![David Gillespie BSc, PhD](https://profiles-cardiff.imgix.net/attachments/3572?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
David Gillespie
(e/fe)
BSc, PhD
Cyfarwyddwr Treialon Heintio, Llid ac Imiwnedd a Phrif Gymrawd Ymchwil
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Fi yw Cyfarwyddwr yr Is-adran Treialon Heintio, Llid ac Imiwnedd ac yn Brif Gymrawd Ymchwil yn y Ganolfan Treialon Ymchwil.
Yn fy rôl fel Cyfarwyddwr, rwy'n darparu uwch arweinyddiaeth ar draws ein Is-adran Heintio, Llid ac Imiwnedd ac rwy'n gyfrifol am bortffolio mawr o dreialon ac astudiaethau eraill sydd wedi'u cynllunio'n dda sy'n ymdrin â'r themâu canlynol:
- Clefydau heintus
- Anhwylderau fasgwlaidd
- Amodau llidiol cyfryngol immune
Mae gen i Gymrodoriaeth Ymchwil Iechyd pum mlynedd a ddyfarnwyd gan Ymchwil Iechyd a Gofal Cymru i ymchwilio i'r defnydd o Prophylaxis Cyn-Exposure (PrEP) mewn unigolion sydd mewn perygl o gaffael HIV sy'n byw yng Nghymru.
Rwyf hefyd yn Arweinydd Academaidd ar gyfer Ymgysylltu â Rhanddeiliaid yn elfen Treialon Cymru.
Mae fy nghefndir mewn Ystadegau Meddygol, ac rwyf wedi bod yn gweithio ar ddylunio, cynnal, dadansoddi ac adrodd ar hapdreialon ac astudiaethau eraill sydd wedi'u cynllunio'n dda ers 2007. Cwblheais fy PhD ar ddiwedd 2016, gyda fy nhraethawd ymchwil yn dwyn y teitl " Glynu wrth Feddyginiaeth mewn Ymchwil Glinigol a Heriau Methodolegol Cysylltiedig".
Yn glinigol, mae fy niddordebau ymchwil yn canolbwyntio ar ddefnyddio meddyginiaeth ddarbodus ym maes clefydau heintus, a gellir rhannu fy ngwaith yn fras yn ddau faes allweddol:
- Glynu wrth feddyginiaeth - yn benodol, ffyrdd y mae cadw at feddyginiaeth yn gysyniadol, mesuredig, a modelu
- Datblygu a gwerthuso ymyriadau stiwardiaeth gwrthficrobaidd
Mae fy meysydd o ddiddordeb methodolegol yn cynnwys:
- Treialon a methodoleg ymchwil gyffredinol (gwella'r ffyrdd yr ydym yn cynnal hapdreialon ac astudiaethau eraill sydd wedi'u cynllunio'n dda)
- modelu achosol (modelu dulliau sy'n anelu at ateb cwestiynau achosol, yn hytrach na chymdeithasu'n unig)
- Data ar goll (atal, a gosod modelau pan fydd data ar goll).
Cyhoeddiad
2024
- Khammas, Z., Gillespie, D., Williams, A. D. N., Nicholls, J. and Wood, F. 2024. HIV Pre‐Exposure Prophylaxis (PrEP) users' experiences of PrEP access, sexual behaviour, and well‐being during the COVID‐19 pandemic: A Welsh qualitative study. Health Expectations 27(5), article number: e70064. (10.1111/hex.70064)
- Johansen, E., Nielsen, H., Gillespie, D., Aabenhus, R. and Hansen, M. P. 2024. The optimal antibiotic treatment duration for community-acquired pneumonia in adults diagnosed in general practice in Denmark (CAP-D): an open-label, pragmatic, randomised controlled trial. Trials 25, article number: 627. (10.1186/s13063-024-08477-z)
- Langdon, P. E. et al. 2024. Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities: The BEAMS ‐ ID feasibility study. Journal of Applied Research in Intellectual Disabilities 37(5), article number: e13282. (10.1111/jar.13282)
- Lowe, J. et al. 2024. Azithromycin therapy for prevention of chronic lung disease of prematurity (AZTEC): a multicentre, double-blind, randomised, placebo-controlled trial. The Lancet Respiratory Medicine 12(8), pp. 608-618. (10.1016/S2213-2600(24)00079-1)
- Lowe, J., Berrington, J., Gillespie, D., Turner, M. and Kotecha, S. 2024. Challenges of modulating the risk of bronchopulmonary dysplasia in clinical trials – Authors' reply. The Lancet Respiratory Medicine 12(8), article number: E44. (10.1016/S2213-2600(24)00173-5)
- Underwood, J., Griffiths, R., Gillespie, D., Akbari, A. and Ahmed, H. 2024. All-cause and infection-attributable mortality amongst adults with bloodstream infection—a population-based study. Open Forum Infectious Diseases 11(5), article number: ofae126. (10.1093/ofid/ofae126)
- Gillooly, A. et al. 2024. Behavioural activation for depressive symptoms in adults with severe to profound intellectual disabilities: Modelling and initial feasibility study. Journal of Applied Research in Intellectual Disabilities 37(2), article number: e13197. (10.1111/jar.13197)
- Randell, E. et al. 2024. Exploring critical intervention features and trial processes in the evaluation of sensory integration therapy for autistic children. BMC Trials 25(1), article number: 131. (10.1186/s13063-024-07957-6)
- Scior, K. et al. 2024. Digital adaptation of the Standing up for Myself intervention in young people and adults with intellectual disabilities: the STORM feasibility study. Project Report. [Online]. National Institute for Health Research. Available at: https://doi.org/10.3310/NCBU6224
- Langdon, P. E. et al. 2024. Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities: the BEAMS-ID feasibility study. Health Technology Assessment 28(72), pp. 1-147. (10.3310/mwtq5721)
2023
- Taylor, E. L. et al. 2023. Mapping and identifying service models for community-based services for children with intellectual disabilities and behaviours that challenge in England. BMC Health Services Research 23(1), article number: 1354. (10.1186/s12913-023-10388-9)
- Gillespie, D. et al. 2023. Gut microbiology of UK care home residents: cross-sectional analysis from a randomised controlled trial. Clinical Microbiology and Infection 29(11), pp. 1437-1442. (10.1016/j.cmi.2023.08.001)
- Boateng, I. et al. 2023. Using microbiological data to improve the use of antibiotics for respiratory tract infections: A protocol for an individual patient data meta-analysis. PLoS ONE 18(11), article number: e0294845. (10.1371/journal.pone.0294845)
- Courtenay, M., Gillespie, D. and Lim, R. 2023. Patterns of GP and nurse independent prescriber prescriptions for antibiotics dispensed in the community in England: a retrospective analysis. Journal of Antimicrobial Chemotherapy 78(10), pp. 2544-2553., article number: dkad267. (10.1093/jac/dkad267)
- Roberts-Tyler, E. J., Roberts, S. E., Watkins, R., Hughes, J. C., Hastings, R. P. and Gillespie, D. 2023. Effects of implementation support on children?s reading outcomes following an online early reading programme: a cluster-randomised controlled trial. British Journal of Educational Technology 54(5), pp. 1373-1396. (10.1111/bjet.13312)
- Richardson, L. et al. 2023. Standing up for Myself (STORM): Adapting and piloting a web-delivered psychosocial group intervention for people with intellectual disabilities. Research in Developmental Disabilities 137, article number: 104496. (10.1016/j.ridd.2023.104496)
- Gillespie, D. et al. 2023. Between- and within-individual sociodemographic and psychological determinants of PrEP adherence among men who have sex with men prescribed a daily PrEP regimen in Wales. AIDS and Behavior 27, pp. 1564-1572. (10.1007/s10461-022-03890-4)
- Lau, T. et al. 2023. Perspectives of statistician, microbiologist, and clinician stakeholders on the use of microbiological outcomes in randomised trials of antimicrobial stewardship interventions. Antibiotics, article number: 885. (10.3390/antibiotics12050885)
- Pickles, T., Horton, M., Christensen, K. B., Phillips, R., Gillespie, D., Mo, N. and Choy, E. 2023. P035 Patient-reported outcome measures for rheumatoid arthritis disease activity: using Rasch measurement theory to achieve more meaningful measurement. Rheumatology 62(Supp 2) (10.1093/rheumatology/kead104.076)
- Hounkpatin, H. et al. 2023. Post-consultation acute respiratory tract infection recovery: a latent class informed analysis of individual patient data from randomised controlled trials and observational studies. British Journal of General Practice 73(728), pp. e196-e203. (10.3399/BJGP.2022.0229)
- Gillespie, D. et al. 2023. Psychometric Properties of an Adapted Stigma Scale and Experiences of Stigma Associated with HIV Pre-exposure Prophylaxis Use Among Men Who have Sex with Men: A Mixed Methods Study. AIDS and Behavior (10.1007/s10461-022-03967-0)
- Pickles, T., Horton, M., Christensen, K. B., Phillips, R., Gillespie, D., Mo, N. and Choy, E. 2023. Patient reported outcome measures for rheumatoid arthritis disease activity: using Rasch measurement theory and cognitive interviewing to achieve more meaningful measurement. Presented at: ACR Convergence 2023, San Diego, 10-15 November 2023, Vol. 75. Vol. Supp 9.
