Yr Athro Tom Margrain
Senior Lecturer
Yr Ysgol Optometreg a Gwyddorau'r Golwg
- MargrainTH@caerdydd.ac.uk
- +44 29208 76118
- Optometreg a Gwyddorau'r Golwg , Ystafell Ystafell 2.28, Heol Maendy, Heol Maendy, Cathays, Caerdydd, CF24 4HQ
Trosolwyg
Research Interests
My primary research interest is macular disease, the number one cause of visual impairment in the UK. By developing new technologies capable of detecting and monitoring early age-related macular degeneration, I hope we can speed up the development of therapeutic interventions. The techniques developed in our lab are currently being used to obtain proof of concept data in early stage clinical trials. However, whilst $acirc; finding a cure$acirc; for macular disease is my dream, I also recognise that people who already have this condition have to cope with visual impairment and therefore I am also interested in the development of high quality rehabilitation services.

Fig 1. Retinal photograph showing early AMD (A), central visual loss in advanced AMD (B) and diagram showing where AMD starts, the photoreceptor / RPE complex (C).
Teaching Overview
As a clinician I am passionate about clinical teaching quality. I teach our 2nd year undergraduates how to undertake an $acirc; eye examination$acirc; in a module called $acirc; clinical studies and dispensing$acirc; (OP 2101). I also teach $acirc; Optometric Practice$acirc; in the 3rd year and work in our Primary Care Clinics. More recently, I have taken on the role of module leader for the research module in our MSc programme.
Cyhoeddiad
2021
- Eslambolchilar, P., Margrain, T., Htike, H. M. and Lai, Y. 2021. Augmented reality glasses as a mobility aid for people with low vision: a feasibility study of experiences and requirements. Presented at: ACM CHI Conference on Human Factors in Computing Systems, Yokohama, Japan, 8-13 May 2021CHI '21: Proceedings of the 2021 CHI Conference on Human Factors in Computing Systems. ACM pp. 729., (10.1145/3411764.3445327)
2020
- Htike, H. M., Margrain, T. H., Lai, Y. and Eslambolchilar, P. 2020. Ability of head-mounted display technology to improve mobility in people with low vision: a systematic review. Translational Vision Science & Technology 9(10), article number: 26. (10.1167/tvst.9.10.26)
- Margrain, T. H. et al. 2020. Functional imaging of the outer retinal complex using high fidelity imaging retinal densitometry. Scientific Reports 10, article number: 4494. (10.1038/s41598-020-60660-9)
- Callaghan, T., Margrain, T. H. and Binns, A. M. 2020. The effect of systemic hyperoxia and hypoxia on scotopic thresholds in people with early and intermediate age-related macular degeneration. Current Eye Research 45(10), pp. 1273-1282. (10.1080/02713683.2020.1739315)
2019
- Cassels, N. K., Wild, J. M., Margrain, T. H., Blyth, C., Chong, V. and Acton, J. H. 2019. Microperimetry in age-related macular degeneration: an evidence-base for Pattern Deviation probability analysis in microperimetry. Translational Vision Science & Technology 8(6), article number: 48. (10.1167/tvst.8.6.48)
- Dunn, M. J., Harris, C. M., Ennis, F. A., Margrain, T. H., Woodhouse, J. M., McIlreavy, L. and Erichsen, J. T. 2019. An automated segmentation approach to calibrating infantile nystagmus waveforms. Behavior Research Methods 51(5), pp. 2074-2084. (10.3758/s13428-018-1178-5)
- Morny, E. K. A., Patel, K., Votruba, M., Binns, A. and Margrain, T. 2019. The relationship between the photopic negative response and retinal ganglion cell topography. Investigative Ophthalmology & Visual Science 60(6), pp. 1879-1887. (10.1167/iovs.18-25272)
- Nollett, C. et al. 2019. Depressive symptoms in people with a vision impairment: A cross-sectional study to identify who is most at risk. BMJ Open 9(1), article number: e026163. (10.1136/bmjopen-2018-026163)
2018
- Robinson, D. G., Margrain, T. H., Dunn, M. J., Bailey, C. and Binns, A. M. 2018. Low-level night-time light-therapy for age-related macular degeneration: a randomized clinical trial. Investigative Ophthalmology & Visual Science 59(11), pp. 4531-4541. (10.1167/iovs.18-24284)
- Robinson, D. G., Margrain, T. H., Bailey, C. and Binns, A. M. 2018. An evaluation of a battery of functional and structural tests as predictors of likely risk of progression of age-related macular degeneration. Investigative Ophthalmology & Visual Science 60, pp. 580-589. (10.1167/iovs.18-25092)
- Cassels, N., Wild, J., Margrain, T. H., Chong, V. and Acton, J. 2018. The use of microperimetry in assessing visual function in age-related macular degeneration. Survey of Ophthalmology 63(1), pp. 40-55. (10.1016/j.survophthal.2017.05.007)
2017
- Ravenscroft, D., Deng, J., Xie, X., Terry, L., Margrain, T. H., North, R. V. and Wood, A. 2017. AMD classification in choroidal OCT using hierarchical texton mining. Presented at: ACIVS 2017, Antwerp, Belgium, 18-21 Sep 2017 Presented at Blanc-Talon, J. et al. eds.Advanced Concepts for Intelligent Vision Systems, Vol. 10617. Lecture Notes in Artificial Intelligence Cham, Switzerland: Springer pp. 237-248., (10.1007/978-3-319-70353-4_21)
- Dunn, M., Debbie Wiggins, D., Woodhouse, J. M., Margrain, T. H., Harris, C. M. and Erichsen, J. T. 2017. The effect of gaze angle on visual acuity in infantile nystagmus. Investigative Ophthalmology and Visual Science 58(1), pp. 642-650. (10.1167/iovs.16-20370)
2016
- Acton, J. H., Molik, B., Court, H. and Margrain, T. H. 2016. Effect of a home visit-based low vision rehabilitation intervention on visual function outcomes: an exploratory randomized controlled trial. Investigative Ophthalmology & Visual Science 57(15), pp. 6662-6667. (10.1167/iovs.16-19901)
- Terry, L. et al. 2016. Automated Retinal Layer Segmentation Using Spectral Domain Optical Coherence Tomography: Evaluation of Inter-Session Repeatability and Agreement between Devices. Plos One 11(9), article number: e0162001. (10.1371/journal.pone.0162001)
- van der Aa, H., Margrain, T., van Rens, G., Heymans, M. and van Nispen, R. 2016. Psychosocial interventions to improve mental health in adults with vision impairment: systematic review and meta-analysis. Ophthalmic And Physiological Optics 36(5), pp. 584-606. (10.1111/opo.12313)
- Nollett, C. L. et al. 2016. Depression in Visual Impairment Trial (DEPVIT): a randomized clinical trial of depression treatments in people with low vision. Investigative Ophthalmology & Visual Science 57(10), pp. 4247-4254. (10.1167/iovs.16-19345)
- Deng, J., Xie, X., Terry, L., Wood, A., White, N., Margrain, T. H. and North, R. V. 2016. Age-related macular degeneration detection and stage classification using choroidal OCT images. Presented at: ICIAR 2016, Póvoa de Varzim, Portugal, 13-15 Jul 2016 Presented at Campilho, A. and Karray, F. eds.Image Analysis and Recognition: ICIAR 2016, Vol. 9730. Lecture Notes in Computer Science Cham, Switzerland: Springer Verlag pp. 707-715., (10.1007/978-3-319-41501-7_79)
