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Trosolwyg
Mae Dr Protty yn gofrestrydd clinigol academaidd WCAT mewn cardioleg sydd â diddordeb mewn llid (adwaith corfforol i lidwyr niweidiol), thrombosis a haemostasis (ffurfio ceuladau mewn iechyd a chlefydau), gan ei fod yn ymwneud â chleifion sy'n dioddef o gyflyrau'r galon.
Cwblhaodd ei PhD yng Ngrŵp Lipidomeg Caerdydd yn 2021, a ariannwyd gan gymrodoriaeth Ymddiriedolaeth Wellcome GW4CAT. Gan barhau o'i PhD, mae Dr Protty yn darlunio'r rôl y mae ffosffolipidau procoagulaidd llidiol yn ei chwarae mewn thrombosis arterial (e.e. trawiadau ar y galon) a gefnogir gan Grant Cychwynnol ar gyfer Darlithwyr Clinigol o Academi'r Gwyddorau Meddygol.
Cyhoeddiad
2025
- Ghorasaini, M., Costa, D., Tyrrell, V. J., Protty, M., Giera, M. and O'Donnell, V. B. 2025. A method for analysis of oxidized phospholipids from biological samples using mass spectrometry. In: Giera, M. and Sánchez-López, E. eds. Methods in Molecular Biology., Vol. 2855. New York, NY, USA: Springer, pp. 155-169., (10.1007/978-1-0716-4116-3_10)
2024
- Protty, M. B. et al. 2024. Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in atherosclerotic cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 44(9), pp. 2038-2052. (10.1161/ATVBAHA.124.320902)
- Elwood, P. et al. 2024. Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against. British Journal of Cancer 130, pp. 3-8. (10.1038/s41416-023-02506-5)
- Hajeyah, A. A. et al. 2024. Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease.. Journal of Lipid Research 65(1), article number: 100484. (10.1016/j.jlr.2023.100484)
2023
- Protty, M. and Ionescu, A. 2023. The devastating impact of artificial intelligence (AI) on the traditional ways of practising imaging and cardiology are 'imagers' an endangered species, and should trainees rethink their careers?. Romanian Journal of Cardiology 33(4), pp. 134-137. (10.2478/rjc-2023-0023)
- Protty, M., Hussain, H., Hailan, A. and Choudhury, A. 2023. DIRO: Useful comparative trial on rotational vs orbital atherectomy, but there are caveats [Letter to the Editor]. JACC: Cardiovascular Interventions 16(23), article number: 2935. (10.1016/j.jcin.2023.10.008)
- Protty, M. B. et al. 2023. Predictors of 1- and 12-month mortality in bifurcation coronary intervention: a contemporary perspective. Future Cardiology 0(0) (10.2217/fca-2023-0058)
- Protty, M. B., Dissanayake, T., Jeffery, D., Hailan, A. and Choudhury, A. 2023. Stent failure: the diagnosis and management of intracoronary stent restenosis. Expert Review of Cardiovascular Therapy 21(7), pp. 501-506. (10.1080/14779072.2023.2221852)
- Kinnaird, T. et al. 2023. Temporal trends in in-hospital outcomes following unprotected left-main percutaneous coronary intervention: an analysis of 14 522 cases from British cardiovascular intervention society database 2009 to 2017. Circulation: Cardiovascular Interventions 16(1), article number: e012350. (10.1161/CIRCINTERVENTIONS.122.012350)
2022
- Carande, E. J. et al. 2022. Predictors of 30 day and 12 month mortality in left main stem percutaneous coronary intervention 2016-2020: a study from two UK centers. Catheterization and Cardiovascular Interventions 100(4), pp. 585-592. (10.1002/ccd.30400)
- Elwood, P., Protty, M., Morgan, G., Pickering, J., Delon, C. and Watkins, J. 2022. Aspirin and cancer: biological mechanisms and clinical outcomes. Open Biology 12(9), article number: 220124. (10.1098/rsob.220124)
- Galusko, V., Protty, M., Haboubi, H. N., Verhemel, S., Bundhoo, S. and Yeoman, A. D. 2022. Endoscopy findings in patients on dual antiplatelet therapy following percutaneous coronary intervention. Postgraduate Medical Journal 98(1162), pp. 591-597. (10.1136/postgradmedj-2021-139928)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Protty, M. B., Jenkins, P. V., Collins, P. W. and O'Donnell, V. B. 2022. The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis. Open Biology 12(4), article number: 210318. (10.1098/rsob.210318)
