![Deborah Mason BSc (Cardiff), PhD (Cardiff) FIOR](https://profiles-cardiff.imgix.net/attachments/1125?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Deborah Mason
(hi/ei)
BSc (Cardiff), PhD (Cardiff) FIOR
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Deborah Mason
Athro, Ysgol y Biowyddorau; Cyfarwyddwr Ymchwil Cyn-Glinigol
Ysgol y Biowyddorau
Trosolwg
Rwy'n Gyd-gyfarwyddwr Canolfan Ragoriaeth Biomecaneg a Biobeirianneg Arthritis UK ym Mhrifysgol Caerdydd, lle rwy'n arwain y Rhaglen Ymchwil Cyn-glinigol sy'n ymchwilio i'r rhyngweithio rhwng biomecaneg a bioleg mewn meinweoedd ar y cyd. Rwyf wedi sefydlu platfform o fodelau celloedd, anifeiliaid a dynol i ymchwilio i sut mae llwyth mecanyddol yn rheoleiddio patholeg a phoen ar y cyd. Mae fy ymchwil yn egluro mecanweithiau signalau newydd sy'n rheoleiddio trosiant esgyrn a cartilag, i ddarparu targedau therapiwtig a diagnostig ar gyfer clefydau cyhyrysgerbydol. Mae hyn wedi arwain at ddarganfod signalau glutamatergig swyddogaethol mewn meinweoedd ar y cyd, ac wedi datgelu llwybrau newydd sy'n cyfryngu diraddiad cymalau a achosir gan cytokinau a mecanyddol a sefydlu sut mae hyn yn dylanwadu ar boen. Mae fy ymchwil yn canolbwyntio ar gyfieithu gwrthwynebwyr derbynyddion glutamad fel triniaeth ar gyfer osteoarthritis, nodi biomarcwyr wedi'u rheoleiddio'n fecanyddol a datblygu mimetig ar y cyd ar gyfer sgrinio cyffuriau.
Rwyf wedi arwain dros 40 o brosiectau ymchwil (a ariennwyd yn ddiweddar gan NIHR, NC3Rs, Arthritis UK, Industry, Orthopaedics Research UK, Wellcome Trust, EPSRC, Versus Arthritis,), dyfeisio patentau a chydweithio ag academyddion, y GIG a chlinigwyr milfeddygol a diwydiant. Rwy'n Gymrawd Ymchwil Orthopedig Ryngwladol Coleg Cymrodyr Rhyngwladol ICORS i gydnabod statws proffesiynol rhagorol a chyflawniadau uchel ym maes ymchwil orthopedig.
Rolau
Caerdydd
- Cyd-gyfarwyddwr, Canolfan Ymchwil Biomechneg a Biopheirianneg Arthritis UK
- Arweinydd Modiwl BI3351 Pynciau Cyfoes mewn Clefydau
- Bwrdd Rheoli Innovations@sbarc Caerdydd
Cenedlaethol
- Cyn-Lywydd a Chadeirydd Ymddiriedolwyr, Cymdeithas Ymchwil Orthopedig Prydain
- Arweinydd Thema Drosiannol, Grŵp Cynghori Ymchwil Cyhyrysgerbydol, Versus Arthritis
- Arweinydd is-thema 'Treialon mewn poblogaethau mewn perygl' yn Ffrwd Waith Cyflyrau Cyhyrysgerbydol Cyffredin NIHR Translational Research Collaboration
Rhyngwladol
- Tasglu cydraddoldeb, amrywiaeth a chynhwysiant y Cymdeithasau Ymchwil Orthopedig Cyfunol Rhyngwladol
- Cymrawd Ymchwil Orthopedig Ryngwladol
Oes gennych chi ddiddordeb mewn ymuno â'm labordy fel myfyriwr ôl-raddedig hunan-ariannu neu ôl-ddoethurwriaeth/cymrawd? Cysylltwch â mi drwy e-bost.
Cyhoeddiad
2026
- Rix, L. et al., 2026. A thematic narrative review of osteoarthritis risk factors across the female life course. International Journal of Molecular Sciences 27 (18) 8083. (10.3390/ijms27188083)
- Jones, R. , Gilbert, S. and Mason, D. 2026. A predictive model for the investigation of osteoarthritic pain [Abstract]. Osteoarthritis and Cartilage 34 (S), pp.S61. (10.1016/j.joca.2026.01.058)
- Jones, R. et al. 2026. Sex based differences in IPSC derived nociceptor responses to osteoarthritic synovial fluid [Abstract]. Osteoarthritis and Cartilage 34 (S), pp.S370-S371. (10.1016/j.joca.2026.01.534)
- Jones, R. et al. 2026. A comparison of IPSC derived nociceptors in modelling osteoarthritic pain [Abstract]. Osteoarthritis and Cartilage 34 (Supp), pp.S369-S370. (10.1016/j.joca.2026.01.532)
2024
- Jones, R. et al. 2024. Osteocytes contribute to sex-specific differences in osteoarthritic pain. Frontiers in Endocrinology 15 1480274. (10.3389/fendo.2024.1480274)
- Kalsoum, R. et al., 2024. A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury.. Bone & Joint Research 13 (9), pp.513-524. (10.1302/2046-3758.139.BJR-2024-0109)
- Gilbert, S. J. et al. 2024. Investigating mechanical and inflammatory pathological mechanisms in osteoarthritis using MSC-derived osteocyte-like cells in 3D. Frontiers in Endocrinology 15 1359052. (10.3389/fendo.2024.1359052)
- Whittaker, J. L. et al., 2024. Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop. Osteoarthritis and Cartilage Open 6 (2) 100449. (10.1016/j.ocarto.2024.100449)
- Hamilton, R. et al. 2024. Utilising electrodermal activity sensor signals to quantify nociceptive response during movement activities. BMC Research Notes 17 36. (10.1186/s13104-024-06689-9)
2023
- Hamilton, R. et al. 2023. Measuring osteoarthritis knee nociception using physiological and movement response and a defined thermal stimulus: A proof-of-concept study.. Presented at: The International Combined Orthopaedic Research Societies (ICORS), World Congress of Orthopaedic Research Edinburgh, UK 7-9 September 2022. Orthopaedic Proceedings. Vol. 105-B,., pp.20-20. (10.1302/1358-992X.2023.8.020)
2022
- Gilbert, S. J. , Blain, E. J. and Mason, D. J. 2022. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms. Biochemistry and Biophysics Reports 32 101323. (10.1016/j.bbrep.2022.101323)
- Paskins, Z. et al., 2022. Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method. The Lancet Rheumatology 4 (9), pp.635-645. (10.1016/S2665-9913(22)00136-9)
2021
- Hamilton, R. et al. 2021. Measuring nociception in knee osteoarthritis using physiological and movement responses: a proof-of-concept study. Presented at: British Orthopaedic Research Society Cardiff, UK 13-14 September 2021.
