![David Gillespie BSc, PhD](https://profiles-cardiff.imgix.net/attachments/3572?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
David Gillespie
(he/him)
BSc, PhD
Director of Infection, Inflammation & Immunity Trials and Principal Research Fellow
- Available for postgraduate supervision
Overview
I am the Director of the Infection, Inflammation & Immunity Trials Division and a Principal Research Fellow at the Centre for Trials Research.
In my role as Director, I provide senior leadership across our Infection, Inflammation & Immunity Division and am responsible for a large portfolio of trials and other well designed studies covering the following themes:
- Infectious diseases
- Vascular disorders
- Immune-mediated inflammatory conditions
I hold a five-year Health Research Fellowship awarded by Health and Care Research Wales to investigate the use of Pre-Exposure Prophylaxis (PrEP) in individuals at-risk of HIV-acquisition living in Wales.
I am also the Academic Lead for Stakeholder Engagement component of Treialon Cymru.
My background is in Medical Statistics, and I have been working on the design, conduct, analysis, and reporting of randomised trials and other well designed studies since 2007. I completed my PhD at the end of 2016, with my thesis titled “Medication Adherence in Clinical Research and Associated Methodological Challenges”.
Clinically, my research interests focus on prudent medication use in the field of infectious diseases, and my work can be broadly split into two key areas:
- Medication adherence – specifically, ways in which adherence to medication is conceptualised, measured, and modelled
- The development and evaluation of antimicrobial stewardship interventions
My areas of methodological interest include:
- Trials and general research methodology (improving the ways in which we do randomised trials and other well designed studies)
- Causal modelling (modelling approaches that aim to answer causal questions, rather than purely associational)
- Missing data (prevention of, and fitting models when there are missing data).
Publication
2024
- Stenfert Kroese, B. et al. 2024. Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT. Public Health Research 12(15) (10.3310/JTJY8001)
- Sewell, B. et al. 2024. Cost-effectiveness of C-reactive protein point of care testing for safely reducing antibiotic consumption for acute exacerbations of chronic obstructive pulmonary disease as part of the multicentre, parallel-arm, open, individually randomised, controlled PACE trial. BMJ Open 14(11), article number: e084144. (10.1136/bmjopen-2024-084144)
- Khammas, Z., Gillespie, D., Williams, A. D. N., Nicholls, J. and Wood, F. 2024. HIV Pre‐Exposure Prophylaxis (PrEP) users' experiences of PrEP access, sexual behaviour, and well‐being during the COVID‐19 pandemic: A Welsh qualitative study. Health Expectations 27(5), article number: e70064. (10.1111/hex.70064)
- Langdon, P. E. et al. 2024. Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities: the BEAMS-ID feasibility study. Health Technology Assessment 28(72), pp. 1-147. (10.3310/mwtq5721)
- Johansen, E., Nielsen, H., Gillespie, D., Aabenhus, R. and Hansen, M. P. 2024. The optimal antibiotic treatment duration for community-acquired pneumonia in adults diagnosed in general practice in Denmark (CAP-D): an open-label, pragmatic, randomised controlled trial. Trials 25, article number: 627. (10.1186/s13063-024-08477-z)
- Langdon, P. E. et al. 2024. Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities: The BEAMS ‐ ID feasibility study. Journal of Applied Research in Intellectual Disabilities 37(5), article number: e13282. (10.1111/jar.13282)
- Lowe, J. et al. 2024. Azithromycin therapy for prevention of chronic lung disease of prematurity (AZTEC): a multicentre, double-blind, randomised, placebo-controlled trial. The Lancet Respiratory Medicine 12(8), pp. 608-618. (10.1016/S2213-2600(24)00079-1)
- Lowe, J., Berrington, J., Gillespie, D., Turner, M. and Kotecha, S. 2024. Challenges of modulating the risk of bronchopulmonary dysplasia in clinical trials – Authors' reply. The Lancet Respiratory Medicine 12(8), article number: E44. (10.1016/S2213-2600(24)00173-5)
- Underwood, J., Griffiths, R., Gillespie, D., Akbari, A. and Ahmed, H. 2024. All-cause and infection-attributable mortality amongst adults with bloodstream infection—a population-based study. Open Forum Infectious Diseases 11(5), article number: ofae126. (10.1093/ofid/ofae126)
- Gillooly, A. et al. 2024. Behavioural activation for depressive symptoms in adults with severe to profound intellectual disabilities: Modelling and initial feasibility study. Journal of Applied Research in Intellectual Disabilities 37(2), article number: e13197. (10.1111/jar.13197)
- Randell, E. et al. 2024. Exploring critical intervention features and trial processes in the evaluation of sensory integration therapy for autistic children. BMC Trials 25(1), article number: 131. (10.1186/s13063-024-07957-6)
- Scior, K. et al. 2024. Digital adaptation of the Standing up for Myself intervention in young people and adults with intellectual disabilities: the STORM feasibility study. Project Report. [Online]. National Institute for Health Research. Available at: https://doi.org/10.3310/NCBU6224
2023
- Taylor, E. L. et al. 2023. Mapping and identifying service models for community-based services for children with intellectual disabilities and behaviours that challenge in England. BMC Health Services Research 23(1), article number: 1354. (10.1186/s12913-023-10388-9)
