Ewch i’r prif gynnwys
Fabrizio Pertusati

Dr Fabrizio Pertusati


Ysgol Cemeg

Ar gael fel goruchwyliwr ôl-raddedig

















Adrannau llyfrau





The research in the group is mainly in synthetic organic chemistry aimed to solve a range of medicinal chemistry problems in the area of:

Rare Diseases

  • Lysosomal Storage diseases: cystinosys, Nieman-Pick, Mucolipidoses IV.

Inborn errors of metabolism

  • Synthesis of carbohydrate based compounds for the treatment of congenital disorder of glycosylation.
  • Nucleoside derivative for the treatment of Mitocondrial Depletion Syndrome.

Infectious diseases

  • Synthesis of nucleosides and non nucleoside scaffolds as novel antibacterial agents.
  • Fluorinated heterocycles as anti-biofilm and antimicrobial agents.
  • Fluorinated small molecules as novel antileishmaniasys drugs.

Synthetic Chemistry

-Synthesis of new acyclic nucleoside phosphate and phosphonate scaffolds as antiviral, anticancer and antibacterial drugs.

-Development of synthetic methodologies for the diasteroselective and enantioselective preparation of organophosphorus compounds via P(V) and P(III) chemistries.


Rare Diseases:

  • Dr Emyr Lloyd Evans (Lysosomal storage disease, School of Bioscience)
  • Professor Hudson Freeze (Congenital Disorder of Glycosylation, Sanford Burnham Institute, California)
  • Professor Michael W. Lawlor (Mitochondrial Depletion Syndrome, Medical College of Wisconsin)

Infectious diseases

Antibacterial and antibiofilm.


PH1125: Chemical and Biological Properties of Drug Molecules ( Module leader)

PH2114: Principles of Drug Design and Drug Disposition

PH3101: Optimisation of Drug Design

PH4116: Pharmacy Research or Scholarship Project

At the Cardiff School of Chemistry (2018-2020):

  • CH0003 Chemistry of organic compounds
  • CH4207 Intoduction to the chemistry of life
  • CHT354 Drug Development from Laboratory to Clinic
  • CHT216 Colloquium


I obtained my MSc degree in physical organic chemistry from Turin University (synthesis and characterisation of cationic surfactants). After three years spent in PCB industry as formulator scientist, I obtained my PhD in synthetic organic chemistry (Cardiff School of Chemistry, atropisomeric bis-quinazolinones as chiral auxiliaries for asymmetric synthesis). I conducted my post-doctoral training at Emory University (solid-phase synthesis of polymethine dyes) and in the laboratory of the Nobel laureate Prof. George Olah, at the University of Southern California (organofluorine, organoboron and polymer chemistry).

Since 2011, I have been working in Chris McGuigan’s group where I was involved in various medicinal chemistry projects spanning from diastereoselective synthesis of nucleosides (cyclic and acyclic) phosphoroamidate prodrugs, to fluorinated androgen-receptors antagonist for prostate cancer treatment, and design and synthesis of novel compounds acting on the Central Nervous System).

In 2016, I was promoted to Research Fellow in medicinal chemistry. My current research interests are in the synthesis of novel fluorinated antibiotics for the treatment of Gram-positive bacterial infections and biofilm formation (in collaboration with prof. Hans Steenackers at Leuven University) and in congenital disorders of glycosylation. I am also interested in drug design for the treatment of lysosomal storage disorders (Niemann-Pick, Huntington) in collaboration with Dr. Lloyd-Evans (Cardiff School of Bioscience).

Aelodaethau proffesiynol

  • Member of Scientific Advisory Board of Ichorion Therapeutics (2017-2018)
  • Member of Glycobiology Society

Pwyllgorau ac adolygu

  • Reviewer for The following Journal.

Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, The journal of Organic Chemistry, ChemMedChem, Molecules, Bioorganic & Medicinal Chemistry Letters, Journal of Fluorine Chemistry, Organic Letters and Dyes and Pigments.

  • Grant Reviewer: MRC-fellowship.