Dr Josephine Haddon
PhD Cardiff
Teams and roles for Josephine Haddon
Research Associate
Overview
Research summary
My research has involved investigating factors that influence brain function in health and disease. To achieve this, I have conducted studies with clinical populations, as well as animal and human cellular models.
Research projects
2024 - present: The Sleep Detectives: Sleep stratification in young people at high risk of psychosis (Wellcome Trust)
Publication
2026
- Wilkinson, G. et al. 2026. CACNA1C genetic variants differentially affect neuronal networks through divergent pathways. Biological Psychiatry Global Open Science 100792. (10.1016/j.bpsgos.2026.100792)
- Clayton, J. P. et al., 2026. Public involvement and co-design of longitudinal studies of sleep health alongside young people with rare genetic conditions. Research Involvement and Engagement 12 (1) 113. (10.1186/s40900-026-00935-z)
- Alsaqati, M. et al. 2026. Effects of acute fluctuations of extracellular Zinc on network activity of human iPSC-derived neurons; impact of NMDA Receptor and L-Type Calcium Channel Activation. Neuropharmacology 292 110952. (10.1016/j.neuropharm.2026.110952)
- Saka, A. et al., 2026. The Sleep Detectives: a co-designed protocol for longitudinal tracking of sleep health, sleep neurophysiology and cognition in children and young people at risk of neurodevelopmental disorders [Abstract]. Sleep Medicine 138 106934. (10.1016/j.sleep.2025.106934)
2024
- George, D. N. , Haddon, J. E. and Griffiths, O. 2024. Absence of differential protection from extinction in human causal learning.. Journal of Experimental Psychology: Animal Learning and Cognition 50 (3), pp.161-185. (10.1037/xan0000380)
- Haddon, J. E. et al. 2024. Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility. Translational Psychiatry 14 (1) 256. (10.1038/s41398-024-02969-x)
2023
- George, D. N. , Killcross, S. and Haddon, J. E. 2023. Competing contextual processes rely on the infralimbic and prelimbic medial prefrontal cortices in the rat. Oxford Open Neuroscience 2 kvad003. (10.1093/oons/kvad003)
2021
- George, D. N. and Haddon, J. E. 2021. Preexposure along a continuum: differentiation and association.. Journal of Experimental Psychology: Animal Learning and Cognition 47 (1), pp.48-62. (10.1037/xan0000266)
2019
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45 (5), pp.1024-1032. (10.1093/schbul/sby146)
- Silva, A. I. et al., 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10 3455. (10.1038/s41467-019-11119-7)
2014
- Haddon, J. E. et al. 2014. Extreme elemental processing in a high schizotypy population: relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 67 (5), pp.918-935. (10.1080/17470218.2013.838281)
- Nelson, A. J. D. et al. 2014. A novel role for the rat retrosplenial cortex in cognitive control. Learning and Memory 21 (2), pp.90-97. (10.1101/lm.032136.113)
2013
- Cohen, S. R. et al. 2013. Pavlovian-to-instrumental transfer: paradoxical effects of the Pavlovian relationship explained. Journal of Experimental Psychology: Animal Behavior Processes 39 (1), pp.14-23. (10.1037/a0030594)
2011
- Haddon, J. E. et al. 2011. Impaired conditional task performance in a high schizotypy population: Relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 64 (1), pp.1-9. (10.1080/17470218.2010.529579)
- Haddon, J. E. and Killcross, A. S. 2011. Inactivation of the infralimbic prefrontal cortex in rats reduces the influence of inappropriate habitual responding in a response-conflict task. Neuroscience 199 , pp.205-212. (10.1016/j.neuroscience.2011.09.065)
2008
- Haddon, J. E. , George, D. N. and Killcross, A. S. 2008. Contextual control of biconditional task performance: Evidence for cue and response competition in rats. The Quarterly Journal of Experimental Psychology 61 (9), pp.1307-1320. (10.1080/17470210701515819)
2007
- Haddon, J. E. and Killcross, A. S. 2007. Contextual Control of Choice Performance: Behavioral, Neurobiological, and Neurochemical Influences. Annals of the New York Academy of Sciences 1104 (1), pp.250-269. (10.1196/annals.1390.000)
- Marquis, J. , Killcross, A. S. and Haddon, J. E. 2007. Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats. European Journal of Neuroscience 25 (2), pp.559-566. (10.1111/j.1460-9568.2006.05295.x)
2006
- Haddon, J. E. and Killcross, A. S. 2006. Prefrontal cortex lesions disrupt the contextual control of response conflict. Journal of Neuroscience 26 (11), pp.2933-2940. (10.1523/JNEUROSCI.3243-05.2006)
- Haddon, J. E. 2006. Response conflict, prefrontal cortex and dopamine: a rat model of Stroop-like performance. British Neuroscience Association Bulletin (54), pp.18-20.
- Haddon, J. E. and Killcross, A. S. 2006. Both motivational and training factors affect response conflict choice performance in rats. Neural Networks 19 (8), pp.1192-1202. (10.1016/j.neunet.2006.04.004)
2005
- Haddon, J. E. and Killcross, A. S. 2005. Medial Prefrontal Cortex Lesions Abolish Contextual Control of Competing Responses. Journal of the Experimental Analysis of Behavior 84 (3), pp.485-504. (10.1901/jeab.2005.81-04)
Articles
- Wilkinson, G. et al. 2026. CACNA1C genetic variants differentially affect neuronal networks through divergent pathways. Biological Psychiatry Global Open Science 100792. (10.1016/j.bpsgos.2026.100792)
- Clayton, J. P. et al., 2026. Public involvement and co-design of longitudinal studies of sleep health alongside young people with rare genetic conditions. Research Involvement and Engagement 12 (1) 113. (10.1186/s40900-026-00935-z)
- Alsaqati, M. et al. 2026. Effects of acute fluctuations of extracellular Zinc on network activity of human iPSC-derived neurons; impact of NMDA Receptor and L-Type Calcium Channel Activation. Neuropharmacology 292 110952. (10.1016/j.neuropharm.2026.110952)
- Saka, A. et al., 2026. The Sleep Detectives: a co-designed protocol for longitudinal tracking of sleep health, sleep neurophysiology and cognition in children and young people at risk of neurodevelopmental disorders [Abstract]. Sleep Medicine 138 106934. (10.1016/j.sleep.2025.106934)
- George, D. N. , Haddon, J. E. and Griffiths, O. 2024. Absence of differential protection from extinction in human causal learning.. Journal of Experimental Psychology: Animal Learning and Cognition 50 (3), pp.161-185. (10.1037/xan0000380)
- Haddon, J. E. et al. 2024. Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility. Translational Psychiatry 14 (1) 256. (10.1038/s41398-024-02969-x)
- George, D. N. , Killcross, S. and Haddon, J. E. 2023. Competing contextual processes rely on the infralimbic and prelimbic medial prefrontal cortices in the rat. Oxford Open Neuroscience 2 kvad003. (10.1093/oons/kvad003)
- George, D. N. and Haddon, J. E. 2021. Preexposure along a continuum: differentiation and association.. Journal of Experimental Psychology: Animal Learning and Cognition 47 (1), pp.48-62. (10.1037/xan0000266)
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45 (5), pp.1024-1032. (10.1093/schbul/sby146)
- Silva, A. I. et al., 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10 3455. (10.1038/s41467-019-11119-7)
- Haddon, J. E. et al. 2014. Extreme elemental processing in a high schizotypy population: relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 67 (5), pp.918-935. (10.1080/17470218.2013.838281)
- Nelson, A. J. D. et al. 2014. A novel role for the rat retrosplenial cortex in cognitive control. Learning and Memory 21 (2), pp.90-97. (10.1101/lm.032136.113)
- Cohen, S. R. et al. 2013. Pavlovian-to-instrumental transfer: paradoxical effects of the Pavlovian relationship explained. Journal of Experimental Psychology: Animal Behavior Processes 39 (1), pp.14-23. (10.1037/a0030594)
- Haddon, J. E. et al. 2011. Impaired conditional task performance in a high schizotypy population: Relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 64 (1), pp.1-9. (10.1080/17470218.2010.529579)
- Haddon, J. E. and Killcross, A. S. 2011. Inactivation of the infralimbic prefrontal cortex in rats reduces the influence of inappropriate habitual responding in a response-conflict task. Neuroscience 199 , pp.205-212. (10.1016/j.neuroscience.2011.09.065)
- Haddon, J. E. , George, D. N. and Killcross, A. S. 2008. Contextual control of biconditional task performance: Evidence for cue and response competition in rats. The Quarterly Journal of Experimental Psychology 61 (9), pp.1307-1320. (10.1080/17470210701515819)
- Haddon, J. E. and Killcross, A. S. 2007. Contextual Control of Choice Performance: Behavioral, Neurobiological, and Neurochemical Influences. Annals of the New York Academy of Sciences 1104 (1), pp.250-269. (10.1196/annals.1390.000)
- Marquis, J. , Killcross, A. S. and Haddon, J. E. 2007. Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats. European Journal of Neuroscience 25 (2), pp.559-566. (10.1111/j.1460-9568.2006.05295.x)
- Haddon, J. E. and Killcross, A. S. 2006. Prefrontal cortex lesions disrupt the contextual control of response conflict. Journal of Neuroscience 26 (11), pp.2933-2940. (10.1523/JNEUROSCI.3243-05.2006)
- Haddon, J. E. 2006. Response conflict, prefrontal cortex and dopamine: a rat model of Stroop-like performance. British Neuroscience Association Bulletin (54), pp.18-20.
- Haddon, J. E. and Killcross, A. S. 2006. Both motivational and training factors affect response conflict choice performance in rats. Neural Networks 19 (8), pp.1192-1202. (10.1016/j.neunet.2006.04.004)
- Haddon, J. E. and Killcross, A. S. 2005. Medial Prefrontal Cortex Lesions Abolish Contextual Control of Competing Responses. Journal of the Experimental Analysis of Behavior 84 (3), pp.485-504. (10.1901/jeab.2005.81-04)