![Matthias Eberl](https://profiles-cardiff.imgix.net/attachments/4232?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Matthias Eberl
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Matthias Eberl
Athro Imiwnoleg Drosiannol, Adran Heintiau ac Imiwnedd. Arweinydd Dinesig Byd-eang, Ysgol Feddygaeth.
Trosolwg
Rwyf bob amser wedi bod â diddordeb yn sail foleciwlaidd a chellog perthnasoedd cyd-pathogen lletyol a modiwleiddio sylfaenol ymatebion imiwnedd cymhleth.
Yn ystod fy PhD yn Giessen sefydlais ddull sgrinio i nodi antigenau celloedd CD4+ T o lyfrgelloedd cDNA y parasit Schistosoma mansoni. Yna estynnais yr astudiaethau hyn yn ystod postdoc dwy flynedd yn Efrog (DU), ac ymchwiliais i'r ymateb imiwnedd cellog a doniol i sgitsosomau ar yr haint a'r brechiad.
Mae fy ymchwil ers 2000 yn Giessen, Bern a Chaerdydd wedi canolbwyntio ar ddiffinio rôl celloedd γδ T dynol wrth bontio ymatebion imiwnedd cynhenid ac addasol.
celloedd T yw'r prototeip o lymffocytau 'anghonfensiynol' gan nad ydynt yn cael eu cyfyngu gan MHC clasurol ac yn cyfuno nodweddion celloedd T 'confensiynol', celloedd NK a chelloedd myeloid. Fel arfer dim ond poblogaeth fach mewn gwaed dynol yn unig y maent yn ei gyfansoddi, maent yn meddiannu cilfach unigryw mewn cydnabyddiaeth ficrobaidd ac yn cyfrannu at wyliadwriaeth straen ac amddiffyn rhwystrau.
Yn fwy diweddar, dechreuon ni nodweddu ymatebion imiwnedd cynnar mewn cleifion sydd wedi'u heintio'n aciwt, a diffinio llofnodion pathogen-benodol biomarcwyr cellog a hydawdd ('olion bysedd imiwnedd'), gan ddefnyddio cytometreg llif, technegau ELISA amlblecs a dulliau mathemategol.
Gosodir ein gwaith ar ryngwyneb ymchwil sylfaenol, drosiadol, cyfrifiannol a chlinigol, ac mae'n elwa'n fawr o gydweithrediadau rhyngddisgyblaethol ag imiwnolegwyr, microbiolegwyr, biocemegwyr, epidemiolegwyr, gwyddonwyr data, clinigwyr a phartneriaid masnachol.
Yn ogystal â goblygiadau ar gyfer diagnosis a thrin heintiau microbaidd, mae gan ein gwaith ganlyniadau ar gyfer dylunio brechlyn ac imiwnotherapi.
Cyhoeddiad
2026
- Eberl, M. and Pérez-Gracia, M. 2026. Bridging science and society: public engagement as a catalyst for infectious disease control and prevention [Editorial]. Immunology & Cell Biology 104 (6), pp.635-638. (10.1111/imcb.70139)
- Tyrrell, J. M. et al. 2026. Impact of a large-scale interactive and immersive science pop-up shop about infection and hygiene on visitors and volunteers. Frontiers in Public Health 14 1812530. (10.3389/fpubh.2026.1812530)
- Ogbukagu, C. M. et al., 2026. Benefits of public engagement in research and barriers to participation: A UK-based survey of academic scientists and support staff including international respondents. Immunology & Cell Biology 104 (3), pp.192-207. (10.1111/imcb.70079)
2025
- Davies, K. et al. 2025. NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus. The Journal of Immunology 214 (12), pp.3332-3344. (10.1093/jimmun/vkaf174)
- Eberl, M. et al. 2025. Supporting meaningful public involvement and engagement in health research: a call for feedback on unsuccessful grant proposals. Research Involvement and Engagement 11 145. (10.1186/s40900-025-00813-0)
- Eberl, M. et al. 2025. Microbe-responsive human γδ T cells: The peculiar case of Staphylococcus aureus. Immunology & Cell Biology 130 (10), pp.938-944. (10.1111/imcb.70060)
- Gorbenko, A. et al., 2025. Using Tsetlin Machine for decoding, visualization and minimization of local immune fingerprints in peritoneal dialysis infections. Presented at: 2025 International Symposium on the Tsetlin Machine (ISTM) Rome, Italy 8-10 October 2025. 2025 International Symposium on the Tsetlin Machine (ISTM). IEEE. , pp.132-139. (10.1109/istm67926.2025.00027)
- Emery, K. and Eberl, M. 2025. Modulation of humoral immunity by γδ T cells: a potential adjuvant strategy for vaccination. In: Murphy, K. M. and Alt, F. W. eds. Advances in Immunology. Vol. 167, Elsevier. , pp.123-173. (10.1016/bs.ai.2025.05.001)
- Eberl, M. 2025. Highlights of 2024: γδ T cells and bad blood. Immunology & Cell Biology 103 (6), pp.513-517. (10.1111/imcb.70012)
- Emery, K. et al. 2025. Enabling vaccine uptake: Strategies for the public health sector. British Journal of Hospital Medicine 86 (6), pp.1-14. (10.12968/hmed.2024.0669)
- Tarasyuk, O. et al., 2025. Prediction of the infecting organism in peritoneal dialysis patients with acute peritonitis using interpretable Tsetlin Machines. Bioinformatics Advances 5 (1) vbaf140. (10.1093/bioadv/vbaf140)
2024
- Giannoni, E. et al., 2024. Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner. European Journal of Immunology 54 (10) 2451190. (10.1002/eji.202451190)
- Burton, R. J. et al. 2024. Conventional and unconventional T cell responses contribute to the prediction of clinical outcome and causative bacterial pathogen in sepsis patients. Clinical & Experimental Immunology 216 (3), pp.293-306. (10.1093/cei/uxae019)
- Damani-Yokota, P. and Eberl, M. 2024. The γδ T Cell Club: bringing a global scientific community together in the age of Zoom. Immunology & Cell Biology 102 (5), pp.302-307. (10.1111/imcb.12742)
- Nollett, C. et al. 2024. Public involvement and engagement in scientific research and higher education: The only way is ethics?. Research Involvement and Engagement 10 (1) 50. (10.1186/s40900-024-00587-x)
- Tyrrell, J. M. et al., 2024. Combining postgraduate research training, public engagement and primary school science education - A Superbugs Master (MSc) class. Frontiers in Microbiology (10.3389/fmicb.2024.1380045)
- Leon-Lara, X. et al., 2024. γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis. Journal of Experimental Medicine 221 (7) e20231987. (10.1084/jem.20231987)
- Eberl, M. and Cruickshank, S. M. 2024. A culture shift to support public involvement and engagement in research. Journal of Experimental Medicine 221 (6) e20240268.. (10.1084/jem.20240268)
- Tyler, C. J. et al. 2024. IL-21 conditions antigen-presenting human γδ T-cells to promote IL-10 expression in naïve and memory CD4+ T-cells. Discovery Immunology (10.1093/discim/kyae008)
- Tyrrell, J. et al., 2024. Superbugs online: co-production of an educational website to increase public understanding of the microbial world in, on and around us. Frontiers in Microbiology 15 1340350. (10.3389/fmicb.2024.1340350)
2023
- Silva-Santos, B. et al., 2023. γδ T cell explorations seek terra firma. Nature Immunology 24 , pp.1606-1609. (10.1038/s41590-023-01606-x)
- Eberl, M. et al. 2023. Overcoming the disconnect between scientific research and the public. Immunology and Cell Biology 101 (7), pp.590-597. (10.1111/imcb.12657)
- Cuff, S. et al. 2023. Inflammatory biomarker signatures in post-surgical drain fluid may detect anastomotic leaks within 48 hours of colorectal resection. Techniques in Coloproctology (10.1007/s10151-023-02841-y)
- Burton, R. J. et al. 2023. GeoWaVe: Geometric median clustering with weighted voting for ensemble clustering of cytometry data. Bioinformatics 39 (1) btac751. (10.1093/bioinformatics/btac751)
2022
- Cuff, S. M. et al. 2022. Presence of ventriculoperitoneal and lumbar shunts stimulate long lasting non-inflammatory changes in the cerebrospinal fluid distinct from the response to bacterial infection. medRxiv (10.1101/2022.10.12.22280998)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Ponsford, M. J. et al. 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75 (4), pp.255-262. (10.1136/jclinpath-2020-207157)
- Tyrrell, J. M. et al., 2022. 'Superbugs': raising public awareness of antimicrobial resistance through a pop-up science shop. Research for All 6 (1), pp.1-21. (10.14324/RFA.06.1.06)
2021
- Kaminski, H. , Couzi, L. and Eberl, M. 2021. Unconventional T cells and kidney disease. Nature Reviews Nephrology 17 , pp.795-813. (10.1038/s41581-021-00466-8)
- Eberl, M. , Oldfield, E. and Herrmann, T. 2021. Editor's Note: Relates to: 'Immuno-antibiotics: targeting microbial metabolic pathways sensed by unconventional T cells'. Immunotherapy Advances 1 (1) ltab023. (10.1093/immadv/ltab023)
- Burton, R. J. et al. 2021. CytoPy: An autonomous cytometry analysis framework. PLoS Computational Biology 17 (6) e1009071. (10.1371/journal.pcbi.1009071)
- Eberl, M. , Oldfield, E. and Herrmann, T. 2021. Immuno-antibiotics: Targeting microbial metabolic pathways sensed by unconventional T cells. Immunotherapy Advances 1 (1) ltab005. (10.1093/immadv/ltab005)
2020
- Cuff, S. M. et al. 2020. Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation. Brain Communications 2 (2) fcaa218. (10.1093/braincomms/fcaa218)
- Kouzeli, A. et al. 2020. CXCL14 preferentially synergizes with homeostatic chemokine receptor systems. Frontiers in Immunology 11 561404. (10.3389/fimmu.2020.561404)
- Catar, R. A. et al., 2020. Control of neutrophil influx during peritonitis by transcriptional cross-regulation of chemokine CXCL1 by IL‐17 and IFN‐γ. Journal of Pathology 251 (2), pp.175-186. (10.1002/path.5438)
- Goodlad, C. et al., 2020. Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis. Kidney International 97 (6), pp.1253-1259. (10.1016/j.kint.2020.01.044)
- Eberl, M. 2020. Antigen recognition by human γδ T cells: one step closer to knowing. Immunology and Cell Biology 98 (5), pp.351-354. (10.1111/imcb.12334)
- Raffray, L. et al. 2020. Zoledronate rescues immunosuppressed monocytes in sepsis patients. Immunology 159 (1), pp.88-95. (10.1111/imm.13132)
2019
- Gadalla, A. A. M. et al. 2019. Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms. Scientific Reports 9 (1) 19694. (10.1038/s41598-019-55523-x)
- Nguyen, C. T. et al., 2019. γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity. Seminars in Immunopathology 41 (5), pp.595-605. (10.1007/s00281-019-00752-5)
- Burton, R. J. et al. 2019. Using artificial intelligence to reduce diagnostic workload without compromising detection of urinary tract infections. BMC Medical Informatics and Decision Making 19 (1) 171. (10.1186/s12911-019-0878-9)
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9 10136. (10.1038/s41598-019-46585-y)
- Pottanat, N. D. et al., 2019. Analysis of the Ribonuclease a superfamily of antimicrobial peptides in patients undergoing chronic peritoneal dialysis. Scientific Reports 9 , pp.-. 7753. (10.1038/s41598-019-44219-x)
2018
- Vermijlen, D. et al., 2018. γδ T cell responses: How many ligands will it take till we know?. Seminars in Cell and Developmental Biology 84 , pp.75-86. (10.1016/j.semcdb.2017.10.009)
- Chakera, A. et al., 2018. Peritonitis in Peritoneal Dialysis patients: the case for rapid diagnosis, targeted treatment and monitoring to improve outcomes. European Medical Journal Nephrology 6 , pp.56-64.
