![Matthias Eberl](https://profiles-cardiff.imgix.net/attachments/4232?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Matthias Eberl
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Matthias Eberl
Athro Imiwnoleg Drosiadol, Is-adran Heintiau ac Imiwnedd. Arweinydd Academaidd ar y Cyd ar gyfer Cynnwys ac Ymgysylltu â'r Cyhoedd, Ysgol Meddygaeth.
Trosolwyg
Rwyf bob amser wedi bod â diddordeb yn sail foleciwlaidd a chellog perthnasoedd cyd-pathogen lletyol a modiwleiddio sylfaenol ymatebion imiwnedd cymhleth.
Yn ystod fy PhD yn Giessen sefydlais ddull sgrinio i nodi antigenau celloedd CD4+ T o lyfrgelloedd cDNA y parasit Schistosoma mansoni. Yna estynnais yr astudiaethau hyn yn ystod postdoc dwy flynedd yn Efrog (DU), ac ymchwiliais i'r ymateb imiwnedd cellog a doniol i sgitsosomau ar yr haint a'r brechiad.
Mae fy ymchwil ers 2000 yn Giessen, Bern a Chaerdydd wedi canolbwyntio ar ddiffinio rôl celloedd γδ T dynol wrth bontio ymatebion imiwnedd cynhenid ac addasol.
celloedd T yw'r prototeip o lymffocytau 'anghonfensiynol' gan nad ydynt yn cael eu cyfyngu gan MHC clasurol ac yn cyfuno nodweddion celloedd T 'confensiynol', celloedd NK a chelloedd myeloid. Fel arfer dim ond poblogaeth fach mewn gwaed dynol yn unig y maent yn ei gyfansoddi, maent yn meddiannu cilfach unigryw mewn cydnabyddiaeth ficrobaidd ac yn cyfrannu at wyliadwriaeth straen ac amddiffyn rhwystrau.
Yn fwy diweddar, dechreuon ni nodweddu ymatebion imiwnedd cynnar mewn cleifion sydd wedi'u heintio'n aciwt, a diffinio llofnodion pathogen-benodol biomarcwyr cellog a hydawdd ('olion bysedd imiwnedd'), gan ddefnyddio cytometreg llif, technegau ELISA amlblecs a dulliau mathemategol.
Gosodir ein gwaith ar ryngwyneb ymchwil sylfaenol, drosiadol, cyfrifiannol a chlinigol, ac mae'n elwa'n fawr o gydweithrediadau rhyngddisgyblaethol ag imiwnolegwyr, microbiolegwyr, biocemegwyr, epidemiolegwyr, gwyddonwyr data, clinigwyr a phartneriaid masnachol.
Yn ogystal â goblygiadau ar gyfer diagnosis a thrin heintiau microbaidd, mae gan ein gwaith ganlyniadau ar gyfer dylunio brechlyn ac imiwnotherapi.
Cyhoeddiad
2025
- Eberl, M. 2025. Highlights of 2024: γδ T cells and bad blood. Immunology & Cell Biology (10.1111/imcb.70012)
2024
- Giannoni, E. et al. 2024. Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner. European Journal of Immunology 54(10), article number: 2451190. (10.1002/eji.202451190)
- Burton, R. J. et al. 2024. Conventional and unconventional T cell responses contribute to the prediction of clinical outcome and causative bacterial pathogen in sepsis patients. Clinical & Experimental Immunology 216(3), pp. 293-306. (10.1093/cei/uxae019)
- Damani-Yokota, P. and Eberl, M. 2024. The γδ T Cell Club: bringing a global scientific community together in the age of Zoom. Immunology & Cell Biology 102(5), pp. 302-307. (10.1111/imcb.12742)
- Tyrrell, J. M., Ayanikkad, H. U., Nalleppilil-Gopakumar, V., Oyebode, R., Nmamdi Blessing, C., Hatch, S. and Eberl, M. 2024. Combining postgraduate research training, public engagement and primary school science education - A Superbugs Master (MSc) class. Frontiers in Microbiology (10.3389/fmicb.2024.1380045)
- Nollett, C., Eberl, M., Fitzgibbon, J., Joseph-Williams, N. and Hatch, S. 2024. Public involvement and engagement in scientific research and higher education: The only way is ethics?. Research Involvement and Engagement 10(1), article number: 50. (10.1186/s40900-024-00587-x)
- Leon-Lara, X. et al. 2024. γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis. Journal of Experimental Medicine 221(7), article number: e20231987. (10.1084/jem.20231987)
- Eberl, M. and Cruickshank, S. M. 2024. A culture shift to support public involvement and engagement in research. Journal of Experimental Medicine 221(6), article number: e20240268. (10.1084/jem.20240268)
- Tyler, C. J. et al. 2024. IL-21 conditions antigen-presenting human γδ T-cells to promote IL-10 expression in naïve and memory CD4+ T-cells. Discovery Immunology (10.1093/discim/kyae008)
- Tyrrell, J. et al. 2024. Superbugs online: co-production of an educational website to increase public understanding of the microbial world in, on and around us. Frontiers in Microbiology 15, article number: 1340350. (10.3389/fmicb.2024.1340350)
2023
- Silva-Santos, B., Ribot, J. C., Adams, E. J., Willcox, B. E. and Eberl, M. 2023. γδ T cell explorations seek terra firma. Nature Immunology 24, pp. 1606-1609. (10.1038/s41590-023-01606-x)
- Eberl, M., Joseph-Williams, N., Nollett, C., Fitzgibbon, J. and Hatch, S. 2023. Overcoming the disconnect between scientific research and the public. Immunology and Cell Biology 101(7), pp. 590-597. (10.1111/imcb.12657)
- Cuff, S. et al. 2023. Inflammatory biomarker signatures in post-surgical drain fluid may detect anastomotic leaks within 48 hours of colorectal resection. Techniques in Coloproctology (10.1007/s10151-023-02841-y)
- Burton, R. J., Cuff, S. M., Morgan, M. P., Artemiou, A. and Eberl, M. 2023. GeoWaVe: Geometric median clustering with weighted voting for ensemble clustering of cytometry data. Bioinformatics 39(1), article number: btac751. (10.1093/bioinformatics/btac751)
2022
- Cuff, S. M., Merola, J. P., Eberl, M. and Gray, W. P. 2022. Presence of ventriculoperitoneal and lumbar shunts stimulate long lasting non-inflammatory changes in the cerebrospinal fluid distinct from the response to bacterial infection. [Online]. medRxiv. (10.1101/2022.10.12.22280998) Available at: https://doi.org/10.1101/2022.10.12.22280998
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Ponsford, M. J. et al. 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75(4), pp. 255-262. (10.1136/jclinpath-2020-207157)
- Tyrrell, J. M. et al. 2022. 'Superbugs': raising public awareness of antimicrobial resistance through a pop-up science shop. Research for All 6(1), pp. 1-21. (10.14324/RFA.06.1.06)
2021
- Kaminski, H., Couzi, L. and Eberl, M. 2021. Unconventional T cells and kidney disease. Nature Reviews Nephrology 17, pp. 795-813. (10.1038/s41581-021-00466-8)
- Eberl, M., Oldfield, E. and Herrmann, T. 2021. Editor's Note: Relates to: 'Immuno-antibiotics: targeting microbial metabolic pathways sensed by unconventional T cells'. Immunotherapy Advances 1(1), article number: ltab023. (10.1093/immadv/ltab023)
- Burton, R. J., Ahmed, R., Cuff, S. M., Baker, S., Artemiou, A. and Eberl, M. 2021. CytoPy: An autonomous cytometry analysis framework. PLoS Computational Biology 17(6), article number: e1009071. (10.1371/journal.pcbi.1009071)
- Eberl, M., Oldfield, E. and Herrmann, T. 2021. Immuno-antibiotics: Targeting microbial metabolic pathways sensed by unconventional T cells. Immunotherapy Advances 1(1), article number: ltab005. (10.1093/immadv/ltab005)
2020
- Cuff, S. M., Merola, J. P., Twohig, J. P., Eberl, M. and Gray, W. P. 2020. Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation. Brain Communications 2(2), article number: fcaa218. (10.1093/braincomms/fcaa218)
- Kouzeli, A. et al. 2020. CXCL14 preferentially synergizes with homeostatic chemokine receptor systems. Frontiers in Immunology 11, article number: 561404. (10.3389/fimmu.2020.561404)
- Goodlad, C. et al. 2020. Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis. Kidney International 97(6), pp. 1253-1259. (10.1016/j.kint.2020.01.044)
- Catar, R. A. et al. 2020. Control of neutrophil influx during peritonitis by transcriptional cross-regulation of chemokine CXCL1 by IL‐17 and IFN‐γ. Journal of Pathology 251(2), pp. 175-186. (10.1002/path.5438)
- Eberl, M. 2020. Antigen recognition by human γδ T cells: one step closer to knowing. Immunology and Cell Biology 98(5), pp. 351-354. (10.1111/imcb.12334)
- Raffray, L., Burton, R. J., Baker, S. E., Morgan, M. P. and Eberl, M. 2020. Zoledronate rescues immunosuppressed monocytes in sepsis patients. Immunology 159(1), pp. 88-95. (10.1111/imm.13132)
2019
- Gadalla, A. A. M. et al. 2019. Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms. Scientific Reports 9(1), article number: 19694. (10.1038/s41598-019-55523-x)
- Nguyen, C. T., Maverakis, E., Eberl, M. and Adamopoulos, I. E. 2019. γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity. Seminars in Immunopathology 41(5), pp. 595-605. (10.1007/s00281-019-00752-5)
- Burton, R. J., Albur, M., Eberl, M. and Cuff, S. M. 2019. Using artificial intelligence to reduce diagnostic workload without compromising detection of urinary tract infections. BMC Medical Informatics and Decision Making 19(1), article number: 171. (10.1186/s12911-019-0878-9)
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9, article number: 10136. (10.1038/s41598-019-46585-y)
- Pottanat, N. D. et al. 2019. Analysis of the Ribonuclease a superfamily of antimicrobial peptides in patients undergoing chronic peritoneal dialysis. Scientific Reports 9, pp. -., article number: 7753. (10.1038/s41598-019-44219-x)
2018
- Vermijlen, D., Gatti, D., Kouzeli, A., Rus, T. and Eberl, M. 2018. γδ T cell responses: How many ligands will it take till we know?. Seminars in Cell and Developmental Biology 84, pp. 75-86. (10.1016/j.semcdb.2017.10.009)
- Chakera, A., Mulroney, K., Shak, H., McGuire, A., Eberl, M. and Topley, N. 2018. Peritonitis in Peritoneal Dialysis patients: the case for rapid diagnosis, targeted treatment and monitoring to improve outcomes. European Medical Journal Nephrology 6, pp. 56-64.
