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Dr Kate Langley
Senior Lecturer
- LangleyK@caerdydd.ac.uk
- +44 29208 76259
- Adeilad y Tŵr, Plas y Parc, Caerdydd, CF10 3AT
Trosolwyg
Crynodeb ymchwil
Gall problemau iechyd meddwl yn ystod plentyndod arwain at ganlyniadau pellgyrhaeddol i'r unigolyn, ei deulu a'i gymdeithas. Mae gennyf ddiddordeb mewn ffactorau risg ar gyfer problemau o'r fath, yn benodol Anhwylder Gorfywiogrwydd Diffyg Canolbwyntio (ADHD), Anhwylder Ymddygiad a phroblemau cyd-ddigwydd (megis Anhwylderau Sbectrwm Awtistiaeth ). Mae gen i ddiddordeb hefyd yn sut mae cyflwyno'r problemau hyn yn newid gydag oedran a sut mae gwahanol ffactorau risg yn gysylltiedig â chwrs datblygu anhrefn.
Crynodeb addysgu
Ar hyn o bryd rwy'n addysgu ar Seicoleg Ddatblygiadol o fewn y rhaglen Israddedig 2il Flwyddyn. Rwyf hefyd yn addysgu ar yr MSc mewn Anhwylderau Seicolegol Plant ac rwy'n gydlynydd modiwl ar gyfer y modiwlau Anhwylderau Niwroddatblygiadol 1: Niwrofioleg.
Cyhoeddiad
2024
- Anning, K. L., Langley, K., Hobson, C. and van Goozen, S. H. 2024. Cool and hot executive function problems in young children: Linking self-regulation processes to emerging clinical symptoms. European Child and Adolescent Psychiatry 33, pp. 2705-2718. (10.1007/s00787-023-02344-z)
- Martin, J. et al. 2024. Sex differences in ADHD diagnosis and clinical care: A national study of population healthcare records in Wales. Journal of Child Psychology and Psychiatry (10.1111/jcpp.13987)
- Anning, K. L., Langley, K., Hobson, C., De Sonneville, L. and Van Goozen, S. H. 2024. Inattention symptom severity and cognitive processes in children at risk of ADHD: The moderating role of separation anxiety. Child Neuropsychology 30(2), pp. 264-288. (10.1080/09297049.2023.2190964)
- Agha, S. S. et al. 2024. Young adult ADHD symptoms in the general population and neurocognitive impairment. Journal of Attention Disorders 28(1), pp. 89-98. (10.1177/10870547231201870)
2023
- Gosling, C. J. et al. 2023. Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis. The Lancet Psychiatry 10(12), pp. 922-933. (10.1016/S2215-0366(23)00272-9)
- Wang, S. et al. 2023. Rare X-linked variants carry predominantly male risk in Autism, Tourette Syndrome, and ADHD. Nature Communications 14, article number: 8077. (10.1038/s41467-023-43776-0)
- Anning, K. L., Langley, K., Hobson, C. and Van Goozen, S. H. M. 2023. Dimensional associations between executive function processes and symptoms of ADHD, ASD, oppositional defiance and anxiety in young school-referred children. Cortex 167, pp. 132-147. (10.1016/j.cortex.2023.06.005)
- Langley, K., Pozo-Banos, M., Daalsgard, S., Paranjothy, S., Riglin, L., John, A. and Thapar, A. 2023. Can a nation-wide e-cohort of ADHD and ASD in childhood be established using Welsh routinely available datasets?. BMJ Open 13, article number: e071851. (10.1136/bmjopen-2023-071851)
- Lewis, K., Martin, J., Gregory, A. M., Anney, R., Thapar, A. and Langley, K. 2023. Sleep disturbances in ADHD: Investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes. European Child and Adolescent Psychiatry 32, pp. 1253-1261. (10.1007/s00787-021-01931-2)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Broughton, T., Langley, K., Tilling, K. and Collishaw, S. 2023. Relative age in the school year and risk of mental health problems in childhood, adolescence, and young adulthood. Journal of Child Psychology and Psychiatry 64(1), pp. 185-196. (10.1111/jcpp.13684)
- Martin, J. et al. 2023. Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios. Biological Psychiatry 93(1), pp. 37-44. (10.1016/j.biopsych.2022.06.008)
2022
- Riglin, L. et al. 2022. Early manifestations of genetic liability for ADHD, autism and schizophrenia at ages 18 and 24 months. JCPP Advances 2(3), article number: e12093. (10.1002/jcv2.12093)
- Tobarra‐Sanchez, E., Riglin, L., Agha, S. S., Stergiakouli, E., Thapar, A. and Langley, K. 2022. Preschool development, temperament and genetic liability as early markers of childhood ADHD: A cohort study. JCPP Advances 2(3), article number: e12099. (10.1002/jcv2.12099)
- Riglin, L. et al. 2022. “Late-onset” ADHD symptoms in young adulthood: is this the same as child-onset ADHD?. Journal of Attention Disorders 26(10), pp. 1271-1282. (10.1177/10870547211066486)
- Dingsdale, H. et al. 2022. Cord serum brain-derived neurotrophic factor levels at birth associate with temperament outcomes at one year. Journal of Psychiatric Research 150, article number: 47-53. (10.1016/j.jpsychires.2022.03.009)
- Adegboye, D. et al. 2022. Understanding de novo onset of anxiety during COVID-19: Pre-pandemic socio-emotional functioning in vulnerable children. JCPP Advances 2(2), article number: e12076. (10.1002/jcv2.12076)
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention-deficit hyperactivity disorder. In: Stanford, S. C. and Sciberras, E. eds. Current Topics in Behavioral Neurosciences. Berlin, Heidelberg: Springer, pp. 1-26., (10.1007/7854_2022_338)
- Cooper, M., Gale, K., Langley, K., Broughton, T., Massey, T. H., Hall, N. J. and Jones, C. R. 2022. How to do it: the neurological consultation with an autistic patient. Practical Neurology 22, pp. 120-125. (10.1136/practneurol-2020-002856)
- Turnock, A., Langley, K. and Jones, C. R. 2022. Understanding stigma in autism: a narrative review and theoretical model. Autism in Adulthood 4(1), pp. 76-91. (10.1089/aut.2021.0005)
- Colonna, S., Eyre, O., Agha, S. S., Thapar, A., van Goozen, S. and Langley, K. 2022. Investigating the associations between irritability and hot and cool executive functioning in those with ADHD. BMC Psychiatry 22, article number: 166. (10.1186/s12888-022-03818-1)
- Riglin, L. et al. 2022. Assessment of age-at-onset criterion for adult attention-deficit hyperactivity disorder. British Journal of Psychiatry 220(2), pp. 73-75. (10.1192/bjp.2021.122)
- Warne, N. et al. 2022. Collecting genetic samples and linked mental health data from adolescents in schools: protocol co-production and a mixed-methods pilot of feasibility and acceptability. BMJ Open 12(2), article number: e049283. (10.1136/bmjopen-2021-049283)
- van Goozen, S. H. M., Langley, K. and Hobson, C. W. 2022. Childhood antisocial behavior: a neurodevelopmental problem. Annual Review of Psychology 73, pp. 353-377. (10.1146/annurev-psych-052621-045243)
- Wimberley, T. et al. 2022. Early-life injuries and the development of attention-deficit/hyperactivity disorder. Journal of Clinical Psychiatry 83(1) (10.4088/JCP.21m14033)
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention deficit hyperactivity disorder. Springer Nature.