- Gillespie, D. et al. 2023. Gut microbiology of UK care home residents: cross-sectional analysis from a randomised controlled trial. Clinical Microbiology and Infection 29(11), pp. 1437-1442. (10.1016/j.cmi.2023.08.001)
- Boateng, I. et al. 2023. Using microbiological data to improve the use of antibiotics for respiratory tract infections: A protocol for an individual patient data meta-analysis. PLoS ONE 18(11), article number: e0294845. (10.1371/journal.pone.0294845)
- Courtenay, M., Gillespie, D. and Lim, R. 2023. Patterns of GP and nurse independent prescriber prescriptions for antibiotics dispensed in the community in England: a retrospective analysis. Journal of Antimicrobial Chemotherapy 78(10), pp. 2544-2553., article number: dkad267. (10.1093/jac/dkad267)
- Roberts-Tyler, E. J., Roberts, S. E., Watkins, R., Hughes, J. C., Hastings, R. P. and Gillespie, D. 2023. Effects of implementation support on children?s reading outcomes following an online early reading programme: a cluster-randomised controlled trial. British Journal of Educational Technology 54(5), pp. 1373-1396. (10.1111/bjet.13312)
- Richardson, L. et al. 2023. Standing up for Myself (STORM): Adapting and piloting a web-delivered psychosocial group intervention for people with intellectual disabilities. Research in Developmental Disabilities 137, article number: 104496. (10.1016/j.ridd.2023.104496)
- Gillespie, D. et al. 2023. Between- and within-individual sociodemographic and psychological determinants of PrEP adherence among men who have sex with men prescribed a daily PrEP regimen in Wales. AIDS and Behavior 27, pp. 1564-1572. (10.1007/s10461-022-03890-4)
- Lau, T. et al. 2023. Perspectives of statistician, microbiologist, and clinician stakeholders on the use of microbiological outcomes in randomised trials of antimicrobial stewardship interventions. Antibiotics, article number: 885. (10.3390/antibiotics12050885)
- Pickles, T., Horton, M., Christensen, K. B., Phillips, R., Gillespie, D., Mo, N. and Choy, E. 2023. P035 Patient-reported outcome measures for rheumatoid arthritis disease activity: using Rasch measurement theory to achieve more meaningful measurement. Rheumatology 62(Supp 2) (10.1093/rheumatology/kead104.076)
- Hounkpatin, H. et al. 2023. Post-consultation acute respiratory tract infection recovery: a latent class informed analysis of individual patient data from randomised controlled trials and observational studies. British Journal of General Practice 73(728), pp. e196-e203. (10.3399/BJGP.2022.0229)
- Gillespie, D. et al. 2023. Psychometric Properties of an Adapted Stigma Scale and Experiences of Stigma Associated with HIV Pre-exposure Prophylaxis Use Among Men Who have Sex with Men: A Mixed Methods Study. AIDS and Behavior (10.1007/s10461-022-03967-0)
- Pickles, T., Horton, M., Christensen, K. B., Phillips, R., Gillespie, D., Mo, N. and Choy, E. 2023. Patient reported outcome measures for rheumatoid arthritis disease activity: using Rasch measurement theory and cognitive interviewing to achieve more meaningful measurement. Presented at: ACR Convergence 2023, San Diego, 10-15 November 2023, Vol. 75. Vol. Supp 9.
2022
- Evans, A., Mantzourani, E., Gillespie, D., Hughes, L., Sharpe, G. and Yip, N. 2022. Location, location, location: does providing public health services from community pharmacies contribute to tackling health inequalities?. Journal of Public Health, article number: fdac148. (10.1093/pubmed/fdac148)
- Phillips, R. et al. 2022. Perceived threat of COVID-19, attitudes towards vaccination, and vaccine hesitancy: A prospective longitudinal study in the UK. British Journal of Health Psychology 27(4), pp. 1354-1381. (10.1111/bjhp.12606)
- Williams, A. D. N., Wood, F., Gillespie, D., Couzens, Z., Hughes, K. and Hood, K. 2022. The relationship between HIV pre-exposure prophylaxis, sexually transmitted infections, and antimicrobial resistance: a qualitative interview study of men who have sex with men. BMC Public Health 22(1), article number: 2222. (10.1186/s12889-022-14645-0)
- Carvalho, M. J. et al. 2022. Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries. Nature Microbiology 7, pp. 1337-1347. (10.1038/s41564-022-01184-y)
- Reeve, N. F. et al. 2022. Myocardial infarction and stroke subsequent to urinary tract infection (MISSOURI): protocol for a self-controlled case series using linked electronic health records. BMJ Open 12, article number: e064586. (10.1136/bmjopen-2022-064586)
- Kotecha, S. J., Course, C. W., Jones, K. E., Watkins, W. J., Berrington, J., Gillespie, D. and Kotecha, S. 2022. Follow-up study of infants recruited to the randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants: study protocol for the AZTEC-FU study. Trials 23, article number: 796. (10.1186/s13063-022-06730-x)
- Milton, R. et al. 2022. Incidence and sociodemographic, living environment and maternal health associations with stillbirth in a tertiary healthcare setting in Kano, Northern Nigeria. Short title: Incidence and factors associated with stillbirth in Kano, Nigeria. BMC Pregnancy and Childbirth 22, article number: 692. (10.1186/s12884-022-04971-x)
- Gillespie, D. et al. 2022. PrEP use, sexual behaviour, and PrEP adherence among men who have sex with men living in Wales prior to and during the COVID-19 pandemic. AIDS and Behavior 26, pp. 2746-2757. (10.1007/s10461-022-03618-4)
