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Dr Charlotte Dennison
(she/her)
Research Associate, Division of Psychological Medicine and Clinical Neurosciences
Overview
I am a post-doctoral researcher in the Wolfson Centre for Young People's Mental Health and the Centre for Neuropsychiatric Genetics and Genomics. My current research focuses on the genetic basis of depression and anxiety in young people, and I am particularly interested in identifying opportunities for clinical translation of genetics in the context of mental health.
Publication
2025
- Dennison, C. A. et al. 2025. Early manifestations of neurodevelopmental copy number variants in children: A population-based investigation. Biological Psychiatry (10.1016/j.biopsych.2025.03.004)
- Horstmann, L., Dennison, C. A., Stergiakouli, E., Langley, K. and Martin, J. 2025. Attention Deficit Hyperactivity Disorder and other neurodevelopmental traits are associated with impact on functioning among children in the general population. JCPP Advances, article number: e70004. (10.1002/jcv2.70004)
2024
- Riglin, L. et al. 2024. Emotional problems across development: examining measurement invariance across childhood, adolescence and early adulthood. European Child and Adolescent Psychiatry 33, pp. 4237-4245. (10.1007/s00787-024-02461-3)
- Dennison, C. A., Shakeshaft, A., Eyre, O., Tilling, K., Rice, F. and Thapar, A. 2024. Investigating the neurodevelopmental correlates of early adolescent-onset emotional problems. Journal of Affective Disorders 364, pp. 212-220. (10.1016/j.jad.2024.08.008)
- Tseliou, F. et al. 2024. Childhood correlates and young adult outcomes of trajectories of emotional problems from childhood to adolescence. Psychological Medicine 54(10), pp. 2504-2514. (10.1017/S0033291724000631)
- Shakeshaft, A., Martin, J., Dennison, C. A., Riglin, L., Lewis, C. M., O'Donovan, M. and Thapar, A. 2024. Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems. Molecular Psychiatry 29, pp. 238-246. (10.1038/s41380-023-02319-1)
- Shakeshaft, A. et al. 2024. Long-term physical health conditions and youth anxiety and depression: Is there a causal link?. Psychological Medicine 55, article number: e7. (10.1017/S0033291724003271)
- Dennison, C. et al. 2024. Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry. Journal of Child Psychology and Psychiatry 65(1), pp. 42-51. (10.1111/jcpp.13862)
2023
- Armitage, J. M. et al. 2023. Validation of the Strengths and Difficulties Questionnaire (SDQ) emotional subscale in assessing depression and anxiety across development. PLoS ONE 18(7), article number: e0288882. (10.1371/journal.pone.0288882)
2022
- Creeth, H. D. J. et al. 2022. Ultrarare coding variants and cognitive function in schizophrenia. JAMA Psychiatry 79(10), pp. 963-970. (10.1001/jamapsychiatry.2022.2289)
- Trubetskoy, V. et al. 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604, pp. 502-508. (10.1038/s41586-022-04434-5)
- Vassos, E. et al. 2022. Lack of support for the genes by early environment interaction hypothesis in the pathogenesis of schizophrenia. Schizophrenia Bulletin 48(1), pp. 20-26. (10.1093/schbul/sbab052)
- Pardinas, A. et al. 2022. Interaction testing and polygenic risk scoring to estimate the contribution of common genetic variants to treatment resistance in schizophrenia. JAMA Psychiatry 79(3), pp. 260-269. (10.1001/jamapsychiatry.2021.3799)
2021
- Dennison, C. et al. 2021. Risk factors, clinical features, and polygenic risk scores in schizophrenia and schizoaffective disorder depressive-type. Schizophrenia Bulletin 47(5), pp. 1375-1384. (10.1093/schbul/sbab036)
- Legge, S. et al. 2021. Associations between schizophrenia polygenic liability, symptom dimensions, and cognitive ability in schizophrenia. JAMA Psychiatry 78(10), pp. 1143-1151. (10.1001/jamapsychiatry.2021.1961)
- Dennison, C. A. et al. 2021. Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank. PLoS ONE 16(3), article number: e0249189. (10.1371/journal.pone.0249189)
- Dennison, C. 2021. Phenotypic and genotypic associations across the psychosis spectrum. PhD Thesis, Cardiff University.
2020
- Legge, S. et al. 2020. Clinical indicators of treatment-resistant psychosis. British Journal of Psychiatry 216(5), pp. 259-266. (10.1192/bjp.2019.120)
- Dennison, C. A., Legge, S. E., Pardinas, A. F. and Walters, J. T. 2020. Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective. Schizophrenia Research 217, pp. 4-12. (10.1016/j.schres.2019.10.048)
Articles
- Dennison, C. A. et al. 2025. Early manifestations of neurodevelopmental copy number variants in children: A population-based investigation. Biological Psychiatry (10.1016/j.biopsych.2025.03.004)
- Horstmann, L., Dennison, C. A., Stergiakouli, E., Langley, K. and Martin, J. 2025. Attention Deficit Hyperactivity Disorder and other neurodevelopmental traits are associated with impact on functioning among children in the general population. JCPP Advances, article number: e70004. (10.1002/jcv2.70004)
- Riglin, L. et al. 2024. Emotional problems across development: examining measurement invariance across childhood, adolescence and early adulthood. European Child and Adolescent Psychiatry 33, pp. 4237-4245. (10.1007/s00787-024-02461-3)
- Dennison, C. A., Shakeshaft, A., Eyre, O., Tilling, K., Rice, F. and Thapar, A. 2024. Investigating the neurodevelopmental correlates of early adolescent-onset emotional problems. Journal of Affective Disorders 364, pp. 212-220. (10.1016/j.jad.2024.08.008)
- Tseliou, F. et al. 2024. Childhood correlates and young adult outcomes of trajectories of emotional problems from childhood to adolescence. Psychological Medicine 54(10), pp. 2504-2514. (10.1017/S0033291724000631)
- Shakeshaft, A., Martin, J., Dennison, C. A., Riglin, L., Lewis, C. M., O'Donovan, M. and Thapar, A. 2024. Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems. Molecular Psychiatry 29, pp. 238-246. (10.1038/s41380-023-02319-1)
- Shakeshaft, A. et al. 2024. Long-term physical health conditions and youth anxiety and depression: Is there a causal link?. Psychological Medicine 55, article number: e7. (10.1017/S0033291724003271)
- Dennison, C. et al. 2024. Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry. Journal of Child Psychology and Psychiatry 65(1), pp. 42-51. (10.1111/jcpp.13862)
- Armitage, J. M. et al. 2023. Validation of the Strengths and Difficulties Questionnaire (SDQ) emotional subscale in assessing depression and anxiety across development. PLoS ONE 18(7), article number: e0288882. (10.1371/journal.pone.0288882)
- Creeth, H. D. J. et al. 2022. Ultrarare coding variants and cognitive function in schizophrenia. JAMA Psychiatry 79(10), pp. 963-970. (10.1001/jamapsychiatry.2022.2289)
- Trubetskoy, V. et al. 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604, pp. 502-508. (10.1038/s41586-022-04434-5)
- Vassos, E. et al. 2022. Lack of support for the genes by early environment interaction hypothesis in the pathogenesis of schizophrenia. Schizophrenia Bulletin 48(1), pp. 20-26. (10.1093/schbul/sbab052)
- Pardinas, A. et al. 2022. Interaction testing and polygenic risk scoring to estimate the contribution of common genetic variants to treatment resistance in schizophrenia. JAMA Psychiatry 79(3), pp. 260-269. (10.1001/jamapsychiatry.2021.3799)
- Dennison, C. et al. 2021. Risk factors, clinical features, and polygenic risk scores in schizophrenia and schizoaffective disorder depressive-type. Schizophrenia Bulletin 47(5), pp. 1375-1384. (10.1093/schbul/sbab036)
- Legge, S. et al. 2021. Associations between schizophrenia polygenic liability, symptom dimensions, and cognitive ability in schizophrenia. JAMA Psychiatry 78(10), pp. 1143-1151. (10.1001/jamapsychiatry.2021.1961)
- Dennison, C. A. et al. 2021. Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank. PLoS ONE 16(3), article number: e0249189. (10.1371/journal.pone.0249189)
- Legge, S. et al. 2020. Clinical indicators of treatment-resistant psychosis. British Journal of Psychiatry 216(5), pp. 259-266. (10.1192/bjp.2019.120)
- Dennison, C. A., Legge, S. E., Pardinas, A. F. and Walters, J. T. 2020. Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective. Schizophrenia Research 217, pp. 4-12. (10.1016/j.schres.2019.10.048)
Thesis
- Dennison, C. 2021. Phenotypic and genotypic associations across the psychosis spectrum. PhD Thesis, Cardiff University.
Contact Details
Research themes
Specialisms
- Mental Health
- Depression
- Psychosis