![Matthias Eberl](https://profiles-cardiff.imgix.net/attachments/4232?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Professor Matthias Eberl
Professor of Translational Immunology, Division of Infection and Immunity. Joint Academic Lead for Public Involvement and Engagement, School of Medicine.
- Available for postgraduate supervision
Overview
I have always been interested in the molecular and cellular basis of host-pathogen relationships and the underlying modulation of complex immune responses.
During my PhD in Giessen I established a screening method to identify CD4+ T cell antigens from cDNA libraries of the parasite Schistosoma mansoni. I then extended these studies during a two-year postdoc in York (UK), and investigated the cellular and humoral immune response to schistosomes upon infection and vaccination.
My research since 2000 in Giessen, Bern and Cardiff has concentrated on defining the role of human γδ T cells in bridging innate and adaptive immune responses.
γδ T cells are the prototype of 'unconventional' lymphocytes in that they are not restricted by classical MHC and combine characteristics of 'conventional' T cells, NK cells and myeloid cells. Normally only constituting a minor population in human blood, they occupy a unique niche in microbial recognition and contribute to stress surveillance and barrier protection.
More recently we started to characterise early immune responses in acutely infected patients, and define pathogen-specific signatures of cellular and soluble biomarkers ('immune fingerprints'), using flow cytometry, multiplex ELISA techniques and mathematical approaches.
Our work is placed at the interface of basic, translational, computational and clinical research, and benefits greatly from interdisciplinary collaborations with immunologists, microbiologists, biochemists, epidemiologists, data scientists, clinicians and commercial partners.
Besides implications for diagnosis and treatment of microbial infections our work has consequences for vaccine design and immunotherapy.
Publication
2024
- Giannoni, E. et al. 2024. Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner. European Journal of Immunology 54(10), article number: 2451190. (10.1002/eji.202451190)
- Burton, R. J. et al. 2024. Conventional and unconventional T cell responses contribute to the prediction of clinical outcome and causative bacterial pathogen in sepsis patients. Clinical & Experimental Immunology 216(3), pp. 293-306. (10.1093/cei/uxae019)
- Damani-Yokota, P. and Eberl, M. 2024. The γδ T Cell Club: bringing a global scientific community together in the age of Zoom. Immunology & Cell Biology 102(5), pp. 302-307. (10.1111/imcb.12742)
- Tyrrell, J. M., Ayanikkad, H. U., Nalleppilil-Gopakumar, V., Oyebode, R., Nmamdi Blessing, C., Hatch, S. and Eberl, M. 2024. Combining postgraduate research training, public engagement and primary school science education - A Superbugs Master (MSc) class. Frontiers in Microbiology (10.3389/fmicb.2024.1380045)
- Nollett, C., Eberl, M., Fitzgibbon, J., Joseph-Williams, N. and Hatch, S. 2024. Public involvement and engagement in scientific research and higher education: The only way is ethics?. Research Involvement and Engagement 10(1), article number: 50. (10.1186/s40900-024-00587-x)
- Leon-Lara, X. et al. 2024. γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis. Journal of Experimental Medicine 221(7), article number: e20231987. (10.1084/jem.20231987)
- Eberl, M. and Cruickshank, S. M. 2024. A culture shift to support public involvement and engagement in research. Journal of Experimental Medicine 221(6), article number: e20240268. (10.1084/jem.20240268)
- Tyler, C. J. et al. 2024. IL-21 conditions antigen-presenting human γδ T-cells to promote IL-10 expression in naïve and memory CD4+ T-cells. Discovery Immunology (10.1093/discim/kyae008)
- Tyrrell, J. et al. 2024. Superbugs online: co-production of an educational website to increase public understanding of the microbial world in, on and around us. Frontiers in Microbiology 15, article number: 1340350. (10.3389/fmicb.2024.1340350)
2023
- Silva-Santos, B., Ribot, J. C., Adams, E. J., Willcox, B. E. and Eberl, M. 2023. γδ T cell explorations seek terra firma. Nature Immunology 24, pp. 1606-1609. (10.1038/s41590-023-01606-x)
- Eberl, M., Joseph-Williams, N., Nollett, C., Fitzgibbon, J. and Hatch, S. 2023. Overcoming the disconnect between scientific research and the public. Immunology and Cell Biology 101(7), pp. 590-597. (10.1111/imcb.12657)
- Cuff, S. et al. 2023. Inflammatory biomarker signatures in post-surgical drain fluid may detect anastomotic leaks within 48 hours of colorectal resection. Techniques in Coloproctology (10.1007/s10151-023-02841-y)
- Burton, R. J., Cuff, S. M., Morgan, M. P., Artemiou, A. and Eberl, M. 2023. GeoWaVe: Geometric median clustering with weighted voting for ensemble clustering of cytometry data. Bioinformatics 39(1), article number: btac751. (10.1093/bioinformatics/btac751)
2022
- Cuff, S. M., Merola, J. P., Eberl, M. and Gray, W. P. 2022. Presence of ventriculoperitoneal and lumbar shunts stimulate long lasting non-inflammatory changes in the cerebrospinal fluid distinct from the response to bacterial infection. [Online]. medRxiv. (10.1101/2022.10.12.22280998) Available at: https://doi.org/10.1101/2022.10.12.22280998
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Ponsford, M. J. et al. 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75(4), pp. 255-262. (10.1136/jclinpath-2020-207157)
- Tyrrell, J. M. et al. 2022. 'Superbugs': raising public awareness of antimicrobial resistance through a pop-up science shop. Research for All 6(1), pp. 1-21. (10.14324/RFA.06.1.06)
2021
- Kaminski, H., Couzi, L. and Eberl, M. 2021. Unconventional T cells and kidney disease. Nature Reviews Nephrology 17, pp. 795-813. (10.1038/s41581-021-00466-8)
- Eberl, M., Oldfield, E. and Herrmann, T. 2021. Editor's Note: Relates to: 'Immuno-antibiotics: targeting microbial metabolic pathways sensed by unconventional T cells'. Immunotherapy Advances 1(1), article number: ltab023. (10.1093/immadv/ltab023)
- Burton, R. J., Ahmed, R., Cuff, S. M., Baker, S., Artemiou, A. and Eberl, M. 2021. CytoPy: An autonomous cytometry analysis framework. PLoS Computational Biology 17(6), article number: e1009071. (10.1371/journal.pcbi.1009071)
- Eberl, M., Oldfield, E. and Herrmann, T. 2021. Immuno-antibiotics: Targeting microbial metabolic pathways sensed by unconventional T cells. Immunotherapy Advances 1(1), article number: ltab005. (10.1093/immadv/ltab005)
2020
- Cuff, S. M., Merola, J. P., Twohig, J. P., Eberl, M. and Gray, W. P. 2020. Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation. Brain Communications 2(2), article number: fcaa218. (10.1093/braincomms/fcaa218)
- Kouzeli, A. et al. 2020. CXCL14 preferentially synergizes with homeostatic chemokine receptor systems. Frontiers in Immunology 11, article number: 561404. (10.3389/fimmu.2020.561404)
- Goodlad, C. et al. 2020. Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis. Kidney International 97(6), pp. 1253-1259. (10.1016/j.kint.2020.01.044)
- Catar, R. A. et al. 2020. Control of neutrophil influx during peritonitis by transcriptional cross-regulation of chemokine CXCL1 by IL‐17 and IFN‐γ. Journal of Pathology 251(2), pp. 175-186. (10.1002/path.5438)
- Eberl, M. 2020. Antigen recognition by human γδ T cells: one step closer to knowing. Immunology and Cell Biology 98(5), pp. 351-354. (10.1111/imcb.12334)
- Raffray, L., Burton, R. J., Baker, S. E., Morgan, M. P. and Eberl, M. 2020. Zoledronate rescues immunosuppressed monocytes in sepsis patients. Immunology 159(1), pp. 88-95. (10.1111/imm.13132)
2019
- Gadalla, A. A. M. et al. 2019. Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms. Scientific Reports 9(1), article number: 19694. (10.1038/s41598-019-55523-x)
- Nguyen, C. T., Maverakis, E., Eberl, M. and Adamopoulos, I. E. 2019. γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity. Seminars in Immunopathology 41(5), pp. 595-605. (10.1007/s00281-019-00752-5)
- Burton, R. J., Albur, M., Eberl, M. and Cuff, S. M. 2019. Using artificial intelligence to reduce diagnostic workload without compromising detection of urinary tract infections. BMC Medical Informatics and Decision Making 19(1), article number: 171. (10.1186/s12911-019-0878-9)
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9, article number: 10136. (10.1038/s41598-019-46585-y)
- Pottanat, N. D. et al. 2019. Analysis of the Ribonuclease a superfamily of antimicrobial peptides in patients undergoing chronic peritoneal dialysis. Scientific Reports 9, pp. -., article number: 7753. (10.1038/s41598-019-44219-x)
2018
- Vermijlen, D., Gatti, D., Kouzeli, A., Rus, T. and Eberl, M. 2018. γδ T cell responses: How many ligands will it take till we know?. Seminars in Cell and Developmental Biology 84, pp. 75-86. (10.1016/j.semcdb.2017.10.009)
- Chakera, A., Mulroney, K., Shak, H., McGuire, A., Eberl, M. and Topley, N. 2018. Peritonitis in Peritoneal Dialysis patients: the case for rapid diagnosis, targeted treatment and monitoring to improve outcomes. European Medical Journal Nephrology 6, pp. 56-64.