- Poacher, A. T., Hoskins, H. C., Protty, M. B., Pettit, R. and Johansen, A. 2022. The impact of adopting low-molecular-weight heparin in place of aspirin as routine thromboprophylaxis for patients with hip fracture. Postgraduate Medical Journal, article number: 141628. (10.1136/postgradmedj-2022-141628)
- Mohee, K., Haboubi, H. N., Protty, M., Srinivasan, C., Townend, W. and Weston, C. 2022. Comparison of an e-learning package with lecture-based teaching in the management of supraventricular tachycardia (SVT): a randomised controlled study. Postgraduate Medical Journal 98(1157), pp. 187-192. (10.1136/postgradmedj-2020-139003)
- Protty, M. B. et al. 2022. The impact of intracoronary imaging on PCI outcomes in cases utilising rotational atherectomy: an analysis of 8,417 rotational atherectomy cases from the British Cardiovascular Intervention Society Database. Journal of Interventional Cardiology 2022, article number: 5879187. (10.1155/2022/5879187)
- Ding, W. Y., Protty, M. B., Davies, I. G. and Lip, G. Y. H. 2022. Relationship between lipoproteins, thrombosis and atrial fibrillation. Cardiovascular Research 118(3), pp. 716-731. (10.1093/cvr/cvab017)
- Protty, M. et al. 2022. Brachial arterial access for PCI: an analysis of the British Cardiovascular Intervention Society database. Eurointervention 17(13), pp. 1100-1103. (10.4244/EIJ-D-21-00294)
- Protty, M. et al. 2022. Defining percutaneous coronary intervention complexity and risk. JACC: Cardiovascular Interventions 15(1), pp. 39-49. (10.1016/j.jcin.2021.09.039)
2021
- Malik, N., Ahmed, J., Abdalla, B., Protty, M. and Haboubi, H. 2021. The status quo of gastroenterology training in the UK. The Lancet Gastroenterology & Hepatology 6(10), article number: 781. (10.1016/S2468-1253(21)00234-X)
- AL RAISI, S. et al. 2021. Ticagrelor versus prasugrel in acute coronary syndrome: sex-specific analysis from the RENAMI Registry. Minerva Cardiology and Angiology 69(4), pp. 408-416. (10.23736/S2724-5683.21.05591-5)
- Protty, M. B. et al. 2021. Rotational atherectomy complicated by coronary perforation is associated with poor outcomes: analysis of 10,980 cases from the British Cardiovascular Intervention Society database. Cardiovascular Revascularization Medicine 28, pp. 9-13. (10.1016/j.carrev.2020.07.040)
- Kinnaird, T. et al. 2021. Operator volumes and in-hospital outcomes: an analysis of 7,740 rotational atherectomy procedures from the BCIS national database. JACC: Cardiovascular Interventions 14(13), pp. 1423-1430. (10.1016/j.jcin.2021.04.034)
- Protty, M. B., Gallagher, S., Farooq, V., Sharp, A. S. P., Egred, M., O'Kane, P. and Kinnaird, T. 2021. Combined use of rotational and excimer lASER coronary atherectomy ( RASER ) during complex coronary angioplasty-An analysis of cases (2006-2016) from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(7), pp. E911-E918. (10.1002/ccd.29377)
- Protty, M. B., O'Neill, E. H. M., Kinnaird, T. and Gallagher, S. 2021. Case series of iatrogenic coronary stent avulsion: a rare complication with varied management strategies. European Heart Journal: Case Reports 5(5), article number: ytab181. (10.1093/ehjcr/ytab181)
- Protty, M. B. et al. 2021. Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(5), pp. E653-E660. (10.1002/ccd.29251)
- Hussain, H. I. et al. 2021. The impact of coronary perforation in percutaneous interventions involving the left main stem coronary artery in the United Kingdom 2007-2014: Insights from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(2), pp. E179-E185. (10.1002/ccd.28933)
- Elwood, P. C. et al. 2021. Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers. ecancermedicalscience 15, article number: 1258. (10.3332/ecancer.2021.1258)
- Protty, M. 2021. Characterising the role of inflammatory procoagulant phospholipids in arterial thrombosis. PhD Thesis, Cardiff University.
- Yin, W. L., Ahmed, A., Protty, M. B. and Ershaid, D. B. 2021. Review of implementation of the universal variable rate insulin infusion (VRII) chart introduced at the Royal Gwent Hospital based on Rowan Hillson Inpatient Safety Award 2019 (Joint British Diabetes Societies guidelines) [Abstract]. Diabetic Medicine 38(S1), article number: P86.