- Acton, J. H., Molik, B., Binns, A., Court, H. J. and Margrain, T. H. 2016. Effect of rehabilitation worker input on visual function outcomes in individuals with low vision: study protocol for a randomised controlled trial. Trials 17, article number: 105. (10.1186/s13063-016-1235-2)
- Nollett, C. et al. 2016. High prevalence of untreated depression in patients accessing low-vision services. Ophthalmology 123(2), pp. 440-441. (10.1016/j.ophtha.2015.07.009)
2015
- Morny, E. K. A., Margrain, T. H., Binns, A. M. and Votruba, M. 2015. Electrophysiological ON and OFF responses in autosomal dominant optic atrophy. Investigative Ophthalmology & Visual Science 56(13), pp. 7629-7637. (10.1167/iovs.15-17951)
- van der Aa, H. P. A., van Rens, G. H. M. B., Comijs, H. C., Margrain, T. H., Gallindo-Garre, F., Twisk, J. W. R. and van Nispen, R. M. A. 2015. Stepped care for depression and anxiety in visually impaired older adults: multicentre randomised controlled trial. BMJ 351, article number: h6127. (10.1136/bmj.h6127)
- Dunn, M., Margrain, T. H., Woodhouse, J. M. and Erichsen, J. T. 2015. Visual processing in infantile nystagmus is not slow. Investigative Ophthalmology & Visual Science 56(9), pp. 5094-5101. (10.1167/iovs.15-16977)
2014
- Dunn, M., Margrain, T. H., Woodhouse, J. M., Ennis, F., Harris, C. M. and Erichsen, J. T. 2014. Author response: grating visual acuity in infantile nystagmus in the absence of image motion. Investigative Ophthalmology and Visual Science 55(8), pp. 4955-4957. (10.1167/iovs.14-15070)
- Gaffney, A. J., Margrain, T. H., Bunce, C. V. and Binns, A. 2014. How effective is eccentric viewing training? A systematic literature review. Ophthalmic and Physiological Optics 34(4), pp. 427-437. (10.1111/opo.12132)
- McKeague, C., Margrain, T., Bailey, C. and Binns, A. 2014. Low-level night-time light therapy for age-related macular degeneration (ALight): study protocol for a randomized controlled trial. Trials 15, article number: 246. (10.1186/1745-6215-15-246)
- Wood, A., Margrain, T. H. and Binns, A. 2014. Detection of Early Age-related macular degeneration using novel functional parameters of the focal cone electroretinogram. PLoS ONE 9(5), article number: e96742. (10.1371/journal.pone.0096742)
- Dunn, M. J., Margrain, T. H., Woodhouse, J. M., Ennis, F. A., Harris, C. M. and Erichsen, J. T. 2014. Grating visual acuity in infantile nystagmus in the absence of image motion. Investigative Ophthalmology & Visual Science 55(4), pp. 2682-2686. (10.1167/iovs.13-13455)
- Gaffney, A. J., Binns, A. and Margrain, T. H. 2014. Measurement of cone dark adaptation: a comparison of four psychophysical methods. Documenta Ophthalmologica 128(1), pp. 33-41. (10.1007/s10633-013-9418-6)
2013
- Jones, P. H., Harris, C. M., Woodhouse, J. M., Margrain, T. H., Ennis, F. and Erichsen, J. T. 2013. Stress and visual function in infantile nystagmus syndrome. Investigative Ophthalmology and Visual Science 54(13), pp. 7943-7951. (10.1167/iovs.13-12560)
- Gaffney, A. J., Binns, A. and Margrain, T. H. 2013. The effect of pre-adapting light intensity on dark adaptation in early age-related macular degeneration. Documenta Ophthalmologica 127(3), pp. 191-199. (10.1007/s10633-013-9400-3)
- van der Aa, H. P. A., van Rens, G. H. M. B., Comijs, H. C., Bosmans, J. E., Margrain, T. H. and van Nispen, R. M. A. 2013. Stepped-care to prevent depression and anxiety in visually impaired older adults - design of a randomised controlled trial. BMC Psychiatry 13, article number: 209. (10.1186/1471-244X-13-209)
2012
- Khadka, J., Ryan, B., Margrain, T. H., Woodhouse, J. M. and Davies, N. 2012. Listening to voices of children with a visual impairment: A focus group study. British Journal of Visual Impairment 30(3), pp. 182-196. (10.1177/0264619612453105)
- Jones, P. H., Wiggins, D., Margrain, T. H., Woodhouse, J. M., Harris, C. M. and Erichsen, J. T. 2012. The impact of stress on visual performance in congenital nystagmus. In: Harris, C. M., Gottlob, I. and Sanders, J. eds. The Challenge of Nystagmus. Nystagmus Network, pp. 239-260.
- Gaffney, A. J., Binns, A. and Margrain, T. H. 2012. Aging and cone dark adaptation. Optometry and Vision Science 89(8), pp. 1219-1224. (10.1097/OPX.0b013e318263c6b1)
- Binns, A. et al. 2012. How effective is low vision service provision? A systematic review. Survey of Ophthalmology 57(1), pp. 34-65. (10.1016/j.survophthal.2011.06.006)
- Margrain, T. H. et al. 2012. The depression in Visual Impairment Trial (DEPVIT): trial design and protocol. BMC Psychiatry 12(1), article number: 57. (10.1186/1471-244X-12-57)
- Margrain, T., Smith, D. and Nollett, C. 2012. Depression and Vision Loss in Ageing. Optometry in Practice 13(2)
2011
- Wood, A., Binns, A., Margrain, T. H., Drexler, W., Povazay, B. W. L., Esmaeelpour Hajyar, M. and Sheen, N. J. L. 2011. Retinal and choroidal thickness in early age-related macular degeneration. American Journal of Ophthalmology 152(6), pp. 1030-1038. (10.1016/j.ajo.2011.05.021)
- Wood, A., Margrain, T. H. and Binns, A. 2011. The effect of bleach duration and age on the ERG photostress test. Graefe's Archive for Clinical and Experimental Ophthalmology 249(9), pp. 1359-1365. (10.1007/s00417-011-1627-7)
- Court, H. J., Ryan, B., Bunce, C. and Margrain, T. H. 2011. How effective is the new community-based Welsh low vision service?. British Journal of Ophthalmology 95(2), pp. 178-184. (10.1136/bjo.2010.179606)
- Gaffney, A. J., Binns, A. and Margrain, T. H. 2011. The repeatability of the Goldmann-Weekers adaptometer for measuring cone adaptation. Documenta Ophthalmologica 122(2), pp. 71-75. (10.1007/s10633-011-9261-6)
- Gaffney, A. J., Binns, A. and Margrain, T. H. 2011. Topography of Cone Dark Adaptation Deficits in Age-Related Maculopathy. Optometry and Vision Science 88(9), pp. 1080-1087. (10.1097/OPX.0b013e3182223697)
- Dickinson, C. et al. 2011. A profile of low vision services in England: the Low Vision Service Model Evaluation (LOVSME) project [Editorial]. Eye 25(7), pp. 829-831. (10.1038/eye.2011.112)
2010
- Khadka, J., Ryan, B., Margrain, T. H., Court, H. J. and Woodhouse, J. M. 2010. Development of the 25-item Cardiff Visual Ability Questionnaire for Children (CVAQC). British Journal of Ophthalmology 94(6), pp. 730-735. (10.1136/bjo.2009.171181)
- Kolarik, A. J., Margrain, T. H. and Freeman, T. C. A. 2010. Precision and accuracy of ocular following: influence of age and type of eye movement. Experimental Brain Research 201(2), pp. 271-282. (10.1007/s00221-009-2036-6)
- O'Connor, E., Margrain, T. H. and Freeman, T. C. A. 2010. Age, eye movement and motion discrimination. Vision Research 50(23), pp. 2588-2599. (10.1016/j.visres.2010.08.015)
- Ryan, B. and Margrain, T. H. 2010. Research findings no 28: All Wales visual impairment database. Project Report. London, UK: Thomas Pocklington Trust.