2022
- Evans, A., Mantzourani, E., Gillespie, D., Hughes, L., Sharpe, G. and Yip, N. 2022. Location, location, location: does providing public health services from community pharmacies contribute to tackling health inequalities?. Journal of Public Health, article number: fdac148. (10.1093/pubmed/fdac148)
- Phillips, R. et al. 2022. Perceived threat of COVID-19, attitudes towards vaccination, and vaccine hesitancy: A prospective longitudinal study in the UK. British Journal of Health Psychology 27(4), pp. 1354-1381. (10.1111/bjhp.12606)
- Williams, A. D. N., Wood, F., Gillespie, D., Couzens, Z., Hughes, K. and Hood, K. 2022. The relationship between HIV pre-exposure prophylaxis, sexually transmitted infections, and antimicrobial resistance: a qualitative interview study of men who have sex with men. BMC Public Health 22(1), article number: 2222. (10.1186/s12889-022-14645-0)
- Carvalho, M. J. et al. 2022. Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries. Nature Microbiology 7, pp. 1337-1347. (10.1038/s41564-022-01184-y)
- Reeve, N. F. et al. 2022. Myocardial infarction and stroke subsequent to urinary tract infection (MISSOURI): protocol for a self-controlled case series using linked electronic health records. BMJ Open 12, article number: e064586. (10.1136/bmjopen-2022-064586)
- Kotecha, S. J., Course, C. W., Jones, K. E., Watkins, W. J., Berrington, J., Gillespie, D. and Kotecha, S. 2022. Follow-up study of infants recruited to the randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants: study protocol for the AZTEC-FU study. Trials 23, article number: 796. (10.1186/s13063-022-06730-x)
- Milton, R. et al. 2022. Incidence and sociodemographic, living environment and maternal health associations with stillbirth in a tertiary healthcare setting in Kano, Northern Nigeria. Short title: Incidence and factors associated with stillbirth in Kano, Nigeria. BMC Pregnancy and Childbirth 22, article number: 692. (10.1186/s12884-022-04971-x)
- Gillespie, D. et al. 2022. PrEP use, sexual behaviour, and PrEP adherence among men who have sex with men living in Wales prior to and during the COVID-19 pandemic. AIDS and Behavior 26, pp. 2746-2757. (10.1007/s10461-022-03618-4)
- Lau, T. M. M., Lowe, J., Pickles, T., Hood, K., Kotecha, S. and Gillespie, D. 2022. AZTEC—azithromycin therapy for prevention of chronic lung disease of prematurity: a statistical analysis plan for clinical outcomes. Trials 23(1), article number: 704. (10.1186/s13063-022-06604-2)
- Milosevic, S. et al. 2022. Understanding the support experiences of families of children with autism and sensory processing difficulties: A qualitative study.. Health Expectations 25(3), pp. 1118-1130. (10.1111/hex.13465)
- Randell, E. et al. 2022. Sensory integration therapy for children with autism and sensory processing difficulties: the SenITA RCT. Health Technology Assessment 26(29) (10.3310/TQGE0020)
- Neill, R., Gillespie, D. and Ahmed, H. 2022. Variation in antibiotic treatment failure outcome definitions in randomised trials and observational studies of antibiotic pre-scribing strategies: A systematic review and narrative synthesis. Antibiotics 11(5), article number: 627. (10.3390/antibiotics11050627)
- Pickles, T. et al. 2022. P089 Patient-reported outcome measures for rheumatoid arthritis disease activity: a systematic review following COSMIN guidelines. Presented at: British Society for Rheumatology Annual Conference 2022, Glasgow, Scotland, 25-27 April 2022Rheumatology Supplement 1, Vol. 61. pp. keac133.088., (10.1093/rheumatology/keac133.088)
- Hoult, G., Gillespie, D., Wilkinson, T. M. A., Thomas, M. and Francis, N. A. 2022. Biomarkers to guide the use of antibiotics for acute exacerbations of COPD (AECOPD): a systematic review and meta-analysis. BMC Pulmonary Medicine 22(1), article number: 194. (10.1186/s12890-022-01958-4)
- Gillespie, D. et al. 2022. Experiences of men who have sex with men when initiating, implementing, and persisting with HIV pre-exposure prophylaxis. Health Expectations 25(4), pp. 1332-1341. (10.1111/hex.13446)
- Pickles, T. et al. 2022. Patient reported outcome measures for rheumatoid arthritis disease activity: a systematic review following COSMIN guidelines. RMD Open 8(1), article number: e002093. (10.1136/rmdopen-2021-002093)
- Lau, T. M. M., Daniel, R., Hughes, K., Wootton, M., Hood, K. and Gillespie, D. 2022. A systematic review investigating the use of microbiology outcome measures in randomized controlled trials evaluating antimicrobial stewardship interventions published between 2011 and 2021. JAC-Antimicrobial Resistance 4(1), article number: dlac013. (10.1093/jacamr/dlac013)
- Williams, A., Gillespie, D., Couzens, Z., Wood, F., Hughes, K. and Hood, K. 2022. Changing sexual behaviours amongst MSM during the COVID-19 restrictions in Wales: a mixed methods study. BMC Public Health 22(1), article number: 396. (10.1186/s12889-022-12821-w)
- Segrott, J. et al. 2022. Effectiveness of the strengthening families programme in the UK at preventing substance misuse in 10-14 year-olds: a pragmatic randomised controlled trial. BMJ Open 12(2), article number: e049647. (10.1136/bmjopen-2021-049647)
- Gillespie, D. et al. 2022. Associations with post-consultation health-status in primary care managed acute exacerbation of COPD. International Journal of Chronic Obstructive Pulmonary Disease 2022(17), pp. 383-394. (10.2147/COPD.S340710)
- Moody, G. et al. 2022. The READ-IT study protocol for a feasibility randomised controlled trial of using a support worker/family carer mediated online reading programme to teach early reading skills to adults with intellectual disabilities. Pilot and Feasibility Studies 8(1), article number: 13. (10.1186/s40814-022-00972-x)
- Milton, R. et al. 2022. Determinants of stillbirth from two observational studies investigating deliveries in Kano, Nigeria. Frontiers in Global Women's Health 2, article number: 788157. (10.3389/fgwh.2021.788157)
2021
- Coulman, E. et al. 2021. Early positive approaches to support (E-PAtS) for families of young children with intellectual disability: a feasibility randomised controlled trial. Frontiers in Psychiatry 12, article number: 729129. (10.3389/fpsyt.2021.729129)
- Ahmed, H., Gillespie, D. and Thomas-Jones, E. 2021. Effect of 7 vs 14 days of antibiotics among afebrile men with urinary tract infection. Journal of the American Medical Association 326(20), article number: 2080. (10.1001/jama.2021.16738)
- Phillips, R. et al. 2021. Cohort profile: The UK COVID-19 Public Experiences (COPE) prospective longitudinal mixed-methods study of health and well-being during the SARSCoV2 coronavirus pandemic. PLoS ONE 16(10), article number: e0258484. (10.1371/journal.pone.0258484)
- Read, S. et al. 2021. Normalisation process theory and the implementation of a new glaucoma clinical pathway in hospital eye services: perspectives of doctors, nurses and optometrists. PLoS ONE 16(8), article number: e0255564. (10.1371/journal.pone.0255564)
- Gillespie, D. et al. 2021. Early impact of COVID-19 social distancing measures on reported sexual behaviour of HIV pre-exposure prophylaxis users in Wales. Sexually Transmitted Infections 97, pp. 85-87. (10.1136/sextrans-2020-054598)
- Gillespie, D. et al. 2021. Associations with antibiotic prescribing for acute exacerbation of COPD in primary care: secondary analysis of a randomised controlled trial. British Journal of General Practice 71(705), pp. e266-e272. (10.3399/BJGP.2020.0823)
- Sands, K. et al. 2021. Characterization of antimicrobial resistant Gram-negative bacteria that cause neonatal sepsis in seven low and middle-income countries. Nature Microbiology 6, pp. 512–523. (10.1038/s41564-021-00870-7)
- Butler, C. C. et al. 2021. Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT. Efficacy and Mechanism Evaluation 8(7) (10.3310/eme08070)
- Stuart, B. et al. 2021. Delayed antibiotic prescribing for respiratory tract infections: an individual patient data meta-analysis. BMJ 372, article number: n808. (10.1136/bmj.n808)
- Castro-Herrera, V. M. et al. 2021. Combination of the probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis, BB-12 has limited effect on biomarkers of immunity and inflammation in older people resident in care homes: results from the Probiotics to Reduce Infections iN CarE home reSidentS Randomized, Controlled Trial. Frontiers in Immunology 12, article number: 643321. (10.3389/fimmu.2021.643321)
- Felloner, J. et al. 2021. A multi-stakeholder approach to the co-production of the research agenda for medicines optimisation. BMC Health Services Research 21, article number: 64. (10.1186/s12913-021-06056-5)
- M.Castro-Herrera, V. et al. 2021. Relationship between age, frailty, length of care home residence and biomarkers of immunity and inflammation in older care residents in the UK. Frontiers in Aging 2, article number: 599084. (10.3389/fragi.2021.599084)
2020
- Waterman, H. et al. 2020. Acceptability, adherence and economic analyses of a new clinical pathway for the identification of non-responders to glaucoma eye drops: a prospective observational study. British Journal of Ophthalmology 104(12), pp. 1704-1709. (10.1136/bjophthalmol-2019-315436)
