![Ian Humphreys](https://profiles-cardiff.imgix.net/attachments/9202?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Ian Humphreys
(e/fe)
Timau a rolau for Ian Humphreys
Athro Pathogenesis Firaol a Chyd-Gyfarwyddwr Arweiniol Sefydliad Ymchwil Imiwnedd Systemau
Trosolwyg
Rwy'n Athro Pathogenesis Firaol yn yr Is-adran Heintiau ac Imiwnedd, yr Ysgol Feddygaeth. Mae fy labordy yn astudio rheoleiddio ymatebion imiwnedd yn ystod heintiau firaol. Rwyf hefyd yn Gyd-gyfarwyddwr Arweiniol Sefydliad Ymchwil Prifysgol Imiwnedd Systemau ac yn Arweinydd Heintiau a Pandemigau.
Cyhoeddiad
2026
- Marsden, M. et al. 2026. Cytomegalovirus-induced T cell responses accelerate Alzheimer’s disease progression in mice. Brain awag043. (10.1093/brain/awag043)
2025
- Jenkins, B. J. et al., 2025. Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function. Nature Communications 16 (1) 9484. (10.1038/s41467-025-65417-4)
2024
- Al-Talib, M. , Dimonte, S. and Humphreys, I. R. 2024. Mucosal T-cell responses to chronic viral infections: Implications for vaccine design. Cellular & Molecular Immunology 21 , pp.982-998. (10.1038/s41423-024-01140-2)
- Bliss, C. M. et al. 2024. A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications. Molecular Therapy - Methods and Clinical Development 32 (3) 101308. (10.1016/j.omtm.2024.101308)
- Bliss, C. M. et al. 2024. A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications. Molecular Therapy Advances 32 (3) 101308. (10.1016/j.omtm.2024.101308)
- Amratia, P. S. et al. 2024. Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection. mBio 15 (8) e03152-23. (10.1128/mbio.03152-23)
- Hulin-Curtis, S. et al., 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43 (6) 114259. (10.1016/j.celrep.2024.114259)
2023
- Whiteside, S. K. et al., 2023. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Science Immunology 8 (90) eabo5558. (10.1126/sciimmunol.abo5558)
- Clement, M. et al. 2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12 e79165. (10.7554/eLife.79165)
2022
- Jessop, Z. M. et al., 2022. A study protocol for a double-blind randomised placebo-controlled trial evaluating the efficacy of carrageenan nasal and throat spray for COVID-19 prophylaxis—ICE-COVID. Trials 23 (1) 782. (10.1186/s13063-022-06685-z)
- Clement, M. et al. 2022. IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. Nature Communications 13 (1) 5294. (10.1038/s41467-022-32587-4)
- Asderakis, A. et al. 2022. An analysis of serological response and infection outcomes following Oxford-AstraZeneca (AZD1222) and Pfizer-BioNTech (mRNA BNT162b2) SARS-CoV-2 vaccines in kidney and kidney pancreas transplants. Transplantation 106 (7), pp.1421-1429. (10.1097/tp.0000000000004105)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75 (1), pp.e82-e88. ciac170. (10.1093/cid/ciac170)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Ponsford, M. J. et al. 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75 (4), pp.255-262. (10.1136/jclinpath-2020-207157)
2021
- Ponsford, M. J. et al. 2021. Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults. Thorax 76 (12), pp.1246-1249. (10.1136/thoraxjnl-2021-216964)
- Dimonte, S. et al. 2021. Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses. Immunology 164 (2), pp.279-291. (10.1111/imm.13368)
- Ponsford, M. J. et al. 2021. A systematic review and meta-analysis of inpatient mortality associated with nosocomial and community COVID-19 exposes the vulnerability of immunosuppressed adults. Frontiers in Immunology 12 744696. (10.3389/fimmu.2021.744696)
- Ponsford, M. J. et al. 2021. COVID-19 and X-linked agammaglobulinemia (XLA) - insights from a monogenic antibody deficiency. Current Opinion in Allergy and Clinical Immunology (10.1097/ACI.0000000000000792)
- Humphreys, I. R. and Godkin, A. J. 2021. Reply to a scientific basis for anxiety about the emergence of resistant strains of Covid-19. QJM: An International Journal of Medicine 114 (7)(10.1093/qjmed/hcab056)
- Clement, M. et al. 2021. IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses. Biorxiv
- Wellington, D. et al., 2021. IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans. European Journal of Immunology 51 (3), pp.742-745. (10.1002/eji.202048706)
- Forbester, J. L. and Humphreys, I. R. 2021. Genetic influences on viral-induced cytokine responses in the lung. Mucosal Immunology 14 , pp.14-25. (10.1038/s41385-020-00355-6)
2020
- Lucchesi, D. et al., 2020. Impaired IL‐27 mediated control of CD4+ T cell function impacts on ectopic lymphoid structure formation in patients with Sjögren's Syndrome. Arthritis and Rheumatology 72 (9), pp.1559-1570. Volume72, Issue9 September 2020 Pages 1559-1570. (10.1002/art.41289)
- Godkin, A. and Humphreys, I. R. 2020. Elevated interleukin‐6, interleukin‐10 and neutrophil : lymphocyte ratio as identifiers of severe coronavirus disease 2019 [Editorial]. Immunology 160 (3), pp.221-222. (10.1111/imm.13225)
- O'Donnell, V. B. et al. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1 (1) zqaa002. (10.1093/function/zqaa002)
- De Trez, C. et al., 2020. A critical Blimp-1-dependent IL-10 regulatory pathway in T cells protects from a lethal pro-inflammatory cytokine storm during acute experimental Trypanosoma brucei Infection. Frontiers in Immunology 11 1085. (10.3389/fimmu.2020.01085)
- Forbester, J. L. et al. 2020. IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models. Journal of Virology 94 (9) e00121-20. (10.1128/JVI.00121-20)
2019
- Shelkovnikova, T. A. et al. 2019. Antiviral immune response as a trigger of FUS proteinopathy in amyotrophic lateral sclerosis. Cell Reports 29 (13), pp.4496-4508.e4. (10.1016/j.celrep.2019.11.094)
- Singhania, A. et al., 2019. Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nature Communications 10 2887. (10.1038/s41467-019-10601-6)
- Thompson, A. et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15 (6) e1007850. (10.1371/journal.ppat.1007850)
- Smith, S. E. et al., 2019. Interferon-induced Transmembrane Protein 1 restricts replication of virus that enter cells via the plasma membrane.. Journal of Virology 93 (6) e02003-18. (10.1128/JVI.02003-18)
- McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202 (3), pp.943-955. (10.4049/jimmunol.1701757)
- Clement, M. and Humphreys, I. R. 2019. Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection. Frontiers in Immunology 10 78. (10.3389/fimmu.2019.00078)
2018
- Gimeno Brias, S. et al. 2018. Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection. PLoS ONE 13 (5) e0197596. (10.1371/journal.pone.0197596)
- Humphreys, I. R. and Sebastian, S. 2018. Novel viral vectors in infectious diseases. Immunology 153 (1), pp.1-9. (10.1111/imm.12829)
2017
- Rai, T. S. et al., 2017. Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Research 45 (20), pp.11673-11683. (10.1093/nar/gkx771)
- Sowerby, J. M. et al., 2017. NBEAL2 is required for neutrophil and NK cell function and pathogen defense. Journal of Clinical Investigation 127 (9), pp.3521-3526. (10.1172/JCI91684)
- Stacey, M. A. et al., 2017. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation 127 (4), pp.1463-1474. (10.1172/JCI84889)
2016
- Clement, M. et al. 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12 (12) e1006050. (10.1371/journal.ppat.1006050)
- Perks, W. V. et al. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186 (11), pp.2813-2823. (10.1016/j.ajpath.2016.07.021)
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9), pp.2222-2232. (10.1002/eji.201646528)
- Patin, E. et al. 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197 (1), pp.208-221. (10.4049/jimmunol.1501204)
- Gimeno Brias, S. et al., 2016. The role of IL-22 in viral infections: paradigms and paradoxes. Frontiers in Immunology 7 00211. (10.3389/fimmu.2016.00211)
- Mohammed, R. N. et al. 2016. L-selectin is essential for delivery of activated CD8+ T cells to virus-infected organs for protective immunity. Cell Reports 14 (4), pp.760-771. (10.1016/j.celrep.2015.12.090)
2015
- Stack, G. et al. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11 (2) e1004641. (10.1371/journal.ppat.1004641)
2014
- Greenhill, C. J. et al., 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16 (4) 419. (10.1186/s13075-014-0419-y)
- Stacey, M. A. et al. 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15 (4), pp.471-483. (10.1016/j.chom.2014.03.003)
- Fielding, C. A. et al. 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40 (1), pp.40-50. (10.1016/j.immuni.2013.10.022)
- Segrott, J. et al. 2014. Fidelity of implementation of the Strengthening Families Programme 10-14 UK in Wales UK: a mixed-method process evaluation within a randomised controlled trial. Presented at: 7th European Public Health Conference Glasgow, Scotland, 19-22 November 2014.
2013
- Greenhill, C. J. et al. 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63 (3), pp.267. (10.1016/j.cyto.2013.06.105)
2012
- Greenhill, C. et al. 2012. The regulation of arthritic bone erosions by il-10 [Abstract]. Rhuematology 51 , pp.48-48. (10.1093/rheumatology/kes117)
- Greenhill, C. J. et al. 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137 , pp.43-44.
- Humphreys, I. R. et al. 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12), pp.3235-3242. (10.1002/eji.201242575)
- Pembroke, T. et al. 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42 (9), pp.2383-2394. (10.1002/eji.201142072)
- Stack, G. , Stacey, M. A. and Humphreys, I. R. 2012. Herpesvirus exploitation of host immune inhibitory pathways. Viruses 4 (12), pp.1182-1201. (10.3390/v4081182)
- Twohig, J. P. et al. 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26 (8), pp.3575-3586. (10.1096/fj.11-200618)
2011
- Stacey, M. A. et al. 2011. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. The Journal of Immunology 187 (6), pp.2944-2952. (10.4049/jimmunol.1101021)
- Greenhill, C. J. et al. 2011. The regulation of arthritic bone erosions by IL-10 [Abstract]. Immunology 135 (s1), pp.158-158. (10.1111/j.1365-2567.2011.03534.x)
2010
- Jones, M. et al., 2010. IL-10 restricts memory T cell inflation during cytomegalovirus infection. The Journal of Immunology 185 (6), pp.3583-3592. (10.4049/jimmunol.1001535)
- Humphreys, I. R. et al. 2010. Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8+ T cells. European Journal of Immunology 40 (10), pp.2762-2768. (10.1002/eji.200940256)
2007
- Humphreys, I. R. et al. 2007. OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T cells: a CD4 dependent mechanism. Journal of Immunology 179 , pp.2195-2202.
- Humphreys, I. R. et al. 2007. Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands. Journal of Experimental Medicine 204 (5), pp.1217-25. (10.1084/jem.20062424)
2005
- Cheung, T. C. et al., 2005. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Proceedings of the National Academy of Sciences 102 (47), pp.13218-13223. (10.1073/pnas.0506172102)
- Stewart, G. R. et al., 2005. The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Molecular Microbiology 55 (4), pp.1127-1137. (10.1111/j.1365-2958.2004.04450.x)
2004
- Hale, C. et al., 2004. Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines. Vaccine 22 (27-28), pp.3595-3602. (10.1016/j.vaccine.2004.03.039)
- Hussell, T. et al., 2004. Co-stimulation: novel methods for preventing viral-induced lung inflammation. Trends in Molecular Medicine 10 (8), pp.379-386. (10.1016/j.molmed.2004.06.006)
2003
- Humphreys, I. R. et al. 2003. A critical role for OX40 in T cell-mediated immunopathology during lung viral infection. Journal of Experimental Medicine 198 (8), pp.1237-42. (10.1084/jem.20030351)
- Humphreys, I. et al. 2003. OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia. Journal of Immunology 170 (12), pp.6125-6132. (10.4049/jimmunol.170.12.6125)
- Walzl, G. et al., 2003. Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner. Infection and Immunity 71 (6), pp.3384-3391. (10.1128/IAI.71.6.3384-3391.2003)
2002
- Dearman, R. et al., 2002. Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides. Journal of Applied Toxicology 22 (5), pp.317-325. (10.1002/jat.865)
2000
- Dearman, R. et al., 2000. Characterization in mice of the immunological properties of five allergenic acid anhydrides. Journal of Applied Toxicology 20 (3), pp.221-230. (10.1002/(SICI)1099-1263(200005/06)20:3<221::AID-JAT651>3.0.CO;2-#)
Cynadleddau
- Segrott, J. et al. 2014. Fidelity of implementation of the Strengthening Families Programme 10-14 UK in Wales UK: a mixed-method process evaluation within a randomised controlled trial. Presented at: 7th European Public Health Conference Glasgow, Scotland, 19-22 November 2014.
Erthyglau
- Marsden, M. et al. 2026. Cytomegalovirus-induced T cell responses accelerate Alzheimer’s disease progression in mice. Brain awag043. (10.1093/brain/awag043)
- Jenkins, B. J. et al., 2025. Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function. Nature Communications 16 (1) 9484. (10.1038/s41467-025-65417-4)
- Al-Talib, M. , Dimonte, S. and Humphreys, I. R. 2024. Mucosal T-cell responses to chronic viral infections: Implications for vaccine design. Cellular & Molecular Immunology 21 , pp.982-998. (10.1038/s41423-024-01140-2)
- Bliss, C. M. et al. 2024. A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications. Molecular Therapy - Methods and Clinical Development 32 (3) 101308. (10.1016/j.omtm.2024.101308)
- Bliss, C. M. et al. 2024. A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications. Molecular Therapy Advances 32 (3) 101308. (10.1016/j.omtm.2024.101308)
- Amratia, P. S. et al. 2024. Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection. mBio 15 (8) e03152-23. (10.1128/mbio.03152-23)
- Hulin-Curtis, S. et al., 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43 (6) 114259. (10.1016/j.celrep.2024.114259)
- Whiteside, S. K. et al., 2023. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Science Immunology 8 (90) eabo5558. (10.1126/sciimmunol.abo5558)
- Clement, M. et al. 2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12 e79165. (10.7554/eLife.79165)
- Jessop, Z. M. et al., 2022. A study protocol for a double-blind randomised placebo-controlled trial evaluating the efficacy of carrageenan nasal and throat spray for COVID-19 prophylaxis—ICE-COVID. Trials 23 (1) 782. (10.1186/s13063-022-06685-z)
- Clement, M. et al. 2022. IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. Nature Communications 13 (1) 5294. (10.1038/s41467-022-32587-4)
- Asderakis, A. et al. 2022. An analysis of serological response and infection outcomes following Oxford-AstraZeneca (AZD1222) and Pfizer-BioNTech (mRNA BNT162b2) SARS-CoV-2 vaccines in kidney and kidney pancreas transplants. Transplantation 106 (7), pp.1421-1429. (10.1097/tp.0000000000004105)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75 (1), pp.e82-e88. ciac170. (10.1093/cid/ciac170)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Ponsford, M. J. et al. 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75 (4), pp.255-262. (10.1136/jclinpath-2020-207157)
- Ponsford, M. J. et al. 2021. Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults. Thorax 76 (12), pp.1246-1249. (10.1136/thoraxjnl-2021-216964)
- Dimonte, S. et al. 2021. Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses. Immunology 164 (2), pp.279-291. (10.1111/imm.13368)
- Ponsford, M. J. et al. 2021. A systematic review and meta-analysis of inpatient mortality associated with nosocomial and community COVID-19 exposes the vulnerability of immunosuppressed adults. Frontiers in Immunology 12 744696. (10.3389/fimmu.2021.744696)
- Ponsford, M. J. et al. 2021. COVID-19 and X-linked agammaglobulinemia (XLA) - insights from a monogenic antibody deficiency. Current Opinion in Allergy and Clinical Immunology (10.1097/ACI.0000000000000792)
- Humphreys, I. R. and Godkin, A. J. 2021. Reply to a scientific basis for anxiety about the emergence of resistant strains of Covid-19. QJM: An International Journal of Medicine 114 (7)(10.1093/qjmed/hcab056)
- Clement, M. et al. 2021. IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses. Biorxiv
- Wellington, D. et al., 2021. IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans. European Journal of Immunology 51 (3), pp.742-745. (10.1002/eji.202048706)
- Forbester, J. L. and Humphreys, I. R. 2021. Genetic influences on viral-induced cytokine responses in the lung. Mucosal Immunology 14 , pp.14-25. (10.1038/s41385-020-00355-6)
- Lucchesi, D. et al., 2020. Impaired IL‐27 mediated control of CD4+ T cell function impacts on ectopic lymphoid structure formation in patients with Sjögren's Syndrome. Arthritis and Rheumatology 72 (9), pp.1559-1570. Volume72, Issue9 September 2020 Pages 1559-1570. (10.1002/art.41289)
- Godkin, A. and Humphreys, I. R. 2020. Elevated interleukin‐6, interleukin‐10 and neutrophil : lymphocyte ratio as identifiers of severe coronavirus disease 2019 [Editorial]. Immunology 160 (3), pp.221-222. (10.1111/imm.13225)
- O'Donnell, V. B. et al. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1 (1) zqaa002. (10.1093/function/zqaa002)
- De Trez, C. et al., 2020. A critical Blimp-1-dependent IL-10 regulatory pathway in T cells protects from a lethal pro-inflammatory cytokine storm during acute experimental Trypanosoma brucei Infection. Frontiers in Immunology 11 1085. (10.3389/fimmu.2020.01085)
- Forbester, J. L. et al. 2020. IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models. Journal of Virology 94 (9) e00121-20. (10.1128/JVI.00121-20)
- Shelkovnikova, T. A. et al. 2019. Antiviral immune response as a trigger of FUS proteinopathy in amyotrophic lateral sclerosis. Cell Reports 29 (13), pp.4496-4508.e4. (10.1016/j.celrep.2019.11.094)
- Singhania, A. et al., 2019. Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nature Communications 10 2887. (10.1038/s41467-019-10601-6)
- Thompson, A. et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15 (6) e1007850. (10.1371/journal.ppat.1007850)
- Smith, S. E. et al., 2019. Interferon-induced Transmembrane Protein 1 restricts replication of virus that enter cells via the plasma membrane.. Journal of Virology 93 (6) e02003-18. (10.1128/JVI.02003-18)
- McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202 (3), pp.943-955. (10.4049/jimmunol.1701757)
- Clement, M. and Humphreys, I. R. 2019. Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection. Frontiers in Immunology 10 78. (10.3389/fimmu.2019.00078)
- Gimeno Brias, S. et al. 2018. Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection. PLoS ONE 13 (5) e0197596. (10.1371/journal.pone.0197596)
- Humphreys, I. R. and Sebastian, S. 2018. Novel viral vectors in infectious diseases. Immunology 153 (1), pp.1-9. (10.1111/imm.12829)
- Rai, T. S. et al., 2017. Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Research 45 (20), pp.11673-11683. (10.1093/nar/gkx771)
- Sowerby, J. M. et al., 2017. NBEAL2 is required for neutrophil and NK cell function and pathogen defense. Journal of Clinical Investigation 127 (9), pp.3521-3526. (10.1172/JCI91684)
- Stacey, M. A. et al., 2017. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation 127 (4), pp.1463-1474. (10.1172/JCI84889)
- Clement, M. et al. 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12 (12) e1006050. (10.1371/journal.ppat.1006050)
- Perks, W. V. et al. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186 (11), pp.2813-2823. (10.1016/j.ajpath.2016.07.021)
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9), pp.2222-2232. (10.1002/eji.201646528)
- Patin, E. et al. 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197 (1), pp.208-221. (10.4049/jimmunol.1501204)
- Gimeno Brias, S. et al., 2016. The role of IL-22 in viral infections: paradigms and paradoxes. Frontiers in Immunology 7 00211. (10.3389/fimmu.2016.00211)
- Mohammed, R. N. et al. 2016. L-selectin is essential for delivery of activated CD8+ T cells to virus-infected organs for protective immunity. Cell Reports 14 (4), pp.760-771. (10.1016/j.celrep.2015.12.090)
- Stack, G. et al. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11 (2) e1004641. (10.1371/journal.ppat.1004641)
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Ymchwil
Prif amcan ein labordy yw diffinio'r mecanweithiau biolegol sy'n rheoleiddio ymatebion imiwnedd i firysau.
Gall yr ymateb imiwnedd sy'n cael ei achosi ar haint firws weithredu fel cleddyf dwbl. Mae'r ymateb hwn yn hanfodol ar gyfer amddiffyniad rhag haint, fel y nodir gan dueddiad unigolion imiwnedd fel derbynwyr trawsblaniad organau solet imiwnedd i firysau. Fodd bynnag, mae llid a achosir gan firws yn cyfrannu at glefydau sy'n gysylltiedig â heintiau firaol fel ffliw, SARS-CoV2 a'r cytomegalofirws dynol herpesfirws. Ar ben hynny, mae'n dod yn fwyfwy amlwg bod herpesfirysau yn ffactorau risg yn natblygiad dementia, ac mae llid a achosir gan firws yn chwarae rhan allweddol yn natblygiad clefydau sy'n gysylltiedig â haint.
Trwy ddeall sut mae ymatebion imiwnedd i firysau yn cael eu rheoleiddio, mae ein labordy yn datblygu strategaethau i drin yr ymatebion hyn i gyflawni'r nodau canlynol:
- helpu i amddiffyn unigolion sy'n agored i niwed rhag heintiau firaol
- cyfyngu ar lid a achosir gan firws mewn clefydau fel dementia a chlefydau firysol anadlol
- gwella imiwnogenigrwydd brechlynnau canser sy'n seiliedig ar firws
Addysgu
MSc mewn Imiwnoleg Arbrofol a Chlinigol Gymhwysol - Modiwl Cyd-Arweinydd Heintiau
SSC Tiwtor Blwyddyn 1 – Prosiectau Llenyddiaeth
SSC Blwyddyn 2 – Goruchwyliwr Lleoliad Labordy
SSC Blwyddyn 2 – Tiwtor Grŵp Bach (Firoleg ac Imiwnoleg)
ME3045 Imiwnoleg Uwch
Ffarmacoleg Feddygol - Darlithio Imiwnoleg a Goruchwylio Lleoliad
Goruchwyliwr Lleoliad PTY Biowyddorau
Mentora Academaidd
Bywgraffiad
Addysg a Chymwysterau:
- 2004: PhD mewn Biocemeg, Canolfan Microbioleg Moleciwlaidd a Heintiau, Coleg Imperial Llundain
- 2000: BSc mewn Gwyddorau Biolegol gyda Firoleg, Prifysgol Warwick
Trosolwg o Yrfa:
Prifysgol Caerdydd, y DU (2007-presennol):
- 2021-Presennol: Cyd-gyfarwyddwr Arweiniol, Sefydliad Ymchwil Prifysgol Imiwnedd Systemau
- 2018-Presennol: Athro Pathogenesis Firaol
- 2012-presennol: Uwch Gymrawd Ymchwil Ymddiriedolaeth Wellcome
- 2007-2012: Cymrawd Datblygu Gyrfa Ymchwil Wellcome Trust
Sefydliad La Jolla ar gyfer Alergedd ac Imiwnoleg, San Diego UDA:
- 2000-2004: Ymchwilydd Ôl-ddoethurol
Coleg Imperial Llundain, DU:
- 2004: Ymchwilydd Ôl-ddoethurol
- 2000-2004: Myfyriwr PhD
Anrhydeddau a dyfarniadau
Major Honours and Distinctions:
2017: Awarded a Renewal of a Wellcome Trust Senior Fellowship in Basic Biomedical Science
2016: Appointed Member of the British Society of Immunology Congress Committee
2014: Appointed Member of the Wellcome Trust Basic Science Interview Committee
2013: Appointed as Honorary Faculty at the Wellcome Trust Sanger Institute
2012: Wellcome Trust Senior Fellowship in Basic Biomedical Science
2007: Wellcome Trust Research Career Development Fellowship
2002: 3rd Prize, Promega National Young Immunologist of the Year
2002: Marshall Scholarship for outstanding Ph.D in biomedical research
Aelodaethau proffesiynol
British Society of Immunology (BSI)
International Cytokine Society (ICS)
Society of General Microbiology
Safleoedd academaidd blaenorol
La Jolla Institute for Allergy and Immunology, San Diego USA:
2004-2006: Postdoctoral Scientist working with Professors Carl Ware and Mick Croft investigating the role of TNF and TNF receptor family members in T cell responses to cytomegalovirus infection.
Imperial College London, UK:
2004: Postdoctoral scientist working with Professor Douglas Young studying the dissemination of mycobacteria in vivo.
Pwyllgorau ac adolygu
- 2024-Presennol, Panel Grant Cychwynnol Sefydliad Gwyddoniaeth Cenedlaethol y Swistir (SNSF)
- 2020: Grŵp Adolygu Arbenigol System Imiwnedd mewn Iechyd a Chlefydau, Ymddiriedolaeth Wellcome
- 2016-2020: Cymdeithas Imiwnoleg Prydain, Pwyllgor y Gyngres
- 2014-2019: Pwyllgor Cyfweld Gwyddoniaeth Sylfaenol Wellcome Trust
Ymgysylltu
I am a member of the Welsh Government International Intelligence group, providing insight into the COVID-19 pandemic. In response to the COVID-19 pandemic, I have been engaging with numerous companies regarding SARS-CoV-2 research projects.
I have 18 years' experience of undertaking public engagement. I run a series of activities in primary schools including microscopic analysis of immune cells, performing experiments and using Lego to teach people of all ages about complex immunological concepts in a simple manner. My laboratory also coordinates the immunology section of the highly successful Science in Health Live! event promoting biomedical research to A-Level students. Participating students experience the laboratory setting and learn about harnessing the immune system to treat diseases and the different cutting edge technologies utilised in the lab.