2020
- Elwood, P. C. et al. 2020. Better than any pill - and no side effects! Healthy lifestyles, statins and aspirin. Lifestyle Medecine 1(1), article number: e4. (10.1002/lim2.4)
- Galusko, V., Protty, M., Gilchrist, W., Bharucha, A., Bundhoo, S. and Cullen, J. 2020. The quest for a radial lounge: StatSeal™ reduces transradial coronary angiography turn-around time and cost [Letter]. Scandinavian Cardiovascular Journal 54(6), pp. 383-384. (10.1080/14017431.2020.1775879)
- Borna, S. et al. 2020. Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis. Journal of Cellular and Molecular Medicine 24(2), pp. 1980-1992. (10.1111/jcmm.14895)
2019
- Mohee, K., Protty, M. B., Whiffen, T., Chase, A. and Smith, D. 2019. Impact of social deprivation on outcome following transcatheter aortic valve implantation (TAVI). Open Heart 6(2), article number: e001089. (10.1136/openhrt-2019-001089)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
- Protty, M. B. 2019. Coronary artery disease and schizophrenia: the interplay of heart and mind. European Heart Journal - Quality of Care and Clinical Outcomes 5(2), pp. 90-91. (10.1093/ehjqcco/qcz005)
- Verhemel, S., Protty, M., Rodrigus, I., Paelinck, B. and Claeys, M. 2019. De-differentiated myxofibrosarcoma metastasis in the right atrium. JACC: Case Reports 1(2), pp. 151-155. (10.1016/j.jaccas.2019.06.021)
2018
- Protty, M. B., Wilkins, S. J., Hoskins, H. C., Dawood, B. B. and Hayes, J. 2018. Prescribing patterns of oral antiplatelets in Wales: evolving trends from 2005 to 2016. Future Cardiology 14(4), pp. 277-282. (10.2217/fca-2018-0003)
2017
- Protty, M. B., Mohee, K., Hoskins, H. C. and Haboubi, H. N. 2017. Securing a cardiology speciality training programme in the UK: how did other people do it?. Postgraduate Medical Journal 94(1109), pp. 155-158. (10.1136/postgradmedj-2017-135199)
- Protty, M., Haboubi, H., Yousuf, F., Yeoman, A., Jenkins, S. and Czajkowski, M. 2017. The liver as the homeostatic alarm: abnormal liver function tests precede the onset of diabetes mellitusby more than two years. Gut 66(S2), pp. A172. (10.1136/gutjnl-2017-314472.336)
- Protty, M., Smith, D., Lacey, A. and Freeman, P. 2017. Older (higher risk) patients with non-st-elevation acute coronary syndrome (NSTEACS) have the most to gain from invasive therapy: a population study in South Wales 2004–2014. Presented at: British Cardiovascular Society (BCS) Annual Conference 2017, Manchester, UK, 5–7 June 2017Heart, Vol. 103. BMJ Publishing Group pp. A48-A49., (10.1136/heartjnl-2017-311726.63)
- Protty, M. B., Lacey, A., Smith, D., Hannoodee, S. and Freeman, P. 2017. Increased morbidity, mortality and length of in-hospital stay for patients with acute coronary syndrome with pre-morbid psychiatric diagnoses. International Journal of Cardiology 236, pp. 5-8. (10.1016/j.ijcard.2017.01.067)
- Protty, M., Haboubi, H. and Yeoman, A. 2017. Changes in the Model for End-Stage Liver Disease (MELD) scores on day 7 predict mortality in acute on chronic liver disease: the delta-MELD project. Presented at: The International Liver Congress 2017, Amsterdam, Netherlands, 19-23 April 2017Journal of Hepatology, Vol. 66. Vol. S1. Elsevier pp. S387-S387., (10.1016/S0168-8278(17)31124-8)
- Protty, M. B. and Hayes, J. 2017. Dawn of the direct-acting oral anticoagulants: trends in oral anticoagulant prescribing in Wales 2009-2015. Journal of Clinical Pharmacy and Therapeutics 42(2), pp. 132-134. (10.1111/jcpt.12481)
- Protty, M. B., Lacey, A., Hayes, J. and Freeman, P. 2017. Statins for secondary prevention: clinical use in patients with acute coronary syndrome in Wales. Future Cardiology 13(2), pp. 137-141. (10.2217/fca-2016-0060)
2016
- Protty, M. B., Jaafar, M., Hannoodee, S. and Freeman, P. 2016. Acute coronary syndrome on Friday the 13th: a case for re-organising services?. The Medical Journal of Australia 205(11), pp. 523-525. (10.5694/mja16.00870)
- Freeman, P. M., Protty, M. B., Aldalati, O., Lacey, A., King, W., Anderson, R. and Smith, D. 2016. Severe symptomatic aortic stenosis: medical therapy and transcatheter aortic valve implantation (TAVI)- a real-world retrospective cohort analysis of outcomes and cost-effectiveness using national data. Open Heart 3(1), article number: e000414. (10.1136/openhrt-2016-000414)
- Protty, M. B., Lacey, A., Hayes, J. and Freeman, P. 2016. Statins for primary prevention in practice: clinical use in Wales and the NICE guideline effect [Letter]. British Journal of Clinical Pharmacology 82(3), pp. 892-894. (10.1111/bcp.13014)
2015
- Androshchuk, V., Protty, M. B., Freeman, P. M., Anderson, R. A., Kinnaird, T. and Ossei-Gerning, N. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: Transcatheter Cardiovascular Therapeutics 2015 (tct2015), San Francisco, USA, 11-15 October 2015Journal of the American College of Cardiology, Vol. 66. Vol. 15. Elsevier pp. B68-B68., (10.1016/j.jacc.2015.08.196)
- Androshchuk, V., Protty, M., Freeman, P. and Ossei-Gerning, N. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: British Cardiovascular Society (BCS) Annual Conference 2015, Manchester, UK, 8-10 June 2015, Vol. 101. BMJ Publishing Group pp. A68-A68., (10.1136/heartjnl-2015-308066.118)
- Protty, M. B., Aithal, S., Hickey, B., Pettit, R. and Johansen, A. 2015. The debate over mechanical thromboprophylaxis after hip fracture: time to choose sides. Presented at: British Geriatrics Society Autumn Meeting, Brighton, UK, 15–17 October 2014Age and Ageing, Vol. 44. Oxford University Press (OUP) pp. i12-i12., (10.1093/ageing/afv032.04)
- Protty, M., Freeman, P., Aldalati, O., Lacey, A., King, W., Anderson, R. and Smith, D. 2015. Severe symptomatic aortic stenosis: medical treatment versus Transcatheter Aortic Valve Implantation: a real world analysis of admission profiles, cost, and mortality using the Secure Anonymised Information Linkage (SAIL) databank. Presented at: American College of Cardiology / i2 Annual Scientific Session (ACC-i2), San Diego, USA, 14-16 March 2015Journal of the American College of Cardiology, Vol. 65. Vol. 10. Elsevier pp. A1867-A1867., (10.1016/S0735-1097(15)61867-8)
- Protty, M. B., Aithal, S., Hickey, B., Pettit, R. and Johansen, A. 2015. Mechanical prophylaxis after hip fracture: what is the risk of deep vein thrombosis? A retrospective observational study. BMJ Open 5(2), article number: e006956. (10.1136/bmjopen-2014-006956)
- Sako, Z., Hartery, K., Protty, M. B., Cheriyan, D. G., Harewood, G., Patchett, S. and Murray, F. 2015. Postal consent for gastrointestinal endoscopy: a patient based analysis. Presented at: Irish Society Of Gastroentrology Summer Meeting, Naas, Ireland, 12-13 June 2014, Vol. 184. Springer Verlag pp. S97-S98.