- Francis, N. A. et al. 2020. Clinical features and c-reactive protein as predictors of bacterial exacerbations of COPD. International Journal of Chronic Obstructive Pulmonary Disease 2020, pp. 3147-3158. (10.2147/COPD.S265674)
- Lowe, J. et al. 2020. Study protocol: azithromycin therapy for chronic lung disease of prematurity (AZTEC) - a randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants. BMJ Open 10(10), article number: e041528. (10.1136/bmjopen-2020-041528)
- Alghamdi, S. et al. 2020. Prescribing trends over time by non-medical independent prescribers (NMIPs) in primary care settings across Wales (2011-2018): a secondary database analysis. BMJ Open 10, article number: e036379. (10.1136/bmjopen-2019-036379)
- Coulman, E. et al. 2020. The Early Positive Approaches to Support (E-PAtS) study: study protocol for a feasibility cluster randomised controlled trial of a group programme (E-PAtS) for family caregivers of young children with intellectual disability. Pilot and Feasibility Studies 6(1), article number: 147. (10.1186/s40814-020-00689-9)
- Phillips, R. et al. 2020. C-Reactive Protein-guided antibiotic prescribing for COPD exacerbations: a qualitative evaluation. British Journal of General Practice 70(696), pp. e505-e523. (10.3399/bjgp20X709865)
- Butler, C. C. et al. 2020. Effect of probiotic use on antibiotic administration among care home residents: a randomized clinical trial. Journal of the American Medical Association 324(1), pp. 47 - 56. (10.1001/jama.2020.8556)
- Schofield, B., Gregory, C., Gal, M., Gillespie, D., Naik, G., Hay, A. and Francis, N. 2020. The feasibility of measuring calprotectin from a throat swab as a marker of infections caused by group A streptococcus: a case–control feasibility study. BJGP Open 4(2), article number: 20X101006. (10.3399/bjgpopen20X101006)
- Lim, R. et al. 2020. Theory-based electronic learning intervention to support appropriate antibiotic prescribing by nurse and pharmacist independent prescribers: an acceptability and feasibility experimental study using mixed methods. BMJ Open 10(6), article number: e036181. (10.1136/bmjopen-2019-036181)
- Francis, N. A. et al. 2020. C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT. Health Technology Assessment 24, article number: 15. (10.3310/hta24150)
- Read, S. et al. 2020. Chronic conditions and behavioural change approaches to medication adherence: rethinking clinical guidance and recommendations. Patient Preference and Adherence 14, pp. 581-586., article number: 52446. (10.2147/PPA.S239916)
2019
- Courtenay, M. et al. 2019. A theory-based electronic learning intervention to support appropriate antibiotic prescribing by nurses and pharmacists: intervention development and feasibility study protocol. BMJ Open 9(8), article number: e028326. (10.1136/bmjopen-2018-028326)
- Butler, C. C. et al. 2019. C-reactive protein testing to guide antibiotic prescribing for COPD exacerbations. New England Journal of Medicine 381, pp. 111-120. (10.1056/NEJMoa1803185)
- Drew, C. J. G. et al. 2019. A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial). Pilot and Feasibility Studies 5(1), article number: 87. (10.1186/s40814-019-0474-x)
- Owen-Jones, E. et al. 2019. Protocol for a double-blind placebo-controlled trial to evaluate the efficacy of probiotics in reducing antibiotics for infection in care home residents: the Probiotics to Reduce Infections iN CarE home reSidentS (PRINCESS) trial. BMJ Open 9(6), article number: e027513. (10.1136/bmjopen-2018-027513)
- Randell, E. et al. 2019. Sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children: study protocol for a pragmatic randomised controlled trial.. Trials 20, article number: 113. (10.1186/s13063-019-3205-y)
- Stuart, B. et al. 2019. Delayed antibiotic prescribing for respiratory tract infections: protocol of an individual patient data meta-analysis. BMJ Open 9(1), pp. -., article number: e026925. (10.1136/bmjopen-2018-026925)
- Nollett, C. et al. 2019. Depressive symptoms in people with a vision impairment: A cross-sectional study to identify who is most at risk. BMJ Open 9(1), article number: e026163. (10.1136/bmjopen-2018-026163)
- Flynn, S., Hastings, R., McNamara, R., Gillespie, D., Randell, E., Richards, L. and Taylor, Z. 2019. Who’s challenging who?: A co-produced approach for training staff in learning disability services about challenging behaviour. Tizard Learning Disability Review 24(4), pp. 192-199. (10.1108/TLDR-03-2019-0013)
2018
- Flynn, S., Hastings, R., Gillespie, D., McNamara, R. and Randell, E. 2018. Is the amount of exposure to aggressive challenging behaviour related to staff work-related 14 well-being in intellectual disability services? Evidence from a clustered research design.. Research in Developmental Disabilities 81, pp. 155-161. (10.1016/j.ridd.2018.04.006)
- Hastings, R. et al. 2018. Who’s challenging who training for staff empathy towards adults with challenging behaviour: cluster randomised controlled trial. Journal of Intellectual Disability Research 62(9), pp. 798-813. (10.1111/jir.12536)
- Gillespie, D., Francis, N. A., Carrol, E. D., Thomas-Jones, E., Butler, C. C. and Hood, K. 2018. Use of co-primary outcomes for trials of antimicrobial stewardship interventions. Lancet Infectious Diseases 18(6), pp. 595-597. (10.1016/S1473-3099(18)30289-5)
- Butler, C. C. et al. 2018. Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness. British Journal of General Practice 68(669), pp. e268-e278. (10.3399/bjgp18X695285)
2017
- Segrott, J. et al. 2017. An application of Extended Normalisation Process Theory in a randomised controlled trial of a complex social intervention: process evaluation of the Strengthening Families Programme (10-14) in Wales, UK. SSM - Population Health 3, pp. 255-265. (10.1016/j.ssmph.2017.01.002)
- Butler, C. C. et al. 2017. Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study. British Journal of General Practice 67(665), pp. e830-e841. (10.3399/bjgp17X693641)
- Courtenay, M., Gillespie, D. and Lim, R. 2017. Patterns of dispensed non-medical prescriber prescriptions for antibiotics in primary care across England: a retrospective analysis. Journal of Antimicrobial Chemotherapy 72(10) (10.1093/jac/dkx230)
- Bates, J. et al. 2017. General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial. Trials 18, article number: 422. (10.1186/s13063-017-2144-8)
- McNamara, R. et al. 2017. A pilot randomised controlled trial of community-led ANtipsychotic Drug REduction for Adults with Learning Disabilities. Project Report. [Online]. Health Technology Assessment. Available at: https://doi.org/10.3310/hta21470
- Gillespie, D. et al. 2017. Determinants of initiation, implementation, and discontinuation of amoxicillin by adults with acute cough in primary care. Patient Preference and Adherence 2017(11), pp. 561-569. (10.2147/PPA.S119256)
- Gillespie, D. et al. 2017. The use of randomisation-based efficacy estimators in non-inferiority trials. Trials 18(1), article number: 117. (10.1186/s13063-017-1837-3)
2015
- Gillespie, D. et al. 2015. The use of randomisation-based efficacy estimators in non-inferiority trials [Poster Presentation]. Trials 16(Suppl), pp. P129. (10.1186/1745-6215-16-S2-P129)
- Gillespie, D. et al. 2015. Antibiotic prescribing and associated diarrhoea: a prospective cohort study of care home residents. Age and Ageing 44(5), pp. 853-860. (10.1093/ageing/afv072)
- Simpson, S. A. et al. 2015. A feasibility randomised controlled trial of a motivational interviewing-based intervention for weight loss maintenance in adults. Health Technology Assessment 19(50) (10.3310/hta19500)
- Gillespie, D. et al. 2015. Adherence-adjusted estimates of benefits and harms from treatment with amoxicillin for LRTI: secondary analysis of a 12-country randomised placebo- controlled trial using randomisation- based efficacy estimators. BMJ Open 5, article number: e006160. (10.1136/bmjopen-2014-006160)
2014
- Hood, K. et al. 2014. Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes. Health Technology Assessment 18(63) (10.3310/hta18630)
- Gillespie, D., Hood, K., Farewell, D., Stenson, R., Probert, C. and Hawthorne, A. B. 2014. Electronic monitoring of medication adherence in a 1-year clinical study of 2 dosing regimens of mesalazine for adults in remission with ulcerative colitis. Inflammatory Bowel Diseases 20(1), pp. 82-91. (10.1097/01.MIB.0000437500.60546.2a)
- Segrott, J. et al. 2014. Preventing substance misuse: study protocol for a randomised controlled trial of the Strengthening Families Programme 10-14 UK (SFP 10-14 UK). BMC Public Health 14(1), article number: 49. (10.1186/1471-2458-14-49)
- Segrott, J. et al. 2014. Fidelity of implementation of the Strengthening Families Programme 10-14 UK in Wales UK: a mixed-method process evaluation within a randomised controlled trial. Presented at: 7th European Public Health Conference, Glasgow, Scotland,, 19-22 November 2014.
- Moore, L. A. R. et al. 2014. Strengthening Families Programme (10-14UK) substance misuse prevention programme: findings from NPRI randomised trial of a proportionate universalism adaptation of an intervention for families with children aged 10-14. Presented at: 10th UKSBM Annual Scientific Meeting, Nottingham, 3-4 December 2014. pp. 1642-1647.