- McCarthy, N. E. and Eberl, M. 2018. Human γδ T-cell control of mucosal immunity and inflammation. Frontiers in Immunology 9, article number: 985. (10.3389/fimmu.2018.00985)
- Rhodes, D. A. et al. 2018. Regulation of human γδ T cells by BTN3A1 protein stability and ATP-binding cassette transporters. Frontiers in Immunology 9, article number: 662. (10.3389/fimmu.2018.00662)
2017
- Aufricht, C. et al. 2017. Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network. Kidney International 92(4), pp. 824-835. (10.1016/j.kint.2017.02.037)
- Chen, H. et al. 2017. Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells. Immunology and Cell Biology 95(7), pp. 620-629. (10.1038/icb.2017.21)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92(1), pp. 179-191. (10.1016/j.kint.2017.01.017)
- Howard, J. et al. 2017. The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection.. Journal of Infectious Diseases 215(10), pp. 1569-1579. (10.1093/infdis/jix149)
- Tyler, C. J., McCarthy, N. E., Lindsay, J. O., Stagg, A. J., Moser, B. and Eberl, M. 2017. Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin. The Journal of Immunology 198(9), article number: 1700003. (10.4049/jimmunol.1700003)
- Raby, A. et al. 2017. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology 28(2), pp. 461-478. (10.1681/ASN.2015080923)
2016
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990)
- Johansson, M. A. et al. 2016. Probiotic lactobacilli modulate staphylococcus aureus-induced activation of conventional and unconventional T cells and NK cells. Frontiers in Immunology 7, article number: 273. (10.3389/fimmu.2016.00273)
- Morgan, M., Szakmany, T., Power, S., Olaniyi, P., Kathy, R., Hall, J. E. and Eberl, M. 2016. Sepsis patients with first and second-hit infections show different outcomes depending on the causative organism. Frontiers in Microbiology 7, article number: 207. (10.3389/fmicb.2016.00207)
2015
- Liuzzi, A. R., McLaren, J. E., Price, D. and Eberl, M. 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36, pp. 31-37. (10.1016/j.coi.2015.06.002)
- Piggott, L., Omidvar, N., Martí Pérez, S., French, R., Eberl, M. and Clarkson, R. W. E. 2015. Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 17(1), pp. 96. (10.1186/s13058-015-0597-9)
- Bonneville, M. et al. 2015. Chicago 2014 – 30 years of γδ T cells. Cellular Immunology 296(1), pp. 3-9. (10.1016/j.cellimm.2014.11.001)
- Tyler, C. J., Doherty, D. G., Moser, B. and Eberl, M. 2015. Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system. Cellular Immunology 296(1), pp. 10-21. (10.1016/j.cellimm.2015.01.008)
- Rhodes, D. A. et al. 2015. Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. Journal of Immunology 194(5), pp. 2390-2398. (10.4049/jimmunol.1401064)
2014
- Eberl, M., Friberg, I. M., Liuzzi, A. R., Morgan, M. and Topley, N. 2014. Pathogen-specific immune fingerprints during acute infection: The diagnostic potential of human γδ T-cells. Frontiers in Immunology 5, article number: 572. (10.3389/fimmu.2014.00572)
- Khan, M. W. A., Eberl, M. and Moser, B. 2014. Potential use of γδ T cell-based vaccines in cancer immunotherapy. Frontiers in Immunology 5, article number: 512. (10.3389/fimmu.2014.00512)
- Davey, M. S. et al. 2014. Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells. Journal of Immunology 193(7), pp. 3704-3716. (10.4049/jimmunol.1401018)
- Khan, M. W. A. et al. 2014. Expanded human blood-derived gamma delta T cells display potent antigen-presentation functions. Frontiers in Immunology 5, article number: 344. (10.3389/fimmu.2014.00344)
2013
- Chen, H., Dieli, F. and Eberl, M. 2013. An unconventional TRAIL to cancer therapy. European Journal of Immunology 43(12), pp. 3159-3162. (10.1002/eji.201344105)
- Lin, C., Roberts, G. W., Kift-Morgan, A. P., Donovan, K., Topley, N. and Eberl, M. 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24(12), pp. 2002-2009. (10.1681/ASN.2013040332)
- Lin, C., Roberts, G. W., Kift-Morgan, A., Donovan, K. L., Topley, N. and Eberl, M. 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24(12), pp. 2002-2009. (10.1681/ASN.2013040332)
- Welton, J. L., Marti, S., Mahdi, M. H., Boobier, C., Barrett-Lee, P. and Eberl, M. 2013. γδ T cells predict outcome in zoledronate-treated breast cancer patients [Comment]. Oncologist 18(8), pp. E22-E23. (10.1634/theoncologist.2013-0097)
- Lin, C., Kift-Morgan, A. P., Moser, B., Topley, N. and Eberl, M. 2013. Suppression of pro-inflammatory T-cell responses by human mesothelial cells. Nephrology Dialysis Transplantation 28(7), pp. 1743-1750. (10.1093/ndt/gfs612)
- Welton, J. et al. 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28(3), pp. 464-471. (10.1002/jbmr.1797)
2012
- Silva-Santos, B., Schamel, W. W. A., Fisch, P. and Eberl, M. 2012. gamma delta T-cell conference 2012: Close encounters for the fifth time. European Journal of Immunology 42(12), pp. 3101-3105. (10.1002/eji.201270101)
- Riganti, C., Massaia, M., Davey, M. S. and Eberl, M. 2012. Human γδ T-cell responses in infection and immunotherapy: Common mechanisms, common mediators?. European Journal of Immunology 42(7), pp. 1668-1676. (10.1002/eji.201242492)
- Heuston, S., Begley, M., Davey, M., Eberl, M., Casey, P. G., Hill, C. and Gahan, C. G. M. 2012. HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe. Microbiology 158(7), pp. 1684-1693. (10.1099/mic.0.056069-0)
- Bansal, R. R., Mackay, C. R., Moser, B. and Eberl, M. 2012. IL-21 enhances the potential of human gamma delta T cells to provide B-cell help. European Journal of Immunology 42(1), pp. 110-119. (10.1002/eji.201142017)
2011
- Piggott, L., Omidvar, N., Marti-Perez, S., Eberl, M. and Clarkson, R. W. E. 2011. Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 13(5), article number: R88. (10.1186/bcr2945)
- Davey, M. S. et al. 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. Plos Pathogens 7(5), article number: e1002040. (10.1371/journal.ppat.1002040)
- Davey, M. S. et al. 2011. Failure to detect production of IL-10 by activated human neutrophils [Letter]. Nature Immunology 12(11), pp. 1017-1018. (10.1038/ni.2111)
- Moser, B. and Eberl, M. 2011. γδ T-APCs: a novel tool for immunotherapy? [Book Review]. Cellular and Molecular Life Sciences 68(14), pp. 2443-2452. (10.1007/s00018-011-0706-6)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
2010
- Meuter, S., Eberl, M. and Moser, B. 2010. Prolonged antigen survival and cytosolic export in cross-presenting human γδ T cells. Proceedings of the National Academy of Sciences of the United States of America 107(19), pp. 8730-8735. (10.1073/pnas.1002769107)
- Meraviglia, S. et al. 2010. In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Clinical and Experimental Immunology 161(2), pp. 290-297. (10.1111/j.1365-2249.2010.04167.x)
- Brown, A. C., Eberl, M., Crick, D. C., Jomaa, H. and Parish, T. 2010. The nonmevalonate pathway of isoprenoid biosynthesis in mycobacterium tuberculosis is essential and transcriptionally regulated by dxs. Journal of Bacteriology 192(9), pp. 2424-2433. (10.1128/JB.01402-09)
2009
- Eberl, M. and Moser, B. 2009. Monocytes and γδ T cells: close encounters in microbial infection. Trends in Immunology 30(12), pp. 562-568. (10.1016/j.it.2009.09.001)
- Eberl, M., Roberts, G. W., Meuter, S., Williams, J. D., Topley, N. and Moser, B. 2009. A rapid crosstalk of human gamma delta T cells and monocytes drives the acute inflammation in bacterial infections. Plos Pathogens 5(2), pp. 6-6., article number: e1000308. (10.1371/journal.ppat.1000308)
- Brandes, M. et al. 2009. Cross-presenting human gamma delta T cells induce robust CD8(+) alpha beta T cell responses. Proceedings of the National Academy of Sciences of the United States of America 106(7), pp. 2307-2312. (10.1073/pnas.0810059106)
2007
- Dieli, F. et al. 2007. Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Research 67(15), pp. 7450-7457. (10.1158/0008-5472.can-07-0199)
- Vermijlen, D. et al. 2007. Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. The Journal of Immunology 178(7), pp. 4304-4314. (10.4049/jimmunol.178.7.4304)
- Moser, B. and Eberl, M. 2007. gammadelta T cells: novel initiators of adaptive immunity [review]. Immunological Reviews 215(1), pp. 89-102. (10.1111/j.1600-065x.2006.00472.x)
- Zafranskaya, M., Oschamnn, P., Engel, R., Weishaupt, A., van Noort, J. M., Jomaa, H. and Eberl, M. 2007. Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis. Immunology 121(1), pp. 29-39. (10.1111/j.1365-2567.2006.02518.x)
2006
- Eberl, M., Wesch, D., Dieli, F. and Jomaa, H. 2006. Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells. Journal of Leukocyte Biology 79(4), pp. 663-6. (10.1189/jlb.1105640)
2005
- Eberl, M., Jomaa, H., Pircher, H. and Fisch, P. 2005. Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1). Journal of leukocyte biology 77, pp. 67-70. (10.1189/jlb.0204096)
2004
- Eberl, M., Beck, E., Christiansen, G. and Jamba, Z. 2004. Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so. Infection and Immunity 72(8), pp. 4881-3. (10.1128/IAI.72.8.4881-4883.2004)
- Eberl, M., Jomaa, H. and Hayday, A. C. 2004. Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells. Immunology 112(3), pp. 364-368. (10.1111/j.1365-2567.2004.01921.x)
- Begley, M., Gahan, C. G., Kollas, A. K., Hintz, M., Hill, C., Jomaa, H. and Eberl, M. 2004. The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. FEBS Letters 561(1-3), pp. 99-104. (10.1016/s0014-5793(04)00131-0)
2003
- Ostrovsky, D. N., Dyomina, G. R., Deryabina, Y. I., Goncharenko, A. ., Eberl, M., Shumaev, A. and Shashkov, S. 2003. Properties of 2-C-Methyl-D-Erythritol 2,4-Cyclopyrophosphate, an intermediate in Nonmevalonate Isoprenoid Biosynthesis. Applied Biochemistry and Microbiology c/c of Prikladnaia Biokhimiia i Mikrobiologiia 39(5), pp. 497-502. (10.1023/A:1025452804046)
- Eberl, M. and Jomaa, H. 2003. A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens [letter]. Trends in Immunology 24(8), pp. 407-409. (10.1016/s1471-4906(03)00170-4)
- Eberl, M., Hintz, M., Reichenberg, A., Kollas, A. K., Wiesner, J. and Jomaa, H. 2003. Microbial isoprenoid biosynthesis and human gammadelta T cell activation [review]. FEBS Letters 544(1-3), pp. 4-10. (10.1016/s0014-5793(03)00483-6)
- Reichenberg, A. et al. 2003. Replacing the pyrophosphate group of HMB-PP by diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism. Biorganic and Medicinal Chemistry Letters 13(7), pp. 1257-1260. (10.1016/s0960-894x(03)00138-0)
2002
- Kollas, A. K. et al. 2002. Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. FEBS Letters 532(3), pp. 432-436. (10.1016/s0014-5793(02)03725-0)
- Eberl, M., al-Sherbiny, M., Hagan, P., Ljubojevic, S., Thomas, A. W. and Wilson, R. A. 2002. A novel and sensitive method to monitor helminth infections by faecal sampling. Acta Tropica 83(2), pp. 183-187. (10.1016/s0001-706x(02)00089-x)
- Eberl, M., Engel, R., Beck, E. and Jomaa, H. 2002. Differentiation of human gamma-delta T cells towards distinct memory phenotypee. Cellular Immunology 218(1-2), pp. 1-6. (10.1016/s0008-8749(02)00519-1)
- Eberl, M. 2002. Don't count your interleukins before they've hatched [letter]. Trends in Immunology 23(7), pp. 341-342. (10.1016/s1471-4906(02)02239-1)
- Eberl, M. et al. 2002. Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology 106(2), pp. 200-211. (10.1046/j.1365-2567.2002.01414.x)
2001
- Hintz, M. et al. 2001. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Letters 509(2), pp. 317-322. (10.1016/s0014-5793(01)03191-x)
- Eberl, M. et al. 2001. Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees. Infection and Immunity 69(9), pp. 5352-5362. (10.1128/iai.69.9.5352-5362.2001)
- Altincicek, B. et al. 2001. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS Letters 499(1-2), pp. 37-40. (10.1016/s0014-5793(01)02516-9)
- Eberl, M. et al. 2001. Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?. Journal of Infectious Diseases 183(8), pp. 1238-1247. (10.1086/319691)
- Atincicek, B. et al. 2001. Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. The Journal of Immunology 166(6), pp. 3655-3658. (10.4049/jimmunol.166.6.3655)
- Kasper, G. et al. 2001. A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins. The Journal of Immunology 23(3), pp. 141-152. (10.1046/j.1365-3024.2001.00366.x)
2000
- Eberl, M., Beck, E., Coulson, P., Okamura, H., Wilson, R. A. and Mountford, A. P. 2000. IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigen. Vaccine 18(19), pp. 2002-2008. (10.1016/s0264-410x(99)00532-0)
1999
- Jomaa, H. et al. 1999. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285(5433), pp. 1573-1576. (10.1126/science.285.5433.1573)
- Eberl, M., Mountford, A. P., Jankovic, D. and Beck, E. 1999. Isolation of T-cell antigens by using a recombinant protein library and its application to the identification of novel vaccine candidates against schistosomiasis. Infection and Immunity 67(7), pp. 3383-3389.