- McCarthy, N. E. and Eberl, M. 2018. Human γδ T-cell control of mucosal immunity and inflammation. Frontiers in Immunology 9, article number: 985. (10.3389/fimmu.2018.00985)
- Rhodes, D. A. et al. 2018. Regulation of human γδ T cells by BTN3A1 protein stability and ATP-binding cassette transporters. Frontiers in Immunology 9, article number: 662. (10.3389/fimmu.2018.00662)
2017
- Aufricht, C. et al. 2017. Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network. Kidney International 92(4), pp. 824-835. (10.1016/j.kint.2017.02.037)
- Chen, H. et al. 2017. Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells. Immunology and Cell Biology 95(7), pp. 620-629. (10.1038/icb.2017.21)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92(1), pp. 179-191. (10.1016/j.kint.2017.01.017)
- Howard, J. et al. 2017. The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection.. Journal of Infectious Diseases 215(10), pp. 1569-1579. (10.1093/infdis/jix149)
- Tyler, C. J., McCarthy, N. E., Lindsay, J. O., Stagg, A. J., Moser, B. and Eberl, M. 2017. Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin. The Journal of Immunology 198(9), article number: 1700003. (10.4049/jimmunol.1700003)
- Raby, A. et al. 2017. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology 28(2), pp. 461-478. (10.1681/ASN.2015080923)
2016
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990)
- Johansson, M. A. et al. 2016. Probiotic lactobacilli modulate staphylococcus aureus-induced activation of conventional and unconventional T cells and NK cells. Frontiers in Immunology 7, article number: 273. (10.3389/fimmu.2016.00273)
- Morgan, M., Szakmany, T., Power, S., Olaniyi, P., Kathy, R., Hall, J. E. and Eberl, M. 2016. Sepsis patients with first and second-hit infections show different outcomes depending on the causative organism. Frontiers in Microbiology 7, article number: 207. (10.3389/fmicb.2016.00207)
2015
- Liuzzi, A. R., McLaren, J. E., Price, D. and Eberl, M. 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36, pp. 31-37. (10.1016/j.coi.2015.06.002)
- Piggott, L., Omidvar, N., Martí Pérez, S., French, R., Eberl, M. and Clarkson, R. W. E. 2015. Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 17(1), pp. 96. (10.1186/s13058-015-0597-9)
- Bonneville, M. et al. 2015. Chicago 2014 – 30 years of γδ T cells. Cellular Immunology 296(1), pp. 3-9. (10.1016/j.cellimm.2014.11.001)
- Tyler, C. J., Doherty, D. G., Moser, B. and Eberl, M. 2015. Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system. Cellular Immunology 296(1), pp. 10-21. (10.1016/j.cellimm.2015.01.008)
- Rhodes, D. A. et al. 2015. Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. Journal of Immunology 194(5), pp. 2390-2398. (10.4049/jimmunol.1401064)
2014
- Eberl, M., Friberg, I. M., Liuzzi, A. R., Morgan, M. and Topley, N. 2014. Pathogen-specific immune fingerprints during acute infection: The diagnostic potential of human γδ T-cells. Frontiers in Immunology 5, article number: 572. (10.3389/fimmu.2014.00572)
- Khan, M. W. A., Eberl, M. and Moser, B. 2014. Potential use of γδ T cell-based vaccines in cancer immunotherapy. Frontiers in Immunology 5, article number: 512. (10.3389/fimmu.2014.00512)
- Davey, M. S. et al. 2014. Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells. Journal of Immunology 193(7), pp. 3704-3716. (10.4049/jimmunol.1401018)
- Khan, M. W. A. et al. 2014. Expanded human blood-derived gamma delta T cells display potent antigen-presentation functions. Frontiers in Immunology 5, article number: 344. (10.3389/fimmu.2014.00344)
2013
- Chen, H., Dieli, F. and Eberl, M. 2013. An unconventional TRAIL to cancer therapy. European Journal of Immunology 43(12), pp. 3159-3162. (10.1002/eji.201344105)
- Lin, C., Roberts, G. W., Kift-Morgan, A. P., Donovan, K., Topley, N. and Eberl, M. 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24(12), pp. 2002-2009. (10.1681/ASN.2013040332)
- Lin, C., Roberts, G. W., Kift-Morgan, A., Donovan, K. L., Topley, N. and Eberl, M. 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24(12), pp. 2002-2009. (10.1681/ASN.2013040332)
- Welton, J. L., Marti, S., Mahdi, M. H., Boobier, C., Barrett-Lee, P. and Eberl, M. 2013. γδ T cells predict outcome in zoledronate-treated breast cancer patients [Comment]. Oncologist 18(8), pp. E22-E23. (10.1634/theoncologist.2013-0097)
- Lin, C., Kift-Morgan, A. P., Moser, B., Topley, N. and Eberl, M. 2013. Suppression of pro-inflammatory T-cell responses by human mesothelial cells. Nephrology Dialysis Transplantation 28(7), pp. 1743-1750. (10.1093/ndt/gfs612)
- Welton, J. et al. 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28(3), pp. 464-471. (10.1002/jbmr.1797)
2012
- Silva-Santos, B., Schamel, W. W. A., Fisch, P. and Eberl, M. 2012. gamma delta T-cell conference 2012: Close encounters for the fifth time. European Journal of Immunology 42(12), pp. 3101-3105. (10.1002/eji.201270101)
- Riganti, C., Massaia, M., Davey, M. S. and Eberl, M. 2012. Human γδ T-cell responses in infection and immunotherapy: Common mechanisms, common mediators?. European Journal of Immunology 42(7), pp. 1668-1676. (10.1002/eji.201242492)
- Heuston, S., Begley, M., Davey, M., Eberl, M., Casey, P. G., Hill, C. and Gahan, C. G. M. 2012. HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe. Microbiology 158(7), pp. 1684-1693. (10.1099/mic.0.056069-0)
- Bansal, R. R., Mackay, C. R., Moser, B. and Eberl, M. 2012. IL-21 enhances the potential of human gamma delta T cells to provide B-cell help. European Journal of Immunology 42(1), pp. 110-119. (10.1002/eji.201142017)
2011
- Piggott, L., Omidvar, N., Marti-Perez, S., Eberl, M. and Clarkson, R. W. E. 2011. Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 13(5), article number: R88. (10.1186/bcr2945)
- Davey, M. S. et al. 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. Plos Pathogens 7(5), article number: e1002040. (10.1371/journal.ppat.1002040)
- Davey, M. S. et al. 2011. Failure to detect production of IL-10 by activated human neutrophils [Letter]. Nature Immunology 12(11), pp. 1017-1018. (10.1038/ni.2111)
- Moser, B. and Eberl, M. 2011. γδ T-APCs: a novel tool for immunotherapy? [Book Review]. Cellular and Molecular Life Sciences 68(14), pp. 2443-2452. (10.1007/s00018-011-0706-6)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
2010
- Meuter, S., Eberl, M. and Moser, B. 2010. Prolonged antigen survival and cytosolic export in cross-presenting human γδ T cells. Proceedings of the National Academy of Sciences of the United States of America 107(19), pp. 8730-8735. (10.1073/pnas.1002769107)
- Meraviglia, S. et al. 2010. In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Clinical and Experimental Immunology 161(2), pp. 290-297. (10.1111/j.1365-2249.2010.04167.x)
- Brown, A. C., Eberl, M., Crick, D. C., Jomaa, H. and Parish, T. 2010. The nonmevalonate pathway of isoprenoid biosynthesis in mycobacterium tuberculosis is essential and transcriptionally regulated by dxs. Journal of Bacteriology 192(9), pp. 2424-2433. (10.1128/JB.01402-09)
2009
- Eberl, M. and Moser, B. 2009. Monocytes and γδ T cells: close encounters in microbial infection. Trends in Immunology 30(12), pp. 562-568. (10.1016/j.it.2009.09.001)
- Eberl, M., Roberts, G. W., Meuter, S., Williams, J. D., Topley, N. and Moser, B. 2009. A rapid crosstalk of human gamma delta T cells and monocytes drives the acute inflammation in bacterial infections. Plos Pathogens 5(2), pp. 6-6., article number: e1000308. (10.1371/journal.ppat.1000308)
- Brandes, M. et al. 2009. Cross-presenting human gamma delta T cells induce robust CD8(+) alpha beta T cell responses. Proceedings of the National Academy of Sciences of the United States of America 106(7), pp. 2307-2312. (10.1073/pnas.0810059106)
2007
- Dieli, F. et al. 2007. Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Research 67(15), pp. 7450-7457. (10.1158/0008-5472.can-07-0199)
- Vermijlen, D. et al. 2007. Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. The Journal of Immunology 178(7), pp. 4304-4314. (10.4049/jimmunol.178.7.4304)
- Moser, B. and Eberl, M. 2007. gammadelta T cells: novel initiators of adaptive immunity [review]. Immunological Reviews 215(1), pp. 89-102. (10.1111/j.1600-065x.2006.00472.x)
- Zafranskaya, M., Oschamnn, P., Engel, R., Weishaupt, A., van Noort, J. M., Jomaa, H. and Eberl, M. 2007. Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis. Immunology 121(1), pp. 29-39. (10.1111/j.1365-2567.2006.02518.x)
2006
- Eberl, M., Wesch, D., Dieli, F. and Jomaa, H. 2006. Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells. Journal of Leukocyte Biology 79(4), pp. 663-6. (10.1189/jlb.1105640)
2005
- Eberl, M., Jomaa, H., Pircher, H. and Fisch, P. 2005. Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1). Journal of leukocyte biology 77, pp. 67-70. (10.1189/jlb.0204096)
2004
- Eberl, M., Beck, E., Christiansen, G. and Jamba, Z. 2004. Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so. Infection and Immunity 72(8), pp. 4881-3. (10.1128/IAI.72.8.4881-4883.2004)
- Eberl, M., Jomaa, H. and Hayday, A. C. 2004. Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells. Immunology 112(3), pp. 364-368. (10.1111/j.1365-2567.2004.01921.x)
- Begley, M., Gahan, C. G., Kollas, A. K., Hintz, M., Hill, C., Jomaa, H. and Eberl, M. 2004. The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. FEBS Letters 561(1-3), pp. 99-104. (10.1016/s0014-5793(04)00131-0)
2003
- Ostrovsky, D. N., Dyomina, G. R., Deryabina, Y. I., Goncharenko, A. ., Eberl, M., Shumaev, A. and Shashkov, S. 2003. Properties of 2-C-Methyl-D-Erythritol 2,4-Cyclopyrophosphate, an intermediate in Nonmevalonate Isoprenoid Biosynthesis. Applied Biochemistry and Microbiology c/c of Prikladnaia Biokhimiia i Mikrobiologiia 39(5), pp. 497-502. (10.1023/A:1025452804046)
- Eberl, M. and Jomaa, H. 2003. A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens [letter]. Trends in Immunology 24(8), pp. 407-409. (10.1016/s1471-4906(03)00170-4)
- Eberl, M., Hintz, M., Reichenberg, A., Kollas, A. K., Wiesner, J. and Jomaa, H. 2003. Microbial isoprenoid biosynthesis and human gammadelta T cell activation [review]. FEBS Letters 544(1-3), pp. 4-10. (10.1016/s0014-5793(03)00483-6)
- Reichenberg, A. et al. 2003. Replacing the pyrophosphate group of HMB-PP by diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism. Biorganic and Medicinal Chemistry Letters 13(7), pp. 1257-1260. (10.1016/s0960-894x(03)00138-0)
2002
- Kollas, A. K. et al. 2002. Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. FEBS Letters 532(3), pp. 432-436. (10.1016/s0014-5793(02)03725-0)
- Eberl, M., al-Sherbiny, M., Hagan, P., Ljubojevic, S., Thomas, A. W. and Wilson, R. A. 2002. A novel and sensitive method to monitor helminth infections by faecal sampling. Acta Tropica 83(2), pp. 183-187. (10.1016/s0001-706x(02)00089-x)
- Eberl, M., Engel, R., Beck, E. and Jomaa, H. 2002. Differentiation of human gamma-delta T cells towards distinct memory phenotypee. Cellular Immunology 218(1-2), pp. 1-6. (10.1016/s0008-8749(02)00519-1)
- Eberl, M. 2002. Don't count your interleukins before they've hatched [letter]. Trends in Immunology 23(7), pp. 341-342. (10.1016/s1471-4906(02)02239-1)
- Eberl, M. et al. 2002. Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology 106(2), pp. 200-211. (10.1046/j.1365-2567.2002.01414.x)
2001
- Hintz, M. et al. 2001. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Letters 509(2), pp. 317-322. (10.1016/s0014-5793(01)03191-x)
- Eberl, M. et al. 2001. Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees. Infection and Immunity 69(9), pp. 5352-5362. (10.1128/iai.69.9.5352-5362.2001)
- Altincicek, B. et al. 2001. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS Letters 499(1-2), pp. 37-40. (10.1016/s0014-5793(01)02516-9)
- Eberl, M. et al. 2001. Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?. Journal of Infectious Diseases 183(8), pp. 1238-1247. (10.1086/319691)
- Atincicek, B. et al. 2001. Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. The Journal of Immunology 166(6), pp. 3655-3658. (10.4049/jimmunol.166.6.3655)
- Kasper, G. et al. 2001. A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins. The Journal of Immunology 23(3), pp. 141-152. (10.1046/j.1365-3024.2001.00366.x)
2000
- Eberl, M., Beck, E., Coulson, P., Okamura, H., Wilson, R. A. and Mountford, A. P. 2000. IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigen. Vaccine 18(19), pp. 2002-2008. (10.1016/s0264-410x(99)00532-0)
1999
- Jomaa, H. et al. 1999. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285(5433), pp. 1573-1576. (10.1126/science.285.5433.1573)
- Eberl, M., Mountford, A. P., Jankovic, D. and Beck, E. 1999. Isolation of T-cell antigens by using a recombinant protein library and its application to the identification of novel vaccine candidates against schistosomiasis. Infection and Immunity 67(7), pp. 3383-3389.