2013
- Rose, J. et al. 2013. Different factors influence self-reports and third-party reports of anger by adults with intellectual disabilities. Journal of Applied Research in Intellectual Disabilities 26(5), pp. 410-419. (10.1111/jar.12037)
- Mustafa, M., Carson-Stevens, A., Gillespie, D. and Edwards, A. G. 2013. Psychological interventions for women with metastatic breast cancer. Cochrane Library 2013(6), article number: CD004253. (10.1002/14651858.CD004253.pub4)
- Willner, P. et al. 2013. Group-based cognitive-behavioural anger management for people with mild to moderate intellectual disabilities: cluster randomised controlled trial. The British Journal of Psychiatry 203, pp. 288-296. (10.1192/bjp.bp.112.124529)
2012
- Hawthorne, A. B. et al. 2012. One-year investigator-blind randomized multicenter trial comparing asacol 2.4 g once daily with 800 mg three times daily for maintenance of remission in ulcerative colitis. Inflammatory Bowel Diseases 18(10), pp. 1885-1893. (10.1002/ibd.21938)
- Francis, N. A. et al. 2012. Delayed antibiotic prescribing and associated antibiotic consumption in adults with acute cough. British Journal of General Practice (BJGP) 62(602), pp. e639-e646. (10.3399/bjgp12X654614)
- Allen, D. A. et al. 2012. Continuity of care in the transition from child to adult diabetes services: A realistic evaluation study. Journal of Health Services Research and Policy 17(3), pp. 140-148. (10.1258/jhsrp.2011.011044)
- Francis, N. A. et al. 2012. Antibiotics for acute cough: an international observational study of patient adherence in primary care. British Journal of General Practice (BJGP) 62(599), pp. e429-e437. (10.3399/bjgp12X649124)
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- Hood, K. et al. 2012. Mode of data elicitation, acquisition and response to surveys: a systematic review. Health Technology Assessment 16(27) (10.3310/hta16270)
2011
- Willner, P. et al. 2011. Anger management for people with mild to moderate learning disabilities: study protocol for a multi-centre cluster randomized controlled trial of a manualized intervention delivered by day-service staff. Trials 12, pp. 36-47. (10.1186/1745-6215-12-36)
2010
- Allen, D. A. et al. 2010. The transition from paediatric to adult diabetes services: what works, for whom and in what circumstances? [Final report. NIHR Service Delivery and Organisation programme]. Project Report. [Online]. HMSO. Available at: http://www.netscc.ac.uk/hsdr/files/project/SDO_FR_08-1504-107_V01.pdf
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2009
- Butler, C. C. et al. 2009. Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries. BMJ 338, article number: b2242. (10.1136/bmj.b2242)
Articles
- Khammas, Z., Gillespie, D., Williams, A. D. N., Nicholls, J. and Wood, F. 2024. HIV Pre‐Exposure Prophylaxis (PrEP) users' experiences of PrEP access, sexual behaviour, and well‐being during the COVID‐19 pandemic: A Welsh qualitative study. Health Expectations 27(5), article number: e70064. (10.1111/hex.70064)
- Johansen, E., Nielsen, H., Gillespie, D., Aabenhus, R. and Hansen, M. P. 2024. The optimal antibiotic treatment duration for community-acquired pneumonia in adults diagnosed in general practice in Denmark (CAP-D): an open-label, pragmatic, randomised controlled trial. Trials 25, article number: 627. (10.1186/s13063-024-08477-z)
- Langdon, P. E. et al. 2024. Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities: The BEAMS ‐ ID feasibility study. Journal of Applied Research in Intellectual Disabilities 37(5), article number: e13282. (10.1111/jar.13282)
- Lowe, J. et al. 2024. Azithromycin therapy for prevention of chronic lung disease of prematurity (AZTEC): a multicentre, double-blind, randomised, placebo-controlled trial. The Lancet Respiratory Medicine 12(8), pp. 608-618. (10.1016/S2213-2600(24)00079-1)
- Lowe, J., Berrington, J., Gillespie, D., Turner, M. and Kotecha, S. 2024. Challenges of modulating the risk of bronchopulmonary dysplasia in clinical trials – Authors' reply. The Lancet Respiratory Medicine 12(8), article number: E44. (10.1016/S2213-2600(24)00173-5)
- Underwood, J., Griffiths, R., Gillespie, D., Akbari, A. and Ahmed, H. 2024. All-cause and infection-attributable mortality amongst adults with bloodstream infection—a population-based study. Open Forum Infectious Diseases 11(5), article number: ofae126. (10.1093/ofid/ofae126)
- Gillooly, A. et al. 2024. Behavioural activation for depressive symptoms in adults with severe to profound intellectual disabilities: Modelling and initial feasibility study. Journal of Applied Research in Intellectual Disabilities 37(2), article number: e13197. (10.1111/jar.13197)
- Randell, E. et al. 2024. Exploring critical intervention features and trial processes in the evaluation of sensory integration therapy for autistic children. BMC Trials 25(1), article number: 131. (10.1186/s13063-024-07957-6)
- Langdon, P. E. et al. 2024. Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities: the BEAMS-ID feasibility study. Health Technology Assessment 28(72), pp. 1-147. (10.3310/mwtq5721)
- Taylor, E. L. et al. 2023. Mapping and identifying service models for community-based services for children with intellectual disabilities and behaviours that challenge in England. BMC Health Services Research 23(1), article number: 1354. (10.1186/s12913-023-10388-9)
- Gillespie, D. et al. 2023. Gut microbiology of UK care home residents: cross-sectional analysis from a randomised controlled trial. Clinical Microbiology and Infection 29(11), pp. 1437-1442. (10.1016/j.cmi.2023.08.001)
- Boateng, I. et al. 2023. Using microbiological data to improve the use of antibiotics for respiratory tract infections: A protocol for an individual patient data meta-analysis. PLoS ONE 18(11), article number: e0294845. (10.1371/journal.pone.0294845)
- Courtenay, M., Gillespie, D. and Lim, R. 2023. Patterns of GP and nurse independent prescriber prescriptions for antibiotics dispensed in the community in England: a retrospective analysis. Journal of Antimicrobial Chemotherapy 78(10), pp. 2544-2553., article number: dkad267. (10.1093/jac/dkad267)
- Roberts-Tyler, E. J., Roberts, S. E., Watkins, R., Hughes, J. C., Hastings, R. P. and Gillespie, D. 2023. Effects of implementation support on children?s reading outcomes following an online early reading programme: a cluster-randomised controlled trial. British Journal of Educational Technology 54(5), pp. 1373-1396. (10.1111/bjet.13312)
- Richardson, L. et al. 2023. Standing up for Myself (STORM): Adapting and piloting a web-delivered psychosocial group intervention for people with intellectual disabilities. Research in Developmental Disabilities 137, article number: 104496. (10.1016/j.ridd.2023.104496)
- Gillespie, D. et al. 2023. Between- and within-individual sociodemographic and psychological determinants of PrEP adherence among men who have sex with men prescribed a daily PrEP regimen in Wales. AIDS and Behavior 27, pp. 1564-1572. (10.1007/s10461-022-03890-4)
- Lau, T. et al. 2023. Perspectives of statistician, microbiologist, and clinician stakeholders on the use of microbiological outcomes in randomised trials of antimicrobial stewardship interventions. Antibiotics, article number: 885. (10.3390/antibiotics12050885)
- Pickles, T., Horton, M., Christensen, K. B., Phillips, R., Gillespie, D., Mo, N. and Choy, E. 2023. P035 Patient-reported outcome measures for rheumatoid arthritis disease activity: using Rasch measurement theory to achieve more meaningful measurement. Rheumatology 62(Supp 2) (10.1093/rheumatology/kead104.076)
- Hounkpatin, H. et al. 2023. Post-consultation acute respiratory tract infection recovery: a latent class informed analysis of individual patient data from randomised controlled trials and observational studies. British Journal of General Practice 73(728), pp. e196-e203. (10.3399/BJGP.2022.0229)
- Gillespie, D. et al. 2023. Psychometric Properties of an Adapted Stigma Scale and Experiences of Stigma Associated with HIV Pre-exposure Prophylaxis Use Among Men Who have Sex with Men: A Mixed Methods Study. AIDS and Behavior (10.1007/s10461-022-03967-0)
- Evans, A., Mantzourani, E., Gillespie, D., Hughes, L., Sharpe, G. and Yip, N. 2022. Location, location, location: does providing public health services from community pharmacies contribute to tackling health inequalities?. Journal of Public Health, article number: fdac148. (10.1093/pubmed/fdac148)
- Phillips, R. et al. 2022. Perceived threat of COVID-19, attitudes towards vaccination, and vaccine hesitancy: A prospective longitudinal study in the UK. British Journal of Health Psychology 27(4), pp. 1354-1381. (10.1111/bjhp.12606)
- Williams, A. D. N., Wood, F., Gillespie, D., Couzens, Z., Hughes, K. and Hood, K. 2022. The relationship between HIV pre-exposure prophylaxis, sexually transmitted infections, and antimicrobial resistance: a qualitative interview study of men who have sex with men. BMC Public Health 22(1), article number: 2222. (10.1186/s12889-022-14645-0)
- Carvalho, M. J. et al. 2022. Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries. Nature Microbiology 7, pp. 1337-1347. (10.1038/s41564-022-01184-y)
- Reeve, N. F. et al. 2022. Myocardial infarction and stroke subsequent to urinary tract infection (MISSOURI): protocol for a self-controlled case series using linked electronic health records. BMJ Open 12, article number: e064586. (10.1136/bmjopen-2022-064586)
- Kotecha, S. J., Course, C. W., Jones, K. E., Watkins, W. J., Berrington, J., Gillespie, D. and Kotecha, S. 2022. Follow-up study of infants recruited to the randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants: study protocol for the AZTEC-FU study. Trials 23, article number: 796. (10.1186/s13063-022-06730-x)
- Milton, R. et al. 2022. Incidence and sociodemographic, living environment and maternal health associations with stillbirth in a tertiary healthcare setting in Kano, Northern Nigeria. Short title: Incidence and factors associated with stillbirth in Kano, Nigeria. BMC Pregnancy and Childbirth 22, article number: 692. (10.1186/s12884-022-04971-x)
- Gillespie, D. et al. 2022. PrEP use, sexual behaviour, and PrEP adherence among men who have sex with men living in Wales prior to and during the COVID-19 pandemic. AIDS and Behavior 26, pp. 2746-2757. (10.1007/s10461-022-03618-4)
