Darren Cameron
Timau a rolau for Darren Cameron
Uwch Biowybodeg a Pheiriannydd Meddalwedd Ymchwil
Trosolwyg
Rwy'n biowybodeg a pheiriannydd meddalwedd ymchwil sy'n arbenigo mewn dadansoddi setiau data genomeg un cell a swyddogaethol ar raddfa fawr. Mae fy ymchwil yn defnyddio dulliau fel dilyniannu un niwclews (snRNA-seq / snATAC-seq) a mapio eQTL ochr yn ochr â data genetig amrywiolyn cyffredin a phrin i nodi'r mathau o gelloedd a'r mecanweithiau rheoleiddio sy'n gysylltiedig ag anhwylderau niwroseiciatrig.
Yn ogystal ag ymchwil genomig, rwy'n datblygu seilwaith cyfrifiadurol graddadwy ac atgynhyrchadwy ar gyfer data biolegol dimensiwn uchel. Mae hyn yn cynnwys adeiladu piblinellau biowybodeg modiwlaidd ac offer meddalwedd sydd wedi'u cynllunio i'w defnyddio ar amgylcheddau cyfrifiadura perfformiad uchel (HPC).
GitHub: dolen.
Cyhoeddiad
2026
- Baran, Y. et al. 2026. Spatial mapping of genetic liability to psychiatric disorders in the adult human hippocampus. Biological Society: Global Open Science 6 (3) 100719. (10.1016/j.bpsgos.2026.100719)
- Cameron, D. et al. 2026. Developmental, neuroanatomical and cellular expression of genes causing dystonia. Annals of Clinical and Translational Neurology 13 (5), pp.1005-1019. (10.1002/acn3.70285)
2025
- Richards, A. L. et al. 2025. Effects of shared and nonshared schizophrenia and bipolar disorder alleles on cognition and educational attainment in the UK Biobank. Biological Society: Global Open Science 5 (6) 100601. (10.1016/j.bpsgos.2025.100601)
2024
- Cameron, D. et al. 2024. Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia. Schizophrenia Bulletin Open 50 (5), pp.1171-1184. (10.1093/schbul/sbae083)
- Tume, C. E. et al. 2024. Genetic implication of specific glutamatergic neurons of the prefrontal cortex in the pathophysiology of schizophrenia. Biological Psychiatry 4 (5) 100345. (10.1016/j.bpsgos.2024.100345)
2023
- Cameron, D. et al. 2023. Single nuclei RNA sequencing of 5 regions of the human prenatal brain implicates developing neuron populations in genetic risk for schizophrenia. Biological Psychiatry 93 , pp.157-166. (10.1016/j.biopsych.2022.06.033)
2021
- Kouakou, M. et al., 2021. Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186 (6), pp.376-388. (10.1002/ajmg.b.32877)
2019
- Cameron, D. et al. 2019. Transcriptional changes following cellular knockdown of the schizophrenia risk gene SETD1A are enriched for common variant association with the disorder. Molecular Neuropsychiatry 5 (2), pp.109-114. (10.1159/000497181)
- Cameron, D. 2019. Gene regulation in microglia and genetic risk for complex brain disorders. PhD Thesis , Cardiff University.
2018
- Pardinas, A. F. et al. 2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics 50 , pp.381-389. (10.1038/s41588-018-0059-2)
- Tansey, K. E. , Cameron, D. and Hill, M. J. 2018. Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks. Genome Medicine 10 14. (10.1186/s13073-018-0523-8)
2017
- Clifton, N. et al. 2017. Hippocampal regulation of postsynaptic density Homer1 by associative learning. Neural Plasticity 2017 5959182. (10.1155/2017/5959182)
2016
Erthyglau
- Baran, Y. et al. 2026. Spatial mapping of genetic liability to psychiatric disorders in the adult human hippocampus. Biological Society: Global Open Science 6 (3) 100719. (10.1016/j.bpsgos.2026.100719)
- Cameron, D. et al. 2026. Developmental, neuroanatomical and cellular expression of genes causing dystonia. Annals of Clinical and Translational Neurology 13 (5), pp.1005-1019. (10.1002/acn3.70285)
- Richards, A. L. et al. 2025. Effects of shared and nonshared schizophrenia and bipolar disorder alleles on cognition and educational attainment in the UK Biobank. Biological Society: Global Open Science 5 (6) 100601. (10.1016/j.bpsgos.2025.100601)
- Cameron, D. et al. 2024. Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia. Schizophrenia Bulletin Open 50 (5), pp.1171-1184. (10.1093/schbul/sbae083)
- Tume, C. E. et al. 2024. Genetic implication of specific glutamatergic neurons of the prefrontal cortex in the pathophysiology of schizophrenia. Biological Psychiatry 4 (5) 100345. (10.1016/j.bpsgos.2024.100345)
- Cameron, D. et al. 2023. Single nuclei RNA sequencing of 5 regions of the human prenatal brain implicates developing neuron populations in genetic risk for schizophrenia. Biological Psychiatry 93 , pp.157-166. (10.1016/j.biopsych.2022.06.033)
- Kouakou, M. et al., 2021. Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186 (6), pp.376-388. (10.1002/ajmg.b.32877)
- Cameron, D. et al. 2019. Transcriptional changes following cellular knockdown of the schizophrenia risk gene SETD1A are enriched for common variant association with the disorder. Molecular Neuropsychiatry 5 (2), pp.109-114. (10.1159/000497181)
- Pardinas, A. F. et al. 2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics 50 , pp.381-389. (10.1038/s41588-018-0059-2)
- Tansey, K. E. , Cameron, D. and Hill, M. J. 2018. Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks. Genome Medicine 10 14. (10.1186/s13073-018-0523-8)
- Clifton, N. et al. 2017. Hippocampal regulation of postsynaptic density Homer1 by associative learning. Neural Plasticity 2017 5959182. (10.1155/2017/5959182)
- Pardinas, A. et al. 2016. Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection. bioRxiv (10.1101/068593)
Gosodiad
- Cameron, D. 2019. Gene regulation in microglia and genetic risk for complex brain disorders. PhD Thesis , Cardiff University.
Bywgraffiad
Rwy'n biowybodeg a pheiriannydd meddalwedd ymchwil sy'n arbenigo mewn dadansoddi setiau data genomeg un cell a swyddogaethol ar raddfa fawr. Mae fy ymchwil yn defnyddio dulliau fel dilyniannu un niwclews (snRNA-seq / snATAC-seq) a mapio eQTL ochr yn ochr â data genetig amrywiolyn cyffredin a phrin i nodi'r mathau o gelloedd a'r mecanweithiau rheoleiddio sy'n gysylltiedig ag anhwylderau niwroseiciatrig.
Yn ogystal ag ymchwil genomig, rwy'n datblygu seilwaith cyfrifiadurol graddadwy ac atgynhyrchadwy ar gyfer data biolegol dimensiwn uchel. Mae hyn yn cynnwys adeiladu piblinellau biowybodeg modiwlaidd ac offer meddalwedd sydd wedi'u cynllunio i'w defnyddio ar amgylcheddau cyfrifiadura perfformiad uchel (HPC).
GitHub: dolen.
Meysydd goruchwyliaeth
Goruchwyliaeth gyfredol
Yusuf Baran