- McCarthy, N. E. and Eberl, M. 2018. Human γδ T-cell control of mucosal immunity and inflammation. Frontiers in Immunology 9 985. (10.3389/fimmu.2018.00985)
- Rhodes, D. A. et al., 2018. Regulation of human γδ T cells by BTN3A1 protein stability and ATP-binding cassette transporters. Frontiers in Immunology 9 662. (10.3389/fimmu.2018.00662)
2017
- Aufricht, C. et al., 2017. Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network. Kidney International 92 (4), pp.824-835. (10.1016/j.kint.2017.02.037)
- Chen, H. et al., 2017. Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells. Immunology and Cell Biology 95 (7), pp.620-629. (10.1038/icb.2017.21)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92 (1), pp.179-191. (10.1016/j.kint.2017.01.017)
- Howard, J. et al., 2017. The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection.. Journal of Infectious Diseases 215 (10), pp.1569-1579. (10.1093/infdis/jix149)
- Tyler, C. J. et al., 2017. Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin. The Journal of Immunology 198 (9) 1700003. (10.4049/jimmunol.1700003)
- Raby, A. et al. 2017. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology 28 (2), pp.461-478. (10.1681/ASN.2015080923)
2016
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197 (6), pp.2195-2207. (10.4049/jimmunol.1600990)
- Johansson, M. A. et al., 2016. Probiotic lactobacilli modulate staphylococcus aureus-induced activation of conventional and unconventional T cells and NK cells. Frontiers in Immunology 7 00273. (10.3389/fimmu.2016.00273)
- Morgan, M. et al. 2016. Sepsis patients with first and second-hit infections show different outcomes depending on the causative organism. Frontiers in Microbiology 7 207. (10.3389/fmicb.2016.00207)
2015
- Piggott, L. et al. 2015. Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 17 (1), pp.96. (10.1186/s13058-015-0597-9)
- Bonneville, M. et al., 2015. Chicago 2014 – 30 years of γδ T cells. Cellular Immunology 296 (1), pp.3-9. (10.1016/j.cellimm.2014.11.001)
- Rhodes, D. A. et al., 2015. Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. Journal of Immunology 194 (5), pp.2390-2398. (10.4049/jimmunol.1401064)
- Liuzzi, A. R. et al. 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36 , pp.31-37. (10.1016/j.coi.2015.06.002)
- Tyler, C. J. et al. 2015. Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system. Cellular Immunology 296 (1), pp.10-21. (10.1016/j.cellimm.2015.01.008)
2014
- Eberl, M. et al. 2014. Pathogen-specific immune fingerprints during acute infection: The diagnostic potential of human γδ T-cells. Frontiers in Immunology 5 572. (10.3389/fimmu.2014.00572)
- Khan, M. W. A. , Eberl, M. and Moser, B. 2014. Potential use of γδ T cell-based vaccines in cancer immunotherapy. Frontiers in Immunology 5 512. (10.3389/fimmu.2014.00512)
- Davey, M. S. et al., 2014. Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells. Journal of Immunology 193 (7), pp.3704-3716. (10.4049/jimmunol.1401018)
- Khan, M. W. A. et al. 2014. Expanded human blood-derived gamma delta T cells display potent antigen-presentation functions. Frontiers in Immunology 5 344. (10.3389/fimmu.2014.00344)
2013
- Welton, J. L. et al. 2013. γδ T cells predict outcome in zoledronate-treated breast cancer patients [Comment]. Oncologist 18 (8), pp.E22-E23. (10.1634/theoncologist.2013-0097)
- Lin, C. et al. 2013. Suppression of pro-inflammatory T-cell responses by human mesothelial cells. Nephrology Dialysis Transplantation 28 (7), pp.1743-1750. (10.1093/ndt/gfs612)
- Chen, H. , Dieli, F. and Eberl, M. 2013. An unconventional TRAIL to cancer therapy. European Journal of Immunology 43 (12), pp.3159-3162. (10.1002/eji.201344105)
- Lin, C. et al., 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24 (12), pp.2002-2009. (10.1681/ASN.2013040332)
- Welton, J. et al. 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28 (3), pp.464-471. (10.1002/jbmr.1797)
2012
- Bansal, R. R. et al., 2012. IL-21 enhances the potential of human gamma delta T cells to provide B-cell help. European Journal of Immunology 42 (1), pp.110-119. (10.1002/eji.201142017)
- Heuston, S. et al., 2012. HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe. Microbiology 158 (7), pp.1684-1693. (10.1099/mic.0.056069-0)
- Riganti, C. et al., 2012. Human γδ T-cell responses in infection and immunotherapy: Common mechanisms, common mediators?. European Journal of Immunology 42 (7), pp.1668-1676. (10.1002/eji.201242492)
- Silva-Santos, B. et al., 2012. gamma delta T-cell conference 2012: Close encounters for the fifth time. European Journal of Immunology 42 (12), pp.3101-3105. (10.1002/eji.201270101)
2011
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117 (6), pp.2033-2043. (10.1182/blood-2010-04-278887)
- Davey, M. S. et al. 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. Plos Pathogens 7 (5) e1002040. (10.1371/journal.ppat.1002040)
- Davey, M. S. et al. 2011. Failure to detect production of IL-10 by activated human neutrophils [Letter]. Nature Immunology 12 (11), pp.1017-1018. (10.1038/ni.2111)
- Moser, B. and Eberl, M. 2011. γδ T-APCs: a novel tool for immunotherapy? [Book Review]. Cellular and Molecular Life Sciences 68 (14), pp.2443-2452. (10.1007/s00018-011-0706-6)
- Piggott, L. et al. 2011. Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 13 (5) R88. (10.1186/bcr2945)
2010
- Brown, A. C. et al., 2010. The nonmevalonate pathway of isoprenoid biosynthesis in mycobacterium tuberculosis is essential and transcriptionally regulated by dxs. Journal of Bacteriology 192 (9), pp.2424-2433. (10.1128/JB.01402-09)
- Meraviglia, S. et al., 2010. In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Clinical and Experimental Immunology 161 (2), pp.290-297. (10.1111/j.1365-2249.2010.04167.x)
- Meuter, S. , Eberl, M. and Moser, B. 2010. Prolonged antigen survival and cytosolic export in cross-presenting human γδ T cells. Proceedings of the National Academy of Sciences of the United States of America 107 (19), pp.8730-8735. (10.1073/pnas.1002769107)
2009
- Eberl, M. and Moser, B. 2009. Monocytes and γδ T cells: close encounters in microbial infection. Trends in Immunology 30 (12), pp.562-568. (10.1016/j.it.2009.09.001)
- Eberl, M. et al. 2009. A rapid crosstalk of human gamma delta T cells and monocytes drives the acute inflammation in bacterial infections. Plos Pathogens 5 (2), pp.6-6. e1000308. (10.1371/journal.ppat.1000308)
- Brandes, M. et al., 2009. Cross-presenting human gamma delta T cells induce robust CD8(+) alpha beta T cell responses. Proceedings of the National Academy of Sciences of the United States of America 106 (7), pp.2307-2312. (10.1073/pnas.0810059106)
2007
- Dieli, F. et al., 2007. Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Research 67 (15), pp.7450-7457. (10.1158/0008-5472.can-07-0199)
- Vermijlen, D. et al., 2007. Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. The Journal of Immunology 178 (7), pp.4304-4314. (10.4049/jimmunol.178.7.4304)
- Moser, B. and Eberl, M. 2007. gammadelta T cells: novel initiators of adaptive immunity [review]. Immunological Reviews 215 (1), pp.89-102. (10.1111/j.1600-065x.2006.00472.x)
- Zafranskaya, M. et al., 2007. Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis. Immunology 121 (1), pp.29-39. (10.1111/j.1365-2567.2006.02518.x)
2006
- Eberl, M. et al. 2006. Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells. Journal of Leukocyte Biology 79 (4), pp.663-6. (10.1189/jlb.1105640)
2005
- Eberl, M. et al. 2005. Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1). Journal of leukocyte biology 77 , pp.67-70. (10.1189/jlb.0204096)
2004
- Eberl, M. et al. 2004. Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so. Infection and Immunity 72 (8), pp.4881-3. (10.1128/IAI.72.8.4881-4883.2004)
- Begley, M. et al., 2004. The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. FEBS Letters 561 (1-3), pp.99-104. (10.1016/s0014-5793(04)00131-0)
- Eberl, M. , Jomaa, H. and Hayday, A. C. 2004. Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells. Immunology 112 (3), pp.364-368. (10.1111/j.1365-2567.2004.01921.x)
2003
- Eberl, M. et al. 2003. Microbial isoprenoid biosynthesis and human gammadelta T cell activation [review]. FEBS Letters 544 (1-3), pp.4-10. (10.1016/s0014-5793(03)00483-6)
- Reichenberg, A. et al., 2003. Replacing the pyrophosphate group of HMB-PP by diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism. Biorganic and Medicinal Chemistry Letters 13 (7), pp.1257-1260. (10.1016/s0960-894x(03)00138-0)
- Eberl, M. and Jomaa, H. 2003. A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens [letter]. Trends in Immunology 24 (8), pp.407-409. (10.1016/s1471-4906(03)00170-4)
- Ostrovsky, D. N. et al., 2003. Properties of 2-C-Methyl-D-Erythritol 2,4-Cyclopyrophosphate, an intermediate in Nonmevalonate Isoprenoid Biosynthesis. Applied Biochemistry and Microbiology c/c of Prikladnaia Biokhimiia i Mikrobiologiia 39 (5), pp.497-502. (10.1023/A:1025452804046)
2002
- Kollas, A. K. et al., 2002. Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. FEBS Letters 532 (3), pp.432-436. (10.1016/s0014-5793(02)03725-0)
- Eberl, M. 2002. Don't count your interleukins before they've hatched [letter]. Trends in Immunology 23 (7), pp.341-342. (10.1016/s1471-4906(02)02239-1)
- Eberl, M. et al. 2002. A novel and sensitive method to monitor helminth infections by faecal sampling. Acta Tropica 83 (2), pp.183-187. (10.1016/s0001-706x(02)00089-x)
- Eberl, M. et al. 2002. Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology 106 (2), pp.200-211. (10.1046/j.1365-2567.2002.01414.x)
- Eberl, M. et al. 2002. Differentiation of human gamma-delta T cells towards distinct memory phenotypee. Cellular Immunology 218 (1-2), pp.1-6. (10.1016/s0008-8749(02)00519-1)
2001
- Altincicek, B. et al., 2001. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS Letters 499 (1-2), pp.37-40. (10.1016/s0014-5793(01)02516-9)
- Atincicek, B. et al., 2001. Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. The Journal of Immunology 166 (6), pp.3655-3658. (10.4049/jimmunol.166.6.3655)
- Eberl, M. et al. 2001. Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees. Infection and Immunity 69 (9), pp.5352-5362. (10.1128/iai.69.9.5352-5362.2001)
- Eberl, M. et al. 2001. Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?. Journal of Infectious Diseases 183 (8), pp.1238-1247. (10.1086/319691)
- Hintz, M. et al., 2001. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Letters 509 (2), pp.317-322. (10.1016/s0014-5793(01)03191-x)
- Kasper, G. et al., 2001. A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins. The Journal of Immunology 23 (3), pp.141-152. (10.1046/j.1365-3024.2001.00366.x)
2000
- Eberl, M. et al. 2000. IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigen. Vaccine 18 (19), pp.2002-2008. (10.1016/s0264-410x(99)00532-0)
1999
- Jomaa, H. et al., 1999. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285 (5433), pp.1573-1576. (10.1126/science.285.5433.1573)
- Eberl, M. et al. 1999. Isolation of T-cell antigens by using a recombinant protein library and its application to the identification of novel vaccine candidates against schistosomiasis. Infection and Immunity 67 (7), pp.3383-3389.
