![Stephanie Hanna](https://profiles-cardiff.imgix.net/attachments/2447?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Stephanie Hanna
Research Fellow
- Available for postgraduate supervision
Overview
Diabetes Research And Wellness Foundation Research Fellow
My research focusses on the immunology of type 1 diabetes, using new bioinformatics approaches to analyse antigen specific responses in clinical trial samples. I am also interested in phenotypic analysis of T and B cells in people with type 1 diabetes and in people who have autoantibodies but do not progress to diabetes.
Orcid ID https://orcid.org/0000-0002-0821-4498
Web of Science ResearcherID: GYQ-7342-2022
Publication
2023
- Taylor, P. et al. 2023. Factors predicting long-term outcome and the need for surgery in Graves orbitopathy: Extended follow-up from the CIRTED trial. The Journal of Clinical Endocrinology & Metabolism 108(10), pp. 2615-2625. (10.1210/clinem/dgad084)
- Hanna, S. J. et al. 2023. Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans. Frontiers in Immunology 14, article number: 1276255. (10.3389/fimmu.2023.1276255)
2022
- Boldison, J. et al. 2022. Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes. Diabetologia 65, article number: 343–355. (10.1007/s00125-021-05595-0)
2021
- Hanna, S. J., Tatovic, D., Thayer, T. C. and Dayan, C. M. 2021. Insights from single cell RNA sequencing Into the immunology of type 1 diabetes- cell phenotypes and antigen specificity. Frontiers in Immunology 12, article number: 751701. (10.3389/fimmu.2021.751701)
- Thayer, T. C., Davies, J., Pearson, J. A., Hanna, S. J., Wen, L. and Wong, F. S. 2021. Differentiating MHC-dependent and -independent mechanisms of lymph node stromal cell regulation of Proinsulin-specific CD8+ T-Cells in type 1 diabetes. Diabetes 70(2), pp. 529-537., article number: db191050. (10.2337/db19-1050)
- Scourfield, D. O. et al. 2021. The role and uses of antibodies in COVID-19 infections: a living review. Oxford Open Immunology 2(1), article number: iqab003. (10.1093/oxfimm/iqab003)
- Hanna, S. J. et al. 2021. T cell phenotypes in COVID-19 - a living review. Oxford Open Immunology 2(1) (10.1093/oxfimm/iqaa007)
- Codd, A. S. et al. 2021. Neutrophilia, lymphopenia and myeloid dysfunction: A living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology. Oxford Open Immunology 2(1), article number: iqab016. (10.1093/oxfimm/iqab016)
2020
- Hanna, S. J. et al. 2020. Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype. Diabetologia 63, pp. 1174-1185., article number: Diabetologia volume 63, pages1174–1185(2020). (10.1007/s00125-020-05114-7)
- Arikat, F. et al. 2020. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. Journal of Controlled Release 322, pp. 593-601. (10.1016/j.jconrel.2020.02.031)
2019
- Powell, W. et al. 2019. Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot. Journal of Immunological Methods 471, pp. 61-65. (10.1016/j.jim.2019.05.007)
2018
- Powell, W. E. et al. 2018. Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes. Diabetologia 61, pp. 1794-1803. (10.1007/s00125-018-4651-x)
2017
- Zhao, X., Coulman, S. A., Hanna, S. J., Wong, F. S., Dayan, C. M. and Birchall, J. C. 2017. Formulation of hydrophobic peptides for skin delivery via coated microneedles. Journal of Controlled Release 265, pp. 2-13. (10.1016/j.jconrel.2017.03.015)
2016
- Thayer, T. C. et al. 2016. Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T Cells in type 1 diabetes. Diabetes 65(11), pp. 3429-3439. (10.2337/db15-1649)
- Zhao, X. et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040)
2015
- Alhadj Ali, M. et al. 2015. Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin. Immunology 146(3), pp. 411-422. (10.1111/imm.12518)
2012
- Harris, S. J. et al. 2012. Genetic ablation of PI3K? results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels. European Journal of Immunology 42(12), pp. 3394-3404. (10.1002/eji.201242463)
- Alhadj Ali, M., Hanna, S., Wong, S. and Dayan, C. 2012. Functional modulation of epidermal dendritic cells by topical steroid treatment to optimise the tolerogenic potential of immunotherapy for type 1 diabetes [Abstract]. Diabetologia 55(S1), pp. S192. (10.1007/s00125-012-2688-9)
2011
- Harris, S. J. et al. 2011. Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility.. Journal of Immunology 186(8), pp. 4936-4945. (10.4049/jimmunol.1002350)
2010
- Parry, R. V., Harris, S. J. and Ward, S. G. 2010. Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1.. Biochimica et Biophysica Acta 1804(3), pp. 529-597. (10.1016/j.bbapap.2009.09.019)
2009
- Harris, S. 2009. PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategies. Current Opinion in Investigational Drugs 10(11), pp. 1151-1162.
2008
- Harris, S., Parry, R., Westwick, J. and Ward, S. 2008. Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. Journal of Biological Chemistry 283, pp. 2465-2469. (10.1074/jbc.r700044200)
Articles
- Taylor, P. et al. 2023. Factors predicting long-term outcome and the need for surgery in Graves orbitopathy: Extended follow-up from the CIRTED trial. The Journal of Clinical Endocrinology & Metabolism 108(10), pp. 2615-2625. (10.1210/clinem/dgad084)
- Hanna, S. J. et al. 2023. Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans. Frontiers in Immunology 14, article number: 1276255. (10.3389/fimmu.2023.1276255)
- Boldison, J. et al. 2022. Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes. Diabetologia 65, article number: 343–355. (10.1007/s00125-021-05595-0)
- Hanna, S. J., Tatovic, D., Thayer, T. C. and Dayan, C. M. 2021. Insights from single cell RNA sequencing Into the immunology of type 1 diabetes- cell phenotypes and antigen specificity. Frontiers in Immunology 12, article number: 751701. (10.3389/fimmu.2021.751701)
- Thayer, T. C., Davies, J., Pearson, J. A., Hanna, S. J., Wen, L. and Wong, F. S. 2021. Differentiating MHC-dependent and -independent mechanisms of lymph node stromal cell regulation of Proinsulin-specific CD8+ T-Cells in type 1 diabetes. Diabetes 70(2), pp. 529-537., article number: db191050. (10.2337/db19-1050)
- Scourfield, D. O. et al. 2021. The role and uses of antibodies in COVID-19 infections: a living review. Oxford Open Immunology 2(1), article number: iqab003. (10.1093/oxfimm/iqab003)
- Hanna, S. J. et al. 2021. T cell phenotypes in COVID-19 - a living review. Oxford Open Immunology 2(1) (10.1093/oxfimm/iqaa007)
- Codd, A. S. et al. 2021. Neutrophilia, lymphopenia and myeloid dysfunction: A living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology. Oxford Open Immunology 2(1), article number: iqab016. (10.1093/oxfimm/iqab016)
- Hanna, S. J. et al. 2020. Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype. Diabetologia 63, pp. 1174-1185., article number: Diabetologia volume 63, pages1174–1185(2020). (10.1007/s00125-020-05114-7)
- Arikat, F. et al. 2020. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. Journal of Controlled Release 322, pp. 593-601. (10.1016/j.jconrel.2020.02.031)
- Powell, W. et al. 2019. Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot. Journal of Immunological Methods 471, pp. 61-65. (10.1016/j.jim.2019.05.007)
- Powell, W. E. et al. 2018. Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes. Diabetologia 61, pp. 1794-1803. (10.1007/s00125-018-4651-x)
- Zhao, X., Coulman, S. A., Hanna, S. J., Wong, F. S., Dayan, C. M. and Birchall, J. C. 2017. Formulation of hydrophobic peptides for skin delivery via coated microneedles. Journal of Controlled Release 265, pp. 2-13. (10.1016/j.jconrel.2017.03.015)
- Thayer, T. C. et al. 2016. Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T Cells in type 1 diabetes. Diabetes 65(11), pp. 3429-3439. (10.2337/db15-1649)
- Zhao, X. et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040)
- Alhadj Ali, M. et al. 2015. Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin. Immunology 146(3), pp. 411-422. (10.1111/imm.12518)
- Harris, S. J. et al. 2012. Genetic ablation of PI3K? results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels. European Journal of Immunology 42(12), pp. 3394-3404. (10.1002/eji.201242463)
- Alhadj Ali, M., Hanna, S., Wong, S. and Dayan, C. 2012. Functional modulation of epidermal dendritic cells by topical steroid treatment to optimise the tolerogenic potential of immunotherapy for type 1 diabetes [Abstract]. Diabetologia 55(S1), pp. S192. (10.1007/s00125-012-2688-9)
- Harris, S. J. et al. 2011. Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility.. Journal of Immunology 186(8), pp. 4936-4945. (10.4049/jimmunol.1002350)
- Parry, R. V., Harris, S. J. and Ward, S. G. 2010. Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1.. Biochimica et Biophysica Acta 1804(3), pp. 529-597. (10.1016/j.bbapap.2009.09.019)
- Harris, S. 2009. PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategies. Current Opinion in Investigational Drugs 10(11), pp. 1151-1162.
- Harris, S., Parry, R., Westwick, J. and Ward, S. 2008. Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. Journal of Biological Chemistry 283, pp. 2465-2469. (10.1074/jbc.r700044200)
Teaching
- MSc Applied Clinical and Experimental Immunology
- MSc Bioinformatics
- GW4 DTP
Biography
Honours and awards
- 2023- INNODIA IDS young investigator travel award
- 2022- Poster prize, British Society for Immunology Congress
- 2022- Travel Award, British Society for Immunology
- 2022- Association of Physicians Travel Award
- 2021- Cardiff University Celebrating Excellence Award finalist for the COVID-19 Community Journal Club in the Excellence in Research category
- 2020 - Diabetes Research and Wellness Foundation Professor David Matthews Non-Clinical Research Fellowship
- 2020 - High-scoring abstract, Immunology of Diabetes Society
- 2020 - Travel Award, British Society for Immunology
Professional memberships
- 2022- Fellow of the Higher Education Academy (FHEA)
- 2022- Cardiff University Education Fellow
- 2021- Associate Fellow of the Higher Education Academy (AFHEA)
Speaking engagements
- 2023- TheSugarScience Ask the Expert
- 2023- South West RNA Club UK
- 2022-Association of Physicians of Great Britain and Ireland annual conference, Dublin
- 2022-British Society for Immunology Congress, Liverpool
- 2022-Welsh Endocrine and Diabetes society annual meeting, Cardiff
- 2021- Cytokines2021 The Royal Society of Biology session: NGS-omics and visualisation
Committees and reviewing
- Frontiers in Immunology: Review Editor on Editorial Board of Autoimmune and Autoinflamatory Disorders
- Research Culture Working Group- Early Career Researcher representative
- School of Medicine Early Career Researcher Forum- Division of Infection and Immunity representative
Engagement
2023- United through diabetes meet the researchers,
2021-“What Diabetes Means To Us”, a research based art exhibition celebrating one hundred years since the discovery of Insulin.
https://cardiffandvale.art/2021/10/13/what-diabetes-means-to-us/
To honour this important centenary, Professor F. Susan Wong, in collaboration with members of Cardiff University Diabetes Research Group and Artist in Residence, Bridget O’Brien, have transformed the Hearth Gallery into a visually informative exhibition that focuses on the importance of Diabetes research and encourages open discussions about Diabetes and what it means to those who live with it.
“Type 1 Diabetes Research - Cardiff University” This is a 20 minute video, suitable for lay audiences which gives an explanation of the immunology of type 1 diabetes and describes the research undertaken at Cardiff https://www.youtube.com/watch?v=D8nt1gJU2HU
