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Professor Ian Humphreys
(he/him)
Teams and roles for Ian Humphreys
Professor of Viral Pathogenesis and Lead Co-Director of Systems Immunity Research Institute
Overview
I am a Professor of Viral Pathogenesis within the Division of Infection & Immunity, School of Medicine. My laboratory studies the regulation of immune responses during viral infections. I am also Lead Co-Director of the Systems Immunity University Research Institute and Lead for Infections and Pandemics.
Publication
2025
- Jenkins, B. J. et al., 2025. Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function. Nature Communications 16 (1) 9484. (10.1038/s41467-025-65417-4)
2024
- Al-Talib, M. , Dimonte, S. and Humphreys, I. R. 2024. Mucosal T-cell responses to chronic viral infections: Implications for vaccine design. Cellular & Molecular Immunology 21 , pp.982-998. (10.1038/s41423-024-01140-2)
- Bliss, C. M. et al. 2024. A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications. Molecular Therapy - Methods and Clinical Development 32 (3) 101308. (10.1016/j.omtm.2024.101308)
- Amratia, P. S. et al. 2024. Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection. mBio 15 (8) e03152-23. (10.1128/mbio.03152-23)
- Hulin-Curtis, S. et al., 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43 (6) 114259. (10.1016/j.celrep.2024.114259)
2023
- Whiteside, S. K. et al., 2023. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Science Immunology 8 (90) eabo5558. (10.1126/sciimmunol.abo5558)
- Clement, M. et al. 2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12 e79165. (10.7554/eLife.79165)
2022
- Jessop, Z. M. et al., 2022. A study protocol for a double-blind randomised placebo-controlled trial evaluating the efficacy of carrageenan nasal and throat spray for COVID-19 prophylaxis—ICE-COVID. Trials 23 (1) 782. (10.1186/s13063-022-06685-z)
- Clement, M. et al. 2022. IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. Nature Communications 13 (1) 5294. (10.1038/s41467-022-32587-4)
- Asderakis, A. et al. 2022. An analysis of serological response and infection outcomes following Oxford-AstraZeneca (AZD1222) and Pfizer-BioNTech (mRNA BNT162b2) SARS-CoV-2 vaccines in kidney and kidney pancreas transplants. Transplantation 106 (7), pp.1421-1429. (10.1097/tp.0000000000004105)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75 (1), pp.e82-e88. ciac170. (10.1093/cid/ciac170)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Ponsford, M. J. et al. 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75 (4), pp.255-262. (10.1136/jclinpath-2020-207157)
2021
- Ponsford, M. J. et al. 2021. Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults. Thorax 76 (12), pp.1246-1249. (10.1136/thoraxjnl-2021-216964)
- Dimonte, S. et al. 2021. Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses. Immunology 164 (2), pp.279-291. (10.1111/imm.13368)
- Ponsford, M. J. et al. 2021. A systematic review and meta-analysis of inpatient mortality associated with nosocomial and community COVID-19 exposes the vulnerability of immunosuppressed adults. Frontiers in Immunology 12 744696. (10.3389/fimmu.2021.744696)
- Ponsford, M. J. et al. 2021. COVID-19 and X-linked agammaglobulinemia (XLA) - insights from a monogenic antibody deficiency. Current Opinion in Allergy and Clinical Immunology (10.1097/ACI.0000000000000792)
- Humphreys, I. R. and Godkin, A. J. 2021. Reply to a scientific basis for anxiety about the emergence of resistant strains of Covid-19. QJM: An International Journal of Medicine 114 (7)(10.1093/qjmed/hcab056)
- Clement, M. et al. 2021. IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses. Biorxiv
- Wellington, D. et al., 2021. IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans. European Journal of Immunology 51 (3), pp.742-745. (10.1002/eji.202048706)
- Forbester, J. L. and Humphreys, I. R. 2021. Genetic influences on viral-induced cytokine responses in the lung. Mucosal Immunology 14 , pp.14-25. (10.1038/s41385-020-00355-6)
2020
- Lucchesi, D. et al., 2020. Impaired IL‐27 mediated control of CD4+ T cell function impacts on ectopic lymphoid structure formation in patients with Sjögren's Syndrome. Arthritis and Rheumatology 72 (9), pp.1559-1570. Volume72, Issue9 September 2020 Pages 1559-1570. (10.1002/art.41289)