Articles
- Giannoni, E. et al. 2024. Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner. European Journal of Immunology 54(10), article number: 2451190. (10.1002/eji.202451190)
- Burton, R. J. et al. 2024. Conventional and unconventional T cell responses contribute to the prediction of clinical outcome and causative bacterial pathogen in sepsis patients. Clinical & Experimental Immunology 216(3), pp. 293-306. (10.1093/cei/uxae019)
- Damani-Yokota, P. and Eberl, M. 2024. The γδ T Cell Club: bringing a global scientific community together in the age of Zoom. Immunology & Cell Biology 102(5), pp. 302-307. (10.1111/imcb.12742)
- Tyrrell, J. M., Ayanikkad, H. U., Nalleppilil-Gopakumar, V., Oyebode, R., Nmamdi Blessing, C., Hatch, S. and Eberl, M. 2024. Combining postgraduate research training, public engagement and primary school science education - A Superbugs Master (MSc) class. Frontiers in Microbiology (10.3389/fmicb.2024.1380045)
- Nollett, C., Eberl, M., Fitzgibbon, J., Joseph-Williams, N. and Hatch, S. 2024. Public involvement and engagement in scientific research and higher education: The only way is ethics?. Research Involvement and Engagement 10(1), article number: 50. (10.1186/s40900-024-00587-x)
- Leon-Lara, X. et al. 2024. γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis. Journal of Experimental Medicine 221(7), article number: e20231987. (10.1084/jem.20231987)
- Eberl, M. and Cruickshank, S. M. 2024. A culture shift to support public involvement and engagement in research. Journal of Experimental Medicine 221(6), article number: e20240268. (10.1084/jem.20240268)
- Tyler, C. J. et al. 2024. IL-21 conditions antigen-presenting human γδ T-cells to promote IL-10 expression in naïve and memory CD4+ T-cells. Discovery Immunology (10.1093/discim/kyae008)
- Tyrrell, J. et al. 2024. Superbugs online: co-production of an educational website to increase public understanding of the microbial world in, on and around us. Frontiers in Microbiology 15, article number: 1340350. (10.3389/fmicb.2024.1340350)
- Silva-Santos, B., Ribot, J. C., Adams, E. J., Willcox, B. E. and Eberl, M. 2023. γδ T cell explorations seek terra firma. Nature Immunology 24, pp. 1606-1609. (10.1038/s41590-023-01606-x)
- Eberl, M., Joseph-Williams, N., Nollett, C., Fitzgibbon, J. and Hatch, S. 2023. Overcoming the disconnect between scientific research and the public. Immunology and Cell Biology 101(7), pp. 590-597. (10.1111/imcb.12657)
- Cuff, S. et al. 2023. Inflammatory biomarker signatures in post-surgical drain fluid may detect anastomotic leaks within 48 hours of colorectal resection. Techniques in Coloproctology (10.1007/s10151-023-02841-y)
- Burton, R. J., Cuff, S. M., Morgan, M. P., Artemiou, A. and Eberl, M. 2023. GeoWaVe: Geometric median clustering with weighted voting for ensemble clustering of cytometry data. Bioinformatics 39(1), article number: btac751. (10.1093/bioinformatics/btac751)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Ponsford, M. J. et al. 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75(4), pp. 255-262. (10.1136/jclinpath-2020-207157)
- Tyrrell, J. M. et al. 2022. 'Superbugs': raising public awareness of antimicrobial resistance through a pop-up science shop. Research for All 6(1), pp. 1-21. (10.14324/RFA.06.1.06)
- Kaminski, H., Couzi, L. and Eberl, M. 2021. Unconventional T cells and kidney disease. Nature Reviews Nephrology 17, pp. 795-813. (10.1038/s41581-021-00466-8)
- Eberl, M., Oldfield, E. and Herrmann, T. 2021. Editor's Note: Relates to: 'Immuno-antibiotics: targeting microbial metabolic pathways sensed by unconventional T cells'. Immunotherapy Advances 1(1), article number: ltab023. (10.1093/immadv/ltab023)
- Burton, R. J., Ahmed, R., Cuff, S. M., Baker, S., Artemiou, A. and Eberl, M. 2021. CytoPy: An autonomous cytometry analysis framework. PLoS Computational Biology 17(6), article number: e1009071. (10.1371/journal.pcbi.1009071)
- Eberl, M., Oldfield, E. and Herrmann, T. 2021. Immuno-antibiotics: Targeting microbial metabolic pathways sensed by unconventional T cells. Immunotherapy Advances 1(1), article number: ltab005. (10.1093/immadv/ltab005)
- Cuff, S. M., Merola, J. P., Twohig, J. P., Eberl, M. and Gray, W. P. 2020. Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation. Brain Communications 2(2), article number: fcaa218. (10.1093/braincomms/fcaa218)
- Kouzeli, A. et al. 2020. CXCL14 preferentially synergizes with homeostatic chemokine receptor systems. Frontiers in Immunology 11, article number: 561404. (10.3389/fimmu.2020.561404)
- Goodlad, C. et al. 2020. Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis. Kidney International 97(6), pp. 1253-1259. (10.1016/j.kint.2020.01.044)
- Catar, R. A. et al. 2020. Control of neutrophil influx during peritonitis by transcriptional cross-regulation of chemokine CXCL1 by IL‐17 and IFN‐γ. Journal of Pathology 251(2), pp. 175-186. (10.1002/path.5438)
- Eberl, M. 2020. Antigen recognition by human γδ T cells: one step closer to knowing. Immunology and Cell Biology 98(5), pp. 351-354. (10.1111/imcb.12334)
- Raffray, L., Burton, R. J., Baker, S. E., Morgan, M. P. and Eberl, M. 2020. Zoledronate rescues immunosuppressed monocytes in sepsis patients. Immunology 159(1), pp. 88-95. (10.1111/imm.13132)
- Gadalla, A. A. M. et al. 2019. Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms. Scientific Reports 9(1), article number: 19694. (10.1038/s41598-019-55523-x)
- Nguyen, C. T., Maverakis, E., Eberl, M. and Adamopoulos, I. E. 2019. γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity. Seminars in Immunopathology 41(5), pp. 595-605. (10.1007/s00281-019-00752-5)
- Burton, R. J., Albur, M., Eberl, M. and Cuff, S. M. 2019. Using artificial intelligence to reduce diagnostic workload without compromising detection of urinary tract infections. BMC Medical Informatics and Decision Making 19(1), article number: 171. (10.1186/s12911-019-0878-9)
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9, article number: 10136. (10.1038/s41598-019-46585-y)
- Pottanat, N. D. et al. 2019. Analysis of the Ribonuclease a superfamily of antimicrobial peptides in patients undergoing chronic peritoneal dialysis. Scientific Reports 9, pp. -., article number: 7753. (10.1038/s41598-019-44219-x)
- Vermijlen, D., Gatti, D., Kouzeli, A., Rus, T. and Eberl, M. 2018. γδ T cell responses: How many ligands will it take till we know?. Seminars in Cell and Developmental Biology 84, pp. 75-86. (10.1016/j.semcdb.2017.10.009)
- Chakera, A., Mulroney, K., Shak, H., McGuire, A., Eberl, M. and Topley, N. 2018. Peritonitis in Peritoneal Dialysis patients: the case for rapid diagnosis, targeted treatment and monitoring to improve outcomes. European Medical Journal Nephrology 6, pp. 56-64.