Adrannau llyfrau
- Emery, K. and Eberl, M. 2025. Modulation of humoral immunity by γδ T cells: a potential adjuvant strategy for vaccination. In: Murphy, K. M. and Alt, F. W. eds. Advances in Immunology. Vol. 167, Elsevier. , pp.123-173. (10.1016/bs.ai.2025.05.001)
Cynadleddau
- Gorbenko, A. et al., 2025. Using Tsetlin Machine for decoding, visualization and minimization of local immune fingerprints in peritoneal dialysis infections. Presented at: 2025 International Symposium on the Tsetlin Machine (ISTM) Rome, Italy 8-10 October 2025. 2025 International Symposium on the Tsetlin Machine (ISTM). IEEE. , pp.132-139. (10.1109/istm67926.2025.00027)
Erthyglau
- Eberl, M. and Pérez-Gracia, M. 2026. Bridging science and society: public engagement as a catalyst for infectious disease control and prevention [Editorial]. Immunology & Cell Biology 104 (6), pp.635-638. (10.1111/imcb.70139)
- Tyrrell, J. M. et al. 2026. Impact of a large-scale interactive and immersive science pop-up shop about infection and hygiene on visitors and volunteers. Frontiers in Public Health 14 1812530. (10.3389/fpubh.2026.1812530)
- Ogbukagu, C. M. et al., 2026. Benefits of public engagement in research and barriers to participation: A UK-based survey of academic scientists and support staff including international respondents. Immunology & Cell Biology 104 (3), pp.192-207. (10.1111/imcb.70079)
- Davies, K. et al. 2025. NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus. The Journal of Immunology 214 (12), pp.3332-3344. (10.1093/jimmun/vkaf174)
- Eberl, M. et al. 2025. Supporting meaningful public involvement and engagement in health research: a call for feedback on unsuccessful grant proposals. Research Involvement and Engagement 11 145. (10.1186/s40900-025-00813-0)
- Eberl, M. et al. 2025. Microbe-responsive human γδ T cells: The peculiar case of Staphylococcus aureus. Immunology & Cell Biology 130 (10), pp.938-944. (10.1111/imcb.70060)
- Eberl, M. 2025. Highlights of 2024: γδ T cells and bad blood. Immunology & Cell Biology 103 (6), pp.513-517. (10.1111/imcb.70012)
- Emery, K. et al. 2025. Enabling vaccine uptake: Strategies for the public health sector. British Journal of Hospital Medicine 86 (6), pp.1-14. (10.12968/hmed.2024.0669)
- Tarasyuk, O. et al., 2025. Prediction of the infecting organism in peritoneal dialysis patients with acute peritonitis using interpretable Tsetlin Machines. Bioinformatics Advances 5 (1) vbaf140. (10.1093/bioadv/vbaf140)
- Giannoni, E. et al., 2024. Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner. European Journal of Immunology 54 (10) 2451190. (10.1002/eji.202451190)
- Burton, R. J. et al. 2024. Conventional and unconventional T cell responses contribute to the prediction of clinical outcome and causative bacterial pathogen in sepsis patients. Clinical & Experimental Immunology 216 (3), pp.293-306. (10.1093/cei/uxae019)
- Damani-Yokota, P. and Eberl, M. 2024. The γδ T Cell Club: bringing a global scientific community together in the age of Zoom. Immunology & Cell Biology 102 (5), pp.302-307. (10.1111/imcb.12742)
- Nollett, C. et al. 2024. Public involvement and engagement in scientific research and higher education: The only way is ethics?. Research Involvement and Engagement 10 (1) 50. (10.1186/s40900-024-00587-x)
- Tyrrell, J. M. et al., 2024. Combining postgraduate research training, public engagement and primary school science education - A Superbugs Master (MSc) class. Frontiers in Microbiology (10.3389/fmicb.2024.1380045)
- Leon-Lara, X. et al., 2024. γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis. Journal of Experimental Medicine 221 (7) e20231987. (10.1084/jem.20231987)
- Eberl, M. and Cruickshank, S. M. 2024. A culture shift to support public involvement and engagement in research. Journal of Experimental Medicine 221 (6) e20240268.. (10.1084/jem.20240268)
- Tyler, C. J. et al. 2024. IL-21 conditions antigen-presenting human γδ T-cells to promote IL-10 expression in naïve and memory CD4+ T-cells. Discovery Immunology (10.1093/discim/kyae008)
- Tyrrell, J. et al., 2024. Superbugs online: co-production of an educational website to increase public understanding of the microbial world in, on and around us. Frontiers in Microbiology 15 1340350. (10.3389/fmicb.2024.1340350)
- Silva-Santos, B. et al., 2023. γδ T cell explorations seek terra firma. Nature Immunology 24 , pp.1606-1609. (10.1038/s41590-023-01606-x)
- Eberl, M. et al. 2023. Overcoming the disconnect between scientific research and the public. Immunology and Cell Biology 101 (7), pp.590-597. (10.1111/imcb.12657)
- Cuff, S. et al. 2023. Inflammatory biomarker signatures in post-surgical drain fluid may detect anastomotic leaks within 48 hours of colorectal resection. Techniques in Coloproctology (10.1007/s10151-023-02841-y)
- Burton, R. J. et al. 2023. GeoWaVe: Geometric median clustering with weighted voting for ensemble clustering of cytometry data. Bioinformatics 39 (1) btac751. (10.1093/bioinformatics/btac751)
- Cuff, S. M. et al. 2022. Presence of ventriculoperitoneal and lumbar shunts stimulate long lasting non-inflammatory changes in the cerebrospinal fluid distinct from the response to bacterial infection. medRxiv (10.1101/2022.10.12.22280998)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Ponsford, M. J. et al. 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75 (4), pp.255-262. (10.1136/jclinpath-2020-207157)
- Tyrrell, J. M. et al., 2022. 'Superbugs': raising public awareness of antimicrobial resistance through a pop-up science shop. Research for All 6 (1), pp.1-21. (10.14324/RFA.06.1.06)
- Kaminski, H. , Couzi, L. and Eberl, M. 2021. Unconventional T cells and kidney disease. Nature Reviews Nephrology 17 , pp.795-813. (10.1038/s41581-021-00466-8)
- Eberl, M. , Oldfield, E. and Herrmann, T. 2021. Editor's Note: Relates to: 'Immuno-antibiotics: targeting microbial metabolic pathways sensed by unconventional T cells'. Immunotherapy Advances 1 (1) ltab023. (10.1093/immadv/ltab023)
- Burton, R. J. et al. 2021. CytoPy: An autonomous cytometry analysis framework. PLoS Computational Biology 17 (6) e1009071. (10.1371/journal.pcbi.1009071)
- Eberl, M. , Oldfield, E. and Herrmann, T. 2021. Immuno-antibiotics: Targeting microbial metabolic pathways sensed by unconventional T cells. Immunotherapy Advances 1 (1) ltab005. (10.1093/immadv/ltab005)
- Cuff, S. M. et al. 2020. Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation. Brain Communications 2 (2) fcaa218. (10.1093/braincomms/fcaa218)
- Kouzeli, A. et al. 2020. CXCL14 preferentially synergizes with homeostatic chemokine receptor systems. Frontiers in Immunology 11 561404. (10.3389/fimmu.2020.561404)
- Catar, R. A. et al., 2020. Control of neutrophil influx during peritonitis by transcriptional cross-regulation of chemokine CXCL1 by IL‐17 and IFN‐γ. Journal of Pathology 251 (2), pp.175-186. (10.1002/path.5438)
- Goodlad, C. et al., 2020. Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis. Kidney International 97 (6), pp.1253-1259. (10.1016/j.kint.2020.01.044)
- Eberl, M. 2020. Antigen recognition by human γδ T cells: one step closer to knowing. Immunology and Cell Biology 98 (5), pp.351-354. (10.1111/imcb.12334)
- Raffray, L. et al. 2020. Zoledronate rescues immunosuppressed monocytes in sepsis patients. Immunology 159 (1), pp.88-95. (10.1111/imm.13132)
- Gadalla, A. A. M. et al. 2019. Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms. Scientific Reports 9 (1) 19694. (10.1038/s41598-019-55523-x)
- Nguyen, C. T. et al., 2019. γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity. Seminars in Immunopathology 41 (5), pp.595-605. (10.1007/s00281-019-00752-5)
- Burton, R. J. et al. 2019. Using artificial intelligence to reduce diagnostic workload without compromising detection of urinary tract infections. BMC Medical Informatics and Decision Making 19 (1) 171. (10.1186/s12911-019-0878-9)
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9 10136. (10.1038/s41598-019-46585-y)
- Pottanat, N. D. et al., 2019. Analysis of the Ribonuclease a superfamily of antimicrobial peptides in patients undergoing chronic peritoneal dialysis. Scientific Reports 9 , pp.-. 7753. (10.1038/s41598-019-44219-x)
- Vermijlen, D. et al., 2018. γδ T cell responses: How many ligands will it take till we know?. Seminars in Cell and Developmental Biology 84 , pp.75-86. (10.1016/j.semcdb.2017.10.009)
- Chakera, A. et al., 2018. Peritonitis in Peritoneal Dialysis patients: the case for rapid diagnosis, targeted treatment and monitoring to improve outcomes. European Medical Journal Nephrology 6 , pp.56-64.