Articles
- Eberl, M. 2025. Highlights of 2024: γδ T cells and bad blood. Immunology & Cell Biology (10.1111/imcb.70012)
- Giannoni, E. et al. 2024. Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner. European Journal of Immunology 54(10), article number: 2451190. (10.1002/eji.202451190)
- Burton, R. J. et al. 2024. Conventional and unconventional T cell responses contribute to the prediction of clinical outcome and causative bacterial pathogen in sepsis patients. Clinical & Experimental Immunology 216(3), pp. 293-306. (10.1093/cei/uxae019)
- Damani-Yokota, P. and Eberl, M. 2024. The γδ T Cell Club: bringing a global scientific community together in the age of Zoom. Immunology & Cell Biology 102(5), pp. 302-307. (10.1111/imcb.12742)
- Tyrrell, J. M., Ayanikkad, H. U., Nalleppilil-Gopakumar, V., Oyebode, R., Nmamdi Blessing, C., Hatch, S. and Eberl, M. 2024. Combining postgraduate research training, public engagement and primary school science education - A Superbugs Master (MSc) class. Frontiers in Microbiology (10.3389/fmicb.2024.1380045)
- Nollett, C., Eberl, M., Fitzgibbon, J., Joseph-Williams, N. and Hatch, S. 2024. Public involvement and engagement in scientific research and higher education: The only way is ethics?. Research Involvement and Engagement 10(1), article number: 50. (10.1186/s40900-024-00587-x)
- Leon-Lara, X. et al. 2024. γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis. Journal of Experimental Medicine 221(7), article number: e20231987. (10.1084/jem.20231987)
- Eberl, M. and Cruickshank, S. M. 2024. A culture shift to support public involvement and engagement in research. Journal of Experimental Medicine 221(6), article number: e20240268. (10.1084/jem.20240268)
- Tyler, C. J. et al. 2024. IL-21 conditions antigen-presenting human γδ T-cells to promote IL-10 expression in naïve and memory CD4+ T-cells. Discovery Immunology (10.1093/discim/kyae008)
- Tyrrell, J. et al. 2024. Superbugs online: co-production of an educational website to increase public understanding of the microbial world in, on and around us. Frontiers in Microbiology 15, article number: 1340350. (10.3389/fmicb.2024.1340350)
- Silva-Santos, B., Ribot, J. C., Adams, E. J., Willcox, B. E. and Eberl, M. 2023. γδ T cell explorations seek terra firma. Nature Immunology 24, pp. 1606-1609. (10.1038/s41590-023-01606-x)
- Eberl, M., Joseph-Williams, N., Nollett, C., Fitzgibbon, J. and Hatch, S. 2023. Overcoming the disconnect between scientific research and the public. Immunology and Cell Biology 101(7), pp. 590-597. (10.1111/imcb.12657)
- Cuff, S. et al. 2023. Inflammatory biomarker signatures in post-surgical drain fluid may detect anastomotic leaks within 48 hours of colorectal resection. Techniques in Coloproctology (10.1007/s10151-023-02841-y)
- Burton, R. J., Cuff, S. M., Morgan, M. P., Artemiou, A. and Eberl, M. 2023. GeoWaVe: Geometric median clustering with weighted voting for ensemble clustering of cytometry data. Bioinformatics 39(1), article number: btac751. (10.1093/bioinformatics/btac751)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Ponsford, M. J. et al. 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75(4), pp. 255-262. (10.1136/jclinpath-2020-207157)
- Tyrrell, J. M. et al. 2022. 'Superbugs': raising public awareness of antimicrobial resistance through a pop-up science shop. Research for All 6(1), pp. 1-21. (10.14324/RFA.06.1.06)
- Kaminski, H., Couzi, L. and Eberl, M. 2021. Unconventional T cells and kidney disease. Nature Reviews Nephrology 17, pp. 795-813. (10.1038/s41581-021-00466-8)
- Eberl, M., Oldfield, E. and Herrmann, T. 2021. Editor's Note: Relates to: 'Immuno-antibiotics: targeting microbial metabolic pathways sensed by unconventional T cells'. Immunotherapy Advances 1(1), article number: ltab023. (10.1093/immadv/ltab023)
- Burton, R. J., Ahmed, R., Cuff, S. M., Baker, S., Artemiou, A. and Eberl, M. 2021. CytoPy: An autonomous cytometry analysis framework. PLoS Computational Biology 17(6), article number: e1009071. (10.1371/journal.pcbi.1009071)
- Eberl, M., Oldfield, E. and Herrmann, T. 2021. Immuno-antibiotics: Targeting microbial metabolic pathways sensed by unconventional T cells. Immunotherapy Advances 1(1), article number: ltab005. (10.1093/immadv/ltab005)
- Cuff, S. M., Merola, J. P., Twohig, J. P., Eberl, M. and Gray, W. P. 2020. Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation. Brain Communications 2(2), article number: fcaa218. (10.1093/braincomms/fcaa218)
- Kouzeli, A. et al. 2020. CXCL14 preferentially synergizes with homeostatic chemokine receptor systems. Frontiers in Immunology 11, article number: 561404. (10.3389/fimmu.2020.561404)
- Goodlad, C. et al. 2020. Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis. Kidney International 97(6), pp. 1253-1259. (10.1016/j.kint.2020.01.044)
- Catar, R. A. et al. 2020. Control of neutrophil influx during peritonitis by transcriptional cross-regulation of chemokine CXCL1 by IL‐17 and IFN‐γ. Journal of Pathology 251(2), pp. 175-186. (10.1002/path.5438)
- Eberl, M. 2020. Antigen recognition by human γδ T cells: one step closer to knowing. Immunology and Cell Biology 98(5), pp. 351-354. (10.1111/imcb.12334)
- Raffray, L., Burton, R. J., Baker, S. E., Morgan, M. P. and Eberl, M. 2020. Zoledronate rescues immunosuppressed monocytes in sepsis patients. Immunology 159(1), pp. 88-95. (10.1111/imm.13132)
- Gadalla, A. A. M. et al. 2019. Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms. Scientific Reports 9(1), article number: 19694. (10.1038/s41598-019-55523-x)
- Nguyen, C. T., Maverakis, E., Eberl, M. and Adamopoulos, I. E. 2019. γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity. Seminars in Immunopathology 41(5), pp. 595-605. (10.1007/s00281-019-00752-5)
- Burton, R. J., Albur, M., Eberl, M. and Cuff, S. M. 2019. Using artificial intelligence to reduce diagnostic workload without compromising detection of urinary tract infections. BMC Medical Informatics and Decision Making 19(1), article number: 171. (10.1186/s12911-019-0878-9)
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9, article number: 10136. (10.1038/s41598-019-46585-y)
- Pottanat, N. D. et al. 2019. Analysis of the Ribonuclease a superfamily of antimicrobial peptides in patients undergoing chronic peritoneal dialysis. Scientific Reports 9, pp. -., article number: 7753. (10.1038/s41598-019-44219-x)
- Vermijlen, D., Gatti, D., Kouzeli, A., Rus, T. and Eberl, M. 2018. γδ T cell responses: How many ligands will it take till we know?. Seminars in Cell and Developmental Biology 84, pp. 75-86. (10.1016/j.semcdb.2017.10.009)
- Chakera, A., Mulroney, K., Shak, H., McGuire, A., Eberl, M. and Topley, N. 2018. Peritonitis in Peritoneal Dialysis patients: the case for rapid diagnosis, targeted treatment and monitoring to improve outcomes. European Medical Journal Nephrology 6, pp. 56-64.
- McCarthy, N. E. and Eberl, M. 2018. Human γδ T-cell control of mucosal immunity and inflammation. Frontiers in Immunology 9, article number: 985. (10.3389/fimmu.2018.00985)
- Rhodes, D. A. et al. 2018. Regulation of human γδ T cells by BTN3A1 protein stability and ATP-binding cassette transporters. Frontiers in Immunology 9, article number: 662. (10.3389/fimmu.2018.00662)
- Aufricht, C. et al. 2017. Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network. Kidney International 92(4), pp. 824-835. (10.1016/j.kint.2017.02.037)
- Chen, H. et al. 2017. Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells. Immunology and Cell Biology 95(7), pp. 620-629. (10.1038/icb.2017.21)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92(1), pp. 179-191. (10.1016/j.kint.2017.01.017)
- Howard, J. et al. 2017. The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection.. Journal of Infectious Diseases 215(10), pp. 1569-1579. (10.1093/infdis/jix149)
- Tyler, C. J., McCarthy, N. E., Lindsay, J. O., Stagg, A. J., Moser, B. and Eberl, M. 2017. Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin. The Journal of Immunology 198(9), article number: 1700003. (10.4049/jimmunol.1700003)
- Raby, A. et al. 2017. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology 28(2), pp. 461-478. (10.1681/ASN.2015080923)
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990)
- Johansson, M. A. et al. 2016. Probiotic lactobacilli modulate staphylococcus aureus-induced activation of conventional and unconventional T cells and NK cells. Frontiers in Immunology 7, article number: 273. (10.3389/fimmu.2016.00273)
- Morgan, M., Szakmany, T., Power, S., Olaniyi, P., Kathy, R., Hall, J. E. and Eberl, M. 2016. Sepsis patients with first and second-hit infections show different outcomes depending on the causative organism. Frontiers in Microbiology 7, article number: 207. (10.3389/fmicb.2016.00207)
- Liuzzi, A. R., McLaren, J. E., Price, D. and Eberl, M. 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36, pp. 31-37. (10.1016/j.coi.2015.06.002)
- Piggott, L., Omidvar, N., Martí Pérez, S., French, R., Eberl, M. and Clarkson, R. W. E. 2015. Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 17(1), pp. 96. (10.1186/s13058-015-0597-9)
- Bonneville, M. et al. 2015. Chicago 2014 – 30 years of γδ T cells. Cellular Immunology 296(1), pp. 3-9. (10.1016/j.cellimm.2014.11.001)
- Tyler, C. J., Doherty, D. G., Moser, B. and Eberl, M. 2015. Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system. Cellular Immunology 296(1), pp. 10-21. (10.1016/j.cellimm.2015.01.008)
- Rhodes, D. A. et al. 2015. Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. Journal of Immunology 194(5), pp. 2390-2398. (10.4049/jimmunol.1401064)
- Eberl, M., Friberg, I. M., Liuzzi, A. R., Morgan, M. and Topley, N. 2014. Pathogen-specific immune fingerprints during acute infection: The diagnostic potential of human γδ T-cells. Frontiers in Immunology 5, article number: 572. (10.3389/fimmu.2014.00572)
- Khan, M. W. A., Eberl, M. and Moser, B. 2014. Potential use of γδ T cell-based vaccines in cancer immunotherapy. Frontiers in Immunology 5, article number: 512. (10.3389/fimmu.2014.00512)
- Davey, M. S. et al. 2014. Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells. Journal of Immunology 193(7), pp. 3704-3716. (10.4049/jimmunol.1401018)
- Khan, M. W. A. et al. 2014. Expanded human blood-derived gamma delta T cells display potent antigen-presentation functions. Frontiers in Immunology 5, article number: 344. (10.3389/fimmu.2014.00344)
- Chen, H., Dieli, F. and Eberl, M. 2013. An unconventional TRAIL to cancer therapy. European Journal of Immunology 43(12), pp. 3159-3162. (10.1002/eji.201344105)
- Lin, C., Roberts, G. W., Kift-Morgan, A. P., Donovan, K., Topley, N. and Eberl, M. 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24(12), pp. 2002-2009. (10.1681/ASN.2013040332)
- Lin, C., Roberts, G. W., Kift-Morgan, A., Donovan, K. L., Topley, N. and Eberl, M. 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24(12), pp. 2002-2009. (10.1681/ASN.2013040332)
- Welton, J. L., Marti, S., Mahdi, M. H., Boobier, C., Barrett-Lee, P. and Eberl, M. 2013. γδ T cells predict outcome in zoledronate-treated breast cancer patients [Comment]. Oncologist 18(8), pp. E22-E23. (10.1634/theoncologist.2013-0097)
