![Stephanie Hanna](https://profiles-cardiff.imgix.net/attachments/2447?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Stephanie Hanna
Cymrawd Ymchwil
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Cymrawd Ymchwil a Sefydliad Lles Diabetes
Mae fy ymchwil yn canolbwyntio ar imiwnoleg diabetes math 1, gan ddefnyddio dulliau biowybodeg newydd i ddadansoddi ymatebion penodol antigen mewn samplau treialon clinigol. Mae gen i ddiddordeb hefyd mewn dadansoddiad ffenoteipig o gelloedd T a B mewn pobl â diabetes math 1 ac mewn pobl sydd ag awtogyrff ond nad ydyn nhw'n symud ymlaen i ddiabetes.
ID Orcid https://orcid.org/0000-0002-0821-4498
Web of Science ResearcherID: GYQ-7342-2022
Cyhoeddiad
2023
- Taylor, P. et al. 2023. Factors predicting long-term outcome and the need for surgery in Graves orbitopathy: Extended follow-up from the CIRTED trial. The Journal of Clinical Endocrinology & Metabolism 108(10), pp. 2615-2625. (10.1210/clinem/dgad084)
- Hanna, S. J. et al. 2023. Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans. Frontiers in Immunology 14, article number: 1276255. (10.3389/fimmu.2023.1276255)
2022
- Boldison, J. et al. 2022. Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes. Diabetologia 65, article number: 343–355. (10.1007/s00125-021-05595-0)
2021
- Hanna, S. J., Tatovic, D., Thayer, T. C. and Dayan, C. M. 2021. Insights from single cell RNA sequencing Into the immunology of type 1 diabetes- cell phenotypes and antigen specificity. Frontiers in Immunology 12, article number: 751701. (10.3389/fimmu.2021.751701)
- Thayer, T. C., Davies, J., Pearson, J. A., Hanna, S. J., Wen, L. and Wong, F. S. 2021. Differentiating MHC-dependent and -independent mechanisms of lymph node stromal cell regulation of Proinsulin-specific CD8+ T-Cells in type 1 diabetes. Diabetes 70(2), pp. 529-537., article number: db191050. (10.2337/db19-1050)
- Scourfield, D. O. et al. 2021. The role and uses of antibodies in COVID-19 infections: a living review. Oxford Open Immunology 2(1), article number: iqab003. (10.1093/oxfimm/iqab003)
- Hanna, S. J. et al. 2021. T cell phenotypes in COVID-19 - a living review. Oxford Open Immunology 2(1) (10.1093/oxfimm/iqaa007)
- Codd, A. S. et al. 2021. Neutrophilia, lymphopenia and myeloid dysfunction: A living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology. Oxford Open Immunology 2(1), article number: iqab016. (10.1093/oxfimm/iqab016)
2020
- Hanna, S. J. et al. 2020. Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype. Diabetologia 63, pp. 1174-1185., article number: Diabetologia volume 63, pages1174–1185(2020). (10.1007/s00125-020-05114-7)
- Arikat, F. et al. 2020. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. Journal of Controlled Release 322, pp. 593-601. (10.1016/j.jconrel.2020.02.031)
2019
- Powell, W. et al. 2019. Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot. Journal of Immunological Methods 471, pp. 61-65. (10.1016/j.jim.2019.05.007)
2018
- Powell, W. E. et al. 2018. Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes. Diabetologia 61, pp. 1794-1803. (10.1007/s00125-018-4651-x)
2017
- Zhao, X., Coulman, S. A., Hanna, S. J., Wong, F. S., Dayan, C. M. and Birchall, J. C. 2017. Formulation of hydrophobic peptides for skin delivery via coated microneedles. Journal of Controlled Release 265, pp. 2-13. (10.1016/j.jconrel.2017.03.015)
2016
- Thayer, T. C. et al. 2016. Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T Cells in type 1 diabetes. Diabetes 65(11), pp. 3429-3439. (10.2337/db15-1649)
- Zhao, X. et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040)
2015
- Alhadj Ali, M. et al. 2015. Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin. Immunology 146(3), pp. 411-422. (10.1111/imm.12518)
2012
- Harris, S. J. et al. 2012. Genetic ablation of PI3K? results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels. European Journal of Immunology 42(12), pp. 3394-3404. (10.1002/eji.201242463)
- Alhadj Ali, M., Hanna, S., Wong, S. and Dayan, C. 2012. Functional modulation of epidermal dendritic cells by topical steroid treatment to optimise the tolerogenic potential of immunotherapy for type 1 diabetes [Abstract]. Diabetologia 55(S1), pp. S192. (10.1007/s00125-012-2688-9)
2011
- Harris, S. J. et al. 2011. Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility.. Journal of Immunology 186(8), pp. 4936-4945. (10.4049/jimmunol.1002350)
2010
- Parry, R. V., Harris, S. J. and Ward, S. G. 2010. Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1.. Biochimica et Biophysica Acta 1804(3), pp. 529-597. (10.1016/j.bbapap.2009.09.019)
2009
- Harris, S. 2009. PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategies. Current Opinion in Investigational Drugs 10(11), pp. 1151-1162.
2008
- Harris, S., Parry, R., Westwick, J. and Ward, S. 2008. Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. Journal of Biological Chemistry 283, pp. 2465-2469. (10.1074/jbc.r700044200)
Erthyglau
- Taylor, P. et al. 2023. Factors predicting long-term outcome and the need for surgery in Graves orbitopathy: Extended follow-up from the CIRTED trial. The Journal of Clinical Endocrinology & Metabolism 108(10), pp. 2615-2625. (10.1210/clinem/dgad084)
- Hanna, S. J. et al. 2023. Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans. Frontiers in Immunology 14, article number: 1276255. (10.3389/fimmu.2023.1276255)
- Boldison, J. et al. 2022. Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes. Diabetologia 65, article number: 343–355. (10.1007/s00125-021-05595-0)
- Hanna, S. J., Tatovic, D., Thayer, T. C. and Dayan, C. M. 2021. Insights from single cell RNA sequencing Into the immunology of type 1 diabetes- cell phenotypes and antigen specificity. Frontiers in Immunology 12, article number: 751701. (10.3389/fimmu.2021.751701)
- Thayer, T. C., Davies, J., Pearson, J. A., Hanna, S. J., Wen, L. and Wong, F. S. 2021. Differentiating MHC-dependent and -independent mechanisms of lymph node stromal cell regulation of Proinsulin-specific CD8+ T-Cells in type 1 diabetes. Diabetes 70(2), pp. 529-537., article number: db191050. (10.2337/db19-1050)
- Scourfield, D. O. et al. 2021. The role and uses of antibodies in COVID-19 infections: a living review. Oxford Open Immunology 2(1), article number: iqab003. (10.1093/oxfimm/iqab003)
- Hanna, S. J. et al. 2021. T cell phenotypes in COVID-19 - a living review. Oxford Open Immunology 2(1) (10.1093/oxfimm/iqaa007)
- Codd, A. S. et al. 2021. Neutrophilia, lymphopenia and myeloid dysfunction: A living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology. Oxford Open Immunology 2(1), article number: iqab016. (10.1093/oxfimm/iqab016)
- Hanna, S. J. et al. 2020. Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype. Diabetologia 63, pp. 1174-1185., article number: Diabetologia volume 63, pages1174–1185(2020). (10.1007/s00125-020-05114-7)
- Arikat, F. et al. 2020. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. Journal of Controlled Release 322, pp. 593-601. (10.1016/j.jconrel.2020.02.031)
- Powell, W. et al. 2019. Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot. Journal of Immunological Methods 471, pp. 61-65. (10.1016/j.jim.2019.05.007)
- Powell, W. E. et al. 2018. Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes. Diabetologia 61, pp. 1794-1803. (10.1007/s00125-018-4651-x)
- Zhao, X., Coulman, S. A., Hanna, S. J., Wong, F. S., Dayan, C. M. and Birchall, J. C. 2017. Formulation of hydrophobic peptides for skin delivery via coated microneedles. Journal of Controlled Release 265, pp. 2-13. (10.1016/j.jconrel.2017.03.015)
- Thayer, T. C. et al. 2016. Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T Cells in type 1 diabetes. Diabetes 65(11), pp. 3429-3439. (10.2337/db15-1649)
- Zhao, X. et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040)
- Alhadj Ali, M. et al. 2015. Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin. Immunology 146(3), pp. 411-422. (10.1111/imm.12518)
- Harris, S. J. et al. 2012. Genetic ablation of PI3K? results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels. European Journal of Immunology 42(12), pp. 3394-3404. (10.1002/eji.201242463)
- Alhadj Ali, M., Hanna, S., Wong, S. and Dayan, C. 2012. Functional modulation of epidermal dendritic cells by topical steroid treatment to optimise the tolerogenic potential of immunotherapy for type 1 diabetes [Abstract]. Diabetologia 55(S1), pp. S192. (10.1007/s00125-012-2688-9)
- Harris, S. J. et al. 2011. Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility.. Journal of Immunology 186(8), pp. 4936-4945. (10.4049/jimmunol.1002350)
- Parry, R. V., Harris, S. J. and Ward, S. G. 2010. Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1.. Biochimica et Biophysica Acta 1804(3), pp. 529-597. (10.1016/j.bbapap.2009.09.019)
- Harris, S. 2009. PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategies. Current Opinion in Investigational Drugs 10(11), pp. 1151-1162.
- Harris, S., Parry, R., Westwick, J. and Ward, S. 2008. Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. Journal of Biological Chemistry 283, pp. 2465-2469. (10.1074/jbc.r700044200)
Addysgu
- MSc Imiwnoleg Glinigol ac Arbrofol Gymhwysol
- MSc Biowybodeg
- GW4 DTP
Bywgraffiad
Anrhydeddau a dyfarniadau
- 2023 - Gwobr teithio ymchwilydd ifanc INNODIA IDS
- 2022 - Gwobr poster, Cyngres Cymdeithas Imiwnoleg Prydain
- 2022 - Gwobr Deithio, Cymdeithas Imiwnoleg Prydain
- 2022 - Gwobr Teithio Cymdeithas y Meddygon
- 2021 - Cyrhaeddodd rownd derfynol Gwobr Dathlu Rhagoriaeth Prifysgol Caerdydd ar gyfer Clwb Cyfnodolyn Cymunedol COVID-19 yn y categori Rhagoriaeth mewn Ymchwil
- 2020 - Sefydliad Ymchwil a Lles Diabetes Yr Athro David Matthews Cymrodoriaeth Ymchwil Anghlinigol
- 2020 - Cymdeithas Imiwnoleg Diabetes o safon uchel
- 2020 - Gwobr Teithio, Cymdeithas Imiwnoleg Prydain
Aelodaethau proffesiynol
- 2022 - Cymrawd yr Academi Addysg Uwch (FHEA)
- 2022 - Cymrawd Addysg Prifysgol Caerdydd
- 2021 - Cymrawd Cyswllt yr Academi Addysg Uwch (AFHEA)
Ymrwymiadau siarad cyhoeddus
- 2023 - The SugarScience Ask the Expert
- 2023 - South West RNA Club UK
- Cynhadledd flynyddol Cymdeithas Meddygon Prydain Fawr ac Iwerddon 2022, Dulyn
- 2022-British Society for Immunology Congress, Lerpwl
- Cyfarfod blynyddol Cymdeithas endocrin a Diabetes Cymru 2022-Cymru, Caerdydd
- 2021 - Cytokines2021 Sesiwn Cymdeithas Frenhinol Bioleg: NGS-omics a delweddu
Pwyllgorau ac adolygu
- Frontiers in Immunology: Review Editor on Editorial Board of Autoimmune and Autoinflamatory Disorders
- Gweithgor Diwylliant Ymchwil - Cynrychiolydd Ymchwilydd Gyrfa Gynnar
- Fforwm Ymchwilydd Gyrfa Gynnar yr Ysgol Meddygaeth - Cynrychiolydd yr Is-adran Heintiau ac Imiwnedd
Ymgysylltu
"What Diabetes Means To Us", arddangosfa gelf seiliedig ar ymchwil sy'n dathlu can mlynedd ers darganfod Inswlin.
https://cardiffandvale.art/2021/10/13/what-diabetes-means-to-us/
Er mwyn anrhydeddu'r canmlwyddiant pwysig hwn, mae'r Athro F. Susan Wong, mewn cydweithrediad ag aelodau o Grŵp Ymchwil Diabetes Prifysgol Caerdydd a'r Artist Preswyl, Bridget O'Brien, wedi trawsnewid Oriel Hearth yn arddangosfa sy'n llawn gwybodaeth weledol sy'n canolbwyntio ar bwysigrwydd ymchwil diabetes ac yn annog trafodaethau agored am Ddiabetes a'r hyn y mae'n ei olygu i'r rhai sy'n byw gydag ef.
"Ymchwil Diabetes Math 1 - Prifysgol Caerdydd" Dyma fideo 20 munud, sy'n addas ar gyfer cynulleidfaoedd lleyg sy'n rhoi esboniad o imiwnoleg diabetes math 1 ac yn disgrifio'r ymchwil a wnaed yng Nghaerdydd https://www.youtube.com/watch?v=D8nt1gJU2HU