- McCarthy, N. E. and Eberl, M. 2018. Human γδ T-cell control of mucosal immunity and inflammation. Frontiers in Immunology 9 985. (10.3389/fimmu.2018.00985)
- Rhodes, D. A. et al., 2018. Regulation of human γδ T cells by BTN3A1 protein stability and ATP-binding cassette transporters. Frontiers in Immunology 9 662. (10.3389/fimmu.2018.00662)
- Aufricht, C. et al., 2017. Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network. Kidney International 92 (4), pp.824-835. (10.1016/j.kint.2017.02.037)
- Chen, H. et al., 2017. Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells. Immunology and Cell Biology 95 (7), pp.620-629. (10.1038/icb.2017.21)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92 (1), pp.179-191. (10.1016/j.kint.2017.01.017)
- Howard, J. et al., 2017. The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection.. Journal of Infectious Diseases 215 (10), pp.1569-1579. (10.1093/infdis/jix149)
- Tyler, C. J. et al., 2017. Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin. The Journal of Immunology 198 (9) 1700003. (10.4049/jimmunol.1700003)
- Raby, A. et al. 2017. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology 28 (2), pp.461-478. (10.1681/ASN.2015080923)
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197 (6), pp.2195-2207. (10.4049/jimmunol.1600990)
- Johansson, M. A. et al., 2016. Probiotic lactobacilli modulate staphylococcus aureus-induced activation of conventional and unconventional T cells and NK cells. Frontiers in Immunology 7 00273. (10.3389/fimmu.2016.00273)
- Morgan, M. et al. 2016. Sepsis patients with first and second-hit infections show different outcomes depending on the causative organism. Frontiers in Microbiology 7 207. (10.3389/fmicb.2016.00207)
- Piggott, L. et al. 2015. Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 17 (1), pp.96. (10.1186/s13058-015-0597-9)
- Bonneville, M. et al., 2015. Chicago 2014 – 30 years of γδ T cells. Cellular Immunology 296 (1), pp.3-9. (10.1016/j.cellimm.2014.11.001)
- Rhodes, D. A. et al., 2015. Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. Journal of Immunology 194 (5), pp.2390-2398. (10.4049/jimmunol.1401064)
- Liuzzi, A. R. et al. 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36 , pp.31-37. (10.1016/j.coi.2015.06.002)
- Tyler, C. J. et al. 2015. Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system. Cellular Immunology 296 (1), pp.10-21. (10.1016/j.cellimm.2015.01.008)
- Eberl, M. et al. 2014. Pathogen-specific immune fingerprints during acute infection: The diagnostic potential of human γδ T-cells. Frontiers in Immunology 5 572. (10.3389/fimmu.2014.00572)
- Khan, M. W. A. , Eberl, M. and Moser, B. 2014. Potential use of γδ T cell-based vaccines in cancer immunotherapy. Frontiers in Immunology 5 512. (10.3389/fimmu.2014.00512)
- Davey, M. S. et al., 2014. Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells. Journal of Immunology 193 (7), pp.3704-3716. (10.4049/jimmunol.1401018)
- Khan, M. W. A. et al. 2014. Expanded human blood-derived gamma delta T cells display potent antigen-presentation functions. Frontiers in Immunology 5 344. (10.3389/fimmu.2014.00344)
- Welton, J. L. et al. 2013. γδ T cells predict outcome in zoledronate-treated breast cancer patients [Comment]. Oncologist 18 (8), pp.E22-E23. (10.1634/theoncologist.2013-0097)
- Lin, C. et al. 2013. Suppression of pro-inflammatory T-cell responses by human mesothelial cells. Nephrology Dialysis Transplantation 28 (7), pp.1743-1750. (10.1093/ndt/gfs612)
- Chen, H. , Dieli, F. and Eberl, M. 2013. An unconventional TRAIL to cancer therapy. European Journal of Immunology 43 (12), pp.3159-3162. (10.1002/eji.201344105)
- Lin, C. et al., 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24 (12), pp.2002-2009. (10.1681/ASN.2013040332)
- Welton, J. et al. 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28 (3), pp.464-471. (10.1002/jbmr.1797)
- Bansal, R. R. et al., 2012. IL-21 enhances the potential of human gamma delta T cells to provide B-cell help. European Journal of Immunology 42 (1), pp.110-119. (10.1002/eji.201142017)
- Heuston, S. et al., 2012. HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe. Microbiology 158 (7), pp.1684-1693. (10.1099/mic.0.056069-0)
- Riganti, C. et al., 2012. Human γδ T-cell responses in infection and immunotherapy: Common mechanisms, common mediators?. European Journal of Immunology 42 (7), pp.1668-1676. (10.1002/eji.201242492)
- Silva-Santos, B. et al., 2012. gamma delta T-cell conference 2012: Close encounters for the fifth time. European Journal of Immunology 42 (12), pp.3101-3105. (10.1002/eji.201270101)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117 (6), pp.2033-2043. (10.1182/blood-2010-04-278887)
- Davey, M. S. et al. 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. Plos Pathogens 7 (5) e1002040. (10.1371/journal.ppat.1002040)
- Davey, M. S. et al. 2011. Failure to detect production of IL-10 by activated human neutrophils [Letter]. Nature Immunology 12 (11), pp.1017-1018. (10.1038/ni.2111)
- Moser, B. and Eberl, M. 2011. γδ T-APCs: a novel tool for immunotherapy? [Book Review]. Cellular and Molecular Life Sciences 68 (14), pp.2443-2452. (10.1007/s00018-011-0706-6)
- Piggott, L. et al. 2011. Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 13 (5) R88. (10.1186/bcr2945)
- Brown, A. C. et al., 2010. The nonmevalonate pathway of isoprenoid biosynthesis in mycobacterium tuberculosis is essential and transcriptionally regulated by dxs. Journal of Bacteriology 192 (9), pp.2424-2433. (10.1128/JB.01402-09)
- Meraviglia, S. et al., 2010. In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Clinical and Experimental Immunology 161 (2), pp.290-297. (10.1111/j.1365-2249.2010.04167.x)
- Meuter, S. , Eberl, M. and Moser, B. 2010. Prolonged antigen survival and cytosolic export in cross-presenting human γδ T cells. Proceedings of the National Academy of Sciences of the United States of America 107 (19), pp.8730-8735. (10.1073/pnas.1002769107)
- Eberl, M. and Moser, B. 2009. Monocytes and γδ T cells: close encounters in microbial infection. Trends in Immunology 30 (12), pp.562-568. (10.1016/j.it.2009.09.001)
- Eberl, M. et al. 2009. A rapid crosstalk of human gamma delta T cells and monocytes drives the acute inflammation in bacterial infections. Plos Pathogens 5 (2), pp.6-6. e1000308. (10.1371/journal.ppat.1000308)
- Brandes, M. et al., 2009. Cross-presenting human gamma delta T cells induce robust CD8(+) alpha beta T cell responses. Proceedings of the National Academy of Sciences of the United States of America 106 (7), pp.2307-2312. (10.1073/pnas.0810059106)
- Dieli, F. et al., 2007. Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Research 67 (15), pp.7450-7457. (10.1158/0008-5472.can-07-0199)
- Vermijlen, D. et al., 2007. Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. The Journal of Immunology 178 (7), pp.4304-4314. (10.4049/jimmunol.178.7.4304)
- Moser, B. and Eberl, M. 2007. gammadelta T cells: novel initiators of adaptive immunity [review]. Immunological Reviews 215 (1), pp.89-102. (10.1111/j.1600-065x.2006.00472.x)
- Zafranskaya, M. et al., 2007. Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis. Immunology 121 (1), pp.29-39. (10.1111/j.1365-2567.2006.02518.x)
- Eberl, M. et al. 2006. Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells. Journal of Leukocyte Biology 79 (4), pp.663-6. (10.1189/jlb.1105640)
- Eberl, M. et al. 2005. Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1). Journal of leukocyte biology 77 , pp.67-70. (10.1189/jlb.0204096)
- Eberl, M. et al. 2004. Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so. Infection and Immunity 72 (8), pp.4881-3. (10.1128/IAI.72.8.4881-4883.2004)
- Begley, M. et al., 2004. The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. FEBS Letters 561 (1-3), pp.99-104. (10.1016/s0014-5793(04)00131-0)
- Eberl, M. , Jomaa, H. and Hayday, A. C. 2004. Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells. Immunology 112 (3), pp.364-368. (10.1111/j.1365-2567.2004.01921.x)
- Eberl, M. et al. 2003. Microbial isoprenoid biosynthesis and human gammadelta T cell activation [review]. FEBS Letters 544 (1-3), pp.4-10. (10.1016/s0014-5793(03)00483-6)
- Reichenberg, A. et al., 2003. Replacing the pyrophosphate group of HMB-PP by diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism. Biorganic and Medicinal Chemistry Letters 13 (7), pp.1257-1260. (10.1016/s0960-894x(03)00138-0)
- Eberl, M. and Jomaa, H. 2003. A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens [letter]. Trends in Immunology 24 (8), pp.407-409. (10.1016/s1471-4906(03)00170-4)
- Ostrovsky, D. N. et al., 2003. Properties of 2-C-Methyl-D-Erythritol 2,4-Cyclopyrophosphate, an intermediate in Nonmevalonate Isoprenoid Biosynthesis. Applied Biochemistry and Microbiology c/c of Prikladnaia Biokhimiia i Mikrobiologiia 39 (5), pp.497-502. (10.1023/A:1025452804046)
- Kollas, A. K. et al., 2002. Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. FEBS Letters 532 (3), pp.432-436. (10.1016/s0014-5793(02)03725-0)
- Eberl, M. 2002. Don't count your interleukins before they've hatched [letter]. Trends in Immunology 23 (7), pp.341-342. (10.1016/s1471-4906(02)02239-1)
- Eberl, M. et al. 2002. A novel and sensitive method to monitor helminth infections by faecal sampling. Acta Tropica 83 (2), pp.183-187. (10.1016/s0001-706x(02)00089-x)
- Eberl, M. et al. 2002. Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology 106 (2), pp.200-211. (10.1046/j.1365-2567.2002.01414.x)
- Eberl, M. et al. 2002. Differentiation of human gamma-delta T cells towards distinct memory phenotypee. Cellular Immunology 218 (1-2), pp.1-6. (10.1016/s0008-8749(02)00519-1)
- Altincicek, B. et al., 2001. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS Letters 499 (1-2), pp.37-40. (10.1016/s0014-5793(01)02516-9)
- Atincicek, B. et al., 2001. Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. The Journal of Immunology 166 (6), pp.3655-3658. (10.4049/jimmunol.166.6.3655)
- Eberl, M. et al. 2001. Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees. Infection and Immunity 69 (9), pp.5352-5362. (10.1128/iai.69.9.5352-5362.2001)
- Eberl, M. et al. 2001. Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?. Journal of Infectious Diseases 183 (8), pp.1238-1247. (10.1086/319691)
- Hintz, M. et al., 2001. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Letters 509 (2), pp.317-322. (10.1016/s0014-5793(01)03191-x)
- Kasper, G. et al., 2001. A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins. The Journal of Immunology 23 (3), pp.141-152. (10.1046/j.1365-3024.2001.00366.x)
- Eberl, M. et al. 2000. IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigen. Vaccine 18 (19), pp.2002-2008. (10.1016/s0264-410x(99)00532-0)
- Jomaa, H. et al., 1999. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285 (5433), pp.1573-1576. (10.1126/science.285.5433.1573)
- Eberl, M. et al. 1999. Isolation of T-cell antigens by using a recombinant protein library and its application to the identification of novel vaccine candidates against schistosomiasis. Infection and Immunity 67 (7), pp.3383-3389.
Ymchwil
Olion bysedd imiwnedd mewn haint acíwt
Mae diagnosio, trin ac atal haint yn wyneb lledaeniad byd-eang o ymwrthedd gwrthficrobaidd a risg gyson o bandemig dinistriol yn un o heriau mwyaf yr 21ain ganrif. Fodd bynnag, mae diffyg gwerthfawrogiad o hyd o sut mae'r corff yn synhwyro ac yn ymladd gwahanol fathau o pathogenau.
Nod ein hymchwil yw archwilio a manteisio ar y digwyddiadau pathoffisiolegol sy'n sail i ymatebion llidiol pathogen-benodol at ddibenion diagnostig a therapiwtig. Mae'r system imiwnedd wedi esblygu i arolygu'r corff yn gyson am strwythurau a allai fod yn beryglus. Mae gwahanol pathogenau yn mynegi gwahanol batrymau moleciwlaidd ac felly'n rhyngweithio'n unigryw â chydrannau gwahanol o'r system imiwnedd. Felly, mae'r math o haint yn debygol o ennyn llofnodion imiwnolegol gwahanol, neu 'olion bysedd imiwnedd', y gellir eu hasesu'n feintiol ac yn ansoddol.
Enghraifft wych o'r gwahaniaethu hwn o wahanol pathogenau yw ymateboldeb unigryw celloedd T anghonfensiynol i metabolion microbaidd cyffredin sy'n cael eu rhannu gan lawer o pathogenau bacteriol ond sy'n absennol o gelloedd dynol. Mae celloedd γδ T a chelloedd MAIT yn cael eu tynnu'n gyflym i safleoedd haint acíwt, lle byddant yn dod ar draws microbau goresgynnol yng nghyd-destun celloedd imiwnedd eraill, niwtroffilau a monocytau yn bennaf, a'r meinwe amgylchynol.
Mae ein canfyddiadau'n dangos y bydd y rhyngweithio hwn yn denu celloedd effaith pellach, yn gwella gweithgaredd celloedd scavenger ac yn hyrwyddo datblygiad imiwnedd microb-benodol. Fodd bynnag, os caiff ei sbarduno ar yr adeg anghywir neu'r safle anghywir, gall yr adwaith hwn arwain at ddifrod sy'n gysylltiedig â llid ac effeithio ar ganlyniadau cleifion. Mae'r celloedd T anghonfensiynol canol cam yn trefnu rhaeadrau llidiol mewn heintiau microbaidd yn nodi'r celloedd hyn fel prif dargedau ar gyfer triniaethau a diagnosteg newydd.
Rydym yn anelu at ddiffinio llofnodion pathogen-benodol lleol a systemig o fiomarcwyr imiwnedd hydawdd a chellog mewn clefydau lle mae ymyrraeth gynnar a thargedu yn allweddol a lle bydd canlyniadau clinigol yn elwa o ddiagnosteg well a chynharach. Ar gyfer hyn, rydym yn astudio unigolion sy'n cyflwyno cyflyrau acíwt fel peritonitis, sepsis difrifol, haint y llwybr wrinol a ventriculitis, mewn cydweithrediadau â chlinigwyr, microbiolegwyr, ystadegwyr, gwyddonwyr cyfrifiadurol a phartneriaid masnachol.