- Lin, C., Kift-Morgan, A. P., Moser, B., Topley, N. and Eberl, M. 2013. Suppression of pro-inflammatory T-cell responses by human mesothelial cells. Nephrology Dialysis Transplantation 28(7), pp. 1743-1750. (10.1093/ndt/gfs612)
- Welton, J. et al. 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28(3), pp. 464-471. (10.1002/jbmr.1797)
- Silva-Santos, B., Schamel, W. W. A., Fisch, P. and Eberl, M. 2012. gamma delta T-cell conference 2012: Close encounters for the fifth time. European Journal of Immunology 42(12), pp. 3101-3105. (10.1002/eji.201270101)
- Riganti, C., Massaia, M., Davey, M. S. and Eberl, M. 2012. Human γδ T-cell responses in infection and immunotherapy: Common mechanisms, common mediators?. European Journal of Immunology 42(7), pp. 1668-1676. (10.1002/eji.201242492)
- Heuston, S., Begley, M., Davey, M., Eberl, M., Casey, P. G., Hill, C. and Gahan, C. G. M. 2012. HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe. Microbiology 158(7), pp. 1684-1693. (10.1099/mic.0.056069-0)
- Bansal, R. R., Mackay, C. R., Moser, B. and Eberl, M. 2012. IL-21 enhances the potential of human gamma delta T cells to provide B-cell help. European Journal of Immunology 42(1), pp. 110-119. (10.1002/eji.201142017)
- Piggott, L., Omidvar, N., Marti-Perez, S., Eberl, M. and Clarkson, R. W. E. 2011. Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 13(5), article number: R88. (10.1186/bcr2945)
- Davey, M. S. et al. 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. Plos Pathogens 7(5), article number: e1002040. (10.1371/journal.ppat.1002040)
- Davey, M. S. et al. 2011. Failure to detect production of IL-10 by activated human neutrophils [Letter]. Nature Immunology 12(11), pp. 1017-1018. (10.1038/ni.2111)
- Moser, B. and Eberl, M. 2011. γδ T-APCs: a novel tool for immunotherapy? [Book Review]. Cellular and Molecular Life Sciences 68(14), pp. 2443-2452. (10.1007/s00018-011-0706-6)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
- Meuter, S., Eberl, M. and Moser, B. 2010. Prolonged antigen survival and cytosolic export in cross-presenting human γδ T cells. Proceedings of the National Academy of Sciences of the United States of America 107(19), pp. 8730-8735. (10.1073/pnas.1002769107)
- Meraviglia, S. et al. 2010. In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Clinical and Experimental Immunology 161(2), pp. 290-297. (10.1111/j.1365-2249.2010.04167.x)
- Brown, A. C., Eberl, M., Crick, D. C., Jomaa, H. and Parish, T. 2010. The nonmevalonate pathway of isoprenoid biosynthesis in mycobacterium tuberculosis is essential and transcriptionally regulated by dxs. Journal of Bacteriology 192(9), pp. 2424-2433. (10.1128/JB.01402-09)
- Eberl, M. and Moser, B. 2009. Monocytes and γδ T cells: close encounters in microbial infection. Trends in Immunology 30(12), pp. 562-568. (10.1016/j.it.2009.09.001)
- Eberl, M., Roberts, G. W., Meuter, S., Williams, J. D., Topley, N. and Moser, B. 2009. A rapid crosstalk of human gamma delta T cells and monocytes drives the acute inflammation in bacterial infections. Plos Pathogens 5(2), pp. 6-6., article number: e1000308. (10.1371/journal.ppat.1000308)
- Brandes, M. et al. 2009. Cross-presenting human gamma delta T cells induce robust CD8(+) alpha beta T cell responses. Proceedings of the National Academy of Sciences of the United States of America 106(7), pp. 2307-2312. (10.1073/pnas.0810059106)
- Dieli, F. et al. 2007. Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Research 67(15), pp. 7450-7457. (10.1158/0008-5472.can-07-0199)
- Vermijlen, D. et al. 2007. Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. The Journal of Immunology 178(7), pp. 4304-4314. (10.4049/jimmunol.178.7.4304)
- Moser, B. and Eberl, M. 2007. gammadelta T cells: novel initiators of adaptive immunity [review]. Immunological Reviews 215(1), pp. 89-102. (10.1111/j.1600-065x.2006.00472.x)
- Zafranskaya, M., Oschamnn, P., Engel, R., Weishaupt, A., van Noort, J. M., Jomaa, H. and Eberl, M. 2007. Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis. Immunology 121(1), pp. 29-39. (10.1111/j.1365-2567.2006.02518.x)
- Eberl, M., Wesch, D., Dieli, F. and Jomaa, H. 2006. Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells. Journal of Leukocyte Biology 79(4), pp. 663-6. (10.1189/jlb.1105640)
- Eberl, M., Jomaa, H., Pircher, H. and Fisch, P. 2005. Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1). Journal of leukocyte biology 77, pp. 67-70. (10.1189/jlb.0204096)
- Eberl, M., Beck, E., Christiansen, G. and Jamba, Z. 2004. Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so. Infection and Immunity 72(8), pp. 4881-3. (10.1128/IAI.72.8.4881-4883.2004)
- Eberl, M., Jomaa, H. and Hayday, A. C. 2004. Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells. Immunology 112(3), pp. 364-368. (10.1111/j.1365-2567.2004.01921.x)
- Begley, M., Gahan, C. G., Kollas, A. K., Hintz, M., Hill, C., Jomaa, H. and Eberl, M. 2004. The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. FEBS Letters 561(1-3), pp. 99-104. (10.1016/s0014-5793(04)00131-0)
- Ostrovsky, D. N., Dyomina, G. R., Deryabina, Y. I., Goncharenko, A. ., Eberl, M., Shumaev, A. and Shashkov, S. 2003. Properties of 2-C-Methyl-D-Erythritol 2,4-Cyclopyrophosphate, an intermediate in Nonmevalonate Isoprenoid Biosynthesis. Applied Biochemistry and Microbiology c/c of Prikladnaia Biokhimiia i Mikrobiologiia 39(5), pp. 497-502. (10.1023/A:1025452804046)
- Eberl, M. and Jomaa, H. 2003. A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens [letter]. Trends in Immunology 24(8), pp. 407-409. (10.1016/s1471-4906(03)00170-4)
- Eberl, M., Hintz, M., Reichenberg, A., Kollas, A. K., Wiesner, J. and Jomaa, H. 2003. Microbial isoprenoid biosynthesis and human gammadelta T cell activation [review]. FEBS Letters 544(1-3), pp. 4-10. (10.1016/s0014-5793(03)00483-6)
- Reichenberg, A. et al. 2003. Replacing the pyrophosphate group of HMB-PP by diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism. Biorganic and Medicinal Chemistry Letters 13(7), pp. 1257-1260. (10.1016/s0960-894x(03)00138-0)
- Kollas, A. K. et al. 2002. Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. FEBS Letters 532(3), pp. 432-436. (10.1016/s0014-5793(02)03725-0)
- Eberl, M., al-Sherbiny, M., Hagan, P., Ljubojevic, S., Thomas, A. W. and Wilson, R. A. 2002. A novel and sensitive method to monitor helminth infections by faecal sampling. Acta Tropica 83(2), pp. 183-187. (10.1016/s0001-706x(02)00089-x)
- Eberl, M., Engel, R., Beck, E. and Jomaa, H. 2002. Differentiation of human gamma-delta T cells towards distinct memory phenotypee. Cellular Immunology 218(1-2), pp. 1-6. (10.1016/s0008-8749(02)00519-1)
- Eberl, M. 2002. Don't count your interleukins before they've hatched [letter]. Trends in Immunology 23(7), pp. 341-342. (10.1016/s1471-4906(02)02239-1)
- Eberl, M. et al. 2002. Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology 106(2), pp. 200-211. (10.1046/j.1365-2567.2002.01414.x)
- Hintz, M. et al. 2001. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Letters 509(2), pp. 317-322. (10.1016/s0014-5793(01)03191-x)
- Eberl, M. et al. 2001. Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees. Infection and Immunity 69(9), pp. 5352-5362. (10.1128/iai.69.9.5352-5362.2001)
- Altincicek, B. et al. 2001. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS Letters 499(1-2), pp. 37-40. (10.1016/s0014-5793(01)02516-9)
- Eberl, M. et al. 2001. Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?. Journal of Infectious Diseases 183(8), pp. 1238-1247. (10.1086/319691)
- Atincicek, B. et al. 2001. Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. The Journal of Immunology 166(6), pp. 3655-3658. (10.4049/jimmunol.166.6.3655)
- Kasper, G. et al. 2001. A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins. The Journal of Immunology 23(3), pp. 141-152. (10.1046/j.1365-3024.2001.00366.x)
- Eberl, M., Beck, E., Coulson, P., Okamura, H., Wilson, R. A. and Mountford, A. P. 2000. IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigen. Vaccine 18(19), pp. 2002-2008. (10.1016/s0264-410x(99)00532-0)
- Jomaa, H. et al. 1999. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285(5433), pp. 1573-1576. (10.1126/science.285.5433.1573)
- Eberl, M., Mountford, A. P., Jankovic, D. and Beck, E. 1999. Isolation of T-cell antigens by using a recombinant protein library and its application to the identification of novel vaccine candidates against schistosomiasis. Infection and Immunity 67(7), pp. 3383-3389.
Websites
- Cuff, S. M., Merola, J. P., Eberl, M. and Gray, W. P. 2022. Presence of ventriculoperitoneal and lumbar shunts stimulate long lasting non-inflammatory changes in the cerebrospinal fluid distinct from the response to bacterial infection. [Online]. medRxiv. (10.1101/2022.10.12.22280998) Available at: https://doi.org/10.1101/2022.10.12.22280998
- Burton, R. J. et al. 2024. Conventional and unconventional T cell responses contribute to the prediction of clinical outcome and causative bacterial pathogen in sepsis patients. Clinical & Experimental Immunology 216(3), pp. 293-306. (10.1093/cei/uxae019)
- Tyrrell, J. et al. 2024. Superbugs online: co-production of an educational website to increase public understanding of the microbial world in, on and around us. Frontiers in Microbiology 15, article number: 1340350. (10.3389/fmicb.2024.1340350)
- Eberl, M., Joseph-Williams, N., Nollett, C., Fitzgibbon, J. and Hatch, S. 2023. Overcoming the disconnect between scientific research and the public. Immunology and Cell Biology 101(7), pp. 590-597. (10.1111/imcb.12657)
- Tyrrell, J. M. et al. 2022. 'Superbugs': raising public awareness of antimicrobial resistance through a pop-up science shop. Research for All 6(1), pp. 1-21. (10.14324/RFA.06.1.06)
- Goodlad, C. et al. 2020. Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis. Kidney International 97(6), pp. 1253-1259. (10.1016/j.kint.2020.01.044)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92(1), pp. 179-191. (10.1016/j.kint.2017.01.017)
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990)
- Rhodes, D. A. et al. 2015. Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. Journal of Immunology 194(5), pp. 2390-2398. (10.4049/jimmunol.1401064)
- Davey, M. S. et al. 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. Plos Pathogens 7(5), article number: e1002040. (10.1371/journal.ppat.1002040)
- Eberl, M., Roberts, G. W., Meuter, S., Williams, J. D., Topley, N. and Moser, B. 2009. A rapid crosstalk of human gamma delta T cells and monocytes drives the acute inflammation in bacterial infections. Plos Pathogens 5(2), pp. 6-6., article number: e1000308. (10.1371/journal.ppat.1000308)
- Vermijlen, D. et al. 2007. Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. The Journal of Immunology 178(7), pp. 4304-4314. (10.4049/jimmunol.178.7.4304)
- Hintz, M. et al. 2001. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Letters 509(2), pp. 317-322. (10.1016/s0014-5793(01)03191-x)
Ymchwil
Olion bysedd imiwnedd mewn haint acíwt
Mae diagnosio, trin ac atal haint yn wyneb lledaeniad byd-eang o ymwrthedd gwrthficrobaidd a risg gyson o bandemig dinistriol yn un o heriau mwyaf yr 21ain ganrif. Fodd bynnag, mae diffyg gwerthfawrogiad o hyd o sut mae'r corff yn synhwyro ac yn ymladd gwahanol fathau o bathogen.