- Mason, D. , Englund, M. and Watt, F. E. 2021. Prevention of posttraumatic osteoarthritis at the time of injury: Where are we now, and where are we going?. Journal of Orthopaedic Research 39 (6), pp.1152-1163. (10.1002/jor.24982)
2020
- Bonnet, C. S. et al. 2020. AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis. JCI Insight 5 (13) e134055. (10.1172/jci.insight.134055)
2019
- Khatib, N. et al. 2019. Dynamic medial knee overloading influences inflammation and bone remodeling in the degenerative knee [Abstract]. Osteoarthritis and Cartilage 27 (S1), pp.S44. 29. (10.1016/j.joca.2019.02.063)
- Simonovic, J. , Holt, C. and Mason, D. 2019. Semantic insight and behaviour of the computational bone cell population models. Presented at: 25th Congress of the European Society of Biomechanics (ESB 2019) Vienna, Austria 7-10 July 2019. , pp.-.
- Watt, F. E. et al., 2019. Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury. Osteoarthritis and Cartilage 27 (1), pp.23-33. (10.1016/j.joca.2018.08.001)
2018
- Gilbert, S. J. et al. 2018. Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis. Journal of Orthopaedic Research 36 (8), pp.2118-2127. (10.1002/jor.23872)
- Jähn, K. et al., 2018. Phenotype and viability of MLO-Y4 cells Is maintained by TGFβ3 in a serum-dependent manner within a 3D-co-culture with MG-63 cells. International Journal of Molecular Sciences 19 (7) 1932. (10.3390/ijms19071932)
- Sanders, R. et al., 2018. Improving the standardization of mRNA measurement by RT-qPCR. Biomolecular Detection and Quantification 15 , pp.13-17. (10.1016/j.bdq.2018.03.001)
- Khatib, N. et al. 2018. How does an AMPA/KA receptor antagonist affect the metabolic profile of a bone co-culture loading model? an NMR spectroscopy approach [Abstract]. International Journal of Experimental Pathology 98 (1), pp.A21. (10.1111/iep.12218)
2016
- Holt, C. A. et al. 2016. Biological changes in tibial subchondral bone following high tibial osteotomy. Osteoarthritis and Cartilage 24 (S1), pp.S511-S511. (10.1016/j.joca.2016.01.935)
- Felson, D. T. et al., 2016. Recommendations for the conduct of efficacy trials of treatment devices for osteoarthritis: a report from a working group of the Arthritis Research UK Osteoarthritis and Crystal Diseases Clinical Studies Group. Rheumatology 55 (2), pp.320-326. (10.1093/rheumatology/kev328)
2015
- Eastwood, S. E. et al., 2015. Osteoclastogenesis-related cytokines and peri-prosthetic osteolysis in revision metal-on-metal total hip replacements. Hip International 25 (4), pp.355-360. (10.5301/hipint.5000241)
2014
- Vazquez, M. et al. 2014. A new method to investigate how mechanical loading of osteocytes controls osteoblasts. Frontiers in Endocrinology 5 208. (10.3389/fendo.2014.00208)
- Bonnet, C. S. et al. 2014. AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Annals of the Rheumatic Diseases 74 , pp.242-251. (10.1136/annrheumdis-2013-203670)
- Gilbert, S. J. et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5 174. (10.3389/fendo.2014.00174)
- Sanders, R. et al. 2014. Considerations for accurate gene expression measurement by reverse transcription quantitative PCR when analysing clinical samples. Analytical and Bioanalytical Chemistry 406 (26), pp.6471-6483. (10.1007/s00216-014-7857-x)
- Bonnet, C. et al. 2014. NBQX, a glutamate receptor antagonist, alleviates inflammation, pathology and gait abnormalities in a rat model of inflammatory arthritis. International Journal of Experimental Pathology 95 (3), pp.A5-A6. (10.1111/iep.12078)
- Gilbert, S. J. et al. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95 (3), pp.A11-A12. (10.1111/iep.12078)
- Scully, N. E. E. et al., 2014. Development of a novel 3D mineralising culture system to investigate the differentiation of osteoblasts to osteocytes. International Journal of Experimental Pathology 95 (3), pp.A29-A29. (10.1111/iep.12078)
- Vazquez, M. et al. 2014. Development of a novel in vitro 3D osteoblast-osteocyte co-culture model to investigate mechanically-induced signalling. International Journal of Experimental Pathology 95 (3), pp.A34-A35. (10.1111/iep.12078)
- Holt, C. A. et al. 2014. Correlating biomechanics and biological signals in subjects undergoing high tibial osteotomy. Presented at: Othopaedic Research Society New Orleans, LA, USA 15-18th March 2014.
2013
- Sanders, R. et al. 2013. Evaluation of digital PCR for absolute RNA quantification. PLoS ONE 8 (9) e75296. (10.1371/journal.pone.0075296)
2012
- Bonnet, C. et al. 2012. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. Osteoporosis International 23 , pp.S527-S527.
