Dr Kathy Hughes

Cyhoeddiad

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Ymchwil

My main research interest is in the diagnosis and management of infections in primary care, particularly urinary tract infections (UTI). I am also interested in other common infections, antibiotic use and antimicrobial resistance, point of care tests & biomarkers and the diagnosis/identification of serious illness in children.

I have worked on two large prospective cohort studies concerning childhood UTI (the EURICA and DUTY studies) and the LUCI study which uses routinely collected electronic health records to look at outcomes following childhood UTI. I am also involved in several studies exploring the urinary microbiome (bacterial genomics) in children and adults with and without UTI.

Grants

Title: Wales Centre for Primary and Emergency (including Unscheduled) Care Research (PRIME) and Care Research Wales, Centre Extension. Applicants: Edwards A, Ahmed H, Brain K, Burton C, Carson-Stevens A, Chestnutt I, Davies F, Evans B, Francis N, Ford D, Gal M, Harris-Mayes R, Hiscock J, Hughes D, Hughes K, Jones J, Joseph-Williams N, Kenkre K, Khanom A, Kingston M, Law R, Lewis R, Llewellyn M, Nelson A, North R, Northway R, Phillips R, Pontin D, Poolman M, Porter A, Rees N, Rolph M, Smith S, Snooks H, Spasić I, Thomas-Jones E, Todd S, Wallace C, Watkins A, Wilkinson C, Williams M, Wood. Funder: Health and Care Research Wales. Amount: £4,634,746. Duration: April 2020-March 2025

Title: Quantitative mapping of the microbiome and resistome in urinary tract infection among women: a pump-priming interdisciplinary study Applicants: Gadalla A, Francis N, Connor T, Marchesi J, Hughes K, E Mahenthiralingam, Butler C. Funder: ISSF3 Population Award, Cardiff University/Wellcome. Amount: £43,322 . Duration: April 2019-July 2020

Title: Wales Centre for Primary and Emergency (including Unscheduled) Care Research (PRIME) and Care Research Wales, Centre Extension. Applicants: Edwards A, Brain K, Bulger J, Calder G, Carson-Stevens A, Chestnutt I, Davies F, van Deursen R, Evans B, Ford D, Francis N, Gal M, Gobat N, Harris-Mayes R, Hiscock J, Hood K, Hughes D, Hughes K, Joseph-Williams N, Kenkre J, Khanom A, Kingston M, Lewis R, North R, Phillips R, Porter A, Rees N, Rycroft-Malone J, Smith S, Smits S, Snooks H, Spasić I, Thomson C, Ud Din N, Wallace C, Watkins A, Wilkinson C, Williams M, Williams N, Wood F Amount: £1,799,934.62 Duration: 1/4/18 – 31/03/20

Title: The LUCI study: The Long-term follow-up of Urinary tract infection (UTI) in Children. Applicants: O’Brien K, Cannings-John R, Paranjothy S, Francis N, Hay A, Butler C, Hood K. Funder:Health and Care Research Wales, Health Research Award Amount: £248,122. Duration: Oct 2016-June 2019

Title: Helpmedoit: A web and text based intervention to facilitate social support to achieve and maintain health related behaviour change. Applicants: Simpson S, Morgan Trimmer S, O’Brien K, Murphy S, Kelly M, Moore L, John E, McConnachie A, Mcintosh E Dunder: NIHR PHR Award Amount: £414,000. Duration: Feb 2015-July 2017.

Title: Symptoms of uncomplicated UTI in women presenting to general practice: exploration of causation in culture negative urine: The 'Missing link' study. Applicants: Butler C, Eberl M, Francis N, Gal M, Gregory C, Hood K, Howe R, Marchesi J, O’Brien K, Topley N, Wooton M. Funder: Wales School of Primary Care Research. Amount: £22,699 Duration:April 2014-2015

Title: Development of Polymerase Chain Reaction (PCR)/DNA pyrosequencing methods for the laboratory identification and analysis of urinary tract infections. Applicants: O’Brien K, Gregory C, Marchesi J, Francis N, Butler C. Funder: WellcomeTrust/ ISSF SEEDCORN Award. Amount: £50,000 Duration: June 2012-15

Title: DUTY: The Diagnosis of Urinary Tract Infection in Young Children Study. Applicants: Hay A, Butler C, Little P, Hood K, MacGowan A, Sterne J, Hollingworth W, Howe R, Whiting P, O’Brien K, Dudley J, van der Voort J, Montgomery A, Benger J, Fletcher M. Funder: NIHR HTA Award Amount: £3,255,125. Duration: Jan 2010-Dec 2016

Title: Microbiology and Infection Translational Research Group (MITReG). Applicants: Baille L, Barnes R, Brazier J, Bugert J, Butler C, Chalmers R, Cohen D, Corden S, Davies A, Davies E, Denyer S, Dunstan F, Eberl M, Edwards A, Evans M, Guy E, Hall J, Hastings M, Hay A, Heginbothom M, Henry R, Howe R, Hughes D, Kotecha S, Leaper D, Lewis M, Lovering A, Lyons M, Lyons R, MacGowan A, Mack D, Mahenthiralingam E, Maillard J, Marchesi J, Mason B, McGuigan C, O’Brien K, Price D, Sewell A, Taylor P, Thomas D, Topley N, Walsh T, Weightman A, White L, Wilkinson G, Williams D, Wootton M Funder: NISCHR Amount: £342,867 Duraton: March 2010- March 2015

Title: The Epidemiology of Urinary Tract Infection (UTI) in Children with Acute Illness in Primary Care (EURICA study). Applicants: Butler C, O’Brien K, Edwards A, Hood K. Funder: joint WAG/MRC Health Partnership Award Amount: £139,897. Duration: April 2008-March 2012

Addysgu

My teaching areas include infections, primary care research and epidemiology and quantitative research methods.

I am currently involved in teaching on the following courses:

• MB BCh C21 through Evidence based Medicine Tutorial sessions, Year 2 Case-based facilitator, SSCs and ISCE clinical examinations.
• Intercalated BSc in Population Medicine: Co-lead Short term conditions module & Project Supervisor

Bywgraffiad

Qualifications:

• PhD School of Medicine, Cardiff University 2013 (Childhood UTI)
• Dip Epi Diploma in Epidemiology London School of Hygiene and Tropical Medicine 2009
• PCME Postgraduate Certificate of Medical Education 2006
• MRCGP (Merit) Membership of the Royal College of General Practitioners 2003
• DFFP Diploma of the Faculty of Family Planning 2003
• DCH Diploma in Child Health 2001
• MB BCh Medical Degree 1998 Cardiff University

Overview of Career

• August 2020: Senior Clinical Lecturer, Division of Population Medicine, School of Medicine, Cardiff University & GP at Fairwater Health Centre, Cardiff.
• April 2020 - August 2020: Clinical Lecturer, Division of Population Medicine, School of Medicine, Cardiff University & GP at Fairwater Health Centre, Cardiff.
• Sep 2016 – April 2020: Senior Clinical Research Fellow, PRIME Centre Wales, School of Medicine, Cardiff University & GP
• Sep 2015 – Sep 2016: Maternity leave
• May 2005 – Sep 2015: Clinical Lecturer, School of Medicine, Cardiff University & GP (Partner Blaen-y-cwm Surgery Jan 2010-Dec 2014)
• Oct 2003 – May 2005: Associate Academic General Practitioner (Academic Fellow), School of Medicine, Cardiff University & GP
• Aug 2003 - Oct 2003: Locum General Practitioner
• Feb 2000 - Aug 2003: General Practice Vocational Training Scheme (Royal Glamorgan Hospital)
• Aug 1999 - Feb 2000: SHO in Accident and Emergency, Royal Gwent Hospital
• Feb1999 – Aug 1999: HO in Medicine (respiratory) Princess of Wales Hospital
• Aug 1998 – Feb 1999: HO in General Surgery Royal Gwent Hospital

Anrhydeddau a dyfarniadau

Jan 2020: Certificate of appreciation for teaching. School of Medicine, Cardiff University.

Research paper awards

2016 RCGP Research Paper of the year Category 3: Children, Reproduction, genetics, infections

Hay AD, Sterne JA, Hood K, Little P, Delaney B, Hollingworth W, et al. Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Study. Annals of family medicine. 2016;14(4):325-36.

2015 RCGP Research Paper of the year Category 3: Children, Reproduction, genetics, infections

Butler CC, O'Brien K, Pickles T, Hood K, Wootton M, Howe R, Waldron CA, Thomas-Jones E, Hollingworth W, Little P, Van Der Voort J, Dudley J, Rumsby K, Downing H, Harman K, Hay AD; DUTY study team. Childhood urinary tract infection in primary care: a prospective observational study of prevalence, diagnosis, treatment, and recovery. Br J Gen Pract. 2015 Apr;65(633):e217-23

Aelodaethau proffesiynol

Royal College of General Practitioners (since 2003)

Pwyllgorau ac adolygu

• Health and Care Research Wales All Wales Prioritisation Panel member (Aug 2019-present)

Meysydd goruchwyliaeth

I am interested in supervising PhD students in the areas of:

• Primary care
• Infections
• Urinary tract infections
• Antimicrobial resistance
• Urinary microbiome
• Point of care diagnostic tests

Goruchwyliaeth gyfredol

Adam Williams

Myfyriwr ymchwil