![Mariah Lelos](https://profiles-cardiff.imgix.net/attachments/1099?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Mariah Lelos
(hi/ei)
Darllenydd
Ysgol y Biowyddorau
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Rwy'n cyd-gyfarwyddo'r Grŵp Atgyweirio Ymennydd (BRG), lle rydym yn canolbwyntio ar ddeall a thrin clefydau niwroddirywiol, yn enwedig clefyd Parkinson a Huntington. Mae gennym ddiddordeb mewn deall amlygiad diffygion echddygol a di-fodur (gwybyddol, niwroseiciatreg) mewn clefydau dirywiol gan ddefnyddio briwiau, fector firaol a modelau cnofilod a addaswyd yn enetig. Rydym hefyd yn ymchwilio i allu celloedd newydd (hESC- a hiPSC-deillio) a therapïau genynnau i leddfu'r namau hyn a gwneud y gorau o'r triniaethau hyn i'w cymhwyso yn glinigol.
Fi yw Dirprwy Bennaeth yr Is-adran Niwrowyddoniaeth
Rwy'n PI yn y Sefydliad Darganfod Meddyginiaethau (MDI) ac yn gyd-fyfyriwr yn y Sefydliad Ymchwil Dementia (DRI).
Rwy'n gweithredu fel Arweinydd Thema Cyswllt ar gyfer Meddwl, Brain a Niwrowyddorau
Fi yw'r Dirprwy Gadeirydd a Chynrychiolydd Biosi ar y Panel Lles Anifeiliaid ac Ymchwil (AWARP)
Rwyf hefyd yn aelod o bwyllgor GMBA
Rwy'n gweithredu fel Arholwr Allanol yng Ngholeg Kings Llundain ar gyfer y BSc Niwrowyddoniaeth a Seicoleg
Cyhoeddiad
2024
- Clark, B. J., Lelos, M. J. and Loring, J. F. 2024. Advancing Parkinson’s disease treatment: cell replacement therapy with neurons derived from pluripotent stem cells. Stem Cells 42(9), pp. 781-790., article number: sxae042. (10.1093/stmcls/sxae042)
- Hennegan, J. et al. 2024. Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development. iScience 27(1), article number: 108670. (10.1016/j.isci.2023.108670)
2023
- Lelos, M. J., Murphy, E. M., Lindgren, H. S., Dunnett, S. B. and Lane, E. L. 2023. Impaired cognitive and motor function are coincident with l -DOPA-induced dyskinesia in a model of Parkinson’s disease. Scientific Reports 13, article number: 17697. (10.1038/s41598-023-44869-y)
- Indrigo, M. et al. 2023. Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2. EMBO Molecular Medicine 15(11), article number: e15984. (10.15252/emmm.202215984)
- Casella, C. et al. 2023. Differences in white matter detected by ex vivo 9.4T MRI are associated with axonal changes in the R6/1 model of Huntington’s Disease. [Online]. BioRXiv: BioRXiv. (10.1101/2023.10.02.560424) Available at: https://doi.org/10.1101/2023.10.02.560424
- Clinch, S. P., Busse, M., Griffiths, J., Rosser, A. and Lelos, M. 2023. Identification of the neural correlates underlying conflict resolution performance using a rodent analogue of the Stroop tests. Neuroscience 524, pp. 79-88. (10.1016/j.neuroscience.2023.05.024)
- Rees, D. et al. 2023. Acyl-ghrelin attenuates neurochemical and motor deficits in the 6-OHDA model of Parkinson’s Disease. Cellular and Molecular Neurobiology 43, pp. 2377-2384. (10.1007/s10571-022-01282-9)
- Hills, R. et al. 2023. Neurite outgrowth and gene expression profile correlate with efficacity of human induced pluripotent stem cell-derived dopamine neuron grafts. Stem Cells and Development 32(13-14), pp. 387-397. (10.1089/scd.2023.0043)
2022
- Jareno, P. G., Bartley, O., Precious, S., Rosser, A. and Lelos, M. 2022. Challenges in progressing cell therapies to the clinic for Huntington's disease: A review of the progress made with pluripotent stem cell derived medium spiny neurons. In: Lane, E. L., Drew, C. and Lelos, M. J. eds. International Review of Neurobiology: Current Challenges in Cell Therapy for Neurodegenerative Diseases., Vol. 166. Elsevier, pp. 1-48., (10.1016/bs.irn.2022.09.003)
- Lelos, M. J. 2022. Investigating cell therapies in animal models of Parkinson's and Huntington's disease: current challenges and considerations. In: Lane, E. L., Drew, C. and Lelos, M. J. eds. International Review of Neurobiology., Vol. 166. Elsevier, pp. 158-189., (10.1016/bs.irn.2022.09.005)