- Lau, T. M. M., Lowe, J., Pickles, T., Hood, K., Kotecha, S. and Gillespie, D. 2022. AZTEC—azithromycin therapy for prevention of chronic lung disease of prematurity: a statistical analysis plan for clinical outcomes. Trials 23(1), article number: 704. (10.1186/s13063-022-06604-2)
- Milosevic, S. et al. 2022. Understanding the support experiences of families of children with autism and sensory processing difficulties: A qualitative study.. Health Expectations 25(3), pp. 1118-1130. (10.1111/hex.13465)
- Randell, E. et al. 2022. Sensory integration therapy for children with autism and sensory processing difficulties: the SenITA RCT. Health Technology Assessment 26(29) (10.3310/TQGE0020)
- Neill, R., Gillespie, D. and Ahmed, H. 2022. Variation in antibiotic treatment failure outcome definitions in randomised trials and observational studies of antibiotic pre-scribing strategies: A systematic review and narrative synthesis. Antibiotics 11(5), article number: 627. (10.3390/antibiotics11050627)
- Hoult, G., Gillespie, D., Wilkinson, T. M. A., Thomas, M. and Francis, N. A. 2022. Biomarkers to guide the use of antibiotics for acute exacerbations of COPD (AECOPD): a systematic review and meta-analysis. BMC Pulmonary Medicine 22(1), article number: 194. (10.1186/s12890-022-01958-4)
- Gillespie, D. et al. 2022. Experiences of men who have sex with men when initiating, implementing, and persisting with HIV pre-exposure prophylaxis. Health Expectations 25(4), pp. 1332-1341. (10.1111/hex.13446)
- Pickles, T. et al. 2022. Patient reported outcome measures for rheumatoid arthritis disease activity: a systematic review following COSMIN guidelines. RMD Open 8(1), article number: e002093. (10.1136/rmdopen-2021-002093)
- Lau, T. M. M., Daniel, R., Hughes, K., Wootton, M., Hood, K. and Gillespie, D. 2022. A systematic review investigating the use of microbiology outcome measures in randomized controlled trials evaluating antimicrobial stewardship interventions published between 2011 and 2021. JAC-Antimicrobial Resistance 4(1), article number: dlac013. (10.1093/jacamr/dlac013)
- Williams, A., Gillespie, D., Couzens, Z., Wood, F., Hughes, K. and Hood, K. 2022. Changing sexual behaviours amongst MSM during the COVID-19 restrictions in Wales: a mixed methods study. BMC Public Health 22(1), article number: 396. (10.1186/s12889-022-12821-w)
- Segrott, J. et al. 2022. Effectiveness of the strengthening families programme in the UK at preventing substance misuse in 10-14 year-olds: a pragmatic randomised controlled trial. BMJ Open 12(2), article number: e049647. (10.1136/bmjopen-2021-049647)
- Gillespie, D. et al. 2022. Associations with post-consultation health-status in primary care managed acute exacerbation of COPD. International Journal of Chronic Obstructive Pulmonary Disease 2022(17), pp. 383-394. (10.2147/COPD.S340710)
- Moody, G. et al. 2022. The READ-IT study protocol for a feasibility randomised controlled trial of using a support worker/family carer mediated online reading programme to teach early reading skills to adults with intellectual disabilities. Pilot and Feasibility Studies 8(1), article number: 13. (10.1186/s40814-022-00972-x)
- Milton, R. et al. 2022. Determinants of stillbirth from two observational studies investigating deliveries in Kano, Nigeria. Frontiers in Global Women's Health 2, article number: 788157. (10.3389/fgwh.2021.788157)
- Coulman, E. et al. 2021. Early positive approaches to support (E-PAtS) for families of young children with intellectual disability: a feasibility randomised controlled trial. Frontiers in Psychiatry 12, article number: 729129. (10.3389/fpsyt.2021.729129)
- Ahmed, H., Gillespie, D. and Thomas-Jones, E. 2021. Effect of 7 vs 14 days of antibiotics among afebrile men with urinary tract infection. Journal of the American Medical Association 326(20), article number: 2080. (10.1001/jama.2021.16738)
- Phillips, R. et al. 2021. Cohort profile: The UK COVID-19 Public Experiences (COPE) prospective longitudinal mixed-methods study of health and well-being during the SARSCoV2 coronavirus pandemic. PLoS ONE 16(10), article number: e0258484. (10.1371/journal.pone.0258484)
- Read, S. et al. 2021. Normalisation process theory and the implementation of a new glaucoma clinical pathway in hospital eye services: perspectives of doctors, nurses and optometrists. PLoS ONE 16(8), article number: e0255564. (10.1371/journal.pone.0255564)
- Gillespie, D. et al. 2021. Early impact of COVID-19 social distancing measures on reported sexual behaviour of HIV pre-exposure prophylaxis users in Wales. Sexually Transmitted Infections 97, pp. 85-87. (10.1136/sextrans-2020-054598)
- Gillespie, D. et al. 2021. Associations with antibiotic prescribing for acute exacerbation of COPD in primary care: secondary analysis of a randomised controlled trial. British Journal of General Practice 71(705), pp. e266-e272. (10.3399/BJGP.2020.0823)
- Sands, K. et al. 2021. Characterization of antimicrobial resistant Gram-negative bacteria that cause neonatal sepsis in seven low and middle-income countries. Nature Microbiology 6, pp. 512–523. (10.1038/s41564-021-00870-7)
- Butler, C. C. et al. 2021. Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT. Efficacy and Mechanism Evaluation 8(7) (10.3310/eme08070)
- Stuart, B. et al. 2021. Delayed antibiotic prescribing for respiratory tract infections: an individual patient data meta-analysis. BMJ 372, article number: n808. (10.1136/bmj.n808)
- Castro-Herrera, V. M. et al. 2021. Combination of the probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis, BB-12 has limited effect on biomarkers of immunity and inflammation in older people resident in care homes: results from the Probiotics to Reduce Infections iN CarE home reSidentS Randomized, Controlled Trial. Frontiers in Immunology 12, article number: 643321. (10.3389/fimmu.2021.643321)
- Felloner, J. et al. 2021. A multi-stakeholder approach to the co-production of the research agenda for medicines optimisation. BMC Health Services Research 21, article number: 64. (10.1186/s12913-021-06056-5)
- M.Castro-Herrera, V. et al. 2021. Relationship between age, frailty, length of care home residence and biomarkers of immunity and inflammation in older care residents in the UK. Frontiers in Aging 2, article number: 599084. (10.3389/fragi.2021.599084)
- Waterman, H. et al. 2020. Acceptability, adherence and economic analyses of a new clinical pathway for the identification of non-responders to glaucoma eye drops: a prospective observational study. British Journal of Ophthalmology 104(12), pp. 1704-1709. (10.1136/bjophthalmol-2019-315436)
- Francis, N. A. et al. 2020. Clinical features and c-reactive protein as predictors of bacterial exacerbations of COPD. International Journal of Chronic Obstructive Pulmonary Disease 2020, pp. 3147-3158. (10.2147/COPD.S265674)
- Lowe, J. et al. 2020. Study protocol: azithromycin therapy for chronic lung disease of prematurity (AZTEC) - a randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants. BMJ Open 10(10), article number: e041528. (10.1136/bmjopen-2020-041528)
- Alghamdi, S. et al. 2020. Prescribing trends over time by non-medical independent prescribers (NMIPs) in primary care settings across Wales (2011-2018): a secondary database analysis. BMJ Open 10, article number: e036379. (10.1136/bmjopen-2019-036379)
- Coulman, E. et al. 2020. The Early Positive Approaches to Support (E-PAtS) study: study protocol for a feasibility cluster randomised controlled trial of a group programme (E-PAtS) for family caregivers of young children with intellectual disability. Pilot and Feasibility Studies 6(1), article number: 147. (10.1186/s40814-020-00689-9)
- Phillips, R. et al. 2020. C-Reactive Protein-guided antibiotic prescribing for COPD exacerbations: a qualitative evaluation. British Journal of General Practice 70(696), pp. e505-e523. (10.3399/bjgp20X709865)
- Butler, C. C. et al. 2020. Effect of probiotic use on antibiotic administration among care home residents: a randomized clinical trial. Journal of the American Medical Association 324(1), pp. 47 - 56. (10.1001/jama.2020.8556)
- Schofield, B., Gregory, C., Gal, M., Gillespie, D., Naik, G., Hay, A. and Francis, N. 2020. The feasibility of measuring calprotectin from a throat swab as a marker of infections caused by group A streptococcus: a case–control feasibility study. BJGP Open 4(2), article number: 20X101006. (10.3399/bjgpopen20X101006)
- Lim, R. et al. 2020. Theory-based electronic learning intervention to support appropriate antibiotic prescribing by nurse and pharmacist independent prescribers: an acceptability and feasibility experimental study using mixed methods. BMJ Open 10(6), article number: e036181. (10.1136/bmjopen-2019-036181)
- Francis, N. A. et al. 2020. C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT. Health Technology Assessment 24, article number: 15. (10.3310/hta24150)
- Read, S. et al. 2020. Chronic conditions and behavioural change approaches to medication adherence: rethinking clinical guidance and recommendations. Patient Preference and Adherence 14, pp. 581-586., article number: 52446. (10.2147/PPA.S239916)
- Courtenay, M. et al. 2019. A theory-based electronic learning intervention to support appropriate antibiotic prescribing by nurses and pharmacists: intervention development and feasibility study protocol. BMJ Open 9(8), article number: e028326. (10.1136/bmjopen-2018-028326)
- Butler, C. C. et al. 2019. C-reactive protein testing to guide antibiotic prescribing for COPD exacerbations. New England Journal of Medicine 381, pp. 111-120. (10.1056/NEJMoa1803185)
- Drew, C. J. G. et al. 2019. A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial). Pilot and Feasibility Studies 5(1), article number: 87. (10.1186/s40814-019-0474-x)
- Owen-Jones, E. et al. 2019. Protocol for a double-blind placebo-controlled trial to evaluate the efficacy of probiotics in reducing antibiotics for infection in care home residents: the Probiotics to Reduce Infections iN CarE home reSidentS (PRINCESS) trial. BMJ Open 9(6), article number: e027513. (10.1136/bmjopen-2018-027513)
- Randell, E. et al. 2019. Sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children: study protocol for a pragmatic randomised controlled trial.. Trials 20, article number: 113. (10.1186/s13063-019-3205-y)
