![Lucy Hiscox](https://profiles-cardiff.imgix.net/attachments/4448?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Lucy Hiscox
(she/her)
Wellcome Trust Fellow
- Available for postgraduate supervision
Overview
I am interested in using advanced neuroimaging techniques to improve our understanding of the mechanisms behind the development of neurodegenerative conditions such as Alzheimer's disease. Most of my research has involved the application of magnetic resonance elastography (MRE) to quantify the mechanical properties of the brain non-invasively and in vivo. MRE is highly sensitive to the health of tissue microstructure, where tissue softening of the hippocampus is often observed in Alzheimer's disease, and increased hippocampal viscosity associated with poorer performance in cognitive tasks. In addition, we are only just beginning to realise the impact tissue mechanics has on other biological and chemical systems, and may in fact play a causal role in the development of certain diseases.
Publication
2024
- Träuble, J., Hiscox, L. V., Johnson, C. L., Schönlieb, C., Kaminski Schierle, G. S. and Aviles-Rivero, A. I. 2024. Contrastive learning with adaptive neighborhoods for brain age prediction on 3D stiffness maps. Transactions on Machine Learning Research
- McIlvain, G., Magoon, E. M., Clements, R. G., Merritt, A., Hiscox, L. V., Schwarb, H. and Johnson, C. L. 2024. Acute effects of high-intensity exercise on brain mechanical properties and cognitive function. Brain Imaging and Behavior 18, pp. 863-874. (10.1007/s11682-024-00873-y)
- Träuble, J., Hiscox, L. V., Johnson, C. L., Schönlieb, C., Kaminski Schierle, G. S. and Aviles-Rivero, A. I. 2024. Adaptive neighborhoods in contrastive regression learning for brain age prediction. Presented at: NeurIPS 2024 Workshop: Self-Supervised Learning - Theory and Practice, Vancouver, Canada, 09 - 15 December 2024.
2023
- Sanjana, F., Delgorio, P. L., DeConne, T. M., Hiscox, L. V., Pohlig, R. T., Johnson, C. L. and Martens, C. R. 2023. Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan. Journal of Cerebral Blood Flow & Metabolism 43(11), pp. 1931-1941. (10.1177/0271678X231186571)
- Tinney, E. M. et al. 2023. Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging. Psychophysiology 60(9), article number: e14306. (10.1111/psyp.14306)
- Hiscox, L. V., Sharp, T. H., Olff, M., Seedat, S. and Halligan, S. L. 2023. Sex-based contributors to and consequences of post-traumatic stress disorder. Current Psychiatry Reports 25, pp. 233-245. (10.1007/s11920-023-01421-z)
- Hiscox, L. V., Bray, S., Fraser, A., Meiser-Stedman, R., Seedat, S. and Halligan, S. L. 2023. Sex differences in the severity and natural recovery of child PTSD symptoms: a longitudinal analysis of children exposed to acute trauma. Psychological Medicine 53(6), pp. 2682-2688. (10.1017/S0033291721004694)
- Hiscox, L. V. et al. 2023. Antenatal maternal intimate partner violence exposure is associated with sex-specific alterations in brain structure among young infants: Evidence from a South African birth cohort. Developmental Cognitive Neuroscience 60, article number: 101210. (10.1016/j.dcn.2023.101210)
- Delgorio, P. L. et al. 2023. Hippocampal subfield viscoelasticity in amnestic mild cognitive impairment evaluated with MR elastography. NeuroImage: Clinical 37, article number: 103327. (10.1016/j.nicl.2023.103327)
2022
- Delgorio, P. L. et al. 2022. Structure–function dissociations of human hippocampal subfield stiffness and memory performance. The Journal of Neuroscience 42(42), pp. 7957-7968. (10.1523/jneurosci.0592-22.2022)
- Hope, C., Hiscox, L. V., Halligan, S. L. and Creswell, C. 2022. Examining harmful impacts of the COVID‐19 pandemic and school closures on parents and carers in the United Kingdom: A rapid review. JCPP Advances 2(3), article number: e12095. (10.1002/jcv2.12095)
- Diamond, P. R., Airdrie, J. N., Hiller, R., Fraser, A., Hiscox, L. V., Hamilton-Giachritsis, C. and Halligan, S. L. 2022. Change in prevalence of post-traumatic stress disorder in the two years following trauma: a meta-analytic study. European Journal of Psychotraumatology 13(1), article number: 2066456. (10.1080/20008198.2022.2066456)
