Darren Cameron
Teams and roles for Darren Cameron
Senior Bioinformatician & Research Software Engineer
Overview
I am a bioinformatician and research software engineer specialising in the analysis of large-scale single-cell and functional genomics datasets. My research utilises modalities such as single-nucleus sequencing (snRNA-seq/snATAC-seq) and eQTL mapping alongside common and rare variant genetic data to identify the cell types and regulatory mechanisms implicated in neuropsychiatric disorders.
In addition to genomic research, I develop scalable and reproducible computational infrastructure for high-dimensional biological data. This involves building modular bioinformatics pipelines and software tools designed for deployment on high-performance computing (HPC) environments.
GitHub: link.
Publication
2026
- Baran, Y. et al. 2026. Spatial mapping of genetic liability to psychiatric disorders in the adult human hippocampus. Biological Society: Global Open Science 6 (3) 100719. (10.1016/j.bpsgos.2026.100719)
- Cameron, D. et al. 2026. Developmental, neuroanatomical and cellular expression of genes causing dystonia. Annals of Clinical and Translational Neurology 13 (5), pp.1005-1019. (10.1002/acn3.70285)
2025
- Richards, A. L. et al. 2025. Effects of shared and nonshared schizophrenia and bipolar disorder alleles on cognition and educational attainment in the UK Biobank. Biological Society: Global Open Science 5 (6) 100601. (10.1016/j.bpsgos.2025.100601)
2024
- Cameron, D. et al. 2024. Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia. Schizophrenia Bulletin Open 50 (5), pp.1171-1184. (10.1093/schbul/sbae083)
- Tume, C. E. et al. 2024. Genetic implication of specific glutamatergic neurons of the prefrontal cortex in the pathophysiology of schizophrenia. Biological Psychiatry 4 (5) 100345. (10.1016/j.bpsgos.2024.100345)
2023
- Cameron, D. et al. 2023. Single nuclei RNA sequencing of 5 regions of the human prenatal brain implicates developing neuron populations in genetic risk for schizophrenia. Biological Psychiatry 93 , pp.157-166. (10.1016/j.biopsych.2022.06.033)
2021
- Kouakou, M. et al., 2021. Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186 (6), pp.376-388. (10.1002/ajmg.b.32877)
2019
- Cameron, D. et al. 2019. Transcriptional changes following cellular knockdown of the schizophrenia risk gene SETD1A are enriched for common variant association with the disorder. Molecular Neuropsychiatry 5 (2), pp.109-114. (10.1159/000497181)
- Cameron, D. 2019. Gene regulation in microglia and genetic risk for complex brain disorders. PhD Thesis , Cardiff University.
2018
- Pardinas, A. F. et al. 2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics 50 , pp.381-389. (10.1038/s41588-018-0059-2)
- Tansey, K. E. , Cameron, D. and Hill, M. J. 2018. Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks. Genome Medicine 10 14. (10.1186/s13073-018-0523-8)
2017
- Clifton, N. et al. 2017. Hippocampal regulation of postsynaptic density Homer1 by associative learning. Neural Plasticity 2017 5959182. (10.1155/2017/5959182)
2016
Articles
- Baran, Y. et al. 2026. Spatial mapping of genetic liability to psychiatric disorders in the adult human hippocampus. Biological Society: Global Open Science 6 (3) 100719. (10.1016/j.bpsgos.2026.100719)
- Cameron, D. et al. 2026. Developmental, neuroanatomical and cellular expression of genes causing dystonia. Annals of Clinical and Translational Neurology 13 (5), pp.1005-1019. (10.1002/acn3.70285)
- Richards, A. L. et al. 2025. Effects of shared and nonshared schizophrenia and bipolar disorder alleles on cognition and educational attainment in the UK Biobank. Biological Society: Global Open Science 5 (6) 100601. (10.1016/j.bpsgos.2025.100601)
- Cameron, D. et al. 2024. Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia. Schizophrenia Bulletin Open 50 (5), pp.1171-1184. (10.1093/schbul/sbae083)
- Tume, C. E. et al. 2024. Genetic implication of specific glutamatergic neurons of the prefrontal cortex in the pathophysiology of schizophrenia. Biological Psychiatry 4 (5) 100345. (10.1016/j.bpsgos.2024.100345)
- Cameron, D. et al. 2023. Single nuclei RNA sequencing of 5 regions of the human prenatal brain implicates developing neuron populations in genetic risk for schizophrenia. Biological Psychiatry 93 , pp.157-166. (10.1016/j.biopsych.2022.06.033)
- Kouakou, M. et al., 2021. Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186 (6), pp.376-388. (10.1002/ajmg.b.32877)
- Cameron, D. et al. 2019. Transcriptional changes following cellular knockdown of the schizophrenia risk gene SETD1A are enriched for common variant association with the disorder. Molecular Neuropsychiatry 5 (2), pp.109-114. (10.1159/000497181)
- Pardinas, A. F. et al. 2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics 50 , pp.381-389. (10.1038/s41588-018-0059-2)
- Tansey, K. E. , Cameron, D. and Hill, M. J. 2018. Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks. Genome Medicine 10 14. (10.1186/s13073-018-0523-8)
- Clifton, N. et al. 2017. Hippocampal regulation of postsynaptic density Homer1 by associative learning. Neural Plasticity 2017 5959182. (10.1155/2017/5959182)
- Pardinas, A. et al. 2016. Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection. bioRxiv (10.1101/068593)
Thesis
- Cameron, D. 2019. Gene regulation in microglia and genetic risk for complex brain disorders. PhD Thesis , Cardiff University.
Biography
I am a bioinformatician and research software engineer specialising in the analysis of large-scale single-cell and functional genomics datasets. My research utilises modalities such as single-nucleus sequencing (snRNA-seq/snATAC-seq) and eQTL mapping alongside common and rare variant genetic data to identify the cell types and regulatory mechanisms implicated in neuropsychiatric disorders.
In addition to genomic research, I develop scalable and reproducible computational infrastructure for high-dimensional biological data. This involves building modular bioinformatics pipelines and software tools designed for deployment on high-performance computing (HPC) environments.
GitHub: link.
Supervisions
Current supervision
Yusuf Baran