- Stuart, B. et al. 2019. Delayed antibiotic prescribing for respiratory tract infections: protocol of an individual patient data meta-analysis. BMJ Open 9(1), pp. -., article number: e026925. (10.1136/bmjopen-2018-026925)
- Nollett, C. et al. 2019. Depressive symptoms in people with a vision impairment: A cross-sectional study to identify who is most at risk. BMJ Open 9(1), article number: e026163. (10.1136/bmjopen-2018-026163)
- Flynn, S., Hastings, R., McNamara, R., Gillespie, D., Randell, E., Richards, L. and Taylor, Z. 2019. Who’s challenging who?: A co-produced approach for training staff in learning disability services about challenging behaviour. Tizard Learning Disability Review 24(4), pp. 192-199. (10.1108/TLDR-03-2019-0013)
- Flynn, S., Hastings, R., Gillespie, D., McNamara, R. and Randell, E. 2018. Is the amount of exposure to aggressive challenging behaviour related to staff work-related 14 well-being in intellectual disability services? Evidence from a clustered research design.. Research in Developmental Disabilities 81, pp. 155-161. (10.1016/j.ridd.2018.04.006)
- Hastings, R. et al. 2018. Who’s challenging who training for staff empathy towards adults with challenging behaviour: cluster randomised controlled trial. Journal of Intellectual Disability Research 62(9), pp. 798-813. (10.1111/jir.12536)
- Gillespie, D., Francis, N. A., Carrol, E. D., Thomas-Jones, E., Butler, C. C. and Hood, K. 2018. Use of co-primary outcomes for trials of antimicrobial stewardship interventions. Lancet Infectious Diseases 18(6), pp. 595-597. (10.1016/S1473-3099(18)30289-5)
- Butler, C. C. et al. 2018. Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness. British Journal of General Practice 68(669), pp. e268-e278. (10.3399/bjgp18X695285)
- Segrott, J. et al. 2017. An application of Extended Normalisation Process Theory in a randomised controlled trial of a complex social intervention: process evaluation of the Strengthening Families Programme (10-14) in Wales, UK. SSM - Population Health 3, pp. 255-265. (10.1016/j.ssmph.2017.01.002)
- Butler, C. C. et al. 2017. Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study. British Journal of General Practice 67(665), pp. e830-e841. (10.3399/bjgp17X693641)
- Courtenay, M., Gillespie, D. and Lim, R. 2017. Patterns of dispensed non-medical prescriber prescriptions for antibiotics in primary care across England: a retrospective analysis. Journal of Antimicrobial Chemotherapy 72(10) (10.1093/jac/dkx230)
- Bates, J. et al. 2017. General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial. Trials 18, article number: 422. (10.1186/s13063-017-2144-8)
- Gillespie, D. et al. 2017. Determinants of initiation, implementation, and discontinuation of amoxicillin by adults with acute cough in primary care. Patient Preference and Adherence 2017(11), pp. 561-569. (10.2147/PPA.S119256)
- Gillespie, D. et al. 2017. The use of randomisation-based efficacy estimators in non-inferiority trials. Trials 18(1), article number: 117. (10.1186/s13063-017-1837-3)
- Gillespie, D. et al. 2015. The use of randomisation-based efficacy estimators in non-inferiority trials [Poster Presentation]. Trials 16(Suppl), pp. P129. (10.1186/1745-6215-16-S2-P129)
- Gillespie, D. et al. 2015. Antibiotic prescribing and associated diarrhoea: a prospective cohort study of care home residents. Age and Ageing 44(5), pp. 853-860. (10.1093/ageing/afv072)
- Simpson, S. A. et al. 2015. A feasibility randomised controlled trial of a motivational interviewing-based intervention for weight loss maintenance in adults. Health Technology Assessment 19(50) (10.3310/hta19500)
- Gillespie, D. et al. 2015. Adherence-adjusted estimates of benefits and harms from treatment with amoxicillin for LRTI: secondary analysis of a 12-country randomised placebo- controlled trial using randomisation- based efficacy estimators. BMJ Open 5, article number: e006160. (10.1136/bmjopen-2014-006160)
- Hood, K. et al. 2014. Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes. Health Technology Assessment 18(63) (10.3310/hta18630)
- Gillespie, D., Hood, K., Farewell, D., Stenson, R., Probert, C. and Hawthorne, A. B. 2014. Electronic monitoring of medication adherence in a 1-year clinical study of 2 dosing regimens of mesalazine for adults in remission with ulcerative colitis. Inflammatory Bowel Diseases 20(1), pp. 82-91. (10.1097/01.MIB.0000437500.60546.2a)
- Segrott, J. et al. 2014. Preventing substance misuse: study protocol for a randomised controlled trial of the Strengthening Families Programme 10-14 UK (SFP 10-14 UK). BMC Public Health 14(1), article number: 49. (10.1186/1471-2458-14-49)
- Rose, J. et al. 2013. Different factors influence self-reports and third-party reports of anger by adults with intellectual disabilities. Journal of Applied Research in Intellectual Disabilities 26(5), pp. 410-419. (10.1111/jar.12037)
- Mustafa, M., Carson-Stevens, A., Gillespie, D. and Edwards, A. G. 2013. Psychological interventions for women with metastatic breast cancer. Cochrane Library 2013(6), article number: CD004253. (10.1002/14651858.CD004253.pub4)
- Willner, P. et al. 2013. Group-based cognitive-behavioural anger management for people with mild to moderate intellectual disabilities: cluster randomised controlled trial. The British Journal of Psychiatry 203, pp. 288-296. (10.1192/bjp.bp.112.124529)
- Hawthorne, A. B. et al. 2012. One-year investigator-blind randomized multicenter trial comparing asacol 2.4 g once daily with 800 mg three times daily for maintenance of remission in ulcerative colitis. Inflammatory Bowel Diseases 18(10), pp. 1885-1893. (10.1002/ibd.21938)
- Francis, N. A. et al. 2012. Delayed antibiotic prescribing and associated antibiotic consumption in adults with acute cough. British Journal of General Practice (BJGP) 62(602), pp. e639-e646. (10.3399/bjgp12X654614)
- Allen, D. A. et al. 2012. Continuity of care in the transition from child to adult diabetes services: A realistic evaluation study. Journal of Health Services Research and Policy 17(3), pp. 140-148. (10.1258/jhsrp.2011.011044)
- Francis, N. A. et al. 2012. Antibiotics for acute cough: an international observational study of patient adherence in primary care. British Journal of General Practice (BJGP) 62(599), pp. e429-e437. (10.3399/bjgp12X649124)
- Butler, C. C. et al. 2012. Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomised controlled trial. British Medical Journal (BMJ) 344, article number: d8173. (10.1136/bmj.d8173)
- Hood, K. et al. 2012. Mode of data elicitation, acquisition and response to surveys: a systematic review. Health Technology Assessment 16(27) (10.3310/hta16270)
- Willner, P. et al. 2011. Anger management for people with mild to moderate learning disabilities: study protocol for a multi-centre cluster randomized controlled trial of a manualized intervention delivered by day-service staff. Trials 12, pp. 36-47. (10.1186/1745-6215-12-36)
- Stanton, N. et al. 2010. Are smokers with acute cough in primary care prescribed antibiotics more often, and to what benefit? An observational study in 13 European countries. European Respiratory Journal 35(4), pp. 761-767. (10.1183/09031936.00168409)
- Butler, C. C. et al. 2009. Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries. BMJ 338, article number: b2242. (10.1136/bmj.b2242)
Conferences
- Pickles, T., Horton, M., Christensen, K. B., Phillips, R., Gillespie, D., Mo, N. and Choy, E. 2023. Patient reported outcome measures for rheumatoid arthritis disease activity: using Rasch measurement theory and cognitive interviewing to achieve more meaningful measurement. Presented at: ACR Convergence 2023, San Diego, 10-15 November 2023, Vol. 75. Vol. Supp 9.
- Pickles, T. et al. 2022. P089 Patient-reported outcome measures for rheumatoid arthritis disease activity: a systematic review following COSMIN guidelines. Presented at: British Society for Rheumatology Annual Conference 2022, Glasgow, Scotland, 25-27 April 2022Rheumatology Supplement 1, Vol. 61. pp. keac133.088., (10.1093/rheumatology/keac133.088)
- Segrott, J. et al. 2014. Fidelity of implementation of the Strengthening Families Programme 10-14 UK in Wales UK: a mixed-method process evaluation within a randomised controlled trial. Presented at: 7th European Public Health Conference, Glasgow, Scotland,, 19-22 November 2014.
- Moore, L. A. R. et al. 2014. Strengthening Families Programme (10-14UK) substance misuse prevention programme: findings from NPRI randomised trial of a proportionate universalism adaptation of an intervention for families with children aged 10-14. Presented at: 10th UKSBM Annual Scientific Meeting, Nottingham, 3-4 December 2014. pp. 1642-1647.
Monographs
- Scior, K. et al. 2024. Digital adaptation of the Standing up for Myself intervention in young people and adults with intellectual disabilities: the STORM feasibility study. Project Report. [Online]. National Institute for Health Research. Available at: https://doi.org/10.3310/NCBU6224
- McNamara, R. et al. 2017. A pilot randomised controlled trial of community-led ANtipsychotic Drug REduction for Adults with Learning Disabilities. Project Report. [Online]. Health Technology Assessment. Available at: https://doi.org/10.3310/hta21470
- Allen, D. A. et al. 2010. The transition from paediatric to adult diabetes services: what works, for whom and in what circumstances? [Final report. NIHR Service Delivery and Organisation programme]. Project Report. [Online]. HMSO. Available at: http://www.netscc.ac.uk/hsdr/files/project/SDO_FR_08-1504-107_V01.pdf
Ymchwil
Rwyf wedi derbyn tua >£37m mewn cyllid grant ar draws 40 o grantiau, gan gynnwys £0.5m fel prif ymchwilydd a >£7m ar gyfer ymchwil ryngwladol.
Grantiau ymchwil (yn fwyaf diweddar yn gyntaf):
2023
- Harding, et al. Paratoadau intraVESical ar gyfer Atal Heintiau TrAct Wrinol Rheolaidd (Astudiaeth VESPA): treial rhagoriaeth ar hap label agored aml-fraich, aml-safle. NIHR HTA. £2.1M.
- Kotecha, et al. Imiwnotherapi mwcosaidd bacteriol ar gyfer atal cenhedlu mewn babanod a aned cyn y tymor (BALLOON Trial). NIHR/MRC EME. £2.7M.
- Edwards, et al. Deunydd hunan-lanhau gyda catalysis ffoto-weithredol: treialon maes yn Nepal. BMGF. £658k.
- Pallmann P a Carrol E, et al. Gwerthuso ar hap platfform o ganlyniadau clinigol gan ddefnyddio technolegau newydd i optimeiddio therapi gwrthficrobaidd (PROTECT). NIHR HTA. £204,987.
2022
- Gore N, et al. Hapdreial rheoledig clwstwr o ddulliau cynnar cadarnhaol o gymorth (e-PAtS) ar gyfer teuluoedd plant ifanc ag anabledd deallusol. NIHR PHR. £1.9m.
- Hayward G, Llewelyn M, et al. Effaith hyd therapi gwrthfiotig ar effeithiolrwydd, diogelwch a dewis ymwrthedd gwrthfiotig mewn menywod sy'n oedolion sydd â heintiau'r llwybr wrinol (UTI): treial rheoledig ar hap. NIHR HTA. £2.4m.
- Channon S, et al. Cwmpasu dichonoldeb datblygu a gwerthuso gwasanaeth cymorth cymheiriaid i bobl sy'n byw gyda HIV yng Nghymru. Iechyd Cyhoeddus Cymru. £32,000.
- Courtenay M, et al. Ymyrraeth dysgu electronig ar sail theori i gefnogi rhagnodi gwrthfiotigau priodol gan ragnodwyr nyrsio a fferyllwyr: astudiaeth arbrofol derbynioldeb a dichonoldeb. Arloesi i bawb. £2,150.
2021
- Jones L, et al. Epidemioleg ac effaith heintiau eilaidd bacteriol ac ymwrthedd gwrthficrobaidd ar Ofal Dwys yn ystod y pandemig SARS-CoV-2. Grant Iechyd HCRW. £175,517
- Ahmed H, et al. Myocardaidd Infarction a strôc Dilynol tO URInary tract infection (MISSOURI). Grant Ymchwil BHF. £220,000.
- Nicholls J, Gillespie D. Optimeiddio modelau darparu gwasanaeth Atal HIV a phroffylacsis cyn amlygiad (PrEP) ar gyfer pob poblogaeth yng Nghaerdydd / Cymru. Gwobr Amser Ymchwil GIG HCRW. £89,000.
- Carreg J, et al. Ffactorau sy'n benodol i gyd-destun sy'n gyrru trosglwyddiad HIV ymhlith dynion sy'n cael rhyw gyda dynion: Modelu rôl ffactorau ymddygiadol, cymdeithasol a chyfreithiol. GW4 Ysgoloriaeth PhD.
- Butler CC, et al. Cyflwyno, rheoli a chanlyniadau haint RSV mewn oedolion mewn gofal sylfaenol: meta-ddadansoddiad cleifion unigol. Janssen Astudiaeth a gychwynnwyd gan ymchwilydd clinigol.
2020
- Langdon P, et al. Ymyriadau ymddygiadol i drin pryder mewn oedolion ag awtistiaeth ac anableddau deallusol cymedrol i ddifrifol (BEAMS – ID). NIHR HTA. £200,000.
- Hastings R, et al. Mapio a Gwerthuso Gwasanaethau ar gyfer Plant ag Anableddau Dysgu ac Ymddygiad sy'n Herio (MELD). NIHR &DR. £1,200,000.
- Holmes et al. Economeg diagnosteg gyflym i leihau presgripsiynu gwrthfiotigau yn GIG Cymru (TRaDe). HCRW HRF. £350,000.
- Gillespie D, et al. Defnyddio dulliau modelu modern ar gyfer dadansoddi ystadegol data microbiolegol mewn treialon clinigol ymyriadau stiwardiaeth gwrthficrobaidd. Ysgol Meddygaeth / Treialon Partneriaeth Ymchwil Methodoleg PhD efrydiaeth.
- Phillips R, et al. Profiadau cyhoeddus COVID-19 yng Nghymru: Astudiaeth hydredol dulliau cymysg o agweddau, credoau ac ymddygiad mewn ymateb i'r pandemig coronafeirws (COPE Cymru). Mae Ser Cymru yn galw am ymchwil COVID-19. £130,000.
- Waterman H, et al. Archwilio rhagdybiaethau, cywirdeb a derbyniad dyfais monitro electronig er mwyn cadw at ddiferion llygaid: yr astudiaeth label EASY. Cymdeithas Ryngwladol Glaucoma. £30,000.
2019
- Hood K, et al. Ymchwil Iechyd a Gofal Cymru. Canolfan Treialon Adnewyddu Seilwaith Ymchwil. £2,500,000.
- Stenfert-Kroese B, et al. Astudiaeth ddichonoldeb ar hap o raglen llythrennedd emosiynol yn yr ysgol (Zippy's Friends) ar gyfer plant ag anableddau deallusol (ZIP-SEND). NIHR PHR. £550,000.
- Scior K, et al. Ymyrraeth grŵp seicogymdeithasol STanding up fOR Myself (STORM) ar gyfer pobl ifanc ac oedolion ag anableddau deallusol: Astudiaeth dichonoldeb. NIHR PHR. £600,000.
- Marsal S, et al. DocTIS - Penderfyniad ar therapïau cyfuniadol gorau posibl mewn IMIDs gan ddefnyddio dulliau system. H2020. € 7,000,000.
- Solomon T, et al. Enceph-IG - Imiwnoglobwlin mewnwythiennol mewn enseffalitis hunanimiwn mewn Oedolion: Treial a reolir gan placebo-ddall dwbl-ddall ar hap. NIHR/MRC EME. £2,400,000.
- Denne L, et al. Addysgu sgiliau darllen cynnar i oedolion ag anableddau deallusol (READ-IT) gan ddefnyddio gweithiwr cymorth/gofalwr teulu rhaglen ddarllen ar-lein gyfryngol – astudiaeth ddichonoldeb. NIHR RfPB. £250,000.
- Pickles T, et al. Adroddodd cleifion fesurau canlyniadau ar gyfer difrifoldeb symptomau Arthritis Rheumatoid. Datblygu prawf addasol cyfrifiadurol o fanc eitem gan ddefnyddio theori mesur Rasch (SOCRATES). Cymrodoriaeth Ddoethurol NIHR. £350,000.
- Gillespie D a Hood K, et al. Deall y berthynas rhwng proffylacsis cyn-amlygiad, heintiau a drosglwyddir yn rhywiol, ac ymwrthedd gwrthficrobaidd yng Nghymru. KESS2 Dwyrain £50,000.
- Kotecha S, et al. AZithromycin ThErapy ar gyfer clefyd cronig yr ysgyfaint (AZTEC): Treial ar hap, a reolir gan placebo o azithromycin ar gyfer atal clefyd cronig yr ysgyfaint cyn-aeddfedrwydd mewn babanod cynamserol. NIHR HTA. £2,100,000.
2018
- Gillespie D, et al. Datblygu ymyriad i wneud y defnydd gorau posibl o broffylacsis cyn-gysylltiad (PrEP) i atal caffaeliad HIV mewn unigolion sydd mewn perygl sy'n byw yng Nghymru (DO-PrEP). Cymrodoriaeth Ymchwil Iechyd a Gofal Iechyd Cymru. £430,000.
- Walsh T, et al. Baich ymwrthedd gwrthfiotig mewn newydd-ddyfodiaid o Gymdeithasau sy'n Datblygu - Dadansoddiadau Epidemiolegol a Genomig o BARNARDS Network. Sefydliad Bill a Melinda Gates £600,000.
2017
- Jahoda A, et al. Ysgogi ymddygiad (BeatIt) ar gyfer iselder mewn oedolion ag anableddau deallusol difrifol. Astudiaeth rheoledig ar hap dichonoldeb o BeatIt yn erbyn triniaeth fel arfer. Cronfa Elusennol Baily Thomas. £100,000.
- Hastings R, et al. Dulliau Cadarnhaol Cynnar o Gymorth (E-PAtS) ar gyfer teuluoedd plant ifanc ag anabledd deallusol: Astudiaeth Ddichonoldeb. NIHR PHR. £500,000.
- Courtenay M et al. Ymyrraeth i ragnodi gofal sylfaenol i gefnogi'r dewis a'r defnydd o wrthfiotigau. ESRC IAA. £20,000.
- Rosser A, et al. Dyluniadau treial ar gyfer darparu therapïau newydd ar gyfer niwro-genhedlaeth (TRIDENT). £220,000.
- Waterman H, et al. Dichonoldeb a Derbynioldeb Llwybr Clinigol newydd ar gyfer Adnabod Ymatebwyr nad ydynt yn Ymatebwyr i Glaucoma Eye Drops (yr astudiaeth TRIAGE). Ymchwil Iechyd a Gofal Cymru RfPPB. £225,000.
2015
- Butler CC, et al. Probiotics i leihau heintiau mewn preswylwyr cartrefi gofal (PRINCESS). NIHR/MRC EME. £1,900,000.
- McNamara R, et al. Treial rheoledig pragmatig ar hap o therapi integreiddio synhwyraidd yn erbyn gofal arferol ar gyfer anawsterau prosesu synhwyraidd mewn anhwylder sbectrwm awtistiaeth mewn plant, a'i effaith ar anawsterau ymddygiad, sgiliau addasol a chymdeithasu (SenITA). NIHR HTA. £1,500,000.
2014
- Butler CC a Francis NA, et al. Ymarferydd Cyffredinol (GP) defnydd o Brawf Pwynt Gofal Protein C-Adweithiol (CRP) (POCT) i helpu i dargedu rhagnodi gwrthfiotigau i gleifion sydd â Gwaethygu Aciwt o Glefyd Rhwystrol Cronig yr Ysgyfaint (AECOPD) sydd fwyaf tebygol o elwa (PACE). NIHR HTA. £1,400,000.
2013
- Kerr M, et al. Lleihau cyffuriau gwrth-seicotig a arweinir gan y gymuned ar gyfer oedolion ag anableddau dysgu: treial a reolir plasebo dwbl-ddall ar hap (ANDREA-LD). £1,500,000.
Addysgu
Addysgu
- Ers 2023, rwyf wedi rhoi darlith gwadd gwadd ar gyfer Modiwl Meistr mewn Treialon Clinigol Iechyd y Cyhoedd Coleg Prifysgol Dulyn o'r enw "Dylunio a dadansoddi hapdreialon ymyriadau stiwardiaeth gwrthfiotigau".
- Ers 2019/2020, rwyf wedi traddodi darlith ar "Hapdreialon strategaethau triniaeth i helpu i wella rhagnodi gwrthfiotigau a chanlyniadau cysylltiedig â haint" ar gyfer Modiwl Amodau Aciwt y BSc Rhyng-gyfrifedig Iechyd Poblogaeth.
- Yn ystod blynyddoedd academaidd 2018/2019 a 2019/2020 cynhaliais sesiynau ar ddatblygu protocolau astudio fel rhan o'r modiwl Dulliau Ymchwil 2 ar gyfer myfyrwyr BSc Rhyng-gyfrifedig Meddygol
- Ym mis Mehefin 2016, fe wnes i gyd-ddatblygu a chyflwyno cwrs tridiau ar ddadansoddi data sylfaenol gan ddefnyddio'r iaith rhaglennu ystadegol R (o'r enw "dysgwr") i staff ym Mhrifysgol Namibia fel rhan o Brosiect Phoenix (http://www.cardiff.ac.uk/phoenix-project)
- Yn flaenorol, rwyf wedi dysgu meintiau grwpiau bach a chanolig ar lefel israddedig ac ôl-raddedig ar bynciau gan gynnwys dulliau ymchwil meintiol, ystadegau, ac arfarniad beirniadol
Arolygiaeth
- Yn flaenorol, rwyf wedi goruchwylio myfyrwyr israddedig ac ôl-raddedig yn yr Ysgol Meddygaeth, Ysgol Fferylliaeth, a'r Ysgol Mathemateg, a'r Ysgol Seicoleg (ym Mhrifysgol Caerfaddon) ar bynciau megis agweddau methodolegol ar werthuso ymyriadau stiwardiaeth gwrthficrobaidd, defnyddio meddyginiaeth a chadw meddyginiaeth, a HIV-stigma.
Rwyf wedi goruchwylio'r myfyrwyr PhD canlynol i'w cwblhau:
Adam Williams (goruchwyliwr arweiniol): Deall y berthynas rhwng PrEP, STIs, ac AMR yng Nghymru
Timothy Pickles (cyd-oruchwyliwr): Mesurau canlyniadau a adroddir gan gleifion ar gyfer difrifoldeb symptom arthritis gwynegol: datblygu prawf addasol cyfrifiadurol o fanc eitem gan ddefnyddio theori mesur Rasch
Ar hyn o bryd rwy'n goruchwylio'r myfyrwyr PhD cofrestredig canlynol:
Mandy Lau (goruchwyliwr cyd-arweiniol): Defnyddio dulliau modelu modern ar gyfer dadansoddi ystadegol data microbiolegol mewn treialon clinigol ymyriadau stiwardiaeth gwrthficrobaidd (https://www.cardiff.ac.uk/people/view/362467-lau-mandy)
Saher Aijaz Khan (cyd-oruchwyliwr, dan arweiniad Prifysgol Bryste): Ffactorau sy'n benodol i gyd-destun sy'n gyrru trosglwyddiad HIV ymhlith dynion sy'n cael rhyw gyda dynion: Modelu rôl ffactorau ymddygiadol, cymdeithasol a chyfreithiol (https://gw4biomed.ac.uk/cohort-6/)
Eskild Johansen (cyd-oruchwyliwr, dan arweiniad Prifysgol Aalborg): Y cyfnod triniaeth gwrthfiotig gorau posibl ar gyfer niwmonia a gaffaelir yn y gymuned mewn oedolion a ddiagnosiwyd mewn practis cyffredinol yn Nenmarc: treial rheoledig ar hap label agored, pragmatig, ar hap (https://vbn.aau.dk/en/persons/142036)
Bywgraffiad
Addysg a chymwysterau:
- 2013 - 2016: PhD "Ymlyniad meddyginiaeth mewn Ymchwil Glinigol a Heriau Methodolegol Cysylltiedig" (Ysgol Meddygaeth) Prifysgol Caerdydd, Caerdydd, y DU
- 2005 - 2009: BSc mewn Mathemateg, Ymchwil Weithredol ac Ystadegau (Ysgol Mathemateg) Prifysgol Caerdydd, Caerdydd, y DU (gyda blwyddyn lleoliad)
Trosolwg gyrfa:
- Hydref 2022 - Yn bresennol: Cyfarwyddwr Treialon Heintio, Llid ac Imiwnedd, Canolfan Treialon Ymchwil, Prifysgol Caerdydd
- Awst 2022 - Yn bresennol: Prif Gymrawd Ymchwil, Canolfan Treialon Ymchwil, Prifysgol Caerdydd
- Ebrill 2020 - Gorffennaf 2022: Uwch Gymrawd Ymchwil, Canolfan Treialon Ymchwil, Prifysgol Caerdydd
- Ebrill 2020 - Medi 2022: Uwch Gymrawd Ymchwil mewn Ystadegau Meddygol, Adran Gwyddorau Iechyd Gofal Sylfaenol Nuffield, Is-adran Gwyddorau Meddygol Prifysgol Rhydychen (secondiad rhan-amser)
- Mai 2018 - Mawrth 2020: Dirprwy Gyfarwyddwr Treialon Heintio, Llid ac Imiwnedd ac Uwch Gymrawd Ymchwil, Canolfan Treialon Ymchwil, Prifysgol Caerdydd
- Rhagfyr 2016 - Mai 2018: Cymrawd Ymchwil mewn Ystadegau, Canolfan Treialon Ymchwil, Prifysgol Caerdydd
- Hydref 2015 - Mawrth 2016: Gwasanaeth Methodolegol, Dylunio ac Ymddygiad Methodolegol, Prifysgol Caerdydd (secondiad rhan-amser)
- Awst 2015 - Tachwedd 2016: Cydymaith Ymchwil mewn Ystadegau, Canolfan Treialon Ymchwil, Prifysgol Caerdydd
- Mawrth 2012 - Tachwedd 2016: Cydymaith Ymchwil mewn Ystadegau, Uned Treialon De-ddwyrain Cymru, Prifysgol Caerdydd
- Mehefin 2009 - Mawrth 2012: Ystadegydd Iau, Uned Treialon De Ddwyrain Cymru, Prifysgol Caerdydd
- Gorffennaf 2007 - Medi 2008: Ystadegydd dan hyfforddiant, Uned Treialon De-ddwyrain Cymru, Prifysgol Caerdydd
Anrhydeddau a dyfarniadau
- Derbyn gwobr am Oruchwylydd Ymchwil Ôl-raddedig y Flwyddyn yr Ysgol Meddygaeth (2023)
- Enwebwyd ar gyfer Gwobr Dathlu Rhagoriaeth Prifysgol Caerdydd yng nghategori "Rising Star" (2016)
- Wedi derbyn Gwobr Cyfraniad Eithriadol gan Brifysgol Caerdydd (2016)
- Derbyn gwobr ar ôl graddio am ennill y radd uchaf ar draws yr Ysgol Mathemateg am fy nhraethawd hir BSc (2009)
Pwyllgorau ac adolygu
Pwyllgorau allanol
- Aelod presennol o'r bwrdd ar gyfer Pwyllgor Comisiynu HTA NIHR
- Arweinydd Ymchwil a Gwerthuso ar gyfer Fast Track Cymru (https://fasttrack.wales/about/)
- Aelod o Bwyllgor Goruchwylio Cynllun Gweithredu HIV Llywodraeth Cymru
- Pwyllgor Llywio Treial Annibynnol Cyfredol / Aelod Pwyllgor Monitro Data Annibynnol ar gyfer: PROMPPT, BLIPA, ATHENA, ADDEWID, CADET, GWELLA, REDUCe 2, Prawf Cyflym, COAT, a neoGASTRIC.
- Arweinydd Ymchwil a Gwerthuso blaenorol ar gyfer Fast Track Caerdydd a'r Fro (https://fasttrackcardiff.wales/)
- Aelod o bwyllgor Grŵp Diddordeb Arbennig Gofal Iechyd Sylfaenol y Gymdeithas Ystadegol Frenhinol (2011 i 2014)
- Aelod blaenorol o'r bwrdd ar gyfer panel Ymchwil ar gyfer Cleifion a Budd Cyhoeddus Ymchwil i Gleifion a Gofal Cymru (RfPPB) (2016 i 2019)
- Aelod blaenorol o'r bwrdd cyswllt ar gyfer NIHR HTA (2019 i 2021)
- Aelod annibynnol blaenorol ar gyfer nifer o TSCs ac IDMCs
- Aelod blaenorol o Grŵp Gorchwyl a Gorffen Cynllun Gweithredu HIV Llywodraeth Cymru
adolygydd cymheiriaid
- Rwy'n Olygydd Cyswllt ar gyfer Treialon
- Rwy'n aelod o'r Bwrdd Cynghori Ystadegol ar gyfer BMJ Open
- Golygydd ymgynghori blaenorol mewn ystadegau ar gyfer y Journal of Intellectual Disabilities Research.
- Yn flaenorol yn Olygydd Gwadd Argraffiad Arbennig ar gyfer y cyfnodolyn Antibiotics.
- Rwy'n adolygu cyflwyniadau i The Lancet (a chyfnodolion cysylltiedig), BMJ Open (aelod o'r bwrdd cynghori ystadegol), Journal of Infection Prevention Research, Research in Developmental Disabilities, Trials, JAIDS, AIDS and Behavior, Respiratory Medicine, a Patient Preference and Adlynence. Rwyf hefyd yn adolygu ceisiadau am gyllid ac adroddiadau terfynol ar gyfer paneli amrywiol ar draws NIHR, MRC, a HCRW.
Contact Details
GillespieD1@caerdydd.ac.uk
+44 29206 87610
Neuadd Meirionnydd, Ystafell 503, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4YS
+44 29206 87610
Neuadd Meirionnydd, Ystafell 503, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4YS
