![Duncan Cole](https://profiles-cardiff.imgix.net/attachments/2402?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Trosolwyg
I am a Clinical Reader in the Centre for Medical Education in the School of Medicine, and an Honorary Consultant in Medical Biochemistry and Metabolic Medicine. I am the Deputy Director for the MB BCh programme, with responsibilty for the curriculum. I have interests in curriculum development, clinical reasoning and clinical decision making, and in technology-enhanced learning. My work in these areas was recognised when I won the Rising Star award at the national BMA Cymru Wales Clinical Teacher of the Year awards in 2015.
My clinical interests are in adult inherited metabolic disease (IMD), where I am the clinical lead for the All Wales IMD service, and also in medical biochemistry, where I am consultant lead for several specialist services. The All Wales IMD service is nationally comissioned and cares for both children and adults. We provide services for people with lysosomal storage disease and are the only in centre in Wales that provides enzyme replacement therapy. We have recently been commissioned to develop our services for people with non-lysosomal storage disease, and to improve access to care for those in north Wales. Our unit is also a centre for the National Acute Porphyria Service, commissioned through NHS England. We host both clinical and laboratory services, including the Wales Newborn Screening Laboratory, and have a growing research base.
Cyhoeddiad
2018
- Lund, A. M. et al. 2018. Comprehensive long-term efficacy and safety of recombinant human alpha-mannosidase (velmanase alfa) treatment in patients with alpha-mannosidosis. Journal of Inherited Metabolic Disease 41(6), pp. 1225-1233. (10.1007/s10545-018-0175-2)
2017
- Cole, D., Rengasamy, E., Batchelor, S., Pope, C., Riley, S. and Cunningham, A. M. 2017. Using social media to support small group learning. BMC Medical Education 17(1), article number: 201. (10.1186/s12909-017-1060-7)
2007
- Sivasankar, B. et al. 2007. CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens. Molecular Immunology 44(11), pp. 2978-2987. (10.1016/j.molimm.2006.12.025)
2006
- Donev, R. M., Cole, D. S., Sivanaskar, B., Hughes, T. R. and Morgan, B. P. 2006. p53 regulates cellular resistance to complement lysis through enhanced expression of CD59 [RETRACTED]. Cancer Research 66(4), pp. 2451-8. (10.1158/0008-5472.CAN-05-3191)
2005
- Cole, D. S. 2005. Role of complement in neuronal cell turnover in the central nervous system. PhD Thesis, Cardiff University.
Articles
- Lund, A. M. et al. 2018. Comprehensive long-term efficacy and safety of recombinant human alpha-mannosidase (velmanase alfa) treatment in patients with alpha-mannosidosis. Journal of Inherited Metabolic Disease 41(6), pp. 1225-1233. (10.1007/s10545-018-0175-2)
- Cole, D., Rengasamy, E., Batchelor, S., Pope, C., Riley, S. and Cunningham, A. M. 2017. Using social media to support small group learning. BMC Medical Education 17(1), article number: 201. (10.1186/s12909-017-1060-7)
- Sivasankar, B. et al. 2007. CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens. Molecular Immunology 44(11), pp. 2978-2987. (10.1016/j.molimm.2006.12.025)
- Donev, R. M., Cole, D. S., Sivanaskar, B., Hughes, T. R. and Morgan, B. P. 2006. p53 regulates cellular resistance to complement lysis through enhanced expression of CD59 [RETRACTED]. Cancer Research 66(4), pp. 2451-8. (10.1158/0008-5472.CAN-05-3191)
Thesis
- Cole, D. S. 2005. Role of complement in neuronal cell turnover in the central nervous system. PhD Thesis, Cardiff University.
- Donev, R. M., Cole, D. S., Sivanaskar, B., Hughes, T. R. and Morgan, B. P. 2006. p53 regulates cellular resistance to complement lysis through enhanced expression of CD59 [RETRACTED]. Cancer Research 66(4), pp. 2451-8. (10.1158/0008-5472.CAN-05-3191)
Ymchwil
I started my research career in complement biology, working with Prof Paul Morgan, and with my senior appointment have developed my research interests in medical education and inherited metabolic disease. My current medical education projects are listed in the Teaching section, and are focussed on clinical reasoning and technology-enhanced learning. My interests in inherited metabolic disease focus on maintaining patient registries, and developing new tests for clinical use.
Medical education
I am interested in how medical students develop their ability to reason through a clinical problem, and make clinical decisions, during their journey through the medical course. I am particularly interested in how different courses and different educational interventions affect this, and how effectively we capture this in our assessments.
I have an interest in the use of internet-based curation tools such as Scoop.it, Storify and Diigo to support student learning. These tools allow staff and students to gather relevant resources freely available on the internet in one place, critically comment on them, and share them with others. We run projects evaluating their use and exploring how they can be integrated into teaching practice.
Inherited metabolic disease
We run patient registries as part of the Inherited Metabolic Disease service, and are looking to increase our participation going forwards. I also have collaborations with colleagues on the development of new tests for various inherited metabolic diseases.
Addysgu
I have a significant teaching role within the School of Medicine. I have designed and developed several components of the new "C21" medical undergraduate course. My current roles include:
- Applied Clinical Sciences module lead (Year 3)
- Hospital Front Door module lead (Year 3)
- Member of the Phase 2 working group
- Delivery metabolism teaching (Year 1)
- Development and delivery of medical biochemistry teaching (all years)
- Question writing (Single best answer MCQs)
- Examiner for year 2 and year 4 ISCEs
- Supervision of Student Selected Components (topic areas include medical education, inherited metabolic disease, and medical biochemistry)
I have interests in technology-enhanced learning and clinical reasoning, and am currently leading the following projects in this area:
- Acquisition of clinical reasoning skills by medical students in the new C21 curriculum: evaluation and assessment
- Supporting blended learning with digital curation tools (funded by Cardiff University's Centre for Education Innovation)
Bywgraffiad
I trained in medicine in Cardiff and South Wales, and obtained the MRCP in 2002, following which I undertook a PhD whilst on an MRC Clinical Training Fellowship with Professor Paul Morgan. I went on to train in Chemical Pathology and Metabolic Medicine, gaining the FRCPath in 2010 and sub-specialising in inherited metabolic disease. During this time I took an increasing role in teaching and curriculum development within the Department and medical school, and was appointed as a Clinical Senior Lecturer in 2011 on a teaching and scholarship track. In 2018 I was appointed Deputy Director of the undergraduate Medicine degree programme.