVATION-1. £1,705,800. REPAIR-HD Human pluripotent stem cell differentiation, safety and preparation for therapeutic transplantation in Huntington's disease.
Jacques and Gloria Gossweiler Foundation. £172,805. ExeRT-HD Exercise Rehabilitation Trial in Huntington's Disease.
National Institute of Social Care and Health Research/ National Institute of Health Research. £687,362. Move to Exercise: Home based exercise for people with Huntington's Disease.
2012
Wellcome Trust ISSF Seedcorn £45,000. Real Time fMRI neurofeedback as a treatment for Parkinson's Disease.
2011
Neil Glendinning Research Grant Huntington's Disease Association. £99,230. Task Training in Huntington's Disease.
European Huntington's Disease Network. £38,384. Feasibility and benefit of inspiratory muscle training in people with Huntington's disease.
2010
National Institute for Social Care and Health Research Health Research Funding Scheme. £122,720. Can community supported exercise benefit subjective wellbeing, physical activity levels and abilities in people with Huntington's disease? A randomised feasibility study and process evaluation.
Medical Research Council. National Prevention Research Initiative. £1,041,422.Health Eating and Lifestyle in Pregnancy Study (HELP).
2009
European Huntington's Disease Network. £36,000. Reliability and minimal detectable change of measures of participation, functional activities and impairments in individuals with Huntington's disease.
Physiotherapy Research Foundation Scheme B. £6,500.Respiratory Function in people with Huntington's disease: a cross sectional study.
Research Capacity Building Consortium Wales PhD studentship. £51,558. Respiratory Function in people with Huntington's disease: a cross sectional study.
2008
Chief Medical Officer for Wales Research Budget. £9,938. Development and evaluation of a DVD resource for people with a neurodegenerative disease who may be at risk of falls.
Paul Jeffries Waters Bequest Fund to support research in Huntington' disease. £2,820.
2007
Physiotherapy Research Society. £500. Mobility and Falls in Huntington's Disease.
Teaching
I hold a Post Graduate Certificate in Teaching and Learning in Higher Education, a Certificate in Teaching Statistics in Higher Education (Royal Statistical Society) and a Post Graduate Diploma in Clinical Trials (LSHTM). My research related teaching has a clear focus on development and evaluation of complex interventions in clinical settings and applied health research methods.
My approach to teaching, learning and assessment is grounded in both theoretical understanding and extensive practical experience across multiple educational contexts. As a Fellow of the Higher Education Academy (2000), I have demonstrated sustained commitment to pedagogical excellence and innovation throughout my career.
I have designed and delivered specialist training across undergraduate and postgraduate education in multiple health and social care disciplines, developing comprehensive understanding of diverse learning approaches. My teaching experience spans traditional classroom settings, clinical environments, and digital learning platforms, providing insights into effective pedagogical approaches across varied contexts.
My educational philosophy emphasises the importance of tailoring teaching and assessment methods to individual learning needs while maintaining academic rigour. I have implemented innovative assessment methodologies that enhance student progression across diverse cohorts, recognising that effective assessment must balance formative development with summative evaluation. This approach has consistently resulted in enhanced student satisfaction and engagement metrics.
I have led curriculum design initiatives that respond to evolving professional landscapes, ensuring that educational provision remains aligned with employability requirements while maintaining academic integrity. My experience supervising over 30 undergraduate dissertations, 10 Master's dissertations, and nine PhDs has developed my understanding of effective supervision practices and their impact on student achievement.
Throughout my career, I have championed the strategic integration of learning technologies to enhance educational quality and accessibility. My leadership in developing blended learning approaches has balanced digital innovation with sound pedagogical principles, ensuring that technology serves rather than drives educational objectives.
I am committed to evidence-based approaches to evaluating teaching effectiveness, implementing comprehensive quality enhancement frameworks that utilise both quantitative and qualitative indicators. This data-driven approach to educational improvement has resulted in measurable enhancements to student satisfaction and learning outcomes throughout my career.
Biography
Qualifications
I was awarded my Bachelor of Science in Physiotherapy in 1993 from the University of Stellenbosch, South Africa. After graduation, I worked clinically as well as in clinical supervision in university settings in South Africa, USA and UK for more than 10 years as well as undertaking further studies in Ergonomics and Biomechanics. I was awarded my BSc (Med) Hons. Ergonomics (first class) from the University of Cape Town) in December 1996 and my MSc (Med) Biomedical Sciences (distinction) from the University of Cape Town), South Africa in December 2001.
In 2002, I registered for a full time PhD at the University of Wales College of Medicine in Cardiff and was awarded my PhD in 2005. I have worked as a Lecturer, Senior lecturer, Reader and then Professor at Cardiff University since 2005.
I was awarded a Post Graduate Certificate in Teaching and Learning (Kingston University) in July 2001, a Diploma in Research Methods (University of Wales College of Medicine) in May 2003, a Post Graduate Certificate in Teaching Statistics in Higher Education (Royal Statistical Society) in February 2005 and a Post Graduate Diploma in Clinical Trials (London School of Hygiene and Tropical Medicine) in July 2017. I am a qualified Executive Coach (Level 7 Institute of Leadership and Management) and Certified Insights Practitioner.
Honours and awards
Fellow of Learned Society of Wales April 2021
Professional memberships
Registered Physiotherapist Health Professions Council PH 53577 January 1998
Member of Chartered Society of Physiotherapy January 1998
Fellow of Higher Education Institute July 2001
Academic positions
2022 ongoing Director Health and Care Research Wales Faculty.
2016 to 2022 Director Mind Brain Neuroscience Trials, Centre for Trials Research, Cardiff University, UK.
2015 to 2016 Deputy Head of School of Healthcare Sciences: Research and Innovation, Cardiff University UK
2014 to 2016 Professor of Healthcare Sciences, Associate Director South East Wales Trials Unit
2010 to 2014 Senior Lecturer: School of Healthcare Sciences, Cardiff University, UK
2005 to 2010 Lecturer: School of Healthcare Studies, Cardiff University, UK
Committees and reviewing
2025. 4Ward North PhD Programme for Health Professionals. External Interview Panel Member.
2024. Oversight Group Chair for the Steering Committee NIHR155936 - Comprehensive geriatric assessment to sustain independence for older people living with heart failure with preserved ejection fraction and frailty
2023. Community Rehabilitation NIHR Incubator Hub Steering Group.
2023-2026. NIHR Advanced Fellowship Selection Committee.
2022. Wellcome GW4-CAT HP Programme - Senior Supervisor.
2021/2/3. Future Leaders Fellows Development Networks’ Mentor 2021/22/23 cycle.
2022. Member of the STEMM1 (Medicine and Medical Sciences) Learned Society Scrutiny committee.
2021-2025. Member MRC Clinical Fellowships Panel.
2021-2024. Member of NIHR HTA Commissioning Funding panel.
2020. Advisory board for Health and Care Economics Cymru (HCEC).
2020. Invited member DHSC/UKRI COVID-19 rapid response rolling call – College of Experts.
2019. Member of CRUK Time for Research Project Steering Committee.
2019-2021. Member of NIHR Dementias Portfolio Development Group.
2018-2023. Chair of Trial Steering Committee for NIHR HTA 16/31/63 RCT of Specialist Physiotherapy for Functional Motor Disorder.
2018-2022. Chair of Trial Steering Committee for MRC funded AIMM (Acipimox in Mitochondrial Myopathy) trial.
2018-2022. Elected member of the global Enroll-HD Scientific Planning Committee.
2018-2022. Invited member of the European Huntington’s Disease Network (EHDN) Clinical Trials Taskforce
2018-2022. Member of NIHR Clinical Trials Unit Standing Advisory Committee.
2015-2018. Member of Ataxia UK Scientific Board.
2015-2018. Invited member of Movement Disorder Society task force on rating scales in Huntington's disease.
2015-2017. Elected member EHDN Scientific & Bioethics Advisory Board.
2010-2015. Member of the Dementia, Neurodegenerative Diseases Research (DeNDRoN) HD Clinical Studies Group and Portfolio Management Group.
2010-2015. Member of NEURODEM Cymru, the Wales Dementias and Neurodegenerative Diseases Registered Research Group. Steering Committee.
Supervisions
I have supervised projects in:
- Clinical Evaluation of Physical Activity and Sleep in neurodegenerative disease
- Complex interventions and self-management support
- Digital health interventions applied to long term conditions
- Mixed methods applied health research
Completed PhD supervisions
Movement Deficits and Physiotherapy Huntington's disease. Awarded 2013. Hanan Khalil
A comparative analysis of physiotherapy services in different health environments. Awarded 2014. Abdulrahman Altowaijri.
Respiratory Function in people with Huntington's disease: a cross-sectional study. Awarded 2014. Una Jones
Training the Brain in Huntington's Disease. Awarded 2017. Susanne Clinch.
An exploration of Exercise Experiences in People with Huntington's disease: Who makes the time? Awarded 2019. Katy Hamana
Exploring clinical applications for a novel multi-task functional assessment: matching appropriate technology to clinical need. Awarded 2021. Samuel Woodgate.
“A Window of Opportunity.” Describing and Developing an Evidence, Theory, and Practice-Informed Occupational Therapy Intervention for People Living with Early-Stage Dementia. Awarded 2022. Bethan Mair Edwards.
Understanding multi-party communication in therapy sessions for children with Autism Spectrum Disorder and Sensory Processing difficulties - the value of interaction analysis. Awarded 2024. Eleni Glarou.
Identification and modelling of causal genetic and environmental factors for HD severity and progression. Awarded 2024. Andreas Markoulidakis.
Engagement
As an executive coach and committed mentor of early and mid-career applied health researchers, I engage broadly in the allied health professional researcher development arena. I have been a mentor in the Future Leaders Fellows Development Networks’ Mentor 2021/22 and 2022/23 cycle and develop and deliver mentoring training for researchers working in applied health and social care research settings. I am an accredited Insights Practitioner and utilise this in a variety of researcher development initiatives specific to applied health and social care research. In my capacity of Director of Health and Care Research Wales Faculty, I am leading the strategic response to the Review of Research Careers in Wales jointly commissioned by Health and Care Research Wales, Social Care Wales and Health Education and Improvement Wales. I am a member of the Clinical Academic Training Forum Gender Inequalities Monitoring Principles and Obligations Working Group and the Council for Allied Health Professions Research.
I am a past elected member of the European Huntington’s Disease Executive Committee, an independent not for profit network dedicated to advancing research, conducting clinical trials and improving care for people affected by Huntington’s Disease. I have chaired plenary sessions at the past three European Plenary meetings, been a member of the Enroll-HD Scientific Review Committee, The Scientific and Ethics Bio advisory Group and a co-lead facilitator of the European Huntington's Disease Network (EHDN) physiotherapy working group where I was active in organising international group meetings for more than 6 years leading to established collaborations across the United Kingdom, Europe, USA and Australia. These collaborations have led to the publication of the first ever evidence informed clinical guidance for the management of physiotherapy for Huntington’s. These internationally recognised guidelines were published in Journal for Neurology in 2020. As a representative of the Cardiff Huntington's Disease clinic and Clinical Lead for Physiotherapy, I have spoken both locally and internationally on family days for people with HD where provision of knowledge and development of awareness may directly impact on a person's ability to cope with this particular long term neurological condition. I organised the highly successful Cardiff Huntington’s Disease Research Management Clinic Open days for 6 consecutive years and remain an active contributor to the event. I have been instrumental in establishing a Wales Huntington's Disease Involving People Group. This group is now joined with the Wales BRAIN unit, BRAIN Involve.