- Lane, E. L. and Lelos, M. J. 2022. Defining the unknowns for cell therapies in Parkinson's disease. Disease Models and Mechanisms 15(10), article number: dmm049543. (10.1242/dmm.049543)
- Sap, J. B. I. et al. 2022. [18F]Difluorocarbene for Positron Emission Tomography. Nature 606, pp. 102-108. (10.1038/s41586-022-04669-2)
- Lelos, M. J. 2022. Can cell and gene therapies improve cognitive symptoms in Parkinson's disease?. Journal of Integrative Neuroscience 21(3), article number: 78. (10.31083/j.jin2103078)
- Lane, E. L., Harrison, D. J., Ramos-Varas, E., Hills, R., Turner, S. and Lelos, M. J. 2022. Spontaneous graft-induced dyskinesias are independent of 5-HT neurons and levodopa priming in a model of Parkinson's disease. Movement Disorders 37(3), pp. 613-619. (10.1002/mds.28856)
2021
- Bartley, O. J. M., Lelos, M. J., Gray, W. P. and Rosser, A. E. 2021. Do foetal transplant studies continue to be justified in Huntington's disease?. Neuronal Signaling 5, article number: acerbic. (10.1042/NS20210019)
2020
- Lelos, M. 2020. Overview of Alzheimer's and Parkinson's diseases and the role of protein aggregation in these neurodegenerative diseases. In: Salgado, A. J. ed. Handbook of Innovations in Central Nervous System Regenerative Medicine. Elsevier, pp. 29-53., (doi.org/10.1016/B978-0-12-818084-6.00002-7)
2018
- Lelos, M. J. and Dunnett, S. B. 2018. Generating excitotoxic lesion models of Huntington’s Disease. In: Precious, S. V., Rosser, A. E. and Dunnett, S. B. eds. Huntington’s Disease. Methods in Molecular Biology New York, NY, USA:, pp. 209-220., (10.1007/978-1-4939-7825-0_11)
- Clinch, S. P., Busse, M., Lelos, M. J. and Rosser, A. E. 2018. Rethinking functional outcome measures: the development of an upper limb test to assess basal ganglia dysfunction. Frontiers in Neuroscience 12, article number: 366. (10.3389/fnins.2018.00366)
2017
- Kirkeby, A. et al. 2017. Predictive markers guide differentiation to improve graft outcome in clinical translation of hESC-based therapy for Parkinson's disease. Cell Stem Cell 20(1), pp. 135-148. (10.1016/j.stem.2016.09.004)
2016
- Yhnell, E., Lelos, M. J., Dunnett, S. B. and Brooks, S. P. 2016. L30 Cognitive training improves disease symptoms in a mouse model of huntington's disease. Journal of Neurology, Neurosurgery & Psychiatry 87(Supp 1), pp. A100-A101. (10.1136/jnnp-2016-314597.285)
- Yhnell, E., Lelos, M. J., Dunnett, S. B. and Brooks, S. P. 2016. Cognitive training modifies disease symptoms in a mouse model of Huntington's disease. Experimental Neurology 282, pp. 19-26. (10.1016/j.expneurol.2016.05.008)
- Harvey, A. K. et al. 2016. Novel application of behavioral assays allows dissociation of joint pathology from systemic extra-articular alterations induced by inflammatory arthritis. Journal of Rheumatic Diseases and Treatment 2(2), article number: 33. (10.23937/2469-5726/1510033)
- Lelos, M., Morgan, R. J., Kelly, C., Torres, E. M., Rosser, A. E. and Dunnett, S. B. 2016. Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinson's disease. Experimental Neurology 278, pp. 54-61. (10.1016/j.expneurol.2016.02.003)
- Lelos, M. J. et al. 2016. Direct comparison of rat- and human-derived ganglionic eminence tissue grafts on motor function. Cell Transplantation 25, pp. 665-675. (10.3727/096368915X690297)
2014
- Lelos, M. J. and Good, M. A. 2014. β-Amyloid pathology alters neural network activation during retrieval of contextual fear memories in a mouse model of Alzheimer's disease. European Journal of Neuroscience 39(10), pp. 1690-1703. (10.1111/ejn.12527)
2013
- Murphy, E. M., Lelos, M. J., O'Neill, M. J., Lane, E. L. and Dunnett, S. B. 2013. Long-term restorative effects of bromocriptine on operant responding in the 6-hydroxydopamine-lesioned rat. NeuroReport 24(18), pp. 1019-1024. (10.1097/WNR.0000000000000060)
