![Bastiaan Hoogendoorn BSc, MSc, PhD, FHEA](https://profiles-cardiff.imgix.net/attachments/7309?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Overview
Dr Hoogendoorn is a Lecturer in the Centre for Medical Education at the School of Medicine. Dr Hoogendoorn is the ‘Emergency, Pre-hospital and Immediate Care’ Intercalated BSc Deputy Programme Director and research module lead.
Publication
2016
- Clark, J., Gregory, C. J., Matthews, I. P. and Hoogendoorn, B. 2016. The biological effects upon the cardiovascular system consequent to exposure to particulates of less than 500 nm in size. Biomarkers 21(1), pp. 1-47. (10.3109/1354750X.2015.1118540)
2013
- Matthews, I. P., Gregory, C. J., Aljayyoussi, G., Morris, C. J., McDonald, I., Hoogendoorn, B. and Gumbleton, M. 2013. Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat. Environmental Toxicology and Pharmacology 35(3), pp. 461-464. (10.1016/j.etap.2013.02.002)
- Elvidge, T., Matthews, I. P., Gregory, C. and Hoogendoorn, B. 2013. Feasibility of using biomarkers in blood serum as markers of effect following exposure of the lungs to particulate matter air pollution [review]. Journal of Environmental Science and Health, Part C 31(1), pp. 1-44. (10.1080/10590501.2013.763575)
- Van Woerden, H. C., Gregory, C. J., Brown, R. C., Marchesi, J. R., Hoogendoorn, B. and Matthews, I. P. 2013. Differences in fungi present in induced sputum samples from asthma patients and non-atopic controls: a community based case control study. BMC Infectious Diseases 13, article number: 69. (10.1186/1471-2334-13-69)
2012
- Hoogendoorn, B. et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600)
- Deschepper, M. P., Hoogendoorn, B., Brooks, S. P., Dunnett, S. B. and Jones, L. 2012. Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes. Brain Research Bulletin 88(2-3), pp. 210-222. (10.1016/j.brainresbull.2011.01.012)
2010
- Price, H. D. et al. 2010. Airborne particles in Swansea, UK: their collection and characterization. Journal of Toxicology and Environmental Health-Part A 73(5-6), pp. 355-367. (10.1080/15287390903442652)
2005
- Buckland, P. R., Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K. and O'Donovan, M. C. 2005. Strong bias in the location of functional promoter polymorphisms. Human Mutation 26(3), pp. 214-223. (10.1002/humu.20207)
- Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K., Coleman, S. L. and O'Donovan, M. C. 2005. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. American Journal of Psychiatry 162(3), pp. 613-615. (10.1176/appi.ajp.162.3.613)
2004
- Buckland, P. R. et al. 2004. A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Acta Biochimica et Biophysica 1690(3), pp. 238-249.
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2004. Functional analysis of polymorphisms in the promoter regions of genes on 22q11. Human Mutation 24(1), pp. 35-42. (10.1002/humu.20061)
- Guy, C., Hoogendoorn, B., Smith, S. K., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2004. Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 14(1), pp. 45-51. (10.1097/00008571-200401000-00005)
2003
- Smith, S. K., Hoogendoorn, B., Guy, C., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2003. Lack of functional promoter polymorphisms in genes involved in glutamate neurotransmission. Psychiatric Genetics 13(4), pp. 193-199. (10.1097/00041444-200312000-00001)
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., Bowen, T., Buckland, P. R. and O'Donovan, M. C. 2003. Functional analysis of human promoter polymorphisms. Human Molecular Genetics 12(18), pp. 2249-2254. (10.1093/hmg/ddg246)
- Buckland, P. R., Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2003. A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity. Gene Expression 11(5), pp. 233-239. (10.3727/000000003783992225)
2002
- Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2002. Streamlined approach to functional analysis of promoter-region polymorphisms. Biotechniques 33(2), pp. 412-418.
- Norton, N. et al. 2002. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Human Genetics 110(5), pp. 471-478. (10.1007/s00439-002-0706-6)
- Anney, R. et al. 2002. Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia. Molecular psychiatry 7(5), pp. 493-502. (10.1038/sj.mp.4001003)
- Williams, N. M. et al. 2002. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Molecular Psychiatry 7(5), pp. 508-514. (10.1038/sj.mp.4001030)
- Coleman, S. L., Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2002. Experimental analysis of the annotation of promoters in the public database. Human Molecular Genetics 11(16), pp. 1817-1821. (10.1093/hmg/11.16.1817)
2001
- Abraham, R. et al. 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109(6), pp. 646-652. (10.1007/s00439-001-0614-1)
- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6(3), pp. 259-260. (10.1038/sj.mp.4000128)
2000
- Austin, J. et al. 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5(5), pp. 552-557. (10.1038/sj.mp.4000761)
- Jones, A. C., Sampson, J. R., Hoogendoorn, B., Cohen, D. and Cheadle, J. P. 2000. Application and evaluation of denaturing HPLC for molecular genetic analysis in tuberous sclerosis. Human Genetics 106(6), pp. 663-668. (10.1007/s004390000316)
- Austin, J. et al. 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5(2), pp. 208-212. (10.1038/sj.mp.4000693)
- Austin, J. et al. 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10(1), pp. 51-54. (10.1097/00041444-200010010-00009)
- Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107(5), pp. 488-493. (10.1007/s004390000397)
- Speight, G. et al. 2000. Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Molecular Psychiatry 5(3), pp. 327-331. (10.1038/sj.mp.4000717)
1999
- Jacobsen, N. J. et al. 1999. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Human Molecular Genetics 8(9), pp. 1631-1636. (10.1093/hmg/8.9.1631)
- Jones, A. C., Austin, J., Hansen, N., Hoogendoorn, B., Oefner, P. J., Cheadle, J. P. and O'Donovan, M. C. 1999. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis. Clinical Chemistry 45(8), pp. 1133-1140.
- Hoogendoorn, B., Owen, M. J., Oefner, P. J., Williams, N. M., Austin, J. and O'Donovan, M. C. 1999. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Human Genetics 104(1), pp. 89-93. (10.1007/s004390050915)
Articles
- Clark, J., Gregory, C. J., Matthews, I. P. and Hoogendoorn, B. 2016. The biological effects upon the cardiovascular system consequent to exposure to particulates of less than 500 nm in size. Biomarkers 21(1), pp. 1-47. (10.3109/1354750X.2015.1118540)
- Matthews, I. P., Gregory, C. J., Aljayyoussi, G., Morris, C. J., McDonald, I., Hoogendoorn, B. and Gumbleton, M. 2013. Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat. Environmental Toxicology and Pharmacology 35(3), pp. 461-464. (10.1016/j.etap.2013.02.002)
- Elvidge, T., Matthews, I. P., Gregory, C. and Hoogendoorn, B. 2013. Feasibility of using biomarkers in blood serum as markers of effect following exposure of the lungs to particulate matter air pollution [review]. Journal of Environmental Science and Health, Part C 31(1), pp. 1-44. (10.1080/10590501.2013.763575)
- Van Woerden, H. C., Gregory, C. J., Brown, R. C., Marchesi, J. R., Hoogendoorn, B. and Matthews, I. P. 2013. Differences in fungi present in induced sputum samples from asthma patients and non-atopic controls: a community based case control study. BMC Infectious Diseases 13, article number: 69. (10.1186/1471-2334-13-69)
- Hoogendoorn, B. et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600)
- Deschepper, M. P., Hoogendoorn, B., Brooks, S. P., Dunnett, S. B. and Jones, L. 2012. Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes. Brain Research Bulletin 88(2-3), pp. 210-222. (10.1016/j.brainresbull.2011.01.012)
- Price, H. D. et al. 2010. Airborne particles in Swansea, UK: their collection and characterization. Journal of Toxicology and Environmental Health-Part A 73(5-6), pp. 355-367. (10.1080/15287390903442652)
- Buckland, P. R., Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K. and O'Donovan, M. C. 2005. Strong bias in the location of functional promoter polymorphisms. Human Mutation 26(3), pp. 214-223. (10.1002/humu.20207)
- Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K., Coleman, S. L. and O'Donovan, M. C. 2005. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. American Journal of Psychiatry 162(3), pp. 613-615. (10.1176/appi.ajp.162.3.613)
- Buckland, P. R. et al. 2004. A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Acta Biochimica et Biophysica 1690(3), pp. 238-249.
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2004. Functional analysis of polymorphisms in the promoter regions of genes on 22q11. Human Mutation 24(1), pp. 35-42. (10.1002/humu.20061)
- Guy, C., Hoogendoorn, B., Smith, S. K., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2004. Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 14(1), pp. 45-51. (10.1097/00008571-200401000-00005)
- Smith, S. K., Hoogendoorn, B., Guy, C., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2003. Lack of functional promoter polymorphisms in genes involved in glutamate neurotransmission. Psychiatric Genetics 13(4), pp. 193-199. (10.1097/00041444-200312000-00001)
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., Bowen, T., Buckland, P. R. and O'Donovan, M. C. 2003. Functional analysis of human promoter polymorphisms. Human Molecular Genetics 12(18), pp. 2249-2254. (10.1093/hmg/ddg246)
- Buckland, P. R., Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2003. A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity. Gene Expression 11(5), pp. 233-239. (10.3727/000000003783992225)
- Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2002. Streamlined approach to functional analysis of promoter-region polymorphisms. Biotechniques 33(2), pp. 412-418.
- Norton, N. et al. 2002. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Human Genetics 110(5), pp. 471-478. (10.1007/s00439-002-0706-6)
- Anney, R. et al. 2002. Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia. Molecular psychiatry 7(5), pp. 493-502. (10.1038/sj.mp.4001003)
- Williams, N. M. et al. 2002. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Molecular Psychiatry 7(5), pp. 508-514. (10.1038/sj.mp.4001030)
- Coleman, S. L., Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2002. Experimental analysis of the annotation of promoters in the public database. Human Molecular Genetics 11(16), pp. 1817-1821. (10.1093/hmg/11.16.1817)
- Abraham, R. et al. 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109(6), pp. 646-652. (10.1007/s00439-001-0614-1)
- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6(3), pp. 259-260. (10.1038/sj.mp.4000128)
- Austin, J. et al. 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5(5), pp. 552-557. (10.1038/sj.mp.4000761)
- Jones, A. C., Sampson, J. R., Hoogendoorn, B., Cohen, D. and Cheadle, J. P. 2000. Application and evaluation of denaturing HPLC for molecular genetic analysis in tuberous sclerosis. Human Genetics 106(6), pp. 663-668. (10.1007/s004390000316)
- Austin, J. et al. 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5(2), pp. 208-212. (10.1038/sj.mp.4000693)
- Austin, J. et al. 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10(1), pp. 51-54. (10.1097/00041444-200010010-00009)
- Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107(5), pp. 488-493. (10.1007/s004390000397)
- Speight, G. et al. 2000. Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Molecular Psychiatry 5(3), pp. 327-331. (10.1038/sj.mp.4000717)
- Jacobsen, N. J. et al. 1999. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Human Molecular Genetics 8(9), pp. 1631-1636. (10.1093/hmg/8.9.1631)
- Jones, A. C., Austin, J., Hansen, N., Hoogendoorn, B., Oefner, P. J., Cheadle, J. P. and O'Donovan, M. C. 1999. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis. Clinical Chemistry 45(8), pp. 1133-1140.
- Hoogendoorn, B., Owen, M. J., Oefner, P. J., Williams, N. M., Austin, J. and O'Donovan, M. C. 1999. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Human Genetics 104(1), pp. 89-93. (10.1007/s004390050915)
Research
Biography
Education and qualifications
1998: PhD (Molecular Biology) BBSRC/University of Hertfortshire, UK.
1994: BSc & MSc(Plant Pathology/Nematology) Wageningen Agricultural University, Wageningen, The Netherlands.
1984: BSc (Zoology and Microbiology/Plant Pathology) University of Natal, Pietermaritzburg, South Africa.
Honours and awards
Bill and Melinda Gates Foundation. $100,000. The development of a point of care instrument for rapid diagnosis of pneumonia. From November 2015 to May 2017. Bastiaan Hoogendoorn, Colin Powell, Clive Gregory (School of Medicine), Jenna Bowen, Chris Allender (School of Pharmacy).
PhD Studentship 2015, "Project to determine the feasibility of measuring bacterial load in exhaled breath of children with pneumonia and empyema using a novel point-of-care test." Start 5 October 2015. CU School of Medicine/Institute of Primary Care and Public Health PhD Studentship. Supervisor: Bastiaan Hoogendoorn; Co-supervisors: Colin Powell, Clive Gregory, Chris Allender.
Bill and Melinda Gates Foundation. $100,000. The development of a cheap and simple to use self-administrable micro-needle patch device for population-wide of sampling of small volumes of blood. From 1 May 2012 for 24 months. Prof I Matthews, Dr J Gallacher, Dr C Gregory, Dr B Hoogendoorn (School of Medicine) Prof D Barrow (School of Engineering) & Dr C Allender (School of Pharmacy).
MRC/NERC project. £143,065. An exploratory study investigating the primary physico-chemical characteristics of respirable ambient air particulates which are responsible for the dysregulation of pulmonary genes and related proteins. From July 2007 for 1 year. Prof I Matthews, Dr B Hoogendoorm, Dr J Gregory, Dr K Berube, Dr T Jones.
Alzheimer's Society Research Project. £131,314. Continuation of Comparative proteome analysis of the transgenic Alzheimer's disease mouse model Tg2576. From October 2005 for 2 years. B Hoogendoorn, PI; AL Jones, MJ Owen, MC O'Donovan, Co-PI.
PhD studentship from UWCM awarded to Ms Mia Deschepper (B Hoogendoorn and AL Jones). Proteomic analysis of mouse models of Huntington's disease. From October 2003 for 3 years.
Alzheimer's Society Research Fellowship. £173,314. Comparative proteome analysis of the transgenic Alzheimer's disease mouse model Tg2576. From October 2002 for 3 years.
Professional memberships
Fellow of the Higher Education Academy