![Lucy Hiscox](https://profiles-cardiff.imgix.net/attachments/8652?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Lucy Hiscox
(hi/ei)
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Lucy Hiscox
Cymrawd Ymddiriedolaeth Wellcome
Trosolwyg
Mae gen i ddiddordeb mewn defnyddio technegau niwroddelweddu datblygedig i wella ein dealltwriaeth o'r mecanweithiau y tu ôl i ddatblygu cyflyrau niwroddirywiol fel clefyd Alzheimer. Mae'r rhan fwyaf o'm hymchwil wedi cynnwys cymhwyso elastograffeg cyseiniant magnetig (MRE) i fesur priodweddau mecanyddol yr ymennydd yn anfewnwthiol ac yn vivo. Mae MRE yn sensitif iawn i iechyd microstrwythur meinweoedd, lle mae meinwe yn meddalu'r hippocampus yn aml yn cael ei arsylwi mewn clefyd Alzheimer, a mwy o gludedd hippocampal sy'n gysylltiedig â pherfformiad gwaeth mewn tasgau gwybyddol. Yn ogystal, rydym ond yn dechrau sylweddoli effaith mecaneg meinwe ar systemau biolegol a chemegol eraill, ac efallai y byddwn mewn gwirionedd yn chwarae rôl achosol wrth ddatblygu clefydau penodol.
Cyhoeddiad
2026
- Hiscox, L. et al. 2026. 88 Slip interface imaging in glioblastoma: a pilot study of tumour-brain adhesion and surgical resectability [Abstract]. Neuro-Oncology 28 (S1) noag172.029. (10.1093/neuonc/noag172.029)
- Golten, J. et al. 2026. 20 Updates on Magnetic Resonance Imaging assessment of tumour MicrOStructure in GlioblastomA: A cross-sectional study (The MIMOSA Study) [Abstract]. Neuro-Oncology 28 (S1) noag172.058. (10.1093/neuonc/noag172.058)
- Davis, R. et al. 2026. Impact of apolipoprotein Ε4 (APOE ε4) on neuroimaging outcomes in cognitively healthy midlife adults: A systematic review. NeuroImage: Clinical 51 104035. (10.1016/j.nicl.2026.104035)
- Tuominen, J. et al., 2026. 0058 Brain viscoelastic properties predict distinct domains of sleep quality [Abstract]. SLEEP 49 (S1) A26. (10.1093/sleep/zsag091.0058)
- Tsunga, L. et al., 2026. Violence exposure and cognitive outcomes among children in Low-Middle Income Countries (LMICs): A systematic review. Trauma, Violence, and Abuse 27 (2), pp.407-428. (10.1177/15248380251316232)
- Sharp, T. H. et al., 2026. Prospective biomarkers of posttraumatic stress disorder in children and adolescents: a systematic review and meta-analysis. Translational Psychiatry 16 (1) 217. (10.1038/s41398-026-03939-1)
2025
- Träuble, J. et al., 2025. Brain age prediction and early neurodegeneration detection using contrastive learning on brain biomechanics: a retrospective, multicentre study. EBioMedicine 121 105996. (10.1016/j.ebiom.2025.105996)
- Twohy, K. E. et al., 2025. Mechanical properties of the cortex in older adults and relationships with personality traits. Human Brain Mapping 46 (2) e70147. (10.1002/hbm.70147)
- Hiscox, L. V. et al. 2025. MR elastography reveals lower hippocampal stiffness in middle-aged APOE ε4 carriers without cognitive impairment. Presented at: International Society for Magnetic Resonance in Medicine (ISMRM) Hawaii, USA. 10-15 May 2025. Proceedings of the International Society for Magnetic Resonance in Medicine - Scientific Meeting and Exhibition. , pp.0791. (10.58530/2025/0791)
2024
- Träuble, J. et al., 2024. Contrastive learning with adaptive neighborhoods for brain age prediction on 3D stiffness maps. Transactions on Machine Learning Research
- McIlvain, G. et al., 2024. Acute effects of high-intensity exercise on brain mechanical properties and cognitive function. Brain Imaging and Behavior 18 , pp.863-874. (10.1007/s11682-024-00873-y)
- Träuble, J. et al., 2024. Adaptive neighborhoods in contrastive regression learning for brain age prediction. Presented at: NeurIPS 2024 Workshop: Self-Supervised Learning - Theory and Practice Vancouver, Canada 09 - 15 December 2024.
2023
- Sanjana, F. et al., 2023. Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan. Journal of Cerebral Blood Flow & Metabolism 43 (11), pp.1931-1941. (10.1177/0271678X231186571)
- Tinney, E. M. et al., 2023. Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging. Psychophysiology 60 (9) e14306. (10.1111/psyp.14306)
- Hiscox, L. V. et al. 2023. Sex-based contributors to and consequences of post-traumatic stress disorder. Current Psychiatry Reports 25 , pp.233-245. (10.1007/s11920-023-01421-z)
- Hiscox, L. V. et al. 2023. Sex differences in the severity and natural recovery of child PTSD symptoms: a longitudinal analysis of children exposed to acute trauma. Psychological Medicine 53 (6), pp.2682-2688. (10.1017/S0033291721004694)
- Hiscox, L. V. et al. 2023. Antenatal maternal intimate partner violence exposure is associated with sex-specific alterations in brain structure among young infants: Evidence from a South African birth cohort. Developmental Cognitive Neuroscience 60 101210. (10.1016/j.dcn.2023.101210)
- Delgorio, P. L. et al., 2023. Hippocampal subfield viscoelasticity in amnestic mild cognitive impairment evaluated with MR elastography. NeuroImage: Clinical 37 103327. (10.1016/j.nicl.2023.103327)
2022
- Delgorio, P. L. et al., 2022. Structure–function dissociations of human hippocampal subfield stiffness and memory performance. The Journal of Neuroscience 42 (42), pp.7957-7968. (10.1523/jneurosci.0592-22.2022)
- Hope, C. et al., 2022. Examining harmful impacts of the COVID‐19 pandemic and school closures on parents and carers in the United Kingdom: A rapid review. JCPP Advances 2 (3) e12095. (10.1002/jcv2.12095)
- Diamond, P. R. et al., 2022. Change in prevalence of post-traumatic stress disorder in the two years following trauma: a meta-analytic study. European Journal of Psychotraumatology 13 (1) 2066456. (10.1080/20008198.2022.2066456)
- Hiscox, L. V. , McGarry, M. D. J. and Johnston, C. L. 2022. Evaluation of cerebral cortex viscoelastic property estimation with nonlinear inversion magnetic resonance elastography. Physics in Medicine & Biology 67 095002. (10.1088/1361-6560/ac5fde)
2021
- Hiscox, L. V. et al. 2021. Sex differences in post-traumatic stress disorder in a high adversity cohort of South African adolescents: an examination of depressive symptoms, age, and trauma type as explanatory factors. European Journal of Psychotraumatology 12 (1) 1978669. (10.1080/20008198.2021.1978669)
- Delgorio, P. L. et al., 2021. Effect of aging on the viscoelastic properties of hippocampal subfields assessed with high-resolution MR elastography. Cerebral Cortex 31 (6), pp.2799-2811. (10.1093/cercor/bhaa388)
- Sanjana F, F. et al., 2021. Blood lipid markers are associated with hippocampal viscoelastic properties and memory in humans. Journal of Cerebral Blood Flow and Metabolism 41 (6), pp.1417-1427. (10.1177/0271678x20968032)
- Hiscox, L. V. et al. 2021. Aging brain mechanics: Progress and promise of magnetic resonance elastography. NeuroImage 232 117889. (10.1016/j.neuroimage.2021.117889)
- Giudice, J. S. et al., 2021. Calibration of a heterogeneous brain model using a subject-specific inverse finite element approach. Frontiers in Bioengineering and Biotechnology 9 664268. (10.3389/fbioe.2021.664268)
2020
- Hiscox, L. V. et al. 2020. Standard-space atlas of the viscoelastic properties of the human brain. Human Brain Mapping 41 (18), pp.5282-5300. (10.1002/hbm.25192)
2019
- Hiscox, L. V. et al. 2019. Mechanical property alterations across the cerebral cortex due to Alzheimer’s disease. Brain Communications 2 (1), pp.16. (10.1093/braincomms/fcz049)
- Rzechorzek, N. M. et al., 2019. Network analysis of canine brain morphometry links tumour risk to oestrogen deficiency and accelerated brain ageing. Scientific Reports 9 12506. (10.1038/s41598-019-48446-0)
2018
- Hiscox, L. V. et al. 2018. Hippocampal viscoelasticity and episodic memory performance in healthy older adults examined with magnetic resonance elastography. Brain Imaging and Behavior 14 (1), pp.175-185. (10.1007/s11682-018-9988-8)
- Hiscox, L. V. et al. 2018. High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults. Neurobiology of Aging 65 , pp.158-167. (10.1016/j.neurobiolaging.2018.01.010)
2016
- Hiscox, L. V. et al. 2016. Magnetic resonance elastography (MRE) of the human brain: technique, findings and clinical applications. Physics in Medicine & Biology 61 (24), pp.R401-R437. (10.1088/0031-9155/61/24/r401)
2014
- Hiscox, L. , Leonaviciute, E. and Humby, T. 2014. The effects of automatic spelling correction software on understanding and comprehension in compensated dyslexia: improved recall following dictation. Dyslexia 20 (3), pp.208-224. (10.1002/dys.1480)
2012
- FeldmanHall, O. et al., 2012. What we say and what we do: the relationship between real and hypothetical moral choices. Cognition 123 (3), pp.434-441. (10.1016/j.cognition.2012.02.001)
Articles
- Hiscox, L. et al. 2026. 88 Slip interface imaging in glioblastoma: a pilot study of tumour-brain adhesion and surgical resectability [Abstract]. Neuro-Oncology 28 (S1) noag172.029. (10.1093/neuonc/noag172.029)
- Golten, J. et al. 2026. 20 Updates on Magnetic Resonance Imaging assessment of tumour MicrOStructure in GlioblastomA: A cross-sectional study (The MIMOSA Study) [Abstract]. Neuro-Oncology 28 (S1) noag172.058. (10.1093/neuonc/noag172.058)
- Davis, R. et al. 2026. Impact of apolipoprotein Ε4 (APOE ε4) on neuroimaging outcomes in cognitively healthy midlife adults: A systematic review. NeuroImage: Clinical 51 104035. (10.1016/j.nicl.2026.104035)
- Tuominen, J. et al., 2026. 0058 Brain viscoelastic properties predict distinct domains of sleep quality [Abstract]. SLEEP 49 (S1) A26. (10.1093/sleep/zsag091.0058)
- Tsunga, L. et al., 2026. Violence exposure and cognitive outcomes among children in Low-Middle Income Countries (LMICs): A systematic review. Trauma, Violence, and Abuse 27 (2), pp.407-428. (10.1177/15248380251316232)
- Sharp, T. H. et al., 2026. Prospective biomarkers of posttraumatic stress disorder in children and adolescents: a systematic review and meta-analysis. Translational Psychiatry 16 (1) 217. (10.1038/s41398-026-03939-1)
- Träuble, J. et al., 2025. Brain age prediction and early neurodegeneration detection using contrastive learning on brain biomechanics: a retrospective, multicentre study. EBioMedicine 121 105996. (10.1016/j.ebiom.2025.105996)
- Twohy, K. E. et al., 2025. Mechanical properties of the cortex in older adults and relationships with personality traits. Human Brain Mapping 46 (2) e70147. (10.1002/hbm.70147)
- Träuble, J. et al., 2024. Contrastive learning with adaptive neighborhoods for brain age prediction on 3D stiffness maps. Transactions on Machine Learning Research
- McIlvain, G. et al., 2024. Acute effects of high-intensity exercise on brain mechanical properties and cognitive function. Brain Imaging and Behavior 18 , pp.863-874. (10.1007/s11682-024-00873-y)
- Sanjana, F. et al., 2023. Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan. Journal of Cerebral Blood Flow & Metabolism 43 (11), pp.1931-1941. (10.1177/0271678X231186571)
- Tinney, E. M. et al., 2023. Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging. Psychophysiology 60 (9) e14306. (10.1111/psyp.14306)
- Hiscox, L. V. et al. 2023. Sex-based contributors to and consequences of post-traumatic stress disorder. Current Psychiatry Reports 25 , pp.233-245. (10.1007/s11920-023-01421-z)
- Hiscox, L. V. et al. 2023. Sex differences in the severity and natural recovery of child PTSD symptoms: a longitudinal analysis of children exposed to acute trauma. Psychological Medicine 53 (6), pp.2682-2688. (10.1017/S0033291721004694)
- Hiscox, L. V. et al. 2023. Antenatal maternal intimate partner violence exposure is associated with sex-specific alterations in brain structure among young infants: Evidence from a South African birth cohort. Developmental Cognitive Neuroscience 60 101210. (10.1016/j.dcn.2023.101210)
- Delgorio, P. L. et al., 2023. Hippocampal subfield viscoelasticity in amnestic mild cognitive impairment evaluated with MR elastography. NeuroImage: Clinical 37 103327. (10.1016/j.nicl.2023.103327)
- Delgorio, P. L. et al., 2022. Structure–function dissociations of human hippocampal subfield stiffness and memory performance. The Journal of Neuroscience 42 (42), pp.7957-7968. (10.1523/jneurosci.0592-22.2022)
- Hope, C. et al., 2022. Examining harmful impacts of the COVID‐19 pandemic and school closures on parents and carers in the United Kingdom: A rapid review. JCPP Advances 2 (3) e12095. (10.1002/jcv2.12095)
- Diamond, P. R. et al., 2022. Change in prevalence of post-traumatic stress disorder in the two years following trauma: a meta-analytic study. European Journal of Psychotraumatology 13 (1) 2066456. (10.1080/20008198.2022.2066456)
- Hiscox, L. V. , McGarry, M. D. J. and Johnston, C. L. 2022. Evaluation of cerebral cortex viscoelastic property estimation with nonlinear inversion magnetic resonance elastography. Physics in Medicine & Biology 67 095002. (10.1088/1361-6560/ac5fde)
- Hiscox, L. V. et al. 2021. Sex differences in post-traumatic stress disorder in a high adversity cohort of South African adolescents: an examination of depressive symptoms, age, and trauma type as explanatory factors. European Journal of Psychotraumatology 12 (1) 1978669. (10.1080/20008198.2021.1978669)
- Delgorio, P. L. et al., 2021. Effect of aging on the viscoelastic properties of hippocampal subfields assessed with high-resolution MR elastography. Cerebral Cortex 31 (6), pp.2799-2811. (10.1093/cercor/bhaa388)
- Sanjana F, F. et al., 2021. Blood lipid markers are associated with hippocampal viscoelastic properties and memory in humans. Journal of Cerebral Blood Flow and Metabolism 41 (6), pp.1417-1427. (10.1177/0271678x20968032)
- Hiscox, L. V. et al. 2021. Aging brain mechanics: Progress and promise of magnetic resonance elastography. NeuroImage 232 117889. (10.1016/j.neuroimage.2021.117889)
- Giudice, J. S. et al., 2021. Calibration of a heterogeneous brain model using a subject-specific inverse finite element approach. Frontiers in Bioengineering and Biotechnology 9 664268. (10.3389/fbioe.2021.664268)
- Hiscox, L. V. et al. 2020. Standard-space atlas of the viscoelastic properties of the human brain. Human Brain Mapping 41 (18), pp.5282-5300. (10.1002/hbm.25192)
- Hiscox, L. V. et al. 2019. Mechanical property alterations across the cerebral cortex due to Alzheimer’s disease. Brain Communications 2 (1), pp.16. (10.1093/braincomms/fcz049)
- Rzechorzek, N. M. et al., 2019. Network analysis of canine brain morphometry links tumour risk to oestrogen deficiency and accelerated brain ageing. Scientific Reports 9 12506. (10.1038/s41598-019-48446-0)
- Hiscox, L. V. et al. 2018. Hippocampal viscoelasticity and episodic memory performance in healthy older adults examined with magnetic resonance elastography. Brain Imaging and Behavior 14 (1), pp.175-185. (10.1007/s11682-018-9988-8)
- Hiscox, L. V. et al. 2018. High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults. Neurobiology of Aging 65 , pp.158-167. (10.1016/j.neurobiolaging.2018.01.010)
- Hiscox, L. V. et al. 2016. Magnetic resonance elastography (MRE) of the human brain: technique, findings and clinical applications. Physics in Medicine & Biology 61 (24), pp.R401-R437. (10.1088/0031-9155/61/24/r401)
- Hiscox, L. , Leonaviciute, E. and Humby, T. 2014. The effects of automatic spelling correction software on understanding and comprehension in compensated dyslexia: improved recall following dictation. Dyslexia 20 (3), pp.208-224. (10.1002/dys.1480)
- FeldmanHall, O. et al., 2012. What we say and what we do: the relationship between real and hypothetical moral choices. Cognition 123 (3), pp.434-441. (10.1016/j.cognition.2012.02.001)
Conferences
- Hiscox, L. V. et al. 2025. MR elastography reveals lower hippocampal stiffness in middle-aged APOE ε4 carriers without cognitive impairment. Presented at: International Society for Magnetic Resonance in Medicine (ISMRM) Hawaii, USA. 10-15 May 2025. Proceedings of the International Society for Magnetic Resonance in Medicine - Scientific Meeting and Exhibition. , pp.0791. (10.58530/2025/0791)
- Träuble, J. et al., 2024. Adaptive neighborhoods in contrastive regression learning for brain age prediction. Presented at: NeurIPS 2024 Workshop: Self-Supervised Learning - Theory and Practice Vancouver, Canada 09 - 15 December 2024.
Bywgraffiad
- PhD, Niwrowyddoniaeth Glinigol, Prifysgol Caeredin, y DU. Ariannwyd gan Alzheimer Scotland (2014 - 2018).
- Baglor mewn Gwyddoniaeth, Seicoleg Gymhwysol (dosbarth 1af), Prifysgol Caerdydd, DU (2008 - 2012).
Anrhydeddau a dyfarniadau
- Gwobr Gyrfa Gynnar Ymddiriedolaeth Wellcome. " Mecanobioleg clefyd Alzheimer cyn-glinigol" (2023 - 2028).
- Gwobr Gyrfa Gynnar Seren Rising gan SINAPSE - Scottish Imaging Network (2021).
Aelodaethau proffesiynol
- ISTAART Aelodaeth Proffesiynol (Cymdeithas Ryngwladol Alzheimer's Association i hyrwyddo ymchwil a thriniaeth Alzheimer).
- Aelod o Grŵp Arbenigol Wellcome ym Mhrifysgol Caerdydd.
- Adolygydd Gwyddonydd ar gyfer Pwyllgor Adolygu Banc Bio Prifysgol Caerdydd.
- Aelod o'r Gymdeithas Ryngwladol ar gyfer Cyseiniant Magnetig mewn Meddygaeth (ISMRM).
- Cynrychiolydd dan hyfforddiant Grŵp Astudio MRE ISMRM (2019 - 2020).
Safleoedd academaidd blaenorol
- Cydymaith Ymchwil Ôl-ddoethurol; Adran Seicoleg, Prifysgol Caerfaddon, Y Deyrnas Unedig (2020 - 2023).
- Cydymaith Ymchwil Ôl-ddoethurol; Peirianneg Biofeddygol, Prifysgol Delaware, Unol Daleithiau (2018 - 2020).
Ymrwymiadau siarad cyhoeddus
Sgyrsiau gwahoddedig
- Symposiwm Archwilio Mecaneg yr Ymennydd yn Sefydliad Max Planck ar gyfer Gwyddoniaeth Golau; Erlangen, Yr Almaen (Medi 2025). Sgwrs o'r enw: Mecaneg Meinwe'r Ymennydd mewn Dementia: Mewnwelediadau o Elastograffeg Cyseiniant Magnetig (MRE).
- Gweithdy Data Ymennydd Dehongladwy (IBD) yn Sefydliad Technoleg Brenhinol KTH; Stockholm, Sweden (2023).
- Sesiwn addysgol ISMRM ar "Cnau a Bolltau Elastograffeg MR yn yr Ymennydd" yn ystod y cwrs: "Offer Newydd i'r Niwroradiolegydd"; Llundain (2022).
- SINAPSE ASM (Cyfarfod Gwyddonol Blynyddol Rhwydwaith Delweddu'r Alban); Glasgow (2021).
- Cynhadledd Flynyddol Alzheimer Scotland; Ar-lein (2021).
- Cymdeithas Ryngwladol Cyseiniant Magnetig mewn Meddygaeth (ISMRM); Montreal, Canada (2019).
Pwyllgorau ac adolygu
adolygydd cyfnodolion
• Delweddu Niwrowyddoniaeth • Cyfathrebu'r ymennydd • NeuroImage • Neuroimage: Clinigol • Ffocws Rhyngwyneb • Ffiniau mewn Biobeirianneg a Biotechnoleg • Ffiniau mewn Niwrowyddoniaeth Dynol • Journal of Neuroimaging • Mapio Ymennydd Dynol • Cyfnodolyn Ymddygiad Mecanyddol Deunyddiau Biofeddygol • ActaBiomaterialia • Adroddiadau Gwyddonol.
Golygydd Adolygiad
• Niwrowyddoniaeth Drosiadol • Ffiniau mewn Heneiddio Niwrowyddoniaeth
Meysydd goruchwyliaeth
- Clefydau niwroddirywiol
- Delweddu Cyseiniant Magnetig
- Elastograffi
Goruchwyliaeth gyfredol
Contact Details
[email protected]
+44 29208 74000 ext 20054
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Ystafell 1.031, Heol Maendy, Caerdydd, CF24 4HQ
+44 29208 74000 ext 20054
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Ystafell 1.031, Heol Maendy, Caerdydd, CF24 4HQ
Themâu ymchwil
Arbenigeddau
- Elastograffi
- Clefyd niwroddirywiol
- Niwroddelweddu
- MRI
- Mecaneg meinwe