- Godkin, A. and Humphreys, I. R. 2020. Elevated interleukin‐6, interleukin‐10 and neutrophil : lymphocyte ratio as identifiers of severe coronavirus disease 2019 [Editorial]. Immunology 160 (3), pp.221-222. (10.1111/imm.13225)
- O'Donnell, V. B. et al. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1 (1) zqaa002. (10.1093/function/zqaa002)
- De Trez, C. et al., 2020. A critical Blimp-1-dependent IL-10 regulatory pathway in T cells protects from a lethal pro-inflammatory cytokine storm during acute experimental Trypanosoma brucei Infection. Frontiers in Immunology 11 1085. (10.3389/fimmu.2020.01085)
- Forbester, J. L. et al. 2020. IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models. Journal of Virology 94 (9) e00121-20. (10.1128/JVI.00121-20)
2019
- Shelkovnikova, T. A. et al. 2019. Antiviral immune response as a trigger of FUS proteinopathy in amyotrophic lateral sclerosis. Cell Reports 29 (13), pp.4496-4508.e4. (10.1016/j.celrep.2019.11.094)
- Singhania, A. et al., 2019. Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nature Communications 10 2887. (10.1038/s41467-019-10601-6)
- Thompson, A. et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15 (6) e1007850. (10.1371/journal.ppat.1007850)
- Smith, S. E. et al., 2019. Interferon-induced Transmembrane Protein 1 restricts replication of virus that enter cells via the plasma membrane.. Journal of Virology 93 (6) e02003-18. (10.1128/JVI.02003-18)
- McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202 (3), pp.943-955. (10.4049/jimmunol.1701757)
- Clement, M. and Humphreys, I. R. 2019. Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection. Frontiers in Immunology 10 78. (10.3389/fimmu.2019.00078)
2018
- Gimeno Brias, S. et al. 2018. Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection. PLoS ONE 13 (5) e0197596. (10.1371/journal.pone.0197596)
- Humphreys, I. R. and Sebastian, S. 2018. Novel viral vectors in infectious diseases. Immunology 153 (1), pp.1-9. (10.1111/imm.12829)
2017
- Rai, T. S. et al., 2017. Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Research 45 (20), pp.11673-11683. (10.1093/nar/gkx771)
- Sowerby, J. M. et al., 2017. NBEAL2 is required for neutrophil and NK cell function and pathogen defense. Journal of Clinical Investigation 127 (9), pp.3521-3526. (10.1172/JCI91684)
- Stacey, M. A. et al., 2017. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation 127 (4), pp.1463-1474. (10.1172/JCI84889)
2016
- Clement, M. et al. 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12 (12) e1006050. (10.1371/journal.ppat.1006050)
- Perks, W. V. et al. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186 (11), pp.2813-2823. (10.1016/j.ajpath.2016.07.021)
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9), pp.2222-2232. (10.1002/eji.201646528)
- Patin, E. et al. 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197 (1), pp.208-221. (10.4049/jimmunol.1501204)
- Gimeno Brias, S. et al., 2016. The role of IL-22 in viral infections: paradigms and paradoxes. Frontiers in Immunology 7 00211. (10.3389/fimmu.2016.00211)
- Mohammed, R. N. et al. 2016. L-selectin is essential for delivery of activated CD8+ T cells to virus-infected organs for protective immunity. Cell Reports 14 (4), pp.760-771. (10.1016/j.celrep.2015.12.090)
2015
- Stack, G. et al. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11 (2) e1004641. (10.1371/journal.ppat.1004641)
2014
- Greenhill, C. J. et al., 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16 (4) 419. (10.1186/s13075-014-0419-y)
- Stacey, M. A. et al. 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15 (4), pp.471-483. (10.1016/j.chom.2014.03.003)
- Fielding, C. A. et al. 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40 (1), pp.40-50. (10.1016/j.immuni.2013.10.022)
- Segrott, J. et al. 2014. Fidelity of implementation of the Strengthening Families Programme 10-14 UK in Wales UK: a mixed-method process evaluation within a randomised controlled trial. Presented at: 7th European Public Health Conference Glasgow, Scotland, 19-22 November 2014.