Aelodau presennol a gorffennol y grŵp
- Kirsty Emery, Myfyrwraig PhD 2023–
- Jennifer Waterman, Myfyrwraig PhD 2024–
- Siva Oruganti, Myfyriwr PhD 2024–
- Kate Davies, Myfyrwraig PhD (cyd-oruchwylydd) 2022–
- Nikos Tteralli, Myfyriwr MD (cyd-oruchwylydd) 2025-
- Gervas Gibuyi, Myfyriwr MPH (cyd-oruchwylydd) 2026
- Aparna Ajithkumar, Uwch Dechnegydd 2026
- Jonathan Varghese, Hyfforddai SFP1 2026-2027
- Helan Ahmad, Hyfforddai SFP2 2026-2027
- Mia-Lily Hobdey, Myfyriwr Interniaeth 2026–
- Raya Ahmed, Ôl-ddoethuriaeth 2016-2019
- Sarah Baker, Cynorthwy-ydd Ymchwil 2018-2021
- Josephine Banda, Myfyrwraig MSc (cyd-oruchwylydd) 2023
- Raj Bansal, Myfyriwr PhD 2007-2012
- Aaron Bolitho, Uwch Dechnegydd 2024-2025
- Amy Brook, Myfyrwraig PhD 2015-2019
- Ross Burton, Myfyriwr PhD 2018-2022
- Hung-Chang Chen, Myfyriwr PhD 2011-2016
- Chantal Colmont, Cynorthwy-ydd Ymchwil 2013-2014
- Dydd Gwener Cox, Myfyriwr Interniaeth 2024
- Simone Cuff, Ôl-ddoethuriaeth 2017-2022
- Martin Davey, Myfyriwr PhD/Ôl-ddoethurol 2008-2013
- Kashia Dias, Myfyriwr Interniaeth 2024
- Nicholas Graves, Hyfforddai SFP2 2024-2025
- Daniel Griffiths, Myfyriwr MPhil 2023-2025
- Ida Jackson (Friberg), Ôl-ddoethuriaeth 2013-2015
- Emily Jacob, Myfyriwr MPhil (cyd-oruchwylydd) 2020-2022
- Maximilian Keisker, Myfyriwr Erasmus 2017
- Ariadni Kouzeli, Myfyriwr PhD (cyd-oruchwylydd) 2015-2020
- Ann Kift-Morgan, Cynorthwy-ydd Ymchwil 2011-2018
- Jack Leyshon, Uwch Dechnegydd 2024
- Chan-Yu Lin, Myfyriwr PhD 2009-2012
- Anna Rita Liuzzi, myfyrwraig PhD/Ôl-ddoethurol 2013-2016
- Christophe Macri, Myfyriwr Interniaeth 2009
- Lila-blythe Maros, Myfyriwr Interniaeth 2025
- Salvador Martí Pérez, Ôl-ddoethuriaeth 2009-2010
- Oliwia Michalak, Myfyriwr PhD 2018-2020
- Linda Moet, Myfyriwr PhD (cyd-oruchwylydd) 2018-2022
- Matt Morgan, Myfyriwr PhD (cyd-oruchwylydd) 2011-2014
- Luke Piggott, Myfyriwr PhD (cyd-oruchwylydd) 2009-2012
- Emily Pockett, Myfyrwraig MSc 2025
- Loic Raffray, Cymrawd Marie Curie yr UE 2017-2018
- Nicola Reeves, Myfyriwr MD (cyd-oruchwylydd) 2019-2021
- Al-Motaz Rizek, Myfyriwr MSc (cyd-oruchwylydd) 2024
- Teja Rus, Myfyriwr PhD (cyd-oruchwylydd) 2015-2020
- Michele Scotto di Mase, Myfyriwr Interniaeth 2015
- Yasmin Shanneik, Myfyriwr Erasmus 2014-2015
- Lucy Sheikh, Myfyrwraig MSc (cyd-oruchwyliwr) 2023
- Georgina Sparling, Myfyriwr Interniaeth 2025
- Katie Stanswood, Myfyrwraig MSc (cyd-oruchwylydd) 2022
- Chris Tyler, Myfyriwr PhD 2012-2016
- Joanne Welton, Ôl-ddoethuriaeth 2011-2013
- Jingjing Zhang, Ôl-ddoethuriaeth 2015-2016
Cymorth grant
2026-2027
Rhaglen Hyfforddiant Academaidd Addysg a Gwella Iechyd Cymru, prosiect Rhaglen Sylfaen Arbenigol 2 (SFP2) (i Helan Ahmad)
"Rhagfynegiad gollyngiadau anastomotig mewn cleifion sy'n cael resection colorectal confensiynol yn erbyn robotig"
Prif Ymgeisydd (cyd-ymgeiswyr: Jennifer Waterman, Dr. Simone Cuff)
2025
MSc mewn Imiwnoleg Arbrofol a Chlinigol Gymhwysol, Prifysgol Caerdydd (i Emily Pockett)
"Modiwleiddio celloedd T γδ dynol gan cytocinau llidiol a rheoleiddio"
Prif oruchwyliwr (gyda Dr. James McLaren, Kirsty Emery)
£ 3,500
2024-2026
Cymdeithas Llawfeddygon Prydain Fawr, ASGBI a Gwobr Ymchwil Llawfeddygol GUTS UK
"Canfod gollyngiadau anastomotig yn gynnar ar ôl llawdriniaeth a'r rhefr gan ddefnyddio biofarcwyr hylif peritoneal sy'n hydawdd ac nad ydynt yn hydawdd"
Cyd-ymgeisydd (Prif ymgeisydd: Jennifer Waterman; cyd-ymgeiswyr Yr Athro Jared Torkington, Dr. Nicola Reeves, Dr. Natalie Joseph-Williams)
£ 10,000
2024-2025
Rhaglen Hyfforddiant Academaidd Addysg a Gwella Iechyd Cymru, prosiect Rhaglen Sylfaen Arbenigol 2 (SFP2) (i Nick Graves)
"Rhagfynegi gollyngiadau anastomotig mewn cleifion ar ôl llawdriniaeth colorectol"
Prif Ymgeisydd (cyd-ymgeisydd: Dr. Nicola Reeves)
2023-2026
Ymchwil Iechyd a Gofal Cymru, Grant Ymchwil Iechyd
"Canfod gollyngiad anastomotig yn gynnar ar ôl llawdriniaeth colorectol"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Jared Torkington, Dr. Nicola Reeves, Dr. Natalie Joseph-Williams, Dr. Rachel Morris, Dr. Susan Campbell)
£ 145,684
2023-2027
Ysgoloriaeth PhD GW4 MRC DTP (i Kirsty Emery)
"Rheoli imiwnedd mwcosaidd ac uniondeb coluddyn gan gelloedd T γδ dynol" (48 mis)
Prif Ymgeisydd (cyd-ymgeiswyr: Dr. Neil McCarthy, Dr. Gareth Jones)
tua £ 100,000
2023-2026
Ysgoloriaeth PhD Hwb Ymchwil Canser Prifysgol Caerdydd (i Daniel Griffiths)
"Offer newydd ar gyfer dadansoddi data cytometreg dimensiwn uchel – goblygiadau ar gyfer imiwnoleg canser ac imiwnotherapi"
Prif Ymgeisydd (cyd-ymgeiswyr: Dr. Andreas Artemiou, Yr Athro Awen Gallimore)
£ 81,728
2022-2026
Ysgoloriaeth PhD GW4 MRC DTP (i Kate Davies)
"Atal imiwnedd celloedd T a chynhyrchu gwrthgyrff yn ystod haint firws a sepsis"
Cyd-ymgeisydd (Prif ymgeisydd: Dr. James McLaren; cyd-ymgeisydd: Dr. Gareth Jones)
tua £ 100,000
2022
Rhaglen Sbrint Llywodraeth Cymru
"Diagnosis a prognosis sepsis ôl-lawdriniaeth dan arweiniad deallusrwydd artiffisial"
Prif Ymgeisydd
2021-2022
Ymchwil Iechyd a Gofal Cymru, Grant Ymchwil Iechyd
"Epidemioleg ac effaith heintiau eilaidd bacteriol ac ymwrthedd gwrthficrobaidd ar Ofal Dwys yn ystod pandemig SARS-CoV-2"
Cyd-ymgeisydd (Prif ymgeisydd: Dr. Lim Jones; gyda Dr. Mandy Wootton, Dr. James McLaren, Yr Athro Thomas Connor, Dr. Matt Morgan, Dr. Matt Wise, Dr. Harriet Hughes, Dr. Brendan Healey, Dr. Brad Spiller)
£ 74,000
2021
Gwobr Partneriaeth Drosiadol Sefydliadol Ymddiriedolaeth Wellcome (ITPA)
"Diagnosis a prognosis seiliedig ar feddyginiaeth fanwl o sepsis ôl-lawdriniaeth"
Prif Ymgeisydd (gyda'r Athro Jared Torkington, Dr. Nicola Reeves, Dr. Matt Morgan, Dr. Andreas Artemiou, Dr. Simone Cuff, Ross Burton)
£19,969
2019-2021
Prosiect CYFLYMU
"Diagnosis meddygaeth fanwl o gymhlethdodau ôl-lawfeddygol mewn claf sy'n cael llawdriniaeth yn yr abdomen"
Prif Ymgeisydd (gyda'r Athro Ian Weeks, yr Athro Jared Torkington, Dr. Rachel Morris)
£ 468,913
2019-2020
Gwobr Trawsddisgyblaethol ISSF3 Ymddiriedolaeth Wellcome
"Canfod haint niwrolegol sy'n peryglu bywyd yn gyflym trwy ganfod olion bysedd imiwnedd mewn hylif cerebrospinal"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro William Gray, Dr. Andreas Artemiou, Dr. Simone Cuff, Mr. Joseph Merola)
£ 49,996
2018-2021
Cymrodoriaeth Meddygaeth Manwl Cronfa Datblygu Rhanbarthol Ewrop Sêr Cymru II (i Dr. Tom Pembroke)
"Imiwnedd olion bysedd heintiau bacteriol mewn sirosis"
Cyd-ymgeisydd (gyda'r Athro Andrew Godkin)
£ 185,000
2018-2022
Ysgoloriaeth PhD GW4 DTP (i Oliwia Michalak)
"Dysgu peirianyddol dan arweiniad olion bysedd imiwnedd ar gyfer canfod haint sy'n peryglu bywyd yn gyflym mewn sirosis yr afu
Prif Ymgeisydd (cyd-ymgeiswyr: Dr. Tom Pembroke, Dr. Andreas Artemiou):
tua £ 80,000
2018-2021
Ysgol Meddygaeth PhD Ysgoloriaeth (i Ross Burton)
"Olion bysedd imiwnedd systemig mewn cleifion â sepsis difrifol acíwt"
Prif Ymgeisydd (cyd-ymgeiswyr: Dr. Andreas Artemiou, Dr. Matt Morgan, Yr Athro Peter Ghazal):
tua £ 60,000
2018
Gwobr Trawsddisgyblaethol ISSF3 Ymddiriedolaeth Wellcome
"Immune fingerprints in haemodialysis patients with acute infection"
Prif Ymgeisydd (gyda Dr. Soma Meran, Dr. Matt Morgan, Dr. Simone Cuff, Dr. Andreas Artemiou, Yr Athro Donald Fraser)
£ 49,955
2017-2018
Horizon 2020 yr UE, Cymrodoriaeth Unigol Marie Skłodowska-Curie (i Dr. Loic Raffray)
"Celloedd T cynhenid mewn sepsis (ILTIS): Goblygiadau ar gyfer diagnosis cynnar ac achub atal imiwnedd"
Prif oruchwyliwr (cyd-oruchwyliwr Dr. Matt Morgan)
UE € 97,727
2017
Cynllun Agosrwydd at Ddarganfod MRC (Catalydd Biofeddygol)
"Canfod a nodweddu heintiau niwrolegol sy'n peryglu bywyd yn gyflym"
Cyd-ymgeisydd (Ymgeisydd arweiniol: Yr Athro Ian Weeks; cyd-ymgeisydd: Yr Athro William Gray)
£ 24,161
2017
Cronfa Bontio Gwyddorau Bywyd Cymru, Grant Pathfinder
"Datblygu profion diagnostig cyflym in vitro ar gyfer canfod a nodweddu haint yn gynnar"
Cyd-ymgeisydd (Ymgeisydd arweiniol: Yr Athro Ian Weeks; cyd-ymgeiswyr: Yr Athro Nicholas Topley, Dr. Fraser Logue)
£ 74,554
2016-2019
Grant ymchwil MRC
