![Charlotte Dennison](https://profiles-cardiff.imgix.net/attachments/4394?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Charlotte Dennison
(hi/ei)
Timau a rolau for Charlotte Dennison
Cydymaith Ymchwil, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol
Trosolwyg
Rwy'n ymchwilydd yng Nghanolfan Wolfson ar gyfer Iechyd Meddwl Pobl Ifanc a'r Ganolfan Geneteg a Genomeg Niwroseiciatrig. Mae fy niddordebau yn canolbwyntio ar gyflyrau niwroddatblygiadol, geneteg, a seicosis, gyda phwyslais arbennig ar lwybrau datblygiadol i salwch meddwl difrifol a'r trawsnewidiad o anawsterau iechyd meddwl ieuenctid i gyflyrau seiciatrig oedolion. Mae fy ymchwil bresennol yn canolbwyntio ar iselder a gorbryder mewn pobl ifanc, gan dynnu ar ddata genomig i nodweddu risg a heterogenedd yn ystod cyfnodau datblygiadol allweddol. Nod y gwaith hwn yw nodi cyfleoedd ar gyfer cyfieithu clinigol o ganfyddiadau genetig, gan gynnwys gwerthuso sut y gellid defnyddio data genomig i gefnogi haenu risg a gofal personol mewn lleoliadau iechyd meddwl.
Cyhoeddiad
2026
- Rahali, Y. et al., 2026. Attention deficit hyperactivity disorder (ADHD) and premature mortality: A narrative review of the literature. European Child and Adolescent Psychiatry (10.1007/s00787-026-03156-7)
- Dennison, C. A. et al. 2026. Childhood ADHD and autism spectrum disorder difficulties: exploring the impact of copy number variants on young adult outcomes. BJPsych Open 12 (3) e108. (10.1192/bjo.2026.11018)
- Dennison, C. A. et al. 2026. The role of rare copy number variants in early‐onset depression. JCPP Advances e70128. (10.1002/jcv2.70128)
- Shakeshaft, A. et al. 2026. Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis. Journal of Child Psychology and Psychiatry 67 (3), pp.333-343. jcpp.70040. (10.1111/jcpp.70040)
2025
- Horstmann, L. et al. 2025. Attention Deficit Hyperactivity Disorder and other neurodevelopmental traits are associated with impact on functioning among children in the general population. JCPP Advances 5 (4) e70004. (10.1002/jcv2.70004)
- Dennison, C. A. et al. 2025. Early manifestations of neurodevelopmental copy number variants in children: A population-based investigation. Biological Psychiatry 98 (12), pp.924-933. (10.1016/j.biopsych.2025.03.004)
- Thapar, A. et al. 2025. Youth depression: An overview of genetic findings and the challenge of heterogeneity. Journal of Affective Disorders 391 120049. (10.1016/j.jad.2025.120049)
- Shakeshaft, A. et al. 2025. Investigating irritability as a potentially causal risk pathway into depression using two genetically informed designs. Biological Society: Global Open Science 5 (6) 100566. (10.1016/j.bpsgos.2025.100566)
- Tseliou, F. et al. 2025. Factors associated with better emotional, behavioural and educational outcomes in children with mild intellectual difficulties. JCPP Advances e70072. (10.1002/jcv2.70072)
- Rammos, A. et al., 2025. Copy number variants and their implications for developmental and behavioural problems in cleft lip and/or palate. Human Molecular Genetics 34 (18), pp.1563-1574. (10.1093/hmg/ddaf115)
2024
- Riglin, L. et al. 2024. Emotional problems across development: examining measurement invariance across childhood, adolescence and early adulthood. European Child and Adolescent Psychiatry 33 , pp.4237-4245. (10.1007/s00787-024-02461-3)
- Dennison, C. A. et al. 2024. Investigating the neurodevelopmental correlates of early adolescent-onset emotional problems. Journal of Affective Disorders 364 , pp.212-220. (10.1016/j.jad.2024.08.008)
- Tseliou, F. et al. 2024. Childhood correlates and young adult outcomes of trajectories of emotional problems from childhood to adolescence. Psychological Medicine 54 (10), pp.2504-2514. (10.1017/S0033291724000631)
- Shakeshaft, A. et al. 2024. Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems. Molecular Psychiatry 29 , pp.238-246. (10.1038/s41380-023-02319-1)
- Shakeshaft, A. et al. 2024. Long-term physical health conditions and youth anxiety and depression: Is there a causal link?. Psychological Medicine 55 e7. (10.1017/S0033291724003271)
- Dennison, C. et al. 2024. Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry. Journal of Child Psychology and Psychiatry 65 (1), pp.42-51. (10.1111/jcpp.13862)
2023
- Armitage, J. M. et al. 2023. Validation of the Strengths and Difficulties Questionnaire (SDQ) emotional subscale in assessing depression and anxiety across development. PLoS ONE 18 (7) e0288882. (10.1371/journal.pone.0288882)
2022
- Creeth, H. D. J. et al. 2022. Ultrarare coding variants and cognitive function in schizophrenia. JAMA Psychiatry 79 (10), pp.963-970. (10.1001/jamapsychiatry.2022.2289)
- Trubetskoy, V. et al., 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604 , pp.502-508. (10.1038/s41586-022-04434-5)
- Vassos, E. et al., 2022. Lack of support for the genes by early environment interaction hypothesis in the pathogenesis of schizophrenia. Schizophrenia Bulletin 48 (1), pp.20-26. (10.1093/schbul/sbab052)
- Pardinas, A. et al. 2022. Interaction testing and polygenic risk scoring to estimate the contribution of common genetic variants to treatment resistance in schizophrenia. JAMA Psychiatry 79 (3), pp.260-269. (10.1001/jamapsychiatry.2021.3799)
2021
- Dennison, C. et al. 2021. Risk factors, clinical features, and polygenic risk scores in schizophrenia and schizoaffective disorder depressive-type. Schizophrenia Bulletin 47 (5), pp.1375-1384. (10.1093/schbul/sbab036)
- Legge, S. et al. 2021. Associations between schizophrenia polygenic liability, symptom dimensions, and cognitive ability in schizophrenia. JAMA Psychiatry 78 (10), pp.1143-1151. (10.1001/jamapsychiatry.2021.1961)
- Dennison, C. A. et al. 2021. Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank. PLoS ONE 16 (3) e0249189. (10.1371/journal.pone.0249189)
- Dennison, C. 2021. Phenotypic and genotypic associations across the psychosis spectrum. PhD Thesis , Cardiff University.
2020
- Legge, S. et al. 2020. Clinical indicators of treatment-resistant psychosis. British Journal of Psychiatry 216 (5), pp.259-266. (10.1192/bjp.2019.120)
- Dennison, C. A. et al. 2020. Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective. Schizophrenia Research 217 , pp.4-12. (10.1016/j.schres.2019.10.048)
Erthyglau
- Rahali, Y. et al., 2026. Attention deficit hyperactivity disorder (ADHD) and premature mortality: A narrative review of the literature. European Child and Adolescent Psychiatry (10.1007/s00787-026-03156-7)
- Dennison, C. A. et al. 2026. Childhood ADHD and autism spectrum disorder difficulties: exploring the impact of copy number variants on young adult outcomes. BJPsych Open 12 (3) e108. (10.1192/bjo.2026.11018)
- Dennison, C. A. et al. 2026. The role of rare copy number variants in early‐onset depression. JCPP Advances e70128. (10.1002/jcv2.70128)
- Shakeshaft, A. et al. 2026. Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis. Journal of Child Psychology and Psychiatry 67 (3), pp.333-343. jcpp.70040. (10.1111/jcpp.70040)
- Horstmann, L. et al. 2025. Attention Deficit Hyperactivity Disorder and other neurodevelopmental traits are associated with impact on functioning among children in the general population. JCPP Advances 5 (4) e70004. (10.1002/jcv2.70004)
- Dennison, C. A. et al. 2025. Early manifestations of neurodevelopmental copy number variants in children: A population-based investigation. Biological Psychiatry 98 (12), pp.924-933. (10.1016/j.biopsych.2025.03.004)
- Thapar, A. et al. 2025. Youth depression: An overview of genetic findings and the challenge of heterogeneity. Journal of Affective Disorders 391 120049. (10.1016/j.jad.2025.120049)
- Shakeshaft, A. et al. 2025. Investigating irritability as a potentially causal risk pathway into depression using two genetically informed designs. Biological Society: Global Open Science 5 (6) 100566. (10.1016/j.bpsgos.2025.100566)
- Tseliou, F. et al. 2025. Factors associated with better emotional, behavioural and educational outcomes in children with mild intellectual difficulties. JCPP Advances e70072. (10.1002/jcv2.70072)
- Rammos, A. et al., 2025. Copy number variants and their implications for developmental and behavioural problems in cleft lip and/or palate. Human Molecular Genetics 34 (18), pp.1563-1574. (10.1093/hmg/ddaf115)
- Riglin, L. et al. 2024. Emotional problems across development: examining measurement invariance across childhood, adolescence and early adulthood. European Child and Adolescent Psychiatry 33 , pp.4237-4245. (10.1007/s00787-024-02461-3)
- Dennison, C. A. et al. 2024. Investigating the neurodevelopmental correlates of early adolescent-onset emotional problems. Journal of Affective Disorders 364 , pp.212-220. (10.1016/j.jad.2024.08.008)
- Tseliou, F. et al. 2024. Childhood correlates and young adult outcomes of trajectories of emotional problems from childhood to adolescence. Psychological Medicine 54 (10), pp.2504-2514. (10.1017/S0033291724000631)
- Shakeshaft, A. et al. 2024. Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems. Molecular Psychiatry 29 , pp.238-246. (10.1038/s41380-023-02319-1)
- Shakeshaft, A. et al. 2024. Long-term physical health conditions and youth anxiety and depression: Is there a causal link?. Psychological Medicine 55 e7. (10.1017/S0033291724003271)
- Dennison, C. et al. 2024. Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry. Journal of Child Psychology and Psychiatry 65 (1), pp.42-51. (10.1111/jcpp.13862)
- Armitage, J. M. et al. 2023. Validation of the Strengths and Difficulties Questionnaire (SDQ) emotional subscale in assessing depression and anxiety across development. PLoS ONE 18 (7) e0288882. (10.1371/journal.pone.0288882)
- Creeth, H. D. J. et al. 2022. Ultrarare coding variants and cognitive function in schizophrenia. JAMA Psychiatry 79 (10), pp.963-970. (10.1001/jamapsychiatry.2022.2289)
- Trubetskoy, V. et al., 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604 , pp.502-508. (10.1038/s41586-022-04434-5)
- Vassos, E. et al., 2022. Lack of support for the genes by early environment interaction hypothesis in the pathogenesis of schizophrenia. Schizophrenia Bulletin 48 (1), pp.20-26. (10.1093/schbul/sbab052)
- Pardinas, A. et al. 2022. Interaction testing and polygenic risk scoring to estimate the contribution of common genetic variants to treatment resistance in schizophrenia. JAMA Psychiatry 79 (3), pp.260-269. (10.1001/jamapsychiatry.2021.3799)
- Dennison, C. et al. 2021. Risk factors, clinical features, and polygenic risk scores in schizophrenia and schizoaffective disorder depressive-type. Schizophrenia Bulletin 47 (5), pp.1375-1384. (10.1093/schbul/sbab036)
- Legge, S. et al. 2021. Associations between schizophrenia polygenic liability, symptom dimensions, and cognitive ability in schizophrenia. JAMA Psychiatry 78 (10), pp.1143-1151. (10.1001/jamapsychiatry.2021.1961)
- Dennison, C. A. et al. 2021. Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank. PLoS ONE 16 (3) e0249189. (10.1371/journal.pone.0249189)
- Legge, S. et al. 2020. Clinical indicators of treatment-resistant psychosis. British Journal of Psychiatry 216 (5), pp.259-266. (10.1192/bjp.2019.120)
- Dennison, C. A. et al. 2020. Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective. Schizophrenia Research 217 , pp.4-12. (10.1016/j.schres.2019.10.048)
Gosodiad
- Dennison, C. 2021. Phenotypic and genotypic associations across the psychosis spectrum. PhD Thesis , Cardiff University.
Contact Details
Themâu ymchwil
Arbenigeddau
- Iechyd Meddwl
- Iselder
- Seicosis
- ADHD