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Yr Athro Derek Lang
(e/fe)
PhD FBPhS SFHEA
- Sylwebydd y cyfryngau
Timau a rolau for Derek Lang
Trosolwyg
Diddordebau Ymchwil Mawr:
Roedd sylfeini fy ymchwil wedi'u seilio ym maes bioleg celloedd cyhyrau llyfn endothelial a fasgwlaidd. Fy niddordeb arbennig oedd y mecanweithiau sy'n sail i gamweithrediad endothelial/fasgwlaidd mewn gwahanol gyflwr clefyd cardiofasgwlaidd. Wedi bod yn weithredol "ymarferol" ers blynyddoedd lawer, rydw i bellach yn dilyn llwybr Addysgu ac Ysgoloriaeth. Rwy'n falch iawn o gael fy dyrchafu'n Athro ar hyd y llwybr hwn yn 2020. Yn bwysig, mae fy ymchwil flaenorol a'm diddordeb parhaus yn y maes yn tanio fy addysgu dan arweiniad ymchwil.
Ar ôl dysgu ar y cwrs am fwy o flynyddoedd nag yr wyf yn gofalu amdano, rwyf wedi bod yn Gyfarwyddwr y cwrs BSc Ffarmacoleg Feddygol yn yr Ysgol Feddygaeth ers dros 10 mlynedd. Dros y cyfnod hwnnw mae'r rhaglen wedi mynd o nerth i nerth. Rydym yn helpu i ddatblygu graddedigion medrus iawn sy'n mynd ymlaen i rolau llwyddiannus mewn gwahanol sectorau o Feddygaeth Mynediad i Raddedigion a Deintyddiaeth i'r Diwydiant Fferyllol a thu hwnt.
Rwy'n arwain grŵp bach o addysgwyr proffesiynol ymroddedig iawn. Mae ein henillion uchel dro ar ôl tro yn y National Student Survery yn relfect eu hymdrechion enfawr i rymuso ein partneriaid dysgu i fod y graddedigion gorau y gallant fod.
Rwy'n ceisio cadw cysylltiadau agos â Chymdeithas Ffarmacolegol Prydain, yr wyf yn Gymrawd ohoni.
Cyhoeddiad
2025
- Tettey, L. , Umla-Runge, K. and Lang, D. 2025. Mental health decline of prematurely retired professional rugby players requires improved psychological support: a qualitative study of lived experiences. GLOBAL PSYCHIATRY ARCHIVES 8 (1), pp.42-59. (10.52095/gpa.2025.7565.1102)
2021
- Davies, R. et al. 2021. The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis. Rheumatology 60 (6), pp.2852-2861. keaa725. (10.1093/rheumatology/keaa725)
2016
- Williams, J. et al. 2016. Characterisation of Death Receptor 3 dependent aortic changes during inflammatory arthritis. Pharmacology Research & Perspectives 4 (4) e0024. (10.1002/prp2.240)
2013
- Taylor, S. Y. et al. 2013. Folic acid modulates eNOS activity via effects on posttranslational modifications and protein–protein interactions. European Journal of Pharmacology 714 (1-3), pp.193-201. (10.1016/j.ejphar.2013.05.026)
- Dada, J. et al. 2013. Oxygen mediates vascular smooth muscle relaxation in hypoxia. PLoS ONE 8 (2) e57162. (10.1371/journal.pone.0057162)
2012
- Reynolds, S. L. et al. 2012. Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9. British Journal of Pharmacology 167 (3), pp.505-514. (10.1111/j.1476-5381.2012.01988.x)
2011
- Bundhoo, S. et al. 2011. Direct vasoactive properties of thienopyridine-derived nitrosothiols. Journal of Cardiovascular Pharmacology 58 (5), pp.550-558. (10.1097/FJC.0b013e31822f578c)
2010
- Caddy, J. et al., 2010. Rosiglitazone induces the unfolded protein response, but has no significant effect on cell viability, in monocytic and vascular smooth muscle cells. Biochemical and Biophysical Research Communications 400 (4), pp.689-695. (10.1016/j.bbrc.2010.08.129)
- Matthews, I. P. et al. 2010. Effects of emissions from different type of residential heating upon cyclic guanosine monophosphate (cGMP) in blood platelets of residents. Biomarkers 15 (1), pp.86-93. (10.3109/13547500903311894)
2009
- Lang, D. and James, P. E. 2009. Free nitric oxide in spent CAPD fluid: a leap of faith?. Peritoneal Dialysis International 29 (5), pp.505-507.
2008
- Caddy, J. et al., 2008. Rosiglitazone transiently disturbs calcium homeostasis in monocytic cells. Biochemical and Biophysical Research Communications 366 (1), pp.149-155. (10.1016/j.bbrc.2007.11.095)
2006
- Clarke, Z. L. et al., 2006. Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia. European Journal of Pharmacology 551 (1-3), pp.92-97. (10.1016/j.ejphar.2006.08.085)
- Moat, S. J. et al. 2006. High- but not low-dose folic acid improves endothelial function in coronary artery disease. European Journal Of Clinical Investigation 36 (12), pp.850-859. (10.1111/j.1365-2362.2006.01739.x)
- Moat, S. J. et al. 2006. Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis. European Journal of Pharmacology 530 (3), pp.250-258. (10.1016/j.ejphar.2005.11.047)
2004
- Van Den Berg, C. W. , Taylor, K. E. and Lang, D. 2004. C-reactive protein-induced in vitro vasorelaxation is an artefact caused by the presence of sodium azide in commercial preparations. Arteriosclerosis Thrombosis and Vascular Biology 24 (10), pp.e168-171. (10.1161/01.ATV.0000142807.92781.d9)
- James, P. E. et al. 2004. Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobin. Circulation Research 94 (7), pp.976-983. (10.1161/01.RES.0000122044.21787.01)
2001
- Doshi, S. N. et al., 2001. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arteriosclerosis Thrombosis and Vascular Biology 21 (7), pp.1196-1202. (10.1161/hq0701.092000)
1993
- Lang, D. , Warden-Smith, J. and Lewis, M. J. 1993. Induction of a calcium-independent NO synthase by hypercholesterolaemia in the rabbit. British Journal of Pharmacology 108 (2), pp.290-292.
- Williams, J. et al. 1993. Plasma L-arginine levels in a rabbit model of hypercholesterolaemia. Biochemical Pharmacology 46 (11), pp.2097-2099. (10.1016/0006-2952(93)90653-E)
1990
- Warden-Smith, J. and Lang, D. 1990. Release of endothelium-derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in endothelial cell cyclic GMP content, is inhibited by a phorbol ester. British Journal of Pharmacology 99 (3), pp.565-71.
Erthyglau
- Tettey, L. , Umla-Runge, K. and Lang, D. 2025. Mental health decline of prematurely retired professional rugby players requires improved psychological support: a qualitative study of lived experiences. GLOBAL PSYCHIATRY ARCHIVES 8 (1), pp.42-59. (10.52095/gpa.2025.7565.1102)
- Davies, R. et al. 2021. The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis. Rheumatology 60 (6), pp.2852-2861. keaa725. (10.1093/rheumatology/keaa725)
- Williams, J. et al. 2016. Characterisation of Death Receptor 3 dependent aortic changes during inflammatory arthritis. Pharmacology Research & Perspectives 4 (4) e0024. (10.1002/prp2.240)
- Taylor, S. Y. et al. 2013. Folic acid modulates eNOS activity via effects on posttranslational modifications and protein–protein interactions. European Journal of Pharmacology 714 (1-3), pp.193-201. (10.1016/j.ejphar.2013.05.026)
- Dada, J. et al. 2013. Oxygen mediates vascular smooth muscle relaxation in hypoxia. PLoS ONE 8 (2) e57162. (10.1371/journal.pone.0057162)
- Reynolds, S. L. et al. 2012. Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9. British Journal of Pharmacology 167 (3), pp.505-514. (10.1111/j.1476-5381.2012.01988.x)
- Bundhoo, S. et al. 2011. Direct vasoactive properties of thienopyridine-derived nitrosothiols. Journal of Cardiovascular Pharmacology 58 (5), pp.550-558. (10.1097/FJC.0b013e31822f578c)
- Caddy, J. et al., 2010. Rosiglitazone induces the unfolded protein response, but has no significant effect on cell viability, in monocytic and vascular smooth muscle cells. Biochemical and Biophysical Research Communications 400 (4), pp.689-695. (10.1016/j.bbrc.2010.08.129)
- Matthews, I. P. et al. 2010. Effects of emissions from different type of residential heating upon cyclic guanosine monophosphate (cGMP) in blood platelets of residents. Biomarkers 15 (1), pp.86-93. (10.3109/13547500903311894)
- Lang, D. and James, P. E. 2009. Free nitric oxide in spent CAPD fluid: a leap of faith?. Peritoneal Dialysis International 29 (5), pp.505-507.
- Caddy, J. et al., 2008. Rosiglitazone transiently disturbs calcium homeostasis in monocytic cells. Biochemical and Biophysical Research Communications 366 (1), pp.149-155. (10.1016/j.bbrc.2007.11.095)
- Clarke, Z. L. et al., 2006. Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia. European Journal of Pharmacology 551 (1-3), pp.92-97. (10.1016/j.ejphar.2006.08.085)
- Moat, S. J. et al. 2006. High- but not low-dose folic acid improves endothelial function in coronary artery disease. European Journal Of Clinical Investigation 36 (12), pp.850-859. (10.1111/j.1365-2362.2006.01739.x)
- Moat, S. J. et al. 2006. Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis. European Journal of Pharmacology 530 (3), pp.250-258. (10.1016/j.ejphar.2005.11.047)
- Van Den Berg, C. W. , Taylor, K. E. and Lang, D. 2004. C-reactive protein-induced in vitro vasorelaxation is an artefact caused by the presence of sodium azide in commercial preparations. Arteriosclerosis Thrombosis and Vascular Biology 24 (10), pp.e168-171. (10.1161/01.ATV.0000142807.92781.d9)
- James, P. E. et al. 2004. Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobin. Circulation Research 94 (7), pp.976-983. (10.1161/01.RES.0000122044.21787.01)
- Doshi, S. N. et al., 2001. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arteriosclerosis Thrombosis and Vascular Biology 21 (7), pp.1196-1202. (10.1161/hq0701.092000)
- Lang, D. , Warden-Smith, J. and Lewis, M. J. 1993. Induction of a calcium-independent NO synthase by hypercholesterolaemia in the rabbit. British Journal of Pharmacology 108 (2), pp.290-292.
- Williams, J. et al. 1993. Plasma L-arginine levels in a rabbit model of hypercholesterolaemia. Biochemical Pharmacology 46 (11), pp.2097-2099. (10.1016/0006-2952(93)90653-E)
- Warden-Smith, J. and Lang, D. 1990. Release of endothelium-derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in endothelial cell cyclic GMP content, is inhibited by a phorbol ester. British Journal of Pharmacology 99 (3), pp.565-71.
Addysgu
Rwy'n addysgu amrywiaeth eang o bynciau ar draws pob blwyddyn o'r rhaglen BSc Ffarmacoleg Feddygol. Er enghraifft, Ffarmacoleg System Nerfol Awtonomig ym Mlwyddyn 1, Ffarmacoleg Clefydau Trofannol ym Mlwyddyn 2, Ffarmacoleg Clefyd Cardiofasgwlaidd yn y flwyddyn olaf a llawer mwy rhyngddynt.
Rwy'n Uwch Gymrawd yr Academi Addysg Uwch (AdvanceHE).