2013
- Protty, M. B., Mann, J., Mohammed, M. A., Holder, R. and Wiskin, C. 2013. Students as teachers: The impact of a near-peer-led didactic teaching model on tutee confidence. Medical Teacher 35(11), pp. 968. (10.3109/0142159X.2013.786814)
2009
- Mumford, A. D. et al. 2009. A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood 115(2), pp. 363-369. (10.1182/blood-2009-08-236976)
- Protty, M. et al. 2009. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochemical Journal 417(1), pp. 391-401. (10.1042/BJ20081126)
2008
- Orgel, J. P. et al. 2008. Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets. PLoS ONE 3(11), article number: e3793. (10.1371/journal.pone.0003793)
2007
- Dhanjal, T. S., Pendaries, C., Ross, E. A., Larson, M. K., Protty, M. B., Buckley, C. D. and Watson, S. P. 2007. A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood 109(10), pp. 4237-4244. (10.1182/blood-2006-10-050740)
Adrannau llyfrau
- Ghorasaini, M., Costa, D., Tyrrell, V. J., Protty, M., Giera, M. and O'Donnell, V. B. 2025. A method for analysis of oxidized phospholipids from biological samples using mass spectrometry. In: Giera, M. and Sánchez-López, E. eds. Methods in Molecular Biology., Vol. 2855. New York, NY, USA: Springer, pp. 155-169., (10.1007/978-1-0716-4116-3_10)
Cynadleddau
- Protty, M., Smith, D., Lacey, A. and Freeman, P. 2017. Older (higher risk) patients with non-st-elevation acute coronary syndrome (NSTEACS) have the most to gain from invasive therapy: a population study in South Wales 2004–2014. Presented at: British Cardiovascular Society (BCS) Annual Conference 2017, Manchester, UK, 5–7 June 2017Heart, Vol. 103. BMJ Publishing Group pp. A48-A49., (10.1136/heartjnl-2017-311726.63)
- Protty, M., Haboubi, H. and Yeoman, A. 2017. Changes in the Model for End-Stage Liver Disease (MELD) scores on day 7 predict mortality in acute on chronic liver disease: the delta-MELD project. Presented at: The International Liver Congress 2017, Amsterdam, Netherlands, 19-23 April 2017Journal of Hepatology, Vol. 66. Vol. S1. Elsevier pp. S387-S387., (10.1016/S0168-8278(17)31124-8)
- Androshchuk, V., Protty, M. B., Freeman, P. M., Anderson, R. A., Kinnaird, T. and Ossei-Gerning, N. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: Transcatheter Cardiovascular Therapeutics 2015 (tct2015), San Francisco, USA, 11-15 October 2015Journal of the American College of Cardiology, Vol. 66. Vol. 15. Elsevier pp. B68-B68., (10.1016/j.jacc.2015.08.196)
- Androshchuk, V., Protty, M., Freeman, P. and Ossei-Gerning, N. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: British Cardiovascular Society (BCS) Annual Conference 2015, Manchester, UK, 8-10 June 2015, Vol. 101. BMJ Publishing Group pp. A68-A68., (10.1136/heartjnl-2015-308066.118)
- Protty, M. B., Aithal, S., Hickey, B., Pettit, R. and Johansen, A. 2015. The debate over mechanical thromboprophylaxis after hip fracture: time to choose sides. Presented at: British Geriatrics Society Autumn Meeting, Brighton, UK, 15–17 October 2014Age and Ageing, Vol. 44. Oxford University Press (OUP) pp. i12-i12., (10.1093/ageing/afv032.04)
- Protty, M., Freeman, P., Aldalati, O., Lacey, A., King, W., Anderson, R. and Smith, D. 2015. Severe symptomatic aortic stenosis: medical treatment versus Transcatheter Aortic Valve Implantation: a real world analysis of admission profiles, cost, and mortality using the Secure Anonymised Information Linkage (SAIL) databank. Presented at: American College of Cardiology / i2 Annual Scientific Session (ACC-i2), San Diego, USA, 14-16 March 2015Journal of the American College of Cardiology, Vol. 65. Vol. 10. Elsevier pp. A1867-A1867., (10.1016/S0735-1097(15)61867-8)
- Sako, Z., Hartery, K., Protty, M. B., Cheriyan, D. G., Harewood, G., Patchett, S. and Murray, F. 2015. Postal consent for gastrointestinal endoscopy: a patient based analysis. Presented at: Irish Society Of Gastroentrology Summer Meeting, Naas, Ireland, 12-13 June 2014, Vol. 184. Springer Verlag pp. S97-S98.
