![William Gray](https://profiles-cardiff.imgix.net/attachments/1033?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro William Gray
Professor of Functional Neurosurgery, Neurosciences & Mental Health Research Institute
Trosolwyg
Fi yw cyfarwyddwr Uned BRAIN a ariennir gan Ymchwil Iechyd a Gofal Cymru ac yn Athro Niwrolawdriniaeth. Rwy'n gwneud ymchwil glinigol mewn epilepsi, yr hipocampws, dysgu a'r cof.
Mae fy ymchwil yn cynnwys delweddu cleifion epilepsi i ddeall tarddiad trawiad a chamweithrediad gwybyddol, recordiadau EEG mewnwranol, delweddu ffrydiau ffibr mater gwyn, strwythur mater llwyd delweddu, microstrwythur a fMRI.
Cyhoeddiad
2023
- Ferreira-Atuesta, C. et al. 2023. Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults. Brain 146(6), pp. 2389–2398. (10.1093/brain/awac437)
- Brown, J. et al. 2023. A high-density 3-dimensional culture model of human glioblastoma for rapid screening of therapeutic resistance. Biochemical Pharmacology 208, article number: 115410. (10.1016/j.bcp.2023.115410)
2022
- Shastin, D. et al. 2022. Surface-based tracking for short association fibre tractography. NeuroImage 260, article number: 119423. (10.1016/j.neuroimage.2022.119423)
- Cuff, S. M., Merola, J. P., Eberl, M. and Gray, W. P. 2022. Presence of ventriculoperitoneal and lumbar shunts stimulate long lasting non-inflammatory changes in the cerebrospinal fluid distinct from the response to bacterial infection. [Online]. medRxiv. (10.1101/2022.10.12.22280998) Available at: https://doi.org/10.1101/2022.10.12.22280998
- Sanders, B. et al. 2022. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nature Communications 13(1), article number: 27. (10.1038/s41467-021-27601-0)
2021
- Bartley, O. J. M., Lelos, M. J., Gray, W. P. and Rosser, A. E. 2021. Do foetal transplant studies continue to be justified in Huntington's disease?. Neuronal Signaling 5, article number: acerbic. (10.1042/NS20210019)
- Chamberland, M. et al. 2021. Detecting microstructural deviations in individuals with deep diffusion MRI tractometry. Nature Computational Science 1, pp. 598-606. (10.1038/s43588-021-00126-8)
- Zaben, M., Haan, N., Sharouf, F., Ahmed, A., Sundstrom, L. E. and Gray, W. P. 2021. IL-1β and HMGB1 are anti-neurogenic to endogenous neural stem cells in the sclerotic epileptic human hippocampus. Journal of Neuroinflammation 18(1), article number: 218. (10.1186/s12974-021-02265-1)
- Haan, N., Westacott, L. J., Carter, J., Owen, M. J., Gray, W. P., Hall, J. and Wilkinson, L. S. 2021. Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms. Translational Psychiatry 11(1), article number: 313. (10.1038/s41398-021-01415-6)
- Rosser, A. E. et al. 2021. Cell therapy for Huntington's disease: learning from failure. Movement Disorders 36(3), pp. 787-788. (10.1002/mds.28503)
- Ved, R. et al. 2021. Disulfide HMGB1 acts via TLR2/4 receptors to reduce the numbers of oligodendrocyte progenitor cells after traumatic injury in vitro. Scientific Reports 11, article number: 6181. (10.1038/s41598-021-84932-0)
- Badin, R. A. et al. 2021. Stem cells for Huntington’s disease (SC4HD): an international consortium to facilitate stem cell-based therapy for Huntington’s disease. Journal of Huntington's Disease 10(2), pp. 221-226. (10.3233/JHD-210473)
2020
- Cuff, S. M., Merola, J. P., Twohig, J. P., Eberl, M. and Gray, W. P. 2020. Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation. Brain Communications 2(2), article number: fcaa218. (10.1093/braincomms/fcaa218)
- Manivannan, S. et al. 2020. Glycyrrhizin blocks the detrimental effects of HMGB1 on cortical neurogenesis after traumatic neuronal injury. Brain Sciences 10(10), article number: 760. (10.3390/brainsci10100760)
- Postans, M. et al. 2020. Uncovering a role for the dorsal hippocampal commissure in recognition memory. Cerebral Cortex 30(3), pp. 1001-1015. (10.1093/cercor/bhz143)
2019
- Drew, C. J. G. et al. 2019. A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial). Pilot and Feasibility Studies 5(1), article number: 87. (10.1186/s40814-019-0474-x)
2018
- Messaritaki, E., Umesh, R. S., Parker, G., Gray, W. and Jones, D. 2018. Improving the predictions of computational models of convection-enhanced drug delivery by accounting for diffusion non-Gaussianity. Frontiers in Neurology 9, article number: 1092. (10.3389/fneur.2018.01092)
2017
- Jamjoom, A. A. B. et al. 2017. Prospective, multicentre study of external ventricular drainage-related infections in the UK and Ireland. Journal of Neurology, Neurosurgery & Psychiatry (10.1136/jnnp-2017-316415)
- Chamberland, M., Gray, W., Descoteaux, M. and Jones, D. 2017. Interactive computation and visualization of structural connectomes in real-time. Presented at: CNI 2017: International Workshop on Connectomics in Neuroimaging, Quebec City, QC, Canada, 14 September 2017 Presented at Wu, G. et al. eds.Connectomics in NeuroImaging, Vol. 10511. Lecture Notes in Computer Science Cham, Switzerland: Springer Verlag pp. 35-41., (10.1007/978-3-319-67159-8_5)
2016
- Hamandi, K., Robson, S. E., Zaben, M., Singh, K. D. and Gray, W. P. 2016. Retinotopic fMRI and tumour resection in a case with occipital lobe epilepsy. Seizure - European Journal of Epilepsy 41, pp. 175-178. (10.1016/j.seizure.2016.08.006)
- Lidster, K. et al. 2016. Opportunities for improving animal welfare in rodent models of epilepsy and seizures. Journal of Neuroscience Methods 260, pp. 2-25. (10.1016/j.jneumeth.2015.09.007)
2015
- Jamjoom, A. A. B. et al. 2015. External ventricular drainage: Is it time to look at national practice?. British Journal of Neurosurgery, pp. 1. (10.3109/02688697.2014.957162)
2013
- Zaben, M. J. A. and Gray, W. P. 2013. Neuropeptides and hippocampal neurogenesis. Neuropeptides 47(6), pp. 431-438. (10.1016/j.npep.2013.10.002)
- Howell, O. W. et al. 2013. Corrigendum to 'Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus' [Neurobiol. Dis. 26/1 (2007) 174?188]. Neurobiology of Disease 49, pp. 199. (10.1016/j.nbd.2012.06.006)
2012
- Cheung, A., Newland, P. L., Zaben, M. J. A., Attard, G. S. and Gray, W. P. 2012. Intracellular nitric oxide mediates neuroproliferative effect of neuropeptide Y on postnatal hippocampal precursor cells. Journal of Biological Chemistry 287(24), pp. 20187-20196. (10.1074/jbc.M112.346783)
- Ahmed, A. I., Shtaya, A. B., Zaben, M. J. A., Owens, E. V., Kiecker, C. and Gray, W. P. 2012. Endogenous GFAP-positive neural stem/progenitor cells in the postnatal mouse cortex are activated following traumatic brain injury. Journal of Neurotrauma 29(5), pp. 828-842. (10.1089/neu.2011.1923)
2011
- Abbosh, C., Lawkowski, A., Zaben, M. J. A. and Gray, W. P. 2011. GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors. Journal of Neurochemistry 117(3), pp. 425-436. (10.1111/j.1471-4159.2011.07204.x)
- Ahmed, A., Zaben, M. J. A. and Gray, W. P. 2011. Stem cells in the adult human brain. British Journal of Neurosurgery 25(1), pp. 28-37. (10.3109/02688697.2010.525264)
2010
- Rodrigo, C., Zaben, M. J. A., Lawrence, T., Laskowski, A., Howell, O. and Gray, W. P. 2010. NPY augments the proliferative effect of FGF2 and increases the expression of FGFR1 on nestin positive postnatal hippocampal precursor cells, via the Y1 receptor. Journal of Neurochemistry 113(3), pp. 615-627. (10.1111/j.1471-4159.2010.06633.x)
2009
- Zaben, M. J. A., Sheward, W. J., Shtaya, A., Abbosh, C., Harmar, A. J., Pringle, A. K. and Gray, W. P. 2009. The neurotransmitter VIP expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VPAC2 receptors or directs them toward a neuronal fate via VPAC1 receptors. Stem Cells 27(10), pp. 2539-2551. (10.1002/stem.184)
2008
- Gupta, D., James, C. J. and Gray, W. P. 2008. Phase synchronization with ICA for epileptic seizure onset prediction in the long term EEG.. Presented at: 4th International Conference on Advances in Medical Signal and Information Processing, Santa Margherita Ligure, Italy), 14-16 July 2008Advances in Medical, Signal and Information Processing, 2008, MEDSIP 2008, 4th IET International Conference, Vol. 2008. IET Conference Publications Vol. CP540. Piscataway, NJ: IEEE, (10.1049/cp:20080427)
2007
- Howell, O. W. et al. 2007. Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus. Neurobiology of Disease 26(1), pp. 174-188. (http://dx.doi.org/10.1016/j.nbd.2006.12.014)
Cynadleddau
- Chamberland, M., Gray, W., Descoteaux, M. and Jones, D. 2017. Interactive computation and visualization of structural connectomes in real-time. Presented at: CNI 2017: International Workshop on Connectomics in Neuroimaging, Quebec City, QC, Canada, 14 September 2017 Presented at Wu, G. et al. eds.Connectomics in NeuroImaging, Vol. 10511. Lecture Notes in Computer Science Cham, Switzerland: Springer Verlag pp. 35-41., (10.1007/978-3-319-67159-8_5)
- Gupta, D., James, C. J. and Gray, W. P. 2008. Phase synchronization with ICA for epileptic seizure onset prediction in the long term EEG.. Presented at: 4th International Conference on Advances in Medical Signal and Information Processing, Santa Margherita Ligure, Italy), 14-16 July 2008Advances in Medical, Signal and Information Processing, 2008, MEDSIP 2008, 4th IET International Conference, Vol. 2008. IET Conference Publications Vol. CP540. Piscataway, NJ: IEEE, (10.1049/cp:20080427)
Erthyglau
- Ferreira-Atuesta, C. et al. 2023. Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults. Brain 146(6), pp. 2389–2398. (10.1093/brain/awac437)
- Brown, J. et al. 2023. A high-density 3-dimensional culture model of human glioblastoma for rapid screening of therapeutic resistance. Biochemical Pharmacology 208, article number: 115410. (10.1016/j.bcp.2023.115410)
- Shastin, D. et al. 2022. Surface-based tracking for short association fibre tractography. NeuroImage 260, article number: 119423. (10.1016/j.neuroimage.2022.119423)
- Sanders, B. et al. 2022. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nature Communications 13(1), article number: 27. (10.1038/s41467-021-27601-0)
- Bartley, O. J. M., Lelos, M. J., Gray, W. P. and Rosser, A. E. 2021. Do foetal transplant studies continue to be justified in Huntington's disease?. Neuronal Signaling 5, article number: acerbic. (10.1042/NS20210019)
- Chamberland, M. et al. 2021. Detecting microstructural deviations in individuals with deep diffusion MRI tractometry. Nature Computational Science 1, pp. 598-606. (10.1038/s43588-021-00126-8)
- Zaben, M., Haan, N., Sharouf, F., Ahmed, A., Sundstrom, L. E. and Gray, W. P. 2021. IL-1β and HMGB1 are anti-neurogenic to endogenous neural stem cells in the sclerotic epileptic human hippocampus. Journal of Neuroinflammation 18(1), article number: 218. (10.1186/s12974-021-02265-1)
- Haan, N., Westacott, L. J., Carter, J., Owen, M. J., Gray, W. P., Hall, J. and Wilkinson, L. S. 2021. Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms. Translational Psychiatry 11(1), article number: 313. (10.1038/s41398-021-01415-6)
- Rosser, A. E. et al. 2021. Cell therapy for Huntington's disease: learning from failure. Movement Disorders 36(3), pp. 787-788. (10.1002/mds.28503)
- Ved, R. et al. 2021. Disulfide HMGB1 acts via TLR2/4 receptors to reduce the numbers of oligodendrocyte progenitor cells after traumatic injury in vitro. Scientific Reports 11, article number: 6181. (10.1038/s41598-021-84932-0)
- Badin, R. A. et al. 2021. Stem cells for Huntington’s disease (SC4HD): an international consortium to facilitate stem cell-based therapy for Huntington’s disease. Journal of Huntington's Disease 10(2), pp. 221-226. (10.3233/JHD-210473)
- Cuff, S. M., Merola, J. P., Twohig, J. P., Eberl, M. and Gray, W. P. 2020. Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation. Brain Communications 2(2), article number: fcaa218. (10.1093/braincomms/fcaa218)
- Manivannan, S. et al. 2020. Glycyrrhizin blocks the detrimental effects of HMGB1 on cortical neurogenesis after traumatic neuronal injury. Brain Sciences 10(10), article number: 760. (10.3390/brainsci10100760)
- Postans, M. et al. 2020. Uncovering a role for the dorsal hippocampal commissure in recognition memory. Cerebral Cortex 30(3), pp. 1001-1015. (10.1093/cercor/bhz143)
- Drew, C. J. G. et al. 2019. A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial). Pilot and Feasibility Studies 5(1), article number: 87. (10.1186/s40814-019-0474-x)
- Messaritaki, E., Umesh, R. S., Parker, G., Gray, W. and Jones, D. 2018. Improving the predictions of computational models of convection-enhanced drug delivery by accounting for diffusion non-Gaussianity. Frontiers in Neurology 9, article number: 1092. (10.3389/fneur.2018.01092)
- Jamjoom, A. A. B. et al. 2017. Prospective, multicentre study of external ventricular drainage-related infections in the UK and Ireland. Journal of Neurology, Neurosurgery & Psychiatry (10.1136/jnnp-2017-316415)
- Hamandi, K., Robson, S. E., Zaben, M., Singh, K. D. and Gray, W. P. 2016. Retinotopic fMRI and tumour resection in a case with occipital lobe epilepsy. Seizure - European Journal of Epilepsy 41, pp. 175-178. (10.1016/j.seizure.2016.08.006)
- Lidster, K. et al. 2016. Opportunities for improving animal welfare in rodent models of epilepsy and seizures. Journal of Neuroscience Methods 260, pp. 2-25. (10.1016/j.jneumeth.2015.09.007)
- Jamjoom, A. A. B. et al. 2015. External ventricular drainage: Is it time to look at national practice?. British Journal of Neurosurgery, pp. 1. (10.3109/02688697.2014.957162)
- Zaben, M. J. A. and Gray, W. P. 2013. Neuropeptides and hippocampal neurogenesis. Neuropeptides 47(6), pp. 431-438. (10.1016/j.npep.2013.10.002)
- Howell, O. W. et al. 2013. Corrigendum to 'Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus' [Neurobiol. Dis. 26/1 (2007) 174?188]. Neurobiology of Disease 49, pp. 199. (10.1016/j.nbd.2012.06.006)
- Cheung, A., Newland, P. L., Zaben, M. J. A., Attard, G. S. and Gray, W. P. 2012. Intracellular nitric oxide mediates neuroproliferative effect of neuropeptide Y on postnatal hippocampal precursor cells. Journal of Biological Chemistry 287(24), pp. 20187-20196. (10.1074/jbc.M112.346783)
- Ahmed, A. I., Shtaya, A. B., Zaben, M. J. A., Owens, E. V., Kiecker, C. and Gray, W. P. 2012. Endogenous GFAP-positive neural stem/progenitor cells in the postnatal mouse cortex are activated following traumatic brain injury. Journal of Neurotrauma 29(5), pp. 828-842. (10.1089/neu.2011.1923)
- Abbosh, C., Lawkowski, A., Zaben, M. J. A. and Gray, W. P. 2011. GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors. Journal of Neurochemistry 117(3), pp. 425-436. (10.1111/j.1471-4159.2011.07204.x)
- Ahmed, A., Zaben, M. J. A. and Gray, W. P. 2011. Stem cells in the adult human brain. British Journal of Neurosurgery 25(1), pp. 28-37. (10.3109/02688697.2010.525264)
- Rodrigo, C., Zaben, M. J. A., Lawrence, T., Laskowski, A., Howell, O. and Gray, W. P. 2010. NPY augments the proliferative effect of FGF2 and increases the expression of FGFR1 on nestin positive postnatal hippocampal precursor cells, via the Y1 receptor. Journal of Neurochemistry 113(3), pp. 615-627. (10.1111/j.1471-4159.2010.06633.x)
- Zaben, M. J. A., Sheward, W. J., Shtaya, A., Abbosh, C., Harmar, A. J., Pringle, A. K. and Gray, W. P. 2009. The neurotransmitter VIP expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VPAC2 receptors or directs them toward a neuronal fate via VPAC1 receptors. Stem Cells 27(10), pp. 2539-2551. (10.1002/stem.184)
- Howell, O. W. et al. 2007. Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus. Neurobiology of Disease 26(1), pp. 174-188. (http://dx.doi.org/10.1016/j.nbd.2006.12.014)
Gwefannau
- Cuff, S. M., Merola, J. P., Eberl, M. and Gray, W. P. 2022. Presence of ventriculoperitoneal and lumbar shunts stimulate long lasting non-inflammatory changes in the cerebrospinal fluid distinct from the response to bacterial infection. [Online]. medRxiv. (10.1101/2022.10.12.22280998) Available at: https://doi.org/10.1101/2022.10.12.22280998
Ymchwil
Human Brain Tissue & CSF for Translational Research
Tissue obtained from Brain Surgery- Excess tissue removed is used for research
- Epilepsy Surgery
- Tumour Surgery
- Head injury surgery
Culturing Human Brain tissue in 3D
- Ex vivo human tissue
- 3D culture
- Heterogeneity
- High Density
- Air-liquid interface
- Semi-permeable membrane insert
We use cultures of human brain to study how the brain works and what goes wrong in disease
Collaboration with Dr F Siebzehnrubl, Dr M Zaben & Prof W Gray
We are using brain tissue to assess the effectiveness of cell transplantation for brain repair
Collaboration with Dr Y Zhu, Dr A Errington, Prof Meng Li & Prof W Gray.
Early Diagnoses of Brain Infection
Using Cerebrospinal Fluid (CSF) samples from patients with suspected infection we are examining the use of immune markers to accurately diagnose infection much earlier than with standard micriobiology cultures and so treat patients earlier.
Collab with Prof M Ebryl, Dr S Cuff, Dr J Merola & Prof W Gray.
(Refer to Images 1, 2 and 3 in right hand menu)*
Contact Details
GrayWP@caerdydd.ac.uk
+44 29206 88491
Prif Adeilad yr Ysbyty, Ystafell 3.33, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
+44 29206 88491
Prif Adeilad yr Ysbyty, Ystafell 3.33, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