- Lau, T. M. M., Lowe, J., Pickles, T., Hood, K., Kotecha, S. and Gillespie, D. 2022. AZTEC—azithromycin therapy for prevention of chronic lung disease of prematurity: a statistical analysis plan for clinical outcomes. Trials 23(1), article number: 704. (10.1186/s13063-022-06604-2)
- Milosevic, S. et al. 2022. Understanding the support experiences of families of children with autism and sensory processing difficulties: A qualitative study.. Health Expectations 25(3), pp. 1118-1130. (10.1111/hex.13465)
- Randell, E. et al. 2022. Sensory integration therapy for children with autism and sensory processing difficulties: the SenITA RCT. Health Technology Assessment 26(29) (10.3310/TQGE0020)
- Neill, R., Gillespie, D. and Ahmed, H. 2022. Variation in antibiotic treatment failure outcome definitions in randomised trials and observational studies of antibiotic pre-scribing strategies: A systematic review and narrative synthesis. Antibiotics 11(5), article number: 627. (10.3390/antibiotics11050627)
- Pickles, T. et al. 2022. P089 Patient-reported outcome measures for rheumatoid arthritis disease activity: a systematic review following COSMIN guidelines. Presented at: British Society for Rheumatology Annual Conference 2022, Glasgow, Scotland, 25-27 April 2022Rheumatology Supplement 1, Vol. 61. pp. keac133.088., (10.1093/rheumatology/keac133.088)
- Hoult, G., Gillespie, D., Wilkinson, T. M. A., Thomas, M. and Francis, N. A. 2022. Biomarkers to guide the use of antibiotics for acute exacerbations of COPD (AECOPD): a systematic review and meta-analysis. BMC Pulmonary Medicine 22(1), article number: 194. (10.1186/s12890-022-01958-4)
- Gillespie, D. et al. 2022. Experiences of men who have sex with men when initiating, implementing, and persisting with HIV pre-exposure prophylaxis. Health Expectations 25(4), pp. 1332-1341. (10.1111/hex.13446)
- Pickles, T. et al. 2022. Patient reported outcome measures for rheumatoid arthritis disease activity: a systematic review following COSMIN guidelines. RMD Open 8(1), article number: e002093. (10.1136/rmdopen-2021-002093)
- Lau, T. M. M., Daniel, R., Hughes, K., Wootton, M., Hood, K. and Gillespie, D. 2022. A systematic review investigating the use of microbiology outcome measures in randomized controlled trials evaluating antimicrobial stewardship interventions published between 2011 and 2021. JAC-Antimicrobial Resistance 4(1), article number: dlac013. (10.1093/jacamr/dlac013)
- Williams, A., Gillespie, D., Couzens, Z., Wood, F., Hughes, K. and Hood, K. 2022. Changing sexual behaviours amongst MSM during the COVID-19 restrictions in Wales: a mixed methods study. BMC Public Health 22(1), article number: 396. (10.1186/s12889-022-12821-w)
- Segrott, J. et al. 2022. Effectiveness of the strengthening families programme in the UK at preventing substance misuse in 10-14 year-olds: a pragmatic randomised controlled trial. BMJ Open 12(2), article number: e049647. (10.1136/bmjopen-2021-049647)
- Gillespie, D. et al. 2022. Associations with post-consultation health-status in primary care managed acute exacerbation of COPD. International Journal of Chronic Obstructive Pulmonary Disease 2022(17), pp. 383-394. (10.2147/COPD.S340710)
- Moody, G. et al. 2022. The READ-IT study protocol for a feasibility randomised controlled trial of using a support worker/family carer mediated online reading programme to teach early reading skills to adults with intellectual disabilities. Pilot and Feasibility Studies 8(1), article number: 13. (10.1186/s40814-022-00972-x)
- Milton, R. et al. 2022. Determinants of stillbirth from two observational studies investigating deliveries in Kano, Nigeria. Frontiers in Global Women's Health 2, article number: 788157. (10.3389/fgwh.2021.788157)
2021
- Coulman, E. et al. 2021. Early positive approaches to support (E-PAtS) for families of young children with intellectual disability: a feasibility randomised controlled trial. Frontiers in Psychiatry 12, article number: 729129. (10.3389/fpsyt.2021.729129)
- Ahmed, H., Gillespie, D. and Thomas-Jones, E. 2021. Effect of 7 vs 14 days of antibiotics among afebrile men with urinary tract infection. Journal of the American Medical Association 326(20), article number: 2080. (10.1001/jama.2021.16738)
- Phillips, R. et al. 2021. Cohort profile: The UK COVID-19 Public Experiences (COPE) prospective longitudinal mixed-methods study of health and well-being during the SARSCoV2 coronavirus pandemic. PLoS ONE 16(10), article number: e0258484. (10.1371/journal.pone.0258484)
- Read, S. et al. 2021. Normalisation process theory and the implementation of a new glaucoma clinical pathway in hospital eye services: perspectives of doctors, nurses and optometrists. PLoS ONE 16(8), article number: e0255564. (10.1371/journal.pone.0255564)
- Gillespie, D. et al. 2021. Early impact of COVID-19 social distancing measures on reported sexual behaviour of HIV pre-exposure prophylaxis users in Wales. Sexually Transmitted Infections 97, pp. 85-87. (10.1136/sextrans-2020-054598)
- Gillespie, D. et al. 2021. Associations with antibiotic prescribing for acute exacerbation of COPD in primary care: secondary analysis of a randomised controlled trial. British Journal of General Practice 71(705), pp. e266-e272. (10.3399/BJGP.2020.0823)
- Sands, K. et al. 2021. Characterization of antimicrobial resistant Gram-negative bacteria that cause neonatal sepsis in seven low and middle-income countries. Nature Microbiology 6, pp. 512–523. (10.1038/s41564-021-00870-7)
