Professor Deborah Mason

2024

• Jones, R., Gilbert, S. J., Christofides, S. R. and Mason, D. J. 2024. Osteocytes contribute to sex-specific differences in osteoarthritic pain. Frontiers in Endocrinology 15, article number: 1480274. (10.3389/fendo.2024.1480274)
• Kalsoum, R. et al. 2024. A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury.. Bone & Joint Research 13(9), pp. 513-524. (10.1302/2046-3758.139.BJR-2024-0109)
• Gilbert, S. J., Jones, R., Egan, B. J., Bonnet, C. S., Evans, S. L. and Mason, D. J. 2024. Investigating mechanical and inflammatory pathological mechanisms in osteoarthritis using MSC-derived osteocyte-like cells in 3D. Frontiers in Endocrinology 15, article number: 1359052. (10.3389/fendo.2024.1359052)
• Whittaker, J. L. et al. 2024. Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop. Osteoarthritis and Cartilage Open 6(2), article number: 100449. (10.1016/j.ocarto.2024.100449)
• Hamilton, R., Garcia, A. A., Bowd, J., Hamilton, D., Mason, D., Elliott, M. and Holt, C. 2024. Utilising electrodermal activity sensor signals to quantify nociceptive response during movement activities. BMC Research Notes 17, article number: 36. (10.1186/s13104-024-06689-9)

2023

• Hamilton, R. et al. 2023. Measuring osteoarthritis knee nociception using physiological and movement response and a defined thermal stimulus: A proof-of-concept study.. Presented at: The International Combined Orthopaedic Research Societies (ICORS), World Congress of Orthopaedic Research, Edinburgh, UK, 7-9 September 2022Orthopaedic Proceedings, Vol. 105-B,. pp. 20-20., (10.1302/1358-992X.2023.8.020)

2022

• Gilbert, S. J., Blain, E. J. and Mason, D. J. 2022. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms. Biochemistry and Biophysics Reports 32, article number: 101323. (10.1016/j.bbrep.2022.101323)
• Paskins, Z. et al. 2022. Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method. The Lancet Rheumatology 4(9), pp. 635-645. (10.1016/S2665-9913(22)00136-9)

2021

• Hamilton, R., Holt, C., Jones, R., Shillabeer, D., Sparkes, V. and Mason, D. 2021. Measuring nociception in knee osteoarthritis using physiological and movement responses: a proof-of-concept study. Presented at: British Orthopaedic Research Society, Cardiff, UK, 13-14 September 2021.
• Mason, D., Englund, M. and Watt, F. E. 2021. Prevention of posttraumatic osteoarthritis at the time of injury: Where are we now, and where are we going?. Journal of Orthopaedic Research 39(6), pp. 1152-1163. (10.1002/jor.24982)

2020

• Bonnet, C. S., Gilbert, S. J., Blain, E. J., Williams, A. S. and Mason, D. J. 2020. AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis. JCI Insight 5(13), article number: e134055. (10.1172/jci.insight.134055)

2019

• Khatib, N., Biggs, P., Wilson, C., Williams, R., Mason, D. and Holt, C. 2019. Dynamic medial knee overloading influences inflammation and bone remodeling in the degenerative knee [Abstract]. Osteoarthritis and Cartilage 27(S1), pp. S44., article number: 29. (10.1016/j.joca.2019.02.063)
• Simonovic, J., Holt, C. and Mason, D. 2019. Semantic insight and behaviour of the computational bone cell population models. Presented at: 25th Congress of the European Society of Biomechanics (ESB 2019), Vienna, Austria, 7-10 July 2019. pp. -.
• Watt, F. E. et al. 2019. Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury. Osteoarthritis and Cartilage 27(1), pp. 23-33. (10.1016/j.joca.2018.08.001)

2018

• Gilbert, S. J., Bonnet, C. S., Stadnik, P., Duance, V. C., Mason, D. J. and Blain, E. J. 2018. Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis. Journal of Orthopaedic Research 36(8), pp. 2118-2127. (10.1002/jor.23872)
• Jähn, K., Mason, D., Ralphs, J., Evans, B., Archer, C., Richards, R. G. and Stoddart, M. 2018. Phenotype and viability of MLO-Y4 cells Is maintained by TGFβ3 in a serum-dependent manner within a 3D-co-culture with MG-63 cells. International Journal of Molecular Sciences 19(7), article number: 1932. (10.3390/ijms19071932)
• Sanders, R., Bustin, S., Huggett, J. and Mason, D. 2018. Improving the standardization of mRNA measurement by RT-qPCR. Biomolecular Detection and Quantification 15, pp. 13-17. (10.1016/j.bdq.2018.03.001)
• Khatib, N., Papageorgiou, A., Vazquez, M., Flintoft, F., Holt, C. and Mason, D. 2018. How does an AMPA/KA receptor antagonist affect the metabolic profile of a bone co-culture loading model? an NMR spectroscopy approach [Abstract]. International Journal of Experimental Pathology 98(1), pp. A21. (10.1111/iep.12218)

