Dr Anthony Hayes

2023

• Hayes, A. J. and Melrose, J. 2023. HS, an ancient molecular recognition and information storage glycosaminoglycan, equips HS-proteoglycans with diverse matrix and cell-interactive properties operative in tissue development and tissue function in health and disease. International Journal of Molecular Sciences 24(2), article number: 1148. (10.3390/ijms24021148)

2022

• Hayes, A. J., Farrugia, B. L., Biose, I. J., Bix, G. J. and Melrose, J. 2022. Perlecan, a multi-functional, cell-instructive, matrix-stabilizing proteoglycan with roles in tissue development has relevance to connective tissue repair and regeneration. Frontiers in Cell and Developmental Biology 10, article number: 856261. (10.3389/fcell.2022.856261)
• Hayes, A. J., Whitelock, J. and Melrose, J. 2022. Regulation of FGF-2, FGF-18 and transcription factor activity by perlecan in the maturational development of transitional rudiment and growth plate cartilages and in the maintenance of permanent cartilage homeostasis. International Journal of Molecular Sciences 23(4), article number: 1934. (10.3390/ijms23041934)
• Bricking, A., Hayes, A. and Madgwick, R. 2022. An interim report on histological analysis of human bones from Fishmonger's Swallet, Gloucestershire. Proceedings of the University of Bristol Speleological Society 29(1), pp. 67-86.

2021

• Hayes, A. J. and Melrose, J. 2021. Neural tissue homeostasis and repair is regulated via CS and DS proteoglycan motifs. Frontiers in Cell and Developmental Biology 9, article number: 696650. (10.3389/fcell.2021.696640)
• Melrose, J., Hayes, A. J. and Bix, G. 2021. The CNS/PNS extracellular matrix provides instructive guidance cues to neural cells and neuroregulatory proteins in neural development and repair. International Journal of Molecular Sciences 22(11), article number: 5583. (10.3390/ijms22115583)
• Hayes, A. J. and Melrose, J. 2021. What are the potential roles of nuclear perlecan and other heparan sulphate proteoglycans in the normal and malignant phenotype. International Journal of Molecular Sciences 22(9), article number: 4415. (10.3390/ijms22094415)
• Guilak, F., Hayes, A. J. and Melrose, J. 2021. Perlecan in pericellular mechanosensory cell-matrix communication, extracellular matrix stabilisation and mechanoregulation of load-bearing connective tissues. International Journal of Molecular Sciences 22(5), article number: 2716. (10.3390/ijms22052716)
• Markov, P., Hayes, A. J., Zhu, H., Boote, C. and Blain, E. J. 2021. 3D immuno-confocal image reconstruction of fibroblast cytoskeleton and nucleus architecture. Journal of Biophotonics 14(1), article number: e202000202. (10.1002/jbio.202000202)
• Hayes, A. J. and Melrose, J. 2021. 3D distribution of perlecan within intervertebral disc chondrons suggests novel regulatory roles for this multifunctional modular heparan sulphate proteoglycan. European Cells and Materials 41, pp. 73-89. (10.22203/eCM.v041a06)
• Ashworth, S. et al. 2021. Chondroitin sulfate as a potential modulator of the stem cell niche in cornea. Frontiers in Cell and Developmental Biology 8, article number: 567358. (10.3389/fcell.2020.567358)

2020

• Hayes, A. J. and Melrose, J. 2020. Electro-stimulation, a promising therapeutic treatment modality for tissue repair: emerging roles of sulfated glycosaminoglycans as electro-regulatory mediators of intrinsic repair processes. Advanced Therapeutics 3(11), article number: 2000151. (10.1002/adtp.202000151)
• Guschina, I. A., Hayes, A. J. and Ormerod, S. J. 2020. Polystyrene microplastics decrease accumulation of essential fatty acids in common freshwater algae. Environmental Pollution 263(PartB), article number: 114425. (10.1016/j.envpol.2020.114425)
• Hayes, A. J. and Melrose, J. 2020. Keratan sulphate in the tumour environment. In: Tumor Microenvironment: Extracellular Matrix Components – Part A., Vol. 1245. Advances in Experimental Medicine and Biology Berlin: Springer-Verlag, pp. 39-66., (10.1007/978-3-030-40146-7_2)
• Hayes, A. J. and Melrose, J. 2020. Immunolocalization of keratan sulfate in rat spinal tissues using the keratanase generated BKS-1(+) neoepitope: correlation of expression patterns with the slass II SLRPs, lumican and keratocan. Cells 9(4), article number: 826. (10.3390/cells9040826)
• Hayes, A. J. and Melrose, J. 2020. Aggrecan, the primary weight-bearing cartilage proteoglycan, has context-dependent, cell-directive properties in embryonic development and neurogenesis: aggrecan glycan side chain modifications convey interactive biodiversity. Biomolecules 10(9), article number: 1244. (10.3390/biom10091244)
• Lloyd, D. et al. 2020. Functional imaging of a model unicell: Spironucleus vortens as an anaerobic but aerotolerant flagellated protist. Advances in Microbial Physiology 76, pp. 41-79. (10.1016/bs.ampbs.2020.01.002)

2019

• Hayes, A. J. and Melrose, J. 2019. Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco?supplementation in Orthobiologics. Advanced Therapeutics 2(8), article number: 1900034. (10.1002/adtp.201900034)
• Jones, S., Caws, T., Hayes, A., Marsh Durban, V., Corteling, R. and Watson, P. 2019. Characterizing the cellular uptake of neural stem-cell derived exosomes using live-cell imaging techniques. Presented at: ISEV2019 Annual Meeting, Kyoto, Japan, 24-28 April 2019, Vol. 8. Vol. sup1. Wiley pp. IP12., (10.1080/20013078.2019.1593587)
• Groves, L. M. et al. 2019. Fluorescent functionalised naphthalimides and their Au(i)–NHC complexes for potential use in cellular bioimaging. Dalton Transactions 48(5), pp. 1599-1612. (10.1039/C8DT04069A)

2018

• Hayes, A. J., Smith, S. M., Caterson, B. and Melrose, J. 2018. Concise Review: Stem/progenitor cell proteoglycans decorated with 7-D-4, 4-C-3, and 3-B-3(-) chondroitin sulfate motifs are morphogenetic markers of tissue development. STEM CELLS 36(10), pp. 1475-1486. (10.1002/stem.2860)
• Hayes, A. J. and Melrose, J. 2018. Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate. Biochemical Journal 475(15), pp. 2511-2545. (10.1042/BCJ20180283)
• Hallett, A. J. et al. 2018. Exploring the cellular uptake and localisation of phosphorescent rhenium fac-tricarbonyl metallosurfactants as a function of lipophilicity. Dalton Transactions 47(40), pp. 14241-14253. (10.1039/C8DT00669E)
• Hayes, A., Sugahara, K., Farrugia, B., Whitelock, J. M., Caterson, B. and Melrose, J. 2018. Biodiversity of CS-proteoglycan sulphation motifs: chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis. Biochemical Journal 475(3), pp. 587-620. (10.1042/BCJ20170820)
• Zaki, A. et al. 2018. Defined covalent assembly of protein molecules on graphene using a genetically encoded photochemical reaction handle. RSC Advances 8, pp. 5768-5775. (10.1039/c7ra11166e)

2017

• Langdon-Jones, E. E. et al. 2017. Luminescent 1,8-Naphthalimide-Derived ReI Complexes: syntheses, spectroscopy, X-ray structure and preliminary bioimaging in fission yeast cells. European Journal of Inorganic Chemistry 2017(44), pp. 5279-5287. (10.1002/ejic.201700549)
• Perry, I. et al. 2017. Production of 3D printed scale models from microscope volume datasets for use in STEM education. EMS Engineering Science Journal 1(1), article number: 2.
• Sands, K. M. et al. 2017. Respiratory pathogen colonisation of dental plaque, the lower airways and endotracheal tube biofilms during mechanical ventilation. Journal of Critical Care 37, pp. 30-37. (10.1016/j.jcrc.2016.07.019)
• Pope, S. J. A., Langdon-Jones, E., Jones, A., Williams, C. F., Hayes, A. J., Lloyd, D. and Mottram, H. J. 2017. Anticancer, azonafide-inspired fluorescent ligands and their rhenium(I) complexes for cellular imaging. European Journal of Inorganic Chemistry 2017(3), pp. 759-766. (10.1002/ejic.201601271)

2016

• Hayes, A. J., Shu, C. C., Lord, M. S., Little, C. B., Whitelock, J. M. and Melrose, J. 2016. Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc. European Cells and Materials 32, pp. 40-57. (10.22203/eCM.v032a03)
• Hayes, A. J., Hughes, C. E., Smith, S. M., Caterson, B., Little, C. B. and Melrose, J. 2016. The CS sulphation motifs 4C3, 7D4, 3B3[-]; and perlecan identify stem cell populations and niches, activated progenitor cells and transitional tissue development in the fetal human elbow. Stem Cells and Development 25(11), pp. 836-847. (10.1089/scd.2016.0054)
• Kille, P. et al. 2016. Venus trapped, Mars transits: Cu and Fe redox chemistry, cellular topography, and in situ ligand binding in terrestrial isopod hepatopancreas. Open Biology Journal 6(3), pp. -., article number: 150270. (10.1098/rsob.150270)

2015

• Beckett, M. C., Ralphs, J. R., Caterson, B. and Hayes, A. J. 2015. The transmembrane heparan sulphate proteoglycan syndecan-4 is involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc. European Cells and Materials 30, pp. 69-88.
• Stacey, O. J. et al. 2015. Water soluble, cyclometalated Pt(II)–Ln(III) conjugates towards novel bimodal imaging agents. Chemical Communications 51(61), pp. 12305-12308. (10.1039/C5CC02623G)
• Langdon-Jones, E. E. et al. 2015. Alkynyl-naphthalimide fluorophores: gold coordination chemistry and cellular imaging applications. Inorganic Chemistry 54(13), pp. 6606-6615., article number: 150618152106000. (10.1021/acs.inorgchem.5b00954)
• Lloyd, D., Lewis, I. B., Williams, C. F., Hayes, A. J., Symons, H. and Hill, E. C. 2015. Motility of the diplomonad fish parasite Spironucleus vortens through thixotropic solid media. Microbiology 161(1), pp. 213-218. (10.1099/mic.0.082529-0)

2014

• Boros-Majewska, J. et al. 2014. Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis. Medical Microbiology and Immunology 203(5), pp. 341-355. (10.1007/s00430-014-0343-4)
• Hayes, A. J., Gibson, M. A., Shu, C. and Melrose, J. 2014. Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix. Tissue and Cell 46(3), pp. 185-197. (10.1016/j.tice.2014.04.002)
• Sivan, S. S. et al. 2014. Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc. European Spine Journal 23(3), pp. 344-353. (10.1007/s00586-013-2767-8)
• Langdon-Jones, E. E. et al. 2014. Fluorescent rhenium-naphthalimide conjugates as cellular imaging agents. Inorganic Chemistry 53(7), pp. 3788-3797. (10.1021/ic500142z)
• Lloyd, D. et al. 2014. Intracellular oxygen: similar results from two methods of measurement using Phosphorescent nanoparticles. Journal of Innovative Optical Health Sciences 7(2), article number: 1350041. (10.1142/S1793545813500417)

2013

• Shu, C. et al. 2013. The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal 30(7), pp. 717-725. (10.1007/s10719-013-9475-9)
• Millet, C. O. M., Williams, C. F., Hayes, A. J., Hann, A. C., Cable, J. and Lloyd, D. 2013. Mitochondria-derived organelles in the diplomonad fish parasite Spironucleus vortens. Experimental Parasitology 135(2), pp. 262-273. (10.1016/j.exppara.2013.07.003)
• Hayes, A. J. et al. 2013. Spinal deformity in aged zebrafish Is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis. PLoS ONE 8(9), pp. e75787. (10.1371/journal.pone.0075787)
• Williams, C. F., Millet, C. O., Hayes, A. J., Cable, J. and Lloyd, D. 2013. Diversity in mitochondrion-derived organelles of the parasitic diplomonads Spironucleus and Giardia. Trends in Parasitology 29(7), pp. 311-312. (10.1016/j.pt.2013.04.004)
• Hayes, A. J., Mitchell, R. E., Bashford, A., Reynolds, S., Caterson, B. and Hammond, C. L. 2013. Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis. Developmental Dynamics 242(6), pp. 778-789. (10.1002/dvdy.23970)
• Li, S., Hayes, A. J., Caterson, B. and Hughes, C. E. 2013. The effect of beta-xylosides on the chondrogenic differentiation of mesenchymal stem cells. Histochemistry and Cell Biology 139(1), pp. 59-74. (10.1007/s00418-012-1017-1)
• Hayes, A. J., Smith, S. M. and Melrose, J. 2013. Comparative immunolocalisation of fibrillin-1 and perlecan in the human foetal, and HS-deficient hspg2 exon 3 null mutant mouse intervertebral disc. Histochemistry and Cell Biology 139(1), pp. 1-11. (10.1007/s00418-012-1041-1)

2012

• Hooper, S. J., Percival, S. L., Hill, K. E., Thomas, D. W., Hayes, A. J. and Williams, D. W. 2012. The visualisation and speed of kill of wound isolates on a silver alginate dressing. International Wound Journal 9(6), pp. 633-642. (10.1111/j.1742-481X.2012.00927.x)
• Melrose, J., Isaacs, M. D., Smith, S. M., Hughes, C. E., Little, C. B., Caterson, B. and Hayes, A. J. 2012. Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development. Histochemistry and Cell Biology 138(3), pp. 461-475. (10.1007/s00418-012-0968-6)
• Taylor, D. W., Ahmed, N., Hayes, A. J., Ferguson, P., Gross, A. E., Caterson, B. and Kandel, R. A. 2012. Hyaline cartilage tissue is formed through the co-culture of passaged human chondrocytes and primary bovine chondrocytes. Journal of Histochemistry & Cytochemistry 60(8), pp. 576-587. (10.1369/0022155412449018)

2011

• Parsons, P. et al. 2011. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
• Evans, L. C., Williams, A. S., Hayes, A. J., Jones, S. A. and Nowell, M. A. 2011. Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced arthritis. Arthritis and Rheumatism 63(7), pp. 1866-1877. (10.1002/art.30338)
• Evans, A., Williams, A. S., Hayes, A. J. and Nowell, M. A. 2011. Investigating the role of PBEF on cartilage integrity [Abstract]. International Journal of Experimental Pathology 92(3), pp. A33-A34. (10.1111/j.1365-2613.2010.00759.x)
• Hayes, A. J., Hughes, C. E., Ralphs, J. R. and Caterson, B. 2011. Chondroitin sulphate sulphation motif expression in the ontogeny of the intervertebral disc. European Cells and Materials 21, pp. 1-14.
• Akhtar, S., Bron, A., Hayes, A. J., Meek, K. M. A. and Caterson, B. 2011. Role of keratan sulphate (sulphated poly -N-acetyllactosamine repeats) in keratoconic cornea, histochemical, and ultrastructural analysis. Graefe's Archive for Clinical and Experimental Ophthalmology 249(3), pp. 413-420. (10.1007/s00417-010-1512-9)
• Thorp-Greenwood, F. L. et al. 2011. A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging. Chemical Communications 47(11), pp. 3096-3098. (10.1039/c1cc10141b)
• Hayes, A. J. and Ralphs, J. R. 2011. The response of foetal annulus fibrosus cells to growth factors: modulation of matrix synthesis by TGF-β1 and IGF-1. Histochemistry and Cell Biology 136(2), pp. 163-175. (10.1007/s00418-011-0835-x)
• Silva, S., Henriques, M. C., Hayes, A. J., Oliveira, R., Azeredo, J. and Williams, D. W. 2011. Candida glabrata and Candida albicans co-infection of an in vitro oral epithelium. Journal of Oral Pathology and Medicine 40(5), pp. 421-427. (10.1111/j.1600-0714.2010.00981.x)
• Hayes, A. J., Isaacs, M. D., Hughes, C. E., Caterson, B. and Ralphs, J. R. 2011. Collagen fibrillogenesis in the development of the annulus fibrosus of the intervertebral disc. European Cells and Materials 22, pp. 226-241.
• Hayes, A. J., Smith, S. M., Gibson, M. A. and Melrose, J. 2011. Comparative immunolocalization of the elastin fiber-associated proteins fibrillin-1, LTBP-2, and MAGP-1 With components of the collagenous and proteoglycan matrix of the fetal human intervertebral disc. Spine 36(21), pp. E1365-E1372. (10.1097/BRS.0b013e31821fd23e)
• Hayes, A. J., Lord, M. S., Smith, S. M., Smith, M. M., Whitelock, J. M., Weiss, A. S. and Melrose, J. 2011. Colocalization in vivo and association in vitro of perlecan and elastin. Histochemistry and Cell Biology 136(4), pp. 437-454. (10.1007/s00418-011-0854-7)

2010

• Coogan, M. P. et al. 2010. Probing intracellular oxygen by quenched phosphorescence lifetimes of nanoparticles containing polyacrylamide-embedded [Ru(dpp(SO3Na)2)3]Cl2. Photochemical and Photobiological Sciences 9(1), pp. 103-109. (10.1039/b9pp00071b)
• Ralphs, J. R., Caterson, B., Hughes, C. E. and Hayes, A. J. 2010. Chondroitin sulphate sulfation motifs in intervertebral disc development [Abstract]. European Cells and Materials 20(Supp 2), pp. 3.
• Fernández-Moreira, V. et al. 2010. Uptake and localisation of rhenium fac-tricarbonyl polypyridyls in fluorescent cell imaging experiments. Organic and Biomolecular Chemistry 8(17), pp. 3888-3901. (10.1039/c004610h)

2009

• Gealy, E. C., Hayes, A. J., Buckwell, R., Young, R. D., Caterson, B., Quantock, A. J. and Ralphs, J. R. 2009. Actin and type I collagen propeptide distribution in the developing chick cornea. Investigative Ophthalmology & Visual Science 50(4), pp. 1653 -1658. (10.1167/iovs.08-2554)
• Nowell, M. A. et al. 2009. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of Immunology 182(1), pp. 613-622.
• Malic, S., Hill, K. E., Hayes, A. J., Percival, S. L., Thomas, D. W. and Williams, D. W. 2009. Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH). Microbiology-Sgm 155, pp. 2603-2611. (10.1099/mic.0.028712-0)

2008

• Melrose, J., Hayes, A. J., Whitelock, J. M. and Little, C. B. 2008. Perlecan, the 'jack of all trades' proteoglycan of cartilaginous weight-bearing connective tissues. Bioessays 30(5), pp. 457-469. (10.1002/bies.20748)
• Hayes, A. J., Hughes, C. E. and Caterson, B. 2008. Antibodies and immunohistochemistry in extracellular matrix research. Methods 45(1), pp. 10-21. (10.1016/j.ymeth.2008.01.011)
• Caterson, B., Hayes, A. J., Tudor, D., Nowell, M. A. and Hughes, C. E. 2008. Chondroitin sulphate motifs as biomarkers for the stem/progenitor cell niche in musculoskeletal tissues. European Cells and Materials 16(Supp 2), pp. 47-47.
• Amoroso, A. J. et al. 2008. 3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria. New Journal of Chemistry 32(7), pp. 1097-1102. (10.1039/b802215a)
• Hayes, A. J., Tudor, D., Nowell, M. A., Caterson, B. and Hughes, C. E. 2008. Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells. Journal of Histochemistry & Cytochemistry 56(2), pp. 125-38. (10.1369/jhc.7A7320.2007)
• Akhtar, S., Kerr, B., Hayes, A. J., Hughes, C. E., Meek, K. M. and Caterson, B. 2008. Immunochemical localisation of keratan sulphate proteoglycans in cornea, sclera and limbus using a keratanase generated neoepitope monoclonal antibody. Investigative Ophthalmology and Visual Science 49(6), pp. 2424-2431. (10.1167/iovs.06-1498)
• Bazou, D., Coakley, W. T., Hayes, A. J. and Jackson, S. K. 2008. Long-term viability and proliferation of alginate-encapsulated 3-D HepG2 aggregates formed in an ultrasound trap. Toxicology in Vitro 22(5), pp. 1321-1331. (10.1016/j.tiv.2008.03.014)

2007

• Amoroso, A. J. et al. 2007. Rhenium fac tricarbonyl bisimine complexes: biologically useful fluorochromes for cell imaging applications. Chemical Communications(29), pp. 3066-3068. (10.1039/b706657k)
• Malic, S., Hill, K. E., Ralphs, J. R., Hayes, A. J., Thomas, D. W., Potts, A. J. C. and Williams, D. W. 2007. Characterisation of Candida albicans infection of an in vitro oral epithelial model using confocal laser scanning microscopy. Oral Microbiology And Immunolology 22(3), pp. 188-194. (10.1111/j.1399-302X.2007.00344.x)
• Aon, M. A., Cortassa, S., Lemar, K. M., Hayes, A. J. and Lloyd, D. 2007. Single and cell population respiratory oscillations in yeast: a 2-photon scanning laser microscopy study. FEBS Letters 581(1), pp. 8-14. (10.1016/j.febslet.2006.11.068)
• Gealy, E. C. et al. 2007. Differential expression of the keratan sulphate proteoglycan, keratocan, during chick corneal embryogenesis. Histochemistry and Cell Biology 128(6), pp. 551-555. (10.1007/s00418-007-0332-4)
• Hayes, A. J., Hall, A., Brown, L., Tubo, R. and Caterson, B. 2007. Macromolecular organization and in vitro growth characteristics of scaffold-free neocartilage grafts. Journal of Histochemistry & Cytochemistry 55(8), pp. 853-866. (10.1369/jhc.7A7210.2007)

2006

• Blain, E. J., Gilbert, S. J., Hayes, A. J. and Duance, V. C. 2006. Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis.. Matrix biology 25(7), pp. 398-408. (10.1016/j.matbio.2006.06.002)
• Reed, K. R., Sansom, O. J., Hayes, A. J., Gescher, A. J., Peters, J. M. and Clarke, A. R. 2006. PPARδ status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer 6(113) (10.1186/1471-2407-6-113)

2005

• Hall, A. K., Hayes, A. J., Brown, L., Tubo, R. and Caterson, B. 2005. Tissue-engineered cartilage grafts for use in cartilage repair technologies [Abstract]. International Journal of Experimental Pathology 86(3), pp. A9. (10.1111/j.0959-9673.2005.00426.x)
• Young, R. D. et al. 2005. Atypical composition and ultrastructure of proteoglycans in the mouse corneal stroma. Investigative Ophthalmology and Visual Science 46(6), pp. 1973-1978. (10.1167/iovs.04-1309)
• Hayes, A. J., Tudor, D., Nowell, M. A., Hughes, C. E. and Caterson, B. 2005. Novel chondroitin sulphation motifs as putative biomarkers of articular cartilage chondroprogenitor cells [Abstract]. European Cells and Materials 10(Supp 2), pp. 72.

2004

• Sansom, O. J. et al. 2004. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes and Development 18(12), pp. 1385-1390. (10.1101/gad.287404)
• Reed, K. R., Sansom, O. J., Hayes, A. J., Gescher, A. J., Winton, D. J., Peters, J. M. and Clarke, A. R. 2004. PPARδ status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene 23(55), pp. 8992-8996. (10.1038/sj.onc.1208143)

2003

• Hayes, A. J., Dowthwaite, G. P., Webster, S. V. and Archer, C. W. 2003. The distribution of Notch receptors and their ligands during articular cartilage development. Journal of Anatomy 202(6), pp. 495-502. (10.1046/j.1469-7580.2003.00185.x)

2001

• Hayes, A., MacPherson, S., Morrison, H., Dowthwaite, G. and Archer, C. 2001. The development of articular cartilage: Evidence for an appositional growth mechanism. Anatomy and Embryology 203(6), pp. 469-479. (10.1007/s004290100178)
• Hayes, A. J., Benjamin, M. and Ralphs, J. R. 2001. Extracellular matrix in development of the intervertebral disc. Matrix Biology 20(2), pp. 107-121. (10.1016/S0945-053X(01)00125-1)

1999

• Hayes, A. J., Benjamin, M. and Ralphs, J. R. 1999. Role of actin stress fibres in the development of the intervertebral disc: cytoskeletal control of extracellular matrix assembly. Developmental Dynamics 215(3), pp. 179-189. (10.1002/(SICI)1097-0177(199907)215:3<179::AID-AJA1>3.0.CO;2-Q)
• Lloyd, D., Hayes, A. J. and Ralphs, J. R. 1999. Confocal laser scanning microscopy of environmental samples. In: Edwards, C. ed. Environmental Monitoring of Bacteria., Vol. 12. USA: Springer, pp. 251-265., (10.1385/0-89603-566-2:251)
• Williams, I. et al. 1999. Flow cytometry and other techniques show that Staphylococcus aureus undergoes significant physiological changes in the early stages of surface-attached culture. Microbiology 145(6), pp. 1325-1333. (10.1099/13500872-145-6-1325)

1998

• Shnyder, S. D., Hayes, A., Pringle, J. and Archer, C. 1998. P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma. British Journal of Cancer 78, pp. 757-759. (10.1038/bjc.1998.573)
• Lloyd, D. et al. 1998. Micro-ecology of peat: minimally invasive analysis using confocal laser scanning microscopy, membrane inlet mass spectrometry and PCR amplification of methanogen-specific gene sequences. FEMS Microbiology Ecology 25(2), pp. 179-188. (10.1016/S0168-6496(97)00094-9)

1997

• Hayes, A. J., Ralphs, J. R. and Benjamin, M. 1997. The involvement of actin in annulus formation in the rat lumbar intervertebral disc. Journal of Anatomy 191(1), pp. 125.
• Biagini, G. A., Hayes, A. J., Suller, M. T. E., Winters, C., Finlay, B. J. and Archer, C. W. 1997. Hydrogenosomes of metopus contortus physiologically resemble mitochondria. Microbiology 143(5), pp. 1623-1629. (10.1099/00221287-143-5-1623)

1996

• Lloyd, D., Moran, C. A., Suller, M. T. E., Dinsdale, M. G. and Hayes, A. J. 1996. Flow cytometric monitoring of rhodamine 123 and a cyanine dye uptake by yeast during cider fermentation. Journal of the Institute of Brewing 102(4), pp. 251-259. (10.1002/j.2050-0416.1996.tb00910.x)
• Lloyd, D., Williams, A. G., Amann, R., Hayes, A. J., Durrant, L. and Ralphs, J. R. 1996. Intracellular prokaryotes in rumen ciliate protozoa: detection by confocal laser scanning microscopy after in situ hybridization with fluorescent 16S rRNA probes. European Journal of Protistology 32(4), pp. 523-531. (10.1016/S0932-4739(96)80011-3)

1995

• Lloyd, D. and Hayes, A. J. 1995. Vigour, vitality and viability of microorganisms. FEMS Microbiology Letters 133(1-2), pp. 1-7. (10.1111/j.1574-6968.1995.tb07852.x)