- Butler, C. C. et al. 2021. Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT. Efficacy and Mechanism Evaluation 8(7) (10.3310/eme08070)
- Stuart, B. et al. 2021. Delayed antibiotic prescribing for respiratory tract infections: an individual patient data meta-analysis. BMJ 372, article number: n808. (10.1136/bmj.n808)
- Castro-Herrera, V. M. et al. 2021. Combination of the probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis, BB-12 has limited effect on biomarkers of immunity and inflammation in older people resident in care homes: results from the Probiotics to Reduce Infections iN CarE home reSidentS Randomized, Controlled Trial. Frontiers in Immunology 12, article number: 643321. (10.3389/fimmu.2021.643321)
- Felloner, J. et al. 2021. A multi-stakeholder approach to the co-production of the research agenda for medicines optimisation. BMC Health Services Research 21, article number: 64. (10.1186/s12913-021-06056-5)
- M.Castro-Herrera, V. et al. 2021. Relationship between age, frailty, length of care home residence and biomarkers of immunity and inflammation in older care residents in the UK. Frontiers in Aging 2, article number: 599084. (10.3389/fragi.2021.599084)
2020
- Waterman, H. et al. 2020. Acceptability, adherence and economic analyses of a new clinical pathway for the identification of non-responders to glaucoma eye drops: a prospective observational study. British Journal of Ophthalmology 104(12), pp. 1704-1709. (10.1136/bjophthalmol-2019-315436)
- Francis, N. A. et al. 2020. Clinical features and c-reactive protein as predictors of bacterial exacerbations of COPD. International Journal of Chronic Obstructive Pulmonary Disease 2020, pp. 3147-3158. (10.2147/COPD.S265674)
- Lowe, J. et al. 2020. Study protocol: azithromycin therapy for chronic lung disease of prematurity (AZTEC) - a randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants. BMJ Open 10(10), article number: e041528. (10.1136/bmjopen-2020-041528)
- Alghamdi, S. et al. 2020. Prescribing trends over time by non-medical independent prescribers (NMIPs) in primary care settings across Wales (2011-2018): a secondary database analysis. BMJ Open 10, article number: e036379. (10.1136/bmjopen-2019-036379)
- Coulman, E. et al. 2020. The Early Positive Approaches to Support (E-PAtS) study: study protocol for a feasibility cluster randomised controlled trial of a group programme (E-PAtS) for family caregivers of young children with intellectual disability. Pilot and Feasibility Studies 6(1), article number: 147. (10.1186/s40814-020-00689-9)
- Phillips, R. et al. 2020. C-Reactive Protein-guided antibiotic prescribing for COPD exacerbations: a qualitative evaluation. British Journal of General Practice 70(696), pp. e505-e523. (10.3399/bjgp20X709865)
- Butler, C. C. et al. 2020. Effect of probiotic use on antibiotic administration among care home residents: a randomized clinical trial. Journal of the American Medical Association 324(1), pp. 47 - 56. (10.1001/jama.2020.8556)
- Schofield, B., Gregory, C., Gal, M., Gillespie, D., Naik, G., Hay, A. and Francis, N. 2020. The feasibility of measuring calprotectin from a throat swab as a marker of infections caused by group A streptococcus: a case–control feasibility study. BJGP Open 4(2), article number: 20X101006. (10.3399/bjgpopen20X101006)
- Lim, R. et al. 2020. Theory-based electronic learning intervention to support appropriate antibiotic prescribing by nurse and pharmacist independent prescribers: an acceptability and feasibility experimental study using mixed methods. BMJ Open 10(6), article number: e036181. (10.1136/bmjopen-2019-036181)
- Francis, N. A. et al. 2020. C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT. Health Technology Assessment 24, article number: 15. (10.3310/hta24150)
- Read, S. et al. 2020. Chronic conditions and behavioural change approaches to medication adherence: rethinking clinical guidance and recommendations. Patient Preference and Adherence 14, pp. 581-586., article number: 52446. (10.2147/PPA.S239916)
2019
- Courtenay, M. et al. 2019. A theory-based electronic learning intervention to support appropriate antibiotic prescribing by nurses and pharmacists: intervention development and feasibility study protocol. BMJ Open 9(8), article number: e028326. (10.1136/bmjopen-2018-028326)
- Butler, C. C. et al. 2019. C-reactive protein testing to guide antibiotic prescribing for COPD exacerbations. New England Journal of Medicine 381, pp. 111-120. (10.1056/NEJMoa1803185)
- Drew, C. J. G. et al. 2019. A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial). Pilot and Feasibility Studies 5(1), article number: 87. (10.1186/s40814-019-0474-x)
- Owen-Jones, E. et al. 2019. Protocol for a double-blind placebo-controlled trial to evaluate the efficacy of probiotics in reducing antibiotics for infection in care home residents: the Probiotics to Reduce Infections iN CarE home reSidentS (PRINCESS) trial. BMJ Open 9(6), article number: e027513. (10.1136/bmjopen-2018-027513)
- Randell, E. et al. 2019. Sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children: study protocol for a pragmatic randomised controlled trial.. Trials 20, article number: 113. (10.1186/s13063-019-3205-y)
- Stuart, B. et al. 2019. Delayed antibiotic prescribing for respiratory tract infections: protocol of an individual patient data meta-analysis. BMJ Open 9(1), pp. -., article number: e026925. (10.1136/bmjopen-2018-026925)