"Synhwyro pathogen cynhenid gan gelloedd T anghonfensiynol lleol yn ystod heintiau microbaidd"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Donald Fraser, Yr Athro David Price, Dr. Kristin Ladell, Yr Athro Phil Taylor, Yr Athro Jamie Rossjohn)
£ 660,663
2016-2019
Ymchwil Iechyd a Gofal Cymru, Gwobr Amser Ymchwil Glinigol (i Dr. Matt Morgan)
Goruchwyliwr Academaidd
£ 66,535
2016
Gwobr Seedcorn ISSF Ymddiriedolaeth Wellcome
"Polareiddio cyfryngol celloedd T γδ o ymatebion celloedd T CD4+ : goblygiadau ar gyfer clefyd Crohn"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Bernhard Moser, Dr. Andrew Stagg, Dr. James Lindsay)
£ 34,000
2016
Cymrodoriaeth Ymweld Derbyn Caerdydd (i'r Athro Thomas Herrmann)
Prif Ymgeisydd
£ 5,500
2015-2018
Ysgoloriaeth PhD MRC (i Amy Brook)
"Llofnodion microRNA pathogen-benodol yn ystod haint peritoneal acíwt"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Donald Fraser, Dr. Timothy Bowen)
£ 60,000
2015-2018
Ysgoloriaeth PhD MRC (i Ariadni Kouzeli)
"Defnyddio gama / delta T-APCs dynol mewn imiwnedd gwrth-tiwmor"
Cyd-ymgeisydd (Prif ymgeisydd: Yr Athro Bernhard Moser; cyd-ymgeisydd: Yr Athro Andrew Godkin)
£ 60,000
2015-2018
Ysgoloriaeth PhD Tenovus (i Teja Rust)
"T-APCs gama / delta dynol: Prosesu antigenau tiwmor ac ymsefydlu imiwnedd gwrth-tiwmor"
Cyd-ymgeisydd (Prif ymgeisydd: Yr Athro Bernhard Moser; cyd-ymgeisydd: Yr Athro Awen Gallimore)
£ 89,780
2015-2018
Ymchwil Iechyd a Gofal Cymru, grant prosiect Canolfan Ymchwil Canser Cymru
"Modelau cyn-glinigol ar gyfer imiwnotherapïau newydd"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Awen Gallimore, Yr Athro Bernhard Moser, Yr Athro Andrew Godkin, Dr. Ann Ager)
£ 110,000
2015-2020
Ymchwil Iechyd a Gofal Cymru
"Uned Ymchwil Arennau Cymru"
Cyd-ymgeisydd (Prif Ymgeisydd: Yr Athro Donald Fraser; gyda chyd-ymgeiswyr ar draws Caerdydd, Casnewydd, Abertawe a Bangor)
£ 2,000,000
2015-2016
Kidney Research UK, Grant Prosiect
"Canfod haint yn gyflym a gwella goroesiad mewn cleifion dialysis: rôl ymatebion llidiol a yrrir gan gelloedd T anghonfensiynol"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Nicholas Topley, Yr Athro Bernhard Moser, Dr. Kieron Donovan, Yr Athro Donald Fraser)
£ 199,218
2014-2015
MRC-Cynllun Hyder mewn Cysyniad (Catalydd Biofeddygol)
"Diagnosis pwynt gofal o sepsis acíwt"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Nicholas Topley, Yr Athro Paul Davis, Dr. Peter Morgan, Dr. Tamas Szakmany, Dr. Matt Morgan)
£ 44,935
2014
Cynghrair Ymchwil Drosiadol Glannau Hafren (SARTRE), Gwobr Prosiect Her Technoleg Iechyd
"Diagnosis pwynt gofal o heintiau llif gwaed"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Nicholas Topley, Yr Athro Judith Hall, Yr Athro Paul Davis)
£ 24,912
2013-2016
Rhwydwaith Hyfforddiant Cychwynnol Marie Curie FP7 yr UE, ITN 287813
"Hyfforddiant ac Ymchwil Ewropeaidd mewn Dialysis Peritoneal (EuTRiPD)"
Goruchwyliwr PhD (mewn cydweithrediad â chanolfannau academaidd yn Amsterdam, Berlin, Caerdydd, Heidelberg, Madrid, Poznan, Strasbwrg, Fienna; partneriaid diwydiannol: Zytoprotect, Baxter, Abbott; a Sefydliad Arennau yr Iseldiroedd, Kidney Research UK, EuroPD)
EU € 3,140,988 i gyd; € 517,568 ohono i Brifysgol Caerdydd
2013-2016
Dyfarniad Datblygu Cynnyrch Cam Cynnar NIHR Dyfeisio ar gyfer Arloesi (i4i)
"Profion cyflym, anfewnwthiol ar gyfer heintiau bacteriol acíwt yn seiliedig ar olion bysedd imiwnedd pathogen penodol"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Nicholas Topley, Yr Athro Ian Weeks, Yr Athro Chris Butler, Dr. Eryl Cox, Yr Athro Paul Davis)
£ 421,961
2013-2014
NISCHR/Wellcome Trust ISSF Seedcorn/Grant Dichonoldeb
"Diffinio ymatebion pathogen-benodol mewn haint acíwt: datblygu profion pwynt gofal ar gyfer adnabod bacteriol"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Nicholas Topley, Dr. Kieron Donovan, Dr. Julian Marchesi, Dr. James Chess)
£ 49,972
2013
Galwad Offer Cydweithredu Gwyddor Iechyd Academaidd NISCHR
Cyd-ymgeisydd (prif ymgeisydd: Dr. Kieron Donovan)
£ 5,000
2013
Cancer Research UK, Cronfa Datblygu Canolfan CR-UK Caerdydd
"Goresgyn ymwrthedd bôn-gelloedd canser y fron i imiwnotherapïau newydd"
Prif Ymgeisydd (cyd-ymgeiswyr: Dr. Richard Clarkson, Hung-Chang Chen)
£ 4,950
2012-2015
Ysgoloriaeth PhD MRC (i Chris Tyler)
"Rheoli ymatebion celloedd T alffa / beta gan T-APCs gama / delta dynol"
Prif Ymgeisydd (cyd-ymgeisydd: Yr Athro Bernhard Moser)
£ 60,000
2011-2015
Ysgoloriaeth PhD Tenovus (i Hung-Chang Chen)
"Celloedd T gama / delta dynol ar gyfer imiwnotherapi canser y fron"
Prif Ymgeisydd (cyd-ymgeisydd: Dr. Richard Clarkson)
£ 89,993
2010-2013
Llywodraeth Cynulliad Cymru, Gwobr Ymchwil Iechyd
"Gwella canlyniadau cleifion o heintiau sy'n gysylltiedig â dialysis peritoneal"
Prif gyd-ymgeisydd (Prif ymgeisydd: Dr. Gareth Roberts; cyd-ymgeiswyr: Yr Athro Nicholas Topley, Yr Athro Aled Phillips)
£ 207,325
2010
Ymddiriedolaeth Wellcome, Ysgoloriaeth Gwyliau Biofeddygol (i Sarah Rollason)
"celloedd T gama / delta ar gyfer imiwnotherapi canser"
Prif ymgeisydd
£ 1,080
2010
Cancer Research UK, Cronfa Datblygu Canolfan CR-UK Caerdydd
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Malcolm Mason, Yr Athro Peter Barrett-Lee)
£ 4,940
2009-2013
Gofal Iechyd Baxter, Grant All-murlun Darganfyddiadau Arennol
"Celloedd T, monocytes a niwtroffiliau: croessiarad niweidiol mewn haint sy'n gysylltiedig â dialysis peritoneal"
Prif Ymgeisydd (cyd-ymgeisydd: Yr Athro John D. Williams)
US $ 374,947
2009-2012
Cancer Research UK, Grant Prosiect
"Plastigrwydd swyddogaethol celloedd T gama / delta a'u hecsbloetio mewn therapi canser"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Malcolm Mason, Yr Athro Peter Barrett-Lee)
£ 170,067
2009-2010
Ymgyrch Canser y Fron, Grant Peilot Bach
"Rôl TRAIL mewn cytotoxicity cyfryngol celloedd T gama / delta dynol tuag at gelloedd canser y fron"
Prif Ymgeisydd (cyd-ymgeisydd: Dr. Richard Clarkson)
£ 19,944
2008-2010
Llywodraeth Cynulliad Cymru, Gwobr Partneriaeth Ymchwil Iechyd MRC
"Rôl celloedd T mewn llid a haint sy'n gysylltiedig â dialysis peritoneal"
Prif Ymgeisydd (cyd-ymgeisydd: Yr Athro Nicholas Topley)
£ 209,660
2007-2010
Ysgoloriaeth MRC (i Raj Bansal)
"Cymorth celloedd B a ddarperir gan gelloedd T gama / delta dynol"
Prif Ymgeisydd (cyd-ymgeisydd: Yr Athro Bernhard Moser)
£ 55,050
2007-2011
Cynghorau Ymchwil y DU
Cymrodoriaeth RCUK mewn Ymchwil Drosiadol mewn Meddygaeth Arbrofol
£ 125,000
2007
Ymddiriedolaeth Wellcome, Gwobr 'Gwerth mewn Pobl'
"Celloedd wrth bontio ymatebion imiwnedd cynhenid ac addasol"
Prif Ymgeisydd (cyd-ymgeisydd: Yr Athro Paul Morgan)
£ 34,786
Addysgu
Er mwyn goresgyn cymhlethdod anhygoel y system imiwnedd a'i wasgu i rannau treuliadwy, mae addysgu imiwnoleg yn aml mewn perygl o or-symleiddio senarios a/neu ddilyn ffasiynau dros dro. Y prif heriau yw cadw i fyny â'r llenyddiaeth ddiweddaraf ac ymgorffori datblygiadau diweddar yn y gwersi; i gludo brwdfrydedd rhywun ei hun dros wyddoniaeth i'r myfyrwyr; i ddangos y gall hyd yn oed y mecanweithiau mwyaf cymhleth fod o berthnasedd clinigol enfawr mewn iechyd a chlefydau; ac i wynebu myfyrwyr â dulliau safonol mewn labordai diagnostig ac ymchwil, ond hefyd i'w gwneud yn ymwybodol o bosibiliadau technoleg fodern. Fy nod yw addysgu myfyrwyr meddwl agored a beirniadol sy'n cael yr holl offer gwyddonol ond hefyd rhyngbersonol sydd eu hangen ar gyfer gallu cwestiynu safbwyntiau cyfoes a datrys problemau newydd.
Rwy'n ymrwymedig i gefnogi'r cwricwlwm meddygol trwy addysgu, dysgu a diweddaru proffesiynol. Rwyf wedi cyfrannu at addysgu grŵp bach effeithiol o fewn modiwlau SSC Blwyddyn 2 "Imiwnoleg Ryngweithiol" ac "Ymgysylltu â'r cyhoedd" yn ogystal ag adolygiadau llenyddiaeth SSC Blwyddyn 1, ac wedi addysgu mewn modiwlau ar imiwnopatholeg / imiwnotherapiwteg ac ar biofarcwyr / diagnosteg i fyfyrwyr Blwyddyn 3 a myfyrwyr rhyngweithiol, a rhoi tiwtorialau grŵp bach i fyfyrwyr Blwyddyn 1. Rwyf yn ymwneud â'r MSc "Imiwnoleg Clinial Gymhwysol ac Arbrofol", ac wedi bod yn gweithredu fel Tiwtor Personol/Mentor Academaidd ar gyfer israddedigion meddygol.
