![Stephanie Hanna PhD, FHEA](https://profiles-cardiff.imgix.net/attachments/6109?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Stephanie Hanna
PhD, FHEA
Cymrawd Ymchwil
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Cymrawd Ymchwil a Sefydliad Lles Diabetes
Mae fy ymchwil yn canolbwyntio ar imiwnoleg diabetes math 1, gan ddefnyddio dulliau biowybodeg newydd i ddadansoddi ymatebion penodol antigen mewn samplau treialon clinigol. Mae gen i ddiddordeb hefyd mewn dadansoddiad ffenoteipig o gelloedd T a B mewn pobl â diabetes math 1 ac mewn pobl sydd ag awtogyrff ond nad ydyn nhw'n symud ymlaen i ddiabetes.
ID Orcid https://orcid.org/0000-0002-0821-4498
Web of Science ResearcherID: GYQ-7342-2022
Cyhoeddiad
2025
- Carter, K. et al. 2025. The efficacy and safety of ustekinumab in adolescents newly diagnosed with type 1 diabetes: the USTEK1D RCT. Efficacy and Mechanism Evaluation 12(1), pp. 1-66. (10.3310/fqln7416)
- Hanna, S. J. et al. 2025. The type 1 diabetes T cell receptor and B cell receptor repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium.. Diabetologia 68, pp. 186-202. (10.1007/s00125-024-06298-y)
2024
- Tatovic, D. et al. 2024. Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial. Nature Medicine 30, pp. 2657-2666. (10.1038/s41591-024-03115-2)
2023
- Taylor, P. et al. 2023. Factors predicting long-term outcome and the need for surgery in Graves orbitopathy: Extended follow-up from the CIRTED trial. The Journal of Clinical Endocrinology & Metabolism 108(10), pp. 2615-2625. (10.1210/clinem/dgad084)
- Hanna, S. J. et al. 2023. Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans. Frontiers in Immunology 14, article number: 1276255. (10.3389/fimmu.2023.1276255)
2022
- Boldison, J. et al. 2022. Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes. Diabetologia 65, article number: 343–355. (10.1007/s00125-021-05595-0)
2021
- Hanna, S. J., Tatovic, D., Thayer, T. C. and Dayan, C. M. 2021. Insights from single cell RNA sequencing Into the immunology of type 1 diabetes- cell phenotypes and antigen specificity. Frontiers in Immunology 12, article number: 751701. (10.3389/fimmu.2021.751701)
- Thayer, T. C., Davies, J., Pearson, J. A., Hanna, S. J., Wen, L. and Wong, F. S. 2021. Differentiating MHC-dependent and -independent mechanisms of lymph node stromal cell regulation of Proinsulin-specific CD8+ T-Cells in type 1 diabetes. Diabetes 70(2), pp. 529-537., article number: db191050. (10.2337/db19-1050)
- Codd, A. S. et al. 2021. Neutrophilia, lymphopenia and myeloid dysfunction: A living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology. Oxford Open Immunology 2(1), article number: iqab016. (10.1093/oxfimm/iqab016)
- Hanna, S. J. et al. 2021. T cell phenotypes in COVID-19 - a living review. Oxford Open Immunology 2(1) (10.1093/oxfimm/iqaa007)
- Scourfield, D. O. et al. 2021. The role and uses of antibodies in COVID-19 infections: a living review. Oxford Open Immunology 2(1), article number: iqab003. (10.1093/oxfimm/iqab003)
2020
- Hanna, S. J. et al. 2020. Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype. Diabetologia 63, pp. 1174-1185., article number: Diabetologia volume 63, pages1174–1185(2020). (10.1007/s00125-020-05114-7)
- Arikat, F. et al. 2020. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. Journal of Controlled Release 322, pp. 593-601. (10.1016/j.jconrel.2020.02.031)
2019
- Powell, W. et al. 2019. Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot. Journal of Immunological Methods 471, pp. 61-65. (10.1016/j.jim.2019.05.007)
2018
- Powell, W. E. et al. 2018. Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes. Diabetologia 61, pp. 1794-1803. (10.1007/s00125-018-4651-x)
2017
- Zhao, X., Coulman, S. A., Hanna, S. J., Wong, F. S., Dayan, C. M. and Birchall, J. C. 2017. Formulation of hydrophobic peptides for skin delivery via coated microneedles. Journal of Controlled Release 265, pp. 2-13. (10.1016/j.jconrel.2017.03.015)
2016
- Thayer, T. C. et al. 2016. Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T Cells in type 1 diabetes. Diabetes 65(11), pp. 3429-3439. (10.2337/db15-1649)
- Zhao, X. et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040)
2015
- Alhadj Ali, M. et al. 2015. Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin. Immunology 146(3), pp. 411-422. (10.1111/imm.12518)
2012
- Harris, S. J. et al. 2012. Genetic ablation of PI3K? results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels. European Journal of Immunology 42(12), pp. 3394-3404. (10.1002/eji.201242463)
- Alhadj Ali, M., Hanna, S., Wong, S. and Dayan, C. 2012. Functional modulation of epidermal dendritic cells by topical steroid treatment to optimise the tolerogenic potential of immunotherapy for type 1 diabetes [Abstract]. Diabetologia 55(S1), pp. S192. (10.1007/s00125-012-2688-9)
2011
- Harris, S. J. et al. 2011. Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility.. Journal of Immunology 186(8), pp. 4936-4945. (10.4049/jimmunol.1002350)
2010
- Parry, R. V., Harris, S. J. and Ward, S. G. 2010. Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1.. Biochimica et Biophysica Acta 1804(3), pp. 529-597. (10.1016/j.bbapap.2009.09.019)
2009
- Harris, S. 2009. PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategies. Current Opinion in Investigational Drugs 10(11), pp. 1151-1162.