- Nollett, C. et al. 2019. Depressive symptoms in people with a vision impairment: A cross-sectional study to identify who is most at risk. BMJ Open 9(1), article number: e026163. (10.1136/bmjopen-2018-026163)
- Flynn, S., Hastings, R., McNamara, R., Gillespie, D., Randell, E., Richards, L. and Taylor, Z. 2019. Who’s challenging who?: A co-produced approach for training staff in learning disability services about challenging behaviour. Tizard Learning Disability Review 24(4), pp. 192-199. (10.1108/TLDR-03-2019-0013)
2018
- Flynn, S., Hastings, R., Gillespie, D., McNamara, R. and Randell, E. 2018. Is the amount of exposure to aggressive challenging behaviour related to staff work-related 14 well-being in intellectual disability services? Evidence from a clustered research design.. Research in Developmental Disabilities 81, pp. 155-161. (10.1016/j.ridd.2018.04.006)
- Hastings, R. et al. 2018. Who’s challenging who training for staff empathy towards adults with challenging behaviour: cluster randomised controlled trial. Journal of Intellectual Disability Research 62(9), pp. 798-813. (10.1111/jir.12536)
- Gillespie, D., Francis, N. A., Carrol, E. D., Thomas-Jones, E., Butler, C. C. and Hood, K. 2018. Use of co-primary outcomes for trials of antimicrobial stewardship interventions. Lancet Infectious Diseases 18(6), pp. 595-597. (10.1016/S1473-3099(18)30289-5)
- Butler, C. C. et al. 2018. Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness. British Journal of General Practice 68(669), pp. e268-e278. (10.3399/bjgp18X695285)
2017
- Segrott, J. et al. 2017. An application of Extended Normalisation Process Theory in a randomised controlled trial of a complex social intervention: process evaluation of the Strengthening Families Programme (10-14) in Wales, UK. SSM - Population Health 3, pp. 255-265. (10.1016/j.ssmph.2017.01.002)
- Butler, C. C. et al. 2017. Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study. British Journal of General Practice 67(665), pp. e830-e841. (10.3399/bjgp17X693641)
- Courtenay, M., Gillespie, D. and Lim, R. 2017. Patterns of dispensed non-medical prescriber prescriptions for antibiotics in primary care across England: a retrospective analysis. Journal of Antimicrobial Chemotherapy 72(10) (10.1093/jac/dkx230)
- Bates, J. et al. 2017. General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial. Trials 18, article number: 422. (10.1186/s13063-017-2144-8)
- McNamara, R. et al. 2017. A pilot randomised controlled trial of community-led ANtipsychotic Drug REduction for Adults with Learning Disabilities. Project Report. [Online]. Health Technology Assessment. Available at: https://doi.org/10.3310/hta21470
- Gillespie, D. et al. 2017. Determinants of initiation, implementation, and discontinuation of amoxicillin by adults with acute cough in primary care. Patient Preference and Adherence 2017(11), pp. 561-569. (10.2147/PPA.S119256)
- Gillespie, D. et al. 2017. The use of randomisation-based efficacy estimators in non-inferiority trials. Trials 18(1), article number: 117. (10.1186/s13063-017-1837-3)
2015
- Gillespie, D. et al. 2015. The use of randomisation-based efficacy estimators in non-inferiority trials [Poster Presentation]. Trials 16(Suppl), pp. P129. (10.1186/1745-6215-16-S2-P129)
- Gillespie, D. et al. 2015. Antibiotic prescribing and associated diarrhoea: a prospective cohort study of care home residents. Age and Ageing 44(5), pp. 853-860. (10.1093/ageing/afv072)
- Simpson, S. A. et al. 2015. A feasibility randomised controlled trial of a motivational interviewing-based intervention for weight loss maintenance in adults. Health Technology Assessment 19(50) (10.3310/hta19500)
- Gillespie, D. et al. 2015. Adherence-adjusted estimates of benefits and harms from treatment with amoxicillin for LRTI: secondary analysis of a 12-country randomised placebo- controlled trial using randomisation- based efficacy estimators. BMJ Open 5, article number: e006160. (10.1136/bmjopen-2014-006160)
2014
- Hood, K. et al. 2014. Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes. Health Technology Assessment 18(63) (10.3310/hta18630)
- Gillespie, D., Hood, K., Farewell, D., Stenson, R., Probert, C. and Hawthorne, A. B. 2014. Electronic monitoring of medication adherence in a 1-year clinical study of 2 dosing regimens of mesalazine for adults in remission with ulcerative colitis. Inflammatory Bowel Diseases 20(1), pp. 82-91. (10.1097/01.MIB.0000437500.60546.2a)
- Segrott, J. et al. 2014. Preventing substance misuse: study protocol for a randomised controlled trial of the Strengthening Families Programme 10-14 UK (SFP 10-14 UK). BMC Public Health 14(1), article number: 49. (10.1186/1471-2458-14-49)
- Segrott, J. et al. 2014. Fidelity of implementation of the Strengthening Families Programme 10-14 UK in Wales UK: a mixed-method process evaluation within a randomised controlled trial. Presented at: 7th European Public Health Conference, Glasgow, Scotland,, 19-22 November 2014.
- Moore, L. A. R. et al. 2014. Strengthening Families Programme (10-14UK) substance misuse prevention programme: findings from NPRI randomised trial of a proportionate universalism adaptation of an intervention for families with children aged 10-14. Presented at: 10th UKSBM Annual Scientific Meeting, Nottingham, 3-4 December 2014. pp. 1642-1647.
