Yr Athro Derek Lang
(e/fe)
PhD FBPhS SFHEA
Cadeirydd Personol
- Sylwebydd y cyfryngau
Trosolwyg
Diddordebau Ymchwil Pwysig:
Roedd sylfeini fy ymchwil wedi'u lleoli ym maes bioleg celloedd cyhyrau llyfn endothelaidd a fasgwlaidd. Fy niddordeb penodol oedd yn y mecanweithiau sy'n tanseilio camweithrediad endothelial/fasgwlaidd mewn gwahanol gyflyrau clefyd cardiofasgwlaidd. Wedi bod yn "ymarferol" ers blynyddoedd lawer, rwyf bellach yn dilyn llwybr Addysgu ac Ysgolheictod. Rwy'n falch iawn o fod wedi cael dyrchafiad i'r Athro drwy'r llwybr hwn yn 2020. Yn bwysig, mae fy ymchwil flaenorol a'm diddordeb parhaus yn y maes yn tanio fy addysgu dan arweiniad ymchwil.
Ar ôl dysgu ar y cwrs am fwy o flynyddoedd nag yr wyf yn poeni ei gofio, rwyf wedi bod yn Gyfarwyddwr y cwrs BSc Ffarmacoleg Feddygol yn yr Ysgol Meddygaeth ers dros 10 mlynedd. Dros y cyfnod hwnnw mae'r rhaglen wedi mynd o nerth i nerth. Rydym yn helpu i ddatblygu graddedigion medrus iawn sy'n mynd ymlaen i rolau llwyddiannus mewn gwahanol sectorau o Feddygaeth Mynediad i Raddedigion a Deintyddiaeth i'r Diwydiant Fferyllol a thu hwnt.
Rwy'n arwain grŵp bach o addysgwyr proffesiynol ymroddedig iawn. Mae ein dychweliadau uchel dro ar ôl tro yn y Survery Myfyrwyr Cenedlaethol yn cynyddu eu hymdrechion enfawr wrth rymuso partneriaid dysgu i fod y graddedigion gorau y gallant fod.
Rwy'n ceisio cynnal cysylltiadau agos â Chymdeithas Ffarmacolegol Prydain, yr wyf yn Gymro ohoni.
Cyhoeddiad
2021
- Davies, R. et al. 2021. The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis. Rheumatology 60(6), pp. 2852-2861., article number: keaa725. (10.1093/rheumatology/keaa725)
2016
- Williams, J., Wang, E. C. Y., Lang, D. and Williams, A. S. 2016. Characterisation of Death Receptor 3 dependent aortic changes during inflammatory arthritis. Pharmacology Research & Perspectives 4(4), article number: e0024. (10.1002/prp2.240)
2013
- Taylor, S. Y., Dixon, H. M., Yoganayagam, S., Price, N. and Lang, D. 2013. Folic acid modulates eNOS activity via effects on posttranslational modifications and protein–protein interactions. European Journal of Pharmacology 714(1-3), pp. 193-201. (10.1016/j.ejphar.2013.05.026)
- Dada, J., Pinder, A. G., Lang, D. and James, P. E. 2013. Oxygen mediates vascular smooth muscle relaxation in hypoxia. PLoS ONE 8(2), article number: e57162. (10.1371/journal.pone.0057162)
2012
- Reynolds, S. L. et al. 2012. Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9. British Journal of Pharmacology 167(3), pp. 505-514. (10.1111/j.1476-5381.2012.01988.x)
2011
- Bundhoo, S. et al. 2011. Direct vasoactive properties of thienopyridine-derived nitrosothiols. Journal of Cardiovascular Pharmacology 58(5), pp. 550-558. (10.1097/FJC.0b013e31822f578c)
2010
- Caddy, J. et al. 2010. Rosiglitazone induces the unfolded protein response, but has no significant effect on cell viability, in monocytic and vascular smooth muscle cells. Biochemical and Biophysical Research Communications 400(4), pp. 689-695. (10.1016/j.bbrc.2010.08.129)
- Matthews, I. P., Henderson, K. A., Gregory, C. J., Palmer, S. R. and Lang, D. 2010. Effects of emissions from different type of residential heating upon cyclic guanosine monophosphate (cGMP) in blood platelets of residents. Biomarkers 15(1), pp. 86-93. (10.3109/13547500903311894)
2009
- Lang, D. and James, P. E. 2009. Free nitric oxide in spent CAPD fluid: a leap of faith?. Peritoneal Dialysis International 29(5), pp. 505-507.
