Trosolwyg
Mae Dr Hoogendoorn yn Ddarlithydd yn y Ganolfan Addysg Feddygol yn yr Ysgol Feddygaeth. Dr Hoogendoorn yw'r 'Argyfwng, Cyn-ysbyty a Gofal Uniongyrchol' Intercalated BSc Dirprwy Gyfarwyddwr Rhaglen ac arweinydd modiwl ymchwil.
Cyhoeddiad
2016
- Clark, J., Gregory, C. J., Matthews, I. P. and Hoogendoorn, B. 2016. The biological effects upon the cardiovascular system consequent to exposure to particulates of less than 500 nm in size. Biomarkers 21(1), pp. 1-47. (10.3109/1354750X.2015.1118540)
2013
- Matthews, I. P., Gregory, C. J., Aljayyoussi, G., Morris, C. J., McDonald, I., Hoogendoorn, B. and Gumbleton, M. 2013. Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat. Environmental Toxicology and Pharmacology 35(3), pp. 461-464. (10.1016/j.etap.2013.02.002)
- Elvidge, T., Matthews, I. P., Gregory, C. and Hoogendoorn, B. 2013. Feasibility of using biomarkers in blood serum as markers of effect following exposure of the lungs to particulate matter air pollution [review]. Journal of Environmental Science and Health, Part C 31(1), pp. 1-44. (10.1080/10590501.2013.763575)
- Van Woerden, H. C., Gregory, C. J., Brown, R. C., Marchesi, J. R., Hoogendoorn, B. and Matthews, I. P. 2013. Differences in fungi present in induced sputum samples from asthma patients and non-atopic controls: a community based case control study. BMC Infectious Diseases 13, article number: 69. (10.1186/1471-2334-13-69)
2012
- Hoogendoorn, B. et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600)
- Deschepper, M. P., Hoogendoorn, B., Brooks, S. P., Dunnett, S. B. and Jones, L. 2012. Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes. Brain Research Bulletin 88(2-3), pp. 210-222. (10.1016/j.brainresbull.2011.01.012)
2010
- Price, H. D. et al. 2010. Airborne particles in Swansea, UK: their collection and characterization. Journal of Toxicology and Environmental Health-Part A 73(5-6), pp. 355-367. (10.1080/15287390903442652)
2005
- Buckland, P. R., Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K. and O'Donovan, M. C. 2005. Strong bias in the location of functional promoter polymorphisms. Human Mutation 26(3), pp. 214-223. (10.1002/humu.20207)
- Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K., Coleman, S. L. and O'Donovan, M. C. 2005. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. American Journal of Psychiatry 162(3), pp. 613-615. (10.1176/appi.ajp.162.3.613)
2004
- Buckland, P. R. et al. 2004. A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Acta Biochimica et Biophysica 1690(3), pp. 238-249.
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2004. Functional analysis of polymorphisms in the promoter regions of genes on 22q11. Human Mutation 24(1), pp. 35-42. (10.1002/humu.20061)
- Guy, C., Hoogendoorn, B., Smith, S. K., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2004. Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 14(1), pp. 45-51. (10.1097/00008571-200401000-00005)
2003
- Smith, S. K., Hoogendoorn, B., Guy, C., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2003. Lack of functional promoter polymorphisms in genes involved in glutamate neurotransmission. Psychiatric Genetics 13(4), pp. 193-199. (10.1097/00041444-200312000-00001)
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., Bowen, T., Buckland, P. R. and O'Donovan, M. C. 2003. Functional analysis of human promoter polymorphisms. Human Molecular Genetics 12(18), pp. 2249-2254. (10.1093/hmg/ddg246)
- Buckland, P. R., Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2003. A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity. Gene Expression 11(5), pp. 233-239. (10.3727/000000003783992225)
2002
- Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2002. Streamlined approach to functional analysis of promoter-region polymorphisms. Biotechniques 33(2), pp. 412-418.
- Norton, N. et al. 2002. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Human Genetics 110(5), pp. 471-478. (10.1007/s00439-002-0706-6)
- Anney, R. et al. 2002. Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia. Molecular psychiatry 7(5), pp. 493-502. (10.1038/sj.mp.4001003)
- Williams, N. M. et al. 2002. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Molecular Psychiatry 7(5), pp. 508-514. (10.1038/sj.mp.4001030)
- Coleman, S. L., Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2002. Experimental analysis of the annotation of promoters in the public database. Human Molecular Genetics 11(16), pp. 1817-1821. (10.1093/hmg/11.16.1817)
2001
- Abraham, R. et al. 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109(6), pp. 646-652. (10.1007/s00439-001-0614-1)
- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6(3), pp. 259-260. (10.1038/sj.mp.4000128)
2000
- Austin, J. et al. 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5(5), pp. 552-557. (10.1038/sj.mp.4000761)
- Jones, A. C., Sampson, J. R., Hoogendoorn, B., Cohen, D. and Cheadle, J. P. 2000. Application and evaluation of denaturing HPLC for molecular genetic analysis in tuberous sclerosis. Human Genetics 106(6), pp. 663-668. (10.1007/s004390000316)
- Austin, J. et al. 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5(2), pp. 208-212. (10.1038/sj.mp.4000693)
- Austin, J. et al. 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10(1), pp. 51-54. (10.1097/00041444-200010010-00009)
- Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107(5), pp. 488-493. (10.1007/s004390000397)
- Speight, G. et al. 2000. Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Molecular Psychiatry 5(3), pp. 327-331. (10.1038/sj.mp.4000717)
1999
- Jacobsen, N. J. et al. 1999. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Human Molecular Genetics 8(9), pp. 1631-1636. (10.1093/hmg/8.9.1631)
- Jones, A. C., Austin, J., Hansen, N., Hoogendoorn, B., Oefner, P. J., Cheadle, J. P. and O'Donovan, M. C. 1999. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis. Clinical Chemistry 45(8), pp. 1133-1140.
- Hoogendoorn, B., Owen, M. J., Oefner, P. J., Williams, N. M., Austin, J. and O'Donovan, M. C. 1999. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Human Genetics 104(1), pp. 89-93. (10.1007/s004390050915)
Erthyglau
- Clark, J., Gregory, C. J., Matthews, I. P. and Hoogendoorn, B. 2016. The biological effects upon the cardiovascular system consequent to exposure to particulates of less than 500 nm in size. Biomarkers 21(1), pp. 1-47. (10.3109/1354750X.2015.1118540)
- Matthews, I. P., Gregory, C. J., Aljayyoussi, G., Morris, C. J., McDonald, I., Hoogendoorn, B. and Gumbleton, M. 2013. Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat. Environmental Toxicology and Pharmacology 35(3), pp. 461-464. (10.1016/j.etap.2013.02.002)
- Elvidge, T., Matthews, I. P., Gregory, C. and Hoogendoorn, B. 2013. Feasibility of using biomarkers in blood serum as markers of effect following exposure of the lungs to particulate matter air pollution [review]. Journal of Environmental Science and Health, Part C 31(1), pp. 1-44. (10.1080/10590501.2013.763575)
- Van Woerden, H. C., Gregory, C. J., Brown, R. C., Marchesi, J. R., Hoogendoorn, B. and Matthews, I. P. 2013. Differences in fungi present in induced sputum samples from asthma patients and non-atopic controls: a community based case control study. BMC Infectious Diseases 13, article number: 69. (10.1186/1471-2334-13-69)
- Hoogendoorn, B. et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600)
- Deschepper, M. P., Hoogendoorn, B., Brooks, S. P., Dunnett, S. B. and Jones, L. 2012. Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes. Brain Research Bulletin 88(2-3), pp. 210-222. (10.1016/j.brainresbull.2011.01.012)
- Price, H. D. et al. 2010. Airborne particles in Swansea, UK: their collection and characterization. Journal of Toxicology and Environmental Health-Part A 73(5-6), pp. 355-367. (10.1080/15287390903442652)
- Buckland, P. R., Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K. and O'Donovan, M. C. 2005. Strong bias in the location of functional promoter polymorphisms. Human Mutation 26(3), pp. 214-223. (10.1002/humu.20207)
- Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K., Coleman, S. L. and O'Donovan, M. C. 2005. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. American Journal of Psychiatry 162(3), pp. 613-615. (10.1176/appi.ajp.162.3.613)
- Buckland, P. R. et al. 2004. A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Acta Biochimica et Biophysica 1690(3), pp. 238-249.
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2004. Functional analysis of polymorphisms in the promoter regions of genes on 22q11. Human Mutation 24(1), pp. 35-42. (10.1002/humu.20061)
- Guy, C., Hoogendoorn, B., Smith, S. K., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2004. Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 14(1), pp. 45-51. (10.1097/00008571-200401000-00005)
- Smith, S. K., Hoogendoorn, B., Guy, C., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2003. Lack of functional promoter polymorphisms in genes involved in glutamate neurotransmission. Psychiatric Genetics 13(4), pp. 193-199. (10.1097/00041444-200312000-00001)
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., Bowen, T., Buckland, P. R. and O'Donovan, M. C. 2003. Functional analysis of human promoter polymorphisms. Human Molecular Genetics 12(18), pp. 2249-2254. (10.1093/hmg/ddg246)
- Buckland, P. R., Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2003. A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity. Gene Expression 11(5), pp. 233-239. (10.3727/000000003783992225)
- Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2002. Streamlined approach to functional analysis of promoter-region polymorphisms. Biotechniques 33(2), pp. 412-418.
- Norton, N. et al. 2002. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Human Genetics 110(5), pp. 471-478. (10.1007/s00439-002-0706-6)
- Anney, R. et al. 2002. Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia. Molecular psychiatry 7(5), pp. 493-502. (10.1038/sj.mp.4001003)
- Williams, N. M. et al. 2002. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Molecular Psychiatry 7(5), pp. 508-514. (10.1038/sj.mp.4001030)
- Coleman, S. L., Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2002. Experimental analysis of the annotation of promoters in the public database. Human Molecular Genetics 11(16), pp. 1817-1821. (10.1093/hmg/11.16.1817)
- Abraham, R. et al. 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109(6), pp. 646-652. (10.1007/s00439-001-0614-1)
- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6(3), pp. 259-260. (10.1038/sj.mp.4000128)
- Austin, J. et al. 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5(5), pp. 552-557. (10.1038/sj.mp.4000761)
- Jones, A. C., Sampson, J. R., Hoogendoorn, B., Cohen, D. and Cheadle, J. P. 2000. Application and evaluation of denaturing HPLC for molecular genetic analysis in tuberous sclerosis. Human Genetics 106(6), pp. 663-668. (10.1007/s004390000316)
- Austin, J. et al. 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5(2), pp. 208-212. (10.1038/sj.mp.4000693)
- Austin, J. et al. 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10(1), pp. 51-54. (10.1097/00041444-200010010-00009)
- Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107(5), pp. 488-493. (10.1007/s004390000397)
- Speight, G. et al. 2000. Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Molecular Psychiatry 5(3), pp. 327-331. (10.1038/sj.mp.4000717)
- Jacobsen, N. J. et al. 1999. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Human Molecular Genetics 8(9), pp. 1631-1636. (10.1093/hmg/8.9.1631)
- Jones, A. C., Austin, J., Hansen, N., Hoogendoorn, B., Oefner, P. J., Cheadle, J. P. and O'Donovan, M. C. 1999. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis. Clinical Chemistry 45(8), pp. 1133-1140.
- Hoogendoorn, B., Owen, M. J., Oefner, P. J., Williams, N. M., Austin, J. and O'Donovan, M. C. 1999. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Human Genetics 104(1), pp. 89-93. (10.1007/s004390050915)
Ymchwil
Bywgraffiad
Addysg a chymwysterau
1998: PhD (Bioleg Moleciwlaidd) BBSRC/Prifysgol Hertfortshire, UK.
1994: BSc ac MSc (Patholeg Planhigion/Nematoleg) Prifysgol Amaethyddol Wageningen, Wageningen, Yr Iseldiroedd.
1984: BSc (Sŵoleg a Microbioleg / Patholeg Planhigion) Prifysgol Natal, Pietermaritzburg, De Affrica.
Anrhydeddau a dyfarniadau
Sefydliad Bill a Melinda Gates $ 100,000. Datblygu offeryn pwynt gofal ar gyfer diagnosis cyflym o niwmonia. Rhwng mis Tachwedd 2015 a mis Mai 2017. Bastiaan Hoogendoorn, Colin Powell, Clive Gregory (Ysgol Meddygaeth), Jenna Bowen, Chris Allender (Ysgol Fferylliaeth).
Efrydiaeth PhD 2015, "Prosiect i bennu dichonoldeb mesur llwyth bacteriol mewn anadl allwthiol o blant â niwmonia ac empyema gan ddefnyddio prawf pwynt gofal newydd." Yn dechrau 5 Hydref 2015. CU Ysgol Meddygaeth / Sefydliad Gofal Sylfaenol ac Iechyd y Cyhoedd PhD Studenthip. Goruchwyliwr: Bastiaan Hoogendoorn; Cyd-oruchwylwyr: Colin Powell, Clive Gregory, Chris Allender.
Sefydliad Bill a Melinda Gates $ 100,000. Datblygu dyfais patsh micro-nodwydd hunan-weinyddol ar gyfer samplu cyfaint bach o waed ar draws y boblogaeth. O 1 Mai 2012 am 24 mis. Yr Athro I Matthews, Dr J Gallacher, Dr C Gregory, Dr B Hoogendoorn (Ysgol Meddygaeth) Yr Athro D Barrow (Ysgol Peirianneg) a Dr C Allender (Ysgol Fferylliaeth).
MRC/NERC project. £143,065. Astudiaeth archwiliadol sy'n ymchwilio i nodweddion ffisigo-gemegol sylfaenol gronynnau aer amgylchynol anadladwy sy'n gyfrifol am ddadreoleiddio genynnau ysgyfeiniol a phroteinau cysylltiedig. O fis Gorffennaf 2007 am flwyddyn. Yr Athro I Matthews, Dr B Hoogendoorm, Dr J Gregory, Dr K Berube, Dr T Jones.
Prosiect Ymchwil Cymdeithas Alzheimer. £131,314. Parhad dadansoddiad proteome cymharol o'r model llygoden clefyd Alzheimer trawsgenig Tg2576. O fis Hydref 2005 am 2 flynedd. B Hoogendoorn, PI; AL Jones, MJ Owen, MC O'Donovan, Cyd-PI.
Efrydiaeth PhD o UWCM a ddyfarnwyd i Ms Mia Deschepper (B Hoogendoorn ac AL Jones). Dadansoddiad proteomic o fodelau llygoden o glefyd Huntington. O fis Hydref 2003 am 3 blynedd.
Cymrodoriaeth Ymchwil Cymdeithas Alzheimer. £173,314. Dadansoddiad proteome cymharol o'r model llygoden clefyd Alzheimer trawsgenig Tg2576. O fis Hydref 2002 am 3 blynedd.
Aelodaethau proffesiynol
Cymrawd yr Academi Addysg Uwch