- Heuer, A., Lelos, M. J., Kelly, C., Torres, E. M. and Dunnett, S. B. 2013. Dopamine-rich grafts alleviate deficits in contralateral response space induced by extensive dopamine depletion in rats. Experimental Neurology 247, pp. 485-495. (10.1016/j.expneurol.2013.01.020)
- Lelos, M. J., Lane, E. and Dunnett, S. B. 2013. What helps can also hinder: A dissociation in the acute effect of levodopa treatment on motor and cognitive functions. Movement Disorders 28(5), pp. 563-564. (10.1002/mds.25294)
- Carri, A. D. et al. 2013. Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32(+) medium-sized spiny neurons. Development 140(2), pp. 301-312. (10.1242/dev.084608)
- Lelos, M. J., Harrison, D. J., Rosser, A. E. and Dunnett, S. B. 2013. The lateral neostriatum is necessary for compensatory ingestive behaviour after intravascular dehydration in female rats. Appetite 71, pp. 287-294. (10.1016/j.appet.2013.09.003)
- Trueman, R. C., Klein, A., Lindgren, H. S., Lelos, M. J. and Dunnett, S. B. 2013. Repair of the CNS using endogenous and transplanted neural stem cells. Current Topics in Behavioural Neurosciences 15, pp. 357-398. (10.1007/7854_2012_223)
2012
- Lelos, M. J., Harrison, D. J. and Dunnett, S. B. 2012. Intrastriatal excitotoxic lesion or dopamine depletion of the neostriatum differentially impairs response execution in extrapersonal space. European Journal of Neuroscience 36(10), pp. 3420-3428. (10.1111/j.1460-9568.2012.08256.x)
- Lindgren, H. S., Lelos, M. J. and Dunnett, S. B. 2012. Do alpha-synuclein vector injections provide a better model of Parkinson's disease than the classic 6-hydroxydopamine model?. Experimental Neurology 237(1), pp. 36-42. (10.1016/j.expneurol.2012.05.022)
- Lelos, M. J. and Good, M. A. 2012. c-Fos expression reveals aberrant neural network activity during cued fear conditioning in APPswe transgenic mice. Neurobiology of Learning and Memory 98(1), pp. 1-11. (10.1016/j.nlm.2012.03.001)
- Dunnett, S. B., Heuer, A., Lelos, M. J., Brooks, S. P. and Rosser, A. E. 2012. Bilateral striatal lesions disrupt performance in an operant delayed reinforcement task in rats. Brain Research Bulletin 88(2-3), pp. 251-260. (10.1016/j.brainresbull.2011.04.002)
- Heuer, A., Smith, G. A., Lelos, M. J., Lane, E. L. and Dunnett, S. B. 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites. Behavioural Brain Research 228(1), pp. 30-43. (10.1016/j.bbr.2011.11.027)
- Lelos, M. J., Dowd, E. and Dunnett, S. B. 2012. Nigral grafts in animal models of Parkinson's disease. Is recovery beyond motor function possible?. In: Progress in Brain Research., Vol. 200. Elsevier, pp. 113-142., (10.1016/B978-0-444-59575-1.00006-5)
2011
- Lelos, M. J., Harrison, D. J. and Dunnett, S. B. 2011. Impaired sensitivity to Pavlovian stimulus-outcome learning after excitotoxic lesion of the ventrolateral neostriatum. Behavioural Brain Research 225(2), pp. 522-528. (10.1016/j.bbr.2011.08.017)
- Thomas, R. S., Lelos, M. J., Good, M. A. and Kidd, E. J. 2011. Clathrin-mediated endocytic proteins are upregulated in the cortex of the Tg2576 mouse model of Alzheimer's disease-like amyloid pathology. Biochemical and Biophysical Research Communications 415(4), pp. 656-661. (10.1016/j.bbrc.2011.10.131)
- Lelos, M. J., Thomas, R. S., Kidd, E. J. and Good, M. A. 2011. Outcome-specific satiety reveals a deficit in context-outcome, but not stimulus-or action-outcome, associations in aged Tg2576 mice. Behavioral Neuroscience 125(3), pp. 412-425. (10.1037/a0023415)
- Lelos, M. J. and Dunnett, S. B. 2011. Aberrant dopamine transmission and cognitive dysfunction in animal models of Parkinson's disease. Journal of Parkinson's Disease 1(2), pp. 151-165.