2013
- Greenhill, C. J. et al. 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63 (3), pp.267. (10.1016/j.cyto.2013.06.105)
2012
- Greenhill, C. et al. 2012. The regulation of arthritic bone erosions by il-10 [Abstract]. Rhuematology 51 , pp.48-48. (10.1093/rheumatology/kes117)
- Greenhill, C. J. et al. 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137 , pp.43-44.
- Humphreys, I. R. et al. 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12), pp.3235-3242. (10.1002/eji.201242575)
- Pembroke, T. et al. 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42 (9), pp.2383-2394. (10.1002/eji.201142072)
- Stack, G. , Stacey, M. A. and Humphreys, I. R. 2012. Herpesvirus exploitation of host immune inhibitory pathways. Viruses 4 (12), pp.1182-1201. (10.3390/v4081182)
- Twohig, J. P. et al. 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26 (8), pp.3575-3586. (10.1096/fj.11-200618)
2011
- Stacey, M. A. et al. 2011. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. The Journal of Immunology 187 (6), pp.2944-2952. (10.4049/jimmunol.1101021)
- Greenhill, C. J. et al. 2011. The regulation of arthritic bone erosions by IL-10 [Abstract]. Immunology 135 (s1), pp.158-158. (10.1111/j.1365-2567.2011.03534.x)
2010
- Jones, M. et al., 2010. IL-10 restricts memory T cell inflation during cytomegalovirus infection. The Journal of Immunology 185 (6), pp.3583-3592. (10.4049/jimmunol.1001535)
- Humphreys, I. R. et al. 2010. Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8+ T cells. European Journal of Immunology 40 (10), pp.2762-2768. (10.1002/eji.200940256)
2007
- Humphreys, I. R. et al. 2007. OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T cells: a CD4 dependent mechanism. Journal of Immunology 179 , pp.2195-2202.
- Humphreys, I. R. et al. 2007. Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands. Journal of Experimental Medicine 204 (5), pp.1217-25. (10.1084/jem.20062424)
2005
- Cheung, T. C. et al., 2005. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Proceedings of the National Academy of Sciences 102 (47), pp.13218-13223. (10.1073/pnas.0506172102)
- Stewart, G. R. et al., 2005. The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Molecular Microbiology 55 (4), pp.1127-1137. (10.1111/j.1365-2958.2004.04450.x)
2004
- Hale, C. et al., 2004. Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines. Vaccine 22 (27-28), pp.3595-3602. (10.1016/j.vaccine.2004.03.039)
- Hussell, T. et al., 2004. Co-stimulation: novel methods for preventing viral-induced lung inflammation. Trends in Molecular Medicine 10 (8), pp.379-386. (10.1016/j.molmed.2004.06.006)
2003
- Humphreys, I. R. et al. 2003. A critical role for OX40 in T cell-mediated immunopathology during lung viral infection. Journal of Experimental Medicine 198 (8), pp.1237-42. (10.1084/jem.20030351)
- Humphreys, I. et al. 2003. OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia. Journal of Immunology 170 (12), pp.6125-6132. (10.4049/jimmunol.170.12.6125)
- Walzl, G. et al., 2003. Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner. Infection and Immunity 71 (6), pp.3384-3391. (10.1128/IAI.71.6.3384-3391.2003)
2002
- Dearman, R. et al., 2002. Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides. Journal of Applied Toxicology 22 (5), pp.317-325. (10.1002/jat.865)
2000
- Dearman, R. et al., 2000. Characterization in mice of the immunological properties of five allergenic acid anhydrides. Journal of Applied Toxicology 20 (3), pp.221-230. (10.1002/(SICI)1099-1263(200005/06)20:3<221::AID-JAT651>3.0.CO;2-#)
Articles
- Jenkins, B. J. et al., 2025. Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function. Nature Communications 16 (1) 9484. (10.1038/s41467-025-65417-4)
