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Yr Athro Christopher Marshall
BSc(Hons), MSc, PhD, FIPEM, CSci
Timau a rolau for Christopher Marshall
Cyfarwyddwr Canolfan Ymchwil a Delweddu PET Diagnostig Cymru
Trosolwg
Mae'r Athro Marshall yn Wyddonydd Clinigol cofrestredig yn y wladwriaeth sy'n arbenigo mewn Meddygaeth Niwclear, Cynhyrchu Radiofferyllol, Rheoli Ansawdd a Tomograffeg Allyrru Positron. Ymunodd yr Athro Marshall â PETIC yn 2010 i ymgymryd â swydd Cyfarwyddwr Gweithrediadau ar ôl treulio 6 blynedd fel Pennaeth Radioisotopau yng Ngogledd Iwerddon a chyn hynny bu'n gweithio yn Lincoln ac Aberdeen. Yn 2013, cafodd yr Athro Marshall ei ddyrchafu'n Gyfarwyddwr PETIC yn 2013 ac ers hynny mae wedi cynyddu trwybwn cleifion a gweithgarwch ymchwil yn sylweddol yn y cyfleuster.
Yn 2000, dechreuodd yr Athro Marshall PhD rhan-amser gyda Phrifysgol Aberdeen a chyflwynodd ei draethawd ymchwil yn llwyddiannus ar rôl Delweddu Moleciwlaidd mewn Monitro a Rhagfynegi Ymateb Canser y Fron i Cemotherapi Neoadjuvant yn 2004.
Mae prif gyflawniadau yr Athro Marshall yn cynnwys dylunio, comisiynu a rheoli'r prosiect cyfleusterau meddygaeth niwclear newydd yn Ysbyty Brenhinol Victoria a Chanolfan Ganser Gogledd Iwerddon a'r cyfleusterau cyclotron yn Belfast a Chaerdydd yn ogystal ag arwain ar gyflwyno gwasanaeth PET Cymru gyfan a chynhyrchu sawl radiotraciwr a radiometalau newydd.
Cyhoeddiad
2025
- Paisey, S. J. et al. 2025. Imaging of human stem cell-derived dopamine grafts correlates with behavioural recovery and reveals microstructural brain changes. Neurobiology of Disease 209 106910. (10.1016/j.nbd.2025.106910)
2024
- Smith, R. L. et al. 2024. NEMA NU 2-2018 evaluation and image quality optimization of a new generation digital 32-cm axial field-of-view Omni Legend PET-CT using a genetic evolutionary algorithm. Biomedical Physics & Engineering Express 10 (2) 025032. (10.1088/2057-1976/ad286c)
2023
- Alsyed, E. et al. 2023. A heterogeneous phantom study for investigating the stability of PET images radiomic features with varying reconstruction settings. Frontiers in Nuclear Medicine 3 (10.3389/fnume.2023.1078536)
2022
- Gendron, T. et al., 2022. Multi‐patient dose synthesis of [18F] Flumazenil via a copper‐mediated 18F‐fluorination. EJNMMI Radiopharmacy and Chemistry 7 5. (10.1186/s41181-022-00158-z)
2020
- Fenwick, A. J. et al. 2020. Absolute standardisation and determination of the half-life and gamma emission intensities of 89Zr. Applied Radiation and Isotopes 166 109294. (10.1016/j.apradiso.2020.109294)
- Alsyed, E. et al. 2020. A self organizing map for exploratory analysis of PET radiomic features. Presented at: 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Boston, MA, USA 31 October -7 November 2020. 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE. (10.1109/NSS/MIC42677.2020.9507846)
- Smith, R. L. et al. 2020. Deep learning PET epilepsy detection with a novel symmetric loss convolutional autoencoder. Presented at: 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Boston, MA, USA 31 October - 7 November 2020. 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE(10.1109/NSS/MIC42677.2020.9507980)
- Cavaliere, A. et al. 2020. Radiosynthesis of [18F]-labelled pro-nucleotides (ProTides). Molecules 25 (3) 704. (10.3390/molecules25030704)
2019
- Alsyed, E. et al. 2019. The statistical influence of imaging time and segmentation volume on PET radiomic features: A preclinical study. Presented at: 2019 IEEE NSS-MIC Manchester, UK 26 October - 2 November 2019. Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference. IEEE. , pp.1-4. (10.1109/NSS/MIC42101.2019.9059863)
- Watson, H. A. et al. 2019. L-selectin enhanced T cells improve the efficacy of cancer immunotherapy. Frontiers in Immunology 10 1321. (10.3389/fimmu.2019.01321)
- Whone, A. L. et al., 2019. Extended treatment with glial cell line-derived neurotrophic factor in Parkinson's Disease. Journal of Parkinson's Disease 9 (2), pp.301-313. (10.3233/JPD-191576)
- Foley, K. et al. 2019. Cyclo-oxygenase-2 expression is associated with mean standardised uptake value on 18F-fluorodeoxyglucose positron emission tomography in oesophageal adenocarcinoma. British Journal of Radiology 92 (1099) 20180668. (10.1259/bjr.20180668)
- Parkinson, C. et al. 2019. Machine-learned target volume delineation of 18F-FDG PET images after one cycle of induction chemotherapy. Physica Medica, European Journal of Medical Physics 61 , pp.85-93. (10.1016/j.ejmp.2019.04.020)
- Whone, A. et al., 2019. Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease. Brain 142 (3), pp.512-525. (10.1093/brain/awz023)
- Smith, R. L. et al. 2019. Reinforcement learning for object detection in PET imaging. Presented at: 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Manchester, England 26 October - 02 November 2019. 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE. , pp.1-4. (10.1109/NSS/MIC42101.2019.9060031)
2018
- Parkinson, C. et al. 2018. Dependency of patient risk stratification on PET target volume definition in oesophageal cancer. Presented at: ESTRO Barcelona, Spain 20-24 April 2018.
- Parkinson, C. et al. 2018. ATLAAS - Investigation into the incorporation of morphological data on automated segmentation. Presented at: EANM Congress 2018: European Association of Nuclear Medicine. Dusseldorf, Germany 12-18 October 2018.
- Parkinson, C. et al. 2018. Evaluation of prognostic models developed using standardised image features from different PET automated segmentation methods. EJNMMI Research 8 29. (10.1186/s13550-018-0379-3)
- Parkinson, C. et al. 2018. Target volume delineation of PET post one cycle of induction chemotherapy in oropharyngeal cancer. Radiotherapy and Oncology 127 (S1), pp.S634-S635. EP-1126. (10.1016/S0167-8140(18)31436-1)
- Smith, R. L. et al. 2018. Deep learning pre-clinical medical image segmentation for automated organ-wise delineation of PET. Presented at: Annual Congress of the European Association of Nuclear Medicine Barcelona, Spain 12-16 October 2019. Vol. 45.
2017
- Parkinson, C. et al. 2017. Impact of 18F-Choline PET scan acquisition time on delineation of GTV in prostate cancer [Poster Abstract]. Radiotherapy and Oncology 123 (S1), pp.S714-S715. (10.1016/S0167-8140(17)31768-1)
- Berthon, B. et al., 2017. Head and neck target delineation using a novel PET automatic segmentation algorithm. Radiotherapy and Oncology 122 (2), pp.242-247. (10.1016/j.radonc.2016.12.008)
- Jolles, S. et al. 2017. FDG PET-CT imaging of therapeutic response in granulomatous lymphocytic interstitial lung disease (GLILD) in common variable immunodeficiency (CVID). Clinical & Experimental Immunology 187 (1), pp.138-145. (10.1111/cei.12856)
2016
- Berthon, B. et al., 2016. ATLAAS: an automatic decision tree-based learning algorithm for advanced image segmentation in positron emission tomography. Physics in Medicine and Biology 61 (13), pp.4855-4869. (10.1088/0031-9155/61/13/4855)
2015
- Berthon, B. et al. 2015. PETSTEP: Generation of synthetic PET lesions for fast evaluation of segmentation methods. Physica Medica 31 (8), pp.969-980. (10.1016/j.ejmp.2015.07.139)
- Marshall, C. et al. 2015. Implementation of routine production of [18F]-fallypride on the TRASIS all-in-one universal synthesizer. European Journal of Nuclear Medicine and Molecular Imaging 42 (S1), pp.S479. (10.1007/s00259-015-3198-z)
- Dabkowski, A. M. et al. 2015. Optimization of cyclotron production for radiometal of Zirconium 89. Acta Physica Polonica Series A 127 (5), pp.1479-1482. (10.12693/APhysPolA.127.1479)
- Berthon, B. et al. 2015. A novel phantom technique for evaluating the performance of PET auto-segmentation methods in delineating heterogeneous and irregular lesions. EJNMMI Physics 2 (1) 13. (10.1186/s40658-015-0116-1)
2014
- Marshall, C. et al. 2014. Quantification of the activity of tritium produced during the routine synthesis of 18F fluorodeoxyglucose for positron emission tomography. Journal of Radiological Protection 34 (2), pp.435-444. (10.1088/0952-4746/34/2/435)
2013
- Berthon, B. et al. 2013. Influence of cold walls on PET image quantification and volume segmentation: A phantom study. Medical Physics 40 (8) 082505. (10.1118/1.4813302)
2011
- Ferguson, D. et al., 2011. Measurement of long lived radioactive impurities retained in the disposable cassettes on the Tracerlab MX system during the production of [18F]FDG. Applied Radiation and Isotopes 69 (10), pp.1479-1485. (10.1016/j.apradiso.2011.05.028)
- Ferguson, D. et al., 2011. Investigation of staff finger doses during quality control of FDG production. Health Physics 100 (5), pp.523-529. (10.1097/HP.0b013e3181f1e9b5)
Cynadleddau
- Alsyed, E. et al. 2020. A self organizing map for exploratory analysis of PET radiomic features. Presented at: 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Boston, MA, USA 31 October -7 November 2020. 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE. (10.1109/NSS/MIC42677.2020.9507846)
- Smith, R. L. et al. 2020. Deep learning PET epilepsy detection with a novel symmetric loss convolutional autoencoder. Presented at: 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Boston, MA, USA 31 October - 7 November 2020. 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE(10.1109/NSS/MIC42677.2020.9507980)
- Alsyed, E. et al. 2019. The statistical influence of imaging time and segmentation volume on PET radiomic features: A preclinical study. Presented at: 2019 IEEE NSS-MIC Manchester, UK 26 October - 2 November 2019. Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference. IEEE. , pp.1-4. (10.1109/NSS/MIC42101.2019.9059863)
- Smith, R. L. et al. 2019. Reinforcement learning for object detection in PET imaging. Presented at: 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Manchester, England 26 October - 02 November 2019. 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE. , pp.1-4. (10.1109/NSS/MIC42101.2019.9060031)
- Parkinson, C. et al. 2018. Dependency of patient risk stratification on PET target volume definition in oesophageal cancer. Presented at: ESTRO Barcelona, Spain 20-24 April 2018.
- Parkinson, C. et al. 2018. ATLAAS - Investigation into the incorporation of morphological data on automated segmentation. Presented at: EANM Congress 2018: European Association of Nuclear Medicine. Dusseldorf, Germany 12-18 October 2018.
- Smith, R. L. et al. 2018. Deep learning pre-clinical medical image segmentation for automated organ-wise delineation of PET. Presented at: Annual Congress of the European Association of Nuclear Medicine Barcelona, Spain 12-16 October 2019. Vol. 45.
Erthyglau
- Paisey, S. J. et al. 2025. Imaging of human stem cell-derived dopamine grafts correlates with behavioural recovery and reveals microstructural brain changes. Neurobiology of Disease 209 106910. (10.1016/j.nbd.2025.106910)
- Smith, R. L. et al. 2024. NEMA NU 2-2018 evaluation and image quality optimization of a new generation digital 32-cm axial field-of-view Omni Legend PET-CT using a genetic evolutionary algorithm. Biomedical Physics & Engineering Express 10 (2) 025032. (10.1088/2057-1976/ad286c)
- Alsyed, E. et al. 2023. A heterogeneous phantom study for investigating the stability of PET images radiomic features with varying reconstruction settings. Frontiers in Nuclear Medicine 3 (10.3389/fnume.2023.1078536)
- Gendron, T. et al., 2022. Multi‐patient dose synthesis of [18F] Flumazenil via a copper‐mediated 18F‐fluorination. EJNMMI Radiopharmacy and Chemistry 7 5. (10.1186/s41181-022-00158-z)
- Fenwick, A. J. et al. 2020. Absolute standardisation and determination of the half-life and gamma emission intensities of 89Zr. Applied Radiation and Isotopes 166 109294. (10.1016/j.apradiso.2020.109294)
- Cavaliere, A. et al. 2020. Radiosynthesis of [18F]-labelled pro-nucleotides (ProTides). Molecules 25 (3) 704. (10.3390/molecules25030704)
- Watson, H. A. et al. 2019. L-selectin enhanced T cells improve the efficacy of cancer immunotherapy. Frontiers in Immunology 10 1321. (10.3389/fimmu.2019.01321)
- Whone, A. L. et al., 2019. Extended treatment with glial cell line-derived neurotrophic factor in Parkinson's Disease. Journal of Parkinson's Disease 9 (2), pp.301-313. (10.3233/JPD-191576)
- Foley, K. et al. 2019. Cyclo-oxygenase-2 expression is associated with mean standardised uptake value on 18F-fluorodeoxyglucose positron emission tomography in oesophageal adenocarcinoma. British Journal of Radiology 92 (1099) 20180668. (10.1259/bjr.20180668)
- Parkinson, C. et al. 2019. Machine-learned target volume delineation of 18F-FDG PET images after one cycle of induction chemotherapy. Physica Medica, European Journal of Medical Physics 61 , pp.85-93. (10.1016/j.ejmp.2019.04.020)
- Whone, A. et al., 2019. Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease. Brain 142 (3), pp.512-525. (10.1093/brain/awz023)
- Parkinson, C. et al. 2018. Evaluation of prognostic models developed using standardised image features from different PET automated segmentation methods. EJNMMI Research 8 29. (10.1186/s13550-018-0379-3)
- Parkinson, C. et al. 2018. Target volume delineation of PET post one cycle of induction chemotherapy in oropharyngeal cancer. Radiotherapy and Oncology 127 (S1), pp.S634-S635. EP-1126. (10.1016/S0167-8140(18)31436-1)
- Parkinson, C. et al. 2017. Impact of 18F-Choline PET scan acquisition time on delineation of GTV in prostate cancer [Poster Abstract]. Radiotherapy and Oncology 123 (S1), pp.S714-S715. (10.1016/S0167-8140(17)31768-1)
- Berthon, B. et al., 2017. Head and neck target delineation using a novel PET automatic segmentation algorithm. Radiotherapy and Oncology 122 (2), pp.242-247. (10.1016/j.radonc.2016.12.008)
- Jolles, S. et al. 2017. FDG PET-CT imaging of therapeutic response in granulomatous lymphocytic interstitial lung disease (GLILD) in common variable immunodeficiency (CVID). Clinical & Experimental Immunology 187 (1), pp.138-145. (10.1111/cei.12856)
- Berthon, B. et al., 2016. ATLAAS: an automatic decision tree-based learning algorithm for advanced image segmentation in positron emission tomography. Physics in Medicine and Biology 61 (13), pp.4855-4869. (10.1088/0031-9155/61/13/4855)
- Berthon, B. et al. 2015. PETSTEP: Generation of synthetic PET lesions for fast evaluation of segmentation methods. Physica Medica 31 (8), pp.969-980. (10.1016/j.ejmp.2015.07.139)
- Marshall, C. et al. 2015. Implementation of routine production of [18F]-fallypride on the TRASIS all-in-one universal synthesizer. European Journal of Nuclear Medicine and Molecular Imaging 42 (S1), pp.S479. (10.1007/s00259-015-3198-z)
- Dabkowski, A. M. et al. 2015. Optimization of cyclotron production for radiometal of Zirconium 89. Acta Physica Polonica Series A 127 (5), pp.1479-1482. (10.12693/APhysPolA.127.1479)
- Berthon, B. et al. 2015. A novel phantom technique for evaluating the performance of PET auto-segmentation methods in delineating heterogeneous and irregular lesions. EJNMMI Physics 2 (1) 13. (10.1186/s40658-015-0116-1)
- Marshall, C. et al. 2014. Quantification of the activity of tritium produced during the routine synthesis of 18F fluorodeoxyglucose for positron emission tomography. Journal of Radiological Protection 34 (2), pp.435-444. (10.1088/0952-4746/34/2/435)
- Berthon, B. et al. 2013. Influence of cold walls on PET image quantification and volume segmentation: A phantom study. Medical Physics 40 (8) 082505. (10.1118/1.4813302)
- Ferguson, D. et al., 2011. Measurement of long lived radioactive impurities retained in the disposable cassettes on the Tracerlab MX system during the production of [18F]FDG. Applied Radiation and Isotopes 69 (10), pp.1479-1485. (10.1016/j.apradiso.2011.05.028)
- Ferguson, D. et al., 2011. Investigation of staff finger doses during quality control of FDG production. Health Physics 100 (5), pp.523-529. (10.1097/HP.0b013e3181f1e9b5)