2010
- Lelos, M. J. 2010. Influence of beta-amyloid pathology on emotional learning and memory in the APPswe model of Alzheimer's disease. PhD Thesis, Cardiff University.
- Dunnett, S. B. and Lelos, M. 2010. Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson’s disease. In: Progress in Brain Research., Vol. 184. Elsevier, pp. 35-51., (10.1016/S0079-6123(10)84003-8)
Adrannau llyfrau
- Jareno, P. G., Bartley, O., Precious, S., Rosser, A. and Lelos, M. 2022. Challenges in progressing cell therapies to the clinic for Huntington's disease: A review of the progress made with pluripotent stem cell derived medium spiny neurons. In: Lane, E. L., Drew, C. and Lelos, M. J. eds. International Review of Neurobiology: Current Challenges in Cell Therapy for Neurodegenerative Diseases., Vol. 166. Elsevier, pp. 1-48., (10.1016/bs.irn.2022.09.003)
- Lelos, M. J. 2022. Investigating cell therapies in animal models of Parkinson's and Huntington's disease: current challenges and considerations. In: Lane, E. L., Drew, C. and Lelos, M. J. eds. International Review of Neurobiology., Vol. 166. Elsevier, pp. 158-189., (10.1016/bs.irn.2022.09.005)
- Lelos, M. 2020. Overview of Alzheimer's and Parkinson's diseases and the role of protein aggregation in these neurodegenerative diseases. In: Salgado, A. J. ed. Handbook of Innovations in Central Nervous System Regenerative Medicine. Elsevier, pp. 29-53., (doi.org/10.1016/B978-0-12-818084-6.00002-7)
- Lelos, M. J. and Dunnett, S. B. 2018. Generating excitotoxic lesion models of Huntington’s Disease. In: Precious, S. V., Rosser, A. E. and Dunnett, S. B. eds. Huntington’s Disease. Methods in Molecular Biology New York, NY, USA:, pp. 209-220., (10.1007/978-1-4939-7825-0_11)
- Lelos, M. J., Dowd, E. and Dunnett, S. B. 2012. Nigral grafts in animal models of Parkinson's disease. Is recovery beyond motor function possible?. In: Progress in Brain Research., Vol. 200. Elsevier, pp. 113-142., (10.1016/B978-0-444-59575-1.00006-5)
- Dunnett, S. B. and Lelos, M. 2010. Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson’s disease. In: Progress in Brain Research., Vol. 184. Elsevier, pp. 35-51., (10.1016/S0079-6123(10)84003-8)
Erthyglau
- Clark, B. J., Lelos, M. J. and Loring, J. F. 2024. Advancing Parkinson’s disease treatment: cell replacement therapy with neurons derived from pluripotent stem cells. Stem Cells 42(9), pp. 781-790., article number: sxae042. (10.1093/stmcls/sxae042)
- Hennegan, J. et al. 2024. Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development. iScience 27(1), article number: 108670. (10.1016/j.isci.2023.108670)
- Lelos, M. J., Murphy, E. M., Lindgren, H. S., Dunnett, S. B. and Lane, E. L. 2023. Impaired cognitive and motor function are coincident with l -DOPA-induced dyskinesia in a model of Parkinson’s disease. Scientific Reports 13, article number: 17697. (10.1038/s41598-023-44869-y)
- Indrigo, M. et al. 2023. Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2. EMBO Molecular Medicine 15(11), article number: e15984. (10.15252/emmm.202215984)
- Clinch, S. P., Busse, M., Griffiths, J., Rosser, A. and Lelos, M. 2023. Identification of the neural correlates underlying conflict resolution performance using a rodent analogue of the Stroop tests. Neuroscience 524, pp. 79-88. (10.1016/j.neuroscience.2023.05.024)
- Rees, D. et al. 2023. Acyl-ghrelin attenuates neurochemical and motor deficits in the 6-OHDA model of Parkinson’s Disease. Cellular and Molecular Neurobiology 43, pp. 2377-2384. (10.1007/s10571-022-01282-9)
- Hills, R. et al. 2023. Neurite outgrowth and gene expression profile correlate with efficacity of human induced pluripotent stem cell-derived dopamine neuron grafts. Stem Cells and Development 32(13-14), pp. 387-397. (10.1089/scd.2023.0043)
- Lane, E. L. and Lelos, M. J. 2022. Defining the unknowns for cell therapies in Parkinson's disease. Disease Models and Mechanisms 15(10), article number: dmm049543. (10.1242/dmm.049543)
- Sap, J. B. I. et al. 2022. [18F]Difluorocarbene for Positron Emission Tomography. Nature 606, pp. 102-108. (10.1038/s41586-022-04669-2)
- Lelos, M. J. 2022. Can cell and gene therapies improve cognitive symptoms in Parkinson's disease?. Journal of Integrative Neuroscience 21(3), article number: 78. (10.31083/j.jin2103078)
- Lane, E. L., Harrison, D. J., Ramos-Varas, E., Hills, R., Turner, S. and Lelos, M. J. 2022. Spontaneous graft-induced dyskinesias are independent of 5-HT neurons and levodopa priming in a model of Parkinson's disease. Movement Disorders 37(3), pp. 613-619. (10.1002/mds.28856)
- Bartley, O. J. M., Lelos, M. J., Gray, W. P. and Rosser, A. E. 2021. Do foetal transplant studies continue to be justified in Huntington's disease?. Neuronal Signaling 5, article number: acerbic. (10.1042/NS20210019)
- Clinch, S. P., Busse, M., Lelos, M. J. and Rosser, A. E. 2018. Rethinking functional outcome measures: the development of an upper limb test to assess basal ganglia dysfunction. Frontiers in Neuroscience 12, article number: 366. (10.3389/fnins.2018.00366)
- Kirkeby, A. et al. 2017. Predictive markers guide differentiation to improve graft outcome in clinical translation of hESC-based therapy for Parkinson's disease. Cell Stem Cell 20(1), pp. 135-148. (10.1016/j.stem.2016.09.004)
- Yhnell, E., Lelos, M. J., Dunnett, S. B. and Brooks, S. P. 2016. L30 Cognitive training improves disease symptoms in a mouse model of huntington's disease. Journal of Neurology, Neurosurgery & Psychiatry 87(Supp 1), pp. A100-A101. (10.1136/jnnp-2016-314597.285)
- Yhnell, E., Lelos, M. J., Dunnett, S. B. and Brooks, S. P. 2016. Cognitive training modifies disease symptoms in a mouse model of Huntington's disease. Experimental Neurology 282, pp. 19-26. (10.1016/j.expneurol.2016.05.008)
- Harvey, A. K. et al. 2016. Novel application of behavioral assays allows dissociation of joint pathology from systemic extra-articular alterations induced by inflammatory arthritis. Journal of Rheumatic Diseases and Treatment 2(2), article number: 33. (10.23937/2469-5726/1510033)
- Lelos, M., Morgan, R. J., Kelly, C., Torres, E. M., Rosser, A. E. and Dunnett, S. B. 2016. Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinson's disease. Experimental Neurology 278, pp. 54-61. (10.1016/j.expneurol.2016.02.003)
- Lelos, M. J. et al. 2016. Direct comparison of rat- and human-derived ganglionic eminence tissue grafts on motor function. Cell Transplantation 25, pp. 665-675. (10.3727/096368915X690297)
- Lelos, M. J. and Good, M. A. 2014. β-Amyloid pathology alters neural network activation during retrieval of contextual fear memories in a mouse model of Alzheimer's disease. European Journal of Neuroscience 39(10), pp. 1690-1703. (10.1111/ejn.12527)
- Murphy, E. M., Lelos, M. J., O'Neill, M. J., Lane, E. L. and Dunnett, S. B. 2013. Long-term restorative effects of bromocriptine on operant responding in the 6-hydroxydopamine-lesioned rat. NeuroReport 24(18), pp. 1019-1024. (10.1097/WNR.0000000000000060)
- Heuer, A., Lelos, M. J., Kelly, C., Torres, E. M. and Dunnett, S. B. 2013. Dopamine-rich grafts alleviate deficits in contralateral response space induced by extensive dopamine depletion in rats. Experimental Neurology 247, pp. 485-495. (10.1016/j.expneurol.2013.01.020)
- Lelos, M. J., Lane, E. and Dunnett, S. B. 2013. What helps can also hinder: A dissociation in the acute effect of levodopa treatment on motor and cognitive functions. Movement Disorders 28(5), pp. 563-564. (10.1002/mds.25294)
- Carri, A. D. et al. 2013. Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32(+) medium-sized spiny neurons. Development 140(2), pp. 301-312. (10.1242/dev.084608)
- Lelos, M. J., Harrison, D. J., Rosser, A. E. and Dunnett, S. B. 2013. The lateral neostriatum is necessary for compensatory ingestive behaviour after intravascular dehydration in female rats. Appetite 71, pp. 287-294. (10.1016/j.appet.2013.09.003)
- Trueman, R. C., Klein, A., Lindgren, H. S., Lelos, M. J. and Dunnett, S. B. 2013. Repair of the CNS using endogenous and transplanted neural stem cells. Current Topics in Behavioural Neurosciences 15, pp. 357-398. (10.1007/7854_2012_223)
- Lelos, M. J., Harrison, D. J. and Dunnett, S. B. 2012. Intrastriatal excitotoxic lesion or dopamine depletion of the neostriatum differentially impairs response execution in extrapersonal space. European Journal of Neuroscience 36(10), pp. 3420-3428. (10.1111/j.1460-9568.2012.08256.x)
- Lindgren, H. S., Lelos, M. J. and Dunnett, S. B. 2012. Do alpha-synuclein vector injections provide a better model of Parkinson's disease than the classic 6-hydroxydopamine model?. Experimental Neurology 237(1), pp. 36-42. (10.1016/j.expneurol.2012.05.022)
- Lelos, M. J. and Good, M. A. 2012. c-Fos expression reveals aberrant neural network activity during cued fear conditioning in APPswe transgenic mice. Neurobiology of Learning and Memory 98(1), pp. 1-11. (10.1016/j.nlm.2012.03.001)
- Dunnett, S. B., Heuer, A., Lelos, M. J., Brooks, S. P. and Rosser, A. E. 2012. Bilateral striatal lesions disrupt performance in an operant delayed reinforcement task in rats. Brain Research Bulletin 88(2-3), pp. 251-260. (10.1016/j.brainresbull.2011.04.002)
- Heuer, A., Smith, G. A., Lelos, M. J., Lane, E. L. and Dunnett, S. B. 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites. Behavioural Brain Research 228(1), pp. 30-43. (10.1016/j.bbr.2011.11.027)
- Lelos, M. J., Harrison, D. J. and Dunnett, S. B. 2011. Impaired sensitivity to Pavlovian stimulus-outcome learning after excitotoxic lesion of the ventrolateral neostriatum. Behavioural Brain Research 225(2), pp. 522-528. (10.1016/j.bbr.2011.08.017)
- Thomas, R. S., Lelos, M. J., Good, M. A. and Kidd, E. J. 2011. Clathrin-mediated endocytic proteins are upregulated in the cortex of the Tg2576 mouse model of Alzheimer's disease-like amyloid pathology. Biochemical and Biophysical Research Communications 415(4), pp. 656-661. (10.1016/j.bbrc.2011.10.131)
- Lelos, M. J., Thomas, R. S., Kidd, E. J. and Good, M. A. 2011. Outcome-specific satiety reveals a deficit in context-outcome, but not stimulus-or action-outcome, associations in aged Tg2576 mice. Behavioral Neuroscience 125(3), pp. 412-425. (10.1037/a0023415)
- Lelos, M. J. and Dunnett, S. B. 2011. Aberrant dopamine transmission and cognitive dysfunction in animal models of Parkinson's disease. Journal of Parkinson's Disease 1(2), pp. 151-165.
Gosodiad
- Lelos, M. J. 2010. Influence of beta-amyloid pathology on emotional learning and memory in the APPswe model of Alzheimer's disease. PhD Thesis, Cardiff University.
Gwefannau
- Casella, C. et al. 2023. Differences in white matter detected by ex vivo 9.4T MRI are associated with axonal changes in the R6/1 model of Huntington’s Disease. [Online]. BioRXiv: BioRXiv. (10.1101/2023.10.02.560424) Available at: https://doi.org/10.1101/2023.10.02.560424
Ymchwil
My lab focuses on understanding and treating neurodegenerative diseases, particularly Parkinson’s and Huntington’s diseases. We are interested in understanding the manifestation of motor and non-motor (cognitive, neuropsychiatric) dysfunctions in degenerative diseases using lesion, viral vector and genetically modified rodent models. We are also investigating the ability of novel cell (hESC- and hiPSC-derived) and gene therapies to alleviate these impairments and optimising these treatments for clinical application.
Some current research questions that are being addressed include:
Can hPSC-derived dopamine grafts alleviate non-motor dysfunctions in Parkinson's disease?
Is Pax6 a useful biomarker of transplant maturation and efficacy?
Does neuroinflammation play a role in hPSC-derived dopmine graft-induced dyskinesias?
What is the impact of dopamine production from AAV vectors on striatal-dependent cognitive function?
Can we modulate gene expression to improve neurite outgrowth and synapse formation from hPSC-derived dopamine grafts?
Can hPSC-derived medium spiny neuron transplants form synaptic connections and alleviate non-motor dysfunctions in models of Huntingtons' disease?
Addysgu
Ar hyn o bryd fi yw'r Arweinydd Asesu ac yn ddarlithydd ar y modiwl 3edd flwyddyn 'Niwrobioleg Anhwylderau Ymennydd'.
Rwy'n addysgu ar y modiwl Bioleg Cellog a Moleciwlaidd ar lefel Meistr.
Rwy'n rhedeg wythnos ymarferol i ddysgu profion histolegol ac imiwnocemegol a sgiliau microsgopeg gan ddefnyddio meinweoedd ymennydd cnofilod.
Rwy'n diwtor personol ar gyfer myfyrwyr israddedig Niwrowyddoniaeth a Biofeddygol.
Gweler sgwrs ddiweddar ar fy maes:
- Lelos, M.J. (2022, Ionawr 31). Therapi amnewid celloedd ar gyfer clefydau niwroddirywiol [ffeil fideo]. Yn The Biomedical & Life Sciences Collection, mae Henry Stewart yn trafod. Retrieved Mawrth 22, 2022, o https://hstalks.com/bs/4882/.
Bywgraffiad
My PhD (2005-2010, Prof M Good) investigated neural network dysfunction using mathematical modelling in a mouse model of Alzheimer's disease, with a particular focus on amyloid-induced amydala and hippocampal dysfunction.
My post-doctoral research (2010-2015, Prof S Dunnett) aimed to understand basal ganglia dysfunction in Parkinson's and Huntington's disease and to explore the use of human fetal and novel stem cell derived therapies to alleviate the behavioural impairments.
I was then awarded a Senior Research Fellowship from Parkinson's UK (2015-2018) to investigate the ability of human stem cell derived cell therapy products to ameliorate cognitive impairments in rodent models of Parkinson's disease.
I have recently commenced a Senior Lectureship in the neuroscience department and my lab is exploring several new avenues. We are seeking to understand the mechanisms of neural dysfunction using novel DREADDs manipulations, undertaking PET/MR imaging and using newly created models of disease. We are also studying the impact of novel cell therapy approaches and newly optimised gene therapies on cellular and behavioural function.
Meysydd goruchwyliaeth
Rwy'n awyddus i groesawu myfyrwyr PhD newydd i'r tîm sydd â diddordeb penodol yn:
Clefyd Parkinson
Clefyd Huntington
Diffygion gwybyddol neu niwroseiciatrig
Therapïau celloedd
Therapïau genynnau
Goruchwyliaeth gyfredol
Feras Sharouf
Myfyriwr ymchwil
Jiayu Hao
Myfyriwr ymchwil
Rachel Hills
Myfyriwr ymchwil
Demi Owen-Bowyer
Myfyriwr ymchwil
Prosiectau'r gorffennol
Myfyrwyr PhD blaenorol:
Dr. Ellen Murphy: Effeithiau triniaeth dopaminergig acíwt a chronig ar swyddogaeth echddygol a di-fodur yn y llygoden fawr hemi-Parkinsonaidd
Dr. Susanne Clinch: Datblygu a gwerthuso tasgau ymddygiadol i asesu swyddogaeth ganglia sylfaenol
Cân Dr. Mengru: A yw levodopa yn effeithio ar oroesi niwronau dopaminergig mewndarddol ac ecsogenous?
Dr. Charlotte Bridge: Ymchwilio i rôl dopamin mewn namau gwybyddol mewn model llygod mawr o glefyd Parkinson
Dr. Patricia Garcia Jareno: Ymchwilio i integreiddio gweithredol impiadau sy'n deillio o hESC yng nghlwy'r Huntington
Dr. Feras Sharouf: Optimeiddio darpariaeth a goroesiad therapïau celloedd mewn clefyd Huntington
Dr. Rachel Spicer (Sellick gynt): Dadansoddiad o ryngweithio genetig a phrotein sy'n gysylltiedig â dirywiad a achosir gan helfeydd mutant
Myfyrwyr MPhil blaenorol:
Rachel Hills (MPhil): Nodweddu a chymharu cynhyrchion therapi celloedd sy'n deillio o gleifion mewn model clefyd Parkinson cyn-glinigol
Myfyrwyr Meistr blaenorol:
Ammar Alsulaimi: Effaith Proxison, gwrthocsidydd newydd wedi'i dargedu gan mitochondrial, ar oroesiad niwronau dopamin wedi'u trawsblannu mewn model llygod mawr o glefyd Parkinson
Daniel Dabbs: Dadansoddiad imiwnohistocemegol o iPSCs sy'n deillio o gleifion ar gyfer trawsblannu mewn clefyd Parkinson
Eldad Eradiri: Ymchwilio i effaith oedran meinwe rhoddwyr a pharatoi ar oroesiad ac effeithiolrwydd trawsblaniadau estryal-ffetws dynol cyn-glinigol
Emily Stonelake: Ymchwilio i effaith impiadau dopaminergic bôn-gelloedd embryonig dynol ar swyddogaeth nad yw'n fodurol mewn model cnofilod o glefyd Parkinson
Gareth Williams: Therapi genynnau ar gyfer clefyd Parkinson: yr effaith ar namau gwybyddol
Issac Mondon: Newidiadau i fater gwyn mewn clefyd Huntington cyn-symptomatig gan ddefnyddio modelau llygod R6/1
Jeremie Costales: Effeithiau Levodopa ar oroesiad bôn-gelloedd embryonig dynol trawsblannu (hESC) impiadau mewn llygod mawr 6-OHDA
Joanne Lachica: Gwerthusiad ymateb dos o fector firaol newydd sy'n gysylltiedig ag adeno ar gyfer amnewid dopamin mewn model 6-hydroxydopamin o glefyd Parkinson
Laura Clark: Characterising FoxP1 mynegiant yn y modelau llygoden R6/1 a Q150 HD dros amser
Olivia Edwards: Rwy'nmmunohistochemical dadansoddiad o niwroglia mewn llygod mawr Parkinsonaidd wedi'u trawsblannu â chell dopamin dynol
Phoebe Norton: Mae Xav yn nodi'r fan a'r lle: asesu'r defnydd o ataliad Wnt mewn therapi celloedd ar gyfer clefyd Huntington
Demi Owen-Bowyer: Sefydlu biofarcwyr a throthwyon diogelwch ar gyfer gordyfiant niwral a tumorigenesis mewn niwronau troellog canolig sy'n deillio o fôn-gelloedd embryonig dynol
Contact Details
+44 29208 75541
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
Themâu ymchwil
Arbenigeddau
- Clefyd Parkinson
- Clefyd Huntington
- Therapïau celloedd
- Therapïau genynnau
- Gwybyddiaeth