- Al-Talib, M. , Dimonte, S. and Humphreys, I. R. 2024. Mucosal T-cell responses to chronic viral infections: Implications for vaccine design. Cellular & Molecular Immunology 21 , pp.982-998. (10.1038/s41423-024-01140-2)
- Bliss, C. M. et al. 2024. A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications. Molecular Therapy - Methods and Clinical Development 32 (3) 101308. (10.1016/j.omtm.2024.101308)
- Amratia, P. S. et al. 2024. Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection. mBio 15 (8) e03152-23. (10.1128/mbio.03152-23)
- Hulin-Curtis, S. et al., 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43 (6) 114259. (10.1016/j.celrep.2024.114259)
- Whiteside, S. K. et al., 2023. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Science Immunology 8 (90) eabo5558. (10.1126/sciimmunol.abo5558)
- Clement, M. et al. 2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12 e79165. (10.7554/eLife.79165)
- Jessop, Z. M. et al., 2022. A study protocol for a double-blind randomised placebo-controlled trial evaluating the efficacy of carrageenan nasal and throat spray for COVID-19 prophylaxis—ICE-COVID. Trials 23 (1) 782. (10.1186/s13063-022-06685-z)
- Clement, M. et al. 2022. IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. Nature Communications 13 (1) 5294. (10.1038/s41467-022-32587-4)
- Asderakis, A. et al. 2022. An analysis of serological response and infection outcomes following Oxford-AstraZeneca (AZD1222) and Pfizer-BioNTech (mRNA BNT162b2) SARS-CoV-2 vaccines in kidney and kidney pancreas transplants. Transplantation 106 (7), pp.1421-1429. (10.1097/tp.0000000000004105)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75 (1), pp.e82-e88. ciac170. (10.1093/cid/ciac170)
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Ponsford, M. J. et al. 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75 (4), pp.255-262. (10.1136/jclinpath-2020-207157)
- Ponsford, M. J. et al. 2021. Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults. Thorax 76 (12), pp.1246-1249. (10.1136/thoraxjnl-2021-216964)
- Dimonte, S. et al. 2021. Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses. Immunology 164 (2), pp.279-291. (10.1111/imm.13368)
- Ponsford, M. J. et al. 2021. A systematic review and meta-analysis of inpatient mortality associated with nosocomial and community COVID-19 exposes the vulnerability of immunosuppressed adults. Frontiers in Immunology 12 744696. (10.3389/fimmu.2021.744696)
- Ponsford, M. J. et al. 2021. COVID-19 and X-linked agammaglobulinemia (XLA) - insights from a monogenic antibody deficiency. Current Opinion in Allergy and Clinical Immunology (10.1097/ACI.0000000000000792)
- Humphreys, I. R. and Godkin, A. J. 2021. Reply to a scientific basis for anxiety about the emergence of resistant strains of Covid-19. QJM: An International Journal of Medicine 114 (7)(10.1093/qjmed/hcab056)
- Clement, M. et al. 2021. IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses. Biorxiv
- Wellington, D. et al., 2021. IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans. European Journal of Immunology 51 (3), pp.742-745. (10.1002/eji.202048706)
- Forbester, J. L. and Humphreys, I. R. 2021. Genetic influences on viral-induced cytokine responses in the lung. Mucosal Immunology 14 , pp.14-25. (10.1038/s41385-020-00355-6)
- Lucchesi, D. et al., 2020. Impaired IL‐27 mediated control of CD4+ T cell function impacts on ectopic lymphoid structure formation in patients with Sjögren's Syndrome. Arthritis and Rheumatology 72 (9), pp.1559-1570. Volume72, Issue9 September 2020 Pages 1559-1570. (10.1002/art.41289)
- Godkin, A. and Humphreys, I. R. 2020. Elevated interleukin‐6, interleukin‐10 and neutrophil : lymphocyte ratio as identifiers of severe coronavirus disease 2019 [Editorial]. Immunology 160 (3), pp.221-222. (10.1111/imm.13225)
- O'Donnell, V. B. et al. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1 (1) zqaa002. (10.1093/function/zqaa002)
- De Trez, C. et al., 2020. A critical Blimp-1-dependent IL-10 regulatory pathway in T cells protects from a lethal pro-inflammatory cytokine storm during acute experimental Trypanosoma brucei Infection. Frontiers in Immunology 11 1085. (10.3389/fimmu.2020.01085)
- Forbester, J. L. et al. 2020. IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models. Journal of Virology 94 (9) e00121-20. (10.1128/JVI.00121-20)
- Shelkovnikova, T. A. et al. 2019. Antiviral immune response as a trigger of FUS proteinopathy in amyotrophic lateral sclerosis. Cell Reports 29 (13), pp.4496-4508.e4. (10.1016/j.celrep.2019.11.094)
- Singhania, A. et al., 2019. Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nature Communications 10 2887. (10.1038/s41467-019-10601-6)
- Thompson, A. et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15 (6) e1007850. (10.1371/journal.ppat.1007850)
- Smith, S. E. et al., 2019. Interferon-induced Transmembrane Protein 1 restricts replication of virus that enter cells via the plasma membrane.. Journal of Virology 93 (6) e02003-18. (10.1128/JVI.02003-18)
- McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202 (3), pp.943-955. (10.4049/jimmunol.1701757)
- Clement, M. and Humphreys, I. R. 2019. Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection. Frontiers in Immunology 10 78. (10.3389/fimmu.2019.00078)
- Gimeno Brias, S. et al. 2018. Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection. PLoS ONE 13 (5) e0197596. (10.1371/journal.pone.0197596)
- Humphreys, I. R. and Sebastian, S. 2018. Novel viral vectors in infectious diseases. Immunology 153 (1), pp.1-9. (10.1111/imm.12829)
- Rai, T. S. et al., 2017. Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Research 45 (20), pp.11673-11683. (10.1093/nar/gkx771)
- Sowerby, J. M. et al., 2017. NBEAL2 is required for neutrophil and NK cell function and pathogen defense. Journal of Clinical Investigation 127 (9), pp.3521-3526. (10.1172/JCI91684)
- Stacey, M. A. et al., 2017. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation 127 (4), pp.1463-1474. (10.1172/JCI84889)
- Clement, M. et al. 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12 (12) e1006050. (10.1371/journal.ppat.1006050)
- Perks, W. V. et al. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186 (11), pp.2813-2823. (10.1016/j.ajpath.2016.07.021)
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9), pp.2222-2232. (10.1002/eji.201646528)
- Patin, E. et al. 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197 (1), pp.208-221. (10.4049/jimmunol.1501204)
- Gimeno Brias, S. et al., 2016. The role of IL-22 in viral infections: paradigms and paradoxes. Frontiers in Immunology 7 00211. (10.3389/fimmu.2016.00211)
- Mohammed, R. N. et al. 2016. L-selectin is essential for delivery of activated CD8+ T cells to virus-infected organs for protective immunity. Cell Reports 14 (4), pp.760-771. (10.1016/j.celrep.2015.12.090)
- Stack, G. et al. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11 (2) e1004641. (10.1371/journal.ppat.1004641)
- Greenhill, C. J. et al., 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16 (4) 419. (10.1186/s13075-014-0419-y)
- Stacey, M. A. et al. 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15 (4), pp.471-483. (10.1016/j.chom.2014.03.003)
- Fielding, C. A. et al. 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40 (1), pp.40-50. (10.1016/j.immuni.2013.10.022)
- Greenhill, C. J. et al. 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63 (3), pp.267. (10.1016/j.cyto.2013.06.105)
- Greenhill, C. et al. 2012. The regulation of arthritic bone erosions by il-10 [Abstract]. Rhuematology 51 , pp.48-48. (10.1093/rheumatology/kes117)
- Greenhill, C. J. et al. 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137 , pp.43-44.