Rwyf wedi hyfforddi a mentora myfyrwyr israddedig ac ôl-raddedig yn y labordy, gan gynnwys myfyrwyr profiad gwaith ac interniaeth, a myfyrwyr MD a PhD o'r DU, Cyprus, Gwlad Groeg, yr Eidal, yr Iseldiroedd, Gwlad Pwyl, Slofenia, Taiwan a Tanzania. Rwyf wedi gwasanaethu ar y paneli arfarnu blynyddol ar gyfer >50 o fyfyrwyr PhD a MD ers 2014, ac rwyf wedi cael fy mhenodi'n arholwr mewnol ac yn gadeirydd traethodau PhD ym Mhrifysgol Caerdydd ac yn arholwr allanol traethodau PhD yn y DU, Awstria, Gwlad Belg, Ffrainc, Iwerddon, Sweden, yr Eidal, Sbaen, Portiwgal ac Awstralia.
Bywgraffiad
Proffil gyrfa
- Ers 2018
Athro Imiwnoleg Drosiadol, Is-adran Heintiau ac Imiwnedd, Ysgol Meddygaeth, Prifysgol Caerdydd
- 2015-2018
Darllenydd, Is-adran Heintiau ac Imiwnedd, Ysgol Meddygaeth, Prifysgol Caerdydd
- 2011-2015
Uwch Ddarlithydd, Sefydliad Heintiau ac Imiwnedd Caerdydd, Ysgol Meddygaeth, Prifysgol Caerdydd
- 2007-2011
Cymrawd RCUK mewn Ymchwil Drosiadol mewn Meddygaeth Arbrofol, Ysgol Meddygaeth, Prifysgol Caerdydd
- 2005-2006
Postdoc, Sefydliad Bioleg Celloedd, Prifysgol Bern (Y Swistir)
Lab: Yr Athro Bernhard Moser
- 2000-2005
Postdoc, Sefydliad Biocemeg, Ysgol Meddygaeth, Prifysgol Giessen (Yr Almaen)
Lab: Dr Hassan Jomaa
- 1998-2000
Postdoc, Adran Bioleg, Prifysgol Efrog (DU)
Lab: Yr Athro Alan Wilson
- 1995-1998
Myfyriwr PhD, Sefydliad Biocemeg, Ysgol Meddygaeth, Prifysgol Giessen (Yr Almaen)
Lab: Yr Athro Ewald Beck
Anrhydeddau a dyfarniadau
- 2025: Gwobr Ymgysylltu â'r Cyhoedd, Athrofa'r Gwyddor Biofeddygol (ar y cyd â Dr Jon Tyrrell; 'Superbugs')
- 2022: Gwobr Allgymorth Microbioleg, Cymdeithas Microbioleg (i Dr Jon Tyrrell ar ran tîm 'Superbugs')
- 2021: Gwobr Poster "Addysg ac Ymgysylltu â'r Cyhoedd", Cymdeithas Imiwnoleg Prydain (ar ran tîm 'Superbugs')
- 2018: Dyrchafiad i Gadeirydd Personol, Prifysgol Caerdydd
- 2015: Dyrchafiad i Ddarllenydd, Prifysgol Caerdydd
- 2011: Dyrchafiad i Uwch Ddarlithydd, Prifysgol Caerdydd
- 2009: Gwobr Cyfathrebu Am Ddim Gorau, Cyfarfod Dialysis Peritoneal Ewropeaidd, Strasbwrg, Ffrainc
- 2007: Cymrodoriaeth RCUK mewn Ymchwil Drosiadol mewn Meddygaeth Arbrofol
- 2007: Gwobr 'VIP' Ymddiriedolaeth Wellcome
Aelodaethau proffesiynol
- Cymdeithas Imiwnoleg Prydain (BSI):
Ysgrifennydd Ymgysylltu â'r Cyhoedd, 2023-2026;
Bwrdd yr Ymddiriedolwyr, 2017-2023;
Cynrychiolydd Rhanbarthol Cymru, Fforwm BSI, 2009-2016;
Cadeirydd Grŵp Imiwnoleg De Cymru, 2007-2015;
Aelod llawn ers 1998
Pwyllgorau ac adolygu
Rolau arwain
- ers 2026: Arweinydd Dinesig Byd-eang, Ysgol Feddygaeth, Prifysgol Caerdydd
- ers 2025: Cyd-arweinydd Academaidd ar gyfer y rhaglen 'Gwyddoniaeth mewn Iechyd', Ysgol Feddygaeth, Prifysgol Caerdydd
- 2020-2026: Arweinydd Academaidd ar y Cyd ar gyfer Cyfranogiad ac Ymgysylltu â'r Cyhoedd, Ysgol Feddygaeth, Prifysgol Caerdydd
- ers 2015: Arweinydd Ymgysylltu, Sefydliad Ymchwil Imiwnedd Systemau, Prifysgol Caerdydd
- ers 2014: Cadeirydd Paneli Arfarnu PhD, Heintiau ac Imiwnedd, Prifysgol Caerdydd
- ers 2011: Sylfaenydd a Gweinyddwr, γδ T Cell Forum
- ers 2009: Golygydd Gwe, Heintiau ac Imiwnedd, Prifysgol Caerdydd
Byrddau cynghori gwyddonol
- ers 2026: Gove Nanomaterials, Abertawe/Caerdydd, DU
- ers 2026: IntelliStem Technologies, Toronto, Canada
Arholwr PhD
- Prifysgol Caerdydd
- Coleg y Brenin Llundain
- Coleg y Drindod, Dulyn, Iwerddon
- Prifysgol Genedlaethol Iwerddon, Maynooth
- Prifysgol Antwerp, Gwlad Belg
- Prifysgol Bordeaux, Ffrainc
- Université Libre de Bruxelles, Gwlad Belg
- Prifysgol Lisbon, Portiwgal
- Prifysgol Melbourne, Awstralia
- Universidad Autónoma de Madrid, Sbaen
- Prifysgol Monash, Awstralia
- Prifysgol Palermo, yr Eidal
- Prifysgol Stockholm, Sweden
- Prifysgol Feddygol Fienna, Awstria
Arholwr allanol ar gyfer cyrsiau prifysgol
- MSc Imiwnoleg, Prifysgol Manceinion, DU
Adolygydd ar gyfer cyrff cyllido
- AERES - Asiantaeth Gwerthuso ar gyfer Ymchwil ac Addysg Uwch, Ffrainc
- ATIP-Avenir (CNRS / Inserm), Ffrainc
- Barts and The London Charity, DU
- BBSRC - Cyngor Ymchwil Biotechnoleg a Gwyddorau Biolegol, DU
- Cronfa Boehringer Ingelheim, Yr Almaen
- Canser y Fron Nawr, DU
- Ymchwil Canser y DU
- Cymdeithas Ymchwil Crohn mewn Plentyndod (CICRA), y DU
- Crohn's a Colitis UK
- Deutsche Forschungsgemeinschaft (DFG), Yr Almaen
- Cymdeithas Canser yr Iseldiroedd (KWF), Yr Iseldiroedd
- Cyngor Ymchwil yr Iseldiroedd (NWO), Yr Iseldiroedd
- Cyngor Ymchwil Ewropeaidd (ERC)
- Sefydliad Gwyddoniaeth Ewrop (ESF)
- Fondation pour la Recherche Médicale, Ffrainc
- Sefydliad Almaeneg-Israel ar gyfer Ymchwil a Datblygu Gwyddonol
- Institut National du Cancer (INCa), Ffrainc
- Cronfa Lewcemia Kay Kendall, DU
- Ymchwil Arennau y DU
- Cronfa Her Ymchwil a Datblygu Partneriaid Iechyd y Brenin, y DU
- MRC - Cyngor Ymchwil Feddygol, DU
- Weinyddiaeth Gwyddoniaeth, Technoleg a Gofod, Israel
- Cymdeithas Sglerosis Ymledol, DU
- Y Ganolfan Genedlaethol ar gyfer Amnewid, Mireinio a Lleihau Anifeiliaid mewn Ymchwil (NC3Rs), y DU
- Y Sefydliad Cenedlaethol ar gyfer Ymchwil Iechyd (NIHR), DU
- Cyngor Ymchwil Norwy
- Cyngor Grantiau Ymchwil, Hong Kong
- Coleg Prifysgol Cork, Iwerddon
- Fonds de la Recherche Scientifique, Gwlad Belg
- Prifysgol Liège, Gwlad Belg
- Ymddiriedolaeth Wellcome, DU
- Sefydliad Wilhelm Sander, Yr Almaen
Adolygydd ar gyfer cyfnodolion gwyddonol
- American Journal of Physiology - Ffisioleg Arennol
- Gwaed
- Asgwrn
- Imiwnoleg BMC
- Ymchwil Canser y Fron
- Imiwnoleg Canser Imiwnotherapi
- Ymchwil Canser
- Carcinogenesis
- Biocemeg a Swyddogaeth Celloedd
- Adroddiadau Celloedd
- Imiwnoleg Gellog
- Cronobioleg Ryngwladol
- Ymchwil Canser Clinigol
- Imiwnoleg Glinigol a Datblygiadol
- Imiwnoleg Glinigol ac Arbrofol
- Meddygaeth Glinigol ac Arbrofol
- Bioleg Cyfathrebu
- Targedau Cyffuriau Canser Cyfredol
- Adolygiadau Imiwnoleg Cyfredol
- Cytocin
- Imiwnoleg Darganfod
- Mewngofnodi
- Adroddiadau EMBO
- Cyfnodolyn Ewropeaidd Microbioleg Glinigol a Chlefydau Heintus
- Cyfnodolyn Imiwnoleg Ewropeaidd
- Parasitoleg Arbrofol
- Cylchgrawn FASEB
- Cylchgrawn FEBS
- Ffiniau mewn Imiwnoleg
- Ffiniau mewn Llawfeddygaeth
- Haematologica
- Cyfnodolyn Addysg Iechyd
- Disgwyliadau Iechyd
- Imiwnoleg Ddynol
- Imiwnoleg
- Imiwnoleg a Bioleg Celloedd
- Llythyrau Imiwnoleg
- Haint ac Imiwnedd
- Imiwnoleg Ryngwladol
- Cyfnodolyn Rhyngwladol Organau Artiffisial
- Cyfnodolyn Rhyngwladol Imiwnogeneteg
- Wwroleg a Neffroleg Ryngwladol
- Mewnwelediad JCI
- Journal of the American Chemical Society
- Cyfnodolyn Cymdeithas Neffroleg America
- Cyfnodolyn Cemeg Biolegol
- Cyfnodolyn Rheoleiddwyr Biolegol ac Asiantau Homeostatig
- Cyfnodolyn Ymchwilio Clinigol
- Cyfnodolyn Meddygaeth Arbrofol
- Cyfnodolyn Imiwnoleg
- Cyfnodolyn Clefydau Heintus
- Cyfnodolyn Bioleg Leukocyte
- Cyfnodolyn Cemeg Meddyginiaethol
- Cyfnodolyn Addysg Microbioleg a Bioleg
- Cyfnodolyn Meddygaeth Moleciwlaidd
- Cyfnodolyn Meddygaeth Drosiadol
- Arennau Rhyngwladol
- Cylchgrawn Malaria
- Microbau a Haint
- Imiwnoleg Moleciwlaidd
- Imiwnoleg y mwcos
- Natur
- Cyfathrebu Natur
- Adolygiadau Natur Imiwnoleg
- Neffroleg, Dialysis, Trawsblannu
- OncoImiwnoleg
- Adolygiadau Oncoleg
- Imiwnoleg Parasitiaid
- Dialysis Peritoneal Rhyngwladol
- PLoS UN
- Pathogenau PLoS
- Datblygiadau Gwyddoniaeth
- Gwyddoniaeth Meddygaeth Drosiadol
- Adroddiadau Gwyddonol
- Tueddiadau mewn imiwnoleg
- Tueddiadau mewn Meddygaeth Moleciwlaidd
- Tueddiadau mewn parasitoleg
Meysydd goruchwyliaeth
Ardaloedd goruchwylio
- Haint ac imiwnedd
- Celloedd T anghonfensiynol
- Cynnwys ac ymgysylltu â'r cyhoedd
(interniaethau, prosiectau MSc / MPhil / MD / PhD)
Goruchwyliaeth gyfredol
Prosiectau'r gorffennol
Myfyrwyr PhD
Linda Moet (PhD 2023, Prifysgol Caerdydd):
"Egluro llwybr metabolit imiwnedd mewn sepsis"
(Cyd-oruchwylydd; prif oruchwyliwr Peter Ghazal, gyda Valerie O'Donnell)
Ross Burton (PhD 2023, Prifysgol Caerdydd):
"Nodi biofarcwyr imiwnolegol sepsis gan ddefnyddio cytometrig, biowybodeg a dysgu peiriannau"
(Prif oruchwylydd; gydag Andreas Artemiou, Peter Ghazal, Matt Morgan)
Teja Rus (PhD 2021, Prifysgol Caerdydd):
"Cynhyrchu offer arbrofol ar gyfer astudio prosesu antigen tiwmor gan T-APCs γδ dynol: Prosesu antigenau tiwmor ac ymsefydlu imiwnedd gwrth-tiwmor"
(Cyd-oruchwyliwr; prif oruchwyliwr Bernhard Moser)
Ariadni Kouzeli (PhD 2020, Prifysgol Caerdydd):
"Swyddogaeth CXCL14 a chelloedd targed mewn meinweoedd iach"
(Cyd-oruchwyliwr; prif oruchwyliwr Bernhard Moser)
Amy Brook (PhD 2019, Prifysgol Caerdydd):
"MicroRNAs lleol mewn cleifion dialysis peritoneal â peritonitis acíwt"
(Prif oruchwylydd; gyda Donald Fraser, Tim Bowen)
Chris Tyler (PhD 2016, Prifysgol Caerdydd):
"Rheoli ymatebion celloedd T CD4 + gan γδ T-APCs"
