![Christopher Marshall BSc(Hons), MSc, PhD, FIPEM, CSci](https://profiles-cardiff.imgix.net/attachments/2498?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Christopher Marshall
BSc(Hons), MSc, PhD, FIPEM, CSci
Cyfarwyddwr Canolfan Delweddu Tomograffeg Gollwng Positronau (PET) at ddibenion Ymchwil a Diagnostig
Trosolwyg
Mae'r Athro Marshall yn Wyddonydd Clinigol cofrestredig yn y wladwriaeth sy'n arbenigo mewn Meddygaeth Niwclear, Cynhyrchu Radiofferyllol, Rheoli Ansawdd a Tomograffeg Allyrru Positron. Ymunodd yr Athro Marshall â PETIC yn 2010 i ymgymryd â swydd Cyfarwyddwr Gweithrediadau ar ôl treulio 6 blynedd fel Pennaeth Radioisotopau yng Ngogledd Iwerddon a chyn hynny bu'n gweithio yn Lincoln ac Aberdeen. Yn 2013, cafodd yr Athro Marshall ei ddyrchafu'n Gyfarwyddwr PETIC yn 2013 ac ers hynny mae wedi cynyddu trwybwn cleifion a gweithgarwch ymchwil yn sylweddol yn y cyfleuster.
Yn 2000, dechreuodd yr Athro Marshall PhD rhan-amser gyda Phrifysgol Aberdeen a chyflwynodd ei draethawd ymchwil yn llwyddiannus ar rôl Delweddu Moleciwlaidd mewn Monitro a Rhagfynegi Ymateb Canser y Fron i Cemotherapi Neoadjuvant yn 2004.
Mae prif gyflawniadau yr Athro Marshall yn cynnwys dylunio, comisiynu a rheoli'r prosiect cyfleusterau meddygaeth niwclear newydd yn Ysbyty Brenhinol Victoria a Chanolfan Ganser Gogledd Iwerddon a'r cyfleusterau cyclotron yn Belfast a Chaerdydd yn ogystal ag arwain ar gyflwyno gwasanaeth PET Cymru gyfan a chynhyrchu sawl radiotraciwr a radiometalau newydd.
Cyhoeddiad
2024
- Smith, R. L., Bartley, L., O’Callaghan, C., Haberska, L. and Marshall, C. 2024. NEMA NU 2-2018 evaluation and image quality optimization of a new generation digital 32-cm axial field-of-view Omni Legend PET-CT using a genetic evolutionary algorithm. Biomedical Physics & Engineering Express 10(2), article number: 25032. (10.1088/2057-1976/ad286c)
2023
- Alsyed, E., Smith, R., Bartley, L., Marshall, C. and Spezi, E. 2023. A heterogeneous phantom study for investigating the stability of PET images radiomic features with varying reconstruction settings. Frontiers in Nuclear Medicine 3 (10.3389/fnume.2023.1078536)
2022
- Gendron, T. et al. 2022. Multi‐patient dose synthesis of [18F] Flumazenil via a copper‐mediated 18F‐fluorination. EJNMMI Radiopharmacy and Chemistry 7, article number: 5. (10.1186/s41181-022-00158-z)
2021
- Smith, R. L., Chandler, H., Alsyed, E., Bartley, L., Fielding, P. and Marshall, C. 2021. Deep learning PET epilepsy detection with a novel symmetric loss convolutional autoencoder. Presented at: 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Boston, MA, USA, 31 October -7 November 20202020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE pp. 1-3., (10.1109/NSS/MIC42677.2020.9507980)
- Alsyed, E., Smith, R., Paisey, S., Marshall, C. and Spezi, E. 2021. A self organizing map for exploratory analysis of PET radiomic features. Presented at: 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Boston, MA, USA, 31 October -7 November 20202020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE, (10.1109/NSS/MIC42677.2020.9507846)
2020
- Fenwick, A. J., Collins, S. M., Evans, W. D., Ferreira, K. M., Paisey, S. J., Robinson, A. P. and Marshall, C. 2020. Absolute standardisation and determination of the half-life and gamma emission intensities of 89Zr. Applied Radiation and Isotopes 166, article number: 109294. (10.1016/j.apradiso.2020.109294)
- Cavaliere, A. et al. 2020. Radiosynthesis of [18F]-labelled pro-nucleotides (ProTides). Molecules 25(3), article number: 704. (10.3390/molecules25030704)
2019
- Alsyed, E., Smith, R., Marshall, C., Paisey, S. and Spezi, E. 2019. The statistical influence of imaging time and segmentation volume on PET radiomic features: A preclinical study. Presented at: 2019 IEEE NSS-MIC, 26 October - 2 November 20192019 IEEE NSS-MIC. IEEE
- Watson, H. A. et al. 2019. L-selectin enhanced T cells improve the efficacy of cancer immunotherapy. Frontiers in Immunology 10, article number: 1321. (10.3389/fimmu.2019.01321)
- Whone, A. L. et al. 2019. Extended treatment with glial cell line-derived neurotrophic factor in Parkinson's Disease. Journal of Parkinson's Disease 9(2), pp. 301-313. (10.3233/JPD-191576)
- Foley, K., Christian, A., Peaker, J., Marshall, C., Spezi, E., Kynaston, H. and Roberts, S. A. 2019. Cyclo-oxygenase-2 expression is associated with mean standardised uptake value on 18F-fluorodeoxyglucose positron emission tomography in oesophageal adenocarcinoma. British Journal of Radiology 92(1099), article number: 20180668. (10.1259/bjr.20180668)
- Parkinson, C. et al. 2019. Machine-learned target volume delineation of 18F-FDG PET images after one cycle of induction chemotherapy. Physica Medica, European Journal of Medical Physics 61, pp. 85-93. (10.1016/j.ejmp.2019.04.020)
- Whone, A. et al. 2019. Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease. Brain 142(3), pp. 512-525. (10.1093/brain/awz023)
- Smith, R. L., Ackerley, I. M., Wells, K., Bartley, L., Paisey, S. and Marshall, C. 2019. Reinforcement learning for object detection in PET imaging. Presented at: 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Manchester, England, 26 October - 02 November 20192019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE pp. 1-4., (10.1109/NSS/MIC42101.2019.9060031)
2018
- Parkinson, C. et al. 2018. Dependency of patient risk stratification on PET target volume definition in oesophageal cancer. Presented at: ESTRO, Barcelona, Spain, 20-24 April 2018.
- Parkinson, C., Whybra, P., Staffurth, J., Marshall, C. and Spezi, E. 2018. ATLAAS - Investigation into the incorporation of morphological data on automated segmentation. Presented at: EANM Congress 2018: European Association of Nuclear Medicine., Dusseldorf, Germany, 12-18 October 2018.
- Parkinson, C. et al. 2018. Evaluation of prognostic models developed using standardised image features from different PET automated segmentation methods. EJNMMI Research 8, article number: 29. (10.1186/s13550-018-0379-3)
- Parkinson, C. et al. 2018. Target volume delineation of PET post one cycle of induction chemotherapy in oropharyngeal cancer. Radiotherapy and Oncology 127(S1), pp. S634-S635., article number: EP-1126. (10.1016/S0167-8140(18)31436-1)
- Smith, R. L., Paisey, S. J., Evans, N., Florence, V., Fittock, E., Siebzehnrubl, F. and Marshall, C. 2018. Deep learning pre-clinical medical image segmentation for automated organ-wise delineation of PET. Presented at: Annual Congress of the European Association of Nuclear Medicine, Barcelona, Spain, 12-16 October 2019, Vol. 45.
2017
- Parkinson, C., Chan, J., Syndikus, I., Marshall, C., Staffurth, J. and Spezi, E. 2017. Impact of 18F-Choline PET scan acquisition time on delineation of GTV in prostate cancer [Poster Abstract]. Radiotherapy and Oncology 123(S1), pp. S714-S715. (10.1016/S0167-8140(17)31768-1)
- Berthon, B. et al. 2017. Head and neck target delineation using a novel PET automatic segmentation algorithm. Radiotherapy and Oncology 122(2), pp. 242-247. (10.1016/j.radonc.2016.12.008)
- Jolles, S., Carne, E., Brouns, M., El-Shanawany, T., Williams, P., Marshall, C. and Fielding, P. 2017. FDG PET-CT imaging of therapeutic response in granulomatous lymphocytic interstitial lung disease (GLILD) in common variable immunodeficiency (CVID). Clinical & Experimental Immunology 187(1), pp. 138-145. (10.1111/cei.12856)
2016
- Berthon, B., Marshall, C., Evans, M. and Spezi, E. 2016. ATLAAS: an automatic decision tree-based learning algorithm for advanced image segmentation in positron emission tomography. Physics in Medicine and Biology 61(13), pp. 4855-4869. (10.1088/0031-9155/61/13/4855)
2015
- Berthon, B. et al. 2015. PETSTEP: Generation of synthetic PET lesions for fast evaluation of segmentation methods. Physica Medica 31(8), pp. 969-980. (10.1016/j.ejmp.2015.07.139)
- Marshall, C. et al. 2015. Implementation of routine production of [18F]-fallypride on the TRASIS all-in-one universal synthesizer. European Journal of Nuclear Medicine and Molecular Imaging 42(S1), pp. S479. (10.1007/s00259-015-3198-z)
- Dabkowski, A. M., Paisey, S. J., Talboys, M. and Marshall, C. 2015. Optimization of cyclotron production for radiometal of Zirconium 89. Acta Physica Polonica Series A 127(5), pp. 1479-1482. (10.12693/APhysPolA.127.1479)
- Berthon, B., Marshall, C., Holmes, R. and Spezi, E. 2015. A novel phantom technique for evaluating the performance of PET auto-segmentation methods in delineating heterogeneous and irregular lesions. EJNMMI Physics 2(1), article number: 13. (10.1186/s40658-015-0116-1)
2014
- Marshall, C., Talboys, M., Bukhari, S. and Evans, W. 2014. Quantification of the activity of tritium produced during the routine synthesis of 18F fluorodeoxyglucose for positron emission tomography. Journal of Radiological Protection 34(2), pp. 435-444. (10.1088/0952-4746/34/2/435)
2013
- Berthon, B., Marshall, C., Edwards, A., Evans, M. and Spezi, E. 2013. Influence of cold walls on PET image quantification and volume segmentation: A phantom study. Medical Physics 40(8), article number: 82505. (10.1118/1.4813302)
2011
- Ferguson, D., Orr, P., Gillanders, J., Corrigan, G. and Marshall, C. 2011. Measurement of long lived radioactive impurities retained in the disposable cassettes on the Tracerlab MX system during the production of [18F]FDG. Applied Radiation and Isotopes 69(10), pp. 1479-1485. (10.1016/j.apradiso.2011.05.028)
- Ferguson, D., McGrath, S., O'Hara, G. and Marshall, C. 2011. Investigation of staff finger doses during quality control of FDG production. Health Physics 100(5), pp. 523-529. (10.1097/HP.0b013e3181f1e9b5)
Cynadleddau
- Smith, R. L., Chandler, H., Alsyed, E., Bartley, L., Fielding, P. and Marshall, C. 2021. Deep learning PET epilepsy detection with a novel symmetric loss convolutional autoencoder. Presented at: 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Boston, MA, USA, 31 October -7 November 20202020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE pp. 1-3., (10.1109/NSS/MIC42677.2020.9507980)
- Alsyed, E., Smith, R., Paisey, S., Marshall, C. and Spezi, E. 2021. A self organizing map for exploratory analysis of PET radiomic features. Presented at: 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Boston, MA, USA, 31 October -7 November 20202020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE, (10.1109/NSS/MIC42677.2020.9507846)
- Alsyed, E., Smith, R., Marshall, C., Paisey, S. and Spezi, E. 2019. The statistical influence of imaging time and segmentation volume on PET radiomic features: A preclinical study. Presented at: 2019 IEEE NSS-MIC, 26 October - 2 November 20192019 IEEE NSS-MIC. IEEE
- Smith, R. L., Ackerley, I. M., Wells, K., Bartley, L., Paisey, S. and Marshall, C. 2019. Reinforcement learning for object detection in PET imaging. Presented at: 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Manchester, England, 26 October - 02 November 20192019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE pp. 1-4., (10.1109/NSS/MIC42101.2019.9060031)
- Parkinson, C. et al. 2018. Dependency of patient risk stratification on PET target volume definition in oesophageal cancer. Presented at: ESTRO, Barcelona, Spain, 20-24 April 2018.
- Parkinson, C., Whybra, P., Staffurth, J., Marshall, C. and Spezi, E. 2018. ATLAAS - Investigation into the incorporation of morphological data on automated segmentation. Presented at: EANM Congress 2018: European Association of Nuclear Medicine., Dusseldorf, Germany, 12-18 October 2018.
- Smith, R. L., Paisey, S. J., Evans, N., Florence, V., Fittock, E., Siebzehnrubl, F. and Marshall, C. 2018. Deep learning pre-clinical medical image segmentation for automated organ-wise delineation of PET. Presented at: Annual Congress of the European Association of Nuclear Medicine, Barcelona, Spain, 12-16 October 2019, Vol. 45.
Erthyglau
- Smith, R. L., Bartley, L., O’Callaghan, C., Haberska, L. and Marshall, C. 2024. NEMA NU 2-2018 evaluation and image quality optimization of a new generation digital 32-cm axial field-of-view Omni Legend PET-CT using a genetic evolutionary algorithm. Biomedical Physics & Engineering Express 10(2), article number: 25032. (10.1088/2057-1976/ad286c)
- Alsyed, E., Smith, R., Bartley, L., Marshall, C. and Spezi, E. 2023. A heterogeneous phantom study for investigating the stability of PET images radiomic features with varying reconstruction settings. Frontiers in Nuclear Medicine 3 (10.3389/fnume.2023.1078536)
- Gendron, T. et al. 2022. Multi‐patient dose synthesis of [18F] Flumazenil via a copper‐mediated 18F‐fluorination. EJNMMI Radiopharmacy and Chemistry 7, article number: 5. (10.1186/s41181-022-00158-z)
- Fenwick, A. J., Collins, S. M., Evans, W. D., Ferreira, K. M., Paisey, S. J., Robinson, A. P. and Marshall, C. 2020. Absolute standardisation and determination of the half-life and gamma emission intensities of 89Zr. Applied Radiation and Isotopes 166, article number: 109294. (10.1016/j.apradiso.2020.109294)
- Cavaliere, A. et al. 2020. Radiosynthesis of [18F]-labelled pro-nucleotides (ProTides). Molecules 25(3), article number: 704. (10.3390/molecules25030704)
- Watson, H. A. et al. 2019. L-selectin enhanced T cells improve the efficacy of cancer immunotherapy. Frontiers in Immunology 10, article number: 1321. (10.3389/fimmu.2019.01321)
- Whone, A. L. et al. 2019. Extended treatment with glial cell line-derived neurotrophic factor in Parkinson's Disease. Journal of Parkinson's Disease 9(2), pp. 301-313. (10.3233/JPD-191576)
- Foley, K., Christian, A., Peaker, J., Marshall, C., Spezi, E., Kynaston, H. and Roberts, S. A. 2019. Cyclo-oxygenase-2 expression is associated with mean standardised uptake value on 18F-fluorodeoxyglucose positron emission tomography in oesophageal adenocarcinoma. British Journal of Radiology 92(1099), article number: 20180668. (10.1259/bjr.20180668)
- Parkinson, C. et al. 2019. Machine-learned target volume delineation of 18F-FDG PET images after one cycle of induction chemotherapy. Physica Medica, European Journal of Medical Physics 61, pp. 85-93. (10.1016/j.ejmp.2019.04.020)
- Whone, A. et al. 2019. Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease. Brain 142(3), pp. 512-525. (10.1093/brain/awz023)
- Parkinson, C. et al. 2018. Evaluation of prognostic models developed using standardised image features from different PET automated segmentation methods. EJNMMI Research 8, article number: 29. (10.1186/s13550-018-0379-3)
- Parkinson, C. et al. 2018. Target volume delineation of PET post one cycle of induction chemotherapy in oropharyngeal cancer. Radiotherapy and Oncology 127(S1), pp. S634-S635., article number: EP-1126. (10.1016/S0167-8140(18)31436-1)
- Parkinson, C., Chan, J., Syndikus, I., Marshall, C., Staffurth, J. and Spezi, E. 2017. Impact of 18F-Choline PET scan acquisition time on delineation of GTV in prostate cancer [Poster Abstract]. Radiotherapy and Oncology 123(S1), pp. S714-S715. (10.1016/S0167-8140(17)31768-1)
- Berthon, B. et al. 2017. Head and neck target delineation using a novel PET automatic segmentation algorithm. Radiotherapy and Oncology 122(2), pp. 242-247. (10.1016/j.radonc.2016.12.008)
- Jolles, S., Carne, E., Brouns, M., El-Shanawany, T., Williams, P., Marshall, C. and Fielding, P. 2017. FDG PET-CT imaging of therapeutic response in granulomatous lymphocytic interstitial lung disease (GLILD) in common variable immunodeficiency (CVID). Clinical & Experimental Immunology 187(1), pp. 138-145. (10.1111/cei.12856)
- Berthon, B., Marshall, C., Evans, M. and Spezi, E. 2016. ATLAAS: an automatic decision tree-based learning algorithm for advanced image segmentation in positron emission tomography. Physics in Medicine and Biology 61(13), pp. 4855-4869. (10.1088/0031-9155/61/13/4855)
- Berthon, B. et al. 2015. PETSTEP: Generation of synthetic PET lesions for fast evaluation of segmentation methods. Physica Medica 31(8), pp. 969-980. (10.1016/j.ejmp.2015.07.139)
- Marshall, C. et al. 2015. Implementation of routine production of [18F]-fallypride on the TRASIS all-in-one universal synthesizer. European Journal of Nuclear Medicine and Molecular Imaging 42(S1), pp. S479. (10.1007/s00259-015-3198-z)
- Dabkowski, A. M., Paisey, S. J., Talboys, M. and Marshall, C. 2015. Optimization of cyclotron production for radiometal of Zirconium 89. Acta Physica Polonica Series A 127(5), pp. 1479-1482. (10.12693/APhysPolA.127.1479)
- Berthon, B., Marshall, C., Holmes, R. and Spezi, E. 2015. A novel phantom technique for evaluating the performance of PET auto-segmentation methods in delineating heterogeneous and irregular lesions. EJNMMI Physics 2(1), article number: 13. (10.1186/s40658-015-0116-1)
- Marshall, C., Talboys, M., Bukhari, S. and Evans, W. 2014. Quantification of the activity of tritium produced during the routine synthesis of 18F fluorodeoxyglucose for positron emission tomography. Journal of Radiological Protection 34(2), pp. 435-444. (10.1088/0952-4746/34/2/435)
- Berthon, B., Marshall, C., Edwards, A., Evans, M. and Spezi, E. 2013. Influence of cold walls on PET image quantification and volume segmentation: A phantom study. Medical Physics 40(8), article number: 82505. (10.1118/1.4813302)
- Ferguson, D., Orr, P., Gillanders, J., Corrigan, G. and Marshall, C. 2011. Measurement of long lived radioactive impurities retained in the disposable cassettes on the Tracerlab MX system during the production of [18F]FDG. Applied Radiation and Isotopes 69(10), pp. 1479-1485. (10.1016/j.apradiso.2011.05.028)
- Ferguson, D., McGrath, S., O'Hara, G. and Marshall, C. 2011. Investigation of staff finger doses during quality control of FDG production. Health Physics 100(5), pp. 523-529. (10.1097/HP.0b013e3181f1e9b5)