2021
- Eyre, O. et al. 2021. Validation of the short Mood and Feelings Questionnaire in young adulthood. Journal of Affective Disorders 294, pp. 883-888. (10.1016/j.jad.2021.07.090)
- Martin, J. et al. 2021. Sex differences in anxiety and depression in children with ADHD investigating genetic liability and comorbidity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186(7), pp. 412-422. (10.1002/ajmg.b.32842)
- Riglin, L. et al. 2021. Variable emergence of Autism Spectrum Disorder symptoms from childhood to early adulthood. American Journal of Psychiatry 178(8), pp. 752-760. (10.1176/appi.ajp.2020.20071119)
- Riglin, L. et al. 2021. Investigating the validity of the strengths and difficulties questionnaire to assess ADHD in young adulthood. Psychiatry Research 301, article number: 113984. (10.1016/j.psychres.2021.113984)
- Riglin, L. et al. 2021. Investigating attention‐deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life?. Journal of Child Psychology and Psychiatry 62(4), pp. 449-457. (10.1111/jcpp.13297)
- Adegboye, D. et al. 2021. Understanding why the COVID-19 pandemic-related lockdown increases mental health difficulties in vulnerable young children. Journal of Child Psychology and Psychiatry Advances 1(1), article number: e12005. (10.1111/jcv2.12005)
2020
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2020. Parent psychopathology and neurocognitive functioning in children with ADHD. Journal of Attention Disorders 24(13), pp. 1836-1846. (10.1177/1087054717718262)
- Wimberle, T. et al. 2020. Genetic liability to ADHD and substance use disorders in individuals with ADHD. Addiction 115(7), pp. 1368-1377. (10.1111/add.14910)
- Martin, J. et al. 2020. A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder. Translational Psychiatry 10, article number: 135. (10.1038/s41398-020-0821-y)
- Hales, C. et al. 2020. Controlled antenatal thyroid screening II: Effect of treating maternal sub-optimal thyroid function on child behaviour. Journal of Clinical Endocrinology and Metabolism 105(3), article number: dgz098. (10.1210/clinem/dgz098)
- Fry, C., Langley, K. and Shelton, K. 2020. Executive functions in homeless young people: working memory impacts on short-term housing outcomes. Child Neuropsychology 26(1), pp. 27-53. (10.1080/09297049.2019.1628930)
- Caye, A. et al. 2020. A risk calculator to predict adult Attention-Deficit/Hyperactivity Disorder: generation and external validation in three birth cohorts and one clinical sample. Epidemiology and Psychiatric Sciences 29, article number: e37. (10.1017/S2045796019000283)
2019
- Lee, P. H. et al. 2019. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7), pp. 1469-1482.e11. (10.1016/j.cell.2019.11.020)
- Demontis, D. et al. 2019. Discovery of the first genome-wide significant risk loci for attention-deficit/hyperactivity disorder. Nature Genetics 51, pp. 63-75. (10.1038/s41588-018-0269-7)
2018
- Cooper, M. et al. 2018. Investigating late-onset ADHD: a population cohort investigation. Journal of Child Psychology and Psychiatry 59(10), pp. 1105-1113. (10.1111/jcpp.12911)
- Airdrie, J. N., Langley, K., Thapar, A. and van Goozen, S. H. M. 2018. Facial emotion recognition and eye gaze in attention-deficit/hyperactivity disorder with and without comorbid conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry 57(8), pp. 561-570. (10.1016/j.jaac.2018.04.016)
- Rice, F., Langley, K., Woodford, C., Davey Smith, G. and Thapar, A. 2018. Identifying the contribution of prenatal risk factors to offspring development and psychopathology: What designs to use and a critique of literature on maternal smoking and stress in pregnancy. Development and Psychopathology 30(3), pp. 1107-1128. (10.1017/S0954579418000421)
- Anttila, V. et al. 2018. Analysis of shared heritability in common disorders of the brain. Science 360(6395), article number: eaap8757. (10.1126/science.aap8757)
- Hurt, L., Langley, K., North, K., Southern, A., Copeland, L., Gillard, J. and Williams, S. J. 2018. Understanding and improving the care pathway for children with autism. International Journal of Health Care Quality Assurance 32(1), pp. 208-223. (10.1108/IJHCQA-08-2017-0153)
2017
- Riglin, L. et al. 2017. Investigating the genetic underpinnings of early-life irritability. Translational Psychiatry 7, article number: e1241. (10.1038/tp.2017.212)
- Langley, K., Collishaw, S., Williams, M. and Shelton, K. H. 2017. An investigation of changes in children′s mental health in Wales between 2007/2008 and 2012/2013. Social Psychiatry and Psychiatric Epidemiology 52, pp. 639-642. (10.1007/s00127-017-1378-9)
- Eyre, O., Langley, K., Stringaris, A., Leibenluft, E., Collishaw, S. and Thapar, A. 2017. Irritability in ADHD: Associations with depression liability. Journal of Affective Disorders 215, pp. 281-287. (10.1016/j.jad.2017.03.050)
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2017. Maternal psychopathology and offspring clinical outcome: a four-year follow-up of boys with ADHD. European Child and Adolescent Psychiatry 26(2), pp. 253-262. (10.1007/s00787-016-0873-y)
- Gustavson, K. et al. 2017. Smoking in pregnancy and child ADHD. Pediatrics 139(2), pp. e20162509. (10.1542/peds.2016-2509)
- Fry, C., Langley, K. and Shelton, K. H. 2017. A systematic review of cognitive functioning among young people who have experienced homelessness, foster care, or poverty. Child Neuropsychology 23(8), pp. 907-934. (10.1080/09297049.2016.1207758)
2016
- Riglin, L. et al. 2016. Association of genetic risk variants with attention-deficit/hyperactivity disorder trajectories in the general population. JAMA Psychiatry 73(12), pp. 1285-1292. (10.1001/jamapsychiatry.2016.2817)
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
- Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
- Northover, C., Thapar, A., Langley, K., Fairchild, G. and Van Goozen, S. H. M. 2016. Cortisol levels at baseline and under stress in adolescent males with Attention-Deficit Hyperactivity Disorder, with or without comorbid Conduct Disorder. Psychiatry Research 242, pp. 130-136. (10.1016/j.psychres.2016.05.052)
- Riglin, L., Thapar, A., Shelton, K. H., Langley, K., Frederickson, N. and Rice, F. 2016. Profiling depression in childhood and adolescence: the role of conduct problems. Journal of Child Psychology and Psychiatry 57(4), pp. 481-490. (10.1111/jcpp.12465)
- van Goozen, S. H. M. et al. 2016. Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD. Journal of Child Psychology and Psychiatry 57(4), pp. 472-480. (10.1111/jcpp.12464)
- Sellers, R. et al. 2016. Examining whether offspring psychopathology influences illness course in mothers with recurrent depression using a high-risk longitudinal sample. Journal of Abnormal Psychology 125(2), pp. 256-266. (10.1037/abn0000080)
2015
- Northover, C., Thapar, A., Langley, K. and van Goozen, S. H. M. 2015. Emotion regulation in adolescent males with attention-deficit hyperactivity disorder: testing the effects of comorbid conduct disorder. Brain Sciences 5(3), pp. 369-386. (10.3390/brainsci5030369)
- Northover, C., Thapar, A., Langley, K. and Van Goozen, S. H. M. 2015. Pain sensitivity in adolescent males with Attention-Deficit/Hyperactivity Disorder: Testing for associations with conduct disorder and callous and unemotional traits. PloS ONE 10(7), article number: e0134417. (10.1371/journal.pone.0134417)
- Stergiakouli, E. et al. 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54(4), pp. 322-327. (10.1016/j.jaac.2015.01.010)
- Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5, article number: e506. (10.1038/tp.2015.5)
2014
- Cooper, M., Langley, K. and Thapar, A. 2014. Antenatal Acetaminophen use and attention-deficit/hyperactivity disorder. JAMA Pediatrics 168(4), pp. 306-307. (10.1001/jamapediatrics.2013.5292)
- Langley, K. and Thapar, A. 2014. Commentary: Maternal pre-pregnancy BMI and offspring ADHD: a lesson in the importance of testing causal pathways. International Journal of Epidemiology 43(1), pp. 91-93. (10.1093/ije/dyt275)
- Cooper, M., Martin, J., Langley, K., Hamshere, M. L. and Thapar, A. 2014. Autistic traits in children with ADHD index clinical and cognitive problems. European Child & Adolescent Psychiatry 23(1), pp. 23-24. (10.1007/s00787-013-0398-6)
2013
- Ahuja, A., Martin, J., Langley, K. and Thapar, A. 2013. Intellectual disability in children with attention deficit hyperactivity disorder. The Journal of Pediatrics 163(3), pp. 890-895.e1. (10.1016/j.jpeds.2013.02.043)
- Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2013. Are parental ADHD problems associated with a more severe clinical presentation and greater family adversity in children with ADHD?. European Child & Adolescent Psychiatry 22(6), pp. 369-377. (10.1007/s00787-013-0378-x)
- Thapar, A., Langley, K. and Muñoz-Solomando, A. 2013. The ADHD debate: being mindful of complexity and wary of reductionist explanations and polarization: Commentary on 'A social relational critique of the biomedical definition and treatment of ADHD; ethical, practical and political implications'. Journal of Family Therapy 35(2), pp. 219-223. (10.1111/j.1467-6427.2012.00608.x)
- Telford, C., Green, C., Logan, S., Langley, K., Thapar, A. and Ford, T. 2013. Estimating the costs of ongoing care for adolescents with attention-deficit hyperactivity disorder. Social Psychiatry and Psychiatric Epidemiology 48(2), pp. 337-344. (10.1007/s00127-012-0530-9)
- Thapar, A., Cooper, M., Eyre, O. and Langley, K. 2013. Practitioner review: what have we learnt about the causes of ADHD?. Journal of Child Psychology and Psychiatry 54(1), pp. 3-16. (10.1111/j.1469-7610.2012.02611.x)
2012
- Langley, K., Heron, J., Davey-Smith, G. and Thapar, A. 2012. Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effects. American Journal of Epidemiology 176(3), pp. 261-268. (10.1093/aje/kwr510)
- Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169(2), pp. 186-194. (10.1176/appi.ajp.2011.11040551)
- Williams, N. M. et al. 2012. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. American Journal of Psychiatry 169(2), pp. 195-204. (10.1176/appi.ajp.2011.11060822)
2011
- Hinney, A. et al. 2011. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 888-897. (10.1002/ajmg.b.31246)
- Hassan, A., Agha, S. S., Langley, K. and Thapar, A. 2011. Prevalence of bipolar disorder in children and adolescents with attention-deficit hyperactivity disorder. British Journal of Psychiatry 198(3), pp. 195-198. (10.1192/bjp.bp.110.078741)
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.
2010
- Langley, K., Heron, J., O'Donovan, M. C., Owen, M. J. and Thapar, A. 2010. Genotype link with extreme antisocial behavior: The contribution of cognitive pathways. Archives of General Psychiatry 67(12), pp. 1317-1323. (10.1001/archgenpsychiatry.2010.163)
- Williams, N. M. et al. 2010. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376(9750), pp. 1401-1408. (10.1016/S0140-6736(10)61109-9)
- Thapar, A. et al. 2010. Response to: testing the association between smoking in pregnancy and attention-deficit/hyperactivity disorder in a novel design [Letter]. Biological psychiatry 68(4), pp. e13-e14. (10.1016/j.biopsych.2010.01.032)
- Langley, K. et al. 2010. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. British Journal of Psychiatry 196(3), pp. 235-240. (10.1192/bjp.bp.109.066274)
- Neale, B. M. et al. 2010. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49(9), pp. 884-897. (10.1016/j.jaac.2010.06.008)
2009
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19(6), pp. 312-319. (10.1097/YPG.0b013e3283328df4)
- Thapar, A. et al. 2009. Prenatal smoking might not cause Attention-Deficit/Hyperactivity Disorder: Evidence from a novel design. Biological Psychiatry 66(8), pp. 722-727. (10.1016/j.biopsych.2009.05.032)
- Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18(1), pp. 26-32. (10.1007/s00787-008-0698-4)
- Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194(1), pp. 62-67. (10.1192/bjp.bp.107.046870)
2008
- Ford, T., Fowler, T. A., Langley, K., Whittinger, N. S. and Thapar, A. 2008. Five years on: public sector service use related to mental health in young people with ADHD or hyperkinetic disorder five years after diagnosis. Child and Adolescent Mental Health 13(3), pp. 122-129. (10.1111/j.1475-3588.2007.00466.x)
- Caspi, A. et al. 2008. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 65(2), pp. 203-210. (10.1001/archgenpsychiatry.2007.24)
- Brookes, K. J. et al. 2008. Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 94-99. (10.1002/ajmg.b.30562)
- Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 49-53. (10.1002/ajmg.b.30571)
2007
- Thapar, A., Langley, K., Owen, M. J. and O'Donovan, M. C. 2007. Advances in genetic findings on attention deficit hyperactivity disorder. Psychological Medicine 37(12), pp. 1681-1692. (10.1017/S0033291707000773)
- Thapar, A., Harold, G. T., Rice, F., Langley, K. and O'Donovan, M. C. 2007. The contribution of gene-environment interaction to psychopathology. Development and Psychopathology 19(4), pp. 989-1004. (10.1017/S0954579407000491)
- Langley, K., Holmans, P. A., van den Bree, M. B. and Thapar, A. 2007. Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample. BMC Psychiatry 7(1), pp. 26-26. (10.1186/1471-244X-7-26)
- Whittinger, N., Langley, K., Fowler, T., Thomas, H. V. and Thapar, A. 2007. Clinical precursors of adolescent conduct disorder in children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry 46(2), pp. 179-187. (10.1097/01.chi.0000246066.00825.53)
- Thapar, A., Langley, K., Asherson, P. and Gill, M. 2007. Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective. British Journal of Psychiatry 190(1), pp. 1-3. (10.1192/bjp.bp.106.027003)
- Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64(3), pp. 378-379. (10.1001/archpsyc.64.3.378-b)
2006
- Thapar, A., Langley, K., O'Donovan, M. C. and Owen, M. J. 2006. Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies. Molecular Psychiatry 11(8), pp. 714-20. (10.1038/sj.mp.4001831)
- Thapar, A., van den Bree, M. B., Fowler, T., Langley, K. and Whittinger, N. 2006. Predictors of antisocial behaviour in children with attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 15(2), pp. 118-125. (10.1007/s00787-006-0511-1)
2005
- Langley, K., Rice, F., van den Bree, M. B. and Thapar, A. 2005. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review.. Minerva Pediatrica 57(6), pp. 359-371.
- Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B(1), pp. 7-10. (10.1002/ajmg.b.30206)
- Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62(11), pp. 1275-1278. (10.1001/archpsyc.62.11.1275)
- Stevenson, J., Langley, K., Pay, H., Payton, A., Worthington, J., Ollier, W. and Thapar, A. 2005. Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. Journal of Child Psychology and Psychiatry 46(10), pp. 1081-1088. (10.1111/j.1469-7610.2005.01533.x)
- Langley, K. 2005. A genetic study of attention deficit hyperactivity disorder: examining environmental influences and phenotypic variation.. PhD Thesis, Cardiff University.
- Turic, D. et al. 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57(11), pp. 1461-1466. (10.1016/j.biopsych.2005.03.025)
- Turic, D., Williams, H., Langley, K., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2005. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 133B(1), pp. 64-67. (10.1002/ajmg.b.30123)
- Potter, R., Langley, K. and Sakhuja, D. 2005. All things to all people: what referrers want from their child and adolescent mental health service. Psychiatric Bulletin 29(7), pp. 262. (10.1192/pb.29.7.262)
- Kent, L. et al. 2005. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Molecular Psychiatry 10(10), pp. 939-943. (10.1038/sj.mp.4001696)
2004
- Fowler, T. A. et al. 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 98-98. (10.1002/ajmg.b.30101)
- Mills, S. et al. 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4, pp. 15-15. (10.1186/1471-244X-4-15)
- Turic, D., Langley, K., Kirov, G., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2004. Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD. American Journal of Medical Genetics 127B(1), pp. 68-72. (10.1002/ajmg.b.20173)
- Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J., O'Donovan, M. C. and Thapar, A. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161(1), pp. 133-138. (10.1176/appi.ajp.161.1.133)
- Holmes, J. et al. 2004. The Child Attention-Deficit Hyperactivity Disorder Teacher Telephone Interview (CHATTI): reliability and validity. British Journal of Psychiatry 184(1), pp. 74-78. (10.1192/bjp.184.1.74)
- Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9(2), pp. 169-173. (10.1038/sj.mp.4001387)
2003
- Thapar, A., Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J. and O'Donovan, M. C. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33(6), pp. 721-721.
- Payton, A. et al. 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13(3), pp. 183-185.
- Langley, K. et al. 2003. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics 13(2), pp. 107-110. (10.1097/01.ypg.0000056177.32550.a5)
- Lawson, D. C. et al. 2003. Association analysis of monoamine oxidase a and attention deficit hyperactivity disorder. American Journal of Medical Genetics 116B(1), pp. 84-89. (10.1002/ajmg.b.10002)
2002
- West, A. et al. 2002. Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios. Molecular Psychiatry 7(9), pp. 962-966. (10.1038/sj.mp.4001129)
- Hawi, Z. et al. 2002. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Molecular Psychiatry 7(7), pp. 718-725. (10.1038/sj.mp.4001048)
Articles
- Anning, K. L., Langley, K., Hobson, C. and van Goozen, S. H. 2024. Cool and hot executive function problems in young children: Linking self-regulation processes to emerging clinical symptoms. European Child and Adolescent Psychiatry 33, pp. 2705-2718. (10.1007/s00787-023-02344-z)
- Martin, J. et al. 2024. Sex differences in ADHD diagnosis and clinical care: A national study of population healthcare records in Wales. Journal of Child Psychology and Psychiatry (10.1111/jcpp.13987)
- Anning, K. L., Langley, K., Hobson, C., De Sonneville, L. and Van Goozen, S. H. 2024. Inattention symptom severity and cognitive processes in children at risk of ADHD: The moderating role of separation anxiety. Child Neuropsychology 30(2), pp. 264-288. (10.1080/09297049.2023.2190964)
- Agha, S. S. et al. 2024. Young adult ADHD symptoms in the general population and neurocognitive impairment. Journal of Attention Disorders 28(1), pp. 89-98. (10.1177/10870547231201870)
- Gosling, C. J. et al. 2023. Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis. The Lancet Psychiatry 10(12), pp. 922-933. (10.1016/S2215-0366(23)00272-9)
- Wang, S. et al. 2023. Rare X-linked variants carry predominantly male risk in Autism, Tourette Syndrome, and ADHD. Nature Communications 14, article number: 8077. (10.1038/s41467-023-43776-0)
- Anning, K. L., Langley, K., Hobson, C. and Van Goozen, S. H. M. 2023. Dimensional associations between executive function processes and symptoms of ADHD, ASD, oppositional defiance and anxiety in young school-referred children. Cortex 167, pp. 132-147. (10.1016/j.cortex.2023.06.005)
- Langley, K., Pozo-Banos, M., Daalsgard, S., Paranjothy, S., Riglin, L., John, A. and Thapar, A. 2023. Can a nation-wide e-cohort of ADHD and ASD in childhood be established using Welsh routinely available datasets?. BMJ Open 13, article number: e071851. (10.1136/bmjopen-2023-071851)
- Lewis, K., Martin, J., Gregory, A. M., Anney, R., Thapar, A. and Langley, K. 2023. Sleep disturbances in ADHD: Investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes. European Child and Adolescent Psychiatry 32, pp. 1253-1261. (10.1007/s00787-021-01931-2)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Broughton, T., Langley, K., Tilling, K. and Collishaw, S. 2023. Relative age in the school year and risk of mental health problems in childhood, adolescence, and young adulthood. Journal of Child Psychology and Psychiatry 64(1), pp. 185-196. (10.1111/jcpp.13684)
- Martin, J. et al. 2023. Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios. Biological Psychiatry 93(1), pp. 37-44. (10.1016/j.biopsych.2022.06.008)
- Riglin, L. et al. 2022. Early manifestations of genetic liability for ADHD, autism and schizophrenia at ages 18 and 24 months. JCPP Advances 2(3), article number: e12093. (10.1002/jcv2.12093)
- Tobarra‐Sanchez, E., Riglin, L., Agha, S. S., Stergiakouli, E., Thapar, A. and Langley, K. 2022. Preschool development, temperament and genetic liability as early markers of childhood ADHD: A cohort study. JCPP Advances 2(3), article number: e12099. (10.1002/jcv2.12099)
- Riglin, L. et al. 2022. “Late-onset” ADHD symptoms in young adulthood: is this the same as child-onset ADHD?. Journal of Attention Disorders 26(10), pp. 1271-1282. (10.1177/10870547211066486)
- Dingsdale, H. et al. 2022. Cord serum brain-derived neurotrophic factor levels at birth associate with temperament outcomes at one year. Journal of Psychiatric Research 150, article number: 47-53. (10.1016/j.jpsychires.2022.03.009)
- Adegboye, D. et al. 2022. Understanding de novo onset of anxiety during COVID-19: Pre-pandemic socio-emotional functioning in vulnerable children. JCPP Advances 2(2), article number: e12076. (10.1002/jcv2.12076)
- Cooper, M., Gale, K., Langley, K., Broughton, T., Massey, T. H., Hall, N. J. and Jones, C. R. 2022. How to do it: the neurological consultation with an autistic patient. Practical Neurology 22, pp. 120-125. (10.1136/practneurol-2020-002856)
- Turnock, A., Langley, K. and Jones, C. R. 2022. Understanding stigma in autism: a narrative review and theoretical model. Autism in Adulthood 4(1), pp. 76-91. (10.1089/aut.2021.0005)
- Colonna, S., Eyre, O., Agha, S. S., Thapar, A., van Goozen, S. and Langley, K. 2022. Investigating the associations between irritability and hot and cool executive functioning in those with ADHD. BMC Psychiatry 22, article number: 166. (10.1186/s12888-022-03818-1)
- Riglin, L. et al. 2022. Assessment of age-at-onset criterion for adult attention-deficit hyperactivity disorder. British Journal of Psychiatry 220(2), pp. 73-75. (10.1192/bjp.2021.122)
- Warne, N. et al. 2022. Collecting genetic samples and linked mental health data from adolescents in schools: protocol co-production and a mixed-methods pilot of feasibility and acceptability. BMJ Open 12(2), article number: e049283. (10.1136/bmjopen-2021-049283)
- van Goozen, S. H. M., Langley, K. and Hobson, C. W. 2022. Childhood antisocial behavior: a neurodevelopmental problem. Annual Review of Psychology 73, pp. 353-377. (10.1146/annurev-psych-052621-045243)
- Wimberley, T. et al. 2022. Early-life injuries and the development of attention-deficit/hyperactivity disorder. Journal of Clinical Psychiatry 83(1) (10.4088/JCP.21m14033)
- Eyre, O. et al. 2021. Validation of the short Mood and Feelings Questionnaire in young adulthood. Journal of Affective Disorders 294, pp. 883-888. (10.1016/j.jad.2021.07.090)
- Martin, J. et al. 2021. Sex differences in anxiety and depression in children with ADHD investigating genetic liability and comorbidity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186(7), pp. 412-422. (10.1002/ajmg.b.32842)
- Riglin, L. et al. 2021. Variable emergence of Autism Spectrum Disorder symptoms from childhood to early adulthood. American Journal of Psychiatry 178(8), pp. 752-760. (10.1176/appi.ajp.2020.20071119)
- Riglin, L. et al. 2021. Investigating the validity of the strengths and difficulties questionnaire to assess ADHD in young adulthood. Psychiatry Research 301, article number: 113984. (10.1016/j.psychres.2021.113984)
- Riglin, L. et al. 2021. Investigating attention‐deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life?. Journal of Child Psychology and Psychiatry 62(4), pp. 449-457. (10.1111/jcpp.13297)
- Adegboye, D. et al. 2021. Understanding why the COVID-19 pandemic-related lockdown increases mental health difficulties in vulnerable young children. Journal of Child Psychology and Psychiatry Advances 1(1), article number: e12005. (10.1111/jcv2.12005)
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2020. Parent psychopathology and neurocognitive functioning in children with ADHD. Journal of Attention Disorders 24(13), pp. 1836-1846. (10.1177/1087054717718262)
- Wimberle, T. et al. 2020. Genetic liability to ADHD and substance use disorders in individuals with ADHD. Addiction 115(7), pp. 1368-1377. (10.1111/add.14910)
- Martin, J. et al. 2020. A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder. Translational Psychiatry 10, article number: 135. (10.1038/s41398-020-0821-y)
- Hales, C. et al. 2020. Controlled antenatal thyroid screening II: Effect of treating maternal sub-optimal thyroid function on child behaviour. Journal of Clinical Endocrinology and Metabolism 105(3), article number: dgz098. (10.1210/clinem/dgz098)
- Fry, C., Langley, K. and Shelton, K. 2020. Executive functions in homeless young people: working memory impacts on short-term housing outcomes. Child Neuropsychology 26(1), pp. 27-53. (10.1080/09297049.2019.1628930)
- Caye, A. et al. 2020. A risk calculator to predict adult Attention-Deficit/Hyperactivity Disorder: generation and external validation in three birth cohorts and one clinical sample. Epidemiology and Psychiatric Sciences 29, article number: e37. (10.1017/S2045796019000283)
- Lee, P. H. et al. 2019. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7), pp. 1469-1482.e11. (10.1016/j.cell.2019.11.020)
- Demontis, D. et al. 2019. Discovery of the first genome-wide significant risk loci for attention-deficit/hyperactivity disorder. Nature Genetics 51, pp. 63-75. (10.1038/s41588-018-0269-7)
- Cooper, M. et al. 2018. Investigating late-onset ADHD: a population cohort investigation. Journal of Child Psychology and Psychiatry 59(10), pp. 1105-1113. (10.1111/jcpp.12911)
- Airdrie, J. N., Langley, K., Thapar, A. and van Goozen, S. H. M. 2018. Facial emotion recognition and eye gaze in attention-deficit/hyperactivity disorder with and without comorbid conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry 57(8), pp. 561-570. (10.1016/j.jaac.2018.04.016)
- Rice, F., Langley, K., Woodford, C., Davey Smith, G. and Thapar, A. 2018. Identifying the contribution of prenatal risk factors to offspring development and psychopathology: What designs to use and a critique of literature on maternal smoking and stress in pregnancy. Development and Psychopathology 30(3), pp. 1107-1128. (10.1017/S0954579418000421)
- Anttila, V. et al. 2018. Analysis of shared heritability in common disorders of the brain. Science 360(6395), article number: eaap8757. (10.1126/science.aap8757)
- Hurt, L., Langley, K., North, K., Southern, A., Copeland, L., Gillard, J. and Williams, S. J. 2018. Understanding and improving the care pathway for children with autism. International Journal of Health Care Quality Assurance 32(1), pp. 208-223. (10.1108/IJHCQA-08-2017-0153)
- Riglin, L. et al. 2017. Investigating the genetic underpinnings of early-life irritability. Translational Psychiatry 7, article number: e1241. (10.1038/tp.2017.212)
- Langley, K., Collishaw, S., Williams, M. and Shelton, K. H. 2017. An investigation of changes in children′s mental health in Wales between 2007/2008 and 2012/2013. Social Psychiatry and Psychiatric Epidemiology 52, pp. 639-642. (10.1007/s00127-017-1378-9)
- Eyre, O., Langley, K., Stringaris, A., Leibenluft, E., Collishaw, S. and Thapar, A. 2017. Irritability in ADHD: Associations with depression liability. Journal of Affective Disorders 215, pp. 281-287. (10.1016/j.jad.2017.03.050)
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2017. Maternal psychopathology and offspring clinical outcome: a four-year follow-up of boys with ADHD. European Child and Adolescent Psychiatry 26(2), pp. 253-262. (10.1007/s00787-016-0873-y)
- Gustavson, K. et al. 2017. Smoking in pregnancy and child ADHD. Pediatrics 139(2), pp. e20162509. (10.1542/peds.2016-2509)
- Fry, C., Langley, K. and Shelton, K. H. 2017. A systematic review of cognitive functioning among young people who have experienced homelessness, foster care, or poverty. Child Neuropsychology 23(8), pp. 907-934. (10.1080/09297049.2016.1207758)
- Riglin, L. et al. 2016. Association of genetic risk variants with attention-deficit/hyperactivity disorder trajectories in the general population. JAMA Psychiatry 73(12), pp. 1285-1292. (10.1001/jamapsychiatry.2016.2817)
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
- Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
- Northover, C., Thapar, A., Langley, K., Fairchild, G. and Van Goozen, S. H. M. 2016. Cortisol levels at baseline and under stress in adolescent males with Attention-Deficit Hyperactivity Disorder, with or without comorbid Conduct Disorder. Psychiatry Research 242, pp. 130-136. (10.1016/j.psychres.2016.05.052)
- Riglin, L., Thapar, A., Shelton, K. H., Langley, K., Frederickson, N. and Rice, F. 2016. Profiling depression in childhood and adolescence: the role of conduct problems. Journal of Child Psychology and Psychiatry 57(4), pp. 481-490. (10.1111/jcpp.12465)
- van Goozen, S. H. M. et al. 2016. Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD. Journal of Child Psychology and Psychiatry 57(4), pp. 472-480. (10.1111/jcpp.12464)
- Sellers, R. et al. 2016. Examining whether offspring psychopathology influences illness course in mothers with recurrent depression using a high-risk longitudinal sample. Journal of Abnormal Psychology 125(2), pp. 256-266. (10.1037/abn0000080)
- Northover, C., Thapar, A., Langley, K. and van Goozen, S. H. M. 2015. Emotion regulation in adolescent males with attention-deficit hyperactivity disorder: testing the effects of comorbid conduct disorder. Brain Sciences 5(3), pp. 369-386. (10.3390/brainsci5030369)
- Northover, C., Thapar, A., Langley, K. and Van Goozen, S. H. M. 2015. Pain sensitivity in adolescent males with Attention-Deficit/Hyperactivity Disorder: Testing for associations with conduct disorder and callous and unemotional traits. PloS ONE 10(7), article number: e0134417. (10.1371/journal.pone.0134417)
- Stergiakouli, E. et al. 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54(4), pp. 322-327. (10.1016/j.jaac.2015.01.010)
- Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5, article number: e506. (10.1038/tp.2015.5)
- Cooper, M., Langley, K. and Thapar, A. 2014. Antenatal Acetaminophen use and attention-deficit/hyperactivity disorder. JAMA Pediatrics 168(4), pp. 306-307. (10.1001/jamapediatrics.2013.5292)
- Langley, K. and Thapar, A. 2014. Commentary: Maternal pre-pregnancy BMI and offspring ADHD: a lesson in the importance of testing causal pathways. International Journal of Epidemiology 43(1), pp. 91-93. (10.1093/ije/dyt275)
- Cooper, M., Martin, J., Langley, K., Hamshere, M. L. and Thapar, A. 2014. Autistic traits in children with ADHD index clinical and cognitive problems. European Child & Adolescent Psychiatry 23(1), pp. 23-24. (10.1007/s00787-013-0398-6)
- Ahuja, A., Martin, J., Langley, K. and Thapar, A. 2013. Intellectual disability in children with attention deficit hyperactivity disorder. The Journal of Pediatrics 163(3), pp. 890-895.e1. (10.1016/j.jpeds.2013.02.043)
- Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
- Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2013. Are parental ADHD problems associated with a more severe clinical presentation and greater family adversity in children with ADHD?. European Child & Adolescent Psychiatry 22(6), pp. 369-377. (10.1007/s00787-013-0378-x)
- Thapar, A., Langley, K. and Muñoz-Solomando, A. 2013. The ADHD debate: being mindful of complexity and wary of reductionist explanations and polarization: Commentary on 'A social relational critique of the biomedical definition and treatment of ADHD; ethical, practical and political implications'. Journal of Family Therapy 35(2), pp. 219-223. (10.1111/j.1467-6427.2012.00608.x)
- Telford, C., Green, C., Logan, S., Langley, K., Thapar, A. and Ford, T. 2013. Estimating the costs of ongoing care for adolescents with attention-deficit hyperactivity disorder. Social Psychiatry and Psychiatric Epidemiology 48(2), pp. 337-344. (10.1007/s00127-012-0530-9)
- Thapar, A., Cooper, M., Eyre, O. and Langley, K. 2013. Practitioner review: what have we learnt about the causes of ADHD?. Journal of Child Psychology and Psychiatry 54(1), pp. 3-16. (10.1111/j.1469-7610.2012.02611.x)
- Langley, K., Heron, J., Davey-Smith, G. and Thapar, A. 2012. Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effects. American Journal of Epidemiology 176(3), pp. 261-268. (10.1093/aje/kwr510)
- Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169(2), pp. 186-194. (10.1176/appi.ajp.2011.11040551)
- Williams, N. M. et al. 2012. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. American Journal of Psychiatry 169(2), pp. 195-204. (10.1176/appi.ajp.2011.11060822)
- Hinney, A. et al. 2011. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 888-897. (10.1002/ajmg.b.31246)
- Hassan, A., Agha, S. S., Langley, K. and Thapar, A. 2011. Prevalence of bipolar disorder in children and adolescents with attention-deficit hyperactivity disorder. British Journal of Psychiatry 198(3), pp. 195-198. (10.1192/bjp.bp.110.078741)
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.
- Langley, K., Heron, J., O'Donovan, M. C., Owen, M. J. and Thapar, A. 2010. Genotype link with extreme antisocial behavior: The contribution of cognitive pathways. Archives of General Psychiatry 67(12), pp. 1317-1323. (10.1001/archgenpsychiatry.2010.163)
- Williams, N. M. et al. 2010. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376(9750), pp. 1401-1408. (10.1016/S0140-6736(10)61109-9)
- Thapar, A. et al. 2010. Response to: testing the association between smoking in pregnancy and attention-deficit/hyperactivity disorder in a novel design [Letter]. Biological psychiatry 68(4), pp. e13-e14. (10.1016/j.biopsych.2010.01.032)
- Langley, K. et al. 2010. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. British Journal of Psychiatry 196(3), pp. 235-240. (10.1192/bjp.bp.109.066274)
- Neale, B. M. et al. 2010. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49(9), pp. 884-897. (10.1016/j.jaac.2010.06.008)
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19(6), pp. 312-319. (10.1097/YPG.0b013e3283328df4)
- Thapar, A. et al. 2009. Prenatal smoking might not cause Attention-Deficit/Hyperactivity Disorder: Evidence from a novel design. Biological Psychiatry 66(8), pp. 722-727. (10.1016/j.biopsych.2009.05.032)
- Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18(1), pp. 26-32. (10.1007/s00787-008-0698-4)
- Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194(1), pp. 62-67. (10.1192/bjp.bp.107.046870)
- Ford, T., Fowler, T. A., Langley, K., Whittinger, N. S. and Thapar, A. 2008. Five years on: public sector service use related to mental health in young people with ADHD or hyperkinetic disorder five years after diagnosis. Child and Adolescent Mental Health 13(3), pp. 122-129. (10.1111/j.1475-3588.2007.00466.x)
- Caspi, A. et al. 2008. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 65(2), pp. 203-210. (10.1001/archgenpsychiatry.2007.24)
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- Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 49-53. (10.1002/ajmg.b.30571)
- Thapar, A., Langley, K., Owen, M. J. and O'Donovan, M. C. 2007. Advances in genetic findings on attention deficit hyperactivity disorder. Psychological Medicine 37(12), pp. 1681-1692. (10.1017/S0033291707000773)
- Thapar, A., Harold, G. T., Rice, F., Langley, K. and O'Donovan, M. C. 2007. The contribution of gene-environment interaction to psychopathology. Development and Psychopathology 19(4), pp. 989-1004. (10.1017/S0954579407000491)
- Langley, K., Holmans, P. A., van den Bree, M. B. and Thapar, A. 2007. Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample. BMC Psychiatry 7(1), pp. 26-26. (10.1186/1471-244X-7-26)
- Whittinger, N., Langley, K., Fowler, T., Thomas, H. V. and Thapar, A. 2007. Clinical precursors of adolescent conduct disorder in children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry 46(2), pp. 179-187. (10.1097/01.chi.0000246066.00825.53)
- Thapar, A., Langley, K., Asherson, P. and Gill, M. 2007. Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective. British Journal of Psychiatry 190(1), pp. 1-3. (10.1192/bjp.bp.106.027003)
- Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64(3), pp. 378-379. (10.1001/archpsyc.64.3.378-b)
- Thapar, A., Langley, K., O'Donovan, M. C. and Owen, M. J. 2006. Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies. Molecular Psychiatry 11(8), pp. 714-20. (10.1038/sj.mp.4001831)
- Thapar, A., van den Bree, M. B., Fowler, T., Langley, K. and Whittinger, N. 2006. Predictors of antisocial behaviour in children with attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 15(2), pp. 118-125. (10.1007/s00787-006-0511-1)
- Langley, K., Rice, F., van den Bree, M. B. and Thapar, A. 2005. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review.. Minerva Pediatrica 57(6), pp. 359-371.
- Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B(1), pp. 7-10. (10.1002/ajmg.b.30206)
- Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62(11), pp. 1275-1278. (10.1001/archpsyc.62.11.1275)
- Stevenson, J., Langley, K., Pay, H., Payton, A., Worthington, J., Ollier, W. and Thapar, A. 2005. Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. Journal of Child Psychology and Psychiatry 46(10), pp. 1081-1088. (10.1111/j.1469-7610.2005.01533.x)
- Turic, D. et al. 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57(11), pp. 1461-1466. (10.1016/j.biopsych.2005.03.025)
- Turic, D., Williams, H., Langley, K., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2005. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 133B(1), pp. 64-67. (10.1002/ajmg.b.30123)
- Potter, R., Langley, K. and Sakhuja, D. 2005. All things to all people: what referrers want from their child and adolescent mental health service. Psychiatric Bulletin 29(7), pp. 262. (10.1192/pb.29.7.262)
- Kent, L. et al. 2005. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Molecular Psychiatry 10(10), pp. 939-943. (10.1038/sj.mp.4001696)
- Fowler, T. A. et al. 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 98-98. (10.1002/ajmg.b.30101)
- Mills, S. et al. 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4, pp. 15-15. (10.1186/1471-244X-4-15)
- Turic, D., Langley, K., Kirov, G., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2004. Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD. American Journal of Medical Genetics 127B(1), pp. 68-72. (10.1002/ajmg.b.20173)
- Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J., O'Donovan, M. C. and Thapar, A. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161(1), pp. 133-138. (10.1176/appi.ajp.161.1.133)
- Holmes, J. et al. 2004. The Child Attention-Deficit Hyperactivity Disorder Teacher Telephone Interview (CHATTI): reliability and validity. British Journal of Psychiatry 184(1), pp. 74-78. (10.1192/bjp.184.1.74)
- Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9(2), pp. 169-173. (10.1038/sj.mp.4001387)
- Thapar, A., Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J. and O'Donovan, M. C. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33(6), pp. 721-721.
- Payton, A. et al. 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13(3), pp. 183-185.
- Langley, K. et al. 2003. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics 13(2), pp. 107-110. (10.1097/01.ypg.0000056177.32550.a5)
- Lawson, D. C. et al. 2003. Association analysis of monoamine oxidase a and attention deficit hyperactivity disorder. American Journal of Medical Genetics 116B(1), pp. 84-89. (10.1002/ajmg.b.10002)
- West, A. et al. 2002. Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios. Molecular Psychiatry 7(9), pp. 962-966. (10.1038/sj.mp.4001129)
- Hawi, Z. et al. 2002. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Molecular Psychiatry 7(7), pp. 718-725. (10.1038/sj.mp.4001048)
Book sections
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention-deficit hyperactivity disorder. In: Stanford, S. C. and Sciberras, E. eds. Current Topics in Behavioral Neurosciences. Berlin, Heidelberg: Springer, pp. 1-26., (10.1007/7854_2022_338)
Books
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention deficit hyperactivity disorder. Springer Nature.
Thesis
- Langley, K. 2005. A genetic study of attention deficit hyperactivity disorder: examining environmental influences and phenotypic variation.. PhD Thesis, Cardiff University.
Ymchwil
Pynciau ymchwil a phapurau cysylltiedig
Gan ddefnyddio samplau clinigol o blant ag Anhwylder Gorfywiogrwydd Diffyg Canolbwyntio (ADHD) a phroblemau iechyd meddwl eraill (e.e. anhwylder ymddygiad, Anhwylderau Sbectrwm Awtistiaeth) a samplau epidemiolegol, mae gennyf ddiddordeb mewn sut mae ffactorau risg genetig ac amgylcheddol yn dylanwadu ar gyflwyniad anhwylderau a phroblemau cyd-forbid.
Mae gen i ddiddordeb hefyd yn ystod datblygiad ADHD a sut mae cyflwyniad yn newid gydag oedran, effaith unigol a chymdeithasol problemau parhaus yn ogystal â'r ffactorau risg sy'n gysylltiedig â pharhad neu dderbyniad symptomau.
Cydweithredwyr ymchwil
Canolfan MRC ar gyfer Geneteg a Genomeg Niwroseiciatrig
Y Ganolfan Genedlaethol ar gyfer Iechyd Meddwl (NCMH)
Grŵp Seiciatreg Plant a'r Glasoed, Sefydliad Meddygaeth Seicolegol a Niwrowyddorau Clinigol, Ysgol Meddygaeth, Prifysgol Caerdydd
Bywgraffiad
Addysg israddedig
2000: BA (Anrh.) Seicoleg, Prifysgol Durham (2:1)
Addysg ôl-raddedig
2005: PhD, Prifysgol Caerdydd
Teitl traethawd ymchwil: "Astudiaeth enetig o ADHD: Archwilio dylanwadau amgylcheddol ac amrywiad ffenoteipig"
2016: Tystysgrif Ôl-raddedig mewn Dysgu ac Addysgu – Rhagoriaeth 2015-2016, Prifysgol Caerdydd, UK
Cyflogaeth
Yn dilyn fy ngradd israddedig ym Mhrifysgol Durham, dechreuais weithio fel Seicolegydd Ymchwil (2001-2003) gyda'r Athro Anita Thapar yng Ngholeg Meddygaeth Prifysgol Cymru (Ysgol Meddygaeth Prifysgol Caerdydd bellach) ar brosiect a ariennir gan Ymddiriedolaeth Wellcome sy'n ymchwilio i genynnau tueddiad ar gyfer Anhwylder Gorfywiogrwydd Diffyg Sylw (ADHD). Taniodd y prosiect fy niddordeb mewn iechyd meddwl a deall y ffactorau risg genetig ac amgylcheddol sy'n gysylltiedig ag anhwylderau o'r fath.
Arweiniodd hyn at gychwyn ar PhD, dan oruchwyliaeth yr Athro Thapar a'r Athro Peter Holmans, gan ymchwilio i sut mae ffactorau risg genetig ac amgylcheddol ar gyfer ADHD yn dylanwadu ar gyflwyniad clinigol yr anhwylder a'r rhyngweithio rhwng y ffactorau hyn. Estynnwyd fy ngwaith drwy Wobr Cymrodoriaeth VIP Ymddiriedolaeth Wellcome (2005-2006).
Tra'n parhau i weithio ym maes ffactorau genetig a ffactorau risg eraill ar gyfer ADHD a phroblemau iechyd meddwl eraill plentyndod, yn ystod fy swydd ôl-ddoethurol yn yr Ysgol Meddygaeth (2006-2011), Prifysgol Caerdydd , ymddiddolais mewn defnyddio dyluniadau arbrofol naturiol i ymchwilio i lwybrau achosol rhwng ffactorau risg genetig, gwybyddol a chymdeithasol a phroblemau ymddygiad plentyndod.
Ar ôl gweithio gyda'r Athro Nick Craddock fel rhan o'r tîm sy'n sefydlu'r Ganolfan Genedlaethol ar gyfer Iechyd Meddwl (NCMH), y Ganolfan Ymchwil Biofeddygol gyntaf yng Nghymru (2012-2013), dechreuais swydd darlithydd yn yr Ysgol Seicoleg, Prifysgol Caerdydd, ym mis Awst 2013 a chefais fy nyrchafu i Uwch Lecutrer yn 2017.
Anrhydeddau a dyfarniadau
Gwobrau/pwyllgorau allanol
- 2018-2020: Aelod o Grŵp Llywio Niwroddatblygiadol T4CHYP Llywodraeth Cymru
- 2015-cyfredol: Golygydd cyswllt, Seiciatreg BMC
- 2010-cyfredol: Aelod o'r Bwrdd Cynghori, Journal of Child Psychology & Psychiatry
- 2009-cyfredol: Aelod o Ganolfan MRC ar gyfer Geneteg Neroseiciatrig a Genomeg
- 2005-2006: Cymrodoriaeth VIP Ymddiriedolaeth Wellcome, Prifysgol Caerdydd
Aelod o Gymdeithas Seicolegol Prydain; Aelod o weithgor ADHD o Gonsortiwm Geneteg Seiciatrig Rhyngwladol; Rhwydwaith ADHD Ewropeaidd Eunethydis
Aelodaethau proffesiynol
Aelodaeth Proffesiynol
- Cymdeithas Seicolegol Prydain;
- Gweithgor ADHD o Gonsortiwm Geneteg Seiciatrig Rhyngwladol;
- Rhwydwaith ADHD Ewropeaidd Eunethydis
Meysydd goruchwyliaeth
Diddordebau ymchwil ôl-raddedig
Os oes gennych ddiddordeb mewn gwneud cais am PhD, neu am ragor o wybodaeth am fy ymchwil, cysylltwch â mi'n uniongyrchol (manylion cyswllt ar gael ar y dudalen 'Trosolwg'), neu gyflwyno cais ffurfiol.
Myfyrwyr presennol
- Silvia Colonna 2016-2020 (cyflwynwyd), Teitl traethawd ymchwil: Pwysigrwydd hunanreolaeth emosiynol mewn ADHD plentyndod parhaus
- Rebecca Ellis 2018-2021, Teitl traethawd ymchwil: Cyd-gynhyrchu ymyriad i wella gofal i blant ag Anhwylderau ar y Sbectrwm Awtistiaeth: Astudiaeth aml-ddulliau trawsddisgyblaethol ar draws disgyblaethau. Cyd-oruchwyliwr gyda'r Athro Sharon Williams (Prifysgol Abertawe) a Lisa Hurt (Ysgol Meddygaeth)
- Thomas Broughton 2019-2022, Teitl traethawd Ymchwil: Profi rôl oedran cymharol o fewn ier ysgol ar iechyd meddwl mewn plant â bregusrwydd niwroddatblygiadol. Cyd-oruchwyliwr gyda'r Athro Stephan Collishaw (Ysgol Meddygaeth) a'r Athro Kate Tilling (Prifysgol Bryste)
- Lorna Ushaw 2019-2023, Teitl traethawd ymchwil: Optimeiddio canlyniadau iechyd meddwl oedolion mewn plant â phroblemau niwroddatblygiadol: Rhyngweithio ffactorau cymdeithasol a genetig. Cyd-oruchwyliwr gyda'r Athro Stephan Collishaw (Ysgol Meddygaeth), yr Athro Jon Heron (Prifysgol Bryste) a Dr Gemma Hammerton (Prifysgol Bryste)
Cyn-fyfyrwyr
- Sharifah Shameem Syed Salim Agha: Dyfarnwyd 2017, teitl traethawd ymchwil: Archwilio rôl seicopatholeg rhieni mewn sampl o blant ag ADHD: Ymchwilio i ddylanwadau ar phenoteip plant ac amgylchedd y teulu
- Charlotte Fry: Dyfarnwyd 2018, Thesis title: Swyddogaethau Gweithredol, creadigrwydd ac iechyd meddwl mewn pobl ifanc ddigartref: goblygiadau ar gyfer canlyniadau tai. Cyd-oruchwyliwr gyda'r Athro Katherine Shelton
- Zoe Williams: Dyfarnwyd 2018, Thesis Title: Y gorgyffwrdd rhwng anhwylder diffyg sylw/gorfywiogrwydd a symptomau Anhwylder Sbectrwm Awtistiaeth a'u cysylltiad â sgiliau darllen a gallu gwybyddiaeth gymdeithasol.