(Prif oruchwylydd; gyda Bernhard Moser)
Anna Rita Liuzzi (PhD 2015, Prifysgol Caerdydd):
"Ymatebion llidiol anghonfensiynol a yrrir gan gelloedd T yn ystod peritonitis acíwt: goblygiadau ar gyfer diagnosis a therapi cleifion dialysis peritoneal"
(Prif oruchwylydd; gyda Tim Bowen)
Hung-Chang Chen (PhD 2015, Prifysgol Caerdydd):
"Imiwnotherapi sy'n seiliedig ar gelloedd T γδ dynol ar gyfer canser y fron"
(Prif oruchwylydd; gyda Richard Clarkson)
Matt Morgan (PhD 2014, Prifysgol Caerdydd):
"Immune fingerprinting in acute severe sepsis"
(Cyd-oruchwylydd; prif oruchwyliwr Judith Hall)
Luke Piggott (PhD 2012, Prifysgol Caerdydd):
"Ymchwilio i botensial therapiwtig protein ataliol tebyg i FLICE-like cellog a TRAIL mewn modelau cyn-glinigol o ganser y fron"
(Cyd-oruchwyliwr; prif oruchwyliwr Richard Clarkson)
Chan-Yu Lin (PhD 2012, Prifysgol Caerdydd):
"Rôl celloedd T γδ mewn haint bacteriol sy'n gysylltiedig â dialysis peritoneal"
(Prif oruchwylydd; gyda Nick Topley)
Martin Davey (PhD 2012, Prifysgol Caerdydd):
"Croessiarad cellog celloedd T Vγ9 / Vδ2 dynol, niwtroffilau a monocytau mewn ymateb i heintiau bacteriol"
(Prif oruchwylydd; gyda Bernhard Moser)
Raj Bansal (PhD 2012, Prifysgol Caerdydd):
"Cymorth celloedd B a ddarperir gan gelloedd T γδ dynol"
(Prif oruchwylydd; gyda Bernhard Moser)
Myfyrwyr MD
Nicola Reeves (Rheolwr Gyfarwyddwr 2021, Prifysgol Caerdydd):
"Effaith safoni newidynnau intra-operative ar yr achosion o heintiau safle llawfeddygol mewn llawfeddygaeth a'r rhefr yng Nghymru"
(Cyd-oruchwylydd; prif oruchwyliwr Jared Torkington, gydag Ian Weeks)
Myfyrwyr MPhil
Daniel Griffiths (MPhil 2026, Prifysgol Caerdydd):
"Celloedd T anghonfensiynol: Ymateb i haint bacteriol acíwt a llofnodion imiwnedd ar gyfer gollyngiadau anastomotig"
(Prif oruchwylydd; gydag Andreas Artemiou)
Emily Jacob (MPhil 2022, Prifysgol Caerdydd):
"Immune fingerprinting of bacterial infections in decompensated cirrhosis"
(Cyd-oruchwylydd; prif oruchwyliwr Thomas Pembroke)
Myfyrwyr MSc
Emily Pockett (MSc 2025, Prifysgol Caerdydd):
"Nodweddu celloedd T CXCR5 + Vγ9 / Vδ2 + a'u rôl yn yr ymateb humoral"
(Prif oruchwylydd; gyda James McLaren, Kirsty Emery)
Abdulgafar Abdulsalam (MSc 2025, Prifysgol Abertawe):
"Superbugs: Dilyniant siop dros dro"
(Cyd-oruchwylydd; prif oruchwyliwr Jon Tyrrell)
Al-Motaz Rizek (MSc 2024, Prifysgol Caerdydd):
"Modiwleiddio imiwnedd humoral cyfryngol celloedd T yn ystod haint bacteriol difrifol"
(Cyd-oruchwylydd; prif oruchwyliwr James McLaren, gyda Kate Davies)
Ogbukagu Chioma (MSc 2024, Prifysgol Abertawe):
"Pennu agweddau academaidd at ymgysylltu â'r cyhoedd mewn ymwrthedd gwrthficrobaidd"
(Cyd-oruchwylydd; prif oruchwyliwr Jon Tyrrell)
Sona Galla (MSc 2024, Prifysgol Abertawe):
"Sgrinio amgylcheddol ar gyfer ymwrthedd gwrthficrobaidd (AMR) wedi'i bweru gan ymgysylltu â'r cyhoedd effeithiol"
(Cyd-oruchwylydd; prif oruchwyliwr Jon Tyrrell)
Oluwatimilehin Okundalaye (MSc 2024, Prifysgol Abertawe):
"Gwella dealltwriaeth ac atal ymfedd gwrthficrobaidd (AMR) mewn ysgolion trwy ddysgu gamified"
(Cyd-oruchwylydd; prif oruchwyliwr Jon Tyrrell)
Amalraj Eyyath Veettil (MSc 2024, Prifysgol Abertawe):
"Datblygu a gwerthuso deunydd addysg digidol i wella ymwybyddiaeth y cyhoedd o reoli heintiau"
(Cyd-oruchwylydd; prif oruchwyliwr Jon Tyrrell)
Josephine Banda (MSc 2023, Prifysgol Caerdydd):
"Archwilio'r dirwedd imiwnomodulatory mewn haint P. falciparum asymptomatig"
(Cyd-oruchwylydd; prif oruchwyliwr Ian Humphreys)
Lucy Sheikh (MSc 2023, Prifysgol Caerdydd):
"Celloedd T gwrthficrobaidd camweithredol imiwnofenoteipio yn ystod sepsis"
(Cyd-oruchwylydd; prif oruchwyliwr James McLaren)
Haritha Ayanikkad (MSc 2023, Prifysgol Abertawe):
"Astudiaeth ar ymgysylltu â'r cyhoedd i wella hylendid bwyd a llythrennedd microbaidd mewn plant ysgol"
(Cyd-oruchwylydd; prif oruchwyliwr Jon Tyrrell)
Vasudev Gopakumar (MSc 2023, Prifysgol Abertawe):
"Ymgysylltu â'r cyhoedd mewn hylendid a microbioleg ymhlith plant ifanc trwy ymyriadau llwyddiannus"
(Cyd-oruchwylydd; prif oruchwyliwr Jon Tyrrell)
Chiamaka Nnamdi (MSc 2023, Prifysgol Abertawe):
"Creu ymwybyddiaeth o ymwrthedd gwrthficrobaidd i blant rhwng 7 a 14 oed gan ddefnyddio Staphylococcus aureus fel astudiaeth achos"
(Cyd-oruchwylydd; prif oruchwyliwr Jon Tyrrell)
Rachel Oyebode (MSc 2023, Prifysgol Abertawe):
"Creu ymwybyddiaeth o ymwrthedd gwrthficrobaidd mewn plant gan ddefnyddio Staphylococcus aureus fel astudiaeth achos"
(Cyd-oruchwylydd; prif oruchwyliwr Jon Tyrrell)
Katherine Stanswood (MSc 2022, Prifysgol Caerdydd):
"Mecanweithiau imiwnoffenoteipio camweithrediad celloedd T yn ystod dechrau sepsis"
(Cyd-oruchwylydd; prif oruchwyliwr James McLaren)
Ymgysylltu
I am passionate about engaging and involving the public in my research and disseminate relevant findings to specialist and lay audiences.
As Engagement Lead of the Systems Immunity Research Institute, I conceive, oversee and coordinate a wide range of engagement and involvement activities, and aim to reach out to all stake-holders in our research - patients, health care providers, schools, policy makers, media, funders, industry and the general public.
I established and chair a Lay Faculty for the Systems Immunity Research Institute consisting of members of the public who provide valuable feedback on research proposals, study protocols, consent forms, news items and press releases, and help foster a close dialogue between local scientists and the wider public. This Lay Faculty has developed into a flagship involvement activity at Cardiff University and has received very positive feedback from Health and Care Research Wales and the Wellcome Trust.
In addition to facilitating and promoting engagement activities by colleagues across the Systems Immunity Research Institute and the College of Biomedical and Life Sciences, over the past 3 years I directly developed and contributed to activities such as 1) showcasing Cardiff research twice at Techniquest, the local Science museum; 2) promoting the importance of international research and collaboration for Cardiff University, Wales and the UK at receptions in the National Assembly for Wales and the House of Commons; 3) hosting the MP for Cardiff Central, Jo Stevens, at the Annual Infection & Immunity Meeting 2017; 4) creating educational computer games for primary schools; 5) developing a Welsh-medium philosophy/immunology workshop for primary school children; 6) establishing contacts with Radio Glamorgan, the local hospital radio station; 7) designing a Cardiff-wide bus stop poster campaign; 8) running a university-wide picture/artwork competition; 9) celebrating diversity and equality across Infection & Immunity, the School of Medicine and the University as a whole, and promoting the importance of international collaboration and training for local research and innovation; and 10) collaborating with BBC Wales on a programme about sepsis involving BBC weatherman Derek Brockway, and on sourcing laboratory equipment and props for the Dr Who Christmas Special 2014.
As Web Editor of the Systems Immunity URI (and its predecessors, the i3-IRG and the Institute of Infection & Immunity, since 2009), I have substantially improved the visibility of local research, teaching, innovation and engagement, accompanied by successful social media accounts (>1,600 Twitter followers). I also created an interactive ‘γδ T cell Forum’, which has >1,000 followers from >50 countries and has developed into a key networking resource in the field.
Through my participation in the core activities of the British Society for Immunology (BSI), the largest immunological society in Europe, I directly promote immunology-related research, public engagement and education in Wales, the UK and beyond. I was elected as BSI Trustee in 2017, after serving two terms as Regional Representative for Wales on the BSI Forum (2010-2016), the Society’s ‘think tank’. As one of only 12 Trustees, I am directly responsible for the effective operation of the Society, with regard to finance, governance, strategy and supervision of its CEO. As Chairman of the BSI South Wales regional group (2007-2015), I established Cardiff as one of the most active and visible regional groups in the UK, increased its annual budget eight-fold, and created the prestigious annual Jonathan Boulter Memorial Lecture given by the leading immunologists in the world.
News articles
Contact Details
+44 29206 87011
Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Ystafell 3F08, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Themâu ymchwil
Arbenigeddau
- Imiwnoleg
- Afiechydon heintus
- Cynnwys ac ymgysylltu â'r cyhoedd
- Imiwnedd celloedd T
- Biofarcwyr
