Professor Peter Collins

Professor of Haematology

: CollinsPW@cardiff.ac.uk
: +44 29207 48365

My research focuses on the diagnosis and treatment of inherited and acquired bleeding disorders. The work spans both clinical studies and basic science and I collaborate with a number of groups at Cardiff and across the world.

My clinical work is based in the Cardiff Haemophilia Centre and involves treating people with inherited and acquired disorders of haemostasis and thrombosis.

Date
Type

2002

Clark, S. R., Coffey, M. J., McLean, R. M., Collins, P. W., Lewis, M. J., Cross, A. R. and O'Donnell, V. B. 2002. Characterization of nitric oxide consumption pathways by normal, chronic granulomatous disease and myeloperoxidase-deficient human neutrophils. The Journal of Immunology 169(10), pp. 5889-5896.
Brown, S. A., Bowen, D. J., Hallett, M. B., Giddings, J. C. and Collins, P. W. 2002. Factor VIIa induced release of von Willebrand factor from human umbilical vein endothelial cells by a tyrosine kinase dependent pathway. Journal of Thrombosis and Haemostasis 87, pp. 1057-1061.
Brown, S. A., Collins, P. W. and Bowen, D. J. 2002. Heterogeneous detection of A-antigen on von Willebrand factor derived from platelets, endothelial cells and plasma. Thrombosis and Haemostasis 87(6), pp. 990-996.
De Brasi, C. D., Bowen, D. J., Collins, P. W. and Larripa, I. B. 2002. The CpG island in intron 22 of the factor VIII gene is predominantly methylated on the X chromosome of human males. Journal of Human Genetics 47(5), pp. 239-242. (10.1007/s100380200032)
De Brasi, C. D., Bowen, D. J., Collins, P. W. and Larripa, I. B. 2002. The CpG island in intron 22 of the factor VIII gene is predominantly methylated on the X chromosome of human males. Journal of Human Genetics 47(5), pp. 239-242.

2001

Bowen, D. J., MacLean, R. M., Pellard, S. and Collins, P. W. 2001. High concentrations of coagulation factor VIII and thrombosis: Is the factor VIII-binding domain of von Willebrand factor implicated?. British Journal of Haematology 113(3), pp. 655-657. (10.1046/j.1365-2141.2001.02830.x)

2000

Mumford, A. D. et al. 2000. A23187 induced apoptosis and pro-coagulant activity are delayed, but not absent, in lymphocytes from an individual with Scott syndrome. Blood 96(11), pp. 254A-254A.
Rhys-Dillon, C., Massey, E. J., Loran, C., Dasani, H., Collins, P. W. and Williams, B. D. 2000. Clinical symptoms and signs do not predict the presence of mixed cryoglobulinaemia in patients with chronic hepatitis C virus infection when compared with age and sex matched controls. Blood 96(11), pp. 87B-87B.
Williams, J., Dasani, H., Massey, E. J., Hutchings, A., Buss, D. and Collins, P. W. 2000. The topical non steroidal anti-inflammatory drug [NSAID] piroxicam gel has no significant effect on primary platelet related haemostasis in healthy volunteers. Blood 96(11), pp. 70B-71B.
Bowen, D. J., De Brasi, C. D., Larripa, I. B. and Collins, P. W. 2000. A new polymorphism in the human factor VIII gene: implications for linkage analysis in haemophilia A and for the evolution of int22h sequences. British Journal of Haematology 111(2), pp. 544-548. (10.1111/j.1365-2141.2000.02373.x)

1999

De Brasi, C. D., Bowen, D. J., Collins, P. W. and Larripa, I. B. 1999. Specific analysis of the intron 22 XbaI polymorphism of the human factor VIII gene using long-distance PCR. British Journal of Haematology 107(3), pp. 566-568. (10.1046/j.1365-2141.1999.01731.x)
Lee, C. A. et al. 1999. Pharmacokinetics of recombinant factor VIII (recombinate) using one-stage clotting and chromogenic factor VIII assay. Thrombosis and Haemostasis 82(6), pp. 1644-1647.
MacLean, R. M., Feeney, G. P., Bowley, S. J., Bowen, D. J., Worwood, M. and Collins, P. W. 1999. Factor V Leiden and the common haemochromatosis mutation HFE C282Y: is there an association in familial venous thromboembolic disease?. British Journal of Haematology 107(1), pp. 210-212. (10.1046/j.1365-2141.1999.01663.x)
Giddings, J. C., Phillips, S. A. and Collins, P. W. 1999. Recovery of P-selectin and ICAM-1 expression in passaged cultured human endothelial cells under conditions of flow. Thrombosis and Haemostasis, pp. 807-807.
Phillips, S. A., Giddings, J. C., Maclean, R. and Collins, P. W. 1999. Impaired P-selectin expression associated with defective platelet phospholipid redistribution in a patient with Scott Syndrome. Thrombosis and Haemostasis, pp. 796-797.
Maclean, R. M., Phillips, S. A., Brown, S. A., Berryman, K. M., Giddings, J. C. and Collins, P. W. 1999. Markers of platelet activation following DDAVP infusion. Thrombosis and Haemostasis, pp. 166-166.
Maclean, R. M., Phillips, S. A., Brown, S. A., Berryman, K. A., Giddings, J. C. and Collins, P. W. 1999. Markers of platelet activation following DDAVP infusion in patients with mild haemophilia A and type 1 von Willebrand disease. British Journal of Haematology 105, pp. 47-47.
Hazell, C., Burr, M., Collins, P. W. and Karani, G. 1999. Investigation of the possible link between exposure to air pollution and changes in blood coagulation parameters. Environment International 25(1), pp. 9-16. (10.1016/S0160-4120(98)00091-9)

1998

Clark, Z. E., Bowen, D. J., Whatley, S. D., Bellamy, M. F., Collins, P. W. and McDowell, I. F. 1998. Genotyping method for methylenetetrahydrofolate reductase (C677T thermolabile variant) using heteroduplex technology [Technical Brief]. Clinical Chemistry 44(11), pp. 2360-2362.
Routledge, P. A., Shetty, H. G. M., White, J. P. and Collins, P. W. 1998. Case studies in therapeutics: warfarin resistance and inefficacy in a man with recurrent thromboembolism, and anticoagulant-associated priapism [Case report]. British Journal of Clinical Pharmacology 46(4), pp. 343-346. (10.1046/j.1365-2125.1998.t01-1-00796.x)
Bowen, D. J., Bowley, S., John, M. and Collins, P. W. 1998. Factor V Leiden (G1691A), the Prothrombin 3’-Untranslated Region Variant (G20210A) and Thermolabile Methylenetetra-hydrofolate Reductase (C677T): A Single Genetic Test Genotypes all Three Loci – Determination of Frequencies in the S. Wales Population. Thrombosis and Haemostasis 79(5), pp. 949-954.
Rye, A. D., Lees, S. J., Powell, A. L. and Collins, P. W. 1998. Clinical evaluation of oral anticoagulant monitoring with the TAS near patient test system. British Journal of Haematology 101, pp. 56-56.

1996

Noble, K. E., Panayiotidis, P., Collins, P. W., Hoffbrand, A. V. and Yong, K. L. 1996. Monocytes induce E-selectin gene expression in endothelial cells: role of CD11/CD18 and extracellular matrix proteins. European Journal of Immunology 26(12), pp. 2944-2951. (10.1002/eji.1830261221)
Jenkins, P. V., Ononye, C., Collins, P. W. and Pasi, K. J. 1996. Dominant type 1 vonWillebrand's disease as a result of a deletion of a single codon in exon 28 of the VWF gene [Abstract]. British Journal of Haematology 93(S2), article number: 1176.
Hopster, D. J., Dodd, S., Nott, C., Collins, P. W., Newland, A. C. and van der Walt, J. D. 1996. Renal pathology in haematological malignancies: An autopsy study [Synopsis]. The Journal of Pathology 179(s1), pp. A32-A32. (10.1002/path.1996.1711790502)

1995

Jenkins, P. V., Ononye, C., Collins, P. W. and Pasi, K. J. 1995. Dominant type 1 von Willebrands disease as a result of a four base pair deletion in exon 28 of the von Willebrand factor gene. Blood 86(10), pp. 265-265.
Collins, P. W., Goldman, E., Lilley, P., Pasi, K. J. and Lee, C. A. 1995. Clinical experience of factor XI deficiency: the role of fresh frozen plasma and factor XI concentrate. Haemophilia 1(4), pp. 227-231. (10.1111/j.1365-2516.1995.tb00080.x)
Collins, P. W., Lilley, P., Goldman, E., Pasi, K. J. and Lee, C. A. 1995. Clinical-experience of factor-XI deficiency - the use of fresh-frozen plasma and factor-XI concentrate. Thrombosis and Haemostasis 73(6), pp. 1442-1442.
Collins, P. W., Fields, P., Goldman, E., Lee, C. A. and Pasi, K. J. 1995. The use of RFVIIA to treat a factor-IX inhibitor following anaphylaxis with factor-IX concentrate. Thrombosis and Haemostasis 73(6), pp. 1029-1029.

1994

Collins, P. W., Reittie, J. E., Hoffbrand, A. V., Pasi, K. J. and Yong, K. L. 1994. Enhanced tissue factor expression due to monocyte - endothelial-cell interaction - modulation by interferon-gamma and the role of ICAM-1. Blood 84(10), pp. A189-A189.
Yong, K. L., Reittie, J. E., Collins, P. W. and Hoffbrand, A. V. 1994. Granulocyte-colony-stimulating factor increases neutrophil migration across endothelium without an effect on adhesion - role of PECAM-1. Blood 84(10), pp. A32-A32.

1993

Razak, K., Collins, P. W., Kelsey, S. M. and Newland, A. C. 1993. Binding of antibodies to different cd13 epitopes on human myeloid leukemic-cells. International Journal of Oncology 3(4), pp. 749-754. (10.3892/ijo.3.4.749)
Side, L., Razak, K., Collins, P. W., Gutteridge, C. N., Kelsey, S. M., Syndercombe-Court, Y. D. and Newland, A. C. 1993. Prognostic value of CD13 CD33 ratio for AML patient survival and the significance of induction of CD13 on AML cells [Abstract]. British Journal of Haematology 84(s1), pp. 2-2. (10.1111/j.1365-2141.1993.tb06831.x)
Collins, P. W. and Newland, A. C. 1993. Inhibition of VWF release from endothelial-cells by hydroxyethyl starches - a possible cause of acquired vonwillebrand disease [Abstract]. British Journal of Haematology 84(s1), pp. 16-16. (10.1111/j.1365-2141.1993.tb06831.x)
Jiang, X. R., Collins, P. W., Macey, M. G. and Newland, A. C. 1993. Circumvention of P-glycoprotein-mediated multidrug-resistance of human leukemia by a nonimmunosuppressive cyclosporine, SDZ PSC-833 [Abstract]. British Journal of Haematology 84(s1), pp. 30-30. (10.1111/j.1365-2141.1993.tb06831.x)
Collins, P. W., Roderick, A., O'Brien, D., Tuddenham, E., Goldstone, A. and Newland, A. C. 1993. Bone-marrow transplantation is not associated with increased levels of factor-VIIa [Abstract]. British Journal of Haematology 84(s1), pp. 53-53. (10.1111/j.1365-2141.1993.tb06831.x)

1992

Kelsey, S. M., Weinhardt, B., Collins, P. W. and Newland, A. C. 1992. Teicoplanin plus ciprofloxacin versus gentamicin plus piperacillin in the treatment of febrile neutropenic patients [Erratum]. European Journal of Clinical Microbiology and Infectious Diseases 11(10), pp. 960-960. (10.1007/BF01962389)

1991

Collins, P. W., Slocombe, G., Wainwright, A. and Newland, A. C. 1991. A pilot study using intravenous immunoglobulin for the prevention of infection during remission induction in acute leukaemia. Leukemia and Lymphoma 6(1), pp. 25-29.

1990

Collins, P. W., De Lord, C. and Newland, A. C. 1990. Pancoast's tumour due to aspergilloma [Letter]. The Lancet 336(8730), pp. 1595-1595. (10.1016/0140-6736(90)93385-3)
Collins, P. W., Kelsey, S. M., De Lord, C. and Newland, A. C. 1990. Invasive aspergillosis in immunosuppressed patients [Letter]. British Medical Journal 301(6759), pp. 1046-1046. (10.1136/bmj.301.6759.1046-c)

Research overview

My research interests focus on blood clotting. This includes studies into the diagnosis and treatment of inherited and acquired bleeding and laboratory studies into understanding of mechanisms of how blood clots.

Research description

Mechanisms of coagulation

I work in a group of basic scientists and clinicians jointly led with Professor O’Donnell that is investigating mechanisms of blood coagulation. Projects include the role of oxidised phospholipids in supporting blood clotting reactions, mechanisms underlying the antiphospholipid syndrome, the effects of oxidised phospholipids in cardiovascular disease and how phospholipids support tissue factor function. This work is support by project and program grants from Wellcome and The British Heart Foundation and a clinical training fellowship from BHF.

In related studies Dr Meike Heurich is investigating the interaction and crosstalk between the complement system and coagulation supported by a NISCHR fellowship. The work is studying how two important innate defence mechanisms interact during normal physiology and disease processes.

Clinical studies

Bleeding at the time of childbirth

I collaborate with colleagues in obstetric and anaesthesia investigating mechanisms and treatment of bleeding at the time of childbirth. A number of our studies have been completed, for example OBS1 (obstetric bleeding study 1) and suggest an important role for the blood clotting factor fibrinogen in controlling bleeding. These studies have led on to our group being awarded funding for a multicentre, randomised, blinded study of fibrinogen versus placebo in the management of postpartum haemorrhage (OBS2). This work is being done in collaboration with Professor Judith Hall as part of the Critical Illness Research Group at Cardiff University and is very well supported by the South East Wales Trials Unit.

Acquired haemophilia A

I have a longstanding interest in the auto-immune disease acquired haemophilia A which presents with sudden onset of severe bleeding. It is caused by the development of an inhibitory antibody to coagulation factor VIII. Along with colleagues in a Europe-wide collaboration the cause and treatment of this disorder is being investigated through the European Acquired Haemophilia Registry (EACH2).

Factor VIII pharmacokinetics (PK) and the treatment of haemophilia A

I work with an international collaborative group investigating the role of factor VIII PK in the management of haemophilia, especially in the context of prophylaxis. A clinical trial is underway to evaluate the role of PK in patient management. The work is being extended to the measurement of factor VIII PK in the context of factor VIII inhibitors.

A further project with Dr Derrick Bowen is investigating mechanisms that predispose patients with severe haemophilia A to haemophilic arthropathy.

Bruising in children with and without inherited bleeding disorders

In collaboration with the Department of Child Health (Professor Alison Kemp and Dr Sabine Maguire) and paediatric haematologists in Edinburgh, Glasgow, Great Ormond Street, Newcastle and Toronto I am investigating the pattern of bruising in children with and without inherited bleeding disorders and comparing this to children who have suffered physical abuse. The work aims to improve the diagnosis of physical abuse and reduced the chance of misdiagnosis of bleeding disorders.

Clinical trials

The haemophilia centre in Cardiff is an active site for clinical trials in the field of inherited bleeding disorders.

I teach medical and dental students about disorders of thrombosis and haemostasis through a programme of lectures.

Qualifications:

BA Hons Cantab, MBBS, MD (Lond), FRCP, FRCpath

New family of lipids plays key role in clot formation

28 November 2017

Professor Peter Collins

Overview

Publication

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