![Joanna Martin](https://profiles-cardiff.imgix.net/attachments/4669?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Trosolwyg
Rwy'n Uwch Gymrawd Ymchwil sy'n gysylltiedig â Chanolfan Wolfson ar gyfer Iechyd Meddwl Pobl Ifanc a'r Ganolfan Geneteg a Genomeg Niwroseiciatrig. Rwy'n cael fy ariannu gan Gymrodoriaeth Uwch NIHR, Ymchwil Iechyd a Gofal Cymru. Mae fy mhrosiect cymrodoriaeth yn dwyn y teitl: "Gwella gwybodaeth, ymwybyddiaeth, a diagnosis o anhwylder gorfywiogrwydd diffyg sylw (ADHD) mewn menywod ifanc".
Fy ffocws ymchwil yw deall pam mae menywod yn llai tebygol na dynion o gael diagnosis o ADHD, yn ogystal â gwella gwybodaeth a diagnosis amserol o ADHD mewn plant a phobl ifanc. Mae gen i ddiddordeb hefyd yn effaith ffactorau risg genetig ar iechyd meddwl plant a chyflyrau niwroddatblygiadol, yn ogystal â nodweddion poblogaeth cysylltiedig. Mae fy ymchwil yn pontio meysydd epidemioleg, seiciatreg, a genomeg.
Cyhoeddiad
2025
- Williams, T. et al. 2025. An item-level systematic review of the presentation of ADHD in females. Neuroscience and Behavioural Reviews 171, article number: 106064. (10.1016/j.neubiorev.2025.106064)
- Dennison, C. A. et al. 2025. Early manifestations of neurodevelopmental copy number variants in children: A population-based investigation. Biological Psychiatry (10.1016/j.biopsych.2025.03.004)
- Horstmann, L., Dennison, C. A., Stergiakouli, E., Langley, K. and Martin, J. 2025. Attention Deficit Hyperactivity Disorder and other neurodevelopmental traits are associated with impact on functioning among children in the general population. JCPP Advances, article number: e70004. (10.1002/jcv2.70004)
2024
- Riglin, L. et al. 2024. Emotional problems across development: examining measurement invariance across childhood, adolescence and early adulthood. European Child and Adolescent Psychiatry 33, pp. 4237-4245. (10.1007/s00787-024-02461-3)
- Martin, J. et al. 2024. Sex differences in ADHD diagnosis and clinical care: A national study of population healthcare records in Wales. Journal of Child Psychology and Psychiatry 65(12), pp. 1648-1658. (10.1111/jcpp.13987)
- Barclay, I. et al. 2024. Investigating the reasons behind a later or missed diagnosis of Attention-Deficit/Hyperactivity Disorder in young people: a population cohort study. JCPP Advances (10.1002/jcv2.12301)
- Martin, J. 2024. Why are females less likely to be diagnosed with ADHD in childhood than males?. The Lancet Psychiatry 11(4), pp. 303-310. (10.1016/S2215-0366(24)00010-5)
- Capawana, M. et al. 2024. Polygenic variation underlying educational attainment and attention-deficit/hyperactivity disorder indexes behavior ratings of executive functions in child psychiatry outpatients. Journal of Attention Disorders 28(5) (10.1177/10870547231219763)
- Shakeshaft, A., Martin, J., Dennison, C. A., Riglin, L., Lewis, C. M., O'Donovan, M. and Thapar, A. 2024. Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems. Molecular Psychiatry 29, pp. 238-246. (10.1038/s41380-023-02319-1)
- Dennison, C. et al. 2024. Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry. Journal of Child Psychology and Psychiatry 65(1), pp. 42-51. (10.1111/jcpp.13862)
2023
- Gosling, C. J. et al. 2023. Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis. The Lancet Psychiatry 10(12), pp. 922-933. (10.1016/S2215-0366(23)00272-9)
- Wang, S. et al. 2023. Rare X-linked variants carry predominantly male risk in Autism, Tourette Syndrome, and ADHD. Nature Communications 14, article number: 8077. (10.1038/s41467-023-43776-0)
- Taylor, M. J. et al. 2023. A twin study of genetic and environmental contributions to attention-deficit/hyperactivity disorder over time. Journal of Child Psychology and Psychiatry 64(11) (10.1111/jcpp.13854)
- Devaney, J. et al. 2023. An agenda for future research regarding the mental health of young people with care experience. Child & Family Social Work 28(4), pp. 960-970. (10.1111/cfs.13015)
- Weavers, B. et al. 2023. Characterising depression trajectories in young people at high familial risk of depression. Journal of Affective Disorders 337, pp. 66-74. (10.1016/j.jad.2023.05.063)
- Jonsson, L., Martin, J., Lichtenstein, P., Magnusson, P. K. E., Lundström, S., Westberg, L. and Tammimies, K. 2023. Examining neurodevelopmental problems in 15q11.2 (BP1‐BP2) copy number variation carriers at ages 9/12 and 18 in a Swedish twin sample. Molecular Genetics and Genomic Medicine 11(8), article number: e2191. (10.1002/mgg3.2191)
- Lewis, K., Martin, J., Gregory, A. M., Anney, R., Thapar, A. and Langley, K. 2023. Sleep disturbances in ADHD: Investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes. European Child and Adolescent Psychiatry 32, pp. 1253-1261. (10.1007/s00787-021-01931-2)
- Khramtsova, E. A., Wilson, M. A., Martin, J., Winham, S. J., He, K. Y., Davis, L. K. and Stranger, B. E. 2023. Quality control and analytic best practices for testing genetic models of sex differences in large populations. Cell 186(10), pp. 2044-2061. (10.1016/j.cell.2023.04.014)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Demontis, D. et al. 2023. Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. Nature Genetics 55, pp. 198-208. (10.1038/s41588-022-01285-8)
- Cortese, S. et al. 2023. Candidate diagnostic biomarkers for neurodevelopmental disorders in children and adolescents: a systematic review. World Psychiatry 22(1), pp. 129-149. (10.1002/wps.21037)
- Rajagopal, V. M. et al. 2023. Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity. Scientific Reports 13(1), article number: 429. (10.1038/s41598-022-26845-0)
- Martin, J. et al. 2023. Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios. Biological Psychiatry 93(1), pp. 37-44. (10.1016/j.biopsych.2022.06.008)
2022
- Taylor, M., Ronald, A., Martin, J., Lundström, S., Hosang, G. and Lichtenstein, P. 2022. Examining the association between autistic traits in childhood and adolescent hypomania: a longitudinal twin study. Psychological Medicine 52(15), pp. 3606-3615. (10.1017/S0033291721000374)
- Vainieri, I. et al. 2022. Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments. Psychological Medicine 52(14), pp. 3150-3158. (10.1017/S0033291720005218)
- Mattheisen, M. et al. 2022. Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups. Nature Genetics 54, pp. 1470-1478. (10.1038/s41588-022-01171-3)
- Martini, M. et al. 2022. Sex differences in mental health problems and psychiatric hospitalization in autistic young adults. JAMA Psychiatry
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention-deficit hyperactivity disorder. In: Stanford, S. C. and Sciberras, E. eds. Current Topics in Behavioral Neurosciences. Berlin, Heidelberg: Springer, pp. 1-26., (10.1007/7854_2022_338)
- Garcia-Argibay, M. et al. 2022. The role of ADHD genetic risk in mid-to-late life somatic health conditions. Translational Psychiatry 12(1), article number: 152. (10.1038/s41398-022-01919-9)
- Martin, J. and Hadwin, J. 2022. The roles of sex and gender in child and adolescent mental health. JCPP Advances 2(1) (10.1002/jcv2.12059)
- Hosang, G. et al. 2022. Association of etiological factors for hypomanic symptoms, bipolar disorder, and other severe mental illnesses. JAMA Psychiatry 79(2), pp. 143-150. (10.1001/jamapsychiatry.2021.3654)
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention deficit hyperactivity disorder. Springer Nature.
2021
- Ghirardi, L. et al. 2021. Familial and genetic associations between autism spectrum disorder and other neurodevelopmental and psychiatric disorders. Journal of Child Psychology and Psychiatry 62(11), pp. 1274-1284. (10.1111/jcpp.13508)
- Martin, J. et al. 2021. Sex differences in anxiety and depression in children with ADHD investigating genetic liability and comorbidity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186(7), pp. 412-422. (10.1002/ajmg.b.32842)
- Brikell, I., Burton, C., Roth Mota, N. and Martin, J. 2021. Insights into attention-deficit/hyperactivity disorder from recent genetic studies. Psychological Medicine 51(13), pp. 2274-2286. (10.1017/S0033291721000982)
- Martin, J. et al. 2021. Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression. PLoS ONE 16(9), article number: e0248254. (10.1371/journal.pone.0248254)
- Ip, H. F. et al. 2021. Genetic association study of childhood aggression across raters, instruments, and age. Translational Psychiatry 11(1), article number: 413. (10.1038/s41398-021-01480-x)
- Martin, J. et al. 2021. Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits. Biological Psychiatry 89(12), pp. 1127-1137. (10.1016/j.biopsych.2020.12.024)
- Powell, V., Martin, J., Thapar, A., Rice, F. and Anney, R. 2021. Investigating regions of shared genetic variation in attention deficit/hyperactivity disorder and major depressive disorder: a GWAS meta-analysis. Scientific Reports 11, article number: 7353. (10.1038/s41598-021-86802-1)
- Demontis, D. et al. 2021. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder. Nature Communications 12(1), article number: 576. (10.1038/s41467-020-20443-2)
2020
- Powell, V. et al. 2020. What explains the link between childhood ADHD and adolescent depression? Investigating the role of peer relationships and academic attainment. European Child and Adolescent Psychiatry 29, pp. 1581-1591. (10.1007/s00787-019-01463-w)
- Vuijk, P. J. et al. 2020. Translating discoveries in Attention-Deficit/Hyperactivity Disorder genomics to an outpatient child and adolescent psychiatric cohort. Journal of the American Academy of Child and Adolescent Psychiatry 59(8), pp. 964-977. (10.1016/j.jaac.2019.08.004)
- Martin, J. et al. 2020. Investigating sex-specific effects of familial risk for ADHD and other neurodevelopmental disorders in the Swedish population. Bjpsych Open 6(4), article number: e65. (10.1192/bjo.2020.47)
- Riglin, L. et al. 2020. Using genetics to examine a general liability to childhood psychopathology. Behavior Genetics 50, pp. 213-220. (10.1007/s10519-019-09985-4)
- Martin, J. et al. 2020. A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder. Translational Psychiatry 10, article number: 135. (10.1038/s41398-020-0821-y)
2019
- Lee, P. H. et al. 2019. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7), pp. 1469-1482.e11. (10.1016/j.cell.2019.11.020)
- Yao, S. et al. 2019. Associations between Attention-Deficit/Hyperactivity Disorder and various eating disorders: A Swedish nationwide population study using multiple genetically informative approaches. Biological Psychiatry 86(8), pp. 577-586. (10.1016/j.biopsych.2019.04.036)
- Mowlem, F. D., Rosenqvist, M. A., Martin, J., Lichtenstein, P., Asherson, P. and Larsson, H. 2019. Sex differences in predicting ADHD clinical diagnosis and pharmacological treatment. European Child and Adolescent Psychiatry 28(4), pp. 481-489. (10.1007/s00787-018-1211-3)
- Grove, J. et al. 2019. Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics 51, pp. 431-444. (10.1038/s41588-019-0344-8)
- Taylor, M. J., Martin, J., Lu, Y., Brikell, I., Lundstrom, S., Larsson, H. and Lichtenstein, P. 2019. Association of genetic risk factors for psychiatric disorders and traits of these disorders in a Swedish population twin sample. JAMA Psychiatry 76(3), pp. 280-289. (10.1001/jamapsychiatry.2018.3652)
- Verhoef, E. et al. 2019. Disentangling polygenic associations between attention-deficit/hyperactivity disorder, educational attainment, literacy and language. Translational Psychiatry 9, article number: 35. (10.1038/s41398-018-0324-2)
2018
- Demontis, D. et al. 2018. Discovery of the first genome-wide significant risk loci for attention-deficit/hyperactivity disorder. Nature Genetics 51, pp. 63-75. (10.1038/s41588-018-0269-7)
- Martin, J., Tammimes, K., Karlsson, R., Lu, Y., Larsson, H., Lichtenstein, P. and Magnusson, P. K. 2018. Copy number variation and neuropsychiatric problems in females and males in the general population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180(6), pp. 341-350. (10.1002/ajmg.b.32685)
- Martin, J. et al. 2018. Sex-specific manifestation of genetic risk for attention deficit hyperactivity disorder in the general population. Journal of Child Psychology and Psychiatry 59(8), pp. 908-916. (10.1111/jcpp.12874)
- Martin, J., Taylor, M. J. and Lichtenstein, P. 2018. Assessing the evidence for shared genetic risks across psychiatric disorders and traits. Psychological Medicine 48(11), pp. 1759-1774. (10.1017/S0033291717003440)
- Guyatt, A. L. et al. 2018. Association of copy number variation across the genome with neuropsychiatric traits in the general population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(5), pp. 489-502. (10.1002/ajmg.b.32637)
- Brikell, I. et al. 2018. The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology. Molecular Psychiatry (10.1038/s41380-018-0109-2)
- Martin, J. et al. 2018. A genetic investigation of sex bias in the prevalence of attention-deficit/hyperactivity disorder. Biological Psychiatry 83(12), pp. 1044-1053. (10.1016/j.biopsych.2017.11.026)
2017
- Riglin, L. et al. 2017. Investigating the genetic underpinnings of early-life irritability. Translational Psychiatry 7, article number: e1241. (10.1038/tp.2017.212)
- Stergiakouli, E. et al. 2017. Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population. International Journal of Epidemiology 46(2), pp. 421-428. (10.1093/ije/dyw216)
- Stergiakouli, E. et al. 2017. Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development. Molecular Autism 8, article number: 18. (10.1186/s13229-017-0131-2)
2016
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
- Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
- Martin, J. et al. 2016. Association of genetic risk for schizophrenia with nonparticipation over time in a population-based cohort study. American Journal of Epidemiology 183(12), pp. 1149-1158. (10.1093/aje/kww009)
- Robinson, E. B. et al. 2016. Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nature Genetics 48(5), pp. 552-555. (10.1038/ng.3529)
- Isles, A. R. et al. 2016. Parental origin of interstitial duplications at 15q11.2-q13.3 in schizophrenia and neurodevelopmental disorders. PLoS Genetics 12(5), article number: e1005993. (10.1371/journal.pgen.1005993)
- Aas, M. et al. 2016. Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014 [Conference Material]. Psychiatric Genetics 26(1), pp. 1-47. (10.1097/YPG.0000000000000112)
2015
- Niarchou, M., Martin, J., Thapar, A., Owen, M. J. and van den Bree, M. B. 2015. The clinical presentation of attention deficit-hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 168(8), pp. 730-738. (10.1002/ajmg.b.32378)
- Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2015. Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry 56(6), pp. 648-656. (10.1111/jcpp.12336)
- Stergiakouli, E. et al. 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54(4), pp. 322-327. (10.1016/j.jaac.2015.01.010)
- Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5, article number: e506. (10.1038/tp.2015.5)
2014
- Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2014. Genetic risk for Attention Deficit/Hyperactivity Disorder contributes to neurodevelopmental traits in the general population. Biological Psychiatry 76(8), pp. 664-671. (10.1016/j.biopsych.2014.02.013)
- Martin, J. et al. 2014. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry 53(7), pp. 761-770.e26. (10.1016/j.jaac.2014.03.004)
- Cooper, M., Martin, J., Langley, K., Hamshere, M. L. and Thapar, A. 2014. Autistic traits in children with ADHD index clinical and cognitive problems. European Child & Adolescent Psychiatry 23(1), pp. 23-24. (10.1007/s00787-013-0398-6)
- Martin, J., Hamshere, M. L., O'Donovan, M. C., Rutter, M. and Thapar, A. 2014. Factor structure of autistic traits in children with ADHD. Journal of Autism and Developmental Disorders 44(1), pp. 204-215. (10.1007/s10803-013-1865-0)
- Martin, J. 2014. Examining the clinical and genetic overlap of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder traits. PhD Thesis, Cardiff University.
2013
- Ahuja, A., Martin, J., Langley, K. and Thapar, A. 2013. Intellectual disability in children with attention deficit hyperactivity disorder. The Journal of Pediatrics 163(3), pp. 890-895.e1. (10.1016/j.jpeds.2013.02.043)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
- Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
2011
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.
Articles
- Williams, T. et al. 2025. An item-level systematic review of the presentation of ADHD in females. Neuroscience and Behavioural Reviews 171, article number: 106064. (10.1016/j.neubiorev.2025.106064)
- Dennison, C. A. et al. 2025. Early manifestations of neurodevelopmental copy number variants in children: A population-based investigation. Biological Psychiatry (10.1016/j.biopsych.2025.03.004)
- Horstmann, L., Dennison, C. A., Stergiakouli, E., Langley, K. and Martin, J. 2025. Attention Deficit Hyperactivity Disorder and other neurodevelopmental traits are associated with impact on functioning among children in the general population. JCPP Advances, article number: e70004. (10.1002/jcv2.70004)
- Riglin, L. et al. 2024. Emotional problems across development: examining measurement invariance across childhood, adolescence and early adulthood. European Child and Adolescent Psychiatry 33, pp. 4237-4245. (10.1007/s00787-024-02461-3)
- Martin, J. et al. 2024. Sex differences in ADHD diagnosis and clinical care: A national study of population healthcare records in Wales. Journal of Child Psychology and Psychiatry 65(12), pp. 1648-1658. (10.1111/jcpp.13987)
- Barclay, I. et al. 2024. Investigating the reasons behind a later or missed diagnosis of Attention-Deficit/Hyperactivity Disorder in young people: a population cohort study. JCPP Advances (10.1002/jcv2.12301)
- Martin, J. 2024. Why are females less likely to be diagnosed with ADHD in childhood than males?. The Lancet Psychiatry 11(4), pp. 303-310. (10.1016/S2215-0366(24)00010-5)
- Capawana, M. et al. 2024. Polygenic variation underlying educational attainment and attention-deficit/hyperactivity disorder indexes behavior ratings of executive functions in child psychiatry outpatients. Journal of Attention Disorders 28(5) (10.1177/10870547231219763)
- Shakeshaft, A., Martin, J., Dennison, C. A., Riglin, L., Lewis, C. M., O'Donovan, M. and Thapar, A. 2024. Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems. Molecular Psychiatry 29, pp. 238-246. (10.1038/s41380-023-02319-1)
- Dennison, C. et al. 2024. Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry. Journal of Child Psychology and Psychiatry 65(1), pp. 42-51. (10.1111/jcpp.13862)
- Gosling, C. J. et al. 2023. Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis. The Lancet Psychiatry 10(12), pp. 922-933. (10.1016/S2215-0366(23)00272-9)
- Wang, S. et al. 2023. Rare X-linked variants carry predominantly male risk in Autism, Tourette Syndrome, and ADHD. Nature Communications 14, article number: 8077. (10.1038/s41467-023-43776-0)
- Taylor, M. J. et al. 2023. A twin study of genetic and environmental contributions to attention-deficit/hyperactivity disorder over time. Journal of Child Psychology and Psychiatry 64(11) (10.1111/jcpp.13854)
- Devaney, J. et al. 2023. An agenda for future research regarding the mental health of young people with care experience. Child & Family Social Work 28(4), pp. 960-970. (10.1111/cfs.13015)
- Weavers, B. et al. 2023. Characterising depression trajectories in young people at high familial risk of depression. Journal of Affective Disorders 337, pp. 66-74. (10.1016/j.jad.2023.05.063)
- Jonsson, L., Martin, J., Lichtenstein, P., Magnusson, P. K. E., Lundström, S., Westberg, L. and Tammimies, K. 2023. Examining neurodevelopmental problems in 15q11.2 (BP1‐BP2) copy number variation carriers at ages 9/12 and 18 in a Swedish twin sample. Molecular Genetics and Genomic Medicine 11(8), article number: e2191. (10.1002/mgg3.2191)
- Lewis, K., Martin, J., Gregory, A. M., Anney, R., Thapar, A. and Langley, K. 2023. Sleep disturbances in ADHD: Investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes. European Child and Adolescent Psychiatry 32, pp. 1253-1261. (10.1007/s00787-021-01931-2)
- Khramtsova, E. A., Wilson, M. A., Martin, J., Winham, S. J., He, K. Y., Davis, L. K. and Stranger, B. E. 2023. Quality control and analytic best practices for testing genetic models of sex differences in large populations. Cell 186(10), pp. 2044-2061. (10.1016/j.cell.2023.04.014)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Demontis, D. et al. 2023. Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. Nature Genetics 55, pp. 198-208. (10.1038/s41588-022-01285-8)
- Cortese, S. et al. 2023. Candidate diagnostic biomarkers for neurodevelopmental disorders in children and adolescents: a systematic review. World Psychiatry 22(1), pp. 129-149. (10.1002/wps.21037)
- Rajagopal, V. M. et al. 2023. Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity. Scientific Reports 13(1), article number: 429. (10.1038/s41598-022-26845-0)
- Martin, J. et al. 2023. Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios. Biological Psychiatry 93(1), pp. 37-44. (10.1016/j.biopsych.2022.06.008)
- Taylor, M., Ronald, A., Martin, J., Lundström, S., Hosang, G. and Lichtenstein, P. 2022. Examining the association between autistic traits in childhood and adolescent hypomania: a longitudinal twin study. Psychological Medicine 52(15), pp. 3606-3615. (10.1017/S0033291721000374)
- Vainieri, I. et al. 2022. Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments. Psychological Medicine 52(14), pp. 3150-3158. (10.1017/S0033291720005218)
- Mattheisen, M. et al. 2022. Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups. Nature Genetics 54, pp. 1470-1478. (10.1038/s41588-022-01171-3)
- Martini, M. et al. 2022. Sex differences in mental health problems and psychiatric hospitalization in autistic young adults. JAMA Psychiatry
- Garcia-Argibay, M. et al. 2022. The role of ADHD genetic risk in mid-to-late life somatic health conditions. Translational Psychiatry 12(1), article number: 152. (10.1038/s41398-022-01919-9)
- Martin, J. and Hadwin, J. 2022. The roles of sex and gender in child and adolescent mental health. JCPP Advances 2(1) (10.1002/jcv2.12059)
- Hosang, G. et al. 2022. Association of etiological factors for hypomanic symptoms, bipolar disorder, and other severe mental illnesses. JAMA Psychiatry 79(2), pp. 143-150. (10.1001/jamapsychiatry.2021.3654)
- Ghirardi, L. et al. 2021. Familial and genetic associations between autism spectrum disorder and other neurodevelopmental and psychiatric disorders. Journal of Child Psychology and Psychiatry 62(11), pp. 1274-1284. (10.1111/jcpp.13508)
- Martin, J. et al. 2021. Sex differences in anxiety and depression in children with ADHD investigating genetic liability and comorbidity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186(7), pp. 412-422. (10.1002/ajmg.b.32842)
- Brikell, I., Burton, C., Roth Mota, N. and Martin, J. 2021. Insights into attention-deficit/hyperactivity disorder from recent genetic studies. Psychological Medicine 51(13), pp. 2274-2286. (10.1017/S0033291721000982)
- Martin, J. et al. 2021. Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression. PLoS ONE 16(9), article number: e0248254. (10.1371/journal.pone.0248254)
- Ip, H. F. et al. 2021. Genetic association study of childhood aggression across raters, instruments, and age. Translational Psychiatry 11(1), article number: 413. (10.1038/s41398-021-01480-x)
- Martin, J. et al. 2021. Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits. Biological Psychiatry 89(12), pp. 1127-1137. (10.1016/j.biopsych.2020.12.024)
- Powell, V., Martin, J., Thapar, A., Rice, F. and Anney, R. 2021. Investigating regions of shared genetic variation in attention deficit/hyperactivity disorder and major depressive disorder: a GWAS meta-analysis. Scientific Reports 11, article number: 7353. (10.1038/s41598-021-86802-1)
- Demontis, D. et al. 2021. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder. Nature Communications 12(1), article number: 576. (10.1038/s41467-020-20443-2)
- Powell, V. et al. 2020. What explains the link between childhood ADHD and adolescent depression? Investigating the role of peer relationships and academic attainment. European Child and Adolescent Psychiatry 29, pp. 1581-1591. (10.1007/s00787-019-01463-w)
- Vuijk, P. J. et al. 2020. Translating discoveries in Attention-Deficit/Hyperactivity Disorder genomics to an outpatient child and adolescent psychiatric cohort. Journal of the American Academy of Child and Adolescent Psychiatry 59(8), pp. 964-977. (10.1016/j.jaac.2019.08.004)
- Martin, J. et al. 2020. Investigating sex-specific effects of familial risk for ADHD and other neurodevelopmental disorders in the Swedish population. Bjpsych Open 6(4), article number: e65. (10.1192/bjo.2020.47)
- Riglin, L. et al. 2020. Using genetics to examine a general liability to childhood psychopathology. Behavior Genetics 50, pp. 213-220. (10.1007/s10519-019-09985-4)
- Martin, J. et al. 2020. A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder. Translational Psychiatry 10, article number: 135. (10.1038/s41398-020-0821-y)
- Lee, P. H. et al. 2019. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7), pp. 1469-1482.e11. (10.1016/j.cell.2019.11.020)
- Yao, S. et al. 2019. Associations between Attention-Deficit/Hyperactivity Disorder and various eating disorders: A Swedish nationwide population study using multiple genetically informative approaches. Biological Psychiatry 86(8), pp. 577-586. (10.1016/j.biopsych.2019.04.036)
- Mowlem, F. D., Rosenqvist, M. A., Martin, J., Lichtenstein, P., Asherson, P. and Larsson, H. 2019. Sex differences in predicting ADHD clinical diagnosis and pharmacological treatment. European Child and Adolescent Psychiatry 28(4), pp. 481-489. (10.1007/s00787-018-1211-3)
- Grove, J. et al. 2019. Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics 51, pp. 431-444. (10.1038/s41588-019-0344-8)
- Taylor, M. J., Martin, J., Lu, Y., Brikell, I., Lundstrom, S., Larsson, H. and Lichtenstein, P. 2019. Association of genetic risk factors for psychiatric disorders and traits of these disorders in a Swedish population twin sample. JAMA Psychiatry 76(3), pp. 280-289. (10.1001/jamapsychiatry.2018.3652)
- Verhoef, E. et al. 2019. Disentangling polygenic associations between attention-deficit/hyperactivity disorder, educational attainment, literacy and language. Translational Psychiatry 9, article number: 35. (10.1038/s41398-018-0324-2)
- Demontis, D. et al. 2018. Discovery of the first genome-wide significant risk loci for attention-deficit/hyperactivity disorder. Nature Genetics 51, pp. 63-75. (10.1038/s41588-018-0269-7)
- Martin, J., Tammimes, K., Karlsson, R., Lu, Y., Larsson, H., Lichtenstein, P. and Magnusson, P. K. 2018. Copy number variation and neuropsychiatric problems in females and males in the general population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180(6), pp. 341-350. (10.1002/ajmg.b.32685)
- Martin, J. et al. 2018. Sex-specific manifestation of genetic risk for attention deficit hyperactivity disorder in the general population. Journal of Child Psychology and Psychiatry 59(8), pp. 908-916. (10.1111/jcpp.12874)
- Martin, J., Taylor, M. J. and Lichtenstein, P. 2018. Assessing the evidence for shared genetic risks across psychiatric disorders and traits. Psychological Medicine 48(11), pp. 1759-1774. (10.1017/S0033291717003440)
- Guyatt, A. L. et al. 2018. Association of copy number variation across the genome with neuropsychiatric traits in the general population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(5), pp. 489-502. (10.1002/ajmg.b.32637)
- Brikell, I. et al. 2018. The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology. Molecular Psychiatry (10.1038/s41380-018-0109-2)
- Martin, J. et al. 2018. A genetic investigation of sex bias in the prevalence of attention-deficit/hyperactivity disorder. Biological Psychiatry 83(12), pp. 1044-1053. (10.1016/j.biopsych.2017.11.026)
- Riglin, L. et al. 2017. Investigating the genetic underpinnings of early-life irritability. Translational Psychiatry 7, article number: e1241. (10.1038/tp.2017.212)
- Stergiakouli, E. et al. 2017. Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population. International Journal of Epidemiology 46(2), pp. 421-428. (10.1093/ije/dyw216)
- Stergiakouli, E. et al. 2017. Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development. Molecular Autism 8, article number: 18. (10.1186/s13229-017-0131-2)
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
- Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
- Martin, J. et al. 2016. Association of genetic risk for schizophrenia with nonparticipation over time in a population-based cohort study. American Journal of Epidemiology 183(12), pp. 1149-1158. (10.1093/aje/kww009)
- Robinson, E. B. et al. 2016. Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nature Genetics 48(5), pp. 552-555. (10.1038/ng.3529)
- Isles, A. R. et al. 2016. Parental origin of interstitial duplications at 15q11.2-q13.3 in schizophrenia and neurodevelopmental disorders. PLoS Genetics 12(5), article number: e1005993. (10.1371/journal.pgen.1005993)
- Aas, M. et al. 2016. Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014 [Conference Material]. Psychiatric Genetics 26(1), pp. 1-47. (10.1097/YPG.0000000000000112)
- Niarchou, M., Martin, J., Thapar, A., Owen, M. J. and van den Bree, M. B. 2015. The clinical presentation of attention deficit-hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 168(8), pp. 730-738. (10.1002/ajmg.b.32378)
- Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2015. Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry 56(6), pp. 648-656. (10.1111/jcpp.12336)
- Stergiakouli, E. et al. 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54(4), pp. 322-327. (10.1016/j.jaac.2015.01.010)
- Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5, article number: e506. (10.1038/tp.2015.5)
- Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2014. Genetic risk for Attention Deficit/Hyperactivity Disorder contributes to neurodevelopmental traits in the general population. Biological Psychiatry 76(8), pp. 664-671. (10.1016/j.biopsych.2014.02.013)
- Martin, J. et al. 2014. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry 53(7), pp. 761-770.e26. (10.1016/j.jaac.2014.03.004)
- Cooper, M., Martin, J., Langley, K., Hamshere, M. L. and Thapar, A. 2014. Autistic traits in children with ADHD index clinical and cognitive problems. European Child & Adolescent Psychiatry 23(1), pp. 23-24. (10.1007/s00787-013-0398-6)
- Martin, J., Hamshere, M. L., O'Donovan, M. C., Rutter, M. and Thapar, A. 2014. Factor structure of autistic traits in children with ADHD. Journal of Autism and Developmental Disorders 44(1), pp. 204-215. (10.1007/s10803-013-1865-0)
- Ahuja, A., Martin, J., Langley, K. and Thapar, A. 2013. Intellectual disability in children with attention deficit hyperactivity disorder. The Journal of Pediatrics 163(3), pp. 890-895.e1. (10.1016/j.jpeds.2013.02.043)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
- Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.
Book sections
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention-deficit hyperactivity disorder. In: Stanford, S. C. and Sciberras, E. eds. Current Topics in Behavioral Neurosciences. Berlin, Heidelberg: Springer, pp. 1-26., (10.1007/7854_2022_338)
Books
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention deficit hyperactivity disorder. Springer Nature.
Thesis
- Martin, J. 2014. Examining the clinical and genetic overlap of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder traits. PhD Thesis, Cardiff University.
Bywgraffiad
Rwyf wedi derbyn cyllid ar gyfer fy ymchwil drwy Gymrodoriaeth Uwch Ymchwil Iechyd a Gofal Cymru/NIHR, Grant Ymchwilydd Ifanc NARSAD gan Sefydliad Ymchwil Ymennydd ac Ymddygiad, gwobr COFUND Sêr Cymru gan Lywodraeth Cymru/UE, a Chymrodoriaeth Ôl-ddoethurol Syr Henry Wellcome.
Fel rhan o gymrodoriaeth Ymddiriedolaeth Wellcome, roeddwn yn gweithio yng Nghanolfan Ymchwil Seiciatrig Stanley (Caergrawnt, UDA) a'r Adran Epidemioleg a Bioystadegau Meddygol, Karolinska Institutet (Stockholm, Sweden), yn ogystal â Chanolfan MRC ar gyfer Geneteg a Genomeg Niwroseiciatrig ym Mhrifysgol Caerdydd.
Cwblheais fy PhD yn yr adran Seiciatreg Plant a'r Glasoed yng Nghanolfan MRC ar gyfer Geneteg a Genomeg Niwroseiciatrig yn 2014. Teitl fy nhraethawd ymchwil oedd "Archwilio Gorgyffwrdd Clinigol a Genetig Anhwylder Gorfywiogrwydd Diffyg Sylw a Nodweddion Anhwylder Sbectrwm Awtistiaeth" a gellir ei lawrlwytho'n rhydd.
Cyn fy PhD, cefais BSc mewn Seicoleg Arbrofol o Brifysgol Bryste ac yna gweithiais fel Cynorthwy-ydd Ymchwil ym Mhrifysgol Caerdydd, gan gasglu data a pherfformio dadansoddiadau fel rhan o Astudiaeth ADHD, Genes a'r Amgylchedd.
Anrhydeddau a dyfarniadau
Cymrodoriaethau a Grantiau
- Ymchwil Iechyd a Gofal Cymru/Cymrodoriaeth Uwch NIHR (2022)
- Grant Ymchwilydd Ifanc NARSAD gan Sefydliad Ymchwil Ymennydd ac Ymddygiad (2021)
- Gwobr Cymrodorion (MQ). Cyd-ymchwilydd (2021)
- MRC Glasoed, Iechyd Meddwl a'r Wobr Datblygu Meddwl: Ymgysylltu (MRC). Cyd-ymchwilydd (2020)
- Cymrodoriaeth MCSA COFUND Sêr Cymru wedi'i hariannu gan Horizon 2020 yr UE a Llywodraeth Cymru (2019)
- Cymrodoriaeth Ôl-ddoethurol Syr Henry Wellcome (2015)
Ysgoloriaethau a Gwobrau
- Gwobr Kramer-Pollnow am waith gwyddonol rhagorol ym maes ADHD (2021)
- Ysgoloriaeth Teithio Iau Sagvolden Eunethydis (2016)
- Gwobr Teithio ar gyfer Eunethydis 3ydd Cynhadledd Ryngwladol ADHD (2014)
- Grant Teithio i'r Gynhadledd, Y Gymdeithas Geneteg (2014)
- Grant Cymorth i Ymchwilwyr Cynnar, Prifysgol Caerdydd (2013)
- Gwobr Teithio Eunethydis 2il Cynhadledd Ryngwladol ADHD (2012)
- Ysgoloriaeth Gwyliau Ymddiriedolaeth Wellcome (2006)
- Grant Sylfaen Sidney Perry (2005/2006)
Safleoedd academaidd blaenorol
- Cymrawd Ymchwil (03.2019 – cyfredol) Canolfan MRC ar gyfer Geneteg a Genomeg Niwroseiciatrig, Prifysgol Caerdydd
- Syr Henry Wellcome Cymrawd Ôl-ddoethurol (03.2018 – 02.2019) Canolfan MRC ar gyfer Geneteg a Genomeg Niwroseiciatrig, Prifysgol Caerdydd
- Syr Henry Wellcome Cymrawd Ôl-ddoethurol (03.2016 – 02.2018) Adran Epidemioleg a Bioystadegau Meddygol, Karolinska Institutet, Stockholm, Sweden
- Syr Henry Wellcome Cymrawd Ôl-ddoethurol (02.2015 – 02.2016) Uned Geneteg Dadansoddol a Chyfieithol, Ysbyty Cyffredinol Massachusetts, Boston & Stanley Canolfan Ymchwil Seiciatrig, Sefydliad Broad MIT a Harvard, Caergrawnt, UDA
- Cyswllt Ymchwil (01.2015 – 02.2015) Canolfan MRC ar gyfer Geneteg a Genomeg Niwroseiciatrig, Prifysgol Caerdydd
- Myfyriwr PhD (01.2012 – 12.2014 ) Canolfan MRC ar gyfer Geneteg a Genomeg Niwroseiciatrig, Prifysgol Caerdydd
- Seicolegydd Ymchwil Cynorthwyol (02.2010 – 12.2011) Adran Meddygaeth Seicolegol, Prifysgol Caerdydd
Pwyllgorau ac adolygu
- Golygydd Cyswllt, JCPP Advances
- Aelod o'r Pwyllgor Amrywiaeth a Chynhwysedd Cydraddoldeb, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol, Prifysgol Caerdydd
- Consortiwm Genomeg Seiciatrig (PGC) Cynrychiolydd Pwyllgor Mynediad Data ar gyfer Gweithgor ADHD
- adolygydd cymheiriaid (amrywiol)
Meysydd goruchwyliaeth
Myfyrwyr presennol
Prif oruchwyliwr Isabella Barclay (2023 - presennol). Teitl traethawd ymchwil: Deall rhesymau posibl dros oedi o ran diagnosis ADHD mewn menywod. Cyd-oruchwylwyr: Dr Kate Langley, Yr Athro Anita Thapar, Dr Mark Taylor (Karolinska Institutet, Sweden).
Cyd-oruchwyliwr Bryony Weavers (2022 - presennol). Teitl traethawd ymchwil: Plant rhieni isel eu hysbryd: Adnabod targedau addawol ar gyfer ymyrraeth. Cyd-oruchwylwyr: Yr Athro Fran Rice, Dr Lucy Riglin, yr Athro Anita Thapar.
Cyd-oruchwyliwr Louise Horstmann (2021 - presennol). Teitl traethawd ymchwil: Deall goblygiadau defnyddio gwahanol ddiffiniadau o anhwylder diffyg canolbwyntio gorfywiogrwydd. Cyd-oruchwylwyr: Dr Kate Langley, Dr Evie Stergiakouli (Prifysgol Bryste).
Goruchwyliaeth gyfredol