- Humphreys, I. R. et al. 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12), pp.3235-3242. (10.1002/eji.201242575)
- Pembroke, T. et al. 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42 (9), pp.2383-2394. (10.1002/eji.201142072)
- Stack, G. , Stacey, M. A. and Humphreys, I. R. 2012. Herpesvirus exploitation of host immune inhibitory pathways. Viruses 4 (12), pp.1182-1201. (10.3390/v4081182)
- Twohig, J. P. et al. 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26 (8), pp.3575-3586. (10.1096/fj.11-200618)
- Stacey, M. A. et al. 2011. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. The Journal of Immunology 187 (6), pp.2944-2952. (10.4049/jimmunol.1101021)
- Greenhill, C. J. et al. 2011. The regulation of arthritic bone erosions by IL-10 [Abstract]. Immunology 135 (s1), pp.158-158. (10.1111/j.1365-2567.2011.03534.x)
- Jones, M. et al., 2010. IL-10 restricts memory T cell inflation during cytomegalovirus infection. The Journal of Immunology 185 (6), pp.3583-3592. (10.4049/jimmunol.1001535)
- Humphreys, I. R. et al. 2010. Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8+ T cells. European Journal of Immunology 40 (10), pp.2762-2768. (10.1002/eji.200940256)
- Humphreys, I. R. et al. 2007. OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T cells: a CD4 dependent mechanism. Journal of Immunology 179 , pp.2195-2202.
- Humphreys, I. R. et al. 2007. Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands. Journal of Experimental Medicine 204 (5), pp.1217-25. (10.1084/jem.20062424)
- Cheung, T. C. et al., 2005. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Proceedings of the National Academy of Sciences 102 (47), pp.13218-13223. (10.1073/pnas.0506172102)
- Stewart, G. R. et al., 2005. The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Molecular Microbiology 55 (4), pp.1127-1137. (10.1111/j.1365-2958.2004.04450.x)
- Hale, C. et al., 2004. Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines. Vaccine 22 (27-28), pp.3595-3602. (10.1016/j.vaccine.2004.03.039)
- Hussell, T. et al., 2004. Co-stimulation: novel methods for preventing viral-induced lung inflammation. Trends in Molecular Medicine 10 (8), pp.379-386. (10.1016/j.molmed.2004.06.006)
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- Humphreys, I. et al. 2003. OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia. Journal of Immunology 170 (12), pp.6125-6132. (10.4049/jimmunol.170.12.6125)
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- Dearman, R. et al., 2002. Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides. Journal of Applied Toxicology 22 (5), pp.317-325. (10.1002/jat.865)
- Dearman, R. et al., 2000. Characterization in mice of the immunological properties of five allergenic acid anhydrides. Journal of Applied Toxicology 20 (3), pp.221-230. (10.1002/(SICI)1099-1263(200005/06)20:3<221::AID-JAT651>3.0.CO;2-#)
Conferences
- Segrott, J. et al. 2014. Fidelity of implementation of the Strengthening Families Programme 10-14 UK in Wales UK: a mixed-method process evaluation within a randomised controlled trial. Presented at: 7th European Public Health Conference Glasgow, Scotland, 19-22 November 2014.
Research
The primary objective of our laboratory is to define the biological mechanisms that regulate immune responses to viruses.
