Yr Athro William Gray

Timau a rolau for William Gray

Athro Niwrolawdriniaeth Swyddogaethol, Sefydliad Arloesi Niwrowyddoniaeth ac Iechyd Meddwl
Yr Ysgol Meddygaeth

Fi yw cyfarwyddwr Uned BRAIN a ariennir gan Ymchwil Iechyd a Gofal Cymru ac yn Athro Niwrolawdriniaeth. Rwy'n gwneud ymchwil glinigol mewn epilepsi, yr hipocampws, dysgu a'r cof.

Mae fy ymchwil yn cynnwys delweddu cleifion epilepsi i ddeall tarddiad trawiad a chamweithrediad gwybyddol, recordiadau EEG mewnwranol, delweddu ffrydiau ffibr mater gwyn, strwythur mater llwyd delweddu, microstrwythur a fMRI.

Date
Type

2014

Gray, W. P. and Cheung, A. 2014. Nitric oxide regulation of adult neurogenesis. In: Litwack, G. ed. Vitamins and Hormones. Vol. 96, Elsevier. , pp.59-77. (10.1016/B978-0-12-800254-4.00004-0)
Coulter, I. C. et al., 2014. Proposal for a prospective multi-centre audit of chronic subdural haematoma management in the United Kingdom and Ireland. British Journal of Neurosurgery 28 (2), pp.199-203. (10.3109/02688697.2013.835378)
Kolias, A. G. et al., 2014. Chronic subdural haematoma: How can we improve patient care and outcomes?. British Journal of Neurosurgery 28 (1), pp.136-137. (10.3109/02688697.2013.869555)
Nunan, R. et al., 2014. Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release. Glia 62 (8), pp.1313-1327. (10.1002/glia.22682)
Stevens, O. A. C. et al., 2014. A low background Raman probe for optical biopsy of brain tissue. Presented at: Biomedical Vibrational Spectroscopy VI: Advances in Research and Industry San Francisco, CA, USA 1 February 2014. Published in: Mahadevan-Jansen, A. and Petrich, W. eds. Proc. SPIE 8939, Biomedical Vibrational Spectroscopy VI: Advances in Research and Industry. Vol. 8939.Society of Photo-Optical Instrumentation Engineers. , pp.89390W. (10.1117/12.2044139)

2013

Kolias, A. G. et al., 2013. A report from the inaugural meeting of the British Neurosurgical Trainee Research Collaborative held in the Royal College of Surgeons of England, 19 October 2012. British Journal of Neurosurgery 27 (3), pp.307-310. (10.3109/02688697.2013.781122)
Kolias, A. G. et al., 2013. A report from the inaugural meeting of the British Neurosurgical Trainee Research Collaborative held in the Royal College of Surgeons of England, 19 October 2012 [Article]. British Journal of Neurosurgery 27 (3), pp.307-310. (10.3109/02688697.2013.781122)
Beaton, A. E. et al., 2013. Corrigendum to “Transsylvian selective amygdalohippocampectomy in children with hippocampal sclerosis: Seizure, intellectual and memory outcome” [Seizure 21 (2012) 699–705]. Seizure - European Journal of Epilepsy 22 (5), pp.411. (10.1016/j.seizure.2013.02.004)
Cenydd, L. A. et al., 2013. A tablet-based neurosurgery training tool. In: Medicine Meets Virtual Reality 20. Studies in health technology and informatics IoS Press. , pp.20-23.
Howell, O. W. et al., 2013. Corrigendum to 'Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus' [Neurobiol. Dis. 26/1 (2007) 174?188]. Neurobiology of Disease 49 , pp.199. (10.1016/j.nbd.2012.06.006)
Jiruska, P. et al., 2013. Dentate gyrus progenitor cell proliferation after the onset of spontaneous seizures in the tetanus toxin model of temporal lobe epilepsy. Neurobiology of Disease 54 , pp.492-498. (10.1016/j.nbd.2013.02.001)
Renzel, R. et al., 2013. Polarized distribution of AMPA, but not GABAA, receptors in radial glia-like cells of the adult dentate gyrus. Glia 61 (7), pp.1146-1154. (10.1002/glia.22505)
Zaben, M. J. A. and Gray, W. P. 2013. Neuropeptides and hippocampal neurogenesis. Neuropeptides 47 (6), pp.431-438. (10.1016/j.npep.2013.10.002)

2012

Cheung, A. et al., 2012. Intracellular nitric oxide mediates neuroproliferative effect of neuropeptide Y on postnatal hippocampal precursor cells. Journal of Biological Chemistry 287 (24), pp.20187-20196. (10.1074/jbc.M112.346783)
Ahmed, A. I. et al., 2012. Endogenous GFAP-positive neural stem/progenitor cells in the postnatal mouse cortex are activated following traumatic brain injury. Journal of Neurotrauma 29 (5), pp.828-842. (10.1089/neu.2011.1923)
Barkas, L. et al., 2012. Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy. Brain: a Journal of Neurology 135 (8), pp.2358-2374. (10.1093/brain/aws176)
Beaton, A. E. et al., 2012. Transsylvian selective amygdalohippocampectomy in children with hippocampal sclerosis: Seizure, intellectual and memory outcome. Seizure - European Journal of Epilepsy 21 (9), pp.699-705. (10.1016/j.seizure.2012.07.012)
Bulstrode, H. et al., 2012. A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells. Cancer Letters 326 (1), pp.79-87. (10.1016/j.canlet.2012.07.022)
Rodgers, W. P. et al., 2012. Interrater reliability of Engel, International League Against Epilepsy, and McHugh seizure outcome classifications following vagus nerve stimulator implantation. Journal of Neurosurgery: Pediatrics 10 (3), pp.226-229. (10.3171/2012.6.PEDS11424)

2011

Abbosh, C. et al., 2011. GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors. Journal of Neurochemistry 117 (3), pp.425-436. (10.1111/j.1471-4159.2011.07204.x)
Ahmed, A. , Zaben, M. J. A. and Gray, W. P. 2011. Stem cells in the adult human brain. British Journal of Neurosurgery 25 (1), pp.28-37. (10.3109/02688697.2010.525264)
Durnford, A. et al., 2011. Very good inter-rater reliability of Engel and ILAE epilepsy surgery outcome classifications in a series of 76 patients. Seizure - European Journal of Epilepsy 20 (10), pp.809-812. (10.1016/j.seizure.2011.08.004)
Sadek, A. and Gray, W. P. 2011. Chopping and changing: long-term results of epilepsy surgery. The Lancet 378 (9800), pp.1360-1362. (10.1016/S0140-6736(11)61593-6)
Sadek, A. et al., 2011. Seizure-induced miosis. Epilepsia 52 (12), pp.e199-e203. (10.1111/j.1528-1167.2011.03310.x)

2010

Barkas, L. et al., 2010. Selective temporal resections and spatial memory impairment: Cue dependent lateralization effects. Behavioural Brain Research 208 (2), pp.535-544. (10.1016/j.bbr.2009.12.035)
Rodrigo, C. et al., 2010. NPY augments the proliferative effect of FGF2 and increases the expression of FGFR1 on nestin positive postnatal hippocampal precursor cells, via the Y1 receptor. Journal of Neurochemistry 113 (3), pp.615-627. (10.1111/j.1471-4159.2010.06633.x)
Watkins, A. J. et al., 2010. Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring. British Journal of Nutrition 103 (12), pp.1762-1770. (10.1017/S0007114509993783)

2009

Barkas, L. and Gray, W. P. 2009. Learning and memory impairment in chronic temporal lobe epilepsy [Conference Material]. Epilepsia 50 , pp.162-162.
Shtaya, A. , Pringle, A. and Gray, W. P. 2009. Kainate is both trophic and proliferative for hippocampal precursors via ampa receptors in vitro and has differential effects on proliferation kinetics in the subgranular zone and granule cell layer after seizure induction in vivo [Conference material]. Epilepsia 50 , pp.180-180.
Zaben, M. J. A. et al. 2009. The neurotransmitter VIP expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VPAC2 receptors or directs them toward a neuronal fate via VPAC1 receptors. Stem Cells 27 (10), pp.2539-2551. (10.1002/stem.184)

2008

Gray, W. P. 2008. Neuropeptide Y signalling on hippocampal stem cells in health and disease. Molecular and Cellular Endocrinology 288 (1-2), pp.52-62. (10.1016/j.mce.2008.02.021)
Gupta, D. , James, C. J. and Gray, W. P. 2008. Phase synchronization with ICA for epileptic seizure onset prediction in the long term EEG.. Presented at: 4th International Conference on Advances in Medical Signal and Information Processing Santa Margherita Ligure, Italy) 14-16 July 2008. Advances in Medical, Signal and Information Processing, 2008, MEDSIP 2008, 4th IET International Conference. Vol. 2008.IET Conference Publications Vol. CP540. Piscataway, NJ: IEEE(10.1049/cp:20080427)
Vajramani, G. et al., 2008. Bilingual aphasia due to spontaneous acute subdural haematoma from a ruptured intracranial infectious aneurysm. Clinical Neurology and Neurosurgery 110 (8), pp.823-827. (10.1016/j.clineuro.2008.05.008)
Watkins, A. et al., 2008. Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring. Journal of Physiology 586 (8), pp.2231-2244. (10.1113/jphysiol.2007.149229)

2007

Laskowski, A. et al., 2007. NPY mediates basal and seizure-induced proliferation in the subcallosal zone. NeuroReport 18 (10), pp.1005-1008. (10.1097/WNR.0b013e32815277ab)
Howell, O. W. et al., 2007. Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus. Neurobiology of Disease 26 (1), pp.174-188. (http://dx.doi.org/10.1016/j.nbd.2006.12.014)
Scharfman, H. E. and Gray, W. P. 2007. Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy. Epilepsia 48 (s2), pp.33-41. (10.1111/j.1528-1167.2007.01065.x)

2006

Sadgrove, M. P. , Laskowski, A. and Gray, W. P. 2006. Examination of granule layer cell count, cell density, and single-pulse brdu incorporation in rat organotypic hippocampal slice cultures with respect to culture medium, septotemporal position, and time in vitro. The Journal of Comparative Neurology 497 (3), pp.397. (10.1002/cne.21000)
Scharfman, H. E. and Gray, W. P. 2006. Plasticity of neuropeptide Y in the dentate gyrus after seizures, and its relevance to seizure-induced neurogenesis. Exs -Basel- 95 , pp.193-211. (10.1007/3-7643-7417-9_15)

2005

Vajramani, G. V. et al., 2005. Persistent and intractable ventriculitis due to retained ventricular catheters.. British Journal of Neurosurgery 19 (6), pp.496-501. (10.1080/02688690500495299)
Walker, M. et al., 2005. Nonconvulsive status epilepticus: Epilepsy Research Foundation workshop reports. Epileptic Disorders 7 (3), pp.253-296.
Howell, O. W. et al., 2005. Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. Journal of Neurochemistry 93 (3), pp.560-570. (10.1111/j.1471-4159.2005.03057.x)
Sadgrove, M. P. , Chad, J. E. and Gray, W. P. 2005. Kainic acid induces rapid cell death followed by transiently reduced cell proliferation in the immature granule cell layer of rat organotypic hippocampal slice cultures. Brain Research 1035 (2), pp.111-119.

2003

Howell, O. W. et al., 2003. Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. Journal of Neuroscience 86 (3), pp.646-659. (10.1046/j.1471-4159.2003.01895.x)
Huttmann, K. et al., 2003. Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis. European Journal of Neuroscience 18 (10), pp.2769-2778. (10.1111/j.1460-9568.2003.03002.x)

2002

Gray, W. P. , May, K. and Sundström, L. E. 2002. Seizure induced dentate neurogenesis does not diminish with age in rats. Neuroscience Letters 330 (3), pp.235-238. (10.1016/S0304-3940(02)00810-8)

1999

Hinterkeuser, S. et al., 1999. Characterization of astrocytic proliferation in rat dentate gyrus. Journal of Neurochemistry 73 , pp.S70-S70.
Parent, J. M. , Gage, F. H. and Gray, W. P. 1999. Altered postnatal neurogenesis as a form of seizure-induced brain plasticity. Epilepsia 40 , pp.1-1.

1998

Gray, W. P. and Sundstrom, L. E. 1998. Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat. Brain Research 790 (1-2), pp.52-59. (10.1016/S0006-8993(98)00030-4)
Gray, W. P. , Somers, J. and Buckley, T. F. 1998. Report of a national neurosurgical emergency teleconsulting system. Neurosurgery 42 (1), pp.103-107. (10.1097/00006123-199801000-00020)

1997

Gray, W. P. , Keohane, C. and Kirwan, W. O. 1997. Motor nerve transplantation. Journal of Neurosurgery 87 (4), pp.615-624. (10.3171/jns.1997.87.4.0615)
Gray, W. P. et al. 1997. Benefits and pitfalls of telemedicine in neurosurgery. Journal of Telemedicine and Telecare 3 (2), pp.108-110. (10.1258/1357633971930959)
Gray, W. P. , Somers, J. and Buckley, T. F. 1997. Report of a national neurosurgical teleradiology system. Journal of Telemedicine and Telecare 3 (1), pp.36-37. (10.1258/1357633961929718)

1996

Gray, W. P. et al. 1996. A clinical study of parenchymal and subdural miniature strain-gauge transducers for monitoring intracranial pressure. Neurosurgery 39 (5), pp.927-931. (10.1097/00006123-199711000-00051)

1990

O'Sullivan, M. G. J. , Gray, W. P. and Buckley, T. F. 1990. Extradural haematoma in the Irish Republic: An analysis of 82 cases with emphasis on 'delay'. British Journal of Surgery 77 (12), pp.1391-1394. (10.1002/bjs.1800771223)
O'sullivan, M. G. , Gray, W. P. and Buckley, T. F. 1990. Non-neurosurgical operative intervention in head-injured patients. British Journal of Neurosurgery 4 (6), pp.473-478. (10.3109/02688699008993795)

Human Brain Tissue & CSF for Translational Research

Tissue obtained from Brain Surgery- Excess tissue removed is used for research

Epilepsy Surgery
Tumour Surgery
Head injury surgery

Culturing Human Brain tissue in 3D

Ex vivo human tissue
3D culture
Heterogeneity
High Density
Air-liquid interface
Semi-permeable membrane insert

We use cultures of human brain to study how the brain works and what goes wrong in disease

Collaboration with Dr F Siebzehnrubl, Dr M Zaben & Prof W Gray

We are using brain tissue to assess the effectiveness of cell transplantation for brain repair

Collaboration with Dr Y Zhu, Dr A Errington, Prof Meng Li & Prof W Gray.

Early Diagnoses of Brain Infection

Using Cerebrospinal Fluid (CSF) samples from patients with suspected infection we are examining the use of immune markers to accurately diagnose infection much earlier than with standard micriobiology cultures and so treat patients earlier.

Collab with Prof M Ebryl, Dr S Cuff, Dr J Merola & Prof W Gray.

(Refer to Images 1, 2 and 3 in right hand menu)*