- Brakspear, K. S. and Mason, D. J. 2012. Glutamate signaling in bone. Frontiers in Endocrinology 3 97. (10.3389/fendo.2012.00097)
- Gilbert, S. J. et al. 2012. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials 23 , pp.41-57.
- Whatling, G. M. et al. 2012. Biomechanical and biological changes following high tibial osteotomy. Presented at: 18th Congress of the European Society of Biomechanics. Lisbon, Portugal 1-4 July 2012.
2011
- Parsons, P. et al., 2011. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. Journal of Biological Chemistry 286 (40), pp.34986-34997. (10.1074/jbc.M111.238188)
- Vazquez, M. et al. 2011. Bone in vitro 3D osteoblast-osteocyte co-culture model. International Journal of Experimental Pathology 92 (6), pp.A18-A18. (10.1111/j.1365-2613.2011.00780.x)
- Whatling, G. M. et al. 2011. High tibial osteotomy: linking biomechanical and biological changes. Presented at: British Orthopaedic Research Society Cambridge 27-29 June 2011.
2010
- Gilbert, S. J. et al. 2010. Knockout of P58(IPK), a known inhibitor of PKR, in mice results in a degenerative phenotype in the knee joint. International Journal of Experimental Pathology 91 (2), pp.A34-A34. (10.1111/j.1365-2613.2009.00690.x)
- Mason, D. J. et al. 2010. Glutamatergic signalling in the osteoarthritic knee. International Journal of Experimental Pathology 91 (2), pp.A34-A35. (10.1111/j.1365-2613.2009.00690.x)
- Mason, D. J. et al. 2010. Glutamatergic signals in human arthritis: A link between mechanical, nociceptive and pathological processes. Bone 46 , pp.S76. (10.1016/j.bone.2010.01.185)
- Mason, D. J. et al. 2010. Can joint realignment surgery reveal mechanically regulated signals that influence pain and pathology in humans?. Presented at: Annual Meeting of the European Research Society (EORS) Davos, Switzerland 30 June - 2 July 2010.
2009
- Brakspear, K. S. , Parsons, P. and Mason, D. J. 2009. Glutamate transporter inhibitors influence osteoblast gene expression and activity. International Journal of Experimental Pathology 90 (2), pp.A107-A108. (10.1111/j.1365-2613.2008.00644.x)
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncostatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90 (2), pp.A112-A112. (10.1111/j.1365-2613.2008.00644.x)
- Brakspear, K. S. , Parsons, P. and Mason, D. J. 2009. Glutamate transporter inhibitors influence osteoblast gene expression and activity [Abstract]. International Journal of Experimental Pathology 90 (2), pp.A107-A108. (10.1111/j.1365-2613.2009.00644.x)
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncastatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90 (2), pp.A112-A112.
- Mason, D. J. et al. 2009. Interactions between osteocytes and osteoblasts in a novel 3D co-culture system [Abstract]. International Journal of Experimental Pathology 90 (2), pp.A104. (10.1111/j.1365-2613.2008.00644.x)
2008
- Gilbert, S. J. et al. 2008. Sphingomyelinase decreases type II collagen expression in bovine articular chondrocytes via the ERK signalling pathway. Arthritis and Rheumatism 58 (1), pp.209-220. (10.1002/art.23172)
- Mason, D. et al. 2008. A 3D culture system to investigate osteocyte control of osteoblasts. Bone 42 (Suppl), pp.S26-S27. (10.1016/j.bone.2007.12.033)
2006
- Gilbert, S. J. et al. 2006. Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis research & therapy 8 (4) R89. (10.1186/ar1961)
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2006. Protein kinase R: A novel mediator of articular cartilage degradation in arthritis. Current Rheumatology Reviews 2 (1), pp.9-21. (10.2174/157339706775697026)
2004
- Mason, D. J. 2004. Glutamate signalling and its potential application to tissue engineering of bone. European Cells and Materials 7 , pp.12-26.
- Mason, D. J. 2004. The role of glutamate transporters in bone cell signalling. Journal of Musculoskeletal Neuronal Interactions 4 (2), pp.128-131.
2003
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2003. Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?. Arthritis Research & Therapy 6 (1), pp.R46-R55. (10.1186/ar1024)
- Blain, E. J. , Mason, D. J. and Duance, V. C. 2003. The effect of cyclical compressive loading on gene expression in articular cartilage. Biorheology 40 (1-3), pp.111-117.
- Mason, D. J. and Huggett, J. F. 2003. Elucidation of mechanically-regulated signalling pathways in bone and their application to bone tissue engineering. European Cells and Materials 5 (Supp 2), pp.26-27.
2002
- Blain, E. J. , Mason, D. J. and Duance, V. C. 2002. The effect of thymosin β4 on articular cartilage chondrocyte matrix metalloproteinase expression. Biochemical Society Transactions 30 (6), pp.879-882. (10.1042/BST0300879)
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocyte. Biochemical Society Transactions 30 , pp.886-889. (10.1042/bst0300886)
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocytes. Biochemical Society Transactions 30 (6), pp.886-889. (10.1042/BST0300886)
- Huggett, J. F. et al., 2002. The glutamate transporter GLAST-1 (EAAT-1) is expressed in the plasma membrane of osteocytes and is responsive to extracellular glutamate concentration.. Biochemical Society Transactions 30 (6), pp.890-893. (10.1042/BST0300890)
- Mason, D. 2002. Glutamate transporters in bone. Journal of Musculoskeletal and Neuronal Interactions 2 (5), pp.406-414.