The immune response that is induced upon a virus infection can act as a double-edged sword. This response is critical for protection from infection, as highlighted by the susceptibility of immunocompromised individuals such as immune-suppressed solid organ transplant recipients to viruses. However, virus-induced inflammation contributes to diseases associated with viral infections such as influenza, SARS-CoV2 and the herpesvirus human cytomegalovirus. Furthermore, it is becoming increasingly apparent that herpesviruses are risk factors in the development of dementia, and virus-induced inflammation plays a key role in infection-associated disease development.
By understanding how immune responses to viruses are regulated, our laboratory develops strategies to manipulate these responses to achieve the following goals:
- help protect susceptible individuals from viral infections
- limit virus-induced inflammation in diseases such as dementia and respiratory viral diseases
- improve the immunogenicity of virus-based cancer vaccines
Teaching
MSc in Applied Experimental & Clinical Immunology - Co-Lead of Infection Module
SSC Year 1 Tutor – Literature Projects
SSC Year 2 – Laboratory Placement Supervisor
SSC Year 2 – Small Group Tutor (Virology & Immunology)
ME3045 Advanced Immunology
Medical Pharmacology - Immunology lecturing and Placement Supervision
Biosciences PTY Placement Supervisor
Academic Mentoring
Biography
Education and Qualifications:
- 2004: PhD in Biochemistry, Centre of Molecular Microbiology and Infection, Imperial College London
- 2000: BSc in Biological Sciences with Virology, University of Warwick
Career Overview:
Cardiff University, UK (2007-Present):
- 2021-Present: Lead Co-Director, Systems Immunity University Research Institute
- 2018-Present: Professor of Viral Pathogenesis
- 2012-Present: Wellcome Trust Senior Research Fellow
- 2007-2012: Wellcome Trust Research Career Development Fellow
La Jolla Institute for Allergy and Immunology, San Diego USA:
- 2000-2004: Postdoctoral Researcher
Imperial College London, UK:
- 2004: Postdoctoral Researcher
- 2000-2004: PhD Student
Honours and awards
Major Honours and Distinctions:
- 2017: Awarded a Renewal of a Wellcome Trust Senior Fellowship in Basic Biomedical Science
- 2016: Appointed Member of the British Society of Immunology Congress Committee
- 2014: Appointed Member of the Wellcome Trust Basic Science Interview Committee
- 2013: Appointed as Honorary Faculty at the Wellcome Trust Sanger Institute
- 2012: Wellcome Trust Senior Fellowship in Basic Biomedical Science
- 2007: Wellcome Trust Research Career Development Fellowship
Professional memberships
- British Society of Immunology (BSI)
- International Cytokine Society (ICS)
- Society of General Microbiology
Academic positions
La Jolla Institute for Allergy and Immunology, San Diego USA:
2004-2006: Postdoctoral Scientist working with Professors Carl Ware and Mick Croft investigating the role of TNF and TNF receptor family members in T cell responses to cytomegalovirus infection.
Imperial College London, UK:
2004: Postdoctoral scientist working with Professor Douglas Young studying the dissemination of mycobacteria in vivo.
Committees and reviewing
- 2024-Present, Swiss National Science Foundation (SNSF) Starter Grant Panel
- 2020: Immune System in Health and Disease Expert Review Group, Wellcome Trust
- 2016-2020: British Society for Immunology, Congress Committee
- 2014-2019: Wellcome Trust Basic Science Interview Committee
Engagement
I am a member of the Welsh Government International Intelligence group, providing insight into the COVID-19 pandemic. In response to the COVID-19 pandemic, I have been engaging with numerous companies regarding SARS-CoV-2 research projects.
I have 18 years' experience of undertaking public engagement. I run a series of activities in primary schools including microscopic analysis of immune cells, performing experiments and using Lego to teach people of all ages about complex immunological concepts in a simple manner. My laboratory also coordinates the immunology section of the highly successful Science in Health Live! event promoting biomedical research to A-Level students. Participating students experience the laboratory setting and learn about harnessing the immune system to treat diseases and the different cutting edge technologies utilised in the lab.
