Yr Athro Vincenzo Crunelli
Athro
Ysgol y Biowyddorau
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
My research focuses on the cellular and network mechanisms operating in the thalamus and cortex during sleep and absence epilepsy, focussing on both neuronal and astrocytic assemblies. My multi-disciplinary group uses a combination of electrophysiological, morphological, immunocytochemical, computational and 2-photon laser scanning microscopical techniques both in normal animals and transgenic models. These techniques are applied to in vitro (primary culture, brain slices), as well as in anaesthetized and freely behaving preparations. We also use MRI spectroscopy to measure neurotransmitters and their metabolites in the brain of children and teenagers with absence epilepsy.
I am affiliate with:
Neuroscience and Mental Health Research Institute (https://www.cardiff.ac.uk/neuroscience-mental-health)
Cardiff Sleep Network (https://www.cardiff.ac.uk/research/explore/research-units/cardiff-sleep-network)
Interested in joining my lab as a self-funded post-graduate student or a postdoc/fellow? Please contact me by email.
Cyhoeddiad
2024
- Dervinis, M. and Crunelli, V. 2024. Sleep waves in a large‐scale corticothalamic model constrained by activities intrinsic to neocortical networks and single thalamic neurons. CNS Neuroscience and Therapeutics 30(3), article number: e14206. (10.1111/cns.14206)
- Casarrubea, M. et al. 2024. A quantitative and T‐pattern analysis of anxiety‐like behavior in male GAERS, NEC, and Wistar rats bred under the same conditions, against a commercially available Wistar control group in the hole board and elevated plus maze tests. CNS Neuroscience and Therapeutics 30(3), article number: e14443. (10.1111/cns.14443)
2023
- Neuparth-Sottomayor, M. et al. 2023. Cognitive comorbidities of experimental absence seizures are independent of anxiety. Neurobiology of Disease 186, article number: 106275. (10.1016/j.nbd.2023.106275)
- Dervinis, M. and Crunelli, V. 2023. Spike-and-wave discharges of absence seizures in a sleep waves-constrained corticothalamic model. CNS Neuroscience & Therapeutics 30(3), article number: e14204. (10.1111/cns.14204)
- Atherton, Z. et al. 2023. Higher-order thalamic nuclei facilitate the generalization and maintenance of spike-and-wave discharges of absence seizures. Neurobiology of Disease 178, article number: 106025. (10.1016/j.nbd.2023.106025)
- Crunelli, V., David, F., Morais, T. P. and Lorincz, M. L. 2023. HCN channels and absence seizures. Neurobiology of Disease 181, article number: 106107. (10.1016/j.nbd.2023.106107)
- McCafferty, C. et al. 2023. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 14(1) (10.1038/s41467-022-35535-4)
2022
- Roebber, J. K., Lewis, P. A., Crunelli, V., Navarrete, M. and Hamandi, K. 2022. Effects of anti-seizure medication on sleep spindles and slow waves in drug-resistant epilepsy. Brain Sciences 12(10), article number: 1288. (10.3390/brainsci12101288)
- Cassar, D., Radic, M., Casarrubea, M., Crunelli, V. and Di Giovanni, G. 2022. The effect of cannabinoid receptor agonist WIN 55,212–2 on anxiety-like behavior and locomotion in a genetic model of absence seizures in the elevated plus-maze. CNS Neuroscience and Therapeutics 28(8), pp. 1268-1270. (10.1111/cns.13848)
- De Deurwaerdère, P. et al. 2022. Cannabinoid 1/2 receptor activation induces strain-dependent behavioral and neurochemical changes in genetic absence epilepsy rats from Strasbourg and non-epileptic control rats. Frontiers in Cellular Neuroscience 16, article number: 886033. (10.3389/fncel.2022.886033)
2021
- Deidda, G., Pierucci, M., Crunelli, V. and Di Giovanni, G. 2021. 5-HT/GABA interaction in neurodevelopment and plasticity. In: Progress in Brain Research., Vol. 259. ELSEVIER SCIENCE BV, pp. 287-317., (10.1016/bs.pbr.2021.01.009)
- Iacone, Y. et al. 2021. Systemic administration of ivabradine, a hyperpolarization-activated cyclic nucleotide-gated channel inhibitor, blocks spontaneous absence seizures. Epilepsia 62(7), pp. 1729-1743. (10.1111/epi.16926)
- Deidda, G., Crunelli, V. and Di Giovanni, G. 2021. 5-HT/GABA interaction in epilepsy. In: Progress in Brain Research., Vol. 259. ELSEVIER, pp. 265-286., (10.1016/bs.pbr.2021.01.008)
2020
- Crunelli, V., Lorincz, M. L., McCafferty, C., Regis, L. C., Leresche, N., Di Giovanni, G. and David, F. 2020. Clinical and experimental insight in pathophysiology, comorbidity and therapy of absence seizures. Brain 143(8), pp. 2341-2368. (10.1093/brain/awaa072)
- Davis, B., David, F., O’Regan, C., Adam, M., Harwood, A., Crunelli, V. and Isles, A. 2020. Impairments in sensory-motor gating and information processing in a mouse model of Ehmt1 haploinsufficiency. Brain and Neuroscience Advances 4 (10.1177/2398212820928647)
- Armada-Moreira, A. et al. 2020. Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases. Frontiers in Cellular Neuroscience 14, article number: 90. (10.3389/fncel.2020.00090)
- Xapelli, S., Diógenes, M. J., Crunelli, V., Fitzsimons, C. P. and Vaz, S. H. 2020. Editorial: glial and neural stem cells as new therapeutic targets for neurodegenerative disorders. Frontiers in Cellular Neuroscience 14, article number: 71. (10.3389/fncel.2020.00071)
2019
- Corney, B., Widnall, C., Rees, D., Davies, J., Crunelli, V. and Carter, D. 2019. Regulatory architecture of the neuronal Cacng2/Tarpγ2 gene promoter: multiple repressive domains, a polymorphic regulatory short tandem repeat, and bidirectional organization with co-regulated lncRNAs. Journal of Molecular Neuroscience 67(2), pp. 282-294. (10.1007/s12031-018-1208-x)
2018
- Baruchin, L. J., Ranson, A., Good, M. and Crunelli, V. 2018. Absence of neuronal response modulation with familiarity in perirhinal cortex. Neuroscience 394, pp. 23-29. (10.1016/j.neuroscience.2018.10.020)
- McCafferty, C., Connelly, W. M., Celli, R., Ngomba, R. T., Nicoletti, F. and Crunelli, V. 2018. Genetic rescue of absence seizures. CNS Neuroscience & Therapeutics 24(8), pp. 745-758. (10.1111/cns.12858)
- David, F. et al. 2018. Suppression of HCN channel function in thalamocortical neurons prevents genetically determined and pharmacologically induced absence seizures. Journal of Neuroscience 38(30), pp. 6615-6627. (10.1523/JNEUROSCI.0896-17.2018)
- Di Giovanni, G., Crunelli, V. and Rizzolatti, G. 2018. Editorial: Interdisciplinary approaches for neuropathology. CNS Neuroscience & Therapeutics 24(8), pp. 665-668. (10.1111/cns.13004)
- Bombardi, C., Venzi, M., Crunelli, V. and Di Giovanni, G. 2018. Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model. Neuropharmacology 136(Part A), pp. 56-67. (10.1016/j.neuropharm.2018.01.047)
- McCafferty, C. et al. 2018. Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures. Nature Neuroscience 21, pp. 744-756. (10.1038/s41593-018-0130-4)
- Crunelli, V. et al. 2018. Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity. Nature Reviews Neuroscience 19, pp. 107-118. (10.1038/nrn.2017.151)
2017
- Connelly, W. M., Crunelli, V. and Errington, A. C. 2017. Variable action potential backpropagation during tonic firing and low-threshold spike bursts in thalamocortical but not thalamic reticular nucleus neurons. Journal of Neuroscience 37(21), pp. 5319-5333. (10.1523/JNEUROSCI.0015-17.2017)
2016
- Guo, J. N. et al. 2016. Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. Lancet Neurology 15(13), pp. 1336-1345. (10.1016/S1474-4422(16)30295-2)
- Venzi, M., David, F., Bellet, J., Cavaccini, A., Bombardi, C., Crunelli, V. and Di Giovanni, G. 2016. Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures. Neuropharmacology 108, pp. 292-304. (10.1016/j.neuropharm.2016.04.016)
- Connelly, W. M., Crunelli, V. and Errington, A. C. 2016. Passive synaptic normalization and input synchrony-dependent amplification of cortical feedback in thalamocortical neuron dendrites. Journal of Neuroscience 36(13), pp. 3735-3754. (10.1523/JNEUROSCI.3836-15.2016)
- David, F., Crunelli, V., Leresche, N. and Lambert, R. C. 2016. Dynamic Analysis of the Conditional Oscillator Underlying Slow Waves in Thalamocortical Neurons. Frontiers in Neural Circuits 10, pp. 1-11., article number: 10. (10.3389/fncir.2016.00010)
