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Trosolwyg
Rwyf wedi cael fy hyfforddi fel cemegydd organig ond rwyf bob amser wedi cael fy ngyrru gan ddiddordeb dwfn mewn bioleg. Mae fy ymchwil yn canolbwyntio ar ysgogi pŵer cemeg synthetig i fynd i'r afael â heriau biofeddygol cymhleth. Mae ein grŵp yn harneisio polymerau allgellog matrics sy'n deillio o bolymerau megis asid hyaluronig a collagen a pholymerau synthetig i ddatblygu sgaffaldiau 3D mimetig ECM, dylunio nanoddeunyddiau swyddogaethol a defnyddio'r polymerau hyn i beiriannu peirianneg bôn-gelloedd.
Mae'r sgaffaldiau hydrogel wedi'u cynllunio i ddynwared y micro-amgylchedd meinwe naturiol, gan chwarae rhan hanfodol wrth fodiwleiddio gwahaniaethu bôn-gelloedd neu bolareiddio macrophage, sy'n hanfodol ar gyfer adfywio meinwe effeithiol. Ar hyn o bryd rydym yn datblygu sgaffaldiau hydrogel meinwe meinwe uwch ar gyfer amrywiaeth o gymwysiadau, gan gynnwys: (i) modelu microamgylcheddau tiwmor (megis modelau canser yr ymennydd a'r prostad), (ii) creu bioinks ar gyfer bioargraffu 3D, a (iii) darparu bôn-gelloedd neu ffactorau twf i gynorthwyo mewn adfywio meinwe (targedu meinweoedd fel cardiac, esgyrn, cornbilen, ac adfywio niwronau).
Yn ogystal â sgaffaldiau hydrogel, mae ein hymchwil yn defnyddio'r biopolymerau hyn i ddylunio nanoddeunyddiau arloesol, megis nanoronynnau aur, nanoronynnau ocsid haearn, a micelles polymerig, sy'n manteisio ar eu priodweddau immunomodulatory. Mae'r nanoronynnau hyn sy'n deillio o fiopolymer yn gwella amser cylchrediad y gwaed, yn darparu nodweddion llechwraidd, ac yn lleihau effeithiau oddi ar darged, ac yn targedu derbynyddion penodol fel CD44 ac EGFR sy'n cael eu gorfynegi ar sawl tiwmor solet gan eu gwneud yn hynod effeithiol ar gyfer cymwysiadau cyflenwi cyffuriau neu genynnau wedi'u targedu. Un o brif nodau fy ymchwil yw datblygu systemau cyflenwi cyffuriau ar gyfer targedu'r ymennydd i drin clefydau niwrolegol ac ar gyfer targedu canser y prostad. Mae'r Biobeirianneg a Nanofeddygaeth, yn seiliedig ar ymchwil amlddisgyblaethol arloesol ym meysydd bioddeunyddiau, peirianneg meinwe, cyflenwi cyffuriau, nanofeddygaeth, therapi sy'n seiliedig ar gelloedd, ac imiwnotherapi.
Cyhoeddiad
2025
- Roshanbinfar, K. et al. 2025. Enhancing biofabrication: Shrink-resistant collagen-hyaluronan composite hydrogel for tissue engineering and 3D bioprinting applications. Biomaterials 318, article number: 123174. (10.1016/j.biomaterials.2025.123174)
2024
- Evans, A. D., Pournoori, N., Saksala, E. and Oommen, O. P. 2024. Glycosaminoglycans' for brain health: Harnessing glycosaminoglycan based biomaterials for treating central nervous system diseases and in-vitro modeling. Biomaterials 309, article number: 122629. (10.1016/j.biomaterials.2024.122629)
- Guelfi, G. et al. 2024. Mimic miRNA and Anti-miRNA activated scaffolds as a therapeutic strategy to promote bone, cartilage, and skin regeneration. Macromol 4(2), pp. 165-189. (10.3390/macromol4020009)
2023
- Tavakoli, S., Evans, A., Oommen, O. P., Creemers, L., Nandi, J. B., Hilborn, J. and Varghese, O. P. 2023. Unveiling extracellular matrix assembly. Materials Today Bio 22, article number: 100768. (10.1016/j.mtbio.2023.100768)
- Rangasami, V. K. et al. 2023. Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function. Biomaterials Advances 147, article number: 213331. (10.1016/j.bioadv.2023.213331)
- Mörö, A. et al. 2023. Hyaluronic acid based next generation bioink for 3D bioprinting of human stem cell derived corneal stromal model with innervation. Biofabrication 15(1), article number: 15020. (10.1088/1758-5090/acab34)
- Tavakoli, S., Krishnan, N., Mokhtari, H., Oommen, O. P. and Varghese, O. P. 2023. Fine‐tuning dynamic cross–linking for enhanced 3D bioprinting of hyaluronic acid hydrogels. Advanced Functional Materials 34(4), article number: 2307040. (10.1002/adfm.202307040)
2022
- Samanta, S. et al. 2022. Heparin‐derived theranostic nanoprobes overcome the blood–brain barrier and target glioma in murine model. Advanced Therapeutics 5(6), article number: 2200001. (10.1002/adtp.202200001)
- Samanta, S. et al. 2022. Interpenetrating gallol functionalized tissue adhesive hyaluronic acid hydrogel polarizes macrophages to an immunosuppressive phenotype. Acta Biomaterialia 142, pp. 36-48. (10.1016/j.actbio.2022.01.048)
- Samanta, S., Ylä-Outinen, L., Rangasami, V. K., Narkilahti, S. and Oommen, O. P. 2022. Bidirectional cell-matrix interaction dictates neuronal network formation in a brain-mimetic 3D scaffold. Acta Biomaterialia 140, pp. 314-323. (10.1016/j.actbio.2021.12.010)
- Wang, S., Tavakoli, S., Parvathaneni, R. P., Nawale, G. N., Oommen, O. P., Hilborn, J. and Varghese, O. P. 2022. Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications. Biomaterials Science 10(22), pp. 6399-6412. (10.1039/d2bm01154a)
2021
- Edwards, K. et al. 2021. Hyaluronic acid-functionalized nanomicelles enhance SAHA efficacy in 3D endometrial cancer models. Cancers 13(16), article number: 4032. (10.3390/cancers13164032)
- Syed, S. et al. 2021. Streptococcus pneumoniae pneumolysin and neuraminidase A convert high density lipoproteins into pro-atherogenic particles. iScience 24(6), article number: 102535. (10.1016/j.isci.2021.102535)
- Kadekar, S. et al. 2021. Redox Responsive Pluronic Micelle Mediated Delivery of Functional siRNA: A Modular Nano-Assembly for Targeted Delivery. Biomaterials Science 9(11), pp. 3939-3944. (10.1039/d1bm00428j)
- Samanta, S., Rangasami, V. K., Murugan, N. A., Parihar, V. S., Varghese, O. P. and Oommen, O. P. 2021. An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels. Polymer Chemistry 12(20), pp. 2987-2991. (10.1039/d1py00013f)
- Rangasami, V. K. et al. 2021. Pluronic micelle-mediated tissue factor silencing enhances hemocompatibility, stemness, differentiation potential, and paracrine signaling of mesenchymal stem cells.. Biomacromolecules 22(8), pp. 1980-1989. (10.1021/acs.biomac.1c00070)
- Samal, J. R. K., Rangasami, V. K., Samanta, S., Varghese, O. P. and Oommen, O. P. 2021. Discrepancies on the role of oxygen gradient and culture condition on mesenchymal stem cell fate.. Advanced Healthcare Materials 10(6), article number: 2002058. (10.1002/adhm.202002058)
- Rangasami, V. K. et al. 2021. Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor macrophage polarization. Carbohydrate Polymers 254, article number: 117291. (10.1016/j.carbpol.2020.117291)
- Jowett, G. M. et al. 2021. ILC1 drive intestinal epithelial and matrix remodelling. Nature Materials 20, pp. 250-259. (10.1038/s41563-020-0783-8)
2020
- Jones, J. M. et al. 2020. Hyaluronan derived nanoparticle for simvastatin delivery: evaluation of simvastatin induced myotoxicity in tissue engineered skeletal muscle. Biomaterials Science 8(1), pp. 302-312. (10.1039/c9bm00986h)
2019
- Koivusalo, L. et al. 2019. Tissue adhesive hyaluronic acid hydrogels for sutureless stem cell delivery and regeneration of corneal epithelium and stroma. Biomaterials 225, article number: 119516. (10.1016/j.biomaterials.2019.119516)
- Bermejo-Velasco, D., Kadekar, S., da Costa, M. V. T., Oommen, O. P., Gamstedt, K., Hilborn, J. and Varghese, O. P. 2019. First aldol cross-linked hyaluronic acid hydrogel: Fast and hydrolytically stable hydrogel with tissue adhesive properties. ACS Applied Materials & Interfaces 11(41), pp. 38232-38239. (10.1021/acsami.9b10239)
- Roshanbinfar, K., Mohammadi, Z., Mesgar, A. S., Dehghan, M. M., Oommen, O. P., Hilborn, J. and Engel, F. B. 2019. Carbon nanotube doped pericardial matrix derived electroconductive biohybrid hydrogel for cardiac tissue engineering. Biomaterials Science 7(9), pp. 3906-3917. (10.1039/c9bm00434c)
- Kadekar, S., Nawale, G. N., Karlsson, K., Ålander, C., Oommen, O. P. and Varghese, O. P. 2019. Synthetic design of ssymmetric miRNA with an engineered 3′ overhang to improve strand selection. Molecular Therapy - Nucleic Acids 16, pp. 597-604. (10.1016/j.omtn.2019.04.012)
- Paidikondala, M. et al. 2019. An unexpected role of hyaluronic acid in trafficking siRNA across the cellular barrier: The first biomimetic, anionic, non-viral transfection method. Angewandte Chemie - International Edition 58(9), pp. 2815-2819. (10.1002/anie.201900099)
- Bermejo-Velasco, D., Azémar, A., Oommen, O. P., Hilborn, J. and Varghese, O. P. 2019. Modulating thiol p K a promotes disulfide formation at physiological pH: An elegant strategy to design disulfide cross-linked hyaluronic acid hydrogels. Biomacromolecules 20(3), pp. 1412-1420. (10.1021/acs.biomac.8b01830)
- Wang, S., Nawale, G. N., Oommen, O. P., Hilborn, J. and Varghese, O. P. 2019. Influence of ions to modulate hydrazone and oxime reaction kinetics to obtain dynamically cross-linked hyaluronic acid hydrogels. Polymer Chemistry 10(31), pp. 4322-4327. (10.1039/c9py00862d)
2018
- Bermejo-Velasco, D., Nawale, G. N., Oommen, O. P., Hilborn, J. and Varghese, O. P. 2018. Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH. Chemical Communications 54(88), pp. 12507-12510. (10.1039/c8cc05405c)
- Ferreira, S. A. et al. 2018. Bi-directional cell-pericellular matrix interactions direct stem cell fate. Nature Communications 9, article number: 4049. (10.1038/s41467-018-06183-4)
- Yan, H. J. et al. 2018. Synthetic design of growth factor sequestering extracellular matrix mimetic hydrogel for promoting in vivo bone formation. Biomaterials 161, pp. 190-202. (10.1016/j.biomaterials.2018.01.041)
- Wang, S. et al. 2018. Saline accelerates oxime reaction with aldehyde and keto substrates at physiological pH. Scientific Reports 8(1), article number: 2193. (10.1038/s41598-018-20735-0)
2017
- Guelfi, G. et al. 2017. Gold nanoparticles approach to detect chondroitin sulphate and hyaluronic acid urothelial coating. Scientific Reports 7(1), article number: 10355. (10.1038/s41598-017-09872-0)
- Roshanbinfar, K., Hilborn, J., Varghese, O. P. and Oommen, O. P. 2017. Injectable and thermoresponsive pericardial matrix derived conductive scaffold for cardiac tissue engineering. RSC Adv. 7, pp. 31980-31988. (10.1039/C7RA03780E)
2016
- Varghese, O. P., Liu, J., Sundaram, K., Hilborn, J. and Oommen, O. P. 2016. Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery.. Biomaterials Science 4(9), pp. 1310-1313. (10.1039/c6bm00335d)
2015
- Gurav, D., Varghese, O. P., Hamad, O. A., Nilsson, B., Hilborn, J. and Oommen, O. P. 2015. Chondroitin sulfate coated gold nanoparticles: a new strategy to resolve multidrug resistance and thromboinflammation. Chemical Communications 52(5), pp. 966-969. (10.1039/c5cc09215a)
Erthyglau
- Roshanbinfar, K. et al. 2025. Enhancing biofabrication: Shrink-resistant collagen-hyaluronan composite hydrogel for tissue engineering and 3D bioprinting applications. Biomaterials 318, article number: 123174. (10.1016/j.biomaterials.2025.123174)
- Evans, A. D., Pournoori, N., Saksala, E. and Oommen, O. P. 2024. Glycosaminoglycans' for brain health: Harnessing glycosaminoglycan based biomaterials for treating central nervous system diseases and in-vitro modeling. Biomaterials 309, article number: 122629. (10.1016/j.biomaterials.2024.122629)
- Guelfi, G. et al. 2024. Mimic miRNA and Anti-miRNA activated scaffolds as a therapeutic strategy to promote bone, cartilage, and skin regeneration. Macromol 4(2), pp. 165-189. (10.3390/macromol4020009)
- Tavakoli, S., Evans, A., Oommen, O. P., Creemers, L., Nandi, J. B., Hilborn, J. and Varghese, O. P. 2023. Unveiling extracellular matrix assembly. Materials Today Bio 22, article number: 100768. (10.1016/j.mtbio.2023.100768)
- Rangasami, V. K. et al. 2023. Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function. Biomaterials Advances 147, article number: 213331. (10.1016/j.bioadv.2023.213331)
- Mörö, A. et al. 2023. Hyaluronic acid based next generation bioink for 3D bioprinting of human stem cell derived corneal stromal model with innervation. Biofabrication 15(1), article number: 15020. (10.1088/1758-5090/acab34)
- Tavakoli, S., Krishnan, N., Mokhtari, H., Oommen, O. P. and Varghese, O. P. 2023. Fine‐tuning dynamic cross–linking for enhanced 3D bioprinting of hyaluronic acid hydrogels. Advanced Functional Materials 34(4), article number: 2307040. (10.1002/adfm.202307040)
- Samanta, S. et al. 2022. Heparin‐derived theranostic nanoprobes overcome the blood–brain barrier and target glioma in murine model. Advanced Therapeutics 5(6), article number: 2200001. (10.1002/adtp.202200001)
- Samanta, S. et al. 2022. Interpenetrating gallol functionalized tissue adhesive hyaluronic acid hydrogel polarizes macrophages to an immunosuppressive phenotype. Acta Biomaterialia 142, pp. 36-48. (10.1016/j.actbio.2022.01.048)
- Samanta, S., Ylä-Outinen, L., Rangasami, V. K., Narkilahti, S. and Oommen, O. P. 2022. Bidirectional cell-matrix interaction dictates neuronal network formation in a brain-mimetic 3D scaffold. Acta Biomaterialia 140, pp. 314-323. (10.1016/j.actbio.2021.12.010)
- Wang, S., Tavakoli, S., Parvathaneni, R. P., Nawale, G. N., Oommen, O. P., Hilborn, J. and Varghese, O. P. 2022. Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications. Biomaterials Science 10(22), pp. 6399-6412. (10.1039/d2bm01154a)
- Edwards, K. et al. 2021. Hyaluronic acid-functionalized nanomicelles enhance SAHA efficacy in 3D endometrial cancer models. Cancers 13(16), article number: 4032. (10.3390/cancers13164032)
- Syed, S. et al. 2021. Streptococcus pneumoniae pneumolysin and neuraminidase A convert high density lipoproteins into pro-atherogenic particles. iScience 24(6), article number: 102535. (10.1016/j.isci.2021.102535)
- Kadekar, S. et al. 2021. Redox Responsive Pluronic Micelle Mediated Delivery of Functional siRNA: A Modular Nano-Assembly for Targeted Delivery. Biomaterials Science 9(11), pp. 3939-3944. (10.1039/d1bm00428j)
- Samanta, S., Rangasami, V. K., Murugan, N. A., Parihar, V. S., Varghese, O. P. and Oommen, O. P. 2021. An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels. Polymer Chemistry 12(20), pp. 2987-2991. (10.1039/d1py00013f)
- Rangasami, V. K. et al. 2021. Pluronic micelle-mediated tissue factor silencing enhances hemocompatibility, stemness, differentiation potential, and paracrine signaling of mesenchymal stem cells.. Biomacromolecules 22(8), pp. 1980-1989. (10.1021/acs.biomac.1c00070)
- Samal, J. R. K., Rangasami, V. K., Samanta, S., Varghese, O. P. and Oommen, O. P. 2021. Discrepancies on the role of oxygen gradient and culture condition on mesenchymal stem cell fate.. Advanced Healthcare Materials 10(6), article number: 2002058. (10.1002/adhm.202002058)
- Rangasami, V. K. et al. 2021. Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor macrophage polarization. Carbohydrate Polymers 254, article number: 117291. (10.1016/j.carbpol.2020.117291)
- Jowett, G. M. et al. 2021. ILC1 drive intestinal epithelial and matrix remodelling. Nature Materials 20, pp. 250-259. (10.1038/s41563-020-0783-8)
- Jones, J. M. et al. 2020. Hyaluronan derived nanoparticle for simvastatin delivery: evaluation of simvastatin induced myotoxicity in tissue engineered skeletal muscle. Biomaterials Science 8(1), pp. 302-312. (10.1039/c9bm00986h)
- Koivusalo, L. et al. 2019. Tissue adhesive hyaluronic acid hydrogels for sutureless stem cell delivery and regeneration of corneal epithelium and stroma. Biomaterials 225, article number: 119516. (10.1016/j.biomaterials.2019.119516)
- Bermejo-Velasco, D., Kadekar, S., da Costa, M. V. T., Oommen, O. P., Gamstedt, K., Hilborn, J. and Varghese, O. P. 2019. First aldol cross-linked hyaluronic acid hydrogel: Fast and hydrolytically stable hydrogel with tissue adhesive properties. ACS Applied Materials & Interfaces 11(41), pp. 38232-38239. (10.1021/acsami.9b10239)
- Roshanbinfar, K., Mohammadi, Z., Mesgar, A. S., Dehghan, M. M., Oommen, O. P., Hilborn, J. and Engel, F. B. 2019. Carbon nanotube doped pericardial matrix derived electroconductive biohybrid hydrogel for cardiac tissue engineering. Biomaterials Science 7(9), pp. 3906-3917. (10.1039/c9bm00434c)
- Kadekar, S., Nawale, G. N., Karlsson, K., Ålander, C., Oommen, O. P. and Varghese, O. P. 2019. Synthetic design of ssymmetric miRNA with an engineered 3′ overhang to improve strand selection. Molecular Therapy - Nucleic Acids 16, pp. 597-604. (10.1016/j.omtn.2019.04.012)
- Paidikondala, M. et al. 2019. An unexpected role of hyaluronic acid in trafficking siRNA across the cellular barrier: The first biomimetic, anionic, non-viral transfection method. Angewandte Chemie - International Edition 58(9), pp. 2815-2819. (10.1002/anie.201900099)
- Bermejo-Velasco, D., Azémar, A., Oommen, O. P., Hilborn, J. and Varghese, O. P. 2019. Modulating thiol p K a promotes disulfide formation at physiological pH: An elegant strategy to design disulfide cross-linked hyaluronic acid hydrogels. Biomacromolecules 20(3), pp. 1412-1420. (10.1021/acs.biomac.8b01830)
- Wang, S., Nawale, G. N., Oommen, O. P., Hilborn, J. and Varghese, O. P. 2019. Influence of ions to modulate hydrazone and oxime reaction kinetics to obtain dynamically cross-linked hyaluronic acid hydrogels. Polymer Chemistry 10(31), pp. 4322-4327. (10.1039/c9py00862d)
- Bermejo-Velasco, D., Nawale, G. N., Oommen, O. P., Hilborn, J. and Varghese, O. P. 2018. Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH. Chemical Communications 54(88), pp. 12507-12510. (10.1039/c8cc05405c)
- Ferreira, S. A. et al. 2018. Bi-directional cell-pericellular matrix interactions direct stem cell fate. Nature Communications 9, article number: 4049. (10.1038/s41467-018-06183-4)
- Yan, H. J. et al. 2018. Synthetic design of growth factor sequestering extracellular matrix mimetic hydrogel for promoting in vivo bone formation. Biomaterials 161, pp. 190-202. (10.1016/j.biomaterials.2018.01.041)
- Wang, S. et al. 2018. Saline accelerates oxime reaction with aldehyde and keto substrates at physiological pH. Scientific Reports 8(1), article number: 2193. (10.1038/s41598-018-20735-0)
- Guelfi, G. et al. 2017. Gold nanoparticles approach to detect chondroitin sulphate and hyaluronic acid urothelial coating. Scientific Reports 7(1), article number: 10355. (10.1038/s41598-017-09872-0)
- Roshanbinfar, K., Hilborn, J., Varghese, O. P. and Oommen, O. P. 2017. Injectable and thermoresponsive pericardial matrix derived conductive scaffold for cardiac tissue engineering. RSC Adv. 7, pp. 31980-31988. (10.1039/C7RA03780E)
- Varghese, O. P., Liu, J., Sundaram, K., Hilborn, J. and Oommen, O. P. 2016. Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery.. Biomaterials Science 4(9), pp. 1310-1313. (10.1039/c6bm00335d)
- Gurav, D., Varghese, O. P., Hamad, O. A., Nilsson, B., Hilborn, J. and Oommen, O. P. 2015. Chondroitin sulfate coated gold nanoparticles: a new strategy to resolve multidrug resistance and thromboinflammation. Chemical Communications 52(5), pp. 966-969. (10.1039/c5cc09215a)
Bywgraffiad
Derbyniais ei Ph.D. mewn cemeg organig gan Sefydliad Technoleg India-Bombay yn 2010, lle canolbwyntiodd fy ymchwil ar ddatblygu methodolegau arloesol ar gyfer adweithiau organig. Symudais i Brifysgol Uppsala, Sweden i ddilyn fy hyfforddiant ôl-ddoethurol ym maes meddygaeth adfywiol. Profodd y profiad hwn yn amhrisiadwy gan iddo ehangu fy ngwybodaeth y tu hwnt i gemeg organig a'm galluogi i gaffael hyfedredd mewn gwahanol dechnegau biotechnoleg. Canolbwyntiais ar ddatblygu hydrogeliau arloesol ar gyfer adfywio esgyrn, gan ysgogi ei gefndir mewn synthesis organig i deilwra deunyddiau newydd a strategaethau bioconjugation newydd arloesol. Wedi'i ysgogi gan fy niddordeb mewn astudiaethau gwrthganser, cychwynnais linell ymchwil annibynnol, yn ystod y cyfnod hwn, gan arbenigo mewn dylunio systemau cyflenwi cyffuriau newydd.
Yn 2016, ymunais â Phrifysgol Tampere (Cyfadran Meddygaeth a Thechnoleg Iechyd) fel Athro Cynorthwyol ar drac deiliadaeth. Sefydlais y grŵp Biobeirianneg a Nanofeddygaeth, sy'n harneisio pŵer trawsnewidiol cemeg organig i fynd i'r afael â heriau biolegol amrywiol. Cefais fy nyrchafu yn Athro Cyswllt ym mis Awst 2020. Ym mis Gorffennaf 2024, ymunais â Phrifysgol Caerdydd yn yr Ysgol Fferylliaeth a Gwyddorau Fferyllol.
Rwy'n arwain tîm amlddisgyblaethol o gemegwyr, biolegwyr moleciwlaidd, a gwyddonwyr materol. Rwy'n gweithio yn y rhyngwyneb cemeg-bioleg ac mae fy ymchwil yn cynnwys biomaterials, nanofeddygaeth, peirianneg meinwe, a pheirianneg celloedd. Rwyf wedi sefydlu cydweithrediadau helaeth â gwyddonwyr blaenllaw yn Ewrop a Japan ac yn cymryd rhan mewn sawl prosiect cydweithredol. Ysgrifennais sawl erthygl a adolygwyd gan gymheiriaid a phenodau llyfrau a ffeilio tri patentau. Rwy'n gyd-sylfaenydd deillio o'r enw 'Uppsala Therapeutics AB' sy'n canolbwyntio ar notherapeutics ar gyfer cyflenwi ymennydd a chyflenwi asid niwclëig.
Safleoedd academaidd blaenorol
- 2024– present, Darlithydd, Prifysgol Caerdydd, yr Ysgol Fferylliaeth a Gwyddoniaeth Fferyllol, Caerdydd, y DU.
- Awst 2020 – Mehefin 2024 Athro Cyswllt (tenure-track); Prifysgol Tampere; Cyfadran Meddygaeth a Thechnoleg Iechyd, Korkeakoulunkatu 3, Tampere, Y Ffindir.
- Medi 2016 – Gorffennaf 2020, Athro Cynorthwyol (tenure-track); Prifysgol Tampere, Y Ffindir.
- Ionawr 2013-Awst 2016, Forskare (Uwch Ymchwilydd), Adran Cemeg, Labordy Ångström, Prifysgol Uppsala, Sweden.
- Ebrill 2011-Rhag 2012, Cymrawd Ôl-ddoethurol, Adran Cemeg, Labordy Ångström, Prifysgol Uppsala, Sweden. Mentor: Yr Athro Jöns Hilborn
Pwyllgorau ac adolygu
●Golygydd Cyswllt, Frontiers in Bioengineering a Biotechnology.
●Aelod o fwrdd golygyddol y cyfnodolyn 'Frontiers in Nanotechnology'.
●Aelod o'r Bwrdd Cynghori Rhyngwladol ar gyfer prosiect ERA-Cadeirydd H2020 TRANSCEND-IRO (ESEI-BioMed) -Romania (2020-2026).
●adolygydd arbenigol o bell ar gyfer Grant Dechrau ERC (Panel PE11; 2021)
●Adolygydd grant arbenigol ar gyfer 'Cymrodoriaeth Ôl-ddoethurol Ymddiriedolaeth Croeso Syr Henry', y DU. (2021)
●Aelod o'r Bwrdd Cynghori Gwyddonol, Cymdeithas Ewropeaidd Biomaterials
●Aelod o fwrdd gwyddonol o Bennod Ewropeaidd Cyfarfod y Gymdeithas Ryngwladol Peirianneg ac Adfywio Meinwe
●adolygydd grant arbenigol yn 'Disgyblaeth ar gyfer Gwyddorau Ffisegol a Pheirianneg' ar gyfer y Ganolfan Wyddoniaeth Genedlaethol, Gwlad Pwyl (2016-2018)
●Adolygydd ar gyfer y cyfnodolion a adolygir gan gymheiriaid canlynol: Biomaterials, Advanced Functional Materials; Biomacromoleciwlau; Deunyddiau a Rhyngwyneb Cymhwysol ACS; Adroddiadau gwyddonol; Acta Biomaterialia; Cyfathrebu Cemegol; Bach; Nanoraddfa; J. Mat. Chem. B; ayyb. https://www.webofscience.com/wos/author/record/152499
●2016- Trefnu Aelod Pwyllgor a Bwrdd Cynghori Gwyddonol, TERMIS Ewrop 2016 / Uppsala / Sweden
●Mai 2012 Trefnu Aelod Pwyllgor a Sesiwn Cadeirydd / 22nd Cynhadledd Ymchwil Rhyngddisgyblaethol ar Biomaterials, 'GRIBOI' / Prifysgol Uppsala / Sweden
Contact Details
Adeilad Redwood , Llawr 1, Ystafell 1.07, Rhodfa'r Brenin Edward VII, Caerdydd, CF10 3NB
Themâu ymchwil
Arbenigeddau
- Therapïau Uwch
- Biomaterialau
- Peirianneg biofeddygol
- cancr
- Therapi canser