2008
- Harris, S., Parry, R., Westwick, J. and Ward, S. 2008. Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. Journal of Biological Chemistry 283, pp. 2465-2469. (10.1074/jbc.r700044200)
Erthyglau
- Carter, K. et al. 2025. The efficacy and safety of ustekinumab in adolescents newly diagnosed with type 1 diabetes: the USTEK1D RCT. Efficacy and Mechanism Evaluation 12(1), pp. 1-66. (10.3310/fqln7416)
- Hanna, S. J. et al. 2025. The type 1 diabetes T cell receptor and B cell receptor repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium.. Diabetologia 68, pp. 186-202. (10.1007/s00125-024-06298-y)
- Tatovic, D. et al. 2024. Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial. Nature Medicine 30, pp. 2657-2666. (10.1038/s41591-024-03115-2)
- Taylor, P. et al. 2023. Factors predicting long-term outcome and the need for surgery in Graves orbitopathy: Extended follow-up from the CIRTED trial. The Journal of Clinical Endocrinology & Metabolism 108(10), pp. 2615-2625. (10.1210/clinem/dgad084)
- Hanna, S. J. et al. 2023. Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans. Frontiers in Immunology 14, article number: 1276255. (10.3389/fimmu.2023.1276255)
- Boldison, J. et al. 2022. Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes. Diabetologia 65, article number: 343–355. (10.1007/s00125-021-05595-0)
- Hanna, S. J., Tatovic, D., Thayer, T. C. and Dayan, C. M. 2021. Insights from single cell RNA sequencing Into the immunology of type 1 diabetes- cell phenotypes and antigen specificity. Frontiers in Immunology 12, article number: 751701. (10.3389/fimmu.2021.751701)
- Thayer, T. C., Davies, J., Pearson, J. A., Hanna, S. J., Wen, L. and Wong, F. S. 2021. Differentiating MHC-dependent and -independent mechanisms of lymph node stromal cell regulation of Proinsulin-specific CD8+ T-Cells in type 1 diabetes. Diabetes 70(2), pp. 529-537., article number: db191050. (10.2337/db19-1050)
- Codd, A. S. et al. 2021. Neutrophilia, lymphopenia and myeloid dysfunction: A living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology. Oxford Open Immunology 2(1), article number: iqab016. (10.1093/oxfimm/iqab016)
- Hanna, S. J. et al. 2021. T cell phenotypes in COVID-19 - a living review. Oxford Open Immunology 2(1) (10.1093/oxfimm/iqaa007)
- Scourfield, D. O. et al. 2021. The role and uses of antibodies in COVID-19 infections: a living review. Oxford Open Immunology 2(1), article number: iqab003. (10.1093/oxfimm/iqab003)
- Hanna, S. J. et al. 2020. Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype. Diabetologia 63, pp. 1174-1185., article number: Diabetologia volume 63, pages1174–1185(2020). (10.1007/s00125-020-05114-7)
- Arikat, F. et al. 2020. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. Journal of Controlled Release 322, pp. 593-601. (10.1016/j.jconrel.2020.02.031)
- Powell, W. et al. 2019. Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot. Journal of Immunological Methods 471, pp. 61-65. (10.1016/j.jim.2019.05.007)
- Powell, W. E. et al. 2018. Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes. Diabetologia 61, pp. 1794-1803. (10.1007/s00125-018-4651-x)
- Zhao, X., Coulman, S. A., Hanna, S. J., Wong, F. S., Dayan, C. M. and Birchall, J. C. 2017. Formulation of hydrophobic peptides for skin delivery via coated microneedles. Journal of Controlled Release 265, pp. 2-13. (10.1016/j.jconrel.2017.03.015)
- Thayer, T. C. et al. 2016. Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T Cells in type 1 diabetes. Diabetes 65(11), pp. 3429-3439. (10.2337/db15-1649)
- Zhao, X. et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040)
- Alhadj Ali, M. et al. 2015. Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin. Immunology 146(3), pp. 411-422. (10.1111/imm.12518)
- Harris, S. J. et al. 2012. Genetic ablation of PI3K? results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels. European Journal of Immunology 42(12), pp. 3394-3404. (10.1002/eji.201242463)
- Alhadj Ali, M., Hanna, S., Wong, S. and Dayan, C. 2012. Functional modulation of epidermal dendritic cells by topical steroid treatment to optimise the tolerogenic potential of immunotherapy for type 1 diabetes [Abstract]. Diabetologia 55(S1), pp. S192. (10.1007/s00125-012-2688-9)
- Harris, S. J. et al. 2011. Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility.. Journal of Immunology 186(8), pp. 4936-4945. (10.4049/jimmunol.1002350)
- Parry, R. V., Harris, S. J. and Ward, S. G. 2010. Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1.. Biochimica et Biophysica Acta 1804(3), pp. 529-597. (10.1016/j.bbapap.2009.09.019)
- Harris, S. 2009. PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategies. Current Opinion in Investigational Drugs 10(11), pp. 1151-1162.
- Harris, S., Parry, R., Westwick, J. and Ward, S. 2008. Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. Journal of Biological Chemistry 283, pp. 2465-2469. (10.1074/jbc.r700044200)
Addysgu
- MSc Imiwnoleg Glinigol ac Arbrofol Gymhwysol
- MSc Biowybodeg
- GW4 DTP
Bywgraffiad
Anrhydeddau a dyfarniadau
- 2023 - Gwobr teithio ymchwilydd ifanc INNODIA IDS
- 2022 - Gwobr poster, Cyngres Cymdeithas Imiwnoleg Prydain
- 2022 - Gwobr Deithio, Cymdeithas Imiwnoleg Prydain
- 2022 - Gwobr Teithio Cymdeithas y Meddygon
- 2021 - Cyrhaeddodd rownd derfynol Gwobr Dathlu Rhagoriaeth Prifysgol Caerdydd ar gyfer Clwb Cyfnodolyn Cymunedol COVID-19 yn y categori Rhagoriaeth mewn Ymchwil
- 2020 - Sefydliad Ymchwil a Lles Diabetes Yr Athro David Matthews Cymrodoriaeth Ymchwil Anghlinigol
- 2020 - Cymdeithas Imiwnoleg Diabetes o safon uchel
- 2020 - Gwobr Teithio, Cymdeithas Imiwnoleg Prydain
Aelodaethau proffesiynol
- 2022 - Cymrawd yr Academi Addysg Uwch (FHEA)
- 2022 - Cymrawd Addysg Prifysgol Caerdydd
- 2021 - Cymrawd Cyswllt yr Academi Addysg Uwch (AFHEA)
Ymrwymiadau siarad cyhoeddus
- Cyngres Cymdeithas Diabetes 2024, Bruges, Gwlad Belg
- 2024 - ADA Orlando, Florida, UDA. Siaradwr gwahoddedig
- 2023 - The SugarScience Ask the Expert
- 2023 - South West RNA Club UK
- Cynhadledd flynyddol Cymdeithas Meddygon Prydain Fawr ac Iwerddon 2022, Dulyn
- 2022-British Society for Immunology Congress, Lerpwl
- Cyfarfod blynyddol Cymdeithas endocrin a Diabetes Cymru 2022-Cymru, Caerdydd
- 2021 - Cytokines2021 Sesiwn Cymdeithas Frenhinol Bioleg: NGS-omics a delweddu
Pwyllgorau ac adolygu
- Frontiers in Immunology: Review Editor on Editorial Board of Autoimmune and Autoinflamatory Disorders
- Gweithgor Diwylliant Ymchwil - Cynrychiolydd Ymchwilydd Gyrfa Gynnar
- Fforwm Ymchwilydd Gyrfa Gynnar yr Ysgol Meddygaeth - Cynrychiolydd yr Is-adran Heintiau ac Imiwnedd
