Overview
Major Research Interests:
The foundations of my research were based in the field of endothelial and vascular smooth muscle cell biology. My particular interest was in the mechanisms that underlie endothelial/vascular dysfunction in various cardiovascular disease states. Have been actively "hands on" for many years, I now follow a Teaching and Scholarship pathway. I am very proud to have been promoted to Professor via this route in 2020. Importantly my previous research and continued interest in the field fuel my research-led teaching.
Having taught on the course for more years than I care to remember, I have been Director of the BSc Medical Pharmacology course at School of Medicine for over 10 years. Over that time the programme has gone from strength to strength. We help to develop highly skilled graduates that go on to successful roles in various sectors from Graduate Entry Medicine and Dentistry to the Pharmaceutical Industry and beyond.
I lead a small group of very dedicated professional educators. Our repeated high returns in the National Student Survery relfect their huge efforts in empowering out learning partners to become the best graduates they can be.
I try to maintain close links with the British Pharmacological Society, of which I am a Fellow.
Publication
2021
- Davies, R. et al. 2021. The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis. Rheumatology 60(6), pp. 2852-2861., article number: keaa725. (10.1093/rheumatology/keaa725)
2016
- Williams, J., Wang, E. C. Y., Lang, D. and Williams, A. S. 2016. Characterisation of Death Receptor 3 dependent aortic changes during inflammatory arthritis. Pharmacology Research & Perspectives 4(4), article number: e0024. (10.1002/prp2.240)
2013
- Taylor, S. Y., Dixon, H. M., Yoganayagam, S., Price, N. and Lang, D. 2013. Folic acid modulates eNOS activity via effects on posttranslational modifications and protein–protein interactions. European Journal of Pharmacology 714(1-3), pp. 193-201. (10.1016/j.ejphar.2013.05.026)
- Dada, J., Pinder, A. G., Lang, D. and James, P. E. 2013. Oxygen mediates vascular smooth muscle relaxation in hypoxia. PLoS ONE 8(2), article number: e57162. (10.1371/journal.pone.0057162)
2012
- Reynolds, S. L. et al. 2012. Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9. British Journal of Pharmacology 167(3), pp. 505-514. (10.1111/j.1476-5381.2012.01988.x)
2011
- Bundhoo, S. et al. 2011. Direct vasoactive properties of thienopyridine-derived nitrosothiols. Journal of Cardiovascular Pharmacology 58(5), pp. 550-558. (10.1097/FJC.0b013e31822f578c)
2010
- Caddy, J. et al. 2010. Rosiglitazone induces the unfolded protein response, but has no significant effect on cell viability, in monocytic and vascular smooth muscle cells. Biochemical and Biophysical Research Communications 400(4), pp. 689-695. (10.1016/j.bbrc.2010.08.129)
- Matthews, I. P., Henderson, K. A., Gregory, C. J., Palmer, S. R. and Lang, D. 2010. Effects of emissions from different type of residential heating upon cyclic guanosine monophosphate (cGMP) in blood platelets of residents. Biomarkers 15(1), pp. 86-93. (10.3109/13547500903311894)
2009
- Lang, D. and James, P. E. 2009. Free nitric oxide in spent CAPD fluid: a leap of faith?. Peritoneal Dialysis International 29(5), pp. 505-507.
2008
- Caddy, J. et al. 2008. Rosiglitazone transiently disturbs calcium homeostasis in monocytic cells. Biochemical and Biophysical Research Communications 366(1), pp. 149-155. (10.1016/j.bbrc.2007.11.095)
2006
- Clarke, Z. L., Moat, S. J., Miller, A. L., Randall, M. D., Lewis, M. J. and Lang, D. 2006. Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia. European Journal of Pharmacology 551(1-3), pp. 92-97. (10.1016/j.ejphar.2006.08.085)
- Moat, S. J. et al. 2006. High- but not low-dose folic acid improves endothelial function in coronary artery disease. European Journal Of Clinical Investigation 36(12), pp. 850-859. (10.1111/j.1365-2362.2006.01739.x)
- Moat, S. J., Clarke, Z. L., Madhavan, A. K., Lewis, M. J. and Lang, D. 2006. Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis. European Journal of Pharmacology 530(3), pp. 250-258. (10.1016/j.ejphar.2005.11.047)
2004
- Van Den Berg, C. W., Taylor, K. E. and Lang, D. 2004. C-reactive protein-induced in vitro vasorelaxation is an artefact caused by the presence of sodium azide in commercial preparations. Arteriosclerosis Thrombosis and Vascular Biology 24(10), pp. e168-171. (10.1161/01.ATV.0000142807.92781.d9)
- James, P. E., Lang, D., Tufnell-Barret, T., Milsom, A. B. and Frenneaux, M. P. 2004. Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobin. Circulation Research 94(7), pp. 976-983. (10.1161/01.RES.0000122044.21787.01)
2001
- Doshi, S. N. et al. 2001. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arteriosclerosis Thrombosis and Vascular Biology 21(7), pp. 1196-1202. (10.1161/hq0701.092000)
1993
- Lang, D., Warden-Smith, J. and Lewis, M. J. 1993. Induction of a calcium-independent NO synthase by hypercholesterolaemia in the rabbit. British Journal of Pharmacology 108(2), pp. 290-292.
- Williams, J., Lang, D., Warden-Smith, J. and Lewis, M. J. 1993. Plasma L-arginine levels in a rabbit model of hypercholesterolaemia. Biochemical Pharmacology 46(11), pp. 2097-2099. (10.1016/0006-2952(93)90653-E)
1990
- Warden-Smith, J. and Lang, D. 1990. Release of endothelium-derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in endothelial cell cyclic GMP content, is inhibited by a phorbol ester. British Journal of Pharmacology 99(3), pp. 565-71.
Articles
- Davies, R. et al. 2021. The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis. Rheumatology 60(6), pp. 2852-2861., article number: keaa725. (10.1093/rheumatology/keaa725)
- Williams, J., Wang, E. C. Y., Lang, D. and Williams, A. S. 2016. Characterisation of Death Receptor 3 dependent aortic changes during inflammatory arthritis. Pharmacology Research & Perspectives 4(4), article number: e0024. (10.1002/prp2.240)
- Taylor, S. Y., Dixon, H. M., Yoganayagam, S., Price, N. and Lang, D. 2013. Folic acid modulates eNOS activity via effects on posttranslational modifications and protein–protein interactions. European Journal of Pharmacology 714(1-3), pp. 193-201. (10.1016/j.ejphar.2013.05.026)
- Dada, J., Pinder, A. G., Lang, D. and James, P. E. 2013. Oxygen mediates vascular smooth muscle relaxation in hypoxia. PLoS ONE 8(2), article number: e57162. (10.1371/journal.pone.0057162)
- Reynolds, S. L. et al. 2012. Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9. British Journal of Pharmacology 167(3), pp. 505-514. (10.1111/j.1476-5381.2012.01988.x)
- Bundhoo, S. et al. 2011. Direct vasoactive properties of thienopyridine-derived nitrosothiols. Journal of Cardiovascular Pharmacology 58(5), pp. 550-558. (10.1097/FJC.0b013e31822f578c)
- Caddy, J. et al. 2010. Rosiglitazone induces the unfolded protein response, but has no significant effect on cell viability, in monocytic and vascular smooth muscle cells. Biochemical and Biophysical Research Communications 400(4), pp. 689-695. (10.1016/j.bbrc.2010.08.129)
- Matthews, I. P., Henderson, K. A., Gregory, C. J., Palmer, S. R. and Lang, D. 2010. Effects of emissions from different type of residential heating upon cyclic guanosine monophosphate (cGMP) in blood platelets of residents. Biomarkers 15(1), pp. 86-93. (10.3109/13547500903311894)
- Lang, D. and James, P. E. 2009. Free nitric oxide in spent CAPD fluid: a leap of faith?. Peritoneal Dialysis International 29(5), pp. 505-507.
- Caddy, J. et al. 2008. Rosiglitazone transiently disturbs calcium homeostasis in monocytic cells. Biochemical and Biophysical Research Communications 366(1), pp. 149-155. (10.1016/j.bbrc.2007.11.095)
- Clarke, Z. L., Moat, S. J., Miller, A. L., Randall, M. D., Lewis, M. J. and Lang, D. 2006. Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia. European Journal of Pharmacology 551(1-3), pp. 92-97. (10.1016/j.ejphar.2006.08.085)
- Moat, S. J. et al. 2006. High- but not low-dose folic acid improves endothelial function in coronary artery disease. European Journal Of Clinical Investigation 36(12), pp. 850-859. (10.1111/j.1365-2362.2006.01739.x)
- Moat, S. J., Clarke, Z. L., Madhavan, A. K., Lewis, M. J. and Lang, D. 2006. Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis. European Journal of Pharmacology 530(3), pp. 250-258. (10.1016/j.ejphar.2005.11.047)
- Van Den Berg, C. W., Taylor, K. E. and Lang, D. 2004. C-reactive protein-induced in vitro vasorelaxation is an artefact caused by the presence of sodium azide in commercial preparations. Arteriosclerosis Thrombosis and Vascular Biology 24(10), pp. e168-171. (10.1161/01.ATV.0000142807.92781.d9)
- James, P. E., Lang, D., Tufnell-Barret, T., Milsom, A. B. and Frenneaux, M. P. 2004. Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobin. Circulation Research 94(7), pp. 976-983. (10.1161/01.RES.0000122044.21787.01)
- Doshi, S. N. et al. 2001. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arteriosclerosis Thrombosis and Vascular Biology 21(7), pp. 1196-1202. (10.1161/hq0701.092000)
- Lang, D., Warden-Smith, J. and Lewis, M. J. 1993. Induction of a calcium-independent NO synthase by hypercholesterolaemia in the rabbit. British Journal of Pharmacology 108(2), pp. 290-292.
- Williams, J., Lang, D., Warden-Smith, J. and Lewis, M. J. 1993. Plasma L-arginine levels in a rabbit model of hypercholesterolaemia. Biochemical Pharmacology 46(11), pp. 2097-2099. (10.1016/0006-2952(93)90653-E)
- Warden-Smith, J. and Lang, D. 1990. Release of endothelium-derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in endothelial cell cyclic GMP content, is inhibited by a phorbol ester. British Journal of Pharmacology 99(3), pp. 565-71.
Teaching
I teach a wide variety of topics across all years of the Medical Pharmacology BSc programme. For example Autonomic Nervous System Pharmacology in Year 1, Tropical Disease Pharmacology in Year 2, Cardiovascular Disease Pharmacology in the final year and much more in between.
I am a Senior Fellow of the Higher Education Academy (AdvanceHE).