2001
- Blain, E. J. et al. 2001. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Archives of biochemistry and biophysics 396 (1), pp.49-55. (10.1006/abbi.2001.2575)
- Skerry, T. et al., 2001. Absence of evidence is not evidence of absence; The shortcomings of the GLAST knockout mouse [Letter]. Journal of Bone and Mineral Research 16 (9), pp.1729-1730. (10.1359/jbmr.2001.16.9.1729)
2000
- Huggett, J. , Mason, D. J. and Vaughan-Thomas, A. 2000. The open reading frame of the Na+-dependent glutamate transporter GLAST-1 is expressed in bone and a splice variant of this molecule is expressed in bone and brain. FEBS Letters 485 (1), pp.13-18. (10.1016/S0014-5793(00)02175-X)
1997
- Mason, D. et al. 1997. Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents?. Bone 20 (3), pp.199-205.
1996
- Mason, D. J. , Hillam, R. and Skerry, T. 1996. Constitutive in vivo mRNA expression by osteocytes of β-actin, osteocalcin, connexin-43, IGF-I, c-fos and c-jun, but not TNF- nor tartrate-resistant acid phosphatase. Journal of Bone and Mineral Research 11 (3), pp.350-357. (10.1002/jbmr.5650110308)
1995
- Mason, D. J. , RK, B. and P, G. 1995. An unusual mitochondrial DNA polymorphism in the Chorthippus biguttulus species group (Orthoptera:Acrididae). Molecular Ecology 4 (1), pp.121-126. (10.1111/j.1365-294X.1995.tb00199.x)
Cynadleddau
- Hamilton, R. et al. 2023. Measuring osteoarthritis knee nociception using physiological and movement response and a defined thermal stimulus: A proof-of-concept study.. Presented at: The International Combined Orthopaedic Research Societies (ICORS), World Congress of Orthopaedic Research Edinburgh, UK 7-9 September 2022. Orthopaedic Proceedings. Vol. 105-B,., pp.20-20. (10.1302/1358-992X.2023.8.020)
- Hamilton, R. et al. 2021. Measuring nociception in knee osteoarthritis using physiological and movement responses: a proof-of-concept study. Presented at: British Orthopaedic Research Society Cardiff, UK 13-14 September 2021.
- Simonovic, J. , Holt, C. and Mason, D. 2019. Semantic insight and behaviour of the computational bone cell population models. Presented at: 25th Congress of the European Society of Biomechanics (ESB 2019) Vienna, Austria 7-10 July 2019. , pp.-.
- Holt, C. A. et al. 2014. Correlating biomechanics and biological signals in subjects undergoing high tibial osteotomy. Presented at: Othopaedic Research Society New Orleans, LA, USA 15-18th March 2014.
- Whatling, G. M. et al. 2012. Biomechanical and biological changes following high tibial osteotomy. Presented at: 18th Congress of the European Society of Biomechanics. Lisbon, Portugal 1-4 July 2012.
- Whatling, G. M. et al. 2011. High tibial osteotomy: linking biomechanical and biological changes. Presented at: British Orthopaedic Research Society Cambridge 27-29 June 2011.
- Mason, D. J. et al. 2010. Can joint realignment surgery reveal mechanically regulated signals that influence pain and pathology in humans?. Presented at: Annual Meeting of the European Research Society (EORS) Davos, Switzerland 30 June - 2 July 2010.
Erthyglau
- Rix, L. et al., 2026. A thematic narrative review of osteoarthritis risk factors across the female life course. International Journal of Molecular Sciences 27 (18) 8083. (10.3390/ijms27188083)
- Jones, R. , Gilbert, S. and Mason, D. 2026. A predictive model for the investigation of osteoarthritic pain [Abstract]. Osteoarthritis and Cartilage 34 (S), pp.S61. (10.1016/j.joca.2026.01.058)
- Jones, R. et al. 2026. Sex based differences in IPSC derived nociceptor responses to osteoarthritic synovial fluid [Abstract]. Osteoarthritis and Cartilage 34 (S), pp.S370-S371. (10.1016/j.joca.2026.01.534)
- Jones, R. et al. 2026. A comparison of IPSC derived nociceptors in modelling osteoarthritic pain [Abstract]. Osteoarthritis and Cartilage 34 (Supp), pp.S369-S370. (10.1016/j.joca.2026.01.532)
- Jones, R. et al. 2024. Osteocytes contribute to sex-specific differences in osteoarthritic pain. Frontiers in Endocrinology 15 1480274. (10.3389/fendo.2024.1480274)
- Kalsoum, R. et al., 2024. A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury.. Bone & Joint Research 13 (9), pp.513-524. (10.1302/2046-3758.139.BJR-2024-0109)
- Gilbert, S. J. et al. 2024. Investigating mechanical and inflammatory pathological mechanisms in osteoarthritis using MSC-derived osteocyte-like cells in 3D. Frontiers in Endocrinology 15 1359052. (10.3389/fendo.2024.1359052)
- Whittaker, J. L. et al., 2024. Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop. Osteoarthritis and Cartilage Open 6 (2) 100449. (10.1016/j.ocarto.2024.100449)
- Hamilton, R. et al. 2024. Utilising electrodermal activity sensor signals to quantify nociceptive response during movement activities. BMC Research Notes 17 36. (10.1186/s13104-024-06689-9)
- Gilbert, S. J. , Blain, E. J. and Mason, D. J. 2022. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms. Biochemistry and Biophysics Reports 32 101323. (10.1016/j.bbrep.2022.101323)
- Paskins, Z. et al., 2022. Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method. The Lancet Rheumatology 4 (9), pp.635-645. (10.1016/S2665-9913(22)00136-9)
- Mason, D. , Englund, M. and Watt, F. E. 2021. Prevention of posttraumatic osteoarthritis at the time of injury: Where are we now, and where are we going?. Journal of Orthopaedic Research 39 (6), pp.1152-1163. (10.1002/jor.24982)
- Bonnet, C. S. et al. 2020. AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis. JCI Insight 5 (13) e134055. (10.1172/jci.insight.134055)
