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Dr Arthur Morris
Cymrawd Ymchwil Uwch HCRW
Ysgol y Biowyddorau
Trosolwyg
Cymrawd Ymchwil Iechyd a Gofal Cymru (Llywodraeth Cymru) 2024-2027 - Rhyddhau Genomeg Modern ar gyfer Gwyliadwriaeth Iechyd Cyhoeddus Manwl o Cryptosporidium
Mae fy ymchwil yn canolbwyntio ar ddatblygu a chymhwyso dulliau cyfrifiadurol i ddadansoddi genomau pathogen. Drwy gydweithio'n agos ag Iechyd Cyhoeddus Cymru, fy nod yw integreiddio'r offer a'r methodolegau hyn yn ddi-dor i ymarfer clinigol.
Mae fy niddordebau ymchwil yn cynnwys:
- Genomeg Cryptosporidium: Cyflogi genomeg poblogaeth i ddyfnhau ein dealltwriaeth o'r parasit un gell hwn a dyfeisio strategaethau i darfu ar ei drosglwyddiad.
- Methodolegau Cyfrifiadurol Newydd: Creu meddalwedd newydd ar gyfer dadansoddi genomau pathogen effeithlon, a gynlluniwyd i'w weithredu gan asiantaethau iechyd cyhoeddus.
- Gwyliadwriaeth Dŵr Gwastraff: Dadansoddi DNA o ddŵr gwastraff i fonitro mynychder pathogen o fewn y boblogaeth leol.
- Epidemioleg SARS-CoV-2 : Ymchwilio i epidemioleg SARS-CoV-2 yng Nghymru drwy gydol y pandemig.
Cyhoeddiad
2023
- Morris, A. V., Price, A. and Connor, T. 2023. Afanc: a metagenomics tool for variant level disambiguation of NGS datasets. [Online]. bioRXiv. (10.1101/2023.10.05.560444) Available at: https://doi.org/10.1101/2023.10.05.560444
- Cotton, S. et al. 2023. Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes. Journal of Hospital Infection 135, pp. 28-36. (10.1016/j.jhin.2023.02.010)
2022
- Willett, B. J. et al. 2022. SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology 7, pp. 1161-1179. (10.1038/s41564-022-01143-7)
- Eales, O. et al. 2022. SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2. BMC Infectious Diseases 22(1), article number: 647. (10.1186/s12879-022-07628-4)
- Nickbakhsh, S. et al. 2022. Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning. Scientific Reports 12(1), article number: 11735. (10.1038/s41598-022-15661-1)
- Kläser, K. et al. 2022. COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study. Scientific Reports 12(1), article number: 10904. (10.1038/s41598-022-14016-0)
2021
- Vöhringer, H. S. et al. 2021. Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature 600(7889), pp. 506-511. (10.1038/s41586-021-04069-y)
2020
- Morris, A., Pachebat, J., Tyson, G., Robinson, G., Chalmers, R. and Swain, M. 2020. Generating reliable genome assemblies of intestinal protozoans from clinical samples for the purpose of biomarker discovery. Presented at: Biomedical Engineering Systems and Technologies BIOSTEC 2019, Prague, Czech Republic, 22-24 February 2019 Presented at Roque, A. et al. eds.Communications in Computer and Information Science, Vol. 1211. Springer, Cham pp. 216-241., (10.1007/978-3-030-46970-2_11)
2019
- Morris, A., Robinson, G., Swain, M. T. and Chalmers, R. M. 2019. Direct sequencing of Cryptosporidium in stool samples for public health. Frontiers in Public Health 7 (10.3389/fpubh.2019.00360)
- Swain, M., Chalmers, R., Robinson, G., Pachebat, J. and Morris, A. 2019. Identifying and resolving genome misassembly issues important for biomarker discovery in the protozoan parasite, cryptosporidium. Presented at: 12th International Joint Conference on Biomedical Engineering Systems and Technologies, Prague, Czech Republic, 22–24 February 2019Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies, Vol. 3. pp. 90-100., (10.5220/0007397200900100)
2017
- Castro, P. D. J. and Morris, A. V. 2017. Burrowing mites in companion animals. UK-VET Companion animal 22(8), pp. 446-452. (10.12968/coan.2017.22.8.446)
2016
- Castro, P. D. J. and Morris, A. V. 2016. Feline lungworm: biology, epidemiology, diagnosis and treatment. The Veterinary Nurse 7(9), pp. 508-513. (10.12968/vetn.2016.7.9.508)
Articles
- Cotton, S. et al. 2023. Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes. Journal of Hospital Infection 135, pp. 28-36. (10.1016/j.jhin.2023.02.010)
- Willett, B. J. et al. 2022. SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology 7, pp. 1161-1179. (10.1038/s41564-022-01143-7)
- Eales, O. et al. 2022. SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2. BMC Infectious Diseases 22(1), article number: 647. (10.1186/s12879-022-07628-4)
- Nickbakhsh, S. et al. 2022. Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning. Scientific Reports 12(1), article number: 11735. (10.1038/s41598-022-15661-1)
- Kläser, K. et al. 2022. COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study. Scientific Reports 12(1), article number: 10904. (10.1038/s41598-022-14016-0)
- Vöhringer, H. S. et al. 2021. Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature 600(7889), pp. 506-511. (10.1038/s41586-021-04069-y)
- Morris, A., Robinson, G., Swain, M. T. and Chalmers, R. M. 2019. Direct sequencing of Cryptosporidium in stool samples for public health. Frontiers in Public Health 7 (10.3389/fpubh.2019.00360)
- Castro, P. D. J. and Morris, A. V. 2017. Burrowing mites in companion animals. UK-VET Companion animal 22(8), pp. 446-452. (10.12968/coan.2017.22.8.446)
- Castro, P. D. J. and Morris, A. V. 2016. Feline lungworm: biology, epidemiology, diagnosis and treatment. The Veterinary Nurse 7(9), pp. 508-513. (10.12968/vetn.2016.7.9.508)
Conferences
- Morris, A., Pachebat, J., Tyson, G., Robinson, G., Chalmers, R. and Swain, M. 2020. Generating reliable genome assemblies of intestinal protozoans from clinical samples for the purpose of biomarker discovery. Presented at: Biomedical Engineering Systems and Technologies BIOSTEC 2019, Prague, Czech Republic, 22-24 February 2019 Presented at Roque, A. et al. eds.Communications in Computer and Information Science, Vol. 1211. Springer, Cham pp. 216-241., (10.1007/978-3-030-46970-2_11)
- Swain, M., Chalmers, R., Robinson, G., Pachebat, J. and Morris, A. 2019. Identifying and resolving genome misassembly issues important for biomarker discovery in the protozoan parasite, cryptosporidium. Presented at: 12th International Joint Conference on Biomedical Engineering Systems and Technologies, Prague, Czech Republic, 22–24 February 2019Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies, Vol. 3. pp. 90-100., (10.5220/0007397200900100)
Websites
- Morris, A. V., Price, A. and Connor, T. 2023. Afanc: a metagenomics tool for variant level disambiguation of NGS datasets. [Online]. bioRXiv. (10.1101/2023.10.05.560444) Available at: https://doi.org/10.1101/2023.10.05.560444
Contact Details
Themâu ymchwil
Arbenigeddau
- Biowybodeg a bioleg gyfrifiadurol
- Genomeg pathogen
- Biostatistics