Erthyglau
- Protty, M. B. et al. 2024. Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in atherosclerotic cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 44(9), pp. 2038-2052. (10.1161/ATVBAHA.124.320902)
- Elwood, P. et al. 2024. Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against. British Journal of Cancer 130, pp. 3-8. (10.1038/s41416-023-02506-5)
- Hajeyah, A. A. et al. 2024. Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease.. Journal of Lipid Research 65(1), article number: 100484. (10.1016/j.jlr.2023.100484)
- Protty, M. and Ionescu, A. 2023. The devastating impact of artificial intelligence (AI) on the traditional ways of practising imaging and cardiology are 'imagers' an endangered species, and should trainees rethink their careers?. Romanian Journal of Cardiology 33(4), pp. 134-137. (10.2478/rjc-2023-0023)
- Protty, M., Hussain, H., Hailan, A. and Choudhury, A. 2023. DIRO: Useful comparative trial on rotational vs orbital atherectomy, but there are caveats [Letter to the Editor]. JACC: Cardiovascular Interventions 16(23), article number: 2935. (10.1016/j.jcin.2023.10.008)
- Protty, M. B. et al. 2023. Predictors of 1- and 12-month mortality in bifurcation coronary intervention: a contemporary perspective. Future Cardiology 0(0) (10.2217/fca-2023-0058)
- Protty, M. B., Dissanayake, T., Jeffery, D., Hailan, A. and Choudhury, A. 2023. Stent failure: the diagnosis and management of intracoronary stent restenosis. Expert Review of Cardiovascular Therapy 21(7), pp. 501-506. (10.1080/14779072.2023.2221852)
- Kinnaird, T. et al. 2023. Temporal trends in in-hospital outcomes following unprotected left-main percutaneous coronary intervention: an analysis of 14 522 cases from British cardiovascular intervention society database 2009 to 2017. Circulation: Cardiovascular Interventions 16(1), article number: e012350. (10.1161/CIRCINTERVENTIONS.122.012350)
- Carande, E. J. et al. 2022. Predictors of 30 day and 12 month mortality in left main stem percutaneous coronary intervention 2016-2020: a study from two UK centers. Catheterization and Cardiovascular Interventions 100(4), pp. 585-592. (10.1002/ccd.30400)
- Elwood, P., Protty, M., Morgan, G., Pickering, J., Delon, C. and Watkins, J. 2022. Aspirin and cancer: biological mechanisms and clinical outcomes. Open Biology 12(9), article number: 220124. (10.1098/rsob.220124)
- Galusko, V., Protty, M., Haboubi, H. N., Verhemel, S., Bundhoo, S. and Yeoman, A. D. 2022. Endoscopy findings in patients on dual antiplatelet therapy following percutaneous coronary intervention. Postgraduate Medical Journal 98(1162), pp. 591-597. (10.1136/postgradmedj-2021-139928)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Protty, M. B., Jenkins, P. V., Collins, P. W. and O'Donnell, V. B. 2022. The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis. Open Biology 12(4), article number: 210318. (10.1098/rsob.210318)
- Poacher, A. T., Hoskins, H. C., Protty, M. B., Pettit, R. and Johansen, A. 2022. The impact of adopting low-molecular-weight heparin in place of aspirin as routine thromboprophylaxis for patients with hip fracture. Postgraduate Medical Journal, article number: 141628. (10.1136/postgradmedj-2022-141628)
- Mohee, K., Haboubi, H. N., Protty, M., Srinivasan, C., Townend, W. and Weston, C. 2022. Comparison of an e-learning package with lecture-based teaching in the management of supraventricular tachycardia (SVT): a randomised controlled study. Postgraduate Medical Journal 98(1157), pp. 187-192. (10.1136/postgradmedj-2020-139003)
- Protty, M. B. et al. 2022. The impact of intracoronary imaging on PCI outcomes in cases utilising rotational atherectomy: an analysis of 8,417 rotational atherectomy cases from the British Cardiovascular Intervention Society Database. Journal of Interventional Cardiology 2022, article number: 5879187. (10.1155/2022/5879187)
- Ding, W. Y., Protty, M. B., Davies, I. G. and Lip, G. Y. H. 2022. Relationship between lipoproteins, thrombosis and atrial fibrillation. Cardiovascular Research 118(3), pp. 716-731. (10.1093/cvr/cvab017)
- Protty, M. et al. 2022. Brachial arterial access for PCI: an analysis of the British Cardiovascular Intervention Society database. Eurointervention 17(13), pp. 1100-1103. (10.4244/EIJ-D-21-00294)
- Protty, M. et al. 2022. Defining percutaneous coronary intervention complexity and risk. JACC: Cardiovascular Interventions 15(1), pp. 39-49. (10.1016/j.jcin.2021.09.039)
- Malik, N., Ahmed, J., Abdalla, B., Protty, M. and Haboubi, H. 2021. The status quo of gastroenterology training in the UK. The Lancet Gastroenterology & Hepatology 6(10), article number: 781. (10.1016/S2468-1253(21)00234-X)
- AL RAISI, S. et al. 2021. Ticagrelor versus prasugrel in acute coronary syndrome: sex-specific analysis from the RENAMI Registry. Minerva Cardiology and Angiology 69(4), pp. 408-416. (10.23736/S2724-5683.21.05591-5)
- Protty, M. B. et al. 2021. Rotational atherectomy complicated by coronary perforation is associated with poor outcomes: analysis of 10,980 cases from the British Cardiovascular Intervention Society database. Cardiovascular Revascularization Medicine 28, pp. 9-13. (10.1016/j.carrev.2020.07.040)
- Kinnaird, T. et al. 2021. Operator volumes and in-hospital outcomes: an analysis of 7,740 rotational atherectomy procedures from the BCIS national database. JACC: Cardiovascular Interventions 14(13), pp. 1423-1430. (10.1016/j.jcin.2021.04.034)
- Protty, M. B., Gallagher, S., Farooq, V., Sharp, A. S. P., Egred, M., O'Kane, P. and Kinnaird, T. 2021. Combined use of rotational and excimer lASER coronary atherectomy ( RASER ) during complex coronary angioplasty-An analysis of cases (2006-2016) from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(7), pp. E911-E918. (10.1002/ccd.29377)
- Protty, M. B., O'Neill, E. H. M., Kinnaird, T. and Gallagher, S. 2021. Case series of iatrogenic coronary stent avulsion: a rare complication with varied management strategies. European Heart Journal: Case Reports 5(5), article number: ytab181. (10.1093/ehjcr/ytab181)
- Protty, M. B. et al. 2021. Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(5), pp. E653-E660. (10.1002/ccd.29251)
- Hussain, H. I. et al. 2021. The impact of coronary perforation in percutaneous interventions involving the left main stem coronary artery in the United Kingdom 2007-2014: Insights from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(2), pp. E179-E185. (10.1002/ccd.28933)
- Elwood, P. C. et al. 2021. Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers. ecancermedicalscience 15, article number: 1258. (10.3332/ecancer.2021.1258)
- Yin, W. L., Ahmed, A., Protty, M. B. and Ershaid, D. B. 2021. Review of implementation of the universal variable rate insulin infusion (VRII) chart introduced at the Royal Gwent Hospital based on Rowan Hillson Inpatient Safety Award 2019 (Joint British Diabetes Societies guidelines) [Abstract]. Diabetic Medicine 38(S1), article number: P86.
- Elwood, P. C. et al. 2020. Better than any pill - and no side effects! Healthy lifestyles, statins and aspirin. Lifestyle Medecine 1(1), article number: e4. (10.1002/lim2.4)
- Galusko, V., Protty, M., Gilchrist, W., Bharucha, A., Bundhoo, S. and Cullen, J. 2020. The quest for a radial lounge: StatSeal™ reduces transradial coronary angiography turn-around time and cost [Letter]. Scandinavian Cardiovascular Journal 54(6), pp. 383-384. (10.1080/14017431.2020.1775879)
- Borna, S. et al. 2020. Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis. Journal of Cellular and Molecular Medicine 24(2), pp. 1980-1992. (10.1111/jcmm.14895)
- Mohee, K., Protty, M. B., Whiffen, T., Chase, A. and Smith, D. 2019. Impact of social deprivation on outcome following transcatheter aortic valve implantation (TAVI). Open Heart 6(2), article number: e001089. (10.1136/openhrt-2019-001089)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
- Protty, M. B. 2019. Coronary artery disease and schizophrenia: the interplay of heart and mind. European Heart Journal - Quality of Care and Clinical Outcomes 5(2), pp. 90-91. (10.1093/ehjqcco/qcz005)
- Verhemel, S., Protty, M., Rodrigus, I., Paelinck, B. and Claeys, M. 2019. De-differentiated myxofibrosarcoma metastasis in the right atrium. JACC: Case Reports 1(2), pp. 151-155. (10.1016/j.jaccas.2019.06.021)
- Protty, M. B., Wilkins, S. J., Hoskins, H. C., Dawood, B. B. and Hayes, J. 2018. Prescribing patterns of oral antiplatelets in Wales: evolving trends from 2005 to 2016. Future Cardiology 14(4), pp. 277-282. (10.2217/fca-2018-0003)
- Protty, M. B., Mohee, K., Hoskins, H. C. and Haboubi, H. N. 2017. Securing a cardiology speciality training programme in the UK: how did other people do it?. Postgraduate Medical Journal 94(1109), pp. 155-158. (10.1136/postgradmedj-2017-135199)
- Protty, M., Haboubi, H., Yousuf, F., Yeoman, A., Jenkins, S. and Czajkowski, M. 2017. The liver as the homeostatic alarm: abnormal liver function tests precede the onset of diabetes mellitusby more than two years. Gut 66(S2), pp. A172. (10.1136/gutjnl-2017-314472.336)
- Protty, M. B., Lacey, A., Smith, D., Hannoodee, S. and Freeman, P. 2017. Increased morbidity, mortality and length of in-hospital stay for patients with acute coronary syndrome with pre-morbid psychiatric diagnoses. International Journal of Cardiology 236, pp. 5-8. (10.1016/j.ijcard.2017.01.067)
- Protty, M. B. and Hayes, J. 2017. Dawn of the direct-acting oral anticoagulants: trends in oral anticoagulant prescribing in Wales 2009-2015. Journal of Clinical Pharmacy and Therapeutics 42(2), pp. 132-134. (10.1111/jcpt.12481)
- Protty, M. B., Lacey, A., Hayes, J. and Freeman, P. 2017. Statins for secondary prevention: clinical use in patients with acute coronary syndrome in Wales. Future Cardiology 13(2), pp. 137-141. (10.2217/fca-2016-0060)
- Protty, M. B., Jaafar, M., Hannoodee, S. and Freeman, P. 2016. Acute coronary syndrome on Friday the 13th: a case for re-organising services?. The Medical Journal of Australia 205(11), pp. 523-525. (10.5694/mja16.00870)
- Freeman, P. M., Protty, M. B., Aldalati, O., Lacey, A., King, W., Anderson, R. and Smith, D. 2016. Severe symptomatic aortic stenosis: medical therapy and transcatheter aortic valve implantation (TAVI)- a real-world retrospective cohort analysis of outcomes and cost-effectiveness using national data. Open Heart 3(1), article number: e000414. (10.1136/openhrt-2016-000414)
- Protty, M. B., Lacey, A., Hayes, J. and Freeman, P. 2016. Statins for primary prevention in practice: clinical use in Wales and the NICE guideline effect [Letter]. British Journal of Clinical Pharmacology 82(3), pp. 892-894. (10.1111/bcp.13014)
- Protty, M. B., Aithal, S., Hickey, B., Pettit, R. and Johansen, A. 2015. Mechanical prophylaxis after hip fracture: what is the risk of deep vein thrombosis? A retrospective observational study. BMJ Open 5(2), article number: e006956. (10.1136/bmjopen-2014-006956)
- Protty, M. B., Mann, J., Mohammed, M. A., Holder, R. and Wiskin, C. 2013. Students as teachers: The impact of a near-peer-led didactic teaching model on tutee confidence. Medical Teacher 35(11), pp. 968. (10.3109/0142159X.2013.786814)
- Mumford, A. D. et al. 2009. A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood 115(2), pp. 363-369. (10.1182/blood-2009-08-236976)
- Protty, M. et al. 2009. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochemical Journal 417(1), pp. 391-401. (10.1042/BJ20081126)
- Orgel, J. P. et al. 2008. Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets. PLoS ONE 3(11), article number: e3793. (10.1371/journal.pone.0003793)
- Dhanjal, T. S., Pendaries, C., Ross, E. A., Larson, M. K., Protty, M. B., Buckley, C. D. and Watson, S. P. 2007. A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood 109(10), pp. 4237-4244. (10.1182/blood-2006-10-050740)
Gosodiad
- Protty, M. 2021. Characterising the role of inflammatory procoagulant phospholipids in arterial thrombosis. PhD Thesis, Cardiff University.
- Protty, M. B., Lacey, A., Smith, D., Hannoodee, S. and Freeman, P. 2017. Increased morbidity, mortality and length of in-hospital stay for patients with acute coronary syndrome with pre-morbid psychiatric diagnoses. International Journal of Cardiology 236, pp. 5-8. (10.1016/j.ijcard.2017.01.067)
- Protty, M. B., Jaafar, M., Hannoodee, S. and Freeman, P. 2016. Acute coronary syndrome on Friday the 13th: a case for re-organising services?. The Medical Journal of Australia 205(11), pp. 523-525. (10.5694/mja16.00870)
- Freeman, P. M., Protty, M. B., Aldalati, O., Lacey, A., King, W., Anderson, R. and Smith, D. 2016. Severe symptomatic aortic stenosis: medical therapy and transcatheter aortic valve implantation (TAVI)- a real-world retrospective cohort analysis of outcomes and cost-effectiveness using national data. Open Heart 3(1), article number: e000414. (10.1136/openhrt-2016-000414)
Ymchwil
Clefyd cardiofasgwlaidd (y galon) yw prif achos marwolaeth yn y DU. Mae cleifion â chlefyd y galon sy'n profi trawiad ar y galon mewn mwy o berygl o ddioddef trawiad ar y galon, strôc neu farwolaeth arall. Mae trawiadau ar y galon yn digwydd o ganlyniad i rwystrau mewn rhydwelïau ar y galon. Mae'r rhwystrau hyn yn cael eu hachosi gan lid (adwaith i llidus niweidiol) ac yn arwain at actifadu celloedd gwaed fel celloedd gwyn (sy'n gyfrifol am wella clwyfau) a phlatennau (sy'n gyfrifol am geulo gwaed) sydd yn ei dro yn arwain at geulo a rhwystrau annormal mewn rhydwelïau.