2016

• Holt, C. A. et al. 2016. Biological changes in tibial subchondral bone following high tibial osteotomy. Osteoarthritis and Cartilage 24(S1), pp. S511-S511. (10.1016/j.joca.2016.01.935)
• Felson, D. T. et al. 2016. Recommendations for the conduct of efficacy trials of treatment devices for osteoarthritis: a report from a working group of the Arthritis Research UK Osteoarthritis and Crystal Diseases Clinical Studies Group. Rheumatology 55(2), pp. 320-326. (10.1093/rheumatology/kev328)

2015

• Eastwood, S. E., John, A., Jones, S. A., Hodgson, H., Mason, D. J., Waddington, R. and Wei, X. 2015. Osteoclastogenesis-related cytokines and peri-prosthetic osteolysis in revision metal-on-metal total hip replacements. Hip International 25(4), pp. 355-360. (10.5301/hipint.5000241)

2014

• Vazquez, M., Evans, B. A. J., Riccardi, D., Evans, S. L., Ralphs, J. R., Dillingham, C. M. and Mason, D. J. 2014. A new method to investigate how mechanical loading of osteocytes controls osteoblasts. Frontiers in Endocrinology 5, article number: 208. (10.3389/fendo.2014.00208)
• Bonnet, C. S., Williams, A. S., Gilbert, S. J., Harvey, A. K., Evans, B. A. and Mason, D. J. 2014. AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Annals of the Rheumatic Diseases 74, pp. 242-251. (10.1136/annrheumdis-2013-203670)
• Gilbert, S. J. et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5, article number: 174. (10.3389/fendo.2014.00174)
• Sanders, R., Mason, D. J., Foy, C. A. and Huggett, J. F. 2014. Considerations for accurate gene expression measurement by reverse transcription quantitative PCR when analysing clinical samples. Analytical and Bioanalytical Chemistry 406(26), pp. 6471-6483. (10.1007/s00216-014-7857-x)
• Bonnet, C., Williams, A. S., Gilbert, S. J., Harvey, A., Evans, B. A. J. and Mason, D. J. 2014. NBQX, a glutamate receptor antagonist, alleviates inflammation, pathology and gait abnormalities in a rat model of inflammatory arthritis. International Journal of Experimental Pathology 95(3), pp. A5-A6. (10.1111/iep.12078)
• Vazquez, M., Evans, B., Evans, S., Ralphs, J., Riccardi, D. and Mason, D. 2014. Development of a novel in vitro 3D osteoblast-osteocyte co-culture model to investigate mechanically-induced signalling. International Journal of Experimental Pathology 95(3), pp. A34-A35. (10.1111/iep.12078)
• Scully, N. E. E., Evans, S. L., Mason, D. J. and Evans, B. A. J. 2014. Development of a novel 3D mineralising culture system to investigate the differentiation of osteoblasts to osteocytes. International Journal of Experimental Pathology 95(3), pp. A29-A29. (10.1111/iep.12078)
• Gilbert, S. J., Meakin, L. B., Mason, D. J., Duance, V. C. and Blain, E. J. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95(3), pp. A11-A12. (10.1111/iep.12078)
• Holt, C. A., Whatling, G. M., Bonnet, C., Brakspear, K., Wilson, C., Williams, R. and Mason, D. J. 2014. Correlating biomechanics and biological signals in subjects undergoing high tibial osteotomy. Presented at: Othopaedic Research Society, New Orleans, LA, USA, 15-18th March 2014.

