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Dr Arthur Morris
Timau a rolau for Arthur Morris
Cymrawd Ymchwil Uwch HCRW
Ysgol y Biowyddorau
Trosolwg
Rwy'n Gymrawd Ymchwil Uwch Ymchwil Iechyd a Gofal Cymru sy'n arbenigo mewn genomeg pathogenau, geneteg poblogaeth a bioleg gyfrifiadurol. Mae fy ymchwil yn cyfuno datblygu dulliau cyfrifiadurol newydd gyda dadansoddiad genomig ar raddfa fawr i ddeall sut mae poblogaethau pathogenau yn dod i'r amlwg, yn esblygu ac yn lledaenu, ac i drosi ymchwil genomig yn offer ymarferol ar gyfer iechyd y cyhoedd a biogwyliadwriaeth.
Un o brif ffocws fy ymchwil bresennol yw genomeg poblogaeth a gwyliadwriaeth genomig Cryptosporidium, achos pwysig o glefyd gastroberfeddol mewn pobl ac anifeiliaid. Trwy fy Nghrodoriaeth Ymchwil Uwch Ymchwil Iechyd a Gofal Cymru, rwy'n gweithio'n agos gydag Iechyd Cyhoeddus Cymru, gan gynnwys yr Uned Gyfeirio Cryptosporidium a'r Uned Genomeg Pathogen, i sefydlu dulliau genomig ar gyfer gwyliadwriaeth Cryptosporidium arferol yng Nghymru a'r DU ehangach. Mae'r rhaglen hon yn adeiladu ar fy ngwaith blaenorol ym maes gwyliadwriaeth genomig pathogen cenedlaethol ac yn archwilio strwythur poblogaeth pathogen, heintiau cymysg, ailgyfuno a throsglwyddo wrth ddatblygu'r seilwaith labordy a chyfrifiadurol sydd ei angen i symud dulliau genomig i ymarfer gweithredol.
Ochr yn ochr â hyn, rwy'n datblygu dulliau cyfrifiadurol ar gyfer dadansoddi genomig pathogen a fforensig microbaidd. Mae fy ymchwil wedi cynhyrchu dulliau ar gyfer adnabod tacsonomig, aseiniad llinach, dadansoddi genomig poblogaeth, canfod heintiau cymysg a chanfod anghysondebau genomig. Mae fy ngwaith blaenorol wedi cyfrannu at ddatblygu piblinellau gwyliadwriaeth genomig a ddefnyddir bellach yn iechyd cyhoeddus y DU, ac rwy'n parhau i weithio gyda chydweithwyr ar draws sawl sector cyhoeddus i ddatblygu dulliau a all weithredu ar y raddfa a'r dibynadwyedd sydd eu hangen ar gyfer gwyliadwriaeth genomig yn y byd go iawn.
Mae fy niddordebau ymchwil yn cynnwys:
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Genomeg ac esblygiad poblogaeth pathogen: Defnyddio setiau data genomig mawr i ymchwilio i strwythur poblogaeth pathogen, trosglwyddo, ailgyfuno, cyfnewid genetig a newid esblygiadol.
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Genomeg a gwyliadwriaeth Cryptosporidium: Datblygu dulliau genomig i ddeall trosglwyddiad ac esblygiad Cryptosporidium a sefydlu gwyliadwriaeth genomig arferol ar gyfer y pathogen hwn sy'n bwysig yn fyd-eang.
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Genomeg gyfrifiadurol: Datblygu meddalwedd effeithlon a graddadwy ar gyfer dadansoddi genom pathogen, gan gynnwys dulliau ar gyfer aseinio llinach, dadansoddi heintiau cymysg, genomeg poblogaeth a chanfod anghysondebau genomig.
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Epidemioleg genomig a biogwyliadwriaeth: Cyfieithu dulliau genomig i systemau gweithredol ar gyfer canfod, nodweddu a gwyliadwriaeth pathogenau mewn cydweithrediad â phartneriaid sector cyhoeddus.
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Fforensig microbaidd a chanfod anghysondebau genomig: Datblygu dulliau cyfrifiadurol i nodi nodweddion genomig anarferol sy'n berthnasol i wyliadwriaeth fiolegol.
Cyhoeddiad
2025
- Morris, A. V. et al. 2025. Investigating within-host population diversity of Cryptosporidium parvum using BlooMine. BMC Genomics 26 (1) 1067. (10.1186/s12864-025-12206-4)
- Morris, A. V. et al. 2025. Parapipe: a pipeline for parasite next-generation sequencing data analysis applied to Cryptosporidium. Access Microbiology 7 (8)(10.1099/acmi.0.000993.v3)
2023
- Morris, A. V. , Price, A. and Connor, T. 2023. Afanc: a metagenomics tool for variant level disambiguation of NGS datasets. bioRxiv (10.1101/2023.10.05.560444)
- Cotton, S. et al., 2023. Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes. Journal of Hospital Infection 135 , pp.28-36. (10.1016/j.jhin.2023.02.010)
2022
- Willett, B. J. et al., 2022. SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology 7 , pp.1161-1179. (10.1038/s41564-022-01143-7)
- Eales, O. et al., 2022. SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2. BMC Infectious Diseases 22 (1) 647. (10.1186/s12879-022-07628-4)
- Nickbakhsh, S. et al., 2022. Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning. Scientific Reports 12 (1) 11735. (10.1038/s41598-022-15661-1)
- Kläser, K. et al., 2022. COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study. Scientific Reports 12 (1) 10904. (10.1038/s41598-022-14016-0)
2021
- Vöhringer, H. S. et al., 2021. Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature 600 (7889), pp.506-511. (10.1038/s41586-021-04069-y)
2020
- Morris, A. et al. 2020. Generating reliable genome assemblies of intestinal protozoans from clinical samples for the purpose of biomarker discovery. Presented at: Biomedical Engineering Systems and Technologies BIOSTEC 2019 Prague, Czech Republic 22-24 February 2019. Published in: Roque, A. et al., Communications in Computer and Information Science. Vol. 1211.Springer, Cham. , pp.216-241. (10.1007/978-3-030-46970-2_11)
2019
- Morris, A. et al. 2019. Direct sequencing of Cryptosporidium in stool samples for public health. Frontiers in Public Health 7 (10.3389/fpubh.2019.00360)
- Swain, M. et al., 2019. Identifying and resolving genome misassembly issues important for biomarker discovery in the protozoan parasite, cryptosporidium. Presented at: 12th International Joint Conference on Biomedical Engineering Systems and Technologies Prague, Czech Republic 22–24 February 2019. Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies. Vol. 3., pp.90-100. (10.5220/0007397200900100)
2017
- Castro, P. D. J. and Morris, A. V. 2017. Burrowing mites in companion animals. UK-VET Companion animal 22 (8), pp.446-452. (10.12968/coan.2017.22.8.446)
2016
- Castro, P. D. J. and Morris, A. V. 2016. Feline lungworm: biology, epidemiology, diagnosis and treatment. The Veterinary Nurse 7 (9), pp.508-513. (10.12968/vetn.2016.7.9.508)
Articles
- Morris, A. V. et al. 2025. Investigating within-host population diversity of Cryptosporidium parvum using BlooMine. BMC Genomics 26 (1) 1067. (10.1186/s12864-025-12206-4)
- Morris, A. V. et al. 2025. Parapipe: a pipeline for parasite next-generation sequencing data analysis applied to Cryptosporidium. Access Microbiology 7 (8)(10.1099/acmi.0.000993.v3)
- Morris, A. V. , Price, A. and Connor, T. 2023. Afanc: a metagenomics tool for variant level disambiguation of NGS datasets. bioRxiv (10.1101/2023.10.05.560444)
- Cotton, S. et al., 2023. Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes. Journal of Hospital Infection 135 , pp.28-36. (10.1016/j.jhin.2023.02.010)
- Willett, B. J. et al., 2022. SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology 7 , pp.1161-1179. (10.1038/s41564-022-01143-7)
- Eales, O. et al., 2022. SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2. BMC Infectious Diseases 22 (1) 647. (10.1186/s12879-022-07628-4)
- Nickbakhsh, S. et al., 2022. Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning. Scientific Reports 12 (1) 11735. (10.1038/s41598-022-15661-1)
- Kläser, K. et al., 2022. COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study. Scientific Reports 12 (1) 10904. (10.1038/s41598-022-14016-0)
- Vöhringer, H. S. et al., 2021. Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature 600 (7889), pp.506-511. (10.1038/s41586-021-04069-y)
- Morris, A. et al. 2019. Direct sequencing of Cryptosporidium in stool samples for public health. Frontiers in Public Health 7 (10.3389/fpubh.2019.00360)
- Castro, P. D. J. and Morris, A. V. 2017. Burrowing mites in companion animals. UK-VET Companion animal 22 (8), pp.446-452. (10.12968/coan.2017.22.8.446)
- Castro, P. D. J. and Morris, A. V. 2016. Feline lungworm: biology, epidemiology, diagnosis and treatment. The Veterinary Nurse 7 (9), pp.508-513. (10.12968/vetn.2016.7.9.508)
Conferences
- Morris, A. et al. 2020. Generating reliable genome assemblies of intestinal protozoans from clinical samples for the purpose of biomarker discovery. Presented at: Biomedical Engineering Systems and Technologies BIOSTEC 2019 Prague, Czech Republic 22-24 February 2019. Published in: Roque, A. et al., Communications in Computer and Information Science. Vol. 1211.Springer, Cham. , pp.216-241. (10.1007/978-3-030-46970-2_11)
- Swain, M. et al., 2019. Identifying and resolving genome misassembly issues important for biomarker discovery in the protozoan parasite, cryptosporidium. Presented at: 12th International Joint Conference on Biomedical Engineering Systems and Technologies Prague, Czech Republic 22–24 February 2019. Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies. Vol. 3., pp.90-100. (10.5220/0007397200900100)
Ymchwil
Ar hyn o bryd rwy'n brif ymchwilydd ar ddau brosiect ymchwil.
Rhyddhau genomeg fodern ar gyfer gwyliadwriaeth iechyd cyhoeddus manwl gywirdeb o Cryptosporidium - a ariennir gan ymchwil Iechyd a Gofal Cymru.
Rwy'n cydweithio ag Uned Gyfeirio Cryptosporidium y DU, rydym yn bwriadu sefydlu'r labordy a'r methodolegau cyfrifiadurol ar gyfer y gwasanaeth gwyliadwriaeth genomig Cryptosporidium cenedlaethol cyntaf.
Chasing GHOSTs: canfod anghysondebau genomig sy'n ymwybodol o'r cyd-destun gydag Afanc-detect - a ariennir gan y Labordy Gwyddoniaeth a Thechnoleg Amddiffyn fel rhan o Gyflymydd Amddiffyn a Diogelwch y DU.
Nod y prosiect hwn yw penderfynu a yw digwyddiad sy'n ymwneud â pherygl biolegol yn naturiol neu'n niweidiol o ran tarddiad. Ein nod yw defnyddio pŵer genomeg a thechnegau modelu ystadegol i ddatblygu methodolegau sy'n darparu mwy o wybodaeth nag adnabod organeb fiolegol.
Contact Details
Themâu ymchwil
Arbenigeddau
- Biowybodeg a bioleg gyfrifiadurol
- Genomeg pathogen
- Biostatistics