- Avoli, M., Crunelli, V. and Jefferys, J. 2016. Preface for methods and models in epilepsy research. Journal of Neuroscience Methods 260, pp. 1. (10.1016/j.jneumeth.2015.11.016)
- Lidster, K. et al. 2016. Opportunities for improving animal welfare in rodent models of epilepsy and seizures. Journal of Neuroscience Methods 260, pp. 2-25. (10.1016/j.jneumeth.2015.09.007)
- Connelly, W., Laing, M., Errington, A. C. and Crunelli, V. 2016. The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level. Frontiers in Neural Circuits 9, article number: 89. (10.3389/fncir.2015.00089)
2015
- Crunelli, V. and Di Giovanni, G. 2015. Differential control by 5-HT and 5-HT1A, 2A, 2C receptors of phasic and tonic GABAA inhibition in the visual thalamus [Letter]. CNS Neuroscience & Therapeutics 21(12), pp. 967-970. (10.1111/cns.12480)
- Connelly, W. M., Crunelli, V. and Errington, A. C. 2015. The global spike: conserved dendritic properties enable unique Ca2+ spike generation in low-threshold spiking neurons. Journal of Neuroscience 35(47), pp. 15505-15522. (10.1523/JNEUROSCI.2740-15.2015)
- Griemsmann, S. et al. 2015. Characterization of panglial gap junction networks in the thalamus, neocortex, and hippocampus reveals a unique population of glial cells. Cerebral Cortex 25(10), pp. 3420-3433. (10.1093/cercor/bhu157)
- Lorincz, M. L., Gunner, D., Bao, Y., Connelly, W. M., Isaac, J. T. R., Hughes, S. W. and Crunelli, V. 2015. A distinct class of slow (~0.2–2 Hz)) intrinsically bursting layer 5 pyramidal neurons determines UP/DOWN state dynamics in the neocortex. Journal of Neuroscience 35(14), pp. 5442-5458. (10.1523/JNEUROSCI.3603-14.2015)
- Crunelli, V., David, F., Lorincz, M. L. and Hughes, S. W. 2015. The thalamocortical network as a single slow wave-generating unit. Current Opinion in Neurobiology 31, pp. 72-80. (10.1016/j.conb.2014.09.001)
- Venzi, M., Di Giovanni, G. and Crunelli, V. 2015. A critical evaluation of the Gamma-Hydroxybutyrate (GHB) model of absence seizures. CNS Neuroscience & Therapeutics 21(2), pp. 123-140. (10.1111/cns.12337)
- Crunelli, V., Carmignoto, G. and Steinhauser, C. 2015. Novel astrocyte targets: New avenues for the therapeutic treatment of epilepsy. The Neuroscientist 21(1), pp. 62-83. (10.1177/1073858414523320)
2014
- Gould, T. M., Chen, L., Emri, Z., Pirttimaki, T., Errington, A. C., Crunelli, V. and Parri, H. R. 2014. GABAB receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 369(1654), article number: 20130607. (10.1098/rstb.2013.0607)
- Taylor, H. L. et al. 2014. Investigating local and long-range neuronal network dynamics by simultaneous optogenetics, reverse microdialysis and silicon probe recordings in vivo. Journal of Neuroscience Methods 235, pp. 83-91. (10.1016/j.jneumeth.2014.06.031)
- Crunelli, V., David, F., Leresche, N. and Lambert, R. C. 2014. Role for T-type Ca2+ channels in sleep waves. Pflugers Archiv European Journal of Physiology 466(4), pp. 735-745. (10.1007/s00424-014-1477-3)
- Crunelli, V. and Di Giovanni, G. 2014. Monoamine modulation of tonic GABAA inhibition. Reviews in the Neurosciences 25(2), pp. 195-206. (10.1515/revneuro-2013-0059)
2013
- David, F. et al. 2013. Essential thalamic contribution to slow waves of natural sleep. Journal of Neuroscience 33(50), article number: 19599. (10.1523/JNEUROSCI.3169-13.2013)
- Connelly, W. M., Errington, A. C. and Crunelli, V. 2013. γ-Hydroxybutyric Acid (GHB) is not an agonist of extrasynaptic GABAA receptors. PLoS ONE 8(11), article number: e79062. (10.1371/journal.pone.0079062)
- Connelly, W. M., Errington, A. C., Giovanni, G. D. and Crunelli, V. 2013. Metabotropic regulation of extrasynaptic GABAA receptors. Frontiers in Neural Circuits 7, article number: 171. (10.3389/fncir.2013.00171)
- Yagüe, J. G., Cavaccini, A., Errington, A. C., Crunelli, V. and Di Giovanni, G. 2013. Dopaminergic modulation of tonic but not phasic GABAA-receptor-mediated current in the ventrobasal thalamus of Wistar and GAERS rats. Experimental Neurology 247, pp. 1-7. (10.1016/j.expneurol.2013.03.023)
- Pirttimaki, T., Parri, H. R. and Crunelli, V. 2013. Astrocytic GABA transporter GAT-1 dysfunction in experimental absence seizures. The Journal of Physiology 591(4), pp. 823-833. (10.1113/jphysiol.2012.242016)
- Lambert, R. C., Bessaïh, T., Crunelli, V. and Leresche, N. 2013. The many faces of T-type calcium channels. Pflugers Archiv European Journal of Physiology 466(3), pp. 415-423. (10.1007/s00424-013-1353-6)
- Wade, J., McDaid, L., Harkin, J., Crunelli, V. and Kelso, S. 2013. Biophysically based computational models of astrocyte ~ neuron coupling and their functional significance. Frontiers in Computational Neuroscience 7, article number: 44. (10.3389/fncom.2013.00044)
- Connelly, W. M., Fyson, S. J., Errington, A. C., McCafferty, C. P., Cope, D. W., Di Giovanni, G. and Crunelli, V. 2013. GABAB receptors regulate extrasynaptic GABAa receptors. Journal of Neuroscience 33(9), pp. 3780-3785. (10.1523/JNEUROSCI.4989-12.2013)
- Crunelli, V. and Carmignoto, G. 2013. New vistas on astroglia in convulsive and non-convulsive epilepsy highlight novel astrocytic targets for treatment. The Journal of Physiology 591(4), pp. 775-785. (10.1113/jphysiol.2012.243378)
- Hughes, S. and Crunelli, V. 2013. UP states rise from the depths. Nature Neuroscience 16(2), pp. 115-117. (10.1038/nn.3313)
2012
- Wade, J., McDaid, L., Harkin, J. and Crunelli, V. 2012. Self-repair in a bidirectionally coupled astrocyte-neuron (AN) system based on retrograde signaling. Frontiers in Computational Neuroscience 6 (10.3389/fncom.2012.00076)
- Leresche, N., Lambert, R. C., Errington, A. C. and Crunelli, V. 2012. From sleep spindles of natural sleep to spike and wave discharges of typical absence seizures: is the hypothesis still valid?. Pflügers Archiv European Journal of Physiology 463(1), pp. 201-212. (10.1007/s00424-011-1009-3)
- Crunelli, V., Lőrincz, M. L., Errington, A. C. and Hughes, S. W. 2012. Activity of cortical and thalamic neurons during the slow (<1 Hz) rhythm in the mouse in vivo. Pflügers Archiv European Journal of Physiology 463(1), pp. 73-88. (10.1007/s00424-011-1011-9)
- Errington, A. C., Hughes, S. W. and Crunelli, V. 2012. Rhythmic dendritic Ca2+ oscillations in thalamocortical neurons during slow non-REM sleep-related activity in vitro. The Journal of Physiology 590(16), pp. 3691-3700. (10.1113/jphysiol.2012.232132)
2011
- Crunelli, V., Cope, D. W. and Terry, J. R. 2011. Transition to absence seizures and the role of GABAA receptors. Epilepsy Research 97(3), pp. 283-289. (10.1016/j.eplepsyres.2011.07.011)
- Crunelli, V., Errington, A. C., Hughes, S. W. and Toth, T. 2011. The thalamic low-threshold Ca2+ potential: a key determinant of the local and global dynamics of the slow (<1 Hz) sleep oscillation in thalamocortical networks. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 369(1952), pp. 3820-3839. (10.1098/rsta.2011.0126)
- Wade, J., McDaid, L. J., Harkin, J., Crunelli, V., Kelso, J. A. S. and Beiu, V. 2011. Exploring retrograde signaling via astrocytes as a mechanism for self repair. Presented at: Neural Networks (IJCNN), The 2011 International Joint Conference on, San Jose, CA, United States, July 31 - Aug 5 2011 Presented at Wade, J. J. et al. eds.The 2011 International Joint Conference on Neural Networks (IJCNN),. , (10.1109/IJCNN.2011.6033638)
- Hughes, S. W., Lőrincz, M., Parri, H. R. and Crunelli, V. 2011. Infraslow (<0.1Hz) oscillations in thalamic relay nuclei: basic mechanisms and significance to health and disease states. Presented at: 26th International Summer School of Brain Research, Amsterdam, Netherlands, 29 June-2 July 2010 Presented at Van Someren, E. J. W. et al. eds.Slow Brain Oscillations of Sleep, Resting State and Vigilance: proceedings of the 26th International Summer School of Brain Research. Progress in brain research Vol. 193. Elsevier pp. 145-162., (10.1016/B978-0-444-53839-0.00010-7)
- Errington, A. C., Di Giovanni, G., Crunelli, V. and Cope, D. W. 2011. mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus. Journal of Neuroscience 31(23), pp. 8669-8680. (10.1523/JNEUROSCI.0317-11.2011)
- Errington, A. C., Gibson, K. M., Crunelli, V. and Cope, D. W. 2011. Aberrant GABAA receptor-mediated inhibition in cortico-thalamic networks of succinic semialdehyde dehydrogenase deficient mice. PLoS ONE 6(4), article number: e19021. (10.1371/journal.pone.0019021)
- Wade, J. J., McDaid, L. J., Harkin, J., Crunelli, V. and Kelso, J. A. S. 2011. Bidirectional Coupling between Astrocytes and Neurons Mediates Learning and Dynamic Coordination in the Brain: A Multiple Modeling Approach. PLoS ONE 6(12), article number: e29445. (10.1371/journal.pone.0029445)
- Errington, A. C., Cope, D. W. and Crunelli, V. 2011. Augmentation of Tonic GABAA Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABAA Receptors. Advances in Pharmacological Sciences 2011, article number: 790590. (10.1155/2011/790590)
2010
- Crunelli, V., Leresche, N. and Cope, D. W. 2010. GABAergic gain-of-function in absence seizures. Epilepsia 51(S5), pp. 23. (10.1111/j.1528-1167.2010.02809.x)
- Errington, A. C., Renger, J., Uebele, V. and Crunelli, V. 2010. State-dependent firing determines intrinsic dendritic Ca2+ signaling in thalamocortical neurons. Journal of Neuroscience 30(44), pp. 14843-14853. (10.1523/JNEUROSCI.2968-10.2010)
- Parri, H. R., Gould, T. M. and Crunelli, V. 2010. Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats. European Journal of Neuroscience 32(1), pp. 29-40. (10.1111/j.1460-9568.2010.07281.x)
- Watson, J. et al. 2010. Gamma-hydroxybutyrate does not maintain self-administration but induces conditioned place preference when injected in the ventral tegmental area. International Journal of Neuropsychopharmacology 13(2), pp. 143-53. (10.1017/S1461145709990186)
- Dreyfus, F. M. et al. 2010. Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I-Twindow. Journal of Neuroscience 30(1), pp. 99-109. (10.1523/JNEUROSCI.4305-09.2010)
- Crunelli, V. and Hughes, S. W. 2010. The slow (< 1Hz) sleep rhythm: A dialogue of three cardinal oscillators. Nature Neuroscience 13(1), pp. 9-17. (10.1038/nn.2445)
2009
- Cope, D. W. et al. 2009. Enhanced tonic GABA(A) inhibition in typical absence epilepsy. Nature Medicine 15(12), pp. 1392-1398. (10.1038/nm.2058)
- Lorincz, M. L., Kékesi, K. A., Juhász, G., Crunelli, V. and Hughes, S. W. 2009. Temporal framing of thalamic relay-mode firing by phasic inhibition during the Alpha Rhythm. Neuron 63(5), pp. 683-696. (10.1016/j.neuron.2009.08.012)
- Lorincz, M. L., Geall, F., Bao, Y., Crunelli, V. and Hughes, S. W. 2009. ATP-dependent infra-slow (<0.1 Hz) oscillations in thalamic networks. PLoS ONE 4(2), article number: e4447. (10.1371/journal.pone.0004447)
- Chahboune, H. et al. 2009. DTI abnormalities in anterior corpus callosum of rats with spike-wave epilepsy. NeuroImage 47(2), pp. 459-466. (10.1016/j.neuroimage.2009.04.060)
2008
- Lorincz, M. L. ., Crunelli, V. and Hughes, S. W. 2008. Cellular dynamics of cholinergically induces alpha (8-13 Hz) rhythms in sensory thalamic nuclei in vitro. Journal of Neuroscience 28(3), pp. 660-671. (10.1523/JNEUROSCI.4468-07.2008)
- Blethyn, K. L., Hughes, S. W. and Crunelli, V. 2008. Evidence for electrical synapses between neurons of the nucleus reticularis thalami in the adult brain in vitro. Thalamus and Related Systems 4(1), pp. 13-20. (10.1017/S1472928807000325)
- Destexhe, A. and Crunelli, V. 2008. Methods for computational neuroscience. Journal of Neuroscience Methods 169(2), pp. 269-70. (10.1016/j.jneumeth.2008.01.025)
- Hughes, S. W. et al. 2008. Novel modes of rhythmic burst firing at cognitively-relevant frequencies in thalamocortical neurons. Brain Research 1235, pp. 12-20. (10.1016/j.brainres.2008.06.029)
- Hughes, S. W., Lorincz, M., Cope, D. W. and Crunelli, V. 2008. NeuReal: an interactive simulation system for implementing artificial dendrites and large hybrid networks. Journal of Neuroscience Methods 169(2), pp. 290-301. (10.1016/j.jneumeth.2007.11.010)
2007
- Tóth, T. I., Bessaïh, T., Leresche, N. and Crunelli, V. 2007. The properties of reticular thalamic neuron GABAA IPSCs of absence epilepsy rats lead to enhanced network excitability. European Journal of Neuroscience 26(7), pp. 1832-1844. (10.1111/j.1460-9568.2007.05800.x)
- Crunelli, V. and Gerhardt, G. 2007. Editorial. Journal of Neuroscience Methods 163(2), pp. 189. (10.1016/j.jneumeth.2007.05.015)
- Destexhe, A., Hughes, S. W., Rudolph, M. and Crunelli, V. 2007. Are corticothalamic ‘up’ states fragments of wakefulness?. Trends in Neurosciences 30(7), pp. 334-342. (10.1016/j.tins.2007.04.006)
- Hughes, S. W. and Crunelli, V. 2007. Just a phase they're going through: The complex interaction of intrinsic high-threshold bursting and gap junctions in the generation of thalamic α and θ rhythms. International Journal of Psychophysiology 64(1), pp. 3-17. (10.1016/j.ijpsycho.2006.08.004)
- Parri, R. and Crunelli, V. 2007. Astrocytes target presynaptic NMDA receptors to give synapses a boost. Nature Neuroscience 10(3), pp. 271-273. (10.1038/nn0307-271)
2006
- Crunelli, V. 2006. Pathophysiological mechanisms of absence seizures. Epilepsia 47(Supp 3), pp. 262-262. (10.1111/j.1528-1167.2006.00715_80.x)
- Zhu, L., Blethyn, K. L., Cope, D. W., Tsomaia, V., Crunelli, V. and Hughes, S. W. 2006. Nucleus- and species-specific properties of the slow (<1 hz) sleep oscillation in thalamocortical neurons. Neuroscience 141(2), pp. 621-36. (10.1016/j.neuroscience.2006.04.069)
- Blethyn, K. L., Hughes, S. W., Tóth, T. I., Cope, D. W. and Crunelli, V. 2006. Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro. Journal of Neuroscience 26(9), pp. 2474-2486. (10.1523/JNEUROSCI.3607-05.2006)
- Bessaih, T. et al. 2006. Nucleus-specific abnormalities of GABAergic synaptic transmission in a genetic model of absence seizures. Journal of Neurophysiology 96(6), pp. 3074-3081. (10.1152/jn.00682.2006)
- Crunelli, V., Cope, D. W. and Hughes, S. W. 2006. Thalamic T-type Ca2+ channels and NREM sleep. Cell Calcium 40(2), pp. 175-190. (10.1016/j.ceca.2006.04.022)
- Crunelli, V., Emri, Z. and Leresche, N. 2006. Unravelling the brain targets of γ-hydroxybutyric acid. Current Opinion in Pharmacology 6(1), pp. 44-52. (10.1016/j.coph.2005.10.001)
2005
- Cope, D. W., Hughes, S. W. and Crunelli, V. 2005. GABAA Receptor-Mediated Tonic Inhibition in Thalamic Neurons. Journal of Neuroscience 25(50), pp. 11553-11563. (10.1523/JNEUROSCI.3362-05.2005)
- Hughes, S. W. and Crunelli, V. 2005. Thalamic mechanisms of EEG alpha rhythms and their pathological implications. The Neuroscientist 11(4), pp. 357-372. (10.1177/1073858405277450)
- Holter, J., Davies, J., Leresche, N., Crunelli, V. and Carter, D. 2005. Identification of two further splice variants of GABABR1 characterizes the conserved micro-exon 4 as a hot spot for regulated splicing in the rat brain. Journal of Molecular Neuroscience 26(1), pp. 99-108. (10.1385/JMN:26:1:099)
- Crunelli, V., Toth, T. I., Cope, D., Blethyn, K. and Hughes, S. W. 2005. The "window' T-type calcium current in brain dynamics of different behavioural states. The Journal of Physiology 562(1), pp. 121-129. (10.1113/jphysiol.2004.076273)
- Holter, J., Carter, D., Leresche, N., Crunelli, V. and Vincent, P. 2005. A TASK3 channel (KCNK9) mutation in a genetic model of absence epilepsy. Journal of Molecular Neuroscience 25(1), pp. 37-51. (10.1385/JMN:25:1:037)
2004
- Hughes, S. W. et al. 2004. Synchronized oscillations at alpha and theta frequencies in the lateral geniculate nucleus. Neuron, pp. 253-268. (10.1016/S0896-6273(04)00191-6)
- Manning, J. P. A., Richards, D. A., Leresche, N., Crunelli, V. and Bowery, N. G. 2004. Cortical-area specific block of genetically determined absence seizures by ethosuximide. Neuroscience 123(1), pp. 5-9. (10.1016/j.neuroscience.2003.09.026)
2003
- Gervasi, N., Monnier, Z., Vincent, P., Paupardin-Tritsch, D., Hughes, S. W., Crunelli, V. and Leresche, N. 2003. Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures. Journal of Neuroscience 23(36), pp. 11469-11478.
- Richards, D. A. et al. 2003. Targeting thalamic nuclei is not sufficient for the full anti-absence action of ethosuximide in a rat model of absence epilepsy. Epilepsy Research 54(2-3), pp. 97-107. (10.1016/S0920-1211(03)00060-3)
- Emri, Z., Antal, K. and Crunelli, V. 2003. The impact of corticothalamic feedback on the output dynamics of a thalamocortical neurone model: The role of synapse location and metabotropic glutamate receptors. Neuroscience 117(1), pp. 229-239. (10.1016/S0306-4522(02)00759-5)
- Parri, R. and Crunelli, V. 2003. An astrocyte bridge from synapse to blood flow. Nature Neuroscience 6(1), pp. 5-6. (10.1038/nn0103-5)
- Parri, H. R. and Crunelli, V. 2003. The role of Ca2+ in the generation of spontaneous astrocytic Ca2+ oscillations. Neuroscience 120(4), pp. 979-992. (10.1016/S0306-4522(03)00379-8)
2002
- Crunelli, V. et al. 2002. Novel neuronal and astrocytic mechanisms in thalamocortical loop dynamics. Philosophical Transactions of the Royal Society B: Biological Sciences 357(1428), pp. 1675-1693. (10.1098/rstb.2002.1155)
- Emri, Z., Antal, K. and Crunelli, V. 2002. Regulation of thalamic output by the metabotropic glutamate receptor-mediated component of the corticothalamic EPSP; a simulation study. The Journal of Physiology 544, pp. 79p-79p.
- Parri, R. and Crunelli, V. 2002. Mechanism of spontaneous calcium oscillations in ventrobasal thalamus astrocytes. The Journal of Physiology 544, article number: SO55.
- Toth, T. I. and Crunelli, V. 2002. Large-scale neuronal network models based on a probabilistic connectivity principle. Proceedings of the Physiological Society: Cellular & Integrative Neuroscience Abstracts, article number: 544P, S07.
- Toth, T. I. and Crunelli, V. 2002. Modelling large scale neuronal networks using 'average neurones'. Neuroreport 13(14), pp. 1785-1788.
- Crunelli, V. and Leresche, N. 2002. Childhood absence epilepsy: genes, channels, neurons and networks. Nature Reviews Neuroscience 3(5), pp. 371-382. (10.1038/nrn811)
- Parri, R. and Crunelli, V. 2002. Astrocytes, spontaneity, and the developing thalamus. Journal of Physiology - Paris: An International Review Journal for the Neurosciences 96(3-4), pp. 221-230. (10.1016/S0928-4257(02)00009-8)
- Crunelli, V., Charpier, S., Leresche, N. and Slaght, S. 2002. Activity of thalamic reticular neurons during spontaneous genetically determined spike and wave discharges. Journal of Neuroscience, pp. 2323-2334.
- Hughes, S. W., Cope, D. W., Blethyn, K. L. and Crunelli, V. 2002. Cellular Mechanisms of the Slow (<1 Hz) Oscillation in Thalamocortical Neurons In Vitro.. Neuron, pp. 947-958. (10.1016/S0896-6273(02)00623-2)
- Hughes, S. W., Blethyn, K. L., Cope, D. W. and Crunelli, V. 2002. Properties and origin of spikelets in thalamocortical neurones in vitro. Neuroscience 110(3), pp. 395-401. (10.1016/S0306-4522(01)00577-2)
2001
- Parri, H. R. and Crunelli, V. 2001. Pacemaker calcium oscillations in thalamic astrocytes in situ. NeuroReport 12(18), pp. 3897-3900. (10.1097/00001756-200112210-00008)
- Holter, J. L., Humphries, A., Crunelli, V. and Carter, D. 2001. Optimisation of methods for selecting candidate genes from cDNA array screens: application to rat brain punches and pineal. Journal of Neuroscience Methods 112(2), pp. 173-184. (10.1016/S0165-0270(01)00466-6)
- Toth, T. I. and Crunelli, V. 2001. Estimation of the activation and kinetic properties of I-Na and I-K from the time course of the action potential. Journal of Neuroscience Methods 111(2), pp. 111-126. (10.1016/S0165-0270(01)00433-2)
- Crunelli, V., Gould, T. M. and Parri, H. R. 2001. Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation. Nature Neuroscience, pp. 803-812. (10.1038/90507)
Articles
- Dervinis, M. and Crunelli, V. 2024. Sleep waves in a large‐scale corticothalamic model constrained by activities intrinsic to neocortical networks and single thalamic neurons. CNS Neuroscience and Therapeutics 30(3), article number: e14206. (10.1111/cns.14206)
- Casarrubea, M. et al. 2024. A quantitative and T‐pattern analysis of anxiety‐like behavior in male GAERS, NEC, and Wistar rats bred under the same conditions, against a commercially available Wistar control group in the hole board and elevated plus maze tests. CNS Neuroscience and Therapeutics 30(3), article number: e14443. (10.1111/cns.14443)
- Neuparth-Sottomayor, M. et al. 2023. Cognitive comorbidities of experimental absence seizures are independent of anxiety. Neurobiology of Disease 186, article number: 106275. (10.1016/j.nbd.2023.106275)
- Dervinis, M. and Crunelli, V. 2023. Spike-and-wave discharges of absence seizures in a sleep waves-constrained corticothalamic model. CNS Neuroscience & Therapeutics 30(3), article number: e14204. (10.1111/cns.14204)
- Atherton, Z. et al. 2023. Higher-order thalamic nuclei facilitate the generalization and maintenance of spike-and-wave discharges of absence seizures. Neurobiology of Disease 178, article number: 106025. (10.1016/j.nbd.2023.106025)
- Crunelli, V., David, F., Morais, T. P. and Lorincz, M. L. 2023. HCN channels and absence seizures. Neurobiology of Disease 181, article number: 106107. (10.1016/j.nbd.2023.106107)
- McCafferty, C. et al. 2023. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 14(1) (10.1038/s41467-022-35535-4)
- Roebber, J. K., Lewis, P. A., Crunelli, V., Navarrete, M. and Hamandi, K. 2022. Effects of anti-seizure medication on sleep spindles and slow waves in drug-resistant epilepsy. Brain Sciences 12(10), article number: 1288. (10.3390/brainsci12101288)
- Cassar, D., Radic, M., Casarrubea, M., Crunelli, V. and Di Giovanni, G. 2022. The effect of cannabinoid receptor agonist WIN 55,212–2 on anxiety-like behavior and locomotion in a genetic model of absence seizures in the elevated plus-maze. CNS Neuroscience and Therapeutics 28(8), pp. 1268-1270. (10.1111/cns.13848)
- De Deurwaerdère, P. et al. 2022. Cannabinoid 1/2 receptor activation induces strain-dependent behavioral and neurochemical changes in genetic absence epilepsy rats from Strasbourg and non-epileptic control rats. Frontiers in Cellular Neuroscience 16, article number: 886033. (10.3389/fncel.2022.886033)
- Iacone, Y. et al. 2021. Systemic administration of ivabradine, a hyperpolarization-activated cyclic nucleotide-gated channel inhibitor, blocks spontaneous absence seizures. Epilepsia 62(7), pp. 1729-1743. (10.1111/epi.16926)
- Crunelli, V., Lorincz, M. L., McCafferty, C., Regis, L. C., Leresche, N., Di Giovanni, G. and David, F. 2020. Clinical and experimental insight in pathophysiology, comorbidity and therapy of absence seizures. Brain 143(8), pp. 2341-2368. (10.1093/brain/awaa072)
- Davis, B., David, F., O’Regan, C., Adam, M., Harwood, A., Crunelli, V. and Isles, A. 2020. Impairments in sensory-motor gating and information processing in a mouse model of Ehmt1 haploinsufficiency. Brain and Neuroscience Advances 4 (10.1177/2398212820928647)
- Armada-Moreira, A. et al. 2020. Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases. Frontiers in Cellular Neuroscience 14, article number: 90. (10.3389/fncel.2020.00090)
- Xapelli, S., Diógenes, M. J., Crunelli, V., Fitzsimons, C. P. and Vaz, S. H. 2020. Editorial: glial and neural stem cells as new therapeutic targets for neurodegenerative disorders. Frontiers in Cellular Neuroscience 14, article number: 71. (10.3389/fncel.2020.00071)
- Corney, B., Widnall, C., Rees, D., Davies, J., Crunelli, V. and Carter, D. 2019. Regulatory architecture of the neuronal Cacng2/Tarpγ2 gene promoter: multiple repressive domains, a polymorphic regulatory short tandem repeat, and bidirectional organization with co-regulated lncRNAs. Journal of Molecular Neuroscience 67(2), pp. 282-294. (10.1007/s12031-018-1208-x)
- Baruchin, L. J., Ranson, A., Good, M. and Crunelli, V. 2018. Absence of neuronal response modulation with familiarity in perirhinal cortex. Neuroscience 394, pp. 23-29. (10.1016/j.neuroscience.2018.10.020)
- McCafferty, C., Connelly, W. M., Celli, R., Ngomba, R. T., Nicoletti, F. and Crunelli, V. 2018. Genetic rescue of absence seizures. CNS Neuroscience & Therapeutics 24(8), pp. 745-758. (10.1111/cns.12858)
- David, F. et al. 2018. Suppression of HCN channel function in thalamocortical neurons prevents genetically determined and pharmacologically induced absence seizures. Journal of Neuroscience 38(30), pp. 6615-6627. (10.1523/JNEUROSCI.0896-17.2018)
- Di Giovanni, G., Crunelli, V. and Rizzolatti, G. 2018. Editorial: Interdisciplinary approaches for neuropathology. CNS Neuroscience & Therapeutics 24(8), pp. 665-668. (10.1111/cns.13004)
- Bombardi, C., Venzi, M., Crunelli, V. and Di Giovanni, G. 2018. Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model. Neuropharmacology 136(Part A), pp. 56-67. (10.1016/j.neuropharm.2018.01.047)
- McCafferty, C. et al. 2018. Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures. Nature Neuroscience 21, pp. 744-756. (10.1038/s41593-018-0130-4)
- Crunelli, V. et al. 2018. Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity. Nature Reviews Neuroscience 19, pp. 107-118. (10.1038/nrn.2017.151)
- Connelly, W. M., Crunelli, V. and Errington, A. C. 2017. Variable action potential backpropagation during tonic firing and low-threshold spike bursts in thalamocortical but not thalamic reticular nucleus neurons. Journal of Neuroscience 37(21), pp. 5319-5333. (10.1523/JNEUROSCI.0015-17.2017)
- Guo, J. N. et al. 2016. Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. Lancet Neurology 15(13), pp. 1336-1345. (10.1016/S1474-4422(16)30295-2)
- Venzi, M., David, F., Bellet, J., Cavaccini, A., Bombardi, C., Crunelli, V. and Di Giovanni, G. 2016. Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures. Neuropharmacology 108, pp. 292-304. (10.1016/j.neuropharm.2016.04.016)
- Connelly, W. M., Crunelli, V. and Errington, A. C. 2016. Passive synaptic normalization and input synchrony-dependent amplification of cortical feedback in thalamocortical neuron dendrites. Journal of Neuroscience 36(13), pp. 3735-3754. (10.1523/JNEUROSCI.3836-15.2016)
- David, F., Crunelli, V., Leresche, N. and Lambert, R. C. 2016. Dynamic Analysis of the Conditional Oscillator Underlying Slow Waves in Thalamocortical Neurons. Frontiers in Neural Circuits 10, pp. 1-11., article number: 10. (10.3389/fncir.2016.00010)
- Avoli, M., Crunelli, V. and Jefferys, J. 2016. Preface for methods and models in epilepsy research. Journal of Neuroscience Methods 260, pp. 1. (10.1016/j.jneumeth.2015.11.016)
- Lidster, K. et al. 2016. Opportunities for improving animal welfare in rodent models of epilepsy and seizures. Journal of Neuroscience Methods 260, pp. 2-25. (10.1016/j.jneumeth.2015.09.007)
- Connelly, W., Laing, M., Errington, A. C. and Crunelli, V. 2016. The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level. Frontiers in Neural Circuits 9, article number: 89. (10.3389/fncir.2015.00089)
- Crunelli, V. and Di Giovanni, G. 2015. Differential control by 5-HT and 5-HT1A, 2A, 2C receptors of phasic and tonic GABAA inhibition in the visual thalamus [Letter]. CNS Neuroscience & Therapeutics 21(12), pp. 967-970. (10.1111/cns.12480)
- Connelly, W. M., Crunelli, V. and Errington, A. C. 2015. The global spike: conserved dendritic properties enable unique Ca2+ spike generation in low-threshold spiking neurons. Journal of Neuroscience 35(47), pp. 15505-15522. (10.1523/JNEUROSCI.2740-15.2015)
- Griemsmann, S. et al. 2015. Characterization of panglial gap junction networks in the thalamus, neocortex, and hippocampus reveals a unique population of glial cells. Cerebral Cortex 25(10), pp. 3420-3433. (10.1093/cercor/bhu157)
- Lorincz, M. L., Gunner, D., Bao, Y., Connelly, W. M., Isaac, J. T. R., Hughes, S. W. and Crunelli, V. 2015. A distinct class of slow (~0.2–2 Hz)) intrinsically bursting layer 5 pyramidal neurons determines UP/DOWN state dynamics in the neocortex. Journal of Neuroscience 35(14), pp. 5442-5458. (10.1523/JNEUROSCI.3603-14.2015)
- Crunelli, V., David, F., Lorincz, M. L. and Hughes, S. W. 2015. The thalamocortical network as a single slow wave-generating unit. Current Opinion in Neurobiology 31, pp. 72-80. (10.1016/j.conb.2014.09.001)
- Venzi, M., Di Giovanni, G. and Crunelli, V. 2015. A critical evaluation of the Gamma-Hydroxybutyrate (GHB) model of absence seizures. CNS Neuroscience & Therapeutics 21(2), pp. 123-140. (10.1111/cns.12337)
- Crunelli, V., Carmignoto, G. and Steinhauser, C. 2015. Novel astrocyte targets: New avenues for the therapeutic treatment of epilepsy. The Neuroscientist 21(1), pp. 62-83. (10.1177/1073858414523320)
- Gould, T. M., Chen, L., Emri, Z., Pirttimaki, T., Errington, A. C., Crunelli, V. and Parri, H. R. 2014. GABAB receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 369(1654), article number: 20130607. (10.1098/rstb.2013.0607)
- Taylor, H. L. et al. 2014. Investigating local and long-range neuronal network dynamics by simultaneous optogenetics, reverse microdialysis and silicon probe recordings in vivo. Journal of Neuroscience Methods 235, pp. 83-91. (10.1016/j.jneumeth.2014.06.031)
- Crunelli, V., David, F., Leresche, N. and Lambert, R. C. 2014. Role for T-type Ca2+ channels in sleep waves. Pflugers Archiv European Journal of Physiology 466(4), pp. 735-745. (10.1007/s00424-014-1477-3)
- Crunelli, V. and Di Giovanni, G. 2014. Monoamine modulation of tonic GABAA inhibition. Reviews in the Neurosciences 25(2), pp. 195-206. (10.1515/revneuro-2013-0059)
- David, F. et al. 2013. Essential thalamic contribution to slow waves of natural sleep. Journal of Neuroscience 33(50), article number: 19599. (10.1523/JNEUROSCI.3169-13.2013)
- Connelly, W. M., Errington, A. C. and Crunelli, V. 2013. γ-Hydroxybutyric Acid (GHB) is not an agonist of extrasynaptic GABAA receptors. PLoS ONE 8(11), article number: e79062. (10.1371/journal.pone.0079062)
- Connelly, W. M., Errington, A. C., Giovanni, G. D. and Crunelli, V. 2013. Metabotropic regulation of extrasynaptic GABAA receptors. Frontiers in Neural Circuits 7, article number: 171. (10.3389/fncir.2013.00171)
- Yagüe, J. G., Cavaccini, A., Errington, A. C., Crunelli, V. and Di Giovanni, G. 2013. Dopaminergic modulation of tonic but not phasic GABAA-receptor-mediated current in the ventrobasal thalamus of Wistar and GAERS rats. Experimental Neurology 247, pp. 1-7. (10.1016/j.expneurol.2013.03.023)
- Pirttimaki, T., Parri, H. R. and Crunelli, V. 2013. Astrocytic GABA transporter GAT-1 dysfunction in experimental absence seizures. The Journal of Physiology 591(4), pp. 823-833. (10.1113/jphysiol.2012.242016)
- Lambert, R. C., Bessaïh, T., Crunelli, V. and Leresche, N. 2013. The many faces of T-type calcium channels. Pflugers Archiv European Journal of Physiology 466(3), pp. 415-423. (10.1007/s00424-013-1353-6)
- Wade, J., McDaid, L., Harkin, J., Crunelli, V. and Kelso, S. 2013. Biophysically based computational models of astrocyte ~ neuron coupling and their functional significance. Frontiers in Computational Neuroscience 7, article number: 44. (10.3389/fncom.2013.00044)
- Connelly, W. M., Fyson, S. J., Errington, A. C., McCafferty, C. P., Cope, D. W., Di Giovanni, G. and Crunelli, V. 2013. GABAB receptors regulate extrasynaptic GABAa receptors. Journal of Neuroscience 33(9), pp. 3780-3785. (10.1523/JNEUROSCI.4989-12.2013)
- Crunelli, V. and Carmignoto, G. 2013. New vistas on astroglia in convulsive and non-convulsive epilepsy highlight novel astrocytic targets for treatment. The Journal of Physiology 591(4), pp. 775-785. (10.1113/jphysiol.2012.243378)
- Hughes, S. and Crunelli, V. 2013. UP states rise from the depths. Nature Neuroscience 16(2), pp. 115-117. (10.1038/nn.3313)
- Wade, J., McDaid, L., Harkin, J. and Crunelli, V. 2012. Self-repair in a bidirectionally coupled astrocyte-neuron (AN) system based on retrograde signaling. Frontiers in Computational Neuroscience 6 (10.3389/fncom.2012.00076)
- Leresche, N., Lambert, R. C., Errington, A. C. and Crunelli, V. 2012. From sleep spindles of natural sleep to spike and wave discharges of typical absence seizures: is the hypothesis still valid?. Pflügers Archiv European Journal of Physiology 463(1), pp. 201-212. (10.1007/s00424-011-1009-3)
- Crunelli, V., Lőrincz, M. L., Errington, A. C. and Hughes, S. W. 2012. Activity of cortical and thalamic neurons during the slow (<1 Hz) rhythm in the mouse in vivo. Pflügers Archiv European Journal of Physiology 463(1), pp. 73-88. (10.1007/s00424-011-1011-9)
- Errington, A. C., Hughes, S. W. and Crunelli, V. 2012. Rhythmic dendritic Ca2+ oscillations in thalamocortical neurons during slow non-REM sleep-related activity in vitro. The Journal of Physiology 590(16), pp. 3691-3700. (10.1113/jphysiol.2012.232132)
- Crunelli, V., Cope, D. W. and Terry, J. R. 2011. Transition to absence seizures and the role of GABAA receptors. Epilepsy Research 97(3), pp. 283-289. (10.1016/j.eplepsyres.2011.07.011)
- Crunelli, V., Errington, A. C., Hughes, S. W. and Toth, T. 2011. The thalamic low-threshold Ca2+ potential: a key determinant of the local and global dynamics of the slow (<1 Hz) sleep oscillation in thalamocortical networks. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 369(1952), pp. 3820-3839. (10.1098/rsta.2011.0126)
- Errington, A. C., Di Giovanni, G., Crunelli, V. and Cope, D. W. 2011. mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus. Journal of Neuroscience 31(23), pp. 8669-8680. (10.1523/JNEUROSCI.0317-11.2011)
- Errington, A. C., Gibson, K. M., Crunelli, V. and Cope, D. W. 2011. Aberrant GABAA receptor-mediated inhibition in cortico-thalamic networks of succinic semialdehyde dehydrogenase deficient mice. PLoS ONE 6(4), article number: e19021. (10.1371/journal.pone.0019021)
- Wade, J. J., McDaid, L. J., Harkin, J., Crunelli, V. and Kelso, J. A. S. 2011. Bidirectional Coupling between Astrocytes and Neurons Mediates Learning and Dynamic Coordination in the Brain: A Multiple Modeling Approach. PLoS ONE 6(12), article number: e29445. (10.1371/journal.pone.0029445)
- Errington, A. C., Cope, D. W. and Crunelli, V. 2011. Augmentation of Tonic GABAA Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABAA Receptors. Advances in Pharmacological Sciences 2011, article number: 790590. (10.1155/2011/790590)
- Crunelli, V., Leresche, N. and Cope, D. W. 2010. GABAergic gain-of-function in absence seizures. Epilepsia 51(S5), pp. 23. (10.1111/j.1528-1167.2010.02809.x)
- Errington, A. C., Renger, J., Uebele, V. and Crunelli, V. 2010. State-dependent firing determines intrinsic dendritic Ca2+ signaling in thalamocortical neurons. Journal of Neuroscience 30(44), pp. 14843-14853. (10.1523/JNEUROSCI.2968-10.2010)
- Parri, H. R., Gould, T. M. and Crunelli, V. 2010. Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats. European Journal of Neuroscience 32(1), pp. 29-40. (10.1111/j.1460-9568.2010.07281.x)
- Watson, J. et al. 2010. Gamma-hydroxybutyrate does not maintain self-administration but induces conditioned place preference when injected in the ventral tegmental area. International Journal of Neuropsychopharmacology 13(2), pp. 143-53. (10.1017/S1461145709990186)
- Dreyfus, F. M. et al. 2010. Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I-Twindow. Journal of Neuroscience 30(1), pp. 99-109. (10.1523/JNEUROSCI.4305-09.2010)
- Crunelli, V. and Hughes, S. W. 2010. The slow (< 1Hz) sleep rhythm: A dialogue of three cardinal oscillators. Nature Neuroscience 13(1), pp. 9-17. (10.1038/nn.2445)
- Cope, D. W. et al. 2009. Enhanced tonic GABA(A) inhibition in typical absence epilepsy. Nature Medicine 15(12), pp. 1392-1398. (10.1038/nm.2058)
- Lorincz, M. L., Kékesi, K. A., Juhász, G., Crunelli, V. and Hughes, S. W. 2009. Temporal framing of thalamic relay-mode firing by phasic inhibition during the Alpha Rhythm. Neuron 63(5), pp. 683-696. (10.1016/j.neuron.2009.08.012)
- Lorincz, M. L., Geall, F., Bao, Y., Crunelli, V. and Hughes, S. W. 2009. ATP-dependent infra-slow (<0.1 Hz) oscillations in thalamic networks. PLoS ONE 4(2), article number: e4447. (10.1371/journal.pone.0004447)
- Chahboune, H. et al. 2009. DTI abnormalities in anterior corpus callosum of rats with spike-wave epilepsy. NeuroImage 47(2), pp. 459-466. (10.1016/j.neuroimage.2009.04.060)
- Lorincz, M. L. ., Crunelli, V. and Hughes, S. W. 2008. Cellular dynamics of cholinergically induces alpha (8-13 Hz) rhythms in sensory thalamic nuclei in vitro. Journal of Neuroscience 28(3), pp. 660-671. (10.1523/JNEUROSCI.4468-07.2008)
- Blethyn, K. L., Hughes, S. W. and Crunelli, V. 2008. Evidence for electrical synapses between neurons of the nucleus reticularis thalami in the adult brain in vitro. Thalamus and Related Systems 4(1), pp. 13-20. (10.1017/S1472928807000325)
- Destexhe, A. and Crunelli, V. 2008. Methods for computational neuroscience. Journal of Neuroscience Methods 169(2), pp. 269-70. (10.1016/j.jneumeth.2008.01.025)
- Hughes, S. W. et al. 2008. Novel modes of rhythmic burst firing at cognitively-relevant frequencies in thalamocortical neurons. Brain Research 1235, pp. 12-20. (10.1016/j.brainres.2008.06.029)
- Hughes, S. W., Lorincz, M., Cope, D. W. and Crunelli, V. 2008. NeuReal: an interactive simulation system for implementing artificial dendrites and large hybrid networks. Journal of Neuroscience Methods 169(2), pp. 290-301. (10.1016/j.jneumeth.2007.11.010)
- Tóth, T. I., Bessaïh, T., Leresche, N. and Crunelli, V. 2007. The properties of reticular thalamic neuron GABAA IPSCs of absence epilepsy rats lead to enhanced network excitability. European Journal of Neuroscience 26(7), pp. 1832-1844. (10.1111/j.1460-9568.2007.05800.x)
- Crunelli, V. and Gerhardt, G. 2007. Editorial. Journal of Neuroscience Methods 163(2), pp. 189. (10.1016/j.jneumeth.2007.05.015)
- Destexhe, A., Hughes, S. W., Rudolph, M. and Crunelli, V. 2007. Are corticothalamic ‘up’ states fragments of wakefulness?. Trends in Neurosciences 30(7), pp. 334-342. (10.1016/j.tins.2007.04.006)
- Hughes, S. W. and Crunelli, V. 2007. Just a phase they're going through: The complex interaction of intrinsic high-threshold bursting and gap junctions in the generation of thalamic α and θ rhythms. International Journal of Psychophysiology 64(1), pp. 3-17. (10.1016/j.ijpsycho.2006.08.004)
- Parri, R. and Crunelli, V. 2007. Astrocytes target presynaptic NMDA receptors to give synapses a boost. Nature Neuroscience 10(3), pp. 271-273. (10.1038/nn0307-271)
- Crunelli, V. 2006. Pathophysiological mechanisms of absence seizures. Epilepsia 47(Supp 3), pp. 262-262. (10.1111/j.1528-1167.2006.00715_80.x)
- Zhu, L., Blethyn, K. L., Cope, D. W., Tsomaia, V., Crunelli, V. and Hughes, S. W. 2006. Nucleus- and species-specific properties of the slow (<1 hz) sleep oscillation in thalamocortical neurons. Neuroscience 141(2), pp. 621-36. (10.1016/j.neuroscience.2006.04.069)
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- Crunelli, V., Cope, D. W. and Hughes, S. W. 2006. Thalamic T-type Ca2+ channels and NREM sleep. Cell Calcium 40(2), pp. 175-190. (10.1016/j.ceca.2006.04.022)
- Crunelli, V., Emri, Z. and Leresche, N. 2006. Unravelling the brain targets of γ-hydroxybutyric acid. Current Opinion in Pharmacology 6(1), pp. 44-52. (10.1016/j.coph.2005.10.001)
- Cope, D. W., Hughes, S. W. and Crunelli, V. 2005. GABAA Receptor-Mediated Tonic Inhibition in Thalamic Neurons. Journal of Neuroscience 25(50), pp. 11553-11563. (10.1523/JNEUROSCI.3362-05.2005)
- Hughes, S. W. and Crunelli, V. 2005. Thalamic mechanisms of EEG alpha rhythms and their pathological implications. The Neuroscientist 11(4), pp. 357-372. (10.1177/1073858405277450)
- Holter, J., Davies, J., Leresche, N., Crunelli, V. and Carter, D. 2005. Identification of two further splice variants of GABABR1 characterizes the conserved micro-exon 4 as a hot spot for regulated splicing in the rat brain. Journal of Molecular Neuroscience 26(1), pp. 99-108. (10.1385/JMN:26:1:099)
- Crunelli, V., Toth, T. I., Cope, D., Blethyn, K. and Hughes, S. W. 2005. The "window' T-type calcium current in brain dynamics of different behavioural states. The Journal of Physiology 562(1), pp. 121-129. (10.1113/jphysiol.2004.076273)
- Holter, J., Carter, D., Leresche, N., Crunelli, V. and Vincent, P. 2005. A TASK3 channel (KCNK9) mutation in a genetic model of absence epilepsy. Journal of Molecular Neuroscience 25(1), pp. 37-51. (10.1385/JMN:25:1:037)
- Hughes, S. W. et al. 2004. Synchronized oscillations at alpha and theta frequencies in the lateral geniculate nucleus. Neuron, pp. 253-268. (10.1016/S0896-6273(04)00191-6)
- Manning, J. P. A., Richards, D. A., Leresche, N., Crunelli, V. and Bowery, N. G. 2004. Cortical-area specific block of genetically determined absence seizures by ethosuximide. Neuroscience 123(1), pp. 5-9. (10.1016/j.neuroscience.2003.09.026)
- Gervasi, N., Monnier, Z., Vincent, P., Paupardin-Tritsch, D., Hughes, S. W., Crunelli, V. and Leresche, N. 2003. Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures. Journal of Neuroscience 23(36), pp. 11469-11478.
- Richards, D. A. et al. 2003. Targeting thalamic nuclei is not sufficient for the full anti-absence action of ethosuximide in a rat model of absence epilepsy. Epilepsy Research 54(2-3), pp. 97-107. (10.1016/S0920-1211(03)00060-3)
- Emri, Z., Antal, K. and Crunelli, V. 2003. The impact of corticothalamic feedback on the output dynamics of a thalamocortical neurone model: The role of synapse location and metabotropic glutamate receptors. Neuroscience 117(1), pp. 229-239. (10.1016/S0306-4522(02)00759-5)
- Parri, R. and Crunelli, V. 2003. An astrocyte bridge from synapse to blood flow. Nature Neuroscience 6(1), pp. 5-6. (10.1038/nn0103-5)
- Parri, H. R. and Crunelli, V. 2003. The role of Ca2+ in the generation of spontaneous astrocytic Ca2+ oscillations. Neuroscience 120(4), pp. 979-992. (10.1016/S0306-4522(03)00379-8)
- Crunelli, V. et al. 2002. Novel neuronal and astrocytic mechanisms in thalamocortical loop dynamics. Philosophical Transactions of the Royal Society B: Biological Sciences 357(1428), pp. 1675-1693. (10.1098/rstb.2002.1155)
- Emri, Z., Antal, K. and Crunelli, V. 2002. Regulation of thalamic output by the metabotropic glutamate receptor-mediated component of the corticothalamic EPSP; a simulation study. The Journal of Physiology 544, pp. 79p-79p.
- Parri, R. and Crunelli, V. 2002. Mechanism of spontaneous calcium oscillations in ventrobasal thalamus astrocytes. The Journal of Physiology 544, article number: SO55.
- Toth, T. I. and Crunelli, V. 2002. Large-scale neuronal network models based on a probabilistic connectivity principle. Proceedings of the Physiological Society: Cellular & Integrative Neuroscience Abstracts, article number: 544P, S07.
- Toth, T. I. and Crunelli, V. 2002. Modelling large scale neuronal networks using 'average neurones'. Neuroreport 13(14), pp. 1785-1788.
- Crunelli, V. and Leresche, N. 2002. Childhood absence epilepsy: genes, channels, neurons and networks. Nature Reviews Neuroscience 3(5), pp. 371-382. (10.1038/nrn811)
- Parri, R. and Crunelli, V. 2002. Astrocytes, spontaneity, and the developing thalamus. Journal of Physiology - Paris: An International Review Journal for the Neurosciences 96(3-4), pp. 221-230. (10.1016/S0928-4257(02)00009-8)
- Crunelli, V., Charpier, S., Leresche, N. and Slaght, S. 2002. Activity of thalamic reticular neurons during spontaneous genetically determined spike and wave discharges. Journal of Neuroscience, pp. 2323-2334.
- Hughes, S. W., Cope, D. W., Blethyn, K. L. and Crunelli, V. 2002. Cellular Mechanisms of the Slow (<1 Hz) Oscillation in Thalamocortical Neurons In Vitro.. Neuron, pp. 947-958. (10.1016/S0896-6273(02)00623-2)
- Hughes, S. W., Blethyn, K. L., Cope, D. W. and Crunelli, V. 2002. Properties and origin of spikelets in thalamocortical neurones in vitro. Neuroscience 110(3), pp. 395-401. (10.1016/S0306-4522(01)00577-2)
- Parri, H. R. and Crunelli, V. 2001. Pacemaker calcium oscillations in thalamic astrocytes in situ. NeuroReport 12(18), pp. 3897-3900. (10.1097/00001756-200112210-00008)
- Holter, J. L., Humphries, A., Crunelli, V. and Carter, D. 2001. Optimisation of methods for selecting candidate genes from cDNA array screens: application to rat brain punches and pineal. Journal of Neuroscience Methods 112(2), pp. 173-184. (10.1016/S0165-0270(01)00466-6)
- Toth, T. I. and Crunelli, V. 2001. Estimation of the activation and kinetic properties of I-Na and I-K from the time course of the action potential. Journal of Neuroscience Methods 111(2), pp. 111-126. (10.1016/S0165-0270(01)00433-2)
- Crunelli, V., Gould, T. M. and Parri, H. R. 2001. Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation. Nature Neuroscience, pp. 803-812. (10.1038/90507)
Book sections
- Deidda, G., Pierucci, M., Crunelli, V. and Di Giovanni, G. 2021. 5-HT/GABA interaction in neurodevelopment and plasticity. In: Progress in Brain Research., Vol. 259. ELSEVIER SCIENCE BV, pp. 287-317., (10.1016/bs.pbr.2021.01.009)
- Deidda, G., Crunelli, V. and Di Giovanni, G. 2021. 5-HT/GABA interaction in epilepsy. In: Progress in Brain Research., Vol. 259. ELSEVIER, pp. 265-286., (10.1016/bs.pbr.2021.01.008)
Conferences
- Wade, J., McDaid, L. J., Harkin, J., Crunelli, V., Kelso, J. A. S. and Beiu, V. 2011. Exploring retrograde signaling via astrocytes as a mechanism for self repair. Presented at: Neural Networks (IJCNN), The 2011 International Joint Conference on, San Jose, CA, United States, July 31 - Aug 5 2011 Presented at Wade, J. J. et al. eds.The 2011 International Joint Conference on Neural Networks (IJCNN),. , (10.1109/IJCNN.2011.6033638)
- Hughes, S. W., Lőrincz, M., Parri, H. R. and Crunelli, V. 2011. Infraslow (<0.1Hz) oscillations in thalamic relay nuclei: basic mechanisms and significance to health and disease states. Presented at: 26th International Summer School of Brain Research, Amsterdam, Netherlands, 29 June-2 July 2010 Presented at Van Someren, E. J. W. et al. eds.Slow Brain Oscillations of Sleep, Resting State and Vigilance: proceedings of the 26th International Summer School of Brain Research. Progress in brain research Vol. 193. Elsevier pp. 145-162., (10.1016/B978-0-444-53839-0.00010-7)
Ymchwil
My research focuses on the cellular and network mechanisms operating in the thalamus and cortex during sleep and absence epilepsy.
Recently, we also developed an interest in the mechanisms involved in astrocyte-neuron signalling.
My multi-disciplinary group uses a combination of electrophysiological, morphological, immunocytochemical and confocal imaging techniques both in normal and transgenic in vivo and in vitro animal models, as well as a computational approach for simulations of neuronal and astrocytic network activities.
Sleep mechanisms
One of the most fundamental electrical activities that occurs in thalamic and cortical neurons during natural sleep is the 'slow sleep oscillation'. The top panel in Figure 1 below shows a typical example of this activity recorded from a thalamic neuron.
The 'slow sleep oscillation' is characterized by the presence of two membrane potentials (called UP and DOWN states), which are generated by the switching 'on' and 'off' of the window component of the low-voltage activated, T-type Ca2+ current (I T). In the bottom panel of Figure 1, the other two neuronal currents that play a critical role in the slow oscillations are illustrated, i.e. I h, hyperpolarization-activated Na +/K + current, and I CAN, Ca2+-activated non-selective cation current. Further details in our publications: Hughes et al., Neuron 33 (2002) 947-958; Blethyn et al., Journal of Neuroscience 26 (2006) 2474-2486; Crunelli et al., Cell Calcium 40 (2006) 175-190; and Destexhe et al., Trends in Neuroscience 30 (2007) 334-342.
Pathophysiological mechanisms of Absence Epilepsy
Absence epilepsy is a non-convulsive form of epilepsy that mainly affects children and teenagers. Each seizure consists of a sudden and brief impairment of consciousness, which is accompanied by a vacant stare, lack of response to external stimuli, and the appearance in the EEG of a characteristic pathological activity, called a 'spike-and-wave discharge' (illustrated in Figure 2A, right).
The 'spike-and-wave discharge' is generated by the abnormal electrical activities of cortical and thalamic neurons (depicted in Figure 2B-D, colour code refers to the different cell types illustrated in the schematic diagram). Note the very strong firing of the GABAergic neurons in the nucleus reticularis thalami (NRT) (see movie below) and the electrical silence of the thalamocortical (TC) neurons.
Since TC neurons are those that transfer sensory stimuli, their hyperpolarization and lack of firing explain why children are unresponsive during an absence seizure.
Further details in our publications: Crunelli and Leresche, Nature Reviews Neuroscience, 3 (2002) 371-382; Slaght et al. Journal of Neuroscience 22 (2002) 2323-2334; and Manning et al., Neuroscience 123 (2004) 5-9.
Astrocyte-neuron signalling
Astrocytes (a type of glial cells) are no longer thought of as only providing mechanical support for neurons and controlling the extracellular concentration of key ions and metabolites, but have been shown to contribute actively to the transfer of neuronal information at the synaptic level.
Since astrocytes are non-excitable cells their 'activation' consists of transients rises in intracellular Ca2+ which then leads to the vesicular release of transmitters, including glutamate and ATP.
These astrocytically released substances then act on neurons (preferentially activating NMDA receptors) modulating transmitter release or controlling synaptic efficacy. Indeed, astrocytes can even generate spontaneous and localized, intracellular Ca2+ waves in the absence of any neuronal activity.
Further details in our publications: Parri et al., Nature Neuroscience 4 (2001) 803-812; Parri et al., Neuroscience 120 (2003) 979-992; and Parri and Crunelli Nature Neuroscience 10 (2007) 271-273
Group facilities
My laboratory is equipped with six electrophysiological stations (three for patch- and three for sharp-electrode recordings), one confocal microscope (Odyssey, Thermo Noran, USA) with in vitro patch-electrode recording facilities, one 2-photon laser scanning microscope (Ultima, Prairie Technology, USA) with in vivo and in vitro patch- and sharp-electrode recording facilities, a suite for in vivo electrical recordings and localized drug application in freely moving models, one cluster of 11 dual-processor nodes for computer simulations, in-house developed software for dynamic clamp experiments, and facilities for post-hoc morphological and immunocytochemical analysis of neurons and astrocytes.
Current grants
Cellular thalamic mechanisms under physiological and pathological conditions
Source: The Wellcome Trust
Duration: 5 years (from October 2003) (Programme Grant)
Amount: £ 1,246,652
Neuronal thalamic gap junctions: identity, location and role in slow EEG rhythms of (patho)physiological states
Source: The Wellcome Trust
Duration: 3 years (from January 2006)
Amount: £ 239,867
Molecular and cellular investigation of neuron-astroglia interactions: Understanding brain function and dysfunction
Source: The European Union (FP7)
Duration: 4 years (from January 2008) (with 5 partners)
Amount: £ 2,104,762
Addysgu
Yn Ysgol y Biowyddorau ym Mhrifysgol Caerdydd, rwy'n addysgu niwrowyddoniaeth a niwroffisioleg i fyfyrwyr gwyddoniaeth israddedig (modiwlau Bi2432, BI3451, Bi3452) ac i fyfyrwyr deintyddol. Yn y Gyfadran Meddygaeth a Llawfeddygaeth ym Mhrifysgol Malta, rwy'n addysgu niwrowyddoniaeth a chlefydau niwrolegol i fyfyrwyr meddygol.
Rwyf hefyd yn goruchwylio myfyrwyr Meistr a PhD yn y ddwy Brifysgol.
Bywgraffiad
- Laurea (Pure Chemistry), University of Catania, Catania, Italy (1974)
- Postdoctoral Research Associate, Laboratory of Neuropharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy (1976-1978)
- Postdoctoral Research Associate, Medical Research Council, Neurochemical Pharmacology Unit, Cambridge, UK (1979)
- Postdoctoral Research Associate, Center for Neuroscience, Weizmann Institute of Science, Rehovot, Israel (1980)
Anrhydeddau a dyfarniadau
- Fellow, Academy of Medical Sciences (elected (2010)
- Fellow, Academia Europaea (elected 2010)
- Fellow, Malta Chamber of Scientists (elected 2012)
- Fellow, Learned society of Wales (elected 2012)
Safleoedd academaidd blaenorol
- Wellcome Trust Research Fellow, Department of Pharmacology, St. George's Hospital Medical School, London, UK (1981-1984)
- Wellcome Trust Lecturer, Department of Pharmacology, St. George's Hospital Medical School, London, UK (1985)
- Lecturer in Pharmacology, Department of Pharmacology, St. George's Hospital Medical School, London, UK (1986-1988)
- Senior Lecturer in Pharmacology, Department of Pharmacology, St. George's Hospital Medical School, London, UK (1989)
- Senior Lecturer in Visual Science, Department of Visual Science, Institute of Ophthalmology, London, UK (1989-1991)
- Professor of Neuroscience, School of Biosciences, Cardiff University, Cardiff, UK (1991-to date)
- Head, Department of Physiology, Cardiff University, Cardiff, UK (1994-1998)
- Visiting Professor, Université Pierre et Marie Curie, 9 quai Saint-Bernard, Paris, France (1998-2002)
- Head, Neuroscience Division, School of Biosciences, Cardiff University, Cardiff, UK (2011-2015)
- Affiliate Professor, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta (2016-to date)
Pwyllgorau ac adolygu
- Editor-in-Chief, Journal of Neuroscience Methods (1999- 2017)
- Editor, British Journal of Pharmacology (1991-1996)
- Editor, Neuron Glia Biology (2001-2013)
- Editor, Thalamus and Related Systems (2003-2009)
- Editor, Journal of Neural Systems (2004-2008)
- Advisory Editor, Xjenza Online (2012-to date)