- McCarthy, N. E. and Eberl, M. 2018. Human γδ T-cell control of mucosal immunity and inflammation. Frontiers in Immunology 9, article number: 985. (10.3389/fimmu.2018.00985)
- Rhodes, D. A. et al. 2018. Regulation of human γδ T cells by BTN3A1 protein stability and ATP-binding cassette transporters. Frontiers in Immunology 9, article number: 662. (10.3389/fimmu.2018.00662)
- Aufricht, C. et al. 2017. Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network. Kidney International 92(4), pp. 824-835. (10.1016/j.kint.2017.02.037)
- Chen, H. et al. 2017. Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells. Immunology and Cell Biology 95(7), pp. 620-629. (10.1038/icb.2017.21)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92(1), pp. 179-191. (10.1016/j.kint.2017.01.017)
- Howard, J. et al. 2017. The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection.. Journal of Infectious Diseases 215(10), pp. 1569-1579. (10.1093/infdis/jix149)
- Tyler, C. J., McCarthy, N. E., Lindsay, J. O., Stagg, A. J., Moser, B. and Eberl, M. 2017. Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin. The Journal of Immunology 198(9), article number: 1700003. (10.4049/jimmunol.1700003)
- Raby, A. et al. 2017. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology 28(2), pp. 461-478. (10.1681/ASN.2015080923)
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990)
- Johansson, M. A. et al. 2016. Probiotic lactobacilli modulate staphylococcus aureus-induced activation of conventional and unconventional T cells and NK cells. Frontiers in Immunology 7, article number: 273. (10.3389/fimmu.2016.00273)
- Morgan, M., Szakmany, T., Power, S., Olaniyi, P., Kathy, R., Hall, J. E. and Eberl, M. 2016. Sepsis patients with first and second-hit infections show different outcomes depending on the causative organism. Frontiers in Microbiology 7, article number: 207. (10.3389/fmicb.2016.00207)
- Liuzzi, A. R., McLaren, J. E., Price, D. and Eberl, M. 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36, pp. 31-37. (10.1016/j.coi.2015.06.002)
- Piggott, L., Omidvar, N., Martí Pérez, S., French, R., Eberl, M. and Clarkson, R. W. E. 2015. Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 17(1), pp. 96. (10.1186/s13058-015-0597-9)
- Bonneville, M. et al. 2015. Chicago 2014 – 30 years of γδ T cells. Cellular Immunology 296(1), pp. 3-9. (10.1016/j.cellimm.2014.11.001)
- Tyler, C. J., Doherty, D. G., Moser, B. and Eberl, M. 2015. Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system. Cellular Immunology 296(1), pp. 10-21. (10.1016/j.cellimm.2015.01.008)
- Rhodes, D. A. et al. 2015. Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. Journal of Immunology 194(5), pp. 2390-2398. (10.4049/jimmunol.1401064)
- Eberl, M., Friberg, I. M., Liuzzi, A. R., Morgan, M. and Topley, N. 2014. Pathogen-specific immune fingerprints during acute infection: The diagnostic potential of human γδ T-cells. Frontiers in Immunology 5, article number: 572. (10.3389/fimmu.2014.00572)
- Khan, M. W. A., Eberl, M. and Moser, B. 2014. Potential use of γδ T cell-based vaccines in cancer immunotherapy. Frontiers in Immunology 5, article number: 512. (10.3389/fimmu.2014.00512)
- Davey, M. S. et al. 2014. Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells. Journal of Immunology 193(7), pp. 3704-3716. (10.4049/jimmunol.1401018)
- Khan, M. W. A. et al. 2014. Expanded human blood-derived gamma delta T cells display potent antigen-presentation functions. Frontiers in Immunology 5, article number: 344. (10.3389/fimmu.2014.00344)
- Chen, H., Dieli, F. and Eberl, M. 2013. An unconventional TRAIL to cancer therapy. European Journal of Immunology 43(12), pp. 3159-3162. (10.1002/eji.201344105)
- Lin, C., Roberts, G. W., Kift-Morgan, A. P., Donovan, K., Topley, N. and Eberl, M. 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24(12), pp. 2002-2009. (10.1681/ASN.2013040332)
- Lin, C., Roberts, G. W., Kift-Morgan, A., Donovan, K. L., Topley, N. and Eberl, M. 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24(12), pp. 2002-2009. (10.1681/ASN.2013040332)
- Welton, J. L., Marti, S., Mahdi, M. H., Boobier, C., Barrett-Lee, P. and Eberl, M. 2013. γδ T cells predict outcome in zoledronate-treated breast cancer patients [Comment]. Oncologist 18(8), pp. E22-E23. (10.1634/theoncologist.2013-0097)
- Lin, C., Kift-Morgan, A. P., Moser, B., Topley, N. and Eberl, M. 2013. Suppression of pro-inflammatory T-cell responses by human mesothelial cells. Nephrology Dialysis Transplantation 28(7), pp. 1743-1750. (10.1093/ndt/gfs612)
- Welton, J. et al. 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28(3), pp. 464-471. (10.1002/jbmr.1797)
- Silva-Santos, B., Schamel, W. W. A., Fisch, P. and Eberl, M. 2012. gamma delta T-cell conference 2012: Close encounters for the fifth time. European Journal of Immunology 42(12), pp. 3101-3105. (10.1002/eji.201270101)
- Riganti, C., Massaia, M., Davey, M. S. and Eberl, M. 2012. Human γδ T-cell responses in infection and immunotherapy: Common mechanisms, common mediators?. European Journal of Immunology 42(7), pp. 1668-1676. (10.1002/eji.201242492)
- Heuston, S., Begley, M., Davey, M., Eberl, M., Casey, P. G., Hill, C. and Gahan, C. G. M. 2012. HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe. Microbiology 158(7), pp. 1684-1693. (10.1099/mic.0.056069-0)
- Bansal, R. R., Mackay, C. R., Moser, B. and Eberl, M. 2012. IL-21 enhances the potential of human gamma delta T cells to provide B-cell help. European Journal of Immunology 42(1), pp. 110-119. (10.1002/eji.201142017)
- Piggott, L., Omidvar, N., Marti-Perez, S., Eberl, M. and Clarkson, R. W. E. 2011. Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 13(5), article number: R88. (10.1186/bcr2945)
- Davey, M. S. et al. 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. Plos Pathogens 7(5), article number: e1002040. (10.1371/journal.ppat.1002040)
- Davey, M. S. et al. 2011. Failure to detect production of IL-10 by activated human neutrophils [Letter]. Nature Immunology 12(11), pp. 1017-1018. (10.1038/ni.2111)
- Moser, B. and Eberl, M. 2011. γδ T-APCs: a novel tool for immunotherapy? [Book Review]. Cellular and Molecular Life Sciences 68(14), pp. 2443-2452. (10.1007/s00018-011-0706-6)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
- Meuter, S., Eberl, M. and Moser, B. 2010. Prolonged antigen survival and cytosolic export in cross-presenting human γδ T cells. Proceedings of the National Academy of Sciences of the United States of America 107(19), pp. 8730-8735. (10.1073/pnas.1002769107)
- Meraviglia, S. et al. 2010. In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Clinical and Experimental Immunology 161(2), pp. 290-297. (10.1111/j.1365-2249.2010.04167.x)
- Brown, A. C., Eberl, M., Crick, D. C., Jomaa, H. and Parish, T. 2010. The nonmevalonate pathway of isoprenoid biosynthesis in mycobacterium tuberculosis is essential and transcriptionally regulated by dxs. Journal of Bacteriology 192(9), pp. 2424-2433. (10.1128/JB.01402-09)
- Eberl, M. and Moser, B. 2009. Monocytes and γδ T cells: close encounters in microbial infection. Trends in Immunology 30(12), pp. 562-568. (10.1016/j.it.2009.09.001)
- Eberl, M., Roberts, G. W., Meuter, S., Williams, J. D., Topley, N. and Moser, B. 2009. A rapid crosstalk of human gamma delta T cells and monocytes drives the acute inflammation in bacterial infections. Plos Pathogens 5(2), pp. 6-6., article number: e1000308. (10.1371/journal.ppat.1000308)
- Brandes, M. et al. 2009. Cross-presenting human gamma delta T cells induce robust CD8(+) alpha beta T cell responses. Proceedings of the National Academy of Sciences of the United States of America 106(7), pp. 2307-2312. (10.1073/pnas.0810059106)
- Dieli, F. et al. 2007. Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Research 67(15), pp. 7450-7457. (10.1158/0008-5472.can-07-0199)
- Vermijlen, D. et al. 2007. Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. The Journal of Immunology 178(7), pp. 4304-4314. (10.4049/jimmunol.178.7.4304)
- Moser, B. and Eberl, M. 2007. gammadelta T cells: novel initiators of adaptive immunity [review]. Immunological Reviews 215(1), pp. 89-102. (10.1111/j.1600-065x.2006.00472.x)
- Zafranskaya, M., Oschamnn, P., Engel, R., Weishaupt, A., van Noort, J. M., Jomaa, H. and Eberl, M. 2007. Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis. Immunology 121(1), pp. 29-39. (10.1111/j.1365-2567.2006.02518.x)
- Eberl, M., Wesch, D., Dieli, F. and Jomaa, H. 2006. Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells. Journal of Leukocyte Biology 79(4), pp. 663-6. (10.1189/jlb.1105640)
- Eberl, M., Jomaa, H., Pircher, H. and Fisch, P. 2005. Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1). Journal of leukocyte biology 77, pp. 67-70. (10.1189/jlb.0204096)
- Eberl, M., Beck, E., Christiansen, G. and Jamba, Z. 2004. Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so. Infection and Immunity 72(8), pp. 4881-3. (10.1128/IAI.72.8.4881-4883.2004)
- Eberl, M., Jomaa, H. and Hayday, A. C. 2004. Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells. Immunology 112(3), pp. 364-368. (10.1111/j.1365-2567.2004.01921.x)
- Begley, M., Gahan, C. G., Kollas, A. K., Hintz, M., Hill, C., Jomaa, H. and Eberl, M. 2004. The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. FEBS Letters 561(1-3), pp. 99-104. (10.1016/s0014-5793(04)00131-0)
- Ostrovsky, D. N., Dyomina, G. R., Deryabina, Y. I., Goncharenko, A. ., Eberl, M., Shumaev, A. and Shashkov, S. 2003. Properties of 2-C-Methyl-D-Erythritol 2,4-Cyclopyrophosphate, an intermediate in Nonmevalonate Isoprenoid Biosynthesis. Applied Biochemistry and Microbiology c/c of Prikladnaia Biokhimiia i Mikrobiologiia 39(5), pp. 497-502. (10.1023/A:1025452804046)
- Eberl, M. and Jomaa, H. 2003. A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens [letter]. Trends in Immunology 24(8), pp. 407-409. (10.1016/s1471-4906(03)00170-4)
- Eberl, M., Hintz, M., Reichenberg, A., Kollas, A. K., Wiesner, J. and Jomaa, H. 2003. Microbial isoprenoid biosynthesis and human gammadelta T cell activation [review]. FEBS Letters 544(1-3), pp. 4-10. (10.1016/s0014-5793(03)00483-6)
- Reichenberg, A. et al. 2003. Replacing the pyrophosphate group of HMB-PP by diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism. Biorganic and Medicinal Chemistry Letters 13(7), pp. 1257-1260. (10.1016/s0960-894x(03)00138-0)
- Kollas, A. K. et al. 2002. Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. FEBS Letters 532(3), pp. 432-436. (10.1016/s0014-5793(02)03725-0)
- Eberl, M., al-Sherbiny, M., Hagan, P., Ljubojevic, S., Thomas, A. W. and Wilson, R. A. 2002. A novel and sensitive method to monitor helminth infections by faecal sampling. Acta Tropica 83(2), pp. 183-187. (10.1016/s0001-706x(02)00089-x)
- Eberl, M., Engel, R., Beck, E. and Jomaa, H. 2002. Differentiation of human gamma-delta T cells towards distinct memory phenotypee. Cellular Immunology 218(1-2), pp. 1-6. (10.1016/s0008-8749(02)00519-1)
- Eberl, M. 2002. Don't count your interleukins before they've hatched [letter]. Trends in Immunology 23(7), pp. 341-342. (10.1016/s1471-4906(02)02239-1)
- Eberl, M. et al. 2002. Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology 106(2), pp. 200-211. (10.1046/j.1365-2567.2002.01414.x)
- Hintz, M. et al. 2001. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Letters 509(2), pp. 317-322. (10.1016/s0014-5793(01)03191-x)
- Eberl, M. et al. 2001. Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees. Infection and Immunity 69(9), pp. 5352-5362. (10.1128/iai.69.9.5352-5362.2001)
- Altincicek, B. et al. 2001. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS Letters 499(1-2), pp. 37-40. (10.1016/s0014-5793(01)02516-9)
- Eberl, M. et al. 2001. Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?. Journal of Infectious Diseases 183(8), pp. 1238-1247. (10.1086/319691)
- Atincicek, B. et al. 2001. Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. The Journal of Immunology 166(6), pp. 3655-3658. (10.4049/jimmunol.166.6.3655)
- Kasper, G. et al. 2001. A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins. The Journal of Immunology 23(3), pp. 141-152. (10.1046/j.1365-3024.2001.00366.x)
- Eberl, M., Beck, E., Coulson, P., Okamura, H., Wilson, R. A. and Mountford, A. P. 2000. IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigen. Vaccine 18(19), pp. 2002-2008. (10.1016/s0264-410x(99)00532-0)
- Jomaa, H. et al. 1999. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285(5433), pp. 1573-1576. (10.1126/science.285.5433.1573)
- Eberl, M., Mountford, A. P., Jankovic, D. and Beck, E. 1999. Isolation of T-cell antigens by using a recombinant protein library and its application to the identification of novel vaccine candidates against schistosomiasis. Infection and Immunity 67(7), pp. 3383-3389.
Websites
- Cuff, S. M., Merola, J. P., Eberl, M. and Gray, W. P. 2022. Presence of ventriculoperitoneal and lumbar shunts stimulate long lasting non-inflammatory changes in the cerebrospinal fluid distinct from the response to bacterial infection. [Online]. medRxiv. (10.1101/2022.10.12.22280998) Available at: https://doi.org/10.1101/2022.10.12.22280998
- Burton, R. J. et al. 2024. Conventional and unconventional T cell responses contribute to the prediction of clinical outcome and causative bacterial pathogen in sepsis patients. Clinical & Experimental Immunology 216(3), pp. 293-306. (10.1093/cei/uxae019)
- Tyrrell, J. et al. 2024. Superbugs online: co-production of an educational website to increase public understanding of the microbial world in, on and around us. Frontiers in Microbiology 15, article number: 1340350. (10.3389/fmicb.2024.1340350)
- Eberl, M., Joseph-Williams, N., Nollett, C., Fitzgibbon, J. and Hatch, S. 2023. Overcoming the disconnect between scientific research and the public. Immunology and Cell Biology 101(7), pp. 590-597. (10.1111/imcb.12657)
- Tyrrell, J. M. et al. 2022. 'Superbugs': raising public awareness of antimicrobial resistance through a pop-up science shop. Research for All 6(1), pp. 1-21. (10.14324/RFA.06.1.06)
- Goodlad, C. et al. 2020. Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis. Kidney International 97(6), pp. 1253-1259. (10.1016/j.kint.2020.01.044)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92(1), pp. 179-191. (10.1016/j.kint.2017.01.017)
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990)
- Rhodes, D. A. et al. 2015. Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. Journal of Immunology 194(5), pp. 2390-2398. (10.4049/jimmunol.1401064)
- Davey, M. S. et al. 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. Plos Pathogens 7(5), article number: e1002040. (10.1371/journal.ppat.1002040)
- Eberl, M., Roberts, G. W., Meuter, S., Williams, J. D., Topley, N. and Moser, B. 2009. A rapid crosstalk of human gamma delta T cells and monocytes drives the acute inflammation in bacterial infections. Plos Pathogens 5(2), pp. 6-6., article number: e1000308. (10.1371/journal.ppat.1000308)
- Vermijlen, D. et al. 2007. Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. The Journal of Immunology 178(7), pp. 4304-4314. (10.4049/jimmunol.178.7.4304)
- Hintz, M. et al. 2001. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Letters 509(2), pp. 317-322. (10.1016/s0014-5793(01)03191-x)
Research
Immune fingerprints in acute infection
Diagnosing, treating and preventing infection in the face of a global spread of antimicrobial resistance and a constant risk of devastating pandemics is one of the greatest challenges of the 21st century. However, there remains a lack of appreciation of how the body senses and fights different types of pathogens.
Our research aims to explore and exploit the pathophysiological events underlying pathogen-specific inflammatory responses for diagnostic and therapeutic purposes. The immune system has evolved to survey the body constantly for potentially hazardous structures. Different pathogens express different molecular patterns and hence interact uniquely with distinct components of the immune system. The type of infection is therefore likely to evoke distinct immunological signatures, or ‘immune fingerprints’, that can be assessed quantitatively and qualitatively.
A prime example for this discrimination of different pathogens is the unique responsiveness of unconventional T cells to common microbial metabolites that are shared by many bacterial pathogens but are absent from human cells. γδ T cells and MAIT cells are rapidly drawn to sites of acute infection, where they will encounter invading microbes in the context of other immune cells, mainly neutrophils and monocytes, and the surrounding tissue.
Our findings indicate that in early infection this interplay will attract further effector cells, enhance the activity of scavenger cells and promote the development of microbe-specific immunity. However, if triggered at the wrong time or the wrong site, this reaction may lead to inflammation-related damage and affect patient outcomes. The centre stage unconventional T cells take in orchestrating inflammatory cascades in microbial infections identifies these cells as prime targets for novel treatments and diagnostics.
We are aiming to define local and systemic pathogen-specific signatures of soluble and cellular immune biomarkers in diseases where early and targeted intervention is key and where clinical outcomes will benefit from better and earlier diagnostics. For this, we are studying individuals presenting with acute conditions such as peritonitis, severe sepsis, urinary tract infection and ventriculitis, in collaborations with clinicians, microbiologists, statisticians, computer scientists and commercial partners.
Present and past group members
- Kirsty Emery, PhD Student 2023–
- Daniel Griffiths, PhD Student 2023–
- Kate Davies, PhD Student (co-supervisor) 2022–
- Siva Oruganti, PhD Student (co-supervisor) 2024–
- Aaron Bolitho, Senior Technician 2024–
- Jennifer Waterman, MD Student 2024–
- Nicholas Graves, SFP2 Trainee 2024-2025
- Raya Ahmed, Postdoc 2016-2019
- Sarah Baker, Research Assistant 2018-2021
- Josephine Banda, MSc Student (co-supervisor) 2023
- Raj Bansal, PhD Student 2007-2012
- Amy Brook, PhD Student 2015-2019
- Ross Burton, PhD Student 2018-2022
- Hung-Chang Chen, PhD Student 2011-2016
- Chantal Colmont, Research Assistant 2013-2014
- Friday Cox, Work Experience Student 2024
- Simone Cuff, Postdoc 2017-2022
- Martin Davey, PhD Student/Postdoc 2008-2013
- Kashia Dias, Work Experience Student 2024
- Ida Jackson (Friberg), Postdoc 2013-2015
- Emily Jacob, MPhil Student (co-supervisor) 2020-2022
- Maximilian Keisker, Erasmus Student 2017
- Ariadni Kouzeli, PhD Student (co-supervisor) 2015-2020
- Ann Kift-Morgan, Research Assistant 2011-2018
- Jack Leyshon, Senior Technician 2024
- Chan-Yu Lin, PhD Student 2009-2012
- Anna Rita Liuzzi, PhD student/Postdoc 2013-2016
- Christophe Macri, Internship Student 2009
- Salvador Martí Pérez, Postdoc 2009-2010
- Oliwia Michalak, PhD Student 2018-2020
- Linda Moet, PhD Student (co-supervisor) 2018-2022
- Matt Morgan, PhD Student (co-supervisor) 2011-2014
- Luke Piggott, PhD Student (co-supervisor) 2009-2012
- Loic Raffray, EU Marie Curie Fellow 2017-2018
- Nicola Reeves, MD Student (co-supervisor) 2019-2021
- Al-Motaz Rizek, MSc Student (co-supervisor) 2024
- Teja Rus, PhD Student (co-supervisor) 2015-2020
- Michele Scotto di Mase, Internship Student 2015
- Yasmin Shanneik, Erasmus Student 2014-2015
- Lucy Sheikh, MSc Student (co-supervisor) 2023
- Katie Stanswood, MSc Student (co-supervisor) 2022
- Chris Tyler, PhD Student 2012-2016
- Joanne Welton, Postdoc 2011-2013
- Jingjing Zhang, Postdoc 2015-2016
Grant support
2024-2026
Association of Surgeons of Great Britain, ASGBI and GUTS UK Surgical Research Award
"Early detection of anastomotic leak after colorectal surgery utilising peritoneal fluid soluble and non-soluble biomarkers"
Co-applicant (Principal applicant: Jennifer Waterman; co-applicants Prof. Jared Torkington, Dr. Nicola Reeves, Dr. Natalie Joseph-Williams)
£ 10,000 (24 months)
2023-2025
Health and Care Research Wales, Health Research Grant
"Early detection of anastomotic leak after colorectal surgery"
Principal Applicant (co-applicants: Prof. Jared Torkington, Dr. Nicola Reeves, Dr. Natalie Joseph-Williams, Dr. Rachel Morris, Dr. Susan Campbell)
£ 145,684 (24 months)
2023-2027
GW4 MRC DTP PhD Studentship (to Kirsty Emery)
"Control of mucosal immunity and intestinal integrity by human γδ T cells" (48 months)
Principal Applicant (co-applicants: Dr. Neil McCarthy, Dr. Gareth Jones)
ca. £ 100,000 (48 months)
2023-2026
Cardiff University Cancer Research Hub PhD Studentship (to Daniel Griffiths)
"Novel tools for analysis of high-dimensional cytometry data – implications for cancer immunology and immunotherapy"
Principal Applicant (co-applicants: Dr. Andreas Artemiou, Prof. Awen Gallimore)
£ 81,728 (36 months)
2022-2026
GW4 MRC DTP PhD Studentship (to Kate Davies)
"Suppression of T cell immunity and antibody production during virus infection and sepsis"
Co-applicant (Principal applicant: Dr. James McLaren; co-applicant: Dr. Gareth Jones)
ca. £ 100,000 (48 months)
2022
Welsh Government Sprint Programme
"Artificial intelligence-guided diagnosis and prognosis of post-operative sepsis"
Principal Applicant
£ 31,781
2021-2022
Health and Care Research Wales, Health Research Grant
"The epidemiology and impact of bacterial secondary infections and antimicrobial resistance on Intensive Care during the SARS-CoV-2 pandemic"
Co-applicant (Lead applicant: Dr. Lim Jones; with Dr. Mandy Wootton, Dr. James McLaren, Prof. Thomas Connor, Dr. Matt Morgan, Dr. Matt Wise, Dr. Harriet Hughes, Dr. Brendan Healey, Dr. Brad Spiller)
£ 74,000 (12 months)
2021
Wellcome Trust Institutional Translational Partnership Award (ITPA)
"Precision medicine-based diagnosis and prognosis of post-operative sepsis"
Principal Applicant (with Prof. Jared Torkington, Dr. Nicola Reeves, Dr. Matt Morgan, Dr. Andreas Artemiou, Dr. Simone Cuff, Ross Burton)
£19,969 (4 months)
2019-2021
ACCELERATE project
"Precision medicine-based diagnosis of post-surgical complications in patient undergoing abdominal surgery"
Principal Applicant (with Prof. Ian Weeks, Prof. Jared Torkington, Dr. Rachel Morris)
£ 468,913 (18 months)
2019-2020
Wellcome Trust ISSF3 Cross-Disciplinary Award
"Rapid detection of life-threatening neurological infection by detecting immune fingerprints in cerebrospinal fluid"
Principal Applicant (co-applicants: Prof. William Gray, Dr. Andreas Artemiou, Dr. Simone Cuff, Mr. Joseph Merola)
£ 49,996 (12 months)
2018-2021
Sêr Cymru II European Regional Development Fund Precision Medicine Fellowship (to Dr. Tom Pembroke)
"Immune fingerprinting of bacterial infections in cirrhosis"
Co-applicant (with Prof. Andrew Godkin)
£ 185,000 (36 months)
2018-2022
GW4 DTP PhD Studentship (to Oliwia Michalak)
"Machine-learning guided immune fingerprinting for rapid detection of life-threatening infection in liver cirrhosis
Principal Applicant (co-applicants: Dr. Tom Pembroke, Dr. Andreas Artemiou):
ca. £ 80,000 (42 months)
2018-2021
School of Medicine PhD Studentship (to Ross Burton)
"Systemic immune fingerprints in patients with acute severe sepsis"
Principal Applicant (co-applicants: Dr. Andreas Artemiou, Dr. Matt Morgan, Prof. Peter Ghazal):
ca. £ 60,000 (36 months)
2018
Wellcome Trust ISSF3 Cross-Disciplinary Award
"Immune fingerprints in haemodialysis patients with acute infection"
Principal Applicant (with Dr. Soma Meran, Dr. Matt Morgan, Dr. Simone Cuff, Dr. Andreas Artemiou, Prof. Donald Fraser)
£ 49,955 (12 months)
2017-2018
EU Horizon 2020, Marie Skłodowska-Curie Individual Fellowship (to Dr. Loic Raffray)
"Innate-like T-cells in sepsis (ILTIS): Implications for early diagnosis and rescue of immune suppression"
Main supervisor (co-supervisor Dr. Matt Morgan)
EU € 97,727 (12 months)
2017
MRC Proximity to Discovery Scheme (Biomedical Catalyst)
"Rapid detection and characterisation of life-threatening neurological infections"
Co-applicant (Lead applicant: Prof. Ian Weeks; co-applicant: Prof. William Gray)
£ 24,161 (6 months)
2017
Life Sciences Bridging Fund Wales, Pathfinder Grant
"Development of rapid in vitro diagnostic tests for early detection and characterisation of infection"
Co-applicant (Lead applicant: Prof. Ian Weeks; co-applicants: Prof. Nicholas Topley, Dr. Fraser Logue)
£ 74,554 (12 months)
2016-2019
MRC research grant
"Innate pathogen sensing by local unconventional T cells during microbial infections"
Principal Applicant (co-applicants: Prof. Donald Fraser, Prof. David Price, Dr. Kristin Ladell, Prof. Phil Taylor, Prof. Jamie Rossjohn)
£ 660,663 (36 months)
2016-2019
Health and Care Research Wales, Clinical Research Time Award (to Dr. Matt Morgan)
Academic Supervisor
£ 66,535 (36 months)
2016
Wellcome Trust ISSF Seedcorn Award
"γδ T-cell-mediated polarisation of CD4+ T-cell responses: implications for Crohn's disease"
Principal Applicant (co-applicants: Prof. Bernhard Moser, Dr. Andrew Stagg, Dr. James Lindsay)
£ 34,000 (6 months)
2016
Cardiff Incoming Visiting Fellowship (to Prof. Thomas Herrmann)
Principal Applicant
£ 5,500 (3 months)
2015-2018
MRC PhD Studentship (to Amy Brook)
"Pathogen-specific microRNA signatures during acute peritoneal infection"
Principal Applicant (co-applicants: Prof. Donald Fraser, Dr. Timothy Bowen)
£ 60,000 (36 months)
2015-2018
MRC PhD Studentship (to Ariadni Kouzeli)
"Use of human gamma/delta T-APCs in anti-tumour immunity"
Co-applicant (Principal applicant: Prof. Bernhard Moser; co-applicant: Prof. Andrew Godkin)
£ 60,000 (36 months)
2015-2018
Tenovus PhD Studentship (to Teja Rust)
"Human gamma/delta T-APCs: Processing of tumour antigens and induction of anti-tumour immunity"
Co-applicant (Principal applicant: Prof. Bernhard Moser; co-applicant: Prof. Awen Gallimore)
£ 89,780 (36 months)
2015-2018
Health and Care Research Wales, Wales Cancer Research Centre project grant
"Preclinical models for novel immunotherapies"
Principal Applicant (co-applicants: Prof. Awen Gallimore, Prof. Bernhard Moser, Prof. Andrew Godkin, Dr. Ann Ager)
£ 110,000 (36 months)
2015-2020
Health and Care Research Wales
"Wales Kidney Research Unit"
Co-applicant (Principal Applicant: Prof. Donald Fraser; with co-applicants across Cardiff, Newport, Swansea and Bangor)
£ 2,000,000 (60 months)
2015-2016
Kidney Research UK, Project Grant
"Rapid detection of infection and improving survival in dialysis patients: the role of unconventional T-cell driven inflammatory responses"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Bernhard Moser, Dr. Kieron Donovan, Prof. Donald Fraser)
£ 199,218 (24 months)
2014-2015
MRC-Confidence in Concept Scheme (Biomedical Catalyst)
"Point-of-care diagnosis of acute sepsis"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Paul Davis, Dr. Peter Morgan, Dr. Tamas Szakmany, Dr. Matt Morgan)
£ 44,935 (12 months)
2014
Severnside Alliance for Translational Research (SARTRE), Health Technology Challenge Project Award
"Point-of-care diagnosis of bloodstream infections"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Judith Hall, Prof. Paul Davis)
£ 24,912 (6 months)
2014
British Society for Immunology
BSI Travel Awards to Chris Tyler, Hung-Chang Chen, Matt Morgan and Matthias Eberl
gamma/delta T Cell Conference in Chicago, USA, 16-18 May 2014
£ 4,000
2013-2016
EU FP7 Marie Curie Initial Training Network, ITN 287813
"European Training and Research in Peritoneal Dialysis (EuTRiPD)"
PhD Supervisor (in collaboration with academic centres in Amsterdam, Berlin, Cardiff, Heidelberg, Madrid, Poznan, Strasbourg, Vienna; industrial partners: Zytoprotect, Baxter, Abbott; and Dutch Kidney Foundation, Kidney Research UK, EuroPD)
EU € 3,140,988 in total; € 517,568 of which to Cardiff University (48 months)
2013-2016
NIHR Invention for Innovation (i4i) Early Stage Product Development Award
"Rapid, non-invasive tests for acute bacterial infections based on pathogen specific immune fingerprints"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Ian Weeks, Prof. Chris Butler, Dr. Eryl Cox, Prof. Paul Davis)
£ 421,961 (30 months)
2013-2014
NISCHR/Wellcome Trust ISSF Seedcorn/Feasibility Grant
"Defining pathogen-specific responses in acute infection: development of point-of-care tests for bacterial identification"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Dr. Kieron Donovan, Dr. Julian Marchesi, Dr. James Chess)
£ 49,972 (12 months)
2013
NISCHR Academic Health Science Collaboration Equipment Call
Co-applicant (lead applicant: Dr. Kieron Donovan)
£ 5,000
2013
Cancer Research UK, Cardiff CR-UK Centre Development Fund
"Overcoming the resistance of breast cancer stem cells to novel immunotherapies"
Principal Applicant (co-applicants: Dr. Richard Clarkson, Hung-Chang Chen)
£ 4,950 (12 months)
2012-2015
MRC PhD Studentship (to Chris Tyler)
"Control of alpha/beta T cell responses by human gamma/delta T-APCs"
Principal Applicant (co-applicant: Prof. Bernhard Moser)
£ 60,000 (36 months)
2012
British Society for Immunology
BSI Travel Awards to Martin Davey, Joanne Welton and Chan-Yu Lin
gamma/delta T Cell Conference in Freiburg, Germany, 31 May-2 June 2012
£ 2,100
2011-2015
Tenovus PhD Studentship (to Hung-Chang Chen)
"Human gamma/delta T cells for immunotherapy of breast cancer"
Principal Applicant (co-applicant: Dr. Richard Clarkson)
£ 89,993 (45 months)
2010-2013
Welsh Assembly Government, Health Research Award
"Improving patient outcomes from peritoneal dialysis related infections"
Principal co-applicant (Lead applicant: Dr. Gareth Roberts; co-applicants: Prof. Nicholas Topley, Prof. Aled Phillips)
£ 207,325 (45 months)
2010
Wellcome Trust, Biomedical Vacation Scholarship (to Sarah Rollason)
"gamma/delta T cells for cancer immunotherapy"
Principal applicant
£ 1,080 (6 weeks)
2010
Cancer Research UK, Cardiff CR-UK Centre Development Fund
Principal Applicant (co-applicants: Prof. Malcolm Mason, Prof. Peter Barrett-Lee)
£ 4,940 (9 months)
2010
British Society for Immunology
BSI Travel Awards to Raj Bansal, Martin Davey
gamma/delta T Cell Conference in Kiel , Germany, 19-21 May 2010
£ 1,000
2009-2013
Baxter Healthcare, Renal Discoveries Extramural Grant
"T cells, monocytes and neutrophils: detrimental crosstalk in peritoneal dialysis-related infection"
Principal Applicant (co-applicant: Prof. John D. Williams)
US $ 374,947 (48 months)
2009-2012
Cancer Research UK, Project Grant
"The functional plasticity of gamma/delta T cells and their exploitation in cancer therapy"
Principal Applicant (co-applicants: Prof. Malcolm Mason, Prof. Peter Barrett-Lee)
£ 170,067 (42 months)
2009-2010
Breast Cancer Campaign, Small Pilot Grant
"The role of TRAIL in human gamma/delta T cell-mediated cytotoxicity toward breast cancer cells"
Principal Applicant (co-applicant: Dr. Richard Clarkson)
£ 19,944 (12 months)
2008-2010
Welsh Assembly Government, MRC Health Research Partnership Award
"The role of T cells in peritoneal dialysis-related inflammation and infection"
Principal Applicant (co-applicant: Prof. Nicholas Topley)
£ 209,660 (27 months)
2007-2010
MRC Studentship (to Raj Bansal)
"B cell help provided by human gamma/delta T cells"
Principal Applicant (co-applicant: Prof. Bernhard Moser)
£ 55,050 (36 months)
2007-2011
Research Councils UK
RCUK Fellowship in Translational Research in Experimental Medicine
£ 125,000 (60 months)
2007
Wellcome Trust, 'Value in People' Award
"Cells in bridging innate and adaptive immune responses"
Principal Applicant (co-applicant: Prof. Paul Morgan)
£ 34,786 (12 months)
Teaching
In order to overcome the awe-inspiring complexity of the immune system and press it into digestible portions, immunology teaching is often in the danger of over-simplifying scenarios and/or following temporary fashions. The main challenges are to keep up abreast with the latest literature and incorporate recent advances into the lessons; to transport one’s own enthusiasm for science to the students; to demonstrate that even the most complex mechanisms can be of enormous clinical relevance in health and disease; and to confront students with standard methods in diagnostic and research labs, but also to make them aware of the possibilities of modern technology. My goal is to educate open-minded and critical students that are provided with all the scientific but also interpersonal tools required for being capable of questioning contemporary points of view and solving new problems.