- Khatib, N. et al. 2019. Dynamic medial knee overloading influences inflammation and bone remodeling in the degenerative knee [Abstract]. Osteoarthritis and Cartilage 27 (S1), pp.S44. 29. (10.1016/j.joca.2019.02.063)
- Watt, F. E. et al., 2019. Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury. Osteoarthritis and Cartilage 27 (1), pp.23-33. (10.1016/j.joca.2018.08.001)
- Gilbert, S. J. et al. 2018. Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis. Journal of Orthopaedic Research 36 (8), pp.2118-2127. (10.1002/jor.23872)
- Jähn, K. et al., 2018. Phenotype and viability of MLO-Y4 cells Is maintained by TGFβ3 in a serum-dependent manner within a 3D-co-culture with MG-63 cells. International Journal of Molecular Sciences 19 (7) 1932. (10.3390/ijms19071932)
- Sanders, R. et al., 2018. Improving the standardization of mRNA measurement by RT-qPCR. Biomolecular Detection and Quantification 15 , pp.13-17. (10.1016/j.bdq.2018.03.001)
- Khatib, N. et al. 2018. How does an AMPA/KA receptor antagonist affect the metabolic profile of a bone co-culture loading model? an NMR spectroscopy approach [Abstract]. International Journal of Experimental Pathology 98 (1), pp.A21. (10.1111/iep.12218)
- Holt, C. A. et al. 2016. Biological changes in tibial subchondral bone following high tibial osteotomy. Osteoarthritis and Cartilage 24 (S1), pp.S511-S511. (10.1016/j.joca.2016.01.935)
- Felson, D. T. et al., 2016. Recommendations for the conduct of efficacy trials of treatment devices for osteoarthritis: a report from a working group of the Arthritis Research UK Osteoarthritis and Crystal Diseases Clinical Studies Group. Rheumatology 55 (2), pp.320-326. (10.1093/rheumatology/kev328)
- Eastwood, S. E. et al., 2015. Osteoclastogenesis-related cytokines and peri-prosthetic osteolysis in revision metal-on-metal total hip replacements. Hip International 25 (4), pp.355-360. (10.5301/hipint.5000241)
- Vazquez, M. et al. 2014. A new method to investigate how mechanical loading of osteocytes controls osteoblasts. Frontiers in Endocrinology 5 208. (10.3389/fendo.2014.00208)
- Bonnet, C. S. et al. 2014. AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Annals of the Rheumatic Diseases 74 , pp.242-251. (10.1136/annrheumdis-2013-203670)
- Gilbert, S. J. et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5 174. (10.3389/fendo.2014.00174)
- Sanders, R. et al. 2014. Considerations for accurate gene expression measurement by reverse transcription quantitative PCR when analysing clinical samples. Analytical and Bioanalytical Chemistry 406 (26), pp.6471-6483. (10.1007/s00216-014-7857-x)
- Bonnet, C. et al. 2014. NBQX, a glutamate receptor antagonist, alleviates inflammation, pathology and gait abnormalities in a rat model of inflammatory arthritis. International Journal of Experimental Pathology 95 (3), pp.A5-A6. (10.1111/iep.12078)
- Gilbert, S. J. et al. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95 (3), pp.A11-A12. (10.1111/iep.12078)
- Scully, N. E. E. et al., 2014. Development of a novel 3D mineralising culture system to investigate the differentiation of osteoblasts to osteocytes. International Journal of Experimental Pathology 95 (3), pp.A29-A29. (10.1111/iep.12078)
- Vazquez, M. et al. 2014. Development of a novel in vitro 3D osteoblast-osteocyte co-culture model to investigate mechanically-induced signalling. International Journal of Experimental Pathology 95 (3), pp.A34-A35. (10.1111/iep.12078)
- Sanders, R. et al. 2013. Evaluation of digital PCR for absolute RNA quantification. PLoS ONE 8 (9) e75296. (10.1371/journal.pone.0075296)
- Bonnet, C. et al. 2012. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. Osteoporosis International 23 , pp.S527-S527.
- Brakspear, K. S. and Mason, D. J. 2012. Glutamate signaling in bone. Frontiers in Endocrinology 3 97. (10.3389/fendo.2012.00097)
- Gilbert, S. J. et al. 2012. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials 23 , pp.41-57.
- Parsons, P. et al., 2011. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. Journal of Biological Chemistry 286 (40), pp.34986-34997. (10.1074/jbc.M111.238188)
- Vazquez, M. et al. 2011. Bone in vitro 3D osteoblast-osteocyte co-culture model. International Journal of Experimental Pathology 92 (6), pp.A18-A18. (10.1111/j.1365-2613.2011.00780.x)
- Gilbert, S. J. et al. 2010. Knockout of P58(IPK), a known inhibitor of PKR, in mice results in a degenerative phenotype in the knee joint. International Journal of Experimental Pathology 91 (2), pp.A34-A34. (10.1111/j.1365-2613.2009.00690.x)
- Mason, D. J. et al. 2010. Glutamatergic signalling in the osteoarthritic knee. International Journal of Experimental Pathology 91 (2), pp.A34-A35. (10.1111/j.1365-2613.2009.00690.x)
- Mason, D. J. et al. 2010. Glutamatergic signals in human arthritis: A link between mechanical, nociceptive and pathological processes. Bone 46 , pp.S76. (10.1016/j.bone.2010.01.185)
- Brakspear, K. S. , Parsons, P. and Mason, D. J. 2009. Glutamate transporter inhibitors influence osteoblast gene expression and activity. International Journal of Experimental Pathology 90 (2), pp.A107-A108. (10.1111/j.1365-2613.2008.00644.x)
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncostatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90 (2), pp.A112-A112. (10.1111/j.1365-2613.2008.00644.x)
- Brakspear, K. S. , Parsons, P. and Mason, D. J. 2009. Glutamate transporter inhibitors influence osteoblast gene expression and activity [Abstract]. International Journal of Experimental Pathology 90 (2), pp.A107-A108. (10.1111/j.1365-2613.2009.00644.x)
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncastatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90 (2), pp.A112-A112.
- Mason, D. J. et al. 2009. Interactions between osteocytes and osteoblasts in a novel 3D co-culture system [Abstract]. International Journal of Experimental Pathology 90 (2), pp.A104. (10.1111/j.1365-2613.2008.00644.x)
- Gilbert, S. J. et al. 2008. Sphingomyelinase decreases type II collagen expression in bovine articular chondrocytes via the ERK signalling pathway. Arthritis and Rheumatism 58 (1), pp.209-220. (10.1002/art.23172)
- Mason, D. et al. 2008. A 3D culture system to investigate osteocyte control of osteoblasts. Bone 42 (Suppl), pp.S26-S27. (10.1016/j.bone.2007.12.033)
- Gilbert, S. J. et al. 2006. Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis research & therapy 8 (4) R89. (10.1186/ar1961)
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2006. Protein kinase R: A novel mediator of articular cartilage degradation in arthritis. Current Rheumatology Reviews 2 (1), pp.9-21. (10.2174/157339706775697026)
- Mason, D. J. 2004. Glutamate signalling and its potential application to tissue engineering of bone. European Cells and Materials 7 , pp.12-26.
- Mason, D. J. 2004. The role of glutamate transporters in bone cell signalling. Journal of Musculoskeletal Neuronal Interactions 4 (2), pp.128-131.
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2003. Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?. Arthritis Research & Therapy 6 (1), pp.R46-R55. (10.1186/ar1024)
- Blain, E. J. , Mason, D. J. and Duance, V. C. 2003. The effect of cyclical compressive loading on gene expression in articular cartilage. Biorheology 40 (1-3), pp.111-117.
- Mason, D. J. and Huggett, J. F. 2003. Elucidation of mechanically-regulated signalling pathways in bone and their application to bone tissue engineering. European Cells and Materials 5 (Supp 2), pp.26-27.
- Blain, E. J. , Mason, D. J. and Duance, V. C. 2002. The effect of thymosin β4 on articular cartilage chondrocyte matrix metalloproteinase expression. Biochemical Society Transactions 30 (6), pp.879-882. (10.1042/BST0300879)
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocyte. Biochemical Society Transactions 30 , pp.886-889. (10.1042/bst0300886)
- Gilbert, S. J. , Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocytes. Biochemical Society Transactions 30 (6), pp.886-889. (10.1042/BST0300886)
- Huggett, J. F. et al., 2002. The glutamate transporter GLAST-1 (EAAT-1) is expressed in the plasma membrane of osteocytes and is responsive to extracellular glutamate concentration.. Biochemical Society Transactions 30 (6), pp.890-893. (10.1042/BST0300890)
- Mason, D. 2002. Glutamate transporters in bone. Journal of Musculoskeletal and Neuronal Interactions 2 (5), pp.406-414.
- Blain, E. J. et al. 2001. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Archives of biochemistry and biophysics 396 (1), pp.49-55. (10.1006/abbi.2001.2575)
- Skerry, T. et al., 2001. Absence of evidence is not evidence of absence; The shortcomings of the GLAST knockout mouse [Letter]. Journal of Bone and Mineral Research 16 (9), pp.1729-1730. (10.1359/jbmr.2001.16.9.1729)
- Huggett, J. , Mason, D. J. and Vaughan-Thomas, A. 2000. The open reading frame of the Na+-dependent glutamate transporter GLAST-1 is expressed in bone and a splice variant of this molecule is expressed in bone and brain. FEBS Letters 485 (1), pp.13-18. (10.1016/S0014-5793(00)02175-X)
- Mason, D. et al. 1997. Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents?. Bone 20 (3), pp.199-205.
- Mason, D. J. , Hillam, R. and Skerry, T. 1996. Constitutive in vivo mRNA expression by osteocytes of β-actin, osteocalcin, connexin-43, IGF-I, c-fos and c-jun, but not TNF- nor tartrate-resistant acid phosphatase. Journal of Bone and Mineral Research 11 (3), pp.350-357. (10.1002/jbmr.5650110308)
- Mason, D. J. , RK, B. and P, G. 1995. An unusual mitochondrial DNA polymorphism in the Chorthippus biguttulus species group (Orthoptera:Acrididae). Molecular Ecology 4 (1), pp.121-126. (10.1111/j.1365-294X.1995.tb00199.x)
Ymchwil
I am a molecular and cell biologist in the field of musculoskeletal diseases. My research has revealed that glutamate release is regulated in arthritis, that glutamate receptors function in musculoskeletal tissues and that their inhibition protect against osteoarthritis in animal models. This is leading towards new therapies for osteoarthritis with given patents. We created cell, animal and human models to how mechanical loading influences osteoarthritis degeneration and pain. Our 3D bone models are being developed as drug screening tools, to reveal functional genomics underlying genom wide associations with osteoarthritis and to investigate bone-nerve interactions and pain. We are investigating sex specific mechanisms underlying osteoarthritis to explore why females are more vulnerable to osteoarthritis, and feel more pain, especially after menopause. My decision to bridge the translational gap between basic science discoveries and clinical medicine has extended my research to international workshops and papers on trial design for post-traumatic osteoarthritis.
Grantiau ymchwil cyfredol
- Diffinio Blaenoriaethau Ymchwil Drosiadol ar gyfer Osteoarthritis yn y Menopos: Amlddisgyblaethol
Astudiaeth Consensws Delphi (2026-27) £19,963 - SMART - Astudiaeth o Ddarlleniadau Moleciwlaidd a Chlinigol ar gyfer Osteoarthritis Trawmatig Pwmp NIHR - Canolfan Ymchwil Drosiadol Cyhyrysgerbydol y DU (2026-27) £2 9,978
- Canolfan Ymchwil Biomecaneg a Biopheirianneg yn erbyn Arthritis (2016-28) £2.27M
- Model nerf synhwyraidd esgyrn dynol i ymchwilio i boen sy'n deillio o esgyrn. NC3Rs (2023-26) £633,628
- Osteoarthritis nad yw'n radiograffig: astudiaeth metabolig, biocemegol a mynegiant RNA mewn cŵn â chlefyd/rhwyg ligament croesog cranial. (2024-26) BVOA £9948
Prosiectau diweddar
- Nodi mesurau gwrthrychol o boen rhyw-benodol mewn pobl y gellir eu defnyddio'n ddiagnostig i dargedu triniaeth. Orthopaedics Research UK (2024-25) £47,000
- Ymchwilio i dderbynyddion glutamad mewn osteoarthritis: Diwydiant (Ionawr-Hydref 2023) £172,000
- A allai triniaeth wrthlidiol wrth ailadeiladu ACL wella canlyniadau biolegol, swyddogaethol a chlinigol? Ysgoloriaethau Sgiliau Gwybodaeth, yr Economi 2 Prosiect Dwyrain Cymru (2020-23) £80,385
- Cyfieithu gwrthwynebwyr derbynyddion glutamad i osteoarthritis milfeddygol. Llywodraeth Cymru Arloesi i Bawb a Knoell Animal Health Ltd (2022-23) £10,000 PI Ymchwiliad peilot i fynegiant derbynyddion glwtamad mewn osteoarthritis. Orphelion (2021-22) £27,452
- Ymchwilio i dderbynyddion glwtamad mewn osteoarthritis: astudiaeth beilot a ariennir gan y diwydiant (Ebrill-Medi 2022) £71,271 PI Ffactorau biolegol, clinigol a biomecanyddol sy'n effeithio ar Lawfeddygaeth Osteotomi Tibial Uchel. Alison Kinghorn, prosiect MD (2018-2020) Yn erbyn Arthritis a Chanolfan Orthopedig Caerdydd a'r Fro £40,000
- Meintioli biofarcwyr llidiol ac OA cynnar mewn clefyd ligament croes cranial cŵn. Ymddiriedolaeth Elusennol Petplan (2021-2022) £9860CoI Mesurau nociceptive osteoarthritis. EPSRC (Ebrill - Awst 2022) £42805.
- Modelu mechanotransduction o'r gilfach esgyrn sy'n gyrru canser metastatig y prostad. Ymchwil Canser Cymru (2019-21) £147,301
- Rôl maint, siâp a strwythur esgyrn a chymalau, wrth esbonio clefydau cyhyrysgerbydol cyffredin. Gwobr Cydweithredu Ymddiriedolaeth Wellcome (2018-23) £1,565,599
- Ailbwrpasu AMP397 i atal osteoarthritis ôl-drawmatig. Yn erbyn Arthritis (2019-22) £49,064
- Gwrthwynebwyr derbynnydd glwtamad fel dull newydd o drin clefyd ligament croes mewn cŵn – astudiaeth arsylwadol. Cymdeithas Orthopedig Milfeddygol Prydain (2017-19) £4,582
Cydweithrediadau Cyfredol
Diwydiant Ysbytai Arloesi, Novartis, Orphelion Yr Athro Tobias (Bryste), Mr Wilson (Ymddiriedolaeth GIG Caerdydd a'r Fro), Dr Fiona Watt (Imperial), Yr Athro Karina Wright (Keele), Mr Stephen McDonnell (Caergrawnt), Yr Athro Mandy Peffers (Lerpwl), Dr Charlotte Hulme (Keele). Caerdydd Yr Athro Cathy Holt (Peirianneg), Dr David Williams (Peirianneg), Dr Emma Blain (Biowyddorau).
Aelodau cyfredol y grŵp ymchwil
- Dr Ryan Jones
- Mr Joel Alves
Addysgu
I am an enthusiastic and effective lecturer contributing to a range of teaching activities (tutorials, lectures, workshops, practical, projects) across various levels and Degree Schemes (BSc: Biomolecular, Biomedical, Medical, Dental; MSc). I adapt my methods according to student feedback, peer assessment and student achievement. As Level 1 Co-ordinator for Biochemistry Degree Schemes, Molecular Biology Degree Scheme Co-ordinator and Final Year Tutor for all Biomolecular Schemes I have made major contributions to management, teaching, course design and administration.
I currently Lead the final year Contemporary Topics in Disease Module, where cutting edge research in the School of Biosciences demonstrates how research can reveal pathological mechanisms and identify and test new treatments across a wide range of diseases.
Bywgraffiad
Mae Deborah Mason yn Athro yn yr Ysgol Biowyddorau ac yn Gyd-gyfarwyddwr Canolfan Ragoriaeth Biomecaneg a Biobeirianneg Arthritis UK ym Mhrifysgol Caerdydd. Mae ei rhaglen ymchwil yn defnyddio ystod o fodelau celloedd, explant, anifeiliaid a dynol i benderfynu sut mae biomecaneg ar y cyd yn dylanwadu ar signalau biolegol. Ar ôl ei BSc mewn Sŵoleg a Geneteg a PhD mewn Geneteg Esblygiadol, roedd ei hymchwil ôl-ddoethurol yn ymwneud â signalau glutamatergig mewn ffurfio esgyrn a achosir gan fecanyddiaeth. Ers hynny, mae hi wedi arwain >40 o brosiectau ymchwil sy'n cwmpasu biogwyddorau, peirianneg ac orthopaedeg. Mae ei hymchwil wedi nodi targedau cyffuriau a biomarcwyr newydd ar gyfer osteoarthritis, ac wedi datblygu modelau in vitro newydd ar gyfer sgrinio cyffuriau a dewis biofarcwyr. Mae hyn wedi arwain at patentau a chydweithredu â chwmnïau fferyllol. Ei huchelgais gyffredinol yw gwella dealltwriaeth o'r mecanweithiau biolegol sy'n cysylltu llwyth mecanyddol, poen, llid a dinistrio cymalau mewn arthritis, a manteisio ar y wybodaeth hon er budd cleifion. Bu'n gyn-Lywydd Cymdeithas Ymchwil Orthopedig Prydain ac mae wedi gwasanaethu ar Bwyllgorau ar gyfer y Cymdeithasau Ymchwil Orthopedig Cyfunol Rhyngwladol, Cymdeithas Ymchwil Orthopedig, Cymdeithas Ymchwil Orthopedig Prydain a Chymdeithas Ymchwil Esgyrn. Mae hi wedi trefnu a chyhoeddi allbynnau o weithdai rhyngwladol ar sut i gynnal treialon clinigol ar gyfer osteoarthritis ôl-drawmatig. Mae hi'n cyfrannu'n helaeth at weithgareddau addysgu ac ymgysylltu â'r cyhoedd.
.
Anrhydeddau a dyfarniadau
- Medal y Llywydd, Cymdeithas Ymchwil Orthopedig Prydain (2024)
- Cymrawd Cymdeithas Ymchwil Orthopedig Ryngwladol (2022)
Aelodaethau proffesiynol
- Cymdeithasau Ymchwil Orthopedig Cyfun Rhyngwladol (2020-26)
- Cymdeithas Ymchwil Orthopedig Prydain (2018-26)
- Cymdeithas Ymchwil Orthopedig (2017-25)
- Cymdeithas Ymchwil Orthopedig Ewrop (2017-25)
- Cymdeithas Ymchwil Esgyrn (2008-22)
- Cymdeithas Ymchwil Esgyrn America (2009-2016)
Ymrwymiadau siarad cyhoeddus
Sgyrsiau gwahoddedig rhyngwladol
- 'Y cysyniad o Cyn-Osteoarthritis neu A ellir diffinio Osteoarthritis cyn iddo ddod yn berthnasol yn glinigol? Cyfarfod Blynyddol Cymdeithas Ymchwil Orthopaedig, San Francisco, UDA (Chwefror, 2027)
- 'Datblygu model nerf synhwyraidd esgyrn: gwersi a ddysgwyd o ymchwil i boen mewn osteoarthritis' Cynhadledd y Gymdeithas Ymchwil Orthopedig Gyfunol Ryngwladol yn Adelaide, Awstralia (Hydref, 2025)
- 'Cysyniad Biolegol Cyn-OA'. Cynhadledd y Gymdeithas Ymchwil Orthopedig Cyfunol Ryngwladol yn Adelaide, Awstralia (Hydref, 2025)
- 'Defnyddio modelau celloedd a dynol i adnabod gyrwyr mecanyddol osteoarthritis'. Cyfarfod Blynyddol Cymdeithas Ymchwil Orthopedig Ewrop, Davos, y Swistir (Mehefin, 2025)
Sgyrsiau gwahoddedig cenedlaethol
- 'Ail-bwrpasu triniaethau epilepsi i atal osteoarthritis.' Cyngres Flynyddol Cymdeithas Orthopedig Prydain, 16eg – 18fed Lerpwl, (Medi, 2025).
- 'O esgyrn i'r ymennydd (ac yn ôl eto?).' Darlith Medal y Llywydd Cymdeithas Ymchwil Orthopedig Prydain, Sheffield (Medi, 2024).
Pwyllgorau ac adolygu
PWYLLGORAU
- Coleg Arbenigwyr Arthritis y DU (2026-)
- Tasglu ansawdd, amrywiaeth a chynhwysiant E, Cymdeithasau Ymchwil Orthopedig Cyfun Rhyngwladol (2026-)
- Cadeirydd yr Ymddiriedolwyr, ac Ymddiriedolwr, Cymdeithas Ymchwil Orthopedig Prydain (2020-26)
- Pwyllgor Cymdeithasau Ymchwil Orthopedig Cyfun Rhyngwladol (2021-22)
- Llywydd, Cymdeithas Ymchwil Orthopedig Prydain (2020-22)
- Pwyllgor Ymchwil Cymdeithas Orthopedig Prydain (2020-22)
- Cadeirydd Pwnc Esgyrn, Cymdeithas Ymchwil Orthopedig (2019-20)
- Pwyllgor Gweithredol, Cymdeithas Ymchwil Orthopedig Prydain (2018-22)
- Pwyllgor y Rhaglen, Cymdeithas Ymchwil Esgyrn a Chymdeithas Ymchwil Orthopedig Prydain (2019)
- Pwyllgor y Rhaglen, Cymdeithas Ymchwil Orthopedig (UDA) (2017-19)
- Pwyllgor Gwyddonol, Cymdeithas Ymchwil Orthopedig Ewrop (2017-18)
- Pwyllgor Dyfarniad Cymrodoriaeth Arthritis Research UK (2017-18)
- Is-bwyllgor Clefydau Ymchwil Arthritis y DU (2017)
- Pwyllgor Gwaith, Cymdeithas Ymchwil Esgyrn (2010-13)
- Cadeirydd Pwyllgor Rhaglen, Cymdeithas Ymchwil Orthopedig Prydain (2009-10)
ROLAU CYNGHORI
- Grŵp Cynghori Ymchwil Cyhyrysgerbydol, Arweinydd Thema Cyfieithu, Versus Arthritis (2019-2026)
- Bwrdd Cynghori Gwyddonol, Canolfan Ymchwil Biofeddygol NIHR Leeds ar gyfer Treialon Cyhyrysgerbydol (2019)
- Adolygydd REF ar gyfer Peirianneg Biofeddygol, Prifysgol Strathclyde (2019)
Meysydd goruchwyliaeth
I am interested in supervising students in the areas of:
- developing new preventative treatments for osteoarthritis
- early diagnosis of osteoarthritis
- cell models for drug screening
Ymgysylltu
ArrayNews articles
Contact Details
Themâu ymchwil
Arbenigeddau
- Osteoarthritis
- signalau glutamad
- osteocytiau
- Mechanofioleg
- Mecanweithiau clefydau
