Ewch i’r prif gynnwys
Peter Collins

Yr Athro Peter Collins

Professor of Haematology

Yr Ysgol Meddygaeth

Trosolwyg

Mae fy ymchwil yn canolbwyntio ar ddiagnosis a thriniaeth anhwylderau gwaedu etifeddol a chaffaeledig. Mae'r gwaith yn rhychwantu astudiaethau clinigol a gwyddoniaeth sylfaenol ac rwy'n cydweithio â nifer o grwpiau yng Nghaerdydd ac ar draws y byd.

Mae fy ngwaith clinigol wedi'i leoli yng Nghanolfan Haemoffilia Caerdydd ac mae'n cynnwys trin pobl ag anhwylderau etifeddol a chaffael haemostasis a thrombosis.

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Ymchwil

Research overview

My research interests focus on blood clotting. This includes studies into the diagnosis and treatment of inherited and acquired bleeding and laboratory studies into understanding of mechanisms of how blood clots.

Research description

Mechanisms of coagulation

I work in a group of basic scientists and clinicians jointly led with Professor O’Donnell that is investigating mechanisms of blood coagulation. Projects include the role of oxidised phospholipids in supporting blood clotting reactions, mechanisms underlying the antiphospholipid syndrome, the effects of oxidised phospholipids in cardiovascular disease and how phospholipids support tissue factor function. This work is support by project and program grants from Wellcome and The British Heart Foundation and a clinical training fellowship from BHF.

In related studies Dr Meike Heurich is investigating the interaction and crosstalk between the complement system and coagulation supported by a NISCHR fellowship. The work is studying how two important innate defense mechanisms interact during normal physiology and disease processes.

Clinical studies

Bleeding at the time of childbirth

I collaborate with colleagues in obstetric and anaesthesia investigating mechanisms and treatment of bleeding at the time of childbirth. A number of our studies have been completed, for example OBS1 (obstetric bleeding study 1) and suggest an important role for the blood clotting factor fibrinogen in controlling bleeding. These studies have led on to our group being awarded funding for a multicentre, randomised, blinded study of fibrinogen versus placebo in the management of postpartum haemorrhage (OBS2). This work is being done in collaboration with Professor Judith Hall as part of the Critical Illness Research Group at Cardiff University and is very well supported by the South East Wales Trials Unit.

Acquired haemophilia A

I have a longstanding interest in the auto-immune disease acquired haemophilia A which presents with sudden onset of severe bleeding. It is caused by the development of an inhibitory antibody to coagulation factor VIII. Along with colleagues in a Europe-wide collaboration the cause and treatment of this disorder is being investigated through the European Acquired Haemophilia Registry (EACH2).

Factor VIII pharmacokinetics (PK) and the treatment of haemophilia A

I work with an international collaborative group investigating the role of factor VIII PK in the management of haemophilia, especially in the context of prophylaxis. A clinical trial is underway to evaluate the role of PK in patient management. The work is being extended to the measurement of factor VIII PK in the context of factor VIII inhibitors.

A further project with Dr Derrick Bowen is investigating mechanisms that predispose patients with severe haemophilia A to haemophilic arthropathy.

Bruising in children with and without inherited bleeding disorders

In collaboration with the Department of Child Health (Professor Alison Kemp and Dr Sabine Maguire) and paediatric haematologists in Edinburgh, Glasgow, Great Ormond Street, Newcastle and Toronto I am investigating the pattern of bruising in children with and without inherited bleeding disorders and comparing this to children who have suffered physical abuse. The work aims to improve the diagnosis of physical abuse and reduced the chance of misdiagnosis of bleeding disorders.

Clinical trials

The haemophilia centre in Cardiff is an active site for clinical trials in the field of inherited bleeding disorders.

Addysgu

Rwy'n addysgu myfyrwyr meddygol a deintyddol am anhwylderau thrombosis a haemostasis trwy raglen o ddarlithoedd.

Bywgraffiad

Cymwysterau:

BA Anrh Cantab, MBBS, MD (Lond), FRCP, FRCpath