I am committed to supporting the C21 medical curriculum by teaching, learning and professional updating. I contribute to effective small group teaching within the Year 2 SSC module “Interactive Immunology” every year and for Year 1 SSC literature reviews, and have taught in modules on immunopathology/immunotherapeutics and on biomarkers/diagnostics to Year 3 and intercalated students, and given small group tutorials to Year 1 students. I am also involved in the MSc "Applied and Experimental Clinial Immunology", and since 2010 have been acting as Personal Tutor/Academic Mentor for medic undergraduates.
I have trained and mentored undergraduate and postgraduate students in the laboratory, including work experience and summer students, and internship students from France and Germany, and have trained PhD students from the UK, Italy, Greece, Slovenia, Netherlands, Poland and Taiwan in my laboratory. I have supervised eleven and co-supervised a further five PhD students, all of whom completed, or are on course to complete, their PhD within four years.
I have served on the annual appraisal panels for >50 PhD and MD students since 2014, and have been appointed as internal examiner and viva chair of PhD theses at Cardiff University and as external examiner of PhD theses in the UK, Ireland, Austria, France, Belgium, Italy and Portugal.
Biography
Career profile
- since 2018
Professor of Translational Immunology, Division of Infection & Immunity, School of Medicine, Cardiff University
- 2015-2018
Reader, Division of Infection & Immunity, School of Medicine, Cardiff University
- 2011-2015
Senior Lecturer, Cardiff Institute of Infection & Immunity, School of Medicine, Cardiff University
- 2007-2011
RCUK Fellow in Translational Research in Experimental Medicine, School of Medicine, Cardiff University
- 2005-2006
Postdoc, Institute of Cell Biology, University of Bern (Switzerland)
Lab: Prof Bernhard Moser
- 2000-2005
Postdoc, Institute of Biochemistry, School of Medicine, University of Giessen (Germany)
Lab: Dr Hassan Jomaa
- 1998-2000
Postdoc, Department of Biology, University of York (UK)
Lab: Prof Alan Wilson
- 1995-1998
PhD Student, Institute of Biochemistry, School of Medicine, University of Giessen (Germany)
Lab: Prof Ewald Beck
Honours and awards
- 2022: Microbiology Outreach Prize, Microbiology Society (to Dr Jon Tyrrell on behalf of the 'Superbugs' team)
- 2021: Poster Prize "Education & Public Engagement", British Society for Immunology (on behalf of the 'Superbugs' team)
- 2018: Promotion to Personal Chair, Cardiff University
- 2015: Promotion to Reader, Cardiff University
- 2011: Promotion to Senior Lecturer, Cardiff University
- 2009: Best Free Communications Prize, European Peritoneal Dialysis Meeting, Strasbourg, France
- 2007: RCUK Fellowship in Translational Research in Experimental Medicine
- 2007: Wellcome Trust 'VIP' Award
Professional memberships
- British Society for Immunology (BSI):
Public Engagement Secretary, since Jan 2023;
Board of Trustees, 2017-2023;
Regional Representative for Wales, BSI Forum, 2009-2016;
Chairman of the South Wales Immunology Group, 2007-2015;
Full member since 1998
Committees and reviewing
Leadership roles
- since 2020: Joint Academic Lead for Public Involvement and Engagement, School of Medicine, Cardiff University
- since 2015: Engagement Lead, Systems Immunity Research Institute, Cardiff University
- since 2014: Chair of PhD Appraisal Panels, Infection & Immunity, Cardiff University
- since 2011: Founder and Administrator, γδ T Cell Forum
- since 2009: Web Editor, Infection & Immunity, Cardiff University
PhD examiner
- Cardiff University
- King's College London
- Trinity College Dublin, Ireland
- National University of Ireland, Maynooth
- University of Antwerp, Belgium
- University of Bordeaux, France
- Université Libre de Bruxelles, Belgium
- University of Lisbon, Portugal
- University of Palermo, Italy
- Medical University of Vienna, Austria
Reviewer for funding bodies
- AERES - Evaluation Agency for Research and Higher Education, France
- ATIP-Avenir (CNRS/Inserm), France
- Barts and The London Charity, UK
- BBSRC - Biotechnology and Biological Sciences Research Council, UK
- Boehringer Ingelheim Fonds, Germany
- Breast Cancer Now, UK
- Cancer Research UK
- Crohn’s in Childhood Research Association (CICRA), UK
- Crohn's and Colitis UK
- Deutsche Forschungsgemeinschaft (DFG), Germany
- Dutch Cancer Society (KWF), Netherlands
- Dutch Research Council (NWO), Netherlands
- European Research Council (ERC)
- European Science Foundation (ESF)
- Fondation pour la Recherche Médicale, France
- German-Israeli Foundation for Scientific Research and Development
- Institut National du Cancer (INCa), France
- Kay Kendall Leukaemia Fund, UK
- Kidney Research UK
- King’s Health Partners R&D Challenge Fund, UK
- MRC - Medical Research Council, UK
- Ministry of Science, Technology and Space, Israel
- Multiple Sclerosis Society, UK
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), UK
- National Institute for Health Research (NIHR), UK
- Research Council of Norway
- Research Grants Council, Hong Kong
- University College Cork, Ireland
- University of Liège, Belgium
- Wellcome Trust, UK
- Wilhelm Sander Foundation, Germany
Reviewer for scientific journals
- American Journal of Physiology – Renal Physiology
- Blood
- Bone
- BMC Immunology
- Breast Cancer Research
- Cancer Immunology Immunotherapy
- Cancer Research
- Carcinogenesis
- Cell Biochemistry & Function
- Cell Reports
- Cellular Immunology
- Chronobiology International
- Clinical Cancer Research
- Clinical and Developmental Immunology
- Clinical and Experimental Immunology
- Clinical and Experimental Medicine
- Communications Biology
- Current Cancer Drug Targets
- Current Immunology Reviews
- Cytokine
- Discovery Immunology
- EBioMedicine
- EMBO Reports
- European Journal of Clinical Microbiology & Infectious Diseases
- European Journal of Immunology
- Experimental Parasitology
- FASEB Journal
- FEBS Journal
- Frontiers in Immunology
- Haematologica
- Human Immunology
- Immunology
- Immunology and Cell Biology
- Immunology Letters
- Infection and Immunity
- International Immunology
- International Journal of Artificial Organs
- International Journal of Immunogenetics
- International Urology and Nephrology
- JCI Insight
- Journal of the American Chemical Society
- Journal of the American Society of Nephrology
- Journal of Biological Chemistry
- Journal of Biological Regulators and Homeostatic Agents
- Journal of Clinical Investigation
- Journal of Experimental Medicine
- Journal of Immunology
- Journal of Infectious Diseases
- Journal of Leukocyte Biology
- Journal of Medicinal Chemistry
- Journal of Molecular Medicine
- Journal of Translational Medicine
- Kidney International
- Malaria Journal
- Microbes and Infection
- Molecular Immunology
- Mucosal Immunology
- Nature
- Nature Communications
- Nature Reviews Immunology
- Nephrology, Dialysis, Transplantation
- OncoImmunology
- Oncology Reviews
- Parasite Immunology
- Peritoneal Dialysis International
- PLoS ONE
- PLoS Pathogens
- Science Translational Medicine
- Scientific Reports
- Trends in Immunology
- Trends in Molecular Medicine
- Trends in Parasitology
Supervisions
Current supervision
Kirsty Emery
Research student
Daniel Griffiths
Research student
Kate Davies
Graduate Tutor
Siva Oruganti
Research student
Past projects
PhD students
Linda Moet (PhD 2023):
“Elucidating an immune metabolite pathway in sepsis”
(Co-supervisor; main supervisor Peter Ghazal, with Valerie O'Donnell)
Ross Burton (PhD 2023):
“Identifying immunological biomarkers of sepsis using cytometry bioinformatics and machine learning”
(Main supervisor; with Andreas Artemiou, Peter Ghazal, Matt Morgan)
Teja Rus (PhD 2021):
“Generation of experimental tools for studying tumour antigen processing by human γδ T-APCs: Processing of tumour antigens and induction of anti-tumour immunity”
(Co-supervisor; main supervisor Bernhard Moser)
Ariadni Kouzeli (PhD 2020):
“CXCL14 function and target cells in healthy tissues”
(Co-supervisor; main supervisor Bernhard Moser)
Amy Brook (PhD 2019):
“Local microRNAs in peritoneal dialysis patients with acute peritonitis”
(Main supervisor; with Donald Fraser, Tim Bowen)
Chris Tyler (PhD 2016):
“Control of CD4+ T cell responses by γδ T-APCs”
(Main supervisor; with Bernhard Moser)
Anna Rita Liuzzi (PhD 2015):
“Unconventional T-cell driven inflammatory responses during acute peritonitis: implications for diagnosis and therapy of peritoneal dialysis patients”
(Main supervisor; with Tim Bowen)
Hung-Chang Chen (PhD 2015):
“Human γδ T cell-based immunotherapy for breast cancer”
(Main supervisor; with Richard Clarkson)
Matt Morgan (PhD 2014):
“Immune fingerprinting in acute severe sepsis”
(Co-supervisor; main supervisor Judith Hall)
Luke Piggott (PhD 2012):
“Investigating the therapeutic potential of cellular FLICE-like inhibitory protein and TRAIL in preclinical models of breast cancer”
(Co-supervisor; main supervisor Richard Clarkson)
Chan-Yu Lin (PhD 2012):
“The role of γδ T cells in peritoneal dialysis-associated bacterial infection”
(Main supervisor; with Nick Topley)
Martin Davey (PhD 2012):
“Cellular crosstalk of human Vγ9/Vδ2 T cells, neutrophils and monocytes in response to bacterial infections”
(Main supervisor; with Bernhard Moser)
Raj Bansal (PhD 2012):
“B cell help provided by human γδ T cells”
(Main supervisor; with Bernhard Moser)
MD students
Nicola Reeves (MD 2021):
“The impact of standardising intra-operative variables on the incidence of surgical site infections in colorectal surgery in Wales”
(Co-supervisor; main supervisor Jared Torkington, with Ian Weeks)
MPhil students
Emily Jacob (MPhil 2022):
“Immune fingerprinting of bacterial infections in decompensated cirrhosis”
(Co-supervisor; main supervisor Thomas Pembroke)
MSc students
Al-Motaz Rizek (MSc 2024):
“Modulation of T-cell mediated humoral immunity during severe bacterial infection”
(Co-supervisor; main supervisor James McLaren, with Kate Davies)
Ogbukagu Chioma (MSc 2024):
“Determining academic attitudes to public engagement in antimicrobial resistance”
(Co-supervisor; main supervisor Jon Tyrrell)
Sona Galla (MSc 2024):
“Environmental screening for antimicrobial resistance (AMR) powered by impactful public engagement”
(Co-supervisor; main supervisor Jon Tyrrell)
Oluwatimilehin Okundalaye (MSc 2024):
“Enhancing understanding and prevention of antimicrobial resistance (AMR) in schools through gamified learning”
(Co-supervisor; main supervisor Jon Tyrrell)
Amalraj Eyyath Veettil (MSc 2024):
“Development and evaluation of digital education material to improve public awareness of infection control”
(Co-supervisor; main supervisor Jon Tyrrell)
Josephine Banda (MSc 2023):
“Exploring the immunomodulatory landscape in asymptomatic P. falciparum infection”
(Co-supervisor; main supervisor Ian Humphreys)
Lucy Sheikh (MSc 2023):
“Immunophenotyping dysfunctional antimicrobial T cells during sepsis”
(Co-supervisor; main supervisor James McLaren)
Haritha Ayanikkad (MSc 2023):
“A study on public engagement to enhance wareness on food hygiene and microbial literacy in school children”
(Co-supervisor; main supervisor Jon Tyrrell)
Vasudev Gopakumar (MSc 2023):
“Public engagement in hygiene and microbiology among young children through successful interventions”
(Co-supervisor; main supervisor Jon Tyrrell)
Chiamaka Nnamdi (MSc 2023):
“Creating awareness of antimicrobial resistance to children aged 7 to 14 using Staphylococcus aureus as a case study”
(Co-supervisor; main supervisor Jon Tyrrell)
Rachel Oyebode (MSc 2023):
“Creating awareness of antimicrobial resistance in children using Staphylococcus aureus as a case study”
(Co-supervisor; main supervisor Jon Tyrrell)
Katherine Stanswood (MSc 2022):
“Immunophenotyping mechanisms of T cell dysfunction during the onset of sepsis”
(Co-supervisor; main supervisor James McLaren)
Engagement
I am passionate about engaging and involving the public in research and disseminate relevant findings to specialist and lay audiences.
As Engagement Lead for the Systems Immunity Research Institute since 2015, and Academic Lead for Public Involvement and Engagement for the School of Medicine at Cardiff University since 2020 (jointly with Dr Natalie Joseph-Williams), I conceive, oversee and coordinate a wide range of public engagement and involvement activities, and aim to reach out to all stake-holders in our research – patients, health care providers, schools, policy makers, media, funders, industry and the general public.
I work closely with the School of Medicine Engagement Manager Sarah Hatch, the Lead Public Partners Sarah Peddle and Sienna-Mae Yates and the newly formed PPIE Committee from across the School of Medicine. Together we have developed a 5-year Action Plan and Infographic to help us embed a culture of public engagement and involvement in all research and teaching activities at the School of Medicine, aligned with the UK Standards for Public Involvement and the National Coordinating Centre for Public Engagement.
I established and chair a Lay Faculty for the Systems Immunity Research Institute consisting of members of the public who provide valuable feedback on research proposals, study protocols, consent forms, news items and press releases, and help foster a close dialogue between local scientists and the wider public. This Lay Faculty has developed into a flagship involvement activity at Cardiff University and a model for similar approaches elsewhere.
In addition to facilitating and promoting a wide range of smaller and larger engagement and involvement activities by colleagues across the Systems Immunity Research Institute and the School of Medicine, over the past years I directly contributed to activities such as
- Developing an interactive educational resource ('Superbugs') for key stage 2/3 school children (years 3-9), co-produced with teachers from primary and secondary schools and made available in English, Welsh, Irish and Scottish Gaelic
- Establishing a partnership of schools in the UK and Ireland with schools in Tanzania, to learn with and from each other, to increase understanding and raise awareness of infection, hygiene and antimicrobial resistance, in collaboration with RBA Initiative.
- Setting up an interactive pop-up science shop in a repurposed retail unit in the St David's Dewi Sant shopping centre in Cardiff, one of the busiest in the UK, attracting >6,600 visitors over a period of two weeks
- Participating in science festivals, including the Cardiff Science Festival 2020, Merthyr Tydfil Science Festival 2021 (virtual) and the Zaporizhzhia 'Night of Science' 2022 (virtual, in English and Ukrainian)
- Showcasing Cardiff research on several occasions at Techniquest, the local Science museum in Cardiff
- Promoting the importance of international research and collaboration for Cardiff University, Wales and the UK at receptions in the National Assembly for Wales and the House of Commons
- Hosting the MP for Cardiff Central, Jo Stevens, at the Annual Infection & Immunity Meeting 2017 and during our 'Superbugs' pop-up science shop event in 2019
- Supporting campaigns by organisations such as #WeAreInternational, @the3million and Scientists4EU to raise awareness for international students, EU citizens' rights and EU funding, and their relevance for UK research, education and innovation
- Creating educational computer games for primary schools
- Running a Cardiff-wide bus stop poster campaign to promote local research
- Celebrating diversity and equality across Infection & Immunity, the School of Medicine and Cardiff University as a whole
- Setting up a dedicated 'Superbugs' TikTok channel for infection, antimicrobial resistance, COVID-19 and related topics
- Collaborating with BBC Wales on a programme about sepsis involving BBC weatherman Derek Brockway, a 1 hour long documentary on "The Truth About... Boosting Your Immune System", and on sourcing laboratory equipment and props for the BBC Dr Who Christmas Special 2014
As web editor of the Systems Immunity URI and its predecessor, the i3-IRG, over the past >12 years, I have substantially improved the visibility of local research, teaching, innovation and engagement, accompanied by successful social media accounts (>2,600 Twitter followers).
I also founded the interactive ‘γδ T cell Forum’, which has >3,300 followers from >50 countries and has developed into a key networking platform in the field of unconventional T cells, including running the monthly ‘γδ T cell Club’ webinar series.
Through my participation in the core activities of the British Society for Immunology (BSI), the largest immunological society in Europe, I directly promote immunology-related research, public engagement and education in Wales, the UK and beyond. I was elected as BSI Trustee in 2017, after serving two terms as Regional Representative for Wales on the BSI Forum (2010-2016), the Society’s ‘think tank’. As one of 14 Trustees, I was directly responsible for the effective operation of the Society, with regard to finance, governance, strategy and supervision of its CEO. As of January 2023, I serve as Public Engagement Secretary and member of the BSI Forum. As Chairman of the BSI South Wales regional group (2007-2015), I established Cardiff as one of the most active and visible regional groups in the UK, increased its annual budget eight-fold, and created the prestigious annual Jonathan Boulter Memorial Lecture given by the leading immunologists in the world.
Grant support for public engagement and involvement:
2025
Cardiff University, UKRI Harmonised IAA Strategic Impact Fund.
"Improving the impact of research and teaching through a tailored training programme in patient and public involvement and engagement"
Co-applicant (Lead applicant: Natalie Joseph-Williams; with Sarah Hatch, Claire Nollett, Justine Bold, Sarah Peddle, Jim Fitzgibbon, Athanasios Hassoulas, Susan Monkton)
£ 10,000
2024-2025
PAR Foundation (Sweden).
"A Superbugs Tanzania partnership – Learning from and with each other"
Lead applicant (with Jonathan Tyrrell, Sarah Hatch, Claire Nollett, Michael Mosha, Erick Venant, Oliva Minja)
SEK 300,000
2024
Cardiff University, Civic Insights bursaries (to Friday Cox, Kashia Dias).
Lead applicant: “Superbugs – The microbial world in, on and around us”
£ 200
2023
Systems Immunity Research Institute.
"Learning together about infection and hygiene – A Superbugs partnership between schools in Wales and Tanzania"
Lead applicant (with Jonathan Tyrrell, Sarah Hatch, Claire Nollett, Michael Mosha, Erick Venant, Oliva Minja)
£ 1,126
2023
Microbiology Society, Education and Outreach Grant.
"Learning together about infection and hygiene – A Superbugs collaboration in Tanzania"
Co-applicant (Lead applicant: Jonathan Tyrrell; with Sarah Hatch, Michael Mosha, Erick Venant, Oliva Minja)
£ 996
2023
An Chomhairle um Oideachas Gaeltachta agus Gaelscolaíochta (COGG).
Teaching and learning resource funding scheme 2023
Lead applicant (with Jonathan Tyrrell, Sarah Hatch, Jack Ó Drisceoil, Margaret Dunne, Máire Nic Eachmharcaigh)
€ 8,588
2021-2023
British Society for Immunoloy, Communicating Immunology grant.
"Superbugs – An educational resource for school children in the UK and Ireland"
Lead applicant (with Jonathan Tyrrell, Sarah Hatch, Jenny Mannion, Elaine Nic Réamoinn)
£ 1,000
2020-2021
Wellcome Trust ISSF3 Public Engagement Co-production Award.
"Superbugs 2: Digital Dissemination!"
Co-applicant (Lead applicant: Jonathan Tyrrell; with Sarah Hatch, Christie Conlon, Mike Roberts)
£ 12,357
2019-2020
Wellcome Trust ISSF3 Public Engagement Proof-of-Concept Award.
"Science Stitches – communicating science through fashion"
Co-applicant (Lead applicant: Andreia de Almeida; with Ruth Potts, Emma Yhnell, Rachel Stanton, Riccardo Bonsignore, Zoe Hudson, Julia Harris, Sarah Valentin)
£ 7,198
2019
Wellcome Trust ISSF3 Public Engagement Proof-of-Concept Award
"A Pop-up Science Shop!"
Co-applicant (Lead applicant: Jonathan Tyrrell; with Sarah Hatch, Ali Aboklaish)
£ 7,440
2018
Systems Immunity Research Institute Engagement Grant
"Superbugs - The End of Modern Medicine As We Know It?"
Lead applicant (with Micalea Gal, Sarah Hatch)
£ 2,160
2018
Systems Immunity Research Institute Engagement Grant
"Project Sepsis – Sepsis Patient Public Engagement Centre"
Co-applicant (Lead applicant: Widad Dantoft; with Rhian Thomas-Turner, Peter Ghazal, Valerie O’Donnell)
£ 1,890
2017
Systems Immunity Research Institute Engagement Grant
"Learning by playing: developing immunology-based computer games"
Lead applicant (with Mike Reddy, Philip Taylor, Simone Cuff)
£ 1,998
2016
Systems Immunity Research Institute Engagement Grant
"What am I? Who am I?"
Co-applicant (Lead applicant: Awen Gallimore; with Lewis Evans)
£ 600
2016
Systems Immunity Research Institute Engagement Grant
"It’s not rocket science!"
Co-applicant (Lead applicant: David Cole; with Ellyn Hughes)
£ 3,152
Contact Details
+44 29206 87011
Henry Wellcome Building for Biomedical Research, Room 3F08, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN
Research themes
Specialisms
- Immunology
- Infectious diseases
- Public engagement and involvement
- T cell immunity
- Biomarkers