- Hiscox, L. V., McGarry, M. D. J. and Johnston, C. L. 2022. Evaluation of cerebral cortex viscoelastic property estimation with nonlinear inversion magnetic resonance elastography. Physics in Medicine & Biology 67, article number: 95002. (10.1088/1361-6560/ac5fde)
2021
- Hiscox, L. V. et al. 2021. Sex differences in post-traumatic stress disorder in a high adversity cohort of South African adolescents: an examination of depressive symptoms, age, and trauma type as explanatory factors. European Journal of Psychotraumatology 12(1), article number: 1978669. (10.1080/20008198.2021.1978669)
- Delgorio, P. L. et al. 2021. Effect of aging on the viscoelastic properties of hippocampal subfields assessed with high-resolution MR elastography. Cerebral Cortex 31(6), pp. 2799-2811. (10.1093/cercor/bhaa388)
- Sanjana F, F. et al. 2021. Blood lipid markers are associated with hippocampal viscoelastic properties and memory in humans. Journal of Cerebral Blood Flow and Metabolism 41(6), pp. 1417-1427. (10.1177/0271678x20968032)
- Hiscox, L. V., Schwarb, H., McGarry, M. D. and Johnson, C. L. 2021. Aging brain mechanics: Progress and promise of magnetic resonance elastography. NeuroImage 232, article number: 117889. (10.1016/j.neuroimage.2021.117889)
- Giudice, J. S., Alshareef, A., Wu, T., Knutsen, A. K., Hiscox, L. V., Johnson, C. L. and Panzer, M. B. 2021. Calibration of a heterogeneous brain model using a subject-specific inverse finite element approach. Frontiers in Bioengineering and Biotechnology 9, article number: 664268. (10.3389/fbioe.2021.664268)
2020
- Hiscox, L. V. et al. 2020. Standard-space atlas of the viscoelastic properties of the human brain. Human Brain Mapping 41(18), pp. 5282-5300. (10.1002/hbm.25192)
2019
- Hiscox, L. V. et al. 2019. Mechanical property alterations across the cerebral cortex due to Alzheimer’s disease. Brain Communications 2(1), pp. 16. (10.1093/braincomms/fcz049)
- Rzechorzek, N. M. et al. 2019. Network analysis of canine brain morphometry links tumour risk to oestrogen deficiency and accelerated brain ageing. Scientific Reports 9, article number: 12506. (10.1038/s41598-019-48446-0)
2018
- Hiscox, L. V., Johnson, C. L., McGarry, M. D. J., Schwarb, H., Van Beek, E. J. R., Roberts, N. and Starr, J. M. 2018. Hippocampal viscoelasticity and episodic memory performance in healthy older adults examined with magnetic resonance elastography. Brain Imaging and Behavior 14(1), pp. 175-185. (10.1007/s11682-018-9988-8)
- Hiscox, L. V. et al. 2018. High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults. Neurobiology of Aging 65, pp. 158-167. (10.1016/j.neurobiolaging.2018.01.010)
2016
- Hiscox, L. V. et al. 2016. Magnetic resonance elastography (MRE) of the human brain: technique, findings and clinical applications. Physics in Medicine & Biology 61(24), pp. R401-R437. (10.1088/0031-9155/61/24/r401)
2014
- Hiscox, L., Leonaviciute, E. and Humby, T. 2014. The effects of automatic spelling correction software on understanding and comprehension in compensated dyslexia: improved recall following dictation. Dyslexia 20(3), pp. 208-224. (10.1002/dys.1480)
2012
- FeldmanHall, O., Mobbs, D., Evans, D., Hiscox, L., Navrady, L. and Dalgleish, T. 2012. What we say and what we do: the relationship between real and hypothetical moral choices. Cognition 123(3), pp. 434-441. (10.1016/j.cognition.2012.02.001)
Articles
- Träuble, J., Hiscox, L. V., Johnson, C. L., Schönlieb, C., Kaminski Schierle, G. S. and Aviles-Rivero, A. I. 2024. Contrastive learning with adaptive neighborhoods for brain age prediction on 3D stiffness maps. Transactions on Machine Learning Research
- McIlvain, G., Magoon, E. M., Clements, R. G., Merritt, A., Hiscox, L. V., Schwarb, H. and Johnson, C. L. 2024. Acute effects of high-intensity exercise on brain mechanical properties and cognitive function. Brain Imaging and Behavior 18, pp. 863-874. (10.1007/s11682-024-00873-y)
- Sanjana, F., Delgorio, P. L., DeConne, T. M., Hiscox, L. V., Pohlig, R. T., Johnson, C. L. and Martens, C. R. 2023. Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan. Journal of Cerebral Blood Flow & Metabolism 43(11), pp. 1931-1941. (10.1177/0271678X231186571)
- Tinney, E. M. et al. 2023. Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging. Psychophysiology 60(9), article number: e14306. (10.1111/psyp.14306)
- Hiscox, L. V., Sharp, T. H., Olff, M., Seedat, S. and Halligan, S. L. 2023. Sex-based contributors to and consequences of post-traumatic stress disorder. Current Psychiatry Reports 25, pp. 233-245. (10.1007/s11920-023-01421-z)
- Hiscox, L. V., Bray, S., Fraser, A., Meiser-Stedman, R., Seedat, S. and Halligan, S. L. 2023. Sex differences in the severity and natural recovery of child PTSD symptoms: a longitudinal analysis of children exposed to acute trauma. Psychological Medicine 53(6), pp. 2682-2688. (10.1017/S0033291721004694)
- Hiscox, L. V. et al. 2023. Antenatal maternal intimate partner violence exposure is associated with sex-specific alterations in brain structure among young infants: Evidence from a South African birth cohort. Developmental Cognitive Neuroscience 60, article number: 101210. (10.1016/j.dcn.2023.101210)
- Delgorio, P. L. et al. 2023. Hippocampal subfield viscoelasticity in amnestic mild cognitive impairment evaluated with MR elastography. NeuroImage: Clinical 37, article number: 103327. (10.1016/j.nicl.2023.103327)
- Delgorio, P. L. et al. 2022. Structure–function dissociations of human hippocampal subfield stiffness and memory performance. The Journal of Neuroscience 42(42), pp. 7957-7968. (10.1523/jneurosci.0592-22.2022)
- Hope, C., Hiscox, L. V., Halligan, S. L. and Creswell, C. 2022. Examining harmful impacts of the COVID‐19 pandemic and school closures on parents and carers in the United Kingdom: A rapid review. JCPP Advances 2(3), article number: e12095. (10.1002/jcv2.12095)
- Diamond, P. R., Airdrie, J. N., Hiller, R., Fraser, A., Hiscox, L. V., Hamilton-Giachritsis, C. and Halligan, S. L. 2022. Change in prevalence of post-traumatic stress disorder in the two years following trauma: a meta-analytic study. European Journal of Psychotraumatology 13(1), article number: 2066456. (10.1080/20008198.2022.2066456)
- Hiscox, L. V., McGarry, M. D. J. and Johnston, C. L. 2022. Evaluation of cerebral cortex viscoelastic property estimation with nonlinear inversion magnetic resonance elastography. Physics in Medicine & Biology 67, article number: 95002. (10.1088/1361-6560/ac5fde)
- Hiscox, L. V. et al. 2021. Sex differences in post-traumatic stress disorder in a high adversity cohort of South African adolescents: an examination of depressive symptoms, age, and trauma type as explanatory factors. European Journal of Psychotraumatology 12(1), article number: 1978669. (10.1080/20008198.2021.1978669)
- Delgorio, P. L. et al. 2021. Effect of aging on the viscoelastic properties of hippocampal subfields assessed with high-resolution MR elastography. Cerebral Cortex 31(6), pp. 2799-2811. (10.1093/cercor/bhaa388)
- Sanjana F, F. et al. 2021. Blood lipid markers are associated with hippocampal viscoelastic properties and memory in humans. Journal of Cerebral Blood Flow and Metabolism 41(6), pp. 1417-1427. (10.1177/0271678x20968032)
- Hiscox, L. V., Schwarb, H., McGarry, M. D. and Johnson, C. L. 2021. Aging brain mechanics: Progress and promise of magnetic resonance elastography. NeuroImage 232, article number: 117889. (10.1016/j.neuroimage.2021.117889)
- Giudice, J. S., Alshareef, A., Wu, T., Knutsen, A. K., Hiscox, L. V., Johnson, C. L. and Panzer, M. B. 2021. Calibration of a heterogeneous brain model using a subject-specific inverse finite element approach. Frontiers in Bioengineering and Biotechnology 9, article number: 664268. (10.3389/fbioe.2021.664268)
- Hiscox, L. V. et al. 2020. Standard-space atlas of the viscoelastic properties of the human brain. Human Brain Mapping 41(18), pp. 5282-5300. (10.1002/hbm.25192)
- Hiscox, L. V. et al. 2019. Mechanical property alterations across the cerebral cortex due to Alzheimer’s disease. Brain Communications 2(1), pp. 16. (10.1093/braincomms/fcz049)
- Rzechorzek, N. M. et al. 2019. Network analysis of canine brain morphometry links tumour risk to oestrogen deficiency and accelerated brain ageing. Scientific Reports 9, article number: 12506. (10.1038/s41598-019-48446-0)
- Hiscox, L. V., Johnson, C. L., McGarry, M. D. J., Schwarb, H., Van Beek, E. J. R., Roberts, N. and Starr, J. M. 2018. Hippocampal viscoelasticity and episodic memory performance in healthy older adults examined with magnetic resonance elastography. Brain Imaging and Behavior 14(1), pp. 175-185. (10.1007/s11682-018-9988-8)
- Hiscox, L. V. et al. 2018. High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults. Neurobiology of Aging 65, pp. 158-167. (10.1016/j.neurobiolaging.2018.01.010)
- Hiscox, L. V. et al. 2016. Magnetic resonance elastography (MRE) of the human brain: technique, findings and clinical applications. Physics in Medicine & Biology 61(24), pp. R401-R437. (10.1088/0031-9155/61/24/r401)
- Hiscox, L., Leonaviciute, E. and Humby, T. 2014. The effects of automatic spelling correction software on understanding and comprehension in compensated dyslexia: improved recall following dictation. Dyslexia 20(3), pp. 208-224. (10.1002/dys.1480)
- FeldmanHall, O., Mobbs, D., Evans, D., Hiscox, L., Navrady, L. and Dalgleish, T. 2012. What we say and what we do: the relationship between real and hypothetical moral choices. Cognition 123(3), pp. 434-441. (10.1016/j.cognition.2012.02.001)
Conferences
- Träuble, J., Hiscox, L. V., Johnson, C. L., Schönlieb, C., Kaminski Schierle, G. S. and Aviles-Rivero, A. I. 2024. Adaptive neighborhoods in contrastive regression learning for brain age prediction. Presented at: NeurIPS 2024 Workshop: Self-Supervised Learning - Theory and Practice, Vancouver, Canada, 09 - 15 December 2024.
Biography
- PhD, Neuroscience, University of Edinburgh, UK. Funded by Alzheimer Scotland (2014 - 2018).
- Bachelor of Science, Applied Psychology (1st class), Cardiff University, UK (2008 - 2012).
Honours and awards
- Wellcome Trust Early Career Award. “The Mechanobiology of Preclinical Alzheimer’s Disease” (2023 - 2028).
- Rising Star Early Career Award from SINAPSE - Scottish Imaging Network (2021).
Professional memberships
- ISTAART Professional Membership (The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment).
- Member of the Wellcome Expert Group at Cardiff University.
- Scientist Reviewer for Cardiff University Biobank’s Review Committee.
- Member of the International Society for Magnetic Resonance in Medicine (ISMRM).
- Trainee Representative of the ISMRM MRE Study Group (2019 - 2020).
Academic positions
- Postdoctoral Research Associate; Department of Psychology, University of Bath, United Kingdom (2020 - 2023).
- Postdoctoral Research Associate; Biomedical Engineering, University of Delaware, United States (2018 - 2020).
Speaking engagements
Invited talks
- Interpretable Brain Data (IBD) workshop at KTH Royal Institute of Technology; Stockholm, Sweden (2023).
- ISMRM educational session on “The Nuts and Bolts of MR Elastography in the Brain” during the course: “New Tools for the Neuroradiologist”; London (2022).
- SINAPSE ASM (Scottish Imaging Network Annual Scientific Meeting); Glasgow (2021).
- Alzheimer Scotland Annual Conference; Online (2021).
- International Society for Magnetic Resonance in Medicine (ISMRM); Montreal, Canada (2019).
Committees and reviewing
Journal reviewer
• Imaging Neuroscience • NeuroImage • Neuroimage: Clinical • Frontiers in Bioengineering and Biotechnology • Journal of Neuroimaging • Human Brain Mapping • Journal of the Mechanical Behavior of Biomedical Materials • ActaBiomaterialia • Scientific Reports.
Review Editor
• Translational Neuroscience • Frontiers in Aging Neuroscience
Supervisions
- Magnetic Resonance Imaging
- Elastography
- Brain Tissue Mechanics
- Alzheimer's disease
- Neurodegenerative diseases
Current supervision
Robert Davis
Research student
Contact Details
HiscoxL@cardiff.ac.uk
+44 29208 74000 ext 20054
Cardiff University Brain Research Imaging Centre, Room 1.031, Maindy Road, Cardiff, CF24 4HQ
+44 29208 74000 ext 20054
Cardiff University Brain Research Imaging Centre, Room 1.031, Maindy Road, Cardiff, CF24 4HQ
Research themes
Specialisms
- Elastography
- Neurodegenerative disease
- Neuroimaging
- MRI
- Tissue Mechanics