2013
- Rose, J. et al. 2013. Different factors influence self-reports and third-party reports of anger by adults with intellectual disabilities. Journal of Applied Research in Intellectual Disabilities 26(5), pp. 410-419. (10.1111/jar.12037)
- Mustafa, M., Carson-Stevens, A., Gillespie, D. and Edwards, A. G. 2013. Psychological interventions for women with metastatic breast cancer. Cochrane Library 2013(6), article number: CD004253. (10.1002/14651858.CD004253.pub4)
- Willner, P. et al. 2013. Group-based cognitive-behavioural anger management for people with mild to moderate intellectual disabilities: cluster randomised controlled trial. The British Journal of Psychiatry 203, pp. 288-296. (10.1192/bjp.bp.112.124529)
2012
- Hawthorne, A. B. et al. 2012. One-year investigator-blind randomized multicenter trial comparing asacol 2.4 g once daily with 800 mg three times daily for maintenance of remission in ulcerative colitis. Inflammatory Bowel Diseases 18(10), pp. 1885-1893. (10.1002/ibd.21938)
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2011
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2010
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2009
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- Mustafa, M., Carson-Stevens, A., Gillespie, D. and Edwards, A. G. 2013. Psychological interventions for women with metastatic breast cancer. Cochrane Library 2013(6), article number: CD004253. (10.1002/14651858.CD004253.pub4)
- Willner, P. et al. 2013. Group-based cognitive-behavioural anger management for people with mild to moderate intellectual disabilities: cluster randomised controlled trial. The British Journal of Psychiatry 203, pp. 288-296. (10.1192/bjp.bp.112.124529)
- Hawthorne, A. B. et al. 2012. One-year investigator-blind randomized multicenter trial comparing asacol 2.4 g once daily with 800 mg three times daily for maintenance of remission in ulcerative colitis. Inflammatory Bowel Diseases 18(10), pp. 1885-1893. (10.1002/ibd.21938)
- Francis, N. A. et al. 2012. Delayed antibiotic prescribing and associated antibiotic consumption in adults with acute cough. British Journal of General Practice (BJGP) 62(602), pp. e639-e646. (10.3399/bjgp12X654614)
- Allen, D. A. et al. 2012. Continuity of care in the transition from child to adult diabetes services: A realistic evaluation study. Journal of Health Services Research and Policy 17(3), pp. 140-148. (10.1258/jhsrp.2011.011044)
- Francis, N. A. et al. 2012. Antibiotics for acute cough: an international observational study of patient adherence in primary care. British Journal of General Practice (BJGP) 62(599), pp. e429-e437. (10.3399/bjgp12X649124)
- Butler, C. C. et al. 2012. Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomised controlled trial. British Medical Journal (BMJ) 344, article number: d8173. (10.1136/bmj.d8173)
- Hood, K. et al. 2012. Mode of data elicitation, acquisition and response to surveys: a systematic review. Health Technology Assessment 16(27) (10.3310/hta16270)
- Willner, P. et al. 2011. Anger management for people with mild to moderate learning disabilities: study protocol for a multi-centre cluster randomized controlled trial of a manualized intervention delivered by day-service staff. Trials 12, pp. 36-47. (10.1186/1745-6215-12-36)
- Stanton, N. et al. 2010. Are smokers with acute cough in primary care prescribed antibiotics more often, and to what benefit? An observational study in 13 European countries. European Respiratory Journal 35(4), pp. 761-767. (10.1183/09031936.00168409)
- Butler, C. C. et al. 2009. Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries. BMJ 338, article number: b2242. (10.1136/bmj.b2242)
Monograffau
- Scior, K. et al. 2024. Digital adaptation of the Standing up for Myself intervention in young people and adults with intellectual disabilities: the STORM feasibility study. Project Report. [Online]. National Institute for Health Research. Available at: https://doi.org/10.3310/NCBU6224
- McNamara, R. et al. 2017. A pilot randomised controlled trial of community-led ANtipsychotic Drug REduction for Adults with Learning Disabilities. Project Report. [Online]. Health Technology Assessment. Available at: https://doi.org/10.3310/hta21470
- Allen, D. A. et al. 2010. The transition from paediatric to adult diabetes services: what works, for whom and in what circumstances? [Final report. NIHR Service Delivery and Organisation programme]. Project Report. [Online]. HMSO. Available at: http://www.netscc.ac.uk/hsdr/files/project/SDO_FR_08-1504-107_V01.pdf
Research
I have been awarded approximately >£37m in grant funding across 40 grants, including £0.5m as lead investigator and >£7m for international research.
Research grants (most recent first):
2023
- Harding, et al. IntraVESical Preparations for Recurrent Urinary TrAct Infection Prevention (The VESPA Study): a multi-arm, multi-site open label randomised superiority trial. NIHR HTA. £2.1M.
- Kotecha, et al. Bacterial mucosal immunotherapy for prevention of wheeze in preterm born infants (BALLOON Trial). NIHR/MRC EME. £2.7M.
- Edwards, et al. Self-cleaning material with photo-active catalysis: field trials in Nepal. BMGF. £658K.
- Pallmann P and Carrol E, et al. Platform randomised evaluation of clinical outcomes using novel technologies to optimise antimicrobial therapy (PROTECT). NIHR HTA. £204,987.
2022
- Gore N, et al. A Cluster Randomised Controlled Trial of Early Positive Approaches to Support (E-PAtS) for families of young children with intellectual disability. NIHR PHR. £1.9m.
- Hayward G, Llewelyn M, et al. Impact of duration of antibiotic therapy on effectiveness, safety and selection of antibiotic resistance in adult women with urinary tract infections (UTI): a randomised controlled trial. NIHR HTA. £2.4m.
- Channon S, et al. Scoping the feasibility of developing and evaluating a peer support service for people living with HIV in Wales. Public Health Wales. £32,000.
- Courtenay M, et al. Theory-based electronic learning intervention to support appropriate antibiotic prescribing by nurse and pharmacist prescribers: an acceptability and feasibility experimental study. Innovation for All. £2,150.
2021
- Jones L, et al. The epidemiology and impact of bacterial secondary infections and antimicrobial resistance on Intensive Care during the SARS-CoV-2 pandemic. HCRW Health Grant. £175,517
- Ahmed H, et al. Myocardial Infarction and Stroke Subsequent tO URInary tract infection (MISSOURI). BHF Research Grant. £220,000.
- Nicholls J, Gillespie D. Optimising HIV Prevention and pre-exposure prophylaxis (PrEP) service delivery models for all populations in Cardiff/Wales. HCRW NHS Research Time Award. £89,000.