- Ryan, B., Margrain, T. H., Reidy, A. and Minassian, D. 2010. Occasional paper no 24: All Wales visual impairment database. Project Report. London, UK: Thomas Pocklington Trust.
- Ryan, B., White, S. D., Wild, J. M., Court, H. and Margrain, T. H. 2010. The newly established primary care based Welsh Low Vision Service is effective and has improved access to low vision services in Wales. Ophthalmic And Physiological Optics 30(4), pp. 358-364. (10.1111/j.1475-1313.2010.00729.x)
- Court, H., Greenland, K. and Margrain, T. H. 2010. Measuring patient anxiety in primary care: Rasch analysis of the 6-item Spielberger State Anxiety Scale. Value In Health 13(6), pp. 813-819. (10.1111/j.1524-4733.2010.00758.x)
- Ryan, B. and Margrain, T. H. 2010. Registration for people with sight impairment: Fit for purpose?. British Journal of Ophthalmology 94(12), pp. 1692-1693. (10.1136/bjo.2009.178558)
2009
- Court, H., Greenland, K. and Margrain, T. H. 2009. Predicting state anxiety in optometric practice. Optometry and Vision Science 86(11), pp. 1295-1302. (10.1097/OPX.0b013e3181bb4212)
- Carson, D., Margrain, T. H. and Patel, A. 2009. Reply: Lipofuscin phototoxicity: Reality or myth? [Letter]. Journal of Cataract & Refractive Surgery 35(8), pp. 1479-1480. (10.1016/j.jcrs.2009.03.032)
- Carson, D., Margrain, T. H. and Patel, A. 2009. Reply: Refractive error and age-related lipofuscin accumulation-mediated retinal phototoxicity. Journal of Cataract & Refractive Surgery 35(7), pp. 1321-1322. (10.1016/j.jcrs.2009.02.021)
- Court, H. J., Greenland, K. and Margrain, T. H. 2009. Evaluating the association between anxiety and satisfaction. Optometry and Vision Science 86(3), pp. 216-221. (10.1097/OPX.0b013e318196cf59)
- Carson, D., Margrain, T. H. and Patel, A. 2009. Reply: Retinal phototoxicity in the aging pseudophakic and phakic eye [Letter]. Journal of Cataract & Refractive Surgery 35(2), pp. 210-211. (10.1016/j.jcrs.2008.11.017)
- Tumlinson, A. R., Hermann, B., Hofer, B., Povazay, B., Margrain, T. H., Binns, A. and Drexler, W. 2009. Techniques for extraction of depth-resolved in vivo human retinal intrinsic optical signals with optical coherence tomography. Japanese Journal of Ophthalmology 53(4), pp. 315-326. (10.1007/s10384-009-0684-5)
2008
- Carson, D., Margrain, T. h. and Patel, A. 2008. New approach to evaluate retinal protection by intraocular lenses against age-related lipofuscin accumulation-mediated retinal phototoxicity. Journal of Cataract & Refractive Surgery 34(10), pp. 1785-1792. (10.1016/j.jcrs.2008.06.034)
- Court, H., Greenland, K. and Margrain, T. H. 2008. Evaluating patient anxiety levels during contact lens fitting. Optometry and Vision Science 85(7), pp. 574-580. (10.1097/OPX.0b013e31817dad7a)
- Ryan, B., Court, H. J. and Margrain, T. H. 2008. Measuring low vision service outcomes: Rasch Analysis of the seven-item National Eye Institute visual function questionnaire. Optometry and Vision Science 85(2), pp. 112-121. (10.1097/OPX.0b013e31816225dc)
- Khadka, J., Woodhouse, J. M., Margrain, T. H., Ryan, B. and Davies, N. 2008. Focusing children in focus groups [Abstract]. Ophthalmic and Physiological Optics 28(1), pp. 99-99. (10.1111/j.1475-1313.2007.00530_11.x)
- Kolarik, A. J., Freeman, T. C. A. and Margrain, T. H. 2008. Age and eye movement [Abstract]. Perception 37(2), pp. 314-314. (10.1068/ava07)
2007
- Court, H., Greenland, K. and Margrain, T. H. 2007. Content development of the optometric patient anxiety scale. Optometry and Vision Science 84(8), pp. 729-744. (10.1097/OPX.0b013e31812f7361)
- Binns, A. and Margrain, T. H. 2007. Evaluating Retinal Function in Age-Related Maculopathy with the ERG Photostress Test. Investigative Ophthalmology and Visual Science 48(6), pp. 2806-2813. (10.1167/iovs.06-0392)
- Wiggins, D., Woodhouse, J. M., Margrain, T. H., Harris, C. M. and Erichsen, J. T. 2007. Infantile nystagmus adapts to visual demand. Investigative Ophthalmology and Visual Science 48(5), pp. 2089-2094. (10.1167/iovs.06-1108)
2006
- Binns, A. and Margrain, T. H. 2006. Development of a technique for recording the focal rod ERG. Ophtalmic and physiological optics 26(1), pp. 71-79. (10.1111/j.1475-1313.2005.00355.x)
2005
- Qin, X., Margrain, T. H., To, C. H., Bromham, N. R. and Guggenheim, J. A. 2005. Anisometropia is independently associated with both spherical and cylindrical ametropia. Investigative Ophthalmology & Visual Science 46(11), pp. 4024-4031. (10.1167/iovs.05-0120)
- Binns, A. and Margrain, T. H. 2005. Evaluation of retinal function using the Dynamic Focal Cone ERG. Ophthalmic and Physiological Optics 25(6), pp. 492-500. (10.1111/j.1475-1313.2005.00338.x)
- Margrain, T. H., Ryan, B. and Wild, J. M. 2005. A revolution in Welsh low vision service provision. British Journal of Ophthalmology 89(8), pp. 933-934. (10.1136/bjo.2005.066142)
2004
- Margrain, T. H., Boulton, M. E., Marshall, J. and Sliney, D. H. 2004. Do blue light filters confer protection against age-related macular degeneration?. Progress in Retinal and Eye Research 23(5), pp. 523-531. (10.1016/j.preteyeres.2004.05.001)
- Margrain, T. H., Court, H. and Greenland, K. 2004. Content development of the optometric patient anxiety scale. Progress in Retinal and Eye Research 23(5), pp. 523-531.
2003
- Margrain, T. H., Greenland, K. and Anderson, J. 2003. Evaluating anxiety in patients attending optometric practice. Ophthalmic and Physiological Optics 23(4), pp. 287-293. (10.1046/j.1475-1313.2003.00118.x)
2002
- Margrain, T. H. and Thomson, D. 2002. Sources of variability in the clinical photostress test. Ophthalmic and Physiological Optics 22(1), pp. 61-67. (10.1046/j.1475-1313.2002.00005.x)
- Freeman, T. C. A., Naji, J. J. and Margrain, T. H. 2002. Head-centred motion perception in the ageing visual system. Spatial Vision 15(2), pp. 117-127. (10.1163/15685680252875110)
2000
- Margrain, T. H. 2000. Helping blind and partially sighted people to read: the effectiveness of low vision aids [Letter]. British Journal of Ophthalmology 84(8), pp. 919-921. (10.1136/bjo.84.8.919)
1999
- Margrain, T. H. 1999. Minimising the impact of visual impairment: Low vision aids are a simple way of alleviating impairment [Editorial]. BMJ 318(7197), pp. 1504.
1997
- Margrain, T. H. and Thomson, W. D. 1997. Recovery of spatial vision during dark adaptation in normal subjects. Ophthalmic and Physiological Optics 17(6), pp. 509-515. (10.1046/j.1475-1313.1997.97000331.x)
- Owen, C. G., Margrain, T. H. and Woodward, E. G. 1997. Use of contact lenses by firefighters: Part 2. Clinical evaluation. Ophthalmic and Physiological Optics 17(3), pp. 205-215. (10.1111/j.1475-1313.1997.opo_021.x)
- Owen, C. G., Margrain, T. H. and Woodward, E. G. 1997. Use of contact lenses by firefighters. Part 1: Questionnaire data. Ophthalmic and Physiological Optics 17(2), pp. 102-111. (10.1046/j.1475-1313.1997.96000592.x)
1996
- Margrain, T. H. and Owen, C. 1996. The misting characteristics of spectacle lenses. Ophthalmic and Physiological Optics 16(2), pp. 108-114. (10.1046/j.1475-1313.1996.95000232.x)
- Margrain, T. H., Owen, C. G. and Woodward, E. G. 1996. Prevalence of spectacle and contact lens wear in the UK fire service. Ophthalmic and Physiological Optics 16(1), pp. 11-18. (10.1046/j.1475-1313.1996.95000089.x)
- Margrain, T. H., Birch, J. and Owen, C. G. 1996. Colour vision requirements of firefighters. Occupational Medicine 46(2), pp. 114-124. (10.1093/occmed/46.2.114)
1995
- Owen, C. G., Margrain, T. H. and Woodward, E. G. 1995. Aetiology and prevalence of eye injuries within the United Kingdom fire service. Eye 9(6S), pp. 54-58.
1994
- Margrain, T. H. and Birch, J. 1994. A suitable study to evaluate colour vision requirements for firefighters?. Occupational Medicine 44(5), pp. 257-258. (10.1093/occmed/44.5.257)
Articles
- Htike, H. M., Margrain, T. H., Lai, Y. and Eslambolchilar, P. 2020. Ability of head-mounted display technology to improve mobility in people with low vision: a systematic review. Translational Vision Science & Technology 9(10), article number: 26. (10.1167/tvst.9.10.26)
- Margrain, T. H. et al. 2020. Functional imaging of the outer retinal complex using high fidelity imaging retinal densitometry. Scientific Reports 10, article number: 4494. (10.1038/s41598-020-60660-9)
- Callaghan, T., Margrain, T. H. and Binns, A. M. 2020. The effect of systemic hyperoxia and hypoxia on scotopic thresholds in people with early and intermediate age-related macular degeneration. Current Eye Research 45(10), pp. 1273-1282. (10.1080/02713683.2020.1739315)
- Cassels, N. K., Wild, J. M., Margrain, T. H., Blyth, C., Chong, V. and Acton, J. H. 2019. Microperimetry in age-related macular degeneration: an evidence-base for Pattern Deviation probability analysis in microperimetry. Translational Vision Science & Technology 8(6), article number: 48. (10.1167/tvst.8.6.48)
- Dunn, M. J., Harris, C. M., Ennis, F. A., Margrain, T. H., Woodhouse, J. M., McIlreavy, L. and Erichsen, J. T. 2019. An automated segmentation approach to calibrating infantile nystagmus waveforms. Behavior Research Methods 51(5), pp. 2074-2084. (10.3758/s13428-018-1178-5)
- Morny, E. K. A., Patel, K., Votruba, M., Binns, A. and Margrain, T. 2019. The relationship between the photopic negative response and retinal ganglion cell topography. Investigative Ophthalmology & Visual Science 60(6), pp. 1879-1887. (10.1167/iovs.18-25272)
- Nollett, C. et al. 2019. Depressive symptoms in people with a vision impairment: A cross-sectional study to identify who is most at risk. BMJ Open 9(1), article number: e026163. (10.1136/bmjopen-2018-026163)
- Robinson, D. G., Margrain, T. H., Dunn, M. J., Bailey, C. and Binns, A. M. 2018. Low-level night-time light-therapy for age-related macular degeneration: a randomized clinical trial. Investigative Ophthalmology & Visual Science 59(11), pp. 4531-4541. (10.1167/iovs.18-24284)
- Robinson, D. G., Margrain, T. H., Bailey, C. and Binns, A. M. 2018. An evaluation of a battery of functional and structural tests as predictors of likely risk of progression of age-related macular degeneration. Investigative Ophthalmology & Visual Science 60, pp. 580-589. (10.1167/iovs.18-25092)
- Cassels, N., Wild, J., Margrain, T. H., Chong, V. and Acton, J. 2018. The use of microperimetry in assessing visual function in age-related macular degeneration. Survey of Ophthalmology 63(1), pp. 40-55. (10.1016/j.survophthal.2017.05.007)
- Dunn, M., Debbie Wiggins, D., Woodhouse, J. M., Margrain, T. H., Harris, C. M. and Erichsen, J. T. 2017. The effect of gaze angle on visual acuity in infantile nystagmus. Investigative Ophthalmology and Visual Science 58(1), pp. 642-650. (10.1167/iovs.16-20370)
- Acton, J. H., Molik, B., Court, H. and Margrain, T. H. 2016. Effect of a home visit-based low vision rehabilitation intervention on visual function outcomes: an exploratory randomized controlled trial. Investigative Ophthalmology & Visual Science 57(15), pp. 6662-6667. (10.1167/iovs.16-19901)
- Terry, L. et al. 2016. Automated Retinal Layer Segmentation Using Spectral Domain Optical Coherence Tomography: Evaluation of Inter-Session Repeatability and Agreement between Devices. Plos One 11(9), article number: e0162001. (10.1371/journal.pone.0162001)
- van der Aa, H., Margrain, T., van Rens, G., Heymans, M. and van Nispen, R. 2016. Psychosocial interventions to improve mental health in adults with vision impairment: systematic review and meta-analysis. Ophthalmic And Physiological Optics 36(5), pp. 584-606. (10.1111/opo.12313)
- Nollett, C. L. et al. 2016. Depression in Visual Impairment Trial (DEPVIT): a randomized clinical trial of depression treatments in people with low vision. Investigative Ophthalmology & Visual Science 57(10), pp. 4247-4254. (10.1167/iovs.16-19345)
- Acton, J. H., Molik, B., Binns, A., Court, H. J. and Margrain, T. H. 2016. Effect of rehabilitation worker input on visual function outcomes in individuals with low vision: study protocol for a randomised controlled trial. Trials 17, article number: 105. (10.1186/s13063-016-1235-2)
- Nollett, C. et al. 2016. High prevalence of untreated depression in patients accessing low-vision services. Ophthalmology 123(2), pp. 440-441. (10.1016/j.ophtha.2015.07.009)
- Morny, E. K. A., Margrain, T. H., Binns, A. M. and Votruba, M. 2015. Electrophysiological ON and OFF responses in autosomal dominant optic atrophy. Investigative Ophthalmology & Visual Science 56(13), pp. 7629-7637. (10.1167/iovs.15-17951)
- van der Aa, H. P. A., van Rens, G. H. M. B., Comijs, H. C., Margrain, T. H., Gallindo-Garre, F., Twisk, J. W. R. and van Nispen, R. M. A. 2015. Stepped care for depression and anxiety in visually impaired older adults: multicentre randomised controlled trial. BMJ 351, article number: h6127. (10.1136/bmj.h6127)
- Dunn, M., Margrain, T. H., Woodhouse, J. M. and Erichsen, J. T. 2015. Visual processing in infantile nystagmus is not slow. Investigative Ophthalmology & Visual Science 56(9), pp. 5094-5101. (10.1167/iovs.15-16977)
- Dunn, M., Margrain, T. H., Woodhouse, J. M., Ennis, F., Harris, C. M. and Erichsen, J. T. 2014. Author response: grating visual acuity in infantile nystagmus in the absence of image motion. Investigative Ophthalmology and Visual Science 55(8), pp. 4955-4957. (10.1167/iovs.14-15070)
- Gaffney, A. J., Margrain, T. H., Bunce, C. V. and Binns, A. 2014. How effective is eccentric viewing training? A systematic literature review. Ophthalmic and Physiological Optics 34(4), pp. 427-437. (10.1111/opo.12132)
- McKeague, C., Margrain, T., Bailey, C. and Binns, A. 2014. Low-level night-time light therapy for age-related macular degeneration (ALight): study protocol for a randomized controlled trial. Trials 15, article number: 246. (10.1186/1745-6215-15-246)
- Wood, A., Margrain, T. H. and Binns, A. 2014. Detection of Early Age-related macular degeneration using novel functional parameters of the focal cone electroretinogram. PLoS ONE 9(5), article number: e96742. (10.1371/journal.pone.0096742)
- Dunn, M. J., Margrain, T. H., Woodhouse, J. M., Ennis, F. A., Harris, C. M. and Erichsen, J. T. 2014. Grating visual acuity in infantile nystagmus in the absence of image motion. Investigative Ophthalmology & Visual Science 55(4), pp. 2682-2686. (10.1167/iovs.13-13455)
- Gaffney, A. J., Binns, A. and Margrain, T. H. 2014. Measurement of cone dark adaptation: a comparison of four psychophysical methods. Documenta Ophthalmologica 128(1), pp. 33-41. (10.1007/s10633-013-9418-6)
- Jones, P. H., Harris, C. M., Woodhouse, J. M., Margrain, T. H., Ennis, F. and Erichsen, J. T. 2013. Stress and visual function in infantile nystagmus syndrome. Investigative Ophthalmology and Visual Science 54(13), pp. 7943-7951. (10.1167/iovs.13-12560)
- Gaffney, A. J., Binns, A. and Margrain, T. H. 2013. The effect of pre-adapting light intensity on dark adaptation in early age-related macular degeneration. Documenta Ophthalmologica 127(3), pp. 191-199. (10.1007/s10633-013-9400-3)
- van der Aa, H. P. A., van Rens, G. H. M. B., Comijs, H. C., Bosmans, J. E., Margrain, T. H. and van Nispen, R. M. A. 2013. Stepped-care to prevent depression and anxiety in visually impaired older adults - design of a randomised controlled trial. BMC Psychiatry 13, article number: 209. (10.1186/1471-244X-13-209)
- Khadka, J., Ryan, B., Margrain, T. H., Woodhouse, J. M. and Davies, N. 2012. Listening to voices of children with a visual impairment: A focus group study. British Journal of Visual Impairment 30(3), pp. 182-196. (10.1177/0264619612453105)
- Gaffney, A. J., Binns, A. and Margrain, T. H. 2012. Aging and cone dark adaptation. Optometry and Vision Science 89(8), pp. 1219-1224. (10.1097/OPX.0b013e318263c6b1)
- Binns, A. et al. 2012. How effective is low vision service provision? A systematic review. Survey of Ophthalmology 57(1), pp. 34-65. (10.1016/j.survophthal.2011.06.006)
- Margrain, T. H. et al. 2012. The depression in Visual Impairment Trial (DEPVIT): trial design and protocol. BMC Psychiatry 12(1), article number: 57. (10.1186/1471-244X-12-57)
- Margrain, T., Smith, D. and Nollett, C. 2012. Depression and Vision Loss in Ageing. Optometry in Practice 13(2)
- Wood, A., Binns, A., Margrain, T. H., Drexler, W., Povazay, B. W. L., Esmaeelpour Hajyar, M. and Sheen, N. J. L. 2011. Retinal and choroidal thickness in early age-related macular degeneration. American Journal of Ophthalmology 152(6), pp. 1030-1038. (10.1016/j.ajo.2011.05.021)
- Wood, A., Margrain, T. H. and Binns, A. 2011. The effect of bleach duration and age on the ERG photostress test. Graefe's Archive for Clinical and Experimental Ophthalmology 249(9), pp. 1359-1365. (10.1007/s00417-011-1627-7)
- Court, H. J., Ryan, B., Bunce, C. and Margrain, T. H. 2011. How effective is the new community-based Welsh low vision service?. British Journal of Ophthalmology 95(2), pp. 178-184. (10.1136/bjo.2010.179606)
- Gaffney, A. J., Binns, A. and Margrain, T. H. 2011. The repeatability of the Goldmann-Weekers adaptometer for measuring cone adaptation. Documenta Ophthalmologica 122(2), pp. 71-75. (10.1007/s10633-011-9261-6)
- Gaffney, A. J., Binns, A. and Margrain, T. H. 2011. Topography of Cone Dark Adaptation Deficits in Age-Related Maculopathy. Optometry and Vision Science 88(9), pp. 1080-1087. (10.1097/OPX.0b013e3182223697)
- Dickinson, C. et al. 2011. A profile of low vision services in England: the Low Vision Service Model Evaluation (LOVSME) project [Editorial]. Eye 25(7), pp. 829-831. (10.1038/eye.2011.112)
- Khadka, J., Ryan, B., Margrain, T. H., Court, H. J. and Woodhouse, J. M. 2010. Development of the 25-item Cardiff Visual Ability Questionnaire for Children (CVAQC). British Journal of Ophthalmology 94(6), pp. 730-735. (10.1136/bjo.2009.171181)
- Kolarik, A. J., Margrain, T. H. and Freeman, T. C. A. 2010. Precision and accuracy of ocular following: influence of age and type of eye movement. Experimental Brain Research 201(2), pp. 271-282. (10.1007/s00221-009-2036-6)
- O'Connor, E., Margrain, T. H. and Freeman, T. C. A. 2010. Age, eye movement and motion discrimination. Vision Research 50(23), pp. 2588-2599. (10.1016/j.visres.2010.08.015)
- Ryan, B., White, S. D., Wild, J. M., Court, H. and Margrain, T. H. 2010. The newly established primary care based Welsh Low Vision Service is effective and has improved access to low vision services in Wales. Ophthalmic And Physiological Optics 30(4), pp. 358-364. (10.1111/j.1475-1313.2010.00729.x)
- Court, H., Greenland, K. and Margrain, T. H. 2010. Measuring patient anxiety in primary care: Rasch analysis of the 6-item Spielberger State Anxiety Scale. Value In Health 13(6), pp. 813-819. (10.1111/j.1524-4733.2010.00758.x)
- Ryan, B. and Margrain, T. H. 2010. Registration for people with sight impairment: Fit for purpose?. British Journal of Ophthalmology 94(12), pp. 1692-1693. (10.1136/bjo.2009.178558)
- Court, H., Greenland, K. and Margrain, T. H. 2009. Predicting state anxiety in optometric practice. Optometry and Vision Science 86(11), pp. 1295-1302. (10.1097/OPX.0b013e3181bb4212)
- Carson, D., Margrain, T. H. and Patel, A. 2009. Reply: Lipofuscin phototoxicity: Reality or myth? [Letter]. Journal of Cataract & Refractive Surgery 35(8), pp. 1479-1480. (10.1016/j.jcrs.2009.03.032)
- Carson, D., Margrain, T. H. and Patel, A. 2009. Reply: Refractive error and age-related lipofuscin accumulation-mediated retinal phototoxicity. Journal of Cataract & Refractive Surgery 35(7), pp. 1321-1322. (10.1016/j.jcrs.2009.02.021)
- Court, H. J., Greenland, K. and Margrain, T. H. 2009. Evaluating the association between anxiety and satisfaction. Optometry and Vision Science 86(3), pp. 216-221. (10.1097/OPX.0b013e318196cf59)
- Carson, D., Margrain, T. H. and Patel, A. 2009. Reply: Retinal phototoxicity in the aging pseudophakic and phakic eye [Letter]. Journal of Cataract & Refractive Surgery 35(2), pp. 210-211. (10.1016/j.jcrs.2008.11.017)
- Tumlinson, A. R., Hermann, B., Hofer, B., Povazay, B., Margrain, T. H., Binns, A. and Drexler, W. 2009. Techniques for extraction of depth-resolved in vivo human retinal intrinsic optical signals with optical coherence tomography. Japanese Journal of Ophthalmology 53(4), pp. 315-326. (10.1007/s10384-009-0684-5)
- Carson, D., Margrain, T. h. and Patel, A. 2008. New approach to evaluate retinal protection by intraocular lenses against age-related lipofuscin accumulation-mediated retinal phototoxicity. Journal of Cataract & Refractive Surgery 34(10), pp. 1785-1792. (10.1016/j.jcrs.2008.06.034)
- Court, H., Greenland, K. and Margrain, T. H. 2008. Evaluating patient anxiety levels during contact lens fitting. Optometry and Vision Science 85(7), pp. 574-580. (10.1097/OPX.0b013e31817dad7a)
- Ryan, B., Court, H. J. and Margrain, T. H. 2008. Measuring low vision service outcomes: Rasch Analysis of the seven-item National Eye Institute visual function questionnaire. Optometry and Vision Science 85(2), pp. 112-121. (10.1097/OPX.0b013e31816225dc)
- Khadka, J., Woodhouse, J. M., Margrain, T. H., Ryan, B. and Davies, N. 2008. Focusing children in focus groups [Abstract]. Ophthalmic and Physiological Optics 28(1), pp. 99-99. (10.1111/j.1475-1313.2007.00530_11.x)
- Kolarik, A. J., Freeman, T. C. A. and Margrain, T. H. 2008. Age and eye movement [Abstract]. Perception 37(2), pp. 314-314. (10.1068/ava07)
- Court, H., Greenland, K. and Margrain, T. H. 2007. Content development of the optometric patient anxiety scale. Optometry and Vision Science 84(8), pp. 729-744. (10.1097/OPX.0b013e31812f7361)
- Binns, A. and Margrain, T. H. 2007. Evaluating Retinal Function in Age-Related Maculopathy with the ERG Photostress Test. Investigative Ophthalmology and Visual Science 48(6), pp. 2806-2813. (10.1167/iovs.06-0392)
- Wiggins, D., Woodhouse, J. M., Margrain, T. H., Harris, C. M. and Erichsen, J. T. 2007. Infantile nystagmus adapts to visual demand. Investigative Ophthalmology and Visual Science 48(5), pp. 2089-2094. (10.1167/iovs.06-1108)
- Binns, A. and Margrain, T. H. 2006. Development of a technique for recording the focal rod ERG. Ophtalmic and physiological optics 26(1), pp. 71-79. (10.1111/j.1475-1313.2005.00355.x)
- Qin, X., Margrain, T. H., To, C. H., Bromham, N. R. and Guggenheim, J. A. 2005. Anisometropia is independently associated with both spherical and cylindrical ametropia. Investigative Ophthalmology & Visual Science 46(11), pp. 4024-4031. (10.1167/iovs.05-0120)
- Binns, A. and Margrain, T. H. 2005. Evaluation of retinal function using the Dynamic Focal Cone ERG. Ophthalmic and Physiological Optics 25(6), pp. 492-500. (10.1111/j.1475-1313.2005.00338.x)
- Margrain, T. H., Ryan, B. and Wild, J. M. 2005. A revolution in Welsh low vision service provision. British Journal of Ophthalmology 89(8), pp. 933-934. (10.1136/bjo.2005.066142)
- Margrain, T. H., Boulton, M. E., Marshall, J. and Sliney, D. H. 2004. Do blue light filters confer protection against age-related macular degeneration?. Progress in Retinal and Eye Research 23(5), pp. 523-531. (10.1016/j.preteyeres.2004.05.001)
- Margrain, T. H., Court, H. and Greenland, K. 2004. Content development of the optometric patient anxiety scale. Progress in Retinal and Eye Research 23(5), pp. 523-531.
- Margrain, T. H., Greenland, K. and Anderson, J. 2003. Evaluating anxiety in patients attending optometric practice. Ophthalmic and Physiological Optics 23(4), pp. 287-293. (10.1046/j.1475-1313.2003.00118.x)
- Margrain, T. H. and Thomson, D. 2002. Sources of variability in the clinical photostress test. Ophthalmic and Physiological Optics 22(1), pp. 61-67. (10.1046/j.1475-1313.2002.00005.x)
- Freeman, T. C. A., Naji, J. J. and Margrain, T. H. 2002. Head-centred motion perception in the ageing visual system. Spatial Vision 15(2), pp. 117-127. (10.1163/15685680252875110)
- Margrain, T. H. 2000. Helping blind and partially sighted people to read: the effectiveness of low vision aids [Letter]. British Journal of Ophthalmology 84(8), pp. 919-921. (10.1136/bjo.84.8.919)
- Margrain, T. H. 1999. Minimising the impact of visual impairment: Low vision aids are a simple way of alleviating impairment [Editorial]. BMJ 318(7197), pp. 1504.
- Margrain, T. H. and Thomson, W. D. 1997. Recovery of spatial vision during dark adaptation in normal subjects. Ophthalmic and Physiological Optics 17(6), pp. 509-515. (10.1046/j.1475-1313.1997.97000331.x)
- Owen, C. G., Margrain, T. H. and Woodward, E. G. 1997. Use of contact lenses by firefighters: Part 2. Clinical evaluation. Ophthalmic and Physiological Optics 17(3), pp. 205-215. (10.1111/j.1475-1313.1997.opo_021.x)
- Owen, C. G., Margrain, T. H. and Woodward, E. G. 1997. Use of contact lenses by firefighters. Part 1: Questionnaire data. Ophthalmic and Physiological Optics 17(2), pp. 102-111. (10.1046/j.1475-1313.1997.96000592.x)
- Margrain, T. H. and Owen, C. 1996. The misting characteristics of spectacle lenses. Ophthalmic and Physiological Optics 16(2), pp. 108-114. (10.1046/j.1475-1313.1996.95000232.x)
- Margrain, T. H., Owen, C. G. and Woodward, E. G. 1996. Prevalence of spectacle and contact lens wear in the UK fire service. Ophthalmic and Physiological Optics 16(1), pp. 11-18. (10.1046/j.1475-1313.1996.95000089.x)
- Margrain, T. H., Birch, J. and Owen, C. G. 1996. Colour vision requirements of firefighters. Occupational Medicine 46(2), pp. 114-124. (10.1093/occmed/46.2.114)
- Owen, C. G., Margrain, T. H. and Woodward, E. G. 1995. Aetiology and prevalence of eye injuries within the United Kingdom fire service. Eye 9(6S), pp. 54-58.
- Margrain, T. H. and Birch, J. 1994. A suitable study to evaluate colour vision requirements for firefighters?. Occupational Medicine 44(5), pp. 257-258. (10.1093/occmed/44.5.257)
Book sections
- Jones, P. H., Wiggins, D., Margrain, T. H., Woodhouse, J. M., Harris, C. M. and Erichsen, J. T. 2012. The impact of stress on visual performance in congenital nystagmus. In: Harris, C. M., Gottlob, I. and Sanders, J. eds. The Challenge of Nystagmus. Nystagmus Network, pp. 239-260.
Conferences
- Eslambolchilar, P., Margrain, T., Htike, H. M. and Lai, Y. 2021. Augmented reality glasses as a mobility aid for people with low vision: a feasibility study of experiences and requirements. Presented at: ACM CHI Conference on Human Factors in Computing Systems, Yokohama, Japan, 8-13 May 2021CHI '21: Proceedings of the 2021 CHI Conference on Human Factors in Computing Systems. ACM pp. 729., (10.1145/3411764.3445327)
- Ravenscroft, D., Deng, J., Xie, X., Terry, L., Margrain, T. H., North, R. V. and Wood, A. 2017. AMD classification in choroidal OCT using hierarchical texton mining. Presented at: ACIVS 2017, Antwerp, Belgium, 18-21 Sep 2017 Presented at Blanc-Talon, J. et al. eds.Advanced Concepts for Intelligent Vision Systems, Vol. 10617. Lecture Notes in Artificial Intelligence Cham, Switzerland: Springer pp. 237-248., (10.1007/978-3-319-70353-4_21)
- Deng, J., Xie, X., Terry, L., Wood, A., White, N., Margrain, T. H. and North, R. V. 2016. Age-related macular degeneration detection and stage classification using choroidal OCT images. Presented at: ICIAR 2016, Póvoa de Varzim, Portugal, 13-15 Jul 2016 Presented at Campilho, A. and Karray, F. eds.Image Analysis and Recognition: ICIAR 2016, Vol. 9730. Lecture Notes in Computer Science Cham, Switzerland: Springer Verlag pp. 707-715., (10.1007/978-3-319-41501-7_79)
Monographs
- Ryan, B. and Margrain, T. H. 2010. Research findings no 28: All Wales visual impairment database. Project Report. London, UK: Thomas Pocklington Trust.
- Ryan, B., Margrain, T. H., Reidy, A. and Minassian, D. 2010. Occasional paper no 24: All Wales visual impairment database. Project Report. London, UK: Thomas Pocklington Trust.
Ymchwil
Research Topics and Related Projects:
The primary focus of my research is macular disease. Accounting for 57% of all visual impairment in the UK, macular disease is responsible for significant individual suffering and places a heavy burden on society. My research revolves around two distinct areas of activity. The first is concerned with the development of biomarkers for macular disease that can be used to expedite the evaluation of novel therapeutic interventions. The second relates to the identification of effective rehabilitation interventions that can help people with advanced macular disease cope with vision loss.
Currently, there are no validated biomarkers for the commonest type of macular disease, age-related macular degeneration (AMD). Most clinical trials use the onset of advanced AMD, either neovascular AMD (nAMD) or geographic atrophy (GA), as disease end points. The use of such coarse end points, even for exploratory studies, dictates that trials must be large, long and expensive. To speed up the development of novel treatments for AMD, my research has evaluated the ability of electrophysiological, psychophysical and imaging biomarkers.
For example, by placing sensors around the eye it is possible to measure the tiny voltage produced by the retina known as the electroretinogram (ERG). By measuring the recovery of this signal following exposure of the eye to bright light we developed a sensitive objective test for early AMD called the ERG photostress test (see Fig 1).

Fig 1. Typical ERG photostress recovery data in two people with early AMD. Immediately after exposure to a bright light, that bleaches almost all cone photopigment the ERG is extinguished (upper traces). Over the following 5 minutes the signal, an index of disease status, recovers. The lower plots show how the amplitude of the signal increases over time (From Binns & Margrain. IOVS. 2007).
Results from our lab indicated that $acirc; dark adaptation$acirc; , the recovery of visual function in the dark following a period of light adaptation, is a sensitive candidate biomarker for AMD. Hence we have spent the last few years refining the test protocol i.e. examining the effect of stimulus location, bleach intensity and psychophysical methods on sensitivity and specificity.

Fig 2. Location of various annuli used to optimise dark adaptation parameters (A). The dark adaptation functions obtained from the central most to outermost annuli are shown going from top to bottom (B). (From Gaffney et al, 2011).
Right now we are collaborating with a team from the UK$acirc; s Astronomy Technology Centre to develop an imaging retinal densitometer that can measure the recovery of visual pigments directly. We can now evaluate the regeneration of rod or cone pigments on a point by point basis across the retina.

Fig. 3. The upper row shows a series of false colour retinal images. These are recorded continuously, at 5Hz, both before and immediately after exposure to intense illumination that $acirc; bleaches$acirc; retinal photopigments. The images obtained at each wavelenght are initially used to quantify reflectance, then wavelenght dependent optical density and, via a pigment fitting routine, rod and cone photoreceptor signals. The lower right hand plot shows how the rod and cone signal varies as a function of time at the fovea. (Patent 2012 No. 1206174.3).
Rehabilitation research is my other passion. How can we help people with untreatable visual loss maintain their independence? My involvement in the establishment of the community based Welsh Low Vision Service was a great opportunity to evaluate a range of interventions and survey based outcome measures. The Low Vision Service Model Evaluation (LOVSME) project, supported by the RNIB, was another collaborative project examining the effectiveness of low vision services. And more recently, a group of us have begun to examine the impact of mental health status on rehabilitation outcomes. The Depression in Visual Impairment Trial (DEPVIT), funded by Guide Dogs, is evaluating 3 treatments for depression in a multicentre RCT. We hope the results will help shape future NICE guidance.
Funding:
Acton, Margrain £15,000 $acirc; Evaluation of the Macular Integrity Assessment microperimeter$acirc; . Fight for Sight, 2013-2014
.
Melotte, Margrain, Binns, Henry, £844,000, $acirc; Imaging densitometry$acirc; , National Institute of Health Research i4i Programme, 2013-2016
Margrain & Gaffney, £5,642, $acirc; Net Mobility$acirc; , Guide Dogs, 2013-2015.
Margrain, £10,000, $acirc; Ophthalmology Research in Wales$acirc; , National Institute of Social Care and Health Research (NISCHR), 2012.
Margrain, Binns &Tucker, £52,254, $acirc; Imaging Densitometry$acirc; Cardiff President$acirc; s Studentship Award, 2013-2016.
Binns & Margrain, £52,254, $acirc; Night Lights for AMD: a randomised controlled trial$acirc; , College of Optometrists, 2012-2015.
Binns & Margrain, £52,254 $acirc; Hypoxia in age-related macular degeneration$acirc; , JE Williams Endowment Studentship, 2012-2015.
Binns & Margrain, £17,532, $acirc; Evaluating Eccentric Viewing and Steady Eye Technique Training$acirc; , Macular Disease Society, 2012.
Henry D, Margrain TH, Binns A. £86,600, $acirc; Development of an imaging retinal densitometer$acirc; , National Institute of Health Research (NIHR), 2010-2012.
Margrain TH, Smith DJ, Stanford M, Tudor-Edwards RT, Ryan B, Bunce C, Casten R, Hegel M. £207,000, $acirc; Depression in Visual Impairment Trial (DEPVIT), Guide Dogs, 2011-2014.
Binns AM, Margrain TH. £51,000, $acirc; Early detection of age-related macular degeneration$acirc; . College of Optometrists, 2008-2011.
Margrain TH, Bunce C, Dickinson C, Harper R, Tudor-Edwards R, Binns A, Woodhouse M, Link P, Jackson J, Massof R, Wolffsohn J, Stelmack J. £58, 000, $acirc; Low Vision Service Model Evaluation (LOVSME)$acirc; , Royal National Institute of Blind People, 2008-2009.
Research Groups:
Macular Research Group
Clinical and Investigative Vision Sciences
Current research Associates / Assistants / Managers:
Allannah Gaffney, Research Assistant, $acirc; Net Mobility$acirc; , Guide Dogs, 2013-2015.
Claire Nollett, $acirc; DEPVIT Study Coordinator$acirc; , Guide Dogs, 2011-2014
Julia Shearn, $acirc; DEPVIT Psychological Therapist$acirc; , Guide Dogs, 2012-2014
Ryre Cornish, $acirc; DEPVIT Psychological Therapist$acirc; , Guide Dogs, 2013-2014.
Research Collaborators:
Dr Danny Smith, University of Glasgow, Depression in Visual Impairment Trial.
Dr Catey Bunce, Moorfields Eye Hospital, Evaluating Eccentric Viewing and Steady Eye Technique Training.
Prof. Miles Stanford, St Thomas$acirc; Hospital, Depression in Visual Impairment Trial.
Dr Ruth van Nispen, VU University Medical Center in Amsterdam. Stepped-care program in visual impairment.
Prof. Rhiannon Tudor Edwards, Bangor University, Depression in Visual Impairment Trial.
Dr Robin Casten, Jefferson Medical College, Depression in Visual Impairment Trial.
Dr Mark Hegel, Dartmouth-Hitchcock Medical Centre, Depression in Visual Impairment Trial.
Mr David Henry, UK Astronomy Technology Centre, Edinburgh, Imaging Densitometry.
Prof Chris Dickinson, The University of Manchester, Low Vision Service Model Evaluation.
Dr Robert Harper, Royal Manchester Eye Hospital, Low Vision Service Model Evaluation.
Dr Robert Massof, Wilmer Eye Institute, Low Vision Service Model Evaluation.
Dr Joan Stelmack, Edward Hines Jr VA Hospital, Low Vision Service Model Evaluation.
Mr Stephen Todd, UK Astronomy Technology Centre, Edinburgh, Imaging Densitometry.
Mr Dave Melotte, UK Astronomy Technology Centre, Edinburgh, Imaging Densitometry.
Mr David Atkinson, UK Astronomy Technology Centre, Edinburgh, Imaging Densitometry.
Dr Lorna Marquès-Brocksopp, Guide Dogs, Net Mobility.
Prof Gary Rubin, Institute of Ophthalmology, Depression in Visual Impairment Trial.
Prof Jonathan Jackson, Australian College of Optometry, Depression in Visual Impairment Trial.
Dr Helen Prance, University of Sussex, The Electroretinogram.
Prof Tom Freeman, Cardiff University, Eye movements and ageing.
Bywgraffiad
Educational and Professional Qualifications:
2000 MILT (Member of the Higher Education Academy).
1998 PhD (Visual Science) City University, London.
1987 MCOptom (Member of the College of Optometrists).
1986 BSc (Ophthalmic Optics, 2:1), Aston University.
Academic Positions:
2010-present: Reader / Director of Innovation and Engagement, Cardiff University.
2005-2010: Senior Lecturer / Clinical Director, Cardiff University.
2000-2005: Lecturer (B) / Clinical Director, Cardiff University.
1997-2000: Lecturer (A), Cardiff University.
1995-1996: Research Fellow, City University, London.
1993-1995: Research Assistant, City University, London.
School Roles and Committees:
2012 - present: Director of Innovation and Engagement
2011 - present: Member of Research Committee
2012 - present: Board of Directors
2011 - present: Module Leader, MSc Research Programme
2004 - present: Module Leader, BSc, $acirc; Optometric Practice$acirc;
External Committees:
2010 - present: National Institute for Social Care and Health Research (NISCHR), Wales Specialty Group Lead for Ophthalmology.
2010 - present: National Institute for Health Research (NIHR) Ophthalmology Speciality Group, Welsh Representative.
2011 - present: Trial Advisor: $acirc; Stepped-care to reduce depression and anxiety in visually impaired older adults - a randomized controlled trial.$acirc;
2008 - 2011: External Examiner, Undergraduate Scheme, City University, London.
Innovation and Engagement:
2014: Presentation, Top Doctors Conference, Macular Society, Bristol, $acirc; Experimental treatments for Macular Disease$acirc; .
2012: Presentation, Queens University Belfast $acirc; Early Detection of AMD$acirc; .
2012: Presentation, City University, London $acirc; Macular Disease Detection and Diagnosis$acirc; .
2012: Presentation, Singleton Hospital, Swansea. $acirc; Ophthalmology Research Scoping Study$acirc; .
2011: Presentation Eye Care Conference, Cardiff $acirc; Sight Loss and Depression$acirc;
2011: Presentation South Wales Eye Forum $acirc; Depression in Visual Impairment$acirc;
2011: Resource: RNIB, $acirc; Low Vision Assessment Framework$acirc;
2010: Presentation: Wales and West Vision Conference, $acirc; Low Vision Service Models$acirc;
2010: Presentation: School of Optics and Optometry, Terrassa, Spain, $acirc; Clinical teaching of Optometry$acirc; ,
2010: TV, CANAL TERRASSA, Spain, $acirc; Optometry$acirc; .
Aelodaethau proffesiynol
- 2010-present - National Institute for Social Care and Health Research (NISCHR), Wales Specialty Group Lead for Ophthalmology.
- 2010-present - National Institute for Health Research (NIHR) Ophthalmology Speciality Group, Welsh Representative.
- 2011-present - Trial Advisor: Stepped-care to reduce depression and anxiety in visually impaired older adults - a randomized controlled trial.
- 2008-2011 - External Examiner, Undergraduate Scheme, City University, London.
Safleoedd academaidd blaenorol
- 2010-present - Reader / Director of Innovation and Engagement, Cardiff University.
- 2005-2010 - Senior Lecturer / Clinical Director, Cardiff University.
- 2000-2005 - Lecturer (B) / Clinical Director, Cardiff University.
- 1997-2000 - Lecturer (A), Cardiff University.
- 1995-1996 - Research Fellow, City University, London.
- 1993-1995 - Research Assistant, City University, London.
Pwyllgorau ac adolygu
- 2012-present - Director of Innovation and Engagement
- 2011-present - Member of Research Committee
- 2012-present - Board of Directors
- 2012-present - Module Leader, MSc Research Programme
- 2004-present - Module Leader, BSc, Optometric Practice