![Lucy Hiscox](https://profiles-cardiff.imgix.net/attachments/4448?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Lucy Hiscox
(hi/ei)
Cymrawd Ymddiriedolaeth Wellcome
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Mae gen i ddiddordeb mewn defnyddio technegau niwroddelweddu datblygedig i wella ein dealltwriaeth o'r mecanweithiau y tu ôl i ddatblygu cyflyrau niwroddirywiol fel clefyd Alzheimer. Mae'r rhan fwyaf o'm hymchwil wedi cynnwys cymhwyso elastograffeg cyseiniant magnetig (MRE) i fesur priodweddau mecanyddol yr ymennydd yn anfewnwthiol ac yn vivo. Mae MRE yn sensitif iawn i iechyd microstrwythur meinweoedd, lle mae meinwe yn meddalu'r hippocampus yn aml yn cael ei arsylwi mewn clefyd Alzheimer, a mwy o gludedd hippocampal sy'n gysylltiedig â pherfformiad gwaeth mewn tasgau gwybyddol. Yn ogystal, rydym ond yn dechrau sylweddoli effaith mecaneg meinwe ar systemau biolegol a chemegol eraill, ac efallai y byddwn mewn gwirionedd yn chwarae rôl achosol wrth ddatblygu clefydau penodol.
Cyhoeddiad
2024
- Träuble, J., Hiscox, L. V., Johnson, C. L., Schönlieb, C., Kaminski Schierle, G. S. and Aviles-Rivero, A. I. 2024. Contrastive learning with adaptive neighborhoods for brain age prediction on 3D stiffness maps. Transactions on Machine Learning Research
- McIlvain, G., Magoon, E. M., Clements, R. G., Merritt, A., Hiscox, L. V., Schwarb, H. and Johnson, C. L. 2024. Acute effects of high-intensity exercise on brain mechanical properties and cognitive function. Brain Imaging and Behavior 18, pp. 863-874. (10.1007/s11682-024-00873-y)
- Träuble, J., Hiscox, L. V., Johnson, C. L., Schönlieb, C., Kaminski Schierle, G. S. and Aviles-Rivero, A. I. 2024. Adaptive neighborhoods in contrastive regression learning for brain age prediction. Presented at: NeurIPS 2024 Workshop: Self-Supervised Learning - Theory and Practice, Vancouver, Canada, 09 - 15 December 2024.
2023
- Sanjana, F., Delgorio, P. L., DeConne, T. M., Hiscox, L. V., Pohlig, R. T., Johnson, C. L. and Martens, C. R. 2023. Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan. Journal of Cerebral Blood Flow & Metabolism 43(11), pp. 1931-1941. (10.1177/0271678X231186571)
- Tinney, E. M. et al. 2023. Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging. Psychophysiology 60(9), article number: e14306. (10.1111/psyp.14306)
- Hiscox, L. V., Sharp, T. H., Olff, M., Seedat, S. and Halligan, S. L. 2023. Sex-based contributors to and consequences of post-traumatic stress disorder. Current Psychiatry Reports 25, pp. 233-245. (10.1007/s11920-023-01421-z)
- Hiscox, L. V., Bray, S., Fraser, A., Meiser-Stedman, R., Seedat, S. and Halligan, S. L. 2023. Sex differences in the severity and natural recovery of child PTSD symptoms: a longitudinal analysis of children exposed to acute trauma. Psychological Medicine 53(6), pp. 2682-2688. (10.1017/S0033291721004694)
- Hiscox, L. V. et al. 2023. Antenatal maternal intimate partner violence exposure is associated with sex-specific alterations in brain structure among young infants: Evidence from a South African birth cohort. Developmental Cognitive Neuroscience 60, article number: 101210. (10.1016/j.dcn.2023.101210)
- Delgorio, P. L. et al. 2023. Hippocampal subfield viscoelasticity in amnestic mild cognitive impairment evaluated with MR elastography. NeuroImage: Clinical 37, article number: 103327. (10.1016/j.nicl.2023.103327)
2022
- Delgorio, P. L. et al. 2022. Structure–function dissociations of human hippocampal subfield stiffness and memory performance. The Journal of Neuroscience 42(42), pp. 7957-7968. (10.1523/jneurosci.0592-22.2022)
- Hope, C., Hiscox, L. V., Halligan, S. L. and Creswell, C. 2022. Examining harmful impacts of the COVID‐19 pandemic and school closures on parents and carers in the United Kingdom: A rapid review. JCPP Advances 2(3), article number: e12095. (10.1002/jcv2.12095)
- Diamond, P. R., Airdrie, J. N., Hiller, R., Fraser, A., Hiscox, L. V., Hamilton-Giachritsis, C. and Halligan, S. L. 2022. Change in prevalence of post-traumatic stress disorder in the two years following trauma: a meta-analytic study. European Journal of Psychotraumatology 13(1), article number: 2066456. (10.1080/20008198.2022.2066456)
- Hiscox, L. V., McGarry, M. D. J. and Johnston, C. L. 2022. Evaluation of cerebral cortex viscoelastic property estimation with nonlinear inversion magnetic resonance elastography. Physics in Medicine & Biology 67, article number: 95002. (10.1088/1361-6560/ac5fde)
2021
- Hiscox, L. V. et al. 2021. Sex differences in post-traumatic stress disorder in a high adversity cohort of South African adolescents: an examination of depressive symptoms, age, and trauma type as explanatory factors. European Journal of Psychotraumatology 12(1), article number: 1978669. (10.1080/20008198.2021.1978669)
- Delgorio, P. L. et al. 2021. Effect of aging on the viscoelastic properties of hippocampal subfields assessed with high-resolution MR elastography. Cerebral Cortex 31(6), pp. 2799-2811. (10.1093/cercor/bhaa388)
- Sanjana F, F. et al. 2021. Blood lipid markers are associated with hippocampal viscoelastic properties and memory in humans. Journal of Cerebral Blood Flow and Metabolism 41(6), pp. 1417-1427. (10.1177/0271678x20968032)
- Hiscox, L. V., Schwarb, H., McGarry, M. D. and Johnson, C. L. 2021. Aging brain mechanics: Progress and promise of magnetic resonance elastography. NeuroImage 232, article number: 117889. (10.1016/j.neuroimage.2021.117889)
- Giudice, J. S., Alshareef, A., Wu, T., Knutsen, A. K., Hiscox, L. V., Johnson, C. L. and Panzer, M. B. 2021. Calibration of a heterogeneous brain model using a subject-specific inverse finite element approach. Frontiers in Bioengineering and Biotechnology 9, article number: 664268. (10.3389/fbioe.2021.664268)
2020
- Hiscox, L. V. et al. 2020. Standard-space atlas of the viscoelastic properties of the human brain. Human Brain Mapping 41(18), pp. 5282-5300. (10.1002/hbm.25192)
2019
- Hiscox, L. V. et al. 2019. Mechanical property alterations across the cerebral cortex due to Alzheimer’s disease. Brain Communications 2(1), pp. 16. (10.1093/braincomms/fcz049)
- Rzechorzek, N. M. et al. 2019. Network analysis of canine brain morphometry links tumour risk to oestrogen deficiency and accelerated brain ageing. Scientific Reports 9, article number: 12506. (10.1038/s41598-019-48446-0)
2018
- Hiscox, L. V., Johnson, C. L., McGarry, M. D. J., Schwarb, H., Van Beek, E. J. R., Roberts, N. and Starr, J. M. 2018. Hippocampal viscoelasticity and episodic memory performance in healthy older adults examined with magnetic resonance elastography. Brain Imaging and Behavior 14(1), pp. 175-185. (10.1007/s11682-018-9988-8)
- Hiscox, L. V. et al. 2018. High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults. Neurobiology of Aging 65, pp. 158-167. (10.1016/j.neurobiolaging.2018.01.010)
2016
- Hiscox, L. V. et al. 2016. Magnetic resonance elastography (MRE) of the human brain: technique, findings and clinical applications. Physics in Medicine & Biology 61(24), pp. R401-R437. (10.1088/0031-9155/61/24/r401)
2014
- Hiscox, L., Leonaviciute, E. and Humby, T. 2014. The effects of automatic spelling correction software on understanding and comprehension in compensated dyslexia: improved recall following dictation. Dyslexia 20(3), pp. 208-224. (10.1002/dys.1480)
2012
- FeldmanHall, O., Mobbs, D., Evans, D., Hiscox, L., Navrady, L. and Dalgleish, T. 2012. What we say and what we do: the relationship between real and hypothetical moral choices. Cognition 123(3), pp. 434-441. (10.1016/j.cognition.2012.02.001)
Articles
- Träuble, J., Hiscox, L. V., Johnson, C. L., Schönlieb, C., Kaminski Schierle, G. S. and Aviles-Rivero, A. I. 2024. Contrastive learning with adaptive neighborhoods for brain age prediction on 3D stiffness maps. Transactions on Machine Learning Research
- McIlvain, G., Magoon, E. M., Clements, R. G., Merritt, A., Hiscox, L. V., Schwarb, H. and Johnson, C. L. 2024. Acute effects of high-intensity exercise on brain mechanical properties and cognitive function. Brain Imaging and Behavior 18, pp. 863-874. (10.1007/s11682-024-00873-y)
- Sanjana, F., Delgorio, P. L., DeConne, T. M., Hiscox, L. V., Pohlig, R. T., Johnson, C. L. and Martens, C. R. 2023. Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan. Journal of Cerebral Blood Flow & Metabolism 43(11), pp. 1931-1941. (10.1177/0271678X231186571)
- Tinney, E. M. et al. 2023. Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging. Psychophysiology 60(9), article number: e14306. (10.1111/psyp.14306)
- Hiscox, L. V., Sharp, T. H., Olff, M., Seedat, S. and Halligan, S. L. 2023. Sex-based contributors to and consequences of post-traumatic stress disorder. Current Psychiatry Reports 25, pp. 233-245. (10.1007/s11920-023-01421-z)
- Hiscox, L. V., Bray, S., Fraser, A., Meiser-Stedman, R., Seedat, S. and Halligan, S. L. 2023. Sex differences in the severity and natural recovery of child PTSD symptoms: a longitudinal analysis of children exposed to acute trauma. Psychological Medicine 53(6), pp. 2682-2688. (10.1017/S0033291721004694)
- Hiscox, L. V. et al. 2023. Antenatal maternal intimate partner violence exposure is associated with sex-specific alterations in brain structure among young infants: Evidence from a South African birth cohort. Developmental Cognitive Neuroscience 60, article number: 101210. (10.1016/j.dcn.2023.101210)
- Delgorio, P. L. et al. 2023. Hippocampal subfield viscoelasticity in amnestic mild cognitive impairment evaluated with MR elastography. NeuroImage: Clinical 37, article number: 103327. (10.1016/j.nicl.2023.103327)
- Delgorio, P. L. et al. 2022. Structure–function dissociations of human hippocampal subfield stiffness and memory performance. The Journal of Neuroscience 42(42), pp. 7957-7968. (10.1523/jneurosci.0592-22.2022)
- Hope, C., Hiscox, L. V., Halligan, S. L. and Creswell, C. 2022. Examining harmful impacts of the COVID‐19 pandemic and school closures on parents and carers in the United Kingdom: A rapid review. JCPP Advances 2(3), article number: e12095. (10.1002/jcv2.12095)
- Diamond, P. R., Airdrie, J. N., Hiller, R., Fraser, A., Hiscox, L. V., Hamilton-Giachritsis, C. and Halligan, S. L. 2022. Change in prevalence of post-traumatic stress disorder in the two years following trauma: a meta-analytic study. European Journal of Psychotraumatology 13(1), article number: 2066456. (10.1080/20008198.2022.2066456)
- Hiscox, L. V., McGarry, M. D. J. and Johnston, C. L. 2022. Evaluation of cerebral cortex viscoelastic property estimation with nonlinear inversion magnetic resonance elastography. Physics in Medicine & Biology 67, article number: 95002. (10.1088/1361-6560/ac5fde)
- Hiscox, L. V. et al. 2021. Sex differences in post-traumatic stress disorder in a high adversity cohort of South African adolescents: an examination of depressive symptoms, age, and trauma type as explanatory factors. European Journal of Psychotraumatology 12(1), article number: 1978669. (10.1080/20008198.2021.1978669)
- Delgorio, P. L. et al. 2021. Effect of aging on the viscoelastic properties of hippocampal subfields assessed with high-resolution MR elastography. Cerebral Cortex 31(6), pp. 2799-2811. (10.1093/cercor/bhaa388)
- Sanjana F, F. et al. 2021. Blood lipid markers are associated with hippocampal viscoelastic properties and memory in humans. Journal of Cerebral Blood Flow and Metabolism 41(6), pp. 1417-1427. (10.1177/0271678x20968032)
- Hiscox, L. V., Schwarb, H., McGarry, M. D. and Johnson, C. L. 2021. Aging brain mechanics: Progress and promise of magnetic resonance elastography. NeuroImage 232, article number: 117889. (10.1016/j.neuroimage.2021.117889)
- Giudice, J. S., Alshareef, A., Wu, T., Knutsen, A. K., Hiscox, L. V., Johnson, C. L. and Panzer, M. B. 2021. Calibration of a heterogeneous brain model using a subject-specific inverse finite element approach. Frontiers in Bioengineering and Biotechnology 9, article number: 664268. (10.3389/fbioe.2021.664268)
- Hiscox, L. V. et al. 2020. Standard-space atlas of the viscoelastic properties of the human brain. Human Brain Mapping 41(18), pp. 5282-5300. (10.1002/hbm.25192)
- Hiscox, L. V. et al. 2019. Mechanical property alterations across the cerebral cortex due to Alzheimer’s disease. Brain Communications 2(1), pp. 16. (10.1093/braincomms/fcz049)
- Rzechorzek, N. M. et al. 2019. Network analysis of canine brain morphometry links tumour risk to oestrogen deficiency and accelerated brain ageing. Scientific Reports 9, article number: 12506. (10.1038/s41598-019-48446-0)
- Hiscox, L. V., Johnson, C. L., McGarry, M. D. J., Schwarb, H., Van Beek, E. J. R., Roberts, N. and Starr, J. M. 2018. Hippocampal viscoelasticity and episodic memory performance in healthy older adults examined with magnetic resonance elastography. Brain Imaging and Behavior 14(1), pp. 175-185. (10.1007/s11682-018-9988-8)
- Hiscox, L. V. et al. 2018. High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults. Neurobiology of Aging 65, pp. 158-167. (10.1016/j.neurobiolaging.2018.01.010)
- Hiscox, L. V. et al. 2016. Magnetic resonance elastography (MRE) of the human brain: technique, findings and clinical applications. Physics in Medicine & Biology 61(24), pp. R401-R437. (10.1088/0031-9155/61/24/r401)
- Hiscox, L., Leonaviciute, E. and Humby, T. 2014. The effects of automatic spelling correction software on understanding and comprehension in compensated dyslexia: improved recall following dictation. Dyslexia 20(3), pp. 208-224. (10.1002/dys.1480)
- FeldmanHall, O., Mobbs, D., Evans, D., Hiscox, L., Navrady, L. and Dalgleish, T. 2012. What we say and what we do: the relationship between real and hypothetical moral choices. Cognition 123(3), pp. 434-441. (10.1016/j.cognition.2012.02.001)
Conferences
- Träuble, J., Hiscox, L. V., Johnson, C. L., Schönlieb, C., Kaminski Schierle, G. S. and Aviles-Rivero, A. I. 2024. Adaptive neighborhoods in contrastive regression learning for brain age prediction. Presented at: NeurIPS 2024 Workshop: Self-Supervised Learning - Theory and Practice, Vancouver, Canada, 09 - 15 December 2024.
Bywgraffiad
- PhD, Niwrowyddoniaeth, Prifysgol Caeredin, y DU. Ariannwyd gan Alzheimer Scotland (2014 - 2018).
- Baglor mewn Gwyddoniaeth, Seicoleg Gymhwysol (dosbarth 1af), Prifysgol Caerdydd, y DU (2008 - 2012).
Anrhydeddau a dyfarniadau
- Gwobr Gyrfa Gynnar Ymddiriedolaeth Wellcome. " Mecanobioleg clefyd Alzheimer cyn-glinigol" (2023 - 2028).
- Gwobr Gyrfa Gynnar Seren Rising gan SINAPSE - Scottish Imaging Network (2021).
Aelodaethau proffesiynol
- ISTAART Aelodaeth Proffesiynol (Cymdeithas Ryngwladol Alzheimer's Association i hyrwyddo ymchwil a thriniaeth Alzheimer).
- Aelod o Grŵp Arbenigol Wellcome ym Mhrifysgol Caerdydd.
- Adolygydd Gwyddonydd ar gyfer Pwyllgor Adolygu Banc Bio Prifysgol Caerdydd.
- Aelod o'r Gymdeithas Ryngwladol ar gyfer Cyseiniant Magnetig mewn Meddygaeth (ISMRM).
- Cynrychiolydd dan hyfforddiant Grŵp Astudio MRE ISMRM (2019 - 2020).
Safleoedd academaidd blaenorol
- Cydymaith Ymchwil Ôl-ddoethurol; Adran Seicoleg, Prifysgol Caerfaddon, Y Deyrnas Unedig (2020 - 2023).
- Cydymaith Ymchwil Ôl-ddoethurol; Peirianneg Biofeddygol, Prifysgol Delaware, Unol Daleithiau (2018 - 2020).
Ymrwymiadau siarad cyhoeddus
Sgyrsiau gwahoddedig
- Gweithdy Data Ymennydd Dehongliadwy (IBD) yn Sefydliad Technoleg Brenhinol KTH; Stockholm, Sweden (2023)
- Sesiwn addysgol ISMRM ar "Cnau a Bolltau Elastigedd MR yn yr Ymennydd" yn ystod y cwrs: "Offer Newydd i'r Niwroradiolegydd"; Llundain (2022).
- SINAPSE ASM (Cyfarfod Gwyddonol Blynyddol Rhwydwaith Delweddu'r Alban); Glasgow (2021).
- Cynhadledd Flynyddol Alzheimer Scotland; Ar-lein (2021).
- Cymdeithas Ryngwladol ar gyfer Cyseiniant Magnetig mewn Meddygaeth (ISMRM); Montreal, Canada (2019)
Pwyllgorau ac adolygu
adolygydd cyfnodolion
• Niwrowyddoniaeth Delweddu • NeuroImage • Neuroimage: Clinigol • Ffiniau mewn Biobeirianneg a Biotechnoleg • Journal of Neuroimaging • Mapio Ymennydd Dynol • Journal of the Mechanical Behavior of Biomedical Materials • ActaBiomaterialia • Adroddiadau Gwyddonol.
Golygydd Adolygiad
• Niwrowyddoniaeth Drosiadol • Ffiniau mewn Heneiddio Niwrowyddoniaeth
Meysydd goruchwyliaeth
- Delweddu Cyseiniant Magnetig
- Elastograffi
- Mecaneg Meinwe yr Ymennydd
- Clefyd Alzheimer
- Clefydau niwroddirywiol
Goruchwyliaeth gyfredol
Robert Davis
Myfyriwr ymchwil
Contact Details
HiscoxL@caerdydd.ac.uk
+44 29208 74000 ext 20054
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Ystafell 1.031, Heol Maendy, Caerdydd, CF24 4HQ
+44 29208 74000 ext 20054
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Ystafell 1.031, Heol Maendy, Caerdydd, CF24 4HQ
Themâu ymchwil
Arbenigeddau
- Elastograffi
- Clefyd niwroddirywiol
- Niwroddelweddu
- MRI
- Mecaneg meinwe