Mae ceulo gwaed yn digwydd trwy ryngweithio proteinau gwaed â brasterau penodol (ffosffolipidau) sy'n bresennol ar wyneb celloedd gwaed ac sy'n gysylltiedig â llid. Nid yw eu rôl bosibl wrth yrru digwyddiadau ceulo annormal mewn trawiadau ar y galon yn hysbys. Os caiff ei adnabod, gall fod yn driniaeth newydd bosibl. Mae hyn yn bwysig gan fod un o bob deg claf sy'n profi trawiad ar y galon yn parhau i fod mewn perygl o ddatblygu trawiad arall ar y galon, strôc, neu farw er gwaethaf y driniaeth bresennol.
Mae fy ymchwil yn canolbwyntio ar y proffil ffosffolipid a gynhyrchir gan gelloedd gwaed mewn cleifion â chlefyd y galon, gyda'r nod o adnabod gyrwyr ceulo yn y cleifion hyn, a datblygu targedau triniaeth newydd.
Addysgu
- Mentor/Goruchwyliwr ar gyfer Echocardiograffeg y Galon FUSIC (FICE / FUSIC) (2018-)
- Uwch Hyfforddwr Cynnal Bywyd (ALS), Cyngor Resus (DU) (2017-)
- Tiwtor Coleg Cyswllt (RCP), Bwrdd Iechyd Prifysgol Aneurin Bevan (2015-17)
- Aelod o'r Grŵp Ysgrifennu Cwestiwn (Blwyddyn 1/2) a'r Bwrdd Craffu Arholiadau (Blwyddyn 3), Prifysgol Caerdydd (2013-14)
Bywgraffiad
Dechreuodd ymrwymiad Dr Protty i feddygaeth academaidd pan oedd yn 18 oed. Gohiriodd ei gynnig i astudio meddygaeth am dair blynedd i weithio gyda Dr Mike Tomlinson (Birmingham) mewn labordy gwyddorau cardiofasgwlaidd sy'n arwain y byd dan arweiniad yr Athro Steve Watson (Birmingham) Sefydliad Prydeinig y Galon (BHF). O fewn y cyfnod hwn, ymchwiliodd Dr Protty i lwybrau signalau cymhleth platennau a'r rôl y maent yn ei chwarae mewn anhwylderau thrombotig a gwaedu.
Yn dilyn hyn, dechreuodd Dr Protty ei hyfforddiant meddygol ym Mhrifysgol Birmingham lle parhaodd i ddilyn cyfleoedd ymchwil. Enghraifft orau yw hyn drwy ennill Ysgoloriaeth Gwyliau Biofeddygol Ymddiriedolaeth Wellcome i gynnal ymchwil ar atamers RNA gwrth-HIV ym Mhrifysgol Rhydychen (Yr Athro William James). Graddiodd Dr Protty y cwrs MBChB (meddygaeth glinigol) yn 2013 gydag anrhydedd, tair rhagoriaeth a 15 gwobr genedlaethol a lleol.
Yn dilyn hynny, symudodd Dr Protty i Gymru yn dilyn ei benodiad i'r rhaglen sylfaen academaidd hynod gystadleuol yng Nghaerdydd. Yn ystod y cyfnod hwn, parhaodd â'i daith mewn cardioleg academaidd a dyfarnwyd gradd MSc (Prifysgol Caerdydd) iddo mewn therapiwteg therapiwteg gyda rhagoriaeth, gan astudio'r defnydd o therapi gostwng lipidau mewn cleifion sy'n dioddef o glefyd cardiofasgwlaidd yng Nghymru.
Dechreuodd Dr Protty ei hyfforddiant cardioleg arbenigol ar ôl cael ei benodi i gynllun Trac Academaidd Clinigol Cymru (WCAT) yn 2015. Fel rhan o'r cynllun hwn, datblygodd Dr Protty gysylltiadau â grŵp Lipidomeg Caerdydd (Yr Athro Valerie O'Donnell/Yr Athro Peter Collins) a gwnaeth gais llwyddiannus i gynllun GW4CAT Ymddiriedolaeth Wellcome i ddilyn gradd PhD (Dyfarnwyd 2021).
Gan barhau ar gynllun WCAT fel cofrestrydd cardioleg academaidd clnaidd, mae gweithgareddau ôl-ddoethurol Dr Protty yn canolbwyntio ar rôl ffosffolipidau procoagulant mewn thrombosis arterial gyda'r nod o nