Yr Athro Deborah Mason
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Deborah Mason
Athro, Ysgol y Biowyddorau; Cyfarwyddwr Ymchwil Cyn-Glinigol
Ysgol y Biowyddorau
Trosolwyg
Rwy'n Gyd-Brif Ymchwilydd Canolfan Biomecaneg a Biobeirianneg Arthritis Research UK ym Mhrifysgol Caerdydd, lle rwy'n arwain y Rhaglen Ymchwil Cyn-glinigol sy'n ymchwilio i'r rhyngweithio rhwng biomecaneg a bioleg mewn meinweoedd ar y cyd. Rwyf wedi sefydlu platfform o fodelau celloedd, anifeiliaid a dynol i ymchwilio i sut mae llwyth mecanyddol yn rheoleiddio patholeg a phoen ar y cyd. Mae fy ymchwil yn egluro mecanweithiau signalau newydd sy'n rheoleiddio trosiant esgyrn a chartilag, i ddarparu targedau therapiwtig a diagnostig ar gyfer clefydau cyhyrysgerbydol. Mae hyn wedi arwain at ddarganfod signalau glutamatergig swyddogaethol mewn meinweoedd ar y cyd, ac wedi datgelu llwybrau newydd sy'n cyfryngu diraddiad cartilag a achosir gan cytocin a mecanyddol. Mae fy ymchwil yn canolbwyntio ar gyfieithu gwrthwynebwyr derbynnydd glutamad fel triniaeth ar gyfer osteoarthritis, nodi biomarcwyr wedi'u rheoleiddio'n fecanyddol a datblygu dynwared ar y cyd ar gyfer sgrinio cyffuriau.
Rwyf wedi arwain dros 40 o brosiectau ymchwil (a ariannwyd yn ddiweddar gan Industry, Orthopaedics Research UK, Wellcome Trust, EPSRC, Versus Arthritis, NC3Rs), wedi dyfeisio patentau ac wedi cydweithio ag academyddion, y GIG a chlinigwyr milfeddygol a diwydiant. Rwy'n Gymrawd Ymchwil Orthopedig Ryngwladol Coleg Cymrodyr Rhyngwladol ICORS i gydnabod statws proffesiynol rhagorol a chyflawniadau uchel ym maes ymchwil orthopedig.
Rolau
Caerdydd
- Arweinydd Modiwl BI3351 Pynciau Cyfoes mewn Clefyd
- Cyfarwyddwr Ymchwil Cyn-glinigol, Canolfan Ymchwil Biomechnics a Biobeirianneg yn erbyn Arthritis
Cenedlaethol
- Cyn-lywydd a Chadeirydd Ymddiriedolwyr, Cymdeithas Ymchwil Orthopedig Prydain
- Arweinydd Thema Drosi, Grŵp Cynghori Ymchwil Cyhyrysgerbydol, Yn erbyn Arthritis
- 'Treialon mewn poblogaethau mewn perygl' is-thema yn arwain yn Ffrwd Waith Cyflyrau Cyhyrysgerbydol Cyffredin NIHR Translational Research Collaboration
Oes gennych chi ddiddordeb mewn ymuno â'm labordy fel myfyriwr ôl-raddedig hunan-ariannu neu ôl-ddoethurol/cymrawd? Cysylltwch â mi trwy e-bost.
Cyhoeddiad
2024
- Jones, R., Gilbert, S. J., Christofides, S. R. and Mason, D. J. 2024. Osteocytes contribute to sex-specific differences in osteoarthritic pain. Frontiers in Endocrinology 15, article number: 1480274. (10.3389/fendo.2024.1480274)
- Kalsoum, R. et al. 2024. A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury.. Bone & Joint Research 13(9), pp. 513-524. (10.1302/2046-3758.139.BJR-2024-0109)
- Gilbert, S. J., Jones, R., Egan, B. J., Bonnet, C. S., Evans, S. L. and Mason, D. J. 2024. Investigating mechanical and inflammatory pathological mechanisms in osteoarthritis using MSC-derived osteocyte-like cells in 3D. Frontiers in Endocrinology 15, article number: 1359052. (10.3389/fendo.2024.1359052)
- Whittaker, J. L. et al. 2024. Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop. Osteoarthritis and Cartilage Open 6(2), article number: 100449. (10.1016/j.ocarto.2024.100449)
- Hamilton, R., Garcia, A. A., Bowd, J., Hamilton, D., Mason, D., Elliott, M. and Holt, C. 2024. Utilising electrodermal activity sensor signals to quantify nociceptive response during movement activities. BMC Research Notes 17, article number: 36. (10.1186/s13104-024-06689-9)
2023
- Hamilton, R. et al. 2023. Measuring osteoarthritis knee nociception using physiological and movement response and a defined thermal stimulus: A proof-of-concept study.. Presented at: The International Combined Orthopaedic Research Societies (ICORS), World Congress of Orthopaedic Research, Edinburgh, UK, 7-9 September 2022Orthopaedic Proceedings, Vol. 105-B,. pp. 20-20., (10.1302/1358-992X.2023.8.020)
2022
- Gilbert, S. J., Blain, E. J. and Mason, D. J. 2022. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms. Biochemistry and Biophysics Reports 32, article number: 101323. (10.1016/j.bbrep.2022.101323)
- Paskins, Z. et al. 2022. Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method. The Lancet Rheumatology 4(9), pp. 635-645. (10.1016/S2665-9913(22)00136-9)
2021
- Hamilton, R., Holt, C., Jones, R., Shillabeer, D., Sparkes, V. and Mason, D. 2021. Measuring nociception in knee osteoarthritis using physiological and movement responses: a proof-of-concept study. Presented at: British Orthopaedic Research Society, Cardiff, UK, 13-14 September 2021.
- Mason, D., Englund, M. and Watt, F. E. 2021. Prevention of posttraumatic osteoarthritis at the time of injury: Where are we now, and where are we going?. Journal of Orthopaedic Research 39(6), pp. 1152-1163. (10.1002/jor.24982)
2020
- Bonnet, C. S., Gilbert, S. J., Blain, E. J., Williams, A. S. and Mason, D. J. 2020. AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis. JCI Insight 5(13), article number: e134055. (10.1172/jci.insight.134055)
2019
- Khatib, N., Biggs, P., Wilson, C., Williams, R., Mason, D. and Holt, C. 2019. Dynamic medial knee overloading influences inflammation and bone remodeling in the degenerative knee [Abstract]. Osteoarthritis and Cartilage 27(S1), pp. S44., article number: 29. (10.1016/j.joca.2019.02.063)
- Simonovic, J., Holt, C. and Mason, D. 2019. Semantic insight and behaviour of the computational bone cell population models. Presented at: 25th Congress of the European Society of Biomechanics (ESB 2019), Vienna, Austria, 7-10 July 2019. pp. -.
- Watt, F. E. et al. 2019. Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury. Osteoarthritis and Cartilage 27(1), pp. 23-33. (10.1016/j.joca.2018.08.001)
2018
- Gilbert, S. J., Bonnet, C. S., Stadnik, P., Duance, V. C., Mason, D. J. and Blain, E. J. 2018. Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis. Journal of Orthopaedic Research 36(8), pp. 2118-2127. (10.1002/jor.23872)
- Jähn, K., Mason, D., Ralphs, J., Evans, B., Archer, C., Richards, R. G. and Stoddart, M. 2018. Phenotype and viability of MLO-Y4 cells Is maintained by TGFβ3 in a serum-dependent manner within a 3D-co-culture with MG-63 cells. International Journal of Molecular Sciences 19(7), article number: 1932. (10.3390/ijms19071932)
- Sanders, R., Bustin, S., Huggett, J. and Mason, D. 2018. Improving the standardization of mRNA measurement by RT-qPCR. Biomolecular Detection and Quantification 15, pp. 13-17. (10.1016/j.bdq.2018.03.001)
- Khatib, N., Papageorgiou, A., Vazquez, M., Flintoft, F., Holt, C. and Mason, D. 2018. How does an AMPA/KA receptor antagonist affect the metabolic profile of a bone co-culture loading model? an NMR spectroscopy approach [Abstract]. International Journal of Experimental Pathology 98(1), pp. A21. (10.1111/iep.12218)
2016
- Holt, C. A. et al. 2016. Biological changes in tibial subchondral bone following high tibial osteotomy. Osteoarthritis and Cartilage 24(S1), pp. S511-S511. (10.1016/j.joca.2016.01.935)
- Felson, D. T. et al. 2016. Recommendations for the conduct of efficacy trials of treatment devices for osteoarthritis: a report from a working group of the Arthritis Research UK Osteoarthritis and Crystal Diseases Clinical Studies Group. Rheumatology 55(2), pp. 320-326. (10.1093/rheumatology/kev328)
2015
- Eastwood, S. E., John, A., Jones, S. A., Hodgson, H., Mason, D. J., Waddington, R. and Wei, X. 2015. Osteoclastogenesis-related cytokines and peri-prosthetic osteolysis in revision metal-on-metal total hip replacements. Hip International 25(4), pp. 355-360. (10.5301/hipint.5000241)
2014
- Vazquez, M., Evans, B. A. J., Riccardi, D., Evans, S. L., Ralphs, J. R., Dillingham, C. M. and Mason, D. J. 2014. A new method to investigate how mechanical loading of osteocytes controls osteoblasts. Frontiers in Endocrinology 5, article number: 208. (10.3389/fendo.2014.00208)
- Bonnet, C. S., Williams, A. S., Gilbert, S. J., Harvey, A. K., Evans, B. A. and Mason, D. J. 2014. AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Annals of the Rheumatic Diseases 74, pp. 242-251. (10.1136/annrheumdis-2013-203670)
- Gilbert, S. J. et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5, article number: 174. (10.3389/fendo.2014.00174)
- Sanders, R., Mason, D. J., Foy, C. A. and Huggett, J. F. 2014. Considerations for accurate gene expression measurement by reverse transcription quantitative PCR when analysing clinical samples. Analytical and Bioanalytical Chemistry 406(26), pp. 6471-6483. (10.1007/s00216-014-7857-x)
- Bonnet, C., Williams, A. S., Gilbert, S. J., Harvey, A., Evans, B. A. J. and Mason, D. J. 2014. NBQX, a glutamate receptor antagonist, alleviates inflammation, pathology and gait abnormalities in a rat model of inflammatory arthritis. International Journal of Experimental Pathology 95(3), pp. A5-A6. (10.1111/iep.12078)
- Vazquez, M., Evans, B., Evans, S., Ralphs, J., Riccardi, D. and Mason, D. 2014. Development of a novel in vitro 3D osteoblast-osteocyte co-culture model to investigate mechanically-induced signalling. International Journal of Experimental Pathology 95(3), pp. A34-A35. (10.1111/iep.12078)
- Scully, N. E. E., Evans, S. L., Mason, D. J. and Evans, B. A. J. 2014. Development of a novel 3D mineralising culture system to investigate the differentiation of osteoblasts to osteocytes. International Journal of Experimental Pathology 95(3), pp. A29-A29. (10.1111/iep.12078)
- Gilbert, S. J., Meakin, L. B., Mason, D. J., Duance, V. C. and Blain, E. J. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95(3), pp. A11-A12. (10.1111/iep.12078)
- Holt, C. A., Whatling, G. M., Bonnet, C., Brakspear, K., Wilson, C., Williams, R. and Mason, D. J. 2014. Correlating biomechanics and biological signals in subjects undergoing high tibial osteotomy. Presented at: Othopaedic Research Society, New Orleans, LA, USA, 15-18th March 2014.
2013
- Sanders, R., Mason, D. J., Foy, C. A. and Huggett, J. F. 2013. Evaluation of digital PCR for absolute RNA quantification. PLoS ONE 8(9), article number: e75296. (10.1371/journal.pone.0075296)
2012
- Brakspear, K. S. and Mason, D. J. 2012. Glutamate signaling in bone. Frontiers in Endocrinology 3, article number: 97. (10.3389/fendo.2012.00097)
- Bonnet, C., Williams, A. S., Harvey, A., Gilbert, S. J., Moideen, A. N., Nowell, M. A. and Mason, D. J. 2012. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. Osteoporosis International 23, pp. S527-S527.
- Gilbert, S. J., Blain, E. J., Al-Sabah, A., Zhang, Y., Duance, V. C. and Mason, D. J. 2012. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials 23, pp. 41-57.
- Whatling, G. M., Mason, D., Brakspear, K., Roberts, H., Watling, D., Metcalfe, A. and Holt, C. A. 2012. Biomechanical and biological changes following high tibial osteotomy. Presented at: 18th Congress of the European Society of Biomechanics., Lisbon, Portugal, 1-4 July 2012.
2011
- Vazquez, M., Evans, B. A. J., Ralphs, J. R., Riccardi, D. and Mason, D. J. 2011. Bone in vitro 3D osteoblast-osteocyte co-culture model. International Journal of Experimental Pathology 92(6), pp. A18-A18. (10.1111/j.1365-2613.2011.00780.x)
- Parsons, P. et al. 2011. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
- Parsons, P. et al. 2011. Identification of a type IX collagen interaction with fibronectin: a molecular bridge in articular cartilage?. The Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
- Whatling, G. M. et al. 2011. High tibial osteotomy: linking biomechanical and biological changes. Presented at: British Orthopaedic Research Society, Cambridge, 27-29 June 2011.
2010
- Gilbert, S. J., Patel, M., Toumi, H., Duance, V. C. and Mason, D. J. 2010. Knockout of P58(IPK), a known inhibitor of PKR, in mice results in a degenerative phenotype in the knee joint. International Journal of Experimental Pathology 91(2), pp. A34-A34. (10.1111/j.1365-2613.2009.00690.x)
- Mason, D. J., Brakspear, K. S., Wilson, C., Williams, R. and Kotwal, R. S. 2010. Glutamatergic signalling in the osteoarthritic knee. International Journal of Experimental Pathology 91(2), pp. A34-A35. (10.1111/j.1365-2613.2009.00690.x)
- Mason, D. J., Brakspear, K., Wilson, C., Williams, R. and Kotwal, R. 2010. Glutamatergic signals in human arthritis: A link between mechanical, nociceptive and pathological processes. Bone 46, pp. S76. (10.1016/j.bone.2010.01.185)
- Mason, D. J. et al. 2010. Can joint realignment surgery reveal mechanically regulated signals that influence pain and pathology in humans?. Presented at: Annual Meeting of the European Research Society (EORS), Davos, Switzerland, 30 June - 2 July 2010.
2009
- Brakspear, K. S., Parsons, P. and Mason, D. J. 2009. Glutamate transporter inhibitors influence osteoblast gene expression and activity. International Journal of Experimental Pathology 90(2), pp. A107-A108. (10.1111/j.1365-2613.2008.00644.x)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncostatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112. (10.1111/j.1365-2613.2008.00644.x)
- Mason, D. J., Dillingham, C. M., Williams, S. E., Evans, B. A. J., Brakspear, K. S. and Ralphs, J. 2009. Interactions between osteocytes and osteoblasts in a novel 3D co-culture system [Abstract]. International Journal of Experimental Pathology 90(2), pp. A104. (10.1111/j.1365-2613.2008.00644.x)
- Brakspear, K. S., Parsons, P. and Mason, D. J. 2009. Glutamate transporter inhibitors influence osteoblast gene expression and activity [Abstract]. International Journal of Experimental Pathology 90(2), pp. A107-A108. (10.1111/j.1365-2613.2009.00644.x)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncastatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112.
2008
- Gilbert, S. J., Blain, E. J., Duance, V. C. and Mason, D. J. 2008. Sphingomyelinase decreases type II collagen expression in bovine articular chondrocytes via the ERK signalling pathway. Arthritis and Rheumatism 58(1), pp. 209-220. (10.1002/art.23172)
- Mason, D., Dillingham, C. M., Evans, B. A., Brakspear, K. S. and Ralphs, J. R. 2008. A 3D culture system to investigate osteocyte control of osteoblasts. Bone 42(Suppl), pp. S26-S27. (10.1016/j.bone.2007.12.033)
2006
- Gilbert, S. J., Blain, E. J., Jones, P., Duance, V. C. and Mason, D. J. 2006. Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis research & therapy 8(4), article number: R89. (10.1186/ar1961)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2006. Protein kinase R: A novel mediator of articular cartilage degradation in arthritis. Current Rheumatology Reviews 2(1), pp. 9-21. (10.2174/157339706775697026)
2004
- Mason, D. J. 2004. Glutamate signalling and its potential application to tissue engineering of bone. European Cells and Materials 7, pp. 12-26.
- Mason, D. J. 2004. The role of glutamate transporters in bone cell signalling. Journal of Musculoskeletal Neuronal Interactions 4(2), pp. 128-131.
2003
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2003. Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?. Arthritis Research & Therapy 6(1), pp. R46-R55. (10.1186/ar1024)
- Blain, E. J., Mason, D. J. and Duance, V. C. 2003. The effect of cyclical compressive loading on gene expression in articular cartilage. Biorheology 40(1-3), pp. 111-117.
- Mason, D. J. and Huggett, J. F. 2003. Elucidation of mechanically-regulated signalling pathways in bone and their application to bone tissue engineering. European Cells and Materials 5(Supp 2), pp. 26-27.
2002
- Huggett, J. F., Mustafa, A., O'Neal, L. and Mason, D. J. 2002. The glutamate transporter GLAST-1 (EAAT-1) is expressed in the plasma membrane of osteocytes and is responsive to extracellular glutamate concentration.. Biochemical Society Transactions 30(6), pp. 890-893. (10.1042/BST0300890)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocytes. Biochemical Society Transactions 30(6), pp. 886-889. (10.1042/BST0300886)
- Blain, E. J., Mason, D. J. and Duance, V. C. 2002. The effect of thymosin β4 on articular cartilage chondrocyte matrix metalloproteinase expression. Biochemical Society Transactions 30(6), pp. 879-882. (10.1042/BST0300879)
- Mason, D. 2002. Glutamate transporters in bone. Journal of Musculoskeletal and Neuronal Interactions 2(5), pp. 406-414.
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocyte. Biochemical Society Transactions 30, pp. 886-889. (10.1042/bst0300886)
2001
- Blain, E. J., Gilbert, S. J., Wardale, R. J., Capper, S. J., Mason, D. J. and Duance, V. C. 2001. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Archives of biochemistry and biophysics 396(1), pp. 49-55. (10.1006/abbi.2001.2575)
- Skerry, T., Genever, P., Taylor, A., Dobson, K., Mason, D. J. and Suva, L. 2001. Absence of evidence is not evidence of absence: The shortcomings of the GLAST knockout mouse [2] [Abstract]. Journal of Bone and Mineral Research 16(9), pp. 1729-1730. (10.1359/jbmr.2001.16.9.1729)
- Skerry, T., Genever, P., Taylor, A., Dobson, K., Mason, D. J. and Suva, L. 2001. Absence of evidence is not evidence of absence; The shortcomings of the GLAST knockout mouse [Letter]. Journal of Bone and Mineral Research 16(9), pp. 1729-1730. (10.1359/jbmr.2001.16.9.1729)
2000
- Huggett, J., Mason, D. J. and Vaughan-Thomas, A. 2000. The open reading frame of the Na+-dependent glutamate transporter GLAST-1 is expressed in bone and a splice variant of this molecule is expressed in bone and brain. FEBS Letters 485(1), pp. 13-18. (10.1016/S0014-5793(00)02175-X)
1997
- Mason, D., Suva, L. J., Genever, P. G., Patton, A. J., Steuckle, S., Hillam, R. A. and Skerry, T. M. 1997. Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents?. Bone 20(3), pp. 199-205.
1996
- Mason, D. J., Hillam, R. and Skerry, T. 1996. Constitutive in vivo mRNA expression by osteocytes of β-actin, osteocalcin, connexin-43, IGF-I, c-fos and c-jun, but not TNF- nor tartrate-resistant acid phosphatase. Journal of Bone and Mineral Research 11(3), pp. 350-357. (10.1002/jbmr.5650110308)
1995
- Mason, D. J., RK, B. and P, G. 1995. An unusual mitochondrial DNA polymorphism in the Chorthippus biguttulus species group (Orthoptera:Acrididae). Molecular Ecology 4(1), pp. 121-126. (10.1111/j.1365-294X.1995.tb00199.x)
Articles
- Jones, R., Gilbert, S. J., Christofides, S. R. and Mason, D. J. 2024. Osteocytes contribute to sex-specific differences in osteoarthritic pain. Frontiers in Endocrinology 15, article number: 1480274. (10.3389/fendo.2024.1480274)
- Kalsoum, R. et al. 2024. A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury.. Bone & Joint Research 13(9), pp. 513-524. (10.1302/2046-3758.139.BJR-2024-0109)
- Gilbert, S. J., Jones, R., Egan, B. J., Bonnet, C. S., Evans, S. L. and Mason, D. J. 2024. Investigating mechanical and inflammatory pathological mechanisms in osteoarthritis using MSC-derived osteocyte-like cells in 3D. Frontiers in Endocrinology 15, article number: 1359052. (10.3389/fendo.2024.1359052)
- Whittaker, J. L. et al. 2024. Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop. Osteoarthritis and Cartilage Open 6(2), article number: 100449. (10.1016/j.ocarto.2024.100449)
- Hamilton, R., Garcia, A. A., Bowd, J., Hamilton, D., Mason, D., Elliott, M. and Holt, C. 2024. Utilising electrodermal activity sensor signals to quantify nociceptive response during movement activities. BMC Research Notes 17, article number: 36. (10.1186/s13104-024-06689-9)
- Gilbert, S. J., Blain, E. J. and Mason, D. J. 2022. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms. Biochemistry and Biophysics Reports 32, article number: 101323. (10.1016/j.bbrep.2022.101323)
- Paskins, Z. et al. 2022. Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method. The Lancet Rheumatology 4(9), pp. 635-645. (10.1016/S2665-9913(22)00136-9)
- Mason, D., Englund, M. and Watt, F. E. 2021. Prevention of posttraumatic osteoarthritis at the time of injury: Where are we now, and where are we going?. Journal of Orthopaedic Research 39(6), pp. 1152-1163. (10.1002/jor.24982)
- Bonnet, C. S., Gilbert, S. J., Blain, E. J., Williams, A. S. and Mason, D. J. 2020. AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis. JCI Insight 5(13), article number: e134055. (10.1172/jci.insight.134055)
- Khatib, N., Biggs, P., Wilson, C., Williams, R., Mason, D. and Holt, C. 2019. Dynamic medial knee overloading influences inflammation and bone remodeling in the degenerative knee [Abstract]. Osteoarthritis and Cartilage 27(S1), pp. S44., article number: 29. (10.1016/j.joca.2019.02.063)
- Watt, F. E. et al. 2019. Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury. Osteoarthritis and Cartilage 27(1), pp. 23-33. (10.1016/j.joca.2018.08.001)
- Gilbert, S. J., Bonnet, C. S., Stadnik, P., Duance, V. C., Mason, D. J. and Blain, E. J. 2018. Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis. Journal of Orthopaedic Research 36(8), pp. 2118-2127. (10.1002/jor.23872)
- Jähn, K., Mason, D., Ralphs, J., Evans, B., Archer, C., Richards, R. G. and Stoddart, M. 2018. Phenotype and viability of MLO-Y4 cells Is maintained by TGFβ3 in a serum-dependent manner within a 3D-co-culture with MG-63 cells. International Journal of Molecular Sciences 19(7), article number: 1932. (10.3390/ijms19071932)
- Sanders, R., Bustin, S., Huggett, J. and Mason, D. 2018. Improving the standardization of mRNA measurement by RT-qPCR. Biomolecular Detection and Quantification 15, pp. 13-17. (10.1016/j.bdq.2018.03.001)
- Khatib, N., Papageorgiou, A., Vazquez, M., Flintoft, F., Holt, C. and Mason, D. 2018. How does an AMPA/KA receptor antagonist affect the metabolic profile of a bone co-culture loading model? an NMR spectroscopy approach [Abstract]. International Journal of Experimental Pathology 98(1), pp. A21. (10.1111/iep.12218)
- Holt, C. A. et al. 2016. Biological changes in tibial subchondral bone following high tibial osteotomy. Osteoarthritis and Cartilage 24(S1), pp. S511-S511. (10.1016/j.joca.2016.01.935)
- Felson, D. T. et al. 2016. Recommendations for the conduct of efficacy trials of treatment devices for osteoarthritis: a report from a working group of the Arthritis Research UK Osteoarthritis and Crystal Diseases Clinical Studies Group. Rheumatology 55(2), pp. 320-326. (10.1093/rheumatology/kev328)
- Eastwood, S. E., John, A., Jones, S. A., Hodgson, H., Mason, D. J., Waddington, R. and Wei, X. 2015. Osteoclastogenesis-related cytokines and peri-prosthetic osteolysis in revision metal-on-metal total hip replacements. Hip International 25(4), pp. 355-360. (10.5301/hipint.5000241)
- Vazquez, M., Evans, B. A. J., Riccardi, D., Evans, S. L., Ralphs, J. R., Dillingham, C. M. and Mason, D. J. 2014. A new method to investigate how mechanical loading of osteocytes controls osteoblasts. Frontiers in Endocrinology 5, article number: 208. (10.3389/fendo.2014.00208)
- Bonnet, C. S., Williams, A. S., Gilbert, S. J., Harvey, A. K., Evans, B. A. and Mason, D. J. 2014. AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Annals of the Rheumatic Diseases 74, pp. 242-251. (10.1136/annrheumdis-2013-203670)
- Gilbert, S. J. et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5, article number: 174. (10.3389/fendo.2014.00174)
- Sanders, R., Mason, D. J., Foy, C. A. and Huggett, J. F. 2014. Considerations for accurate gene expression measurement by reverse transcription quantitative PCR when analysing clinical samples. Analytical and Bioanalytical Chemistry 406(26), pp. 6471-6483. (10.1007/s00216-014-7857-x)
- Bonnet, C., Williams, A. S., Gilbert, S. J., Harvey, A., Evans, B. A. J. and Mason, D. J. 2014. NBQX, a glutamate receptor antagonist, alleviates inflammation, pathology and gait abnormalities in a rat model of inflammatory arthritis. International Journal of Experimental Pathology 95(3), pp. A5-A6. (10.1111/iep.12078)
- Vazquez, M., Evans, B., Evans, S., Ralphs, J., Riccardi, D. and Mason, D. 2014. Development of a novel in vitro 3D osteoblast-osteocyte co-culture model to investigate mechanically-induced signalling. International Journal of Experimental Pathology 95(3), pp. A34-A35. (10.1111/iep.12078)
- Scully, N. E. E., Evans, S. L., Mason, D. J. and Evans, B. A. J. 2014. Development of a novel 3D mineralising culture system to investigate the differentiation of osteoblasts to osteocytes. International Journal of Experimental Pathology 95(3), pp. A29-A29. (10.1111/iep.12078)
- Gilbert, S. J., Meakin, L. B., Mason, D. J., Duance, V. C. and Blain, E. J. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95(3), pp. A11-A12. (10.1111/iep.12078)
- Sanders, R., Mason, D. J., Foy, C. A. and Huggett, J. F. 2013. Evaluation of digital PCR for absolute RNA quantification. PLoS ONE 8(9), article number: e75296. (10.1371/journal.pone.0075296)
- Brakspear, K. S. and Mason, D. J. 2012. Glutamate signaling in bone. Frontiers in Endocrinology 3, article number: 97. (10.3389/fendo.2012.00097)
- Bonnet, C., Williams, A. S., Harvey, A., Gilbert, S. J., Moideen, A. N., Nowell, M. A. and Mason, D. J. 2012. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. Osteoporosis International 23, pp. S527-S527.
- Gilbert, S. J., Blain, E. J., Al-Sabah, A., Zhang, Y., Duance, V. C. and Mason, D. J. 2012. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials 23, pp. 41-57.
- Vazquez, M., Evans, B. A. J., Ralphs, J. R., Riccardi, D. and Mason, D. J. 2011. Bone in vitro 3D osteoblast-osteocyte co-culture model. International Journal of Experimental Pathology 92(6), pp. A18-A18. (10.1111/j.1365-2613.2011.00780.x)
- Parsons, P. et al. 2011. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
- Parsons, P. et al. 2011. Identification of a type IX collagen interaction with fibronectin: a molecular bridge in articular cartilage?. The Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
- Gilbert, S. J., Patel, M., Toumi, H., Duance, V. C. and Mason, D. J. 2010. Knockout of P58(IPK), a known inhibitor of PKR, in mice results in a degenerative phenotype in the knee joint. International Journal of Experimental Pathology 91(2), pp. A34-A34. (10.1111/j.1365-2613.2009.00690.x)
- Mason, D. J., Brakspear, K. S., Wilson, C., Williams, R. and Kotwal, R. S. 2010. Glutamatergic signalling in the osteoarthritic knee. International Journal of Experimental Pathology 91(2), pp. A34-A35. (10.1111/j.1365-2613.2009.00690.x)
- Mason, D. J., Brakspear, K., Wilson, C., Williams, R. and Kotwal, R. 2010. Glutamatergic signals in human arthritis: A link between mechanical, nociceptive and pathological processes. Bone 46, pp. S76. (10.1016/j.bone.2010.01.185)
- Brakspear, K. S., Parsons, P. and Mason, D. J. 2009. Glutamate transporter inhibitors influence osteoblast gene expression and activity. International Journal of Experimental Pathology 90(2), pp. A107-A108. (10.1111/j.1365-2613.2008.00644.x)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncostatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112. (10.1111/j.1365-2613.2008.00644.x)
- Mason, D. J., Dillingham, C. M., Williams, S. E., Evans, B. A. J., Brakspear, K. S. and Ralphs, J. 2009. Interactions between osteocytes and osteoblasts in a novel 3D co-culture system [Abstract]. International Journal of Experimental Pathology 90(2), pp. A104. (10.1111/j.1365-2613.2008.00644.x)
- Brakspear, K. S., Parsons, P. and Mason, D. J. 2009. Glutamate transporter inhibitors influence osteoblast gene expression and activity [Abstract]. International Journal of Experimental Pathology 90(2), pp. A107-A108. (10.1111/j.1365-2613.2009.00644.x)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncastatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112.
- Gilbert, S. J., Blain, E. J., Duance, V. C. and Mason, D. J. 2008. Sphingomyelinase decreases type II collagen expression in bovine articular chondrocytes via the ERK signalling pathway. Arthritis and Rheumatism 58(1), pp. 209-220. (10.1002/art.23172)
- Mason, D., Dillingham, C. M., Evans, B. A., Brakspear, K. S. and Ralphs, J. R. 2008. A 3D culture system to investigate osteocyte control of osteoblasts. Bone 42(Suppl), pp. S26-S27. (10.1016/j.bone.2007.12.033)
- Gilbert, S. J., Blain, E. J., Jones, P., Duance, V. C. and Mason, D. J. 2006. Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis research & therapy 8(4), article number: R89. (10.1186/ar1961)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2006. Protein kinase R: A novel mediator of articular cartilage degradation in arthritis. Current Rheumatology Reviews 2(1), pp. 9-21. (10.2174/157339706775697026)
- Mason, D. J. 2004. Glutamate signalling and its potential application to tissue engineering of bone. European Cells and Materials 7, pp. 12-26.
- Mason, D. J. 2004. The role of glutamate transporters in bone cell signalling. Journal of Musculoskeletal Neuronal Interactions 4(2), pp. 128-131.
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2003. Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?. Arthritis Research & Therapy 6(1), pp. R46-R55. (10.1186/ar1024)
- Blain, E. J., Mason, D. J. and Duance, V. C. 2003. The effect of cyclical compressive loading on gene expression in articular cartilage. Biorheology 40(1-3), pp. 111-117.
- Mason, D. J. and Huggett, J. F. 2003. Elucidation of mechanically-regulated signalling pathways in bone and their application to bone tissue engineering. European Cells and Materials 5(Supp 2), pp. 26-27.
- Huggett, J. F., Mustafa, A., O'Neal, L. and Mason, D. J. 2002. The glutamate transporter GLAST-1 (EAAT-1) is expressed in the plasma membrane of osteocytes and is responsive to extracellular glutamate concentration.. Biochemical Society Transactions 30(6), pp. 890-893. (10.1042/BST0300890)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocytes. Biochemical Society Transactions 30(6), pp. 886-889. (10.1042/BST0300886)
- Blain, E. J., Mason, D. J. and Duance, V. C. 2002. The effect of thymosin β4 on articular cartilage chondrocyte matrix metalloproteinase expression. Biochemical Society Transactions 30(6), pp. 879-882. (10.1042/BST0300879)
- Mason, D. 2002. Glutamate transporters in bone. Journal of Musculoskeletal and Neuronal Interactions 2(5), pp. 406-414.
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocyte. Biochemical Society Transactions 30, pp. 886-889. (10.1042/bst0300886)
- Blain, E. J., Gilbert, S. J., Wardale, R. J., Capper, S. J., Mason, D. J. and Duance, V. C. 2001. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Archives of biochemistry and biophysics 396(1), pp. 49-55. (10.1006/abbi.2001.2575)
- Skerry, T., Genever, P., Taylor, A., Dobson, K., Mason, D. J. and Suva, L. 2001. Absence of evidence is not evidence of absence: The shortcomings of the GLAST knockout mouse [2] [Abstract]. Journal of Bone and Mineral Research 16(9), pp. 1729-1730. (10.1359/jbmr.2001.16.9.1729)
- Skerry, T., Genever, P., Taylor, A., Dobson, K., Mason, D. J. and Suva, L. 2001. Absence of evidence is not evidence of absence; The shortcomings of the GLAST knockout mouse [Letter]. Journal of Bone and Mineral Research 16(9), pp. 1729-1730. (10.1359/jbmr.2001.16.9.1729)
- Huggett, J., Mason, D. J. and Vaughan-Thomas, A. 2000. The open reading frame of the Na+-dependent glutamate transporter GLAST-1 is expressed in bone and a splice variant of this molecule is expressed in bone and brain. FEBS Letters 485(1), pp. 13-18. (10.1016/S0014-5793(00)02175-X)
- Mason, D., Suva, L. J., Genever, P. G., Patton, A. J., Steuckle, S., Hillam, R. A. and Skerry, T. M. 1997. Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents?. Bone 20(3), pp. 199-205.
- Mason, D. J., Hillam, R. and Skerry, T. 1996. Constitutive in vivo mRNA expression by osteocytes of β-actin, osteocalcin, connexin-43, IGF-I, c-fos and c-jun, but not TNF- nor tartrate-resistant acid phosphatase. Journal of Bone and Mineral Research 11(3), pp. 350-357. (10.1002/jbmr.5650110308)
- Mason, D. J., RK, B. and P, G. 1995. An unusual mitochondrial DNA polymorphism in the Chorthippus biguttulus species group (Orthoptera:Acrididae). Molecular Ecology 4(1), pp. 121-126. (10.1111/j.1365-294X.1995.tb00199.x)
Conferences
- Hamilton, R. et al. 2023. Measuring osteoarthritis knee nociception using physiological and movement response and a defined thermal stimulus: A proof-of-concept study.. Presented at: The International Combined Orthopaedic Research Societies (ICORS), World Congress of Orthopaedic Research, Edinburgh, UK, 7-9 September 2022Orthopaedic Proceedings, Vol. 105-B,. pp. 20-20., (10.1302/1358-992X.2023.8.020)
- Hamilton, R., Holt, C., Jones, R., Shillabeer, D., Sparkes, V. and Mason, D. 2021. Measuring nociception in knee osteoarthritis using physiological and movement responses: a proof-of-concept study. Presented at: British Orthopaedic Research Society, Cardiff, UK, 13-14 September 2021.
- Simonovic, J., Holt, C. and Mason, D. 2019. Semantic insight and behaviour of the computational bone cell population models. Presented at: 25th Congress of the European Society of Biomechanics (ESB 2019), Vienna, Austria, 7-10 July 2019. pp. -.
- Holt, C. A., Whatling, G. M., Bonnet, C., Brakspear, K., Wilson, C., Williams, R. and Mason, D. J. 2014. Correlating biomechanics and biological signals in subjects undergoing high tibial osteotomy. Presented at: Othopaedic Research Society, New Orleans, LA, USA, 15-18th March 2014.
- Whatling, G. M., Mason, D., Brakspear, K., Roberts, H., Watling, D., Metcalfe, A. and Holt, C. A. 2012. Biomechanical and biological changes following high tibial osteotomy. Presented at: 18th Congress of the European Society of Biomechanics., Lisbon, Portugal, 1-4 July 2012.
- Whatling, G. M. et al. 2011. High tibial osteotomy: linking biomechanical and biological changes. Presented at: British Orthopaedic Research Society, Cambridge, 27-29 June 2011.
- Mason, D. J. et al. 2010. Can joint realignment surgery reveal mechanically regulated signals that influence pain and pathology in humans?. Presented at: Annual Meeting of the European Research Society (EORS), Davos, Switzerland, 30 June - 2 July 2010.
Ymchwil
Rwy'n fiolegydd moleciwlaidd a chelloedd ym maes clefydau cyhyrysgerbydol. Mae fy ymchwil wedi datgelu bod rhyddhau glutamate yn cael ei reoleiddio mewn arthritis, bod derbynyddion glutamate yn gweithredu mewn meinweoedd cyhyrysgerbydol a bod eu hatal yn amddiffyn rhag osteoarthritis mewn modelau anifeiliaid. Mae hyn yn arwain tuag at therapïau newydd ar gyfer osteoarthritis gyda patentau a roddwyd. Fe wnaethom greu modelau celloedd, anifeiliaid a dynol i sut mae llwyth mecanyddol yn dylanwadu ar osteoarthritis, dirywiad a phoen. Mae ein modelau esgyrn 3D yn cael eu datblygu fel offer sgrinio cyffuriau, i ddatgelu genomeg swyddogaethol sy'n sail i gysylltiadau eang genom ag osteoarthritis ac i ymchwilio i ryngweithiadau esgyrn-nerf a phoen. Mae fy mhenderfyniad i bontio'r bwlch trosiadol rhwng darganfyddiadau gwyddoniaeth sylfaenol a meddygaeth glinigol wedi ymestyn fy ymchwil i weithdai a phapurau rhyngwladol ar ddylunio treialon ar gyfer osteoarthritis ôl-drawmatig.
Ymchwil gyfredol
- Canolfan Ymchwil Biomecaneg a Biobeirianneg CoPI yn erbyn Arthritis (2016-28) £2.27M
- PI Model nerf synhwyraidd esgyrn dynol i ymchwilio i boen sy'n deillio o esgyrn. NC3Rs (2023-26) £633,628
- PI Nodi mesurau gwrthrychol o boen rhyw-benodol mewn bodau dynol y gellir eu defnyddio'n ddiagnostig i dargedu triniaeth. Orthopaedics Research UK (2023-24) £47,00
- CoI Osteoarthritis nad yw'n radiograffig: astudiaeth mynegiant metabolig, biocemegol ac RNA mewn cŵn â chlefyd / rhwyg ligament cruciate cranial. (2024-26) BVOA £9948
Prosiectau diweddar
- PI Ymchwilio i dderbynyddion glutamad mewn osteoarthritis: Diwydiant (Ionawr-Hydref 2023) £172,000
- PI A allai triniaeth gwrthlidiol yn ailadeiladu ACL wella canlyniadau biolegol, swyddogaethol a chlinigol? Gwybodaeth, Economi Ysgoloriaethau Sgiliau 2 Prosiect Dwyrain Cymru (2020-23) £80,385
- PI Cyfieithu gwrthwynebwyr derbynyddion glutamad i osteoarthritis milfeddygol. Llywodraeth Cymru Arloesi i Bawb a Knoell Animal Health Ltd (2022-23) £10,000 PI Ymchwiliad peilot i fynegiant derbynnydd glutamad mewn osteoarthritis. Orphelion (2021-22) £27,452
- PI - Ymchwilio i dderbynyddion glutamad mewn osteoarthritis: astudiaeth beilot a ariennir gan y diwydiant (Ebrill-Medi 2022) £71,271PI Ffactorau biolegol, clinigol a biomecanyddol sy'n effeithio ar Lawfeddygaeth Osteotomi Tibial Uchel. Alison Kinghorn, Rheolwr Gyfarwyddwr prosiect (2018-2020) Yn erbyn Arthritis a Chanolfan Orthopedig Caerdydd a'r Fro £40,000
- CoI gyda Joel Alves fel arweinydd clinigol. Meintioli biofarcwyr llidiol a chynnar OA mewn clefyd ligament cruciate cranial cŵn. Ymddiriedolaeth Elusennol Petplan (2021-2022) £9860CoI Mesurau nociceptive osteoarthritis. EPSRC (Ebrill - Awst 2022) £42805.
- CoI Modelu Mechanotransduction o'r gilfach esgyrn sy'n gyrru canser metastatig y prostad. Ymchwil Canser Cymru (2019-21) £147,301
- CoI Rôl maint, siâp a strwythur esgyrn a chymalau, wrth esbonio clefydau cyhyrysgerbydol cyffredin. Gwobr Cydweithredu Ymddiriedolaeth Wellcome (2018-23) £1,565,599
- PI Ail-bwrpasu AMP397 i atal osteoarthritis ôl-drawmatig. Yn erbyn Arthritis (2019-22) £49,064
- CoI Glutamate receptor antagonists as a novel approach to treat cruciate ligament disease in dogs – an observational study. Cymdeithas Orthopedig Milfeddygol Prydain (2017-19) £4,582
Cydweithrediadau Cyfredol
Arloesi Ysbyty Diwydiant , Novartis, Academydd Orphelion Yr Athro Tobias (Bryste), Mr Wilson (Ymddiriedolaeth GIG Caerdydd a'r Fro), Dr Fiona Watt (Imperial), Yr Athro Karina Wright (Keele), Mr Stephen McDonnell (Caergrawnt). Caerdydd Yr Athro Cathy Holt (Peirianneg), Dr David Williams (Peirianneg), Dr Emma Blain (Biowyddorau), Yr Athro Val Sparkes (Gofal Iechyd).
Aelodau'r grŵp ymchwil presennol
Cymdeithion ymchwil ôl-ddoethurol
- Dr Sophie Gilbert
- Dr Ryan Jones
- Dr Paul White
Myfyrwyr PhD
- Joel Alves
Addysgu
I am an enthusiastic and effective lecturer contributing to a range of teaching activities (tutorials, lectures, workshops, practical, projects) across various levels and Degree Schemes (BSc: Biomolecular, Biomedical, Medical, Dental; MSc). I adapt my methods according to student feedback, peer assessment and student achievement. As Level 1 Co-ordinator for Biochemistry Degree Schemes, Molecular Biology Degree Scheme Co-ordinator and Final Year Tutor for all Biomolecular Schemes I have made major contributions to management, teaching, course design and administration.
I currently Lead the final year Contemporary Topics in Disease Module, where cutting edge research in the School of Biosciences demonstrates how research can reveal pathological mechanisms and identify and test new treatments across a wide range of diseases.
Bywgraffiad
After my BSc in Zoology and Genetics (1986) and my PhD in Evolutionary Genetics (1991) in Cardiff, I worked briefly in Medical Genetics at the University Hospital of Wales before moving to Bristol University. My research in Bristol revealed osteocyte gene expression in vivo and implicated glutamatergic signalling in mechanically-induced bone formation. Since my appointment as Lecturer in Cardiff University in 1996 (Senior Lecturer in 2009, Reader in 2012), I have investigated the role of glutamate transporters in bone, revealed a pathological role for glutamate in arthritis, and identified new pathways of cytokine- and mechanically- induced cartilage degradation involving PKR, ceramide and the cytoskeleton. I have secured over £12M of research funding for 30 projects. I co-ordinated Cardiff’s bid for the Arthritis Research UK-funded Centre of Excellence in Biomechanics and Bioengineering, where I act as a manager, and as the Biomechanics, Inflammation and Pain Team Leader. I have served on the Bone Research Society and the British Orthopaedic Research Committees. I have supervised 11 PhD/MD students and teach undergraduate students, co-ordinating the Molecular Biology Degree Scheme in Cardiff and acting as final year tutor for all Biomolecular Degree Schemes. I regularly contribute to public engagement activities with school children, patients and fundraisers.
Meysydd goruchwyliaeth
I am interested in supervising students in the areas of:
- developing new preventative treatments for osteoarthritis
- early diagnosis of osteoarthritis
- cell models for drug screening
Contact Details
+44 29208 74561
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX