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Oommen Oommen

Dr Oommen Oommen

(he/him)

Lecturer

Overview

I am trained as an organic chemist but have always been driven by a deep interest in biology. My research is centred on leveraging the power of synthetic chemistry to tackle complex biomedical challenges. Our group harnesses extracellular matrix -derived polymers such as hyaluronic acid and collagen and synthetic polymers to develop ECM mimetic 3D scaffolds, design functional nanomaterials and use these polymers to engineer stem cell engineering.

The hydrogel scaffolds are designed to mimic the natural tissue microenvironment, playing a critical role in modulating stem cell differentiation or macrophage polarization, which is essential for effective tissue regeneration. We are currently developing advanced tissue-mimetic hydrogel scaffolds for a variety of applications, including: (i) modelling tumour microenvironments (such as brain and prostate cancer models), (ii) creating bioinks for 3D bioprinting, and (iii) delivering stem cells or growth factors to aid in tissue regeneration (targeting tissues like cardiac, bone, cornea, and neuronal regeneration).

In addition to hydrogel scaffolds, our research utilise these biopolymers to design innovative nanomaterials, such as gold nanoparticles, iron oxide nanoparticles, and polymeric micelles, which capitalize on their immunomodulatory properties. These biopolymer-derived nanoparticles enhance blood circulation time, provide stealth characteristics, and reduce off-target effects, and target specific receptors such as CD44 and EGFR that are overexpressed on several solid tumours making them highly effective for targeted drug or gene delivery applications. One of the primary goals of my research is to develop drug delivery systems for targeting the brain to treat neurological diseases and for targeting prostate cancer. The Bioengineering and Nanomedicine, is founded upon cutting-edge multi-disciplinary research in the areas of biomaterials, tissue engineering, drug delivery, nanomedicine, cell-based therapy, and immunotherapy.

Publication

2025

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

Articles

Biography

I received his Ph.D. in organic chemistry from the Indian Institute of Technology-Bombay in 2010, where my research focused on developing innovative methodologies for organic reactions. I moved to Uppsala University, Sweden to pursue my Post Doctoral training in the field of regenerative medicine. This experience proved invaluable as it expanded my knowledge beyond organic chemistry and enabled me to acquire proficiency in various biotechnology techniques. I focused on developing innovative hydrogels for bone regeneration, leveraging his background in organic synthesis to tailor novel materials and pioneer novel bioconjugation strategies. Motivated by my interest in anticancer studies, I initiated an independent line of research, during this time, specializing in the design of novel drug delivery systems.

In 2016, I joined Tampere University (Faculty of Medicine and Health Technology) as a tenure-track Assistant Professor. I established the Bioengineering and Nanomedicine group, which harnesses the transformative power of organic chemistry to address diverse biological challenges. I was promoted to Associate Professor in August 2020. In July 2024, I joined Cardiff University at the School of Pharmacy and Pharmaceutical Sciences.

I lead a multidisciplinary team of chemists, molecular biologists, and material scientists. I work at the chemistry-biology interface and my research involve biomaterials, nanomedicine, tissue engineering, and cell engineering. I have established extensive collaborations with leading scientists in Europe and Japan and participate in several collaborative projects. I authored several peer-reviewed articles and book chapters and filed three patents. I am a co-founder of a spin-off called ‘Uppsala Therapeutics AB’ that focuses on nanotherapeutics for brain delivery and nucleic acid delivery.

Academic positions

  • 2024– present, Lecturer, Cardiff University, School of Pharmacy and Pharmaceutical Science, Cardiff, UK.
  • Aug. 2020 – June 2024 Associate Professor (tenure-track); Tampere University; Faculty of Medicine and Health Technology, Korkeakoulunkatu 3, Tampere, Finland.
  • Sept. 2016 – July 2020, Assistant Professor (tenure-track); Tampere University, Finland.
  • Jan 2013-Aug 2016, Forskare (Senior Researcher), Department of Chemistry, Ångström Laboratory, Uppsala University, Sweden.
  • April 2011-Dec 2012, Postdoctoral Fellow, Department of Chemistry, Ångström Laboratory, Uppsala University, Sweden. Mentor: Prof. Jöns Hilborn

Committees and reviewing

   Associate Editor, Frontiers in Bioengineering and Biotechnology.

   Editorial board member of the journal ‘Frontiers in Nanotechnology’.

  International Advisory Board Member for H2020 ERA-Chair project TRANSCEND-IRO (ESEI-BioMed)-Romania (2020-2026).

   Remote expert reviewer for ERC Starting Grant (PE11 Panel; 2021)

   Expert grant reviewer for ‘Sir Henry Welcome Trust Post-Doctoral Fellowship’, UK. (2021)

   Scientific Advisory Board Member, European Society of Biomaterials

  Scientific board member of European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society

   Expert grant reviewer in ‘Discipline for Physical Sciences and Engineering’ for the National Science Center, Poland (2016-2018)

● Reviewer for the following peer reviewed journals: Biomaterials, Advanced Materials, Advanced Functional Materials; Biomacromolecules; ACS Applied Materials and Interface; Scientific Reports; Acta Biomaterialia; Chemical Communications; Small; Nanoscale; J. Mat. Chem. B; etc. https://www.webofscience.com/wos/author/record/152499

    2016- Organizing Committee Member and Scientific Advisory Board, TERMIS Europe 2016/ Uppsala/ Sweden

  May 2012 Organizing Committee Member and Sessions Chair/ 22nd Interdisciplinary Research Conference on Biomaterials, ‘GRIBOI’/ Uppsala University/ Sweden

Contact Details

Email OommenO@cardiff.ac.uk

Campuses Redwood Building, Floor 1, Room 1.07, King Edward VII Avenue, Cardiff, CF10 3NB

Specialisms

  • advanced therapies
  • Biomaterials
  • Biomedical engineering
  • cancer
  • Cancer therapy