- Stone J, et al. Context-specific factors that drive HIV transmission among men who have sex with men: Modelling the role of behavioural, social and legal factors. GW4 PhD Studentship.
- Butler CC, et al. Presentation, management and outcomes of RSV infection in adults in primary care: individual patient meta-analysis. Janssen Clinical Investigator-Initiated Study.
2020
- Langdon P, et al. Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities (BEAMS – ID). NIHR HTA. £200,000.
- Hastings R, et al. Mapping and Evaluating Services for Children with Learning Disabilities and Behaviours that Challenge (MELD). NIHR HS&DR. £1,200,000.
- Holmes E, et al. The Economics of Rapid Diagnostics to Reduce Antibiotic Prescribing in NHS Wales (TRaDe). HCRW HRF. £350,000.
- Gillespie D, et al. The use of modern modelling methods for the statistical analysis of microbiological data in clinical trials of antimicrobial stewardship interventions. School of Medicine / Trials Methodology Research Partnership PhD studentship.
- Phillips R, et al. COVID-19 public experiences in Wales: A longitudinal mixed-methods study of attitudes, beliefs, and behaviour in response to the coronavirus pandemic (COPE Cymru). Ser Cymru Call for COVID-19 Research. £130,000.
- Waterman H, et al. Examining assumptions, accuracy and acceptance of an electronic monitoring device for adherence to eye drops: the EASY label study. International Glaucoma Association. £30,000.
2019
- Hood K, et al. Health and Care Research Wales. Centre for Trials Research Infrastructure renewal. £2,500,000.
- Stenfert-Kroese B, et al. A randomised feasibility study of a school-based emotional literacy programme (Zippy's Friends) for children with intellectual disabilities (ZIP-SEND). NIHR PHR. £550,000.
- Scior K, et al. The STanding up fOR Myself (STORM) psychosocial group intervention for young people and adults with intellectual disabilities: Feasibility study. NIHR PHR. £600,000.
- Marsal S, et al. DocTIS - Decision on optimal combinatorial therapies in IMIDs using systems approaches. H2020. €7,000,000.
- Solomon T, et al. Enceph-IG - Intravenous Immunoglobulin in Autoimmune Encephalitis in Adults: A Randomised Double-Blind Placebo-Controlled Trial. NIHR/MRC EME. £2,400,000.
- Denne L, et al. Teaching early reading skills to adults with intellectual disabilities (READ-IT) using a support worker/family carer mediated on-line reading programme – a feasibility study. NIHR RfPB. £250,000.
- Pickles T, et al. Patient reported outcome measures for Rheumatoid Arthritis symptom severity. Development of a computer adaptive test from an item bank using Rasch measurement theory (SOCRATES). NIHR Doctoral Fellowship. £350,000.
- Gillespie D and Hood K, et al. Understanding the relationship between pre-exposure prophylaxis, sexually transmitted infections, and antimicrobial resistance in Wales. KESS2 East. £50,000.
- Kotecha S, et al. AZithromycin ThErapy for Chronic lung disease (AZTEC): A randomised, placebo controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants. NIHR HTA. £2,100,000.
2018
- Gillespie D, et al. Development of an intervention to optimise use of pre-exposure prophylaxis (PrEP) to prevent HIV-acquisition in at-risk individuals living in Wales (DO-PrEP). Health and Care Research Wales Health Research Fellowship. £430,000.
- Walsh T, et al. Burden of Antibiotic Resistance in Neonates from Developing Societies - Epidemiological and Genomic Analyses of BARNARDS Network. Bill and Melinda Gates Foundation. £600,000.
2017
- Jahoda A, et al. Behavioural activation (BeatIt) for depression in adults with severe intellectual disabilities. A feasibility randomised controlled study of BeatIt versus treatment as usual. The Baily Thomas Charitable Fund. £100,000.
- Hastings R, et al. Early Positive Approaches to Support (E-PAtS) for families of young children with intellectual disability: Feasibility study. NIHR PHR. £500,000.
- Courtenay M et al. An intervention for primary care prescribers to support the choice and use of antibiotics. ESRC IAA. £20,000.
- Rosser A, et al. Trial designs for delivery of novel therapies for neurodegeneration (TRIDENT). £220,000.
- Waterman H, et al. Feasibility and Acceptability of a new Clinical Pathway for the Identification of Non-Responders to Glaucoma Eye Drops (the TRIAGE study). Health and Care Research Wales RfPPB. £225,000.
2015
- Butler CC, et al. Probiotics to reduce infections in care home residents (PRINCESS). NIHR/MRC EME. £1,900,000.
- McNamara R, et al. A pragmatic randomised controlled trial of sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children, and its impact on behavioural difficulties, adaptive skills and socialisation (SenITA). NIHR HTA. £1,500,000.
2014
- Butler CC and Francis NA, et al. General Practitioner (GP) use of a C-Reactive Protein (CRP) Point of Care Test (POCT) to help target antibiotic prescribing to patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) who are most likely to benefit (PACE). NIHR HTA. £1,400,000.
2013
- Kerr M, et al. Community-led anti-psychotic drug reduction for adults with learning disabilities: a randomised double-blind placebo controlled trial (ANDREA-LD). £1,500,000.
Teaching
Teaching
- Since 2023, I have given an invited guest lecture for University College Dublin's Master's in Public Health Clinical Trials Module titled "Designing and analysing randomised trials of antibiotic stewardship interventions".
- Since 2019/2020, I have delivered a lecture on "Randomised trials of treatment strategies to help improve antibiotic prescribing and infection-related outcomes" for the Acute Conditions Module of the Population Health Intercalated BSc.
- During the 2018/2019 and 2019/2020 academic years I ran sessions on developing study protocols as part of the Research Methods 2 module for Medical Intercalated BSc students
- In June 2016, I co-developed and delivered a three-day course on basic data analysis using the statistical programming language R (titled "learnR") to staff at the University of Namibia as part of the Phoenix Project (http://www.cardiff.ac.uk/phoenix-project)
- Previously, I have taught small and medium group sizes at both undergraduate and postgraduate level on topics including quantitative research methods, statistics, and critical appraisal
Supervision
- I have previously supervised both undergraduate and post-graduate students in the School of Medicine, School of Pharmacy, and School of Mathematics, and School of Psychology (at University of Bath) on topics such as methodological aspects around the evaluation of antimicrobial stewardship interventions, medication use and medication adherence, and HIV-stigma.
I have supervised the following PhD students to completion:
Adam Williams (co-lead supervisor): Understanding the relationship between PrEP, STIs, and AMR in Wales
Timothy Pickles (co-supervisor): Patient-reported outcome measures for rheumatoid arthritis symptom severity: development of a computer adaptive test from an item bank using Rasch measurement theory
I am currently supervising the following registered PhD students:
Mandy Lau (co-lead supervisor): The use of modern modelling methods for the statistical analysis of microbiological data in clinical trials of antimicrobial stewardship interventions (https://www.cardiff.ac.uk/people/view/362467-lau-mandy)
Saher Aijaz Khan (co-supervisor, led from University of Bristol): Context-specific factors that drive HIV transmission among men who have sex with men: Modelling the role of behavioural, social and legal factors (https://gw4biomed.ac.uk/cohort-6/)
Eskild Johansen (co-supervisor, led from Aalborg University): The optimal antibiotic treatment duration for community-acquired pneumonia in adults diagnosed in general practice in Denmark: an open-label, pragmatic, randomised controlled trial (https://vbn.aau.dk/en/persons/142036)
Biography
Education and qualifications:
- 2013 - 2016: PhD "Medication Adherence in Clinical Research and Associated Methodological Challenges" (School of Medicine) Cardiff University, Cardiff, UK
- 2005 - 2009: BSc in Mathematics, Operational Research and Statistics (School of Mathematics) Cardiff University, Cardiff, UK (with placement year)
Career overview:
- October 2022 - Present: Director of Infection, Inflammation & Immunity Trials, Centre for Trials Research, Cardiff University
- August 2022 - Present: Principal Research Fellow, Centre for Trials Research, Cardiff University
- April 2020 - July 2022: Senior Research Fellow, Centre for Trials Research, Cardiff University
- April 2020 - September 2022: Senior Research Fellow in Medical Statistics, Nuffield Department of Primary Care Health Sciences, Medical Sciences Division, University of Oxford (part-time secondment)
- May 2018 - March 2020: Deputy Director of Infection, Inflammation & Immunity Trials and Senior Research Fellow, Centre for Trials Research, Cardiff University
- December 2016 - May 2018: Research Fellow in Statistics, Centre for Trials Research, Cardiff University
- October 2015 - March 2016: Methodological Consultant, Research Design and Conduct Service, Cardiff University (part-time secondment)
- August 2015 - November 2016: Research Associate in Statistics, Centre for Trials Research, Cardiff University
- March 2012 - November 2016: Research Associate in Statistics, South East Wales Trials Unit, Cardiff University
- June 2009 - March 2012: Junior Statistician, South East Wales Trials Unit, Cardiff University
- July 2007 - September 2008: Trainee Statistician, South East Wales Trials Unit, Cardiff University
Honours and awards
- Received an award for School of Medicine Post Graduate Research Supervisor of the Year (2023)
- Nominated for a Cardiff University Celebrating Excellence Award in the category of "Rising Star" (2016)
- Received an Outstanding Contribution Award from Cardiff University (2016)
- Received a prize at graduation for achieving the highest grade across the School of Mathematics for my BSc dissertation (2009)
Committees and reviewing
External committees
- Current board member for NIHR HTA Commissioning Committee
- Research and Evaluation Lead for Fast Track Cymru (https://fasttrack.wales/about/)
- Member of the Welsh Government's HIV Action Plan Oversight Committee
- Current Independent Trial Steering Committee / Independent Data Monitoring committee member for: PROMPPT, BLIPA, ATHENA, PROMISE, CADET, IMPROVE, REDUCe 2, Rapid Test, COAT, and neoGASTRIC.
- Previous Research and Evaluation Lead for Fast Track Cardiff & Vale (https://fasttrackcardiff.wales/)
- Previous Royal Statistical Society Primary Healthcare Special Interest Group committee member (2011 to 2014)
- Previous board member for the Health and Care Research Wales Research for Patient and Public Benefit (RfPPB) panel (2016 to 2019)
- Previous associate board member for NIHR HTA (2019 to 2021)
- Previous independent member for several TSCs and IDMCs
- Previous member of Welsh Government's HIV Action Plan Task & Finish Group
Peer reviewer
- I am an Associate Editor for Trials
- I am on the Statistical Advisory Board for the BMJ Open
- Previously consulting editor in statistics for the Journal of Intellectual Disabilities Research.
- Previously a Special Edition Guest Editor for the journal Antibiotics.
- I peer-review submissions to The Lancet (and associated journals), BMJ Open (statistical advisory board member), Journal of Infection Prevention Research, Research in Developmental Disabilities, Trials, JAIDS, AIDS and Behavior, Respiratory Medicine, and Patient Preference and Adherence. I also review funding applications and final reports for various panels across NIHR, MRC, and HCRW.
Contact Details
GillespieD1@cardiff.ac.uk
+44 29206 87610
Neuadd Meirionnydd, Room 503, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS
+44 29206 87610
Neuadd Meirionnydd, Room 503, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS
