Dr Josephine Haddon
PhD Cardiff
Timau a rolau for Josephine Haddon
Cydymaith Ymchwil
Trosolwyg
Crynodeb o'r ymchwil
Mae fy ymchwil wedi cynnwys ymchwilio i ffactorau sy'n dylanwadu ar swyddogaeth yr ymennydd mewn iechyd a chlefydau. Er mwyn cyflawni hyn, rwyf wedi cynnal astudiaethau gyda phoblogaethau clinigol, yn ogystal â modelau cellog anifeiliaid a dynol.
Prosiectau ymchwil
2024 - presennol: Y Ditectifs Cwsg: Haeniad cwsg mewn pobl ifanc sydd â risg uchel o seicosis (Wellcome Trust)
Cyhoeddiad
2026
- Wilkinson, G. et al. 2026. CACNA1C genetic variants differentially affect neuronal networks through divergent pathways. Biological Psychiatry Global Open Science 100792. (10.1016/j.bpsgos.2026.100792)
- Clayton, J. P. et al., 2026. Public involvement and co-design of longitudinal studies of sleep health alongside young people with rare genetic conditions. Research Involvement and Engagement 12 (1) 113. (10.1186/s40900-026-00935-z)
- Alsaqati, M. et al. 2026. Effects of acute fluctuations of extracellular Zinc on network activity of human iPSC-derived neurons; impact of NMDA Receptor and L-Type Calcium Channel Activation. Neuropharmacology 292 110952. (10.1016/j.neuropharm.2026.110952)
- Saka, A. et al., 2026. The Sleep Detectives: a co-designed protocol for longitudinal tracking of sleep health, sleep neurophysiology and cognition in children and young people at risk of neurodevelopmental disorders [Abstract]. Sleep Medicine 138 106934. (10.1016/j.sleep.2025.106934)
2024
- George, D. N. , Haddon, J. E. and Griffiths, O. 2024. Absence of differential protection from extinction in human causal learning.. Journal of Experimental Psychology: Animal Learning and Cognition 50 (3), pp.161-185. (10.1037/xan0000380)
- Haddon, J. E. et al. 2024. Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility. Translational Psychiatry 14 (1) 256. (10.1038/s41398-024-02969-x)
2023
- George, D. N. , Killcross, S. and Haddon, J. E. 2023. Competing contextual processes rely on the infralimbic and prelimbic medial prefrontal cortices in the rat. Oxford Open Neuroscience 2 kvad003. (10.1093/oons/kvad003)
2021
- George, D. N. and Haddon, J. E. 2021. Preexposure along a continuum: differentiation and association.. Journal of Experimental Psychology: Animal Learning and Cognition 47 (1), pp.48-62. (10.1037/xan0000266)
2019
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45 (5), pp.1024-1032. (10.1093/schbul/sby146)
- Silva, A. I. et al., 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10 3455. (10.1038/s41467-019-11119-7)
2014
- Haddon, J. E. et al. 2014. Extreme elemental processing in a high schizotypy population: relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 67 (5), pp.918-935. (10.1080/17470218.2013.838281)
- Nelson, A. J. D. et al. 2014. A novel role for the rat retrosplenial cortex in cognitive control. Learning and Memory 21 (2), pp.90-97. (10.1101/lm.032136.113)
2013
- Cohen, S. R. et al. 2013. Pavlovian-to-instrumental transfer: paradoxical effects of the Pavlovian relationship explained. Journal of Experimental Psychology: Animal Behavior Processes 39 (1), pp.14-23. (10.1037/a0030594)
2011
- Haddon, J. E. et al. 2011. Impaired conditional task performance in a high schizotypy population: Relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 64 (1), pp.1-9. (10.1080/17470218.2010.529579)
- Haddon, J. E. and Killcross, A. S. 2011. Inactivation of the infralimbic prefrontal cortex in rats reduces the influence of inappropriate habitual responding in a response-conflict task. Neuroscience 199 , pp.205-212. (10.1016/j.neuroscience.2011.09.065)
2008
- Haddon, J. E. , George, D. N. and Killcross, A. S. 2008. Contextual control of biconditional task performance: Evidence for cue and response competition in rats. The Quarterly Journal of Experimental Psychology 61 (9), pp.1307-1320. (10.1080/17470210701515819)
2007
- Haddon, J. E. and Killcross, A. S. 2007. Contextual Control of Choice Performance: Behavioral, Neurobiological, and Neurochemical Influences. Annals of the New York Academy of Sciences 1104 (1), pp.250-269. (10.1196/annals.1390.000)
- Marquis, J. , Killcross, A. S. and Haddon, J. E. 2007. Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats. European Journal of Neuroscience 25 (2), pp.559-566. (10.1111/j.1460-9568.2006.05295.x)
2006
- Haddon, J. E. and Killcross, A. S. 2006. Prefrontal cortex lesions disrupt the contextual control of response conflict. Journal of Neuroscience 26 (11), pp.2933-2940. (10.1523/JNEUROSCI.3243-05.2006)
- Haddon, J. E. 2006. Response conflict, prefrontal cortex and dopamine: a rat model of Stroop-like performance. British Neuroscience Association Bulletin (54), pp.18-20.
- Haddon, J. E. and Killcross, A. S. 2006. Both motivational and training factors affect response conflict choice performance in rats. Neural Networks 19 (8), pp.1192-1202. (10.1016/j.neunet.2006.04.004)
2005
- Haddon, J. E. and Killcross, A. S. 2005. Medial Prefrontal Cortex Lesions Abolish Contextual Control of Competing Responses. Journal of the Experimental Analysis of Behavior 84 (3), pp.485-504. (10.1901/jeab.2005.81-04)
Erthyglau
- Wilkinson, G. et al. 2026. CACNA1C genetic variants differentially affect neuronal networks through divergent pathways. Biological Psychiatry Global Open Science 100792. (10.1016/j.bpsgos.2026.100792)
- Clayton, J. P. et al., 2026. Public involvement and co-design of longitudinal studies of sleep health alongside young people with rare genetic conditions. Research Involvement and Engagement 12 (1) 113. (10.1186/s40900-026-00935-z)
- Alsaqati, M. et al. 2026. Effects of acute fluctuations of extracellular Zinc on network activity of human iPSC-derived neurons; impact of NMDA Receptor and L-Type Calcium Channel Activation. Neuropharmacology 292 110952. (10.1016/j.neuropharm.2026.110952)
- Saka, A. et al., 2026. The Sleep Detectives: a co-designed protocol for longitudinal tracking of sleep health, sleep neurophysiology and cognition in children and young people at risk of neurodevelopmental disorders [Abstract]. Sleep Medicine 138 106934. (10.1016/j.sleep.2025.106934)
- George, D. N. , Haddon, J. E. and Griffiths, O. 2024. Absence of differential protection from extinction in human causal learning.. Journal of Experimental Psychology: Animal Learning and Cognition 50 (3), pp.161-185. (10.1037/xan0000380)
- Haddon, J. E. et al. 2024. Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility. Translational Psychiatry 14 (1) 256. (10.1038/s41398-024-02969-x)
- George, D. N. , Killcross, S. and Haddon, J. E. 2023. Competing contextual processes rely on the infralimbic and prelimbic medial prefrontal cortices in the rat. Oxford Open Neuroscience 2 kvad003. (10.1093/oons/kvad003)
- George, D. N. and Haddon, J. E. 2021. Preexposure along a continuum: differentiation and association.. Journal of Experimental Psychology: Animal Learning and Cognition 47 (1), pp.48-62. (10.1037/xan0000266)
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45 (5), pp.1024-1032. (10.1093/schbul/sby146)
- Silva, A. I. et al., 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10 3455. (10.1038/s41467-019-11119-7)
- Haddon, J. E. et al. 2014. Extreme elemental processing in a high schizotypy population: relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 67 (5), pp.918-935. (10.1080/17470218.2013.838281)
- Nelson, A. J. D. et al. 2014. A novel role for the rat retrosplenial cortex in cognitive control. Learning and Memory 21 (2), pp.90-97. (10.1101/lm.032136.113)
- Cohen, S. R. et al. 2013. Pavlovian-to-instrumental transfer: paradoxical effects of the Pavlovian relationship explained. Journal of Experimental Psychology: Animal Behavior Processes 39 (1), pp.14-23. (10.1037/a0030594)
- Haddon, J. E. et al. 2011. Impaired conditional task performance in a high schizotypy population: Relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 64 (1), pp.1-9. (10.1080/17470218.2010.529579)
- Haddon, J. E. and Killcross, A. S. 2011. Inactivation of the infralimbic prefrontal cortex in rats reduces the influence of inappropriate habitual responding in a response-conflict task. Neuroscience 199 , pp.205-212. (10.1016/j.neuroscience.2011.09.065)
- Haddon, J. E. , George, D. N. and Killcross, A. S. 2008. Contextual control of biconditional task performance: Evidence for cue and response competition in rats. The Quarterly Journal of Experimental Psychology 61 (9), pp.1307-1320. (10.1080/17470210701515819)
- Haddon, J. E. and Killcross, A. S. 2007. Contextual Control of Choice Performance: Behavioral, Neurobiological, and Neurochemical Influences. Annals of the New York Academy of Sciences 1104 (1), pp.250-269. (10.1196/annals.1390.000)
- Marquis, J. , Killcross, A. S. and Haddon, J. E. 2007. Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats. European Journal of Neuroscience 25 (2), pp.559-566. (10.1111/j.1460-9568.2006.05295.x)
- Haddon, J. E. and Killcross, A. S. 2006. Prefrontal cortex lesions disrupt the contextual control of response conflict. Journal of Neuroscience 26 (11), pp.2933-2940. (10.1523/JNEUROSCI.3243-05.2006)
- Haddon, J. E. 2006. Response conflict, prefrontal cortex and dopamine: a rat model of Stroop-like performance. British Neuroscience Association Bulletin (54), pp.18-20.
- Haddon, J. E. and Killcross, A. S. 2006. Both motivational and training factors affect response conflict choice performance in rats. Neural Networks 19 (8), pp.1192-1202. (10.1016/j.neunet.2006.04.004)
- Haddon, J. E. and Killcross, A. S. 2005. Medial Prefrontal Cortex Lesions Abolish Contextual Control of Competing Responses. Journal of the Experimental Analysis of Behavior 84 (3), pp.485-504. (10.1901/jeab.2005.81-04)