Nod ein hymchwil yw archwilio a manteisio ar y digwyddiadau pathoffisiolegol sy'n sail i ymatebion llidiol pathogen-benodol at ddibenion diagnostig a therapiwtig. Mae'r system imiwnedd wedi esblygu i arolygu'r corff yn gyson am strwythurau a allai fod yn beryglus. Mae gwahanol bathogenau yn mynegi patrymau moleciwlaidd gwahanol ac felly'n rhyngweithio'n unigryw â chydrannau gwahanol o'r system imiwnedd. Felly, mae'r math o haint yn debygol o ennyn imiwnolegol gwahanol llofnodion, neu 'olion bysedd imiwnedd', y gellir eu hasesu'n feintiol ac yn ansoddol.
Enghraifft wych o'r gwahaniaethu hwn o wahanol bathogenau yw ymateboldeb unigryw celloedd T anghonfensiynol i metabolitau microbaidd cyffredin sy'n cael eu rhannu gan lawer o bathogenau bacteriol ond sy'n absennol o gelloedd dynol. Mae celloedd T γδ a chelloedd MAIT yn cael eu tynnu'n gyflym i safleoedd haint acíwt, lle byddant yn dod ar draws microbau goresgynnol yng nghyd-destun celloedd imiwnedd eraill, niwtroffilau a monocytau yn bennaf, a'r meinwe o'i amgylch.
Mae ein canfyddiadau'n dangos y bydd y rhyngweithio hwn yn denu celloedd effaith pellach, yn gwella gweithgaredd celloedd scavenger ac yn hyrwyddo datblygiad imiwnedd microbau-benodol. Fodd bynnag, os caiff ei sbarduno ar yr adeg anghywir neu'r safle anghywir, gall yr adwaith hwn arwain at niwed sy'n gysylltiedig â llid ac effeithio ar ganlyniadau cleifion. Mae'r celloedd T anghonfensiynol yn canolbwyntio ar drefnu rhaeadrau llidiol mewn heintiau microbaidd yn nodi'r celloedd hyn fel prif dargedau ar gyfer triniaethau a diagnosteg newydd.
Rydym yn anelu at ddiffinio llofnodion pathogen-benodol lleol a systemig o biofarcwyr imiwnedd hydawdd a chellog mewn clefydau lle mae ymyrraeth gynnar a thargedu yn allweddol a lle bydd canlyniadau clinigol yn elwa o ddiagnosteg gwell a chynharach. Ar gyfer hyn, rydym yn astudio unigolion sy'n cyflwyno cyflyrau acíwt fel peritonitis, sepsis difrifol, haint llwybr wrinol a ventriculitis, mewn cydweithrediad â chlinigwyr, microbiolegwyr, ystadegwyr, gwyddonwyr cyfrifiadurol a phartneriaid masnachol.
Aelodau'r grŵp presennol a'r gorffennol
- Kirsty Emery, Myfyriwr PhD 2023–
- Jennifer Waterman, Myfyriwr PhD 2024–
- Kate Davies, Myfyriwr PhD (cyd-oruchwylydd) 2022–
- Siva Oruganti, Myfyriwr PhD (cyd-oruchwylydd) 2024–
- Daniel Griffiths, Myfyriwr MPhil 2023–
- Emily Pockett, Myfyriwr MSc 2025
- Aaron Bolitho, Uwch Dechnegydd 2024–
- Lila-blythe Maros, Myfyriwr Interniaeth 2025
- Georgina Sparling, Myfyriwr Interniaeth 2025
- Raya Ahmed, Ôl-ddoethurol 2016-2019
- Sarah Baker, Cynorthwy-ydd Ymchwil 2018-2021
- Josephine Banda, Myfyriwr MSc (cyd-oruchwylydd) 2023
- Raj Bansal, Myfyriwr PhD 2007-2012
- Amy Brook, Myfyriwr PhD 2015-2019
- Ross Burton, Myfyriwr PhD 2018-2022
- Hung-Chang Chen, Myfyriwr PhD 2011-2016
- Chantal Colmont, Cynorthwyydd Ymchwil 2013-2014
- Friday Cox, Myfyriwr Interniaeth 2024
- Simone Cuff, Ôl-ddoethurol 2017-2022
- Martin Davey, Myfyriwr PhD/Ôl-ddoethurol 2008-2013
- Kashia Dias, Myfyriwr Interniaeth 2024
- Nicholas Graves, Hyfforddai SFP2 2024-2025
- Ida Jackson (Friberg), Ôl-ddoethuriaeth 2013-2015
- Emily Jacob, Myfyriwr MPhil (cyd-oruchwylydd) 2020-2022
- Maximilian Keisker, Myfyriwr Erasmus 2017
- Ariadni Kouzeli, Myfyriwr PhD (cyd-oruchwylydd) 2015-2020
- Ann Kift-Morgan, Cynorthwy-ydd Ymchwil 2011-2018
- Jack Leyshon, Uwch Dechnegydd 2024
- Chan-Yu Lin, Myfyriwr PhD 2009-2012
- Anna Rita Liuzzi, myfyriwr PhD/Ôl-ddoethurol 2013-2016
- Christophe Macri, Myfyriwr Interniaeth 2009
- Salvador Martí Pérez, Ôl-ddoethurol 2009-2010
- Oliwia Michalak, Myfyriwr PhD 2018-2020
- Linda Moet, Myfyriwr PhD (cyd-oruchwylydd) 2018-2022
- Matt Morgan, Myfyriwr PhD (cyd-oruchwylydd) 2011-2014
- Luke Piggott, Myfyriwr PhD (cyd-oruchwylydd) 2009-2012
- Loic Raffray, Cymrawd Marie Curie yr UE 2017-2018
- Nicola Reeves, Myfyriwr MD (cyd-oruchwylydd) 2019-2021
- Al-Motaz Rizek, Myfyriwr MSc (cyd-oruchwylydd) 2024
- Teja Rus, Myfyriwr PhD (cyd-oruchwylydd) 2015-2020
- Michele Scotto di Mase, Myfyriwr Interniaeth 2015
- Yasmin Shanneik, Myfyriwr Erasmus 2014-2015
- Lucy Sheikh, Myfyriwr MSc (cyd-oruchwylydd) 2023
- Katie Stanswood, Myfyriwr MSc (cyd-oruchwylydd) 2022
- Chris Tyler, Myfyriwr PhD 2012-2016
- Joanne Welton, Ôl-ddoethurol 2011-2013
- Jingjing Zhang, Ôl-ddoethurol 2015-2016
Cymorth grant
2024-2026
Cymdeithas Llawfeddygon Prydain Fawr, ASGBI a Gwobr Ymchwil Llawfeddygol GUTS UK
"Canfod gollyngiad anastomotig yn gynnar ar ôl llawdriniaeth colorectol gan ddefnyddio biofarcwyr hydawdd ac nad ydynt yn hydawdd mewn hylif peritoneal"
Cyd-ymgeisydd (Prif ymgeisydd: Jennifer Waterman; cyd-ymgeiswyr Yr Athro Jared Torkington, Dr. Nicola Reeves, Dr. Natalie Joseph-Williams)
£ 10,000 (24 mis)
2024-2025
Rhaglen Hyfforddiant Academaidd Addysg a Gwella Iechyd Cymru (i Nick Graves)
"Rhagfynegi gollyngiadau anastomotig mewn cleifion ar ôl llawdriniaeth colorectol"
Prif Ymgeisydd (cyd-ymgeisydd: Dr. Nicola Reeves)
(12 mis)
2023-2025
Ymchwil Iechyd a Gofal Cymru, Grant Ymchwil Iechyd
"Canfod gollyngiad anastomotig yn gynnar ar ôl llawdriniaeth colorectol"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Jared Torkington, Dr. Nicola Reeves, Dr. Natalie Joseph-Williams, Dr. Rachel Morris, Dr. Susan Campbell)
£ 145,684 (24 mis)
2023-2027
GW4 MRC DTP PhD Ysgoloriaeth (i Kirsty Emery)
"Rheoli imiwnedd mwcosa ac uniondeb coluddyn gan gelloedd T γδ dynol" (48 mis)
Prif Ymgeisydd (cyd-ymgeiswyr: Dr. Neil McCarthy, Dr. Gareth Jones)
tua £ 100,000 (48 mis)
2023-2026
Ysgoloriaeth PhD Hwb Ymchwil Canser Prifysgol Caerdydd (i Daniel Griffiths)
"Offer newydd ar gyfer dadansoddi data cytometreg dimensiwn uchel – goblygiadau ar gyfer imiwnoleg canser ac imiwnotherapi"
Prif Ymgeisydd (cyd-ymgeiswyr: Dr. Andreas Artemiou, Yr Athro Awen Gallimore)
£ 81,728 (36 mis)
2022-2026
Ysgoloriaeth PhD DTP MRC GW4 (i Kate Davies)
"Atal imiwnedd celloedd T a chynhyrchu gwrthgyrff yn ystod haint firws a sepsis"
Cyd-ymgeisydd (Prif ymgeisydd: Dr. James McLaren; cyd-ymgeisydd: Dr. Gareth Jones)
tua £ 100,000 (48 mis)
2022
Rhaglen Sbrint Llywodraeth Cymru
"Diagnosis a prognosis wedi'i arwain gan ddeallusrwydd artiffisial o sepsis ôl-lawdriniaethol"
Prif Ymgeisydd
£ 31,781
2021-2022
Ymchwil Iechyd a Gofal Cymru, Grant Ymchwil Iechyd
"Epidemioleg ac effaith heintiau eilaidd bacteriol ac ymwrthedd gwrthficrobaidd ar Gofal Dwys yn ystod pandemig SARS-CoV-2"
Cyd-ymgeisydd (Prif ymgeisydd: Dr. Lim Jones; gyda Dr. Mandy Wootton, Dr. James McLaren, Yr Athro Thomas Connor, Dr. Matt Morgan, Dr. Matt Wise, Dr. Harriet Hughes, Dr. Brendan Healey, Dr. Brad Spiller)
£ 74,000 (12 mis)
2021
Gwobr Partneriaeth Drosiadol Sefydliadol Ymddiriedolaeth Wellcome (ITPA)
"Diagnosis a prognosis sy'n seiliedig ar feddyginiaeth fanwl o sepsis ôl-lawdriniaethol"
Prif Ymgeisydd (gyda'r Athro Jared Torkington, Dr. Nicola Reeves, Dr. Matt Morgan, Dr. Andreas Artemiou, Dr. Simone Cuff, Ross Burton)
£19,969 (4 mis)
2019-2021
Prosiect CYFLYMU
"Diagnosis sy'n seiliedig ar feddyginiaeth fanwl o gymhlethdodau ôl-lawfeddygol mewn claf sy'n cael llawdriniaeth abdomenol"
Prif Ymgeisydd (gyda'r Athro Ian Weeks, yr Athro Jared Torkington, Dr. Rachel Morris)
£ 468,913 (18 mis)
2019-2020
Gwobr Drawsddisgyblaethol ISSF3 Ymddiriedolaeth Wellcome
"Canfod haint niwrolegol sy'n peryglu bywyd yn gyflym trwy ganfod olion bysedd imiwnedd mewn hylif cerebrospinal"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro William Gray, Dr. Andreas Artemiou, Dr. Simone Cuff, Mr. Joseph Merola)
£ 49,996 (12 mis)
2018-2021
Cymrodoriaeth Meddygaeth Fanwl Cronfa Datblygu Rhanbarthol Ewrop Sêr Cymru II (i Dr. Tom Penfro)
"Olion bysedd imiwnedd heintiau bacteriol mewn sirosis"
Cyd-ymgeisydd (gyda'r Athro Andrew Godkin)
£ 185,000 (36 mis)
2018-2022
Ysgoloriaeth PhD DTP GW4 (i Oliwia Michalak)
"Olion bysedd imiwnedd dan arweiniad dysgu peirianyddol ar gyfer canfod haint sy'n peryglu bywyd yn gyflym mewn sirosis yr afu
Prif Ymgeisydd (cyd-ymgeiswyr: Dr. Tom Pembroke, Dr. Andreas Artemiou):
tua £ 80,000 (42 mis)
2018-2021
Ysgol Meddygaeth PhD Ysgoloriaeth (i Ross Burton)
"Olion bysedd imiwnedd systemig mewn cleifion â sepsis difrifol acíwt"
Prif Ymgeisydd (cyd-ymgeiswyr: Dr. Andreas Artemiou, Dr. Matt Morgan, Yr Athro Peter Ghazal):
tua £ 60,000 (36 mis)
2018
Gwobr Drawsddisgyblaethol ISSF3 Ymddiriedolaeth Wellcome
"Olion bysedd imiwnedd mewn cleifion haemodialysis â haint acíwt"
Prif Ymgeisydd (gyda Dr. Soma Meran, Dr. Matt Morgan, Dr. Simone Cuff, Dr. Andreas Artemiou, Yr Athro Donald Fraser)
£ 49,955 (12 mis)
2017-2018
EU Horizon 2020, Cymrodoriaeth Unigol Marie Skłodowska-Curie (i Dr. Loic Raffray)
"Celloedd T tebyg i gynhenid mewn sepsis (ILTIS): Goblygiadau ar gyfer diagnosis cynnar ac achub atal imiwnedd"
Prif oruchwyliwr (cyd-oruchwyliwr Dr. Matt Morgan)
UE € 97,727 (12 mis)
2017
Cynllun Agosrwydd at Ddarganfod MRC (Catalydd Biofeddygol)
"Canfod a nodweddu heintiau niwrolegol sy'n peryglu bywyd yn gyflym"
Cyd-ymgeisydd (Prif ymgeisydd: Yr Athro Ian Weeks; cyd-ymgeisydd: Yr Athro William Gray)
£ 24,161 (6 mis)
2017
Cronfa Bontio Gwyddorau Bywyd Cymru, Grant Pathfinder
"Datblygu profion diagnostig cyflym in vitro ar gyfer canfod a nodweddu haint yn gynnar"
Cyd-ymgeisydd (Prif ymgeisydd: Yr Athro Ian Weeks; cyd-ymgeiswyr: Yr Athro Nicholas Topley, Dr. Fraser Logue)
£ 74,554 (12 mis)
2016-2019
Grant ymchwil MRC
"Synhwyro pathogen cynhenid gan gelloedd T anghonfensiynol lleol yn ystod heintiau microbaidd"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Donald Fraser, Yr Athro David Price, Dr. Kristin Ladell, Yr Athro Phil Taylor, Yr Athro Jamie Rossjohn)
£ 660,663 (36 mis)
2016-2019
Ymchwil Iechyd a Gofal Cymru, Gwobr Amser Ymchwil Glinigol (i Dr. Matt Morgan)
Goruchwyliwr Academaidd
£ 66,535 (36 mis)
2016
Gwobr Hadau ISSF Ymddiriedolaeth Wellcome
"γδ T-cell-mediated polarization of CD4+ T-cell responses: implications for Crohn's disease"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Bernhard Moser, Dr. Andrew Stagg, Dr. James Lindsay)
£ 34,000 (6 mis)
2016
Cymrodoriaeth Ymweld Newydd Caerdydd (i'r Athro Thomas Herrmann)
Prif Ymgeisydd
£ 5,500 (3 mis)
2015-2018
MRC PhD Ysgoloriaeth (i Amy Brook)
"Llofnodion microRNA pathogen-benodol yn ystod haint peritoneal acíwt"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Donald Fraser, Dr. Timothy Bowen)
£ 60,000 (36 mis)
2015-2018
MRC PhD Ysgoloriaeth (i Ariadni Kouzeli)
"Defnyddio T-APCs gama / delta dynol mewn imiwnedd gwrth-tiwmor"
Cyd-ymgeisydd (Prif ymgeisydd: Yr Athro Bernhard Moser; cyd-ymgeisydd: Yr Athro Andrew Godkin)
£ 60,000 (36 mis)
2015-2018
Tenovus PhD Ysgoloriaeth (i Teja Rust)
"Gamma / delta T-APCs dynol: Prosesu antigenau tiwmor ac ymsefydlu imiwnedd gwrth-tiwmor"
Cyd-ymgeisydd (Prif ymgeisydd: Yr Athro Bernhard Moser; cyd-ymgeisydd: Yr Athro Awen Gallimore)
£ 89,780 (36 mis)
2015-2018
Ymchwil Iechyd a Gofal Cymru, grant prosiect Canolfan Ymchwil Canser Cymru
"Modelau cyn-glinigol ar gyfer imiwnotherapïau newydd"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Awen Gallimore, Yr Athro Bernhard Moser, Yr Athro Andrew Godkin, Dr. Ann Ager)
£ 110,000 (36 mis)
2015-2020
Ymchwil Iechyd a Gofal Cymru
"Uned Ymchwil Arennau Cymru"
Cyd-ymgeisydd (Prif Ymgeisydd: Yr Athro Donald Fraser; gyda chyd-ymgeiswyr ar draws Caerdydd, Casnewydd, Abertawe a Bangor)
£ 2,000,000 (60 mis)
2015-2016
Ymchwil Arennau'r DU, Grant Prosiect
"Canfod haint yn gyflym a gwella goroesi mewn cleifion dialysis: rôl ymatebion llidiol anghonfensiynol sy'n cael eu gyrru gan gelloedd T"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Nicholas Topley, Yr Athro Bernhard Moser, Dr. Kieron Donovan, Yr Athro Donald Fraser)
£ 199,218 (24 mis)
2014-2015
MRC-Cynllun Hyder mewn Cysyniad (Catalydd Biofeddygol)
"Diagnosis pwynt gofal o sepsis acíwt"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Nicholas Topley, Yr Athro Paul Davis, Dr. Peter Morgan, Dr. Tamas Szakmany, Dr. Matt Morgan)
£ 44,935 (12 mis)
2014
Cynghrair Ymchwil Drosiadol Severnside (SARTRE), Gwobr Prosiect Her Technoleg Iechyd
"Diagnosis pwynt gofal o heintiau llif gwaed"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Nicholas Topley, Yr Athro Judith Hall, Yr Athro Paul Davis)
£ 24,912 (6 mis)
2014
Cymdeithas Imiwnoleg Prydain
Gwobrau Teithio BSI i Chris Tyler, Hung-Chang Chen, Matt Morgan a Matthias Eberl
Cynhadledd Cell T gamma/delta yn Chicago, UDA, 16-18 Mai 2014
£ 4,000
2013-2016
Rhwydwaith Hyfforddiant Cychwynnol Marie Curie FP7 yr UE, ITN 287813
"Hyfforddiant ac Ymchwil Ewropeaidd mewn Dialysis Peritoneal (EuTRiPD)"
Goruchwyliwr PhD (mewn cydweithrediad â chanolfannau academaidd yn Amsterdam, Berlin, Caerdydd, Heidelberg, Madrid, Poznan, Strasbwrg, Fienna; partneriaid diwydiannol: Zytoprotect, Baxter, Abbott; a Dutch Kidney Foundation, Kidney Research UK, EuroPD)
UE € 3,140,988 i gyd; € 517,568 o'r rhain i Brifysgol Caerdydd (48 mis)
2013-2016
Gwobr Datblygu Cynnyrch Cyfnod Cynnar Dyfeisio ar gyfer Arloesi NIHR (i4i)
"Profion cyflym, anfewnwthiol ar gyfer heintiau bacteriol acíwt yn seiliedig ar olion bysedd imiwnedd penodol pathogen"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Nicholas Topley, Yr Athro Ian Weeks, Yr Athro Chris Butler, Dr. Eryl Cox, Yr Athro Paul Davis)
£ 421,961 (30 mis)
2013-2014
NISCHR/Ymddiriedolaeth Wellcome ISSF Seedcorn/Grant Dichonoldeb
"Defining pathogen-specific responses in acute infection: development of point-of-care tests for bacterial identification"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Nicholas Topley, Dr. Kieron Donovan, Dr. Julian Marchesi, Dr. James Chess)
£ 49,972 (12 mis)
2013
Galwad Offer Cydweithredu Gwyddorau Iechyd Academaidd NISCHR
Cyd-ymgeisydd (prif ymgeisydd: Dr. Kieron Donovan)
£ 5,000
2013
Cancer Research UK, Cronfa Datblygu Canolfan CR-UK Caerdydd
"Goresgyn ymwrthedd bôn-gelloedd canser y fron i imiwnotherapïau newydd"
Prif Ymgeisydd (cyd-ymgeiswyr: Dr. Richard Clarkson, Hung-Chang Chen)
£ 4,950 (12 mis)
2012-2015
Ysgoloriaeth PhD MRC (i Chris Tyler)
"Rheoli ymatebion celloedd T alffa / beta gan T-APCs gama / delta dynol"
Prif Ymgeisydd (cyd-ymgeisydd: Yr Athro Bernhard Moser)
£ 60,000 (36 mis)
2012
Cymdeithas Imiwnoleg Prydain
Gwobrau Teithio BSI i Martin Davey, Joanne Welton a Chan-Yu Lin
Cynhadledd Cell T gamma/delta yn Freiburg, yr Almaen, 31 Mai-2 Mehefin 2012
£ 2,100
2011-2015
Tenovus PhD Ysgoloriaeth (i Hung-Chang Chen)
"Celloedd T gama / delta dynol ar gyfer imiwnotherapi canser y fron"
Prif Ymgeisydd (cyd-ymgeisydd: Dr. Richard Clarkson)
£ 89,993 (45 mis)
2010-2013
Llywodraeth Cynulliad Cymru, Gwobr Ymchwil Iechyd
"Gwella canlyniadau cleifion o heintiau sy'n gysylltiedig â dialysis peritoneal"
Prif gyd-ymgeisydd (Prif ymgeisydd: Dr. Gareth Roberts; cyd-ymgeiswyr: Yr Athro Nicholas Topley, Yr Athro Aled Phillips)
£ 207,325 (45 mis)
2010
Ymddiriedolaeth Wellcome, Ysgoloriaeth Gwyliau Biofeddygol (i Sarah Rollason)
"Celloedd T gamma/delta ar gyfer imiwnotherapi canser"
Prif ymgeisydd
£ 1,080 (6 wythnos)
2010
Cancer Research UK, Cronfa Datblygu Canolfan CR-UK Caerdydd
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Malcolm Mason, Yr Athro Peter Barrett-Lee)
£ 4,940 (9 mis)
2010
Cymdeithas Imiwnoleg Prydain
Gwobrau Teithio BSI i Raj Bansal, Martin Davey
Cynhadledd Cell T gamma/delta yn Kiel, yr Almaen, 19-21 Mai 2010
£ 1,000
2009-2013
Baxter Healthcare, Darganfyddiadau Arennol Grant Allanol
"Celloedd T, monocytes a niwtroffilau: croessiarad niweidiol mewn haint sy'n gysylltiedig â dialysis peritoneal"
Prif Ymgeisydd (cyd-ymgeisydd: Yr Athro John D. Williams)
US $ 374,947 (48 mis)
2009-2012
Cancer Research UK, Grant Prosiect
"Plastigrwydd swyddogaethol celloedd T gamma/delta a'u hecsbloetio mewn therapi canser"
Prif Ymgeisydd (cyd-ymgeiswyr: Yr Athro Malcolm Mason, Yr Athro Peter Barrett-Lee)
£ 170,067 (42 mis)
2009-2010
Ymgyrch Canser y Fron, Grant Peilot Bach
"Rôl TRAIL mewn cytotoxicity cyfryngu celloedd T gama / delta dynol tuag at gelloedd canser y fron"
Prif Ymgeisydd (cyd-ymgeisydd: Dr. Richard Clarkson)
£ 19,944 (12 mis)
2008-2010
Llywodraeth Cynulliad Cymru, Gwobr Partneriaeth Ymchwil Iechyd MRC
"Rôl celloedd T mewn llid a haint sy'n gysylltiedig â dialysis peritoneal"
Prif Ymgeisydd (cyd-ymgeisydd: Yr Athro Nicholas Topley)
£ 209,660 (27 mis)
2007-2010
Ysgoloriaeth MRC (i Raj Bansal)
"Cymorth celloedd B a ddarperir gan gelloedd T gama / delta dynol"
Prif Ymgeisydd (cyd-ymgeisydd: Yr Athro Bernhard Moser)
£ 55,050 (36 mis)
2007-2011
Cynghorau Ymchwil y DU
Cymrodoriaeth RCUK mewn Ymchwil Drosiadol mewn Meddygaeth Arbrofol
£ 125,000 (60 mis)
2007
Ymddiriedolaeth Wellcome, Gwobr 'Gwerth mewn Pobl'
"Celloedd mewn pontio ymatebion imiwnedd cynhenid ac addasol"
Prif Ymgeisydd (cyd-ymgeisydd: Yr Athro Paul Morgan)
£ 34,786 (12 mis)
Addysgu
Er mwyn goresgyn cymhlethdod anhygoel y system imiwnedd a'i wasgu'n ddarnau y gellir eu treulio, mae addysgu imiwnoleg yn aml mewn perygl o or-symleiddio senarios a / neu ddilyn ffasiynau dros dro. Y prif heriau yw cadw i fyny â'r llenyddiaeth ddiweddaraf ac ymgorffori datblygiadau diweddar yn y gwersi; i gludo brwdfrydedd rhywun am wyddoniaeth i'r myfyrwyr; i ddangos y gall hyd yn oed y mecanweithiau mwyaf cymhleth fod yn berthnasol clinigol enfawr mewn iechyd a chlefydau; a mynd i'r afael â myfyrwyr â dulliau safonol mewn labordai diagnostig ac ymchwil, ond hefyd i'w gwneud yn ymwybodol o bosibiliadau technoleg fodern. Fy nod yw addysgu myfyrwyr meddwl agored a beirniadol sy'n cael yr holl offer gwyddonol ond rhyngbersonol sydd eu hangen i allu cwestiynu safbwyntiau cyfoes a datrys problemau newydd.
Rwyf wedi ymrwymo i gefnogi'r cwricwlwm meddygol C21 drwy addysgu, dysgu a diweddaru proffesiynol. Rwy'n cyfrannu at addysgu grwpiau bach effeithiol ym modwl Blwyddyn 2 SSC "Imiwnoleg Ryngweithiol" bob blwyddyn ac ar gyfer adolygiadau llenyddiaeth SSC Blwyddyn 1, ac rwyf wedi dysgu mewn modiwlau ar imiwnopatholeg/imiwnotherapiwteg ac ar fiomarcwyr/diagnosteg i Flwyddyn 3 a myfyrwyr rhyng-gyfrifedig, ac wedi rhoi tiwtorialau grŵp bach i fyfyrwyr Blwyddyn 1. Rwyf hefyd yn cymryd rhan yn yr MSc "Imiwnoleg Glinigol Gymhwysol ac Arbrofol", ac ers 2010 rwyf wedi bod yn gweithredu fel Tiwtor/Mentor Academaidd Personol ar gyfer israddedigion meddygol.
Rwyf wedi hyfforddi a mentora myfyrwyr israddedig ac ôl-raddedig yn y labordy, gan gynnwys profiad gwaith a myfyrwyr haf, a myfyrwyr interniaeth o Ffrainc a'r Almaen, ac wedi hyfforddi myfyrwyr PhD o'r DU, yr Eidal, Gwlad Groeg, Slofenia, yr Iseldiroedd, Gwlad Pwyl a Taiwan yn fy labordy. Rwyf wedi goruchwylio un ar ddeg a chyd-oruchwylio pum myfyriwr PhD arall, pob un ohonynt wedi cwblhau, neu ar y trywydd iawn, eu PhD o fewn pedair blynedd.
Rwyf wedi gwasanaethu ar y paneli arfarnu blynyddol ar gyfer myfyrwyr PhD a MD >50 ers 2014, ac rwyf wedi cael fy mhenodi'n arholwr mewnol a chadeirydd viva traethodau ymchwil PhD ym Mhrifysgol Caerdydd ac fel arholwr allanol traethodau ymchwil PhD yn y DU, Iwerddon, Awstria, Ffrainc, Gwlad Belg, yr Eidal a Phortiwgal.
Bywgraffiad
Proffil gyrfa
- Ers 2018
Athro Imiwnoleg Drosiadol, Is-adran Heintiau ac Imiwnedd, Ysgol Meddygaeth, Prifysgol Caerdydd
- 2015-2018
Darllenydd, Is-adran Heintiau ac Imiwnedd, Ysgol Meddygaeth, Prifysgol Caerdydd
- 2011-2015
Uwch Ddarlithydd, Sefydliad Heintiau ac Imiwnedd Caerdydd, Ysgol Meddygaeth, Prifysgol Caerdydd
- 2007-2011
Cymrawd RCUK mewn Ymchwil Drosiadol mewn Meddygaeth Arbrofol, Ysgol Meddygaeth, Prifysgol Caerdydd
- 2005-2006
Postdoc, Sefydliad Bioleg Celloedd, Prifysgol Bern (Y Swistir)
Lab: Yr Athro Bernhard Moser
- 2000-2005
Postdoc, Sefydliad Biocemeg, Ysgol Meddygaeth, Prifysgol Giessen (Yr Almaen)
Lab: Dr Hassan Jomaa
- 1998-2000
Postdoc, Adran Bioleg, Prifysgol Efrog (DU)
Lab: Yr Athro Alan Wilson
- 1995-1998
Myfyriwr PhD, Sefydliad Biocemeg, Ysgol Meddygaeth, Prifysgol Giessen (Yr Almaen)
Lab: Yr Athro Ewald Beck
Anrhydeddau a dyfarniadau
- 2015: Promotion to Reader, Cardiff University
- 2011: Promotion to Senior Lecturer, Cardiff University
- 2009: Best Free Communications Prize at 9th European Peritoneal Dialysis Meeting, Strasbourg, France
- 2007: RCUK Fellowship in Translational Research in Experimental Medicine
- 2007: Wellcome Trust 'VIP' Award
- 1995: PhD Studentship, "Graduiertenkolleg Molekulare Biologie und Pharmakologie", German Research Foundation (DFG)
Aelodaethau proffesiynol
- British Society for Immunology (BSI):
BSI Board of Trustees since Jan 2017,
BSI Forum 2009-2016,
Chairman of the BSI South Wales Immunology Group 2007-2015
- German Society for Immunology (DGfI)
Pwyllgorau ac adolygu
Rolau arwain
- ers 2020: Arweinydd Academaidd ar y Cyd ar gyfer Cynnwys ac Ymgysylltu â'r Cyhoedd, Ysgol Meddygaeth, Prifysgol Caerdydd
- ers 2015: Arweinydd Ymgysylltu, Sefydliad Ymchwil Imiwnedd Systemau, Prifysgol Caerdydd
- ers 2014: Cadeirydd Paneli Arfarnu PhD, Haint ac Imiwnedd, Prifysgol Caerdydd
- ers 2011: Sylfaenydd a Gweinyddwr, Fforwm Cell T
- ers 2009: Golygydd Gwe, Haint ac Imiwnedd, Prifysgol Caerdydd
Arholwr PhD
- Prifysgol Caerdydd
- Coleg y Brenin Llundain
- Coleg y Drindod Dulyn, Iwerddon
- Prifysgol Genedlaethol Iwerddon, Maynooth
- Prifysgol Antwerp, Gwlad Belg
- Prifysgol Bordeaux, Ffrainc
- Université Libre de Bruxelles, Gwlad Belg
- Prifysgol Lisbon, Portiwgal
- Prifysgol Palermo, Yr Eidal
- Prifysgol Stockholm, Sweden
- Prifysgol Feddygol Fienna, Awstria
Adolygydd i gyrff cyllido
- AERES - Asiantaeth Gwerthuso ar gyfer Ymchwil ac Addysg Uwch, Ffrainc
- ATIP-Avenir (CNRS / Inserm), Ffrainc
- Barts and The London Charity, UK
- BBSRC - Cyngor Ymchwil Biotechnoleg a Gwyddorau Biolegol, y DU
- Boehringer Ingelheim Fonds, Yr Almaen
- Breast Cancer Now, UK
- Cancer Research UK
- Crohn's in Childhood Research Association (CICRA), UK
- Crohn's and Colitis UK
- Deutsche Forschungsgemeinschaft (DFG), Yr Almaen
- Cymdeithas Canser yr Iseldiroedd (KWF), Yr Iseldiroedd
- Cyngor Ymchwil yr Iseldiroedd (NWO), Yr Iseldiroedd
- Cyngor Ymchwil Ewropeaidd (ERC)
- Sefydliad Gwyddoniaeth Ewrop (ESF)
- Fondation pour la Recherche Médicale, Ffrainc
- Sefydliad German-Israel ar gyfer Ymchwil Gwyddonol a Datblygu
- Institut National du Cancer (INCa), Ffrainc
- Kay Kendall Leukaemia Fund, UK
- Kidney Research UK
- Cronfa Her Ymchwil a Datblygu Partneriaid Iechyd King's, UK
- MRC - Cyngor Ymchwil Feddygol, y DU
- Y Weinyddiaeth Wyddoniaeth, Technoleg a Gofod, Israel
- Multiple Sclerosis Society, UK
- Y Ganolfan Genedlaethol ar gyfer Disodli, Mireinio a Lleihau Anifeiliaid mewn Ymchwil (NC3Rs), UK
- Y Sefydliad Cenedlaethol ar gyfer Ymchwil Iechyd (NIHR), UK
- Cyngor Ymchwil Norwy
- Cyngor Grantiau Ymchwil, Hong Kong
- Coleg Prifysgol Cork, Iwerddon
- Fonds de la Recherche Scientifique, Gwlad Belg
- Prifysgol Liège, Gwlad Belg
- Wellcome Trust, UK
- Sefydliad Wilhelm Sander, Yr Almaen
Adolygydd ar gyfer cyfnodolion gwyddonol
- American Journal of Physiology – Ffisioleg Arennol
- Gwaed
- Asgwrn
- BMC imiwnoleg
- Ymchwil Canser y Fron
- Imiwnoleg Canser Imiwnotherapi
- Ymchwil Canser
- Carcinogenesis
- Biocemeg Cell & Function
- Adroddiadau Cell
- Imiwnoleg Cellog
- Chronobiology International
- Ymchwil Canser Clinigol
- Imiwnoleg Glinigol a Datblygiadol
- Imiwnoleg Glinigol ac Arbrofol
- Meddygaeth Glinigol ac Arbrofol
- Cyfathrebu Bioleg
- Targedau Cyffuriau Canser Cyfredol
- Adolygiadau Imiwnoleg Cyfredol
- Cytokine
- Imiwnoleg Darganfod
- EBioMedicine
- Adroddiadau EMBO
- European Journal of Clinical Microbiology & Infectious Diseases
- European Journal of Immunology
- Parasitoleg arbrofol
- FASEB Journal
- FEBS Journal
- Ffiniau mewn Imiwnoleg
- Haematologica
- Health Education Journal
- Imiwnoleg Dynol
- Imiwnoleg
- Imiwnoleg a Bioleg Cell
- Llythyrau Imiwnoleg
- Haint ac Imiwnedd
- Imiwnoleg Ryngwladol
- International Journal of Artificial Organs
- International Journal of Immunogenetics
- Wroleg Ryngwladol a Nefreineg
- JCI Insight
- Journal of the American Chemical Society
- Journal of the American Society of Nephrology
- Journal of Biological Chemistry
- Journal of Biological Regulators and Homeostatic Agents
- Journal of Clinical Investigation
- Journal of Experimental Medicine
- Journal of Immunology
- Journal of Infectious Diseases
- Journal of Leukocyte Biology
- Journal of Medicinal Chemistry
- Journal of Molecular Medicine
- Journal of Translational Medicine
- Arennau Rhyngwladol
- Malaria Journal
- Microbau a Haint
- Imiwnoleg Moleciwlaidd
- Imiwnoleg Mucosal
- Natur
- Cyfathrebu Natur
- Adolygiadau Natur Imiwnoleg
- Neffroleg, Dialysis, Trawsblannu
- OncoImmunology
- Adolygiadau Oncoleg
- Imiwnoleg parasitig
- Peritoneal Dialysis International
- PLoS UN
- Pathogenau PLoS
- Meddygaeth Drosiadol Gwyddoniaeth
- Adroddiadau Gwyddonol
- Tueddiadau mewn Imiwnoleg
- Tueddiadau mewn Meddygaeth Foleciwlaidd
- Tueddiadau mewn Parasitoleg
Meysydd goruchwyliaeth
Ardaloedd goruchwylio
- Haint ac imiwnedd
- Celloedd T anghonfensiynol
- Cynnwys ac ymgysylltu â'r cyhoedd
(interniaethau, prosiectau MSc / MPhil / MD / PhD)
Goruchwyliaeth gyfredol
Kirsty Emery
Daniel Griffiths
Kate Davies
Siva Oruganti
Prosiectau'r gorffennol
Myfyrwyr PhD
Linda Moet (PhD 2023):
"Elucidating llwybr metabolite imiwnedd mewn sepsis"
(Cyd-oruchwyliwr; Prif oruchwyliwr Peter Ghazal, gyda Valerie O'Donnell)
Ross Burton (PhD 2023):
"Nodi biofarcwyr imiwnolegol sepsis gan ddefnyddio biowybodeg cytometreg a dysgu peirianyddol"
(Prif oruchwyliwr; gydag Andreas Artemiou, Peter Ghazal, Matt Morgan)
Teja Rus (PhD 2021):
"Cynhyrchu offer arbrofol ar gyfer astudio prosesu antigen tiwmor gan γδ T-APCs dynol: Prosesu antigenau tiwmor a sefydlu imiwnedd gwrth-tiwmor"
(Prif oruchwyliwr; Bernhard Moser)
Ariadni Kouzeli (PhD 2020):
"CXCL14 swyddogaeth a chelloedd targed mewn meinweoedd iach"
(Prif oruchwyliwr; Bernhard Moser)
Amy Brook (PhD 2019):
"MicroRNAs lleol mewn cleifion dialysis peritoneal sydd â peritonitis acíwt"
(Prif oruchwyliwr; gyda Donald Fraser, Tim Bowen)
Chris Tyler (PhD 2016):
"Rheoli ymatebion celloedd CD4 + T gan T-APCs"
(Prif oruchwyliwr; gyda Bernhard Moser)
Anna Rita Liuzzi (PhD 2015):
"Ymatebion llidiol anghonfensiynol sy'n cael eu gyrru gan gell T yn ystod peritonitis acíwt: goblygiadau ar gyfer diagnosis a therapi cleifion dialysis peritoneal"
(Prif oruchwyliwr; gyda Tim Bowen)
Hung-Chang Chen (PhD 2015):
"Imiwnotherapi celloedd γδ T Dynol ar gyfer canser y fron"
(Prif oruchwyliwr; gyda Richard Clarkson)
Matt Morgan (PhD 2014):
"Olion bysedd imiwnedd mewn sepsis difrifol acíwt"
(Cyd-oruchwyliwr; Prif oruchwyliwr Judith Hall)
Luke Piggott (PhD 2012):
"Ymchwilio i botensial therapiwtig protein ataliol tebyg i FLICE cellog a TRAIL mewn modelau cyn-glinigol o ganser y fron"
(Prif oruchwyliwr; Richard Clarkson)
Chan-Yu Lin (PhD 2012):
"Rôl celloedd γδ T mewn haint bacteriol sy'n gysylltiedig â dialysis peritoneal"
(Prif oruchwyliwr; gyda Nick Topley)
Martin Davey (PhD 2012):
"Croessgwrs Cellog o gelloedd Vγ9/Vδ2 T dynol, niwtroffiliaid a monocytau mewn ymateb i heintiau bacteriol"
(Prif oruchwyliwr; gyda Bernhard Moser)
Raj Bansal (PhD 2012):
"B cell cymorth a ddarperir gan gelloedd γδ T dynol"
(Prif oruchwyliwr; gyda Bernhard Moser)
Myfyrwyr MD
Nicola Reeves (MD 2021):
"Effaith safoni newidynnau mewn-weithredol ar fynychder heintiadau safle llawfeddygol mewn llawfeddygaeth colorectal yng Nghymru"
(Cyd-oruchwyliwr; Prif oruchwyliwr Jared Torkington, gydag Ian Weeks)
Myfyrwyr MPhil
Emily Jacob (MPhil 2022):
"Olion bysedd imiwnedd o heintiau bacteriol mewn sirosis digolledu"
(Cyd-oruchwyliwr; y prif oruchwyliwr Thomas Pembroke)
Myfyrwyr MSc
Al-Motaz Rizek (MSc 2024):
"Modiwleiddio imiwnedd humoral cyfryngu celloedd-T yn ystod haint bacteriol difrifol"
(Cyd-oruchwyliwr; y prif oruchwyliwr James McLaren, gyda Kate Davies)
Ogbukagu Chioma (MSc 2024):
"Pennu agweddau academaidd at ymgysylltu â'r cyhoedd mewn ymwrthedd gwrthficrobaidd"
(Cyd-oruchwyliwr; Prif Oruchwyliwr Jon Tyrrell)
Sona Galla (MSc 2024)
"Sgrinio amgylcheddol ar gyfer ymwrthedd gwrthficrobaidd (AMR) sy'n cael ei bweru gan ymgysylltu â'r cyhoedd yn effeithiol"
(Cyd-oruchwyliwr; Prif Oruchwyliwr Jon Tyrrell)
Oluwatimilehin Okundalaye (MSc 2024):
Gwella dealltwriaeth ac atal ymwrthedd gwrthficrobaidd (AMR) mewn ysgolion drwy ddysgu gamgyfunol
(Cyd-oruchwyliwr; Prif Oruchwyliwr Jon Tyrrell)
Amalraj Eyyath Veettil (MSc 2024):
"Datblygu a gwerthuso deunydd addysg ddigidol i wella ymwybyddiaeth y cyhoedd o reoli heintiau"
(Cyd-oruchwyliwr; Prif Oruchwyliwr Jon Tyrrell)
Josephine Banda (MSc 2023):
"Archwilio'r dirwedd immunomodulatory mewn haint P. falciparum asymptomatig"
(Prif oruchwyliwr; Ian Humphreys)
Lucy Sheikh (MSc 2023):
"Celloedd T gwrthficrobaidd camweithredol immunophenoteipio yn ystod sepsis"
(Prif oruchwyliwr; James McLaren)
Haritha Ayanikkad (MSc 2023):
"Astudiaeth ar ymgysylltu â'r cyhoedd i wella nwyddau ar hylendid bwyd a llythrennedd microbaidd mewn plant ysgol"
(Cyd-oruchwyliwr; Prif Oruchwyliwr Jon Tyrrell)
Vasudev Gopakumar (MSc 2023):
"Ymgysylltu â'r cyhoedd mewn hylendid a microbioleg ymhlith plant ifanc drwy ymyriadau llwyddiannus"
(Cyd-oruchwyliwr; Prif Oruchwyliwr Jon Tyrrell)
Chiamaka Nnamdi (MSc 2023):
Creu ymwybyddiaeth o ymwrthedd gwrthficrobaidd i blant 7 i 14 oed gan ddefnyddio Staphylococcus aureus fel astudiaeth achos"
(Cyd-oruchwyliwr; Prif Oruchwyliwr Jon Tyrrell)
Rachel Oyebode (MSc 2023):
"Creu ymwybyddiaeth o ymwrthedd gwrthficrobaidd mewn plant sy'n defnyddio Staphylococcus aureus fel astudiaeth achos"
(Cyd-oruchwyliwr; Prif Oruchwyliwr Jon Tyrrell)
Katherine Stanswood (MSc 2022):
"Mecanweithiau imiwnoteipio camweithrediad celloedd T yn ystod dyfodiad sepsis"
(Prif oruchwyliwr; James McLaren)
Ymgysylltu
I am passionate about engaging and involving the public in my research and disseminate relevant findings to specialist and lay audiences.
As Engagement Lead of the Systems Immunity Research Institute, I conceive, oversee and coordinate a wide range of engagement and involvement activities, and aim to reach out to all stake-holders in our research - patients, health care providers, schools, policy makers, media, funders, industry and the general public.
I established and chair a Lay Faculty for the Systems Immunity Research Institute consisting of members of the public who provide valuable feedback on research proposals, study protocols, consent forms, news items and press releases, and help foster a close dialogue between local scientists and the wider public. This Lay Faculty has developed into a flagship involvement activity at Cardiff University and has received very positive feedback from Health and Care Research Wales and the Wellcome Trust.
In addition to facilitating and promoting engagement activities by colleagues across the Systems Immunity Research Institute and the College of Biomedical and Life Sciences, over the past 3 years I directly developed and contributed to activities such as 1) showcasing Cardiff research twice at Techniquest, the local Science museum; 2) promoting the importance of international research and collaboration for Cardiff University, Wales and the UK at receptions in the National Assembly for Wales and the House of Commons; 3) hosting the MP for Cardiff Central, Jo Stevens, at the Annual Infection & Immunity Meeting 2017; 4) creating educational computer games for primary schools; 5) developing a Welsh-medium philosophy/immunology workshop for primary school children; 6) establishing contacts with Radio Glamorgan, the local hospital radio station; 7) designing a Cardiff-wide bus stop poster campaign; 8) running a university-wide picture/artwork competition; 9) celebrating diversity and equality across Infection & Immunity, the School of Medicine and the University as a whole, and promoting the importance of international collaboration and training for local research and innovation; and 10) collaborating with BBC Wales on a programme about sepsis involving BBC weatherman Derek Brockway, and on sourcing laboratory equipment and props for the Dr Who Christmas Special 2014.
As Web Editor of the Systems Immunity URI (and its predecessors, the i3-IRG and the Institute of Infection & Immunity, since 2009), I have substantially improved the visibility of local research, teaching, innovation and engagement, accompanied by successful social media accounts (>1,600 Twitter followers). I also created an interactive ‘γδ T cell Forum’, which has >1,000 followers from >50 countries and has developed into a key networking resource in the field.
Through my participation in the core activities of the British Society for Immunology (BSI), the largest immunological society in Europe, I directly promote immunology-related research, public engagement and education in Wales, the UK and beyond. I was elected as BSI Trustee in 2017, after serving two terms as Regional Representative for Wales on the BSI Forum (2010-2016), the Society’s ‘think tank’. As one of only 12 Trustees, I am directly responsible for the effective operation of the Society, with regard to finance, governance, strategy and supervision of its CEO. As Chairman of the BSI South Wales regional group (2007-2015), I established Cardiff as one of the most active and visible regional groups in the UK, increased its annual budget eight-fold, and created the prestigious annual Jonathan Boulter Memorial Lecture given by the leading immunologists in the world.
Contact Details
+44 29206 87011
Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Ystafell 3F08, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Themâu ymchwil
Arbenigeddau
- Imiwnoleg
- Afiechydon heintus
- Cynnwys ac ymgysylltu â'r cyhoedd
- Imiwnedd celloedd T
- Biofarcwyr