2008
- Caddy, J. et al. 2008. Rosiglitazone transiently disturbs calcium homeostasis in monocytic cells. Biochemical and Biophysical Research Communications 366(1), pp. 149-155. (10.1016/j.bbrc.2007.11.095)
2006
- Clarke, Z. L., Moat, S. J., Miller, A. L., Randall, M. D., Lewis, M. J. and Lang, D. 2006. Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia. European Journal of Pharmacology 551(1-3), pp. 92-97. (10.1016/j.ejphar.2006.08.085)
- Moat, S. J. et al. 2006. High- but not low-dose folic acid improves endothelial function in coronary artery disease. European Journal Of Clinical Investigation 36(12), pp. 850-859. (10.1111/j.1365-2362.2006.01739.x)
- Moat, S. J., Clarke, Z. L., Madhavan, A. K., Lewis, M. J. and Lang, D. 2006. Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis. European Journal of Pharmacology 530(3), pp. 250-258. (10.1016/j.ejphar.2005.11.047)
2004
- Van Den Berg, C. W., Taylor, K. E. and Lang, D. 2004. C-reactive protein-induced in vitro vasorelaxation is an artefact caused by the presence of sodium azide in commercial preparations. Arteriosclerosis Thrombosis and Vascular Biology 24(10), pp. e168-171. (10.1161/01.ATV.0000142807.92781.d9)
- James, P. E., Lang, D., Tufnell-Barret, T., Milsom, A. B. and Frenneaux, M. P. 2004. Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobin. Circulation Research 94(7), pp. 976-983. (10.1161/01.RES.0000122044.21787.01)
2001
- Doshi, S. N. et al. 2001. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arteriosclerosis Thrombosis and Vascular Biology 21(7), pp. 1196-1202. (10.1161/hq0701.092000)
1993
- Lang, D., Warden-Smith, J. and Lewis, M. J. 1993. Induction of a calcium-independent NO synthase by hypercholesterolaemia in the rabbit. British Journal of Pharmacology 108(2), pp. 290-292.
- Williams, J., Lang, D., Warden-Smith, J. and Lewis, M. J. 1993. Plasma L-arginine levels in a rabbit model of hypercholesterolaemia. Biochemical Pharmacology 46(11), pp. 2097-2099. (10.1016/0006-2952(93)90653-E)
1990
- Warden-Smith, J. and Lang, D. 1990. Release of endothelium-derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in endothelial cell cyclic GMP content, is inhibited by a phorbol ester. British Journal of Pharmacology 99(3), pp. 565-71.
Articles
- Davies, R. et al. 2021. The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis. Rheumatology 60(6), pp. 2852-2861., article number: keaa725. (10.1093/rheumatology/keaa725)
- Williams, J., Wang, E. C. Y., Lang, D. and Williams, A. S. 2016. Characterisation of Death Receptor 3 dependent aortic changes during inflammatory arthritis. Pharmacology Research & Perspectives 4(4), article number: e0024. (10.1002/prp2.240)
- Taylor, S. Y., Dixon, H. M., Yoganayagam, S., Price, N. and Lang, D. 2013. Folic acid modulates eNOS activity via effects on posttranslational modifications and protein–protein interactions. European Journal of Pharmacology 714(1-3), pp. 193-201. (10.1016/j.ejphar.2013.05.026)
- Dada, J., Pinder, A. G., Lang, D. and James, P. E. 2013. Oxygen mediates vascular smooth muscle relaxation in hypoxia. PLoS ONE 8(2), article number: e57162. (10.1371/journal.pone.0057162)
- Reynolds, S. L. et al. 2012. Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9. British Journal of Pharmacology 167(3), pp. 505-514. (10.1111/j.1476-5381.2012.01988.x)
- Bundhoo, S. et al. 2011. Direct vasoactive properties of thienopyridine-derived nitrosothiols. Journal of Cardiovascular Pharmacology 58(5), pp. 550-558. (10.1097/FJC.0b013e31822f578c)
- Caddy, J. et al. 2010. Rosiglitazone induces the unfolded protein response, but has no significant effect on cell viability, in monocytic and vascular smooth muscle cells. Biochemical and Biophysical Research Communications 400(4), pp. 689-695. (10.1016/j.bbrc.2010.08.129)
- Matthews, I. P., Henderson, K. A., Gregory, C. J., Palmer, S. R. and Lang, D. 2010. Effects of emissions from different type of residential heating upon cyclic guanosine monophosphate (cGMP) in blood platelets of residents. Biomarkers 15(1), pp. 86-93. (10.3109/13547500903311894)
- Lang, D. and James, P. E. 2009. Free nitric oxide in spent CAPD fluid: a leap of faith?. Peritoneal Dialysis International 29(5), pp. 505-507.
- Caddy, J. et al. 2008. Rosiglitazone transiently disturbs calcium homeostasis in monocytic cells. Biochemical and Biophysical Research Communications 366(1), pp. 149-155. (10.1016/j.bbrc.2007.11.095)
- Clarke, Z. L., Moat, S. J., Miller, A. L., Randall, M. D., Lewis, M. J. and Lang, D. 2006. Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia. European Journal of Pharmacology 551(1-3), pp. 92-97. (10.1016/j.ejphar.2006.08.085)
- Moat, S. J. et al. 2006. High- but not low-dose folic acid improves endothelial function in coronary artery disease. European Journal Of Clinical Investigation 36(12), pp. 850-859. (10.1111/j.1365-2362.2006.01739.x)
- Moat, S. J., Clarke, Z. L., Madhavan, A. K., Lewis, M. J. and Lang, D. 2006. Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis. European Journal of Pharmacology 530(3), pp. 250-258. (10.1016/j.ejphar.2005.11.047)
- Van Den Berg, C. W., Taylor, K. E. and Lang, D. 2004. C-reactive protein-induced in vitro vasorelaxation is an artefact caused by the presence of sodium azide in commercial preparations. Arteriosclerosis Thrombosis and Vascular Biology 24(10), pp. e168-171. (10.1161/01.ATV.0000142807.92781.d9)
- James, P. E., Lang, D., Tufnell-Barret, T., Milsom, A. B. and Frenneaux, M. P. 2004. Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobin. Circulation Research 94(7), pp. 976-983. (10.1161/01.RES.0000122044.21787.01)
- Doshi, S. N. et al. 2001. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arteriosclerosis Thrombosis and Vascular Biology 21(7), pp. 1196-1202. (10.1161/hq0701.092000)
- Lang, D., Warden-Smith, J. and Lewis, M. J. 1993. Induction of a calcium-independent NO synthase by hypercholesterolaemia in the rabbit. British Journal of Pharmacology 108(2), pp. 290-292.
- Williams, J., Lang, D., Warden-Smith, J. and Lewis, M. J. 1993. Plasma L-arginine levels in a rabbit model of hypercholesterolaemia. Biochemical Pharmacology 46(11), pp. 2097-2099. (10.1016/0006-2952(93)90653-E)
- Warden-Smith, J. and Lang, D. 1990. Release of endothelium-derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in endothelial cell cyclic GMP content, is inhibited by a phorbol ester. British Journal of Pharmacology 99(3), pp. 565-71.
Addysgu
Rwy'n addysgu amrywiaeth eang o bynciau ar draws pob blwyddyn o'r rhaglen BSc Ffarmacoleg Feddygol. Er enghraifft, Ffarmacoleg System Nerfol Awtonomig ym Mlwyddyn 1, Ffarmacoleg Clefydau Trofannol ym Mlwyddyn 2, Ffarmacoleg Clefyd Cardiofasgwlaidd yn y flwyddyn olaf a llawer mwy rhyngddynt.
Rwy'n Uwch Gymrawd yr Academi Addysg Uwch (AdvanceHE).