Overview
I am a Clinical Professor in the Centre for Medical Education in the School of Medicine and an Honorary Consultant in Metabolic Medicine. I am one of two Directors for the MB BCh programme, with responsibilty for curriculum and innovation. I have interests in curriculum development, clinical reasoning and clinical decision making, and in technology-enhanced learning. My work in these areas was recognised when I won the Rising Star award at the national BMA Cymru Wales Clinical Teacher of the Year awards in 2015.
My clinical interests are in adult inherited metabolic disease (IMD), where I am the clinical lead for the All Wales IMD service. The service is nationally comissioned and cares for both children and adults; I lead specifically for the adult services. We provide care for people with lysosomal storage disease and are the only in centre in Wales that provides enzyme replacement and related therapies. The service has expanded significantly under my leadership, and hosts teams based in south and north Wales, providing services across all IMDs. We have close links with the Cardiff Porphyria Service and the Newborn Screening and Metabolic laboratories, and have a growing research base with several collaborative projects.
Publication
2018
- Lund, A. M. et al. 2018. Comprehensive long-term efficacy and safety of recombinant human alpha-mannosidase (velmanase alfa) treatment in patients with alpha-mannosidosis. Journal of Inherited Metabolic Disease 41(6), pp. 1225-1233. (10.1007/s10545-018-0175-2)
2017
- Cole, D., Rengasamy, E., Batchelor, S., Pope, C., Riley, S. and Cunningham, A. M. 2017. Using social media to support small group learning. BMC Medical Education 17(1), article number: 201. (10.1186/s12909-017-1060-7)
2007
- Sivasankar, B. et al. 2007. CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens. Molecular Immunology 44(11), pp. 2978-2987. (10.1016/j.molimm.2006.12.025)
2006
- Donev, R. M., Cole, D. S., Sivanaskar, B., Hughes, T. R. and Morgan, B. P. 2006. p53 regulates cellular resistance to complement lysis through enhanced expression of CD59 [RETRACTED]. Cancer Research 66(4), pp. 2451-8. (10.1158/0008-5472.CAN-05-3191)
2005
- Cole, D. S. 2005. Role of complement in neuronal cell turnover in the central nervous system. PhD Thesis, Cardiff University.
Articles
- Lund, A. M. et al. 2018. Comprehensive long-term efficacy and safety of recombinant human alpha-mannosidase (velmanase alfa) treatment in patients with alpha-mannosidosis. Journal of Inherited Metabolic Disease 41(6), pp. 1225-1233. (10.1007/s10545-018-0175-2)
- Cole, D., Rengasamy, E., Batchelor, S., Pope, C., Riley, S. and Cunningham, A. M. 2017. Using social media to support small group learning. BMC Medical Education 17(1), article number: 201. (10.1186/s12909-017-1060-7)
- Sivasankar, B. et al. 2007. CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens. Molecular Immunology 44(11), pp. 2978-2987. (10.1016/j.molimm.2006.12.025)
- Donev, R. M., Cole, D. S., Sivanaskar, B., Hughes, T. R. and Morgan, B. P. 2006. p53 regulates cellular resistance to complement lysis through enhanced expression of CD59 [RETRACTED]. Cancer Research 66(4), pp. 2451-8. (10.1158/0008-5472.CAN-05-3191)
Thesis
- Cole, D. S. 2005. Role of complement in neuronal cell turnover in the central nervous system. PhD Thesis, Cardiff University.
- Donev, R. M., Cole, D. S., Sivanaskar, B., Hughes, T. R. and Morgan, B. P. 2006. p53 regulates cellular resistance to complement lysis through enhanced expression of CD59 [RETRACTED]. Cancer Research 66(4), pp. 2451-8. (10.1158/0008-5472.CAN-05-3191)
Research
I started my research career in complement biology, working with Prof Paul Morgan, and with my senior appointment have developed my research interests in medical education and inherited metabolic disease. My current medical education projects are listed in the Teaching section, and are focussed on clinical reasoning, the transition to clinical learning, and technology-enhanced learning. My interests in inherited metabolic disease focus on maintaining patient registries, and biomarker development.
Medical education
I am interested in how medical students develop their ability to reason through a clinical problem, and make clinical decisions, during their journey through the medical course,and how we can improve and train this skill. I am also interested in how students adapt to new ways of working and studying when they transition from the more structured phase 1 of the course to less structured learning in extended clinical placements. This is important, as if this can be improved, students will have a better experience, and will be enabled to make best use of the learning opportunities available to them.
I have developed an interest in the use of internet-based curation tools such as Scoop.it, Wakelet, and Diigo to support student learning. These tools allow staff and students to gather relevant resources freely available on the internet in one place, critically comment on them, and share them with others. We run projects evaluating their use and exploring how they can be integrated into teaching practice.
Inherited metabolic disease
We are currently running a project evaluating biomarkers in Fabry disease, which involves both laboratory and clinical studies. This is being lead jointly by myself and Prof Stuart Moat. We also participate in disease-specific patient registries, collaborate with colleagues in the School of Biosciences on projects involving other inherited metabolic diseases, and have an active programme of quality improvement. We have now also opened an Inherited Metabolic Disease Biobank.
Teaching
I am Co-Director of the MBBCh programme in the School of Medicine. I have designed and developed several components of the "C21" medical undergraduate course and am now leading a further Curriculum and Assessment review. My current roles include:
- Lead for the MBBCh Curriculum, Assessment and Admissions review
- Lead for curriculum in the undergraduate Medicine programme
- Applied Clinical Sciences module lead (Year 3)
- Delivery metabolism teaching (Year 1)
- Development and delivery of medical biochemistry teaching (all years)
- Question writing (Single best answer MCQs)
- Examiner for year 2 and year 4 ISCEs
- Supervision of Student Selected Components (topic areas include medical education, inherited metabolic disease, and medical biochemistry)
- Delivery, planning and assessment on the intercalated BSc module on Biomarkers
I am also currently leading on a project to improve the transition to clinical learning between years 2 and 3 of the MBBCh.
I have interests in technology-enhanced learning and clinical reasoning, and have led the following projects in this area:
- Acquisition of clinical reasoning skills by medical students in the new C21 curriculum: evaluation and assessment
- Supporting blended learning with digital curation tools (funded by Cardiff University's Centre for Education Innovation)
Biography
I trained in medicine in Cardiff and South Wales, and obtained the MRCP in 2002, following which I undertook a PhD whilst on an MRC Clinical Training Fellowship with Professor Paul Morgan. I went on to train in Chemical Pathology and Metabolic Medicine, gaining the FRCPath in 2010 and sub-specialising in inherited metabolic disease. During this time I took an increasing role in teaching and curriculum development within the Department and School of Medicine, and was appointed as a Clinical Senior Lecturer in 2011 on a teaching and scholarship track. In 2018 I was appointed Deputy Director of the undergraduate Medicine degree programme. In 2020 I was promoted to Clinical Reader, and in 2024 was appointed as Co-Director of the MBBCh and promoted to Clinical Professor.
Contact Details
Specialisms
- Curriculum and pedagogy
- Clinical reasoning
- Technology-enhanced learning
- Inherited metabolic disease