2013

• Sanders, R., Mason, D. J., Foy, C. A. and Huggett, J. F. 2013. Evaluation of digital PCR for absolute RNA quantification. PLoS ONE 8(9), article number: e75296. (10.1371/journal.pone.0075296)

2012

• Brakspear, K. S. and Mason, D. J. 2012. Glutamate signaling in bone. Frontiers in Endocrinology 3, article number: 97. (10.3389/fendo.2012.00097)
• Bonnet, C., Williams, A. S., Harvey, A., Gilbert, S. J., Moideen, A. N., Nowell, M. A. and Mason, D. J. 2012. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. Osteoporosis International 23, pp. S527-S527.
• Gilbert, S. J., Blain, E. J., Al-Sabah, A., Zhang, Y., Duance, V. C. and Mason, D. J. 2012. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials 23, pp. 41-57.
• Whatling, G. M., Mason, D., Brakspear, K., Roberts, H., Watling, D., Metcalfe, A. and Holt, C. A. 2012. Biomechanical and biological changes following high tibial osteotomy. Presented at: 18th Congress of the European Society of Biomechanics., Lisbon, Portugal, 1-4 July 2012.

2011

• Vazquez, M., Evans, B. A. J., Ralphs, J. R., Riccardi, D. and Mason, D. J. 2011. Bone in vitro 3D osteoblast-osteocyte co-culture model. International Journal of Experimental Pathology 92(6), pp. A18-A18. (10.1111/j.1365-2613.2011.00780.x)
• Parsons, P. et al. 2011. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
• Parsons, P. et al. 2011. Identification of a type IX collagen interaction with fibronectin: a molecular bridge in articular cartilage?. The Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
• Whatling, G. M. et al. 2011. High tibial osteotomy: linking biomechanical and biological changes. Presented at: British Orthopaedic Research Society, Cambridge, 27-29 June 2011.

2010

• Gilbert, S. J., Patel, M., Toumi, H., Duance, V. C. and Mason, D. J. 2010. Knockout of P58(IPK), a known inhibitor of PKR, in mice results in a degenerative phenotype in the knee joint. International Journal of Experimental Pathology 91(2), pp. A34-A34. (10.1111/j.1365-2613.2009.00690.x)
• Mason, D. J., Brakspear, K. S., Wilson, C., Williams, R. and Kotwal, R. S. 2010. Glutamatergic signalling in the osteoarthritic knee. International Journal of Experimental Pathology 91(2), pp. A34-A35. (10.1111/j.1365-2613.2009.00690.x)
• Mason, D. J., Brakspear, K., Wilson, C., Williams, R. and Kotwal, R. 2010. Glutamatergic signals in human arthritis: A link between mechanical, nociceptive and pathological processes. Bone 46, pp. S76. (10.1016/j.bone.2010.01.185)
• Mason, D. J. et al. 2010. Can joint realignment surgery reveal mechanically regulated signals that influence pain and pathology in humans?. Presented at: Annual Meeting of the European Research Society (EORS), Davos, Switzerland, 30 June - 2 July 2010.

2009

• Brakspear, K. S., Parsons, P. and Mason, D. J. 2009. Glutamate transporter inhibitors influence osteoblast gene expression and activity. International Journal of Experimental Pathology 90(2), pp. A107-A108. (10.1111/j.1365-2613.2008.00644.x)
• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncostatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112. (10.1111/j.1365-2613.2008.00644.x)
• Mason, D. J., Dillingham, C. M., Williams, S. E., Evans, B. A. J., Brakspear, K. S. and Ralphs, J. 2009. Interactions between osteocytes and osteoblasts in a novel 3D co-culture system [Abstract]. International Journal of Experimental Pathology 90(2), pp. A104. (10.1111/j.1365-2613.2008.00644.x)
• Brakspear, K. S., Parsons, P. and Mason, D. J. 2009. Glutamate transporter inhibitors influence osteoblast gene expression and activity [Abstract]. International Journal of Experimental Pathology 90(2), pp. A107-A108. (10.1111/j.1365-2613.2009.00644.x)
• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncastatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112.

2008

• Gilbert, S. J., Blain, E. J., Duance, V. C. and Mason, D. J. 2008. Sphingomyelinase decreases type II collagen expression in bovine articular chondrocytes via the ERK signalling pathway. Arthritis and Rheumatism 58(1), pp. 209-220. (10.1002/art.23172)
• Mason, D., Dillingham, C. M., Evans, B. A., Brakspear, K. S. and Ralphs, J. R. 2008. A 3D culture system to investigate osteocyte control of osteoblasts. Bone 42(Suppl), pp. S26-S27. (10.1016/j.bone.2007.12.033)

2006

• Gilbert, S. J., Blain, E. J., Jones, P., Duance, V. C. and Mason, D. J. 2006. Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis research & therapy 8(4), article number: R89. (10.1186/ar1961)
• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2006. Protein kinase R: A novel mediator of articular cartilage degradation in arthritis. Current Rheumatology Reviews 2(1), pp. 9-21. (10.2174/157339706775697026)

2004

• Mason, D. J. 2004. Glutamate signalling and its potential application to tissue engineering of bone. European Cells and Materials 7, pp. 12-26.
• Mason, D. J. 2004. The role of glutamate transporters in bone cell signalling. Journal of Musculoskeletal Neuronal Interactions 4(2), pp. 128-131.

2003

• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2003. Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?. Arthritis Research & Therapy 6(1), pp. R46-R55. (10.1186/ar1024)
• Blain, E. J., Mason, D. J. and Duance, V. C. 2003. The effect of cyclical compressive loading on gene expression in articular cartilage. Biorheology 40(1-3), pp. 111-117.
• Mason, D. J. and Huggett, J. F. 2003. Elucidation of mechanically-regulated signalling pathways in bone and their application to bone tissue engineering. European Cells and Materials 5(Supp 2), pp. 26-27.

2002

• Huggett, J. F., Mustafa, A., O'Neal, L. and Mason, D. J. 2002. The glutamate transporter GLAST-1 (EAAT-1) is expressed in the plasma membrane of osteocytes and is responsive to extracellular glutamate concentration.. Biochemical Society Transactions 30(6), pp. 890-893. (10.1042/BST0300890)
• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocytes. Biochemical Society Transactions 30(6), pp. 886-889. (10.1042/BST0300886)
• Blain, E. J., Mason, D. J. and Duance, V. C. 2002. The effect of thymosin β4 on articular cartilage chondrocyte matrix metalloproteinase expression. Biochemical Society Transactions 30(6), pp. 879-882. (10.1042/BST0300879)
• Mason, D. 2002. Glutamate transporters in bone. Journal of Musculoskeletal and Neuronal Interactions 2(5), pp. 406-414.
• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocyte. Biochemical Society Transactions 30, pp. 886-889. (10.1042/bst0300886)

2001

• Blain, E. J., Gilbert, S. J., Wardale, R. J., Capper, S. J., Mason, D. J. and Duance, V. C. 2001. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Archives of biochemistry and biophysics 396(1), pp. 49-55. (10.1006/abbi.2001.2575)
• Skerry, T., Genever, P., Taylor, A., Dobson, K., Mason, D. J. and Suva, L. 2001. Absence of evidence is not evidence of absence: The shortcomings of the GLAST knockout mouse [2] [Abstract]. Journal of Bone and Mineral Research 16(9), pp. 1729-1730. (10.1359/jbmr.2001.16.9.1729)
• Skerry, T., Genever, P., Taylor, A., Dobson, K., Mason, D. J. and Suva, L. 2001. Absence of evidence is not evidence of absence; The shortcomings of the GLAST knockout mouse [Letter]. Journal of Bone and Mineral Research 16(9), pp. 1729-1730. (10.1359/jbmr.2001.16.9.1729)

2000

• Huggett, J., Mason, D. J. and Vaughan-Thomas, A. 2000. The open reading frame of the Na+-dependent glutamate transporter GLAST-1 is expressed in bone and a splice variant of this molecule is expressed in bone and brain. FEBS Letters 485(1), pp. 13-18. (10.1016/S0014-5793(00)02175-X)

1997

• Mason, D., Suva, L. J., Genever, P. G., Patton, A. J., Steuckle, S., Hillam, R. A. and Skerry, T. M. 1997. Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents?. Bone 20(3), pp. 199-205.

1996

• Mason, D. J., Hillam, R. and Skerry, T. 1996. Constitutive in vivo mRNA expression by osteocytes of β-actin, osteocalcin, connexin-43, IGF-I, c-fos and c-jun, but not TNF- nor tartrate-resistant acid phosphatase. Journal of Bone and Mineral Research 11(3), pp. 350-357. (10.1002/jbmr.5650110308)

1995

• Mason, D. J., RK, B. and P, G. 1995. An unusual mitochondrial DNA polymorphism in the Chorthippus biguttulus species group (Orthoptera:Acrididae). Molecular Ecology 4(1), pp. 121-126. (10.1111/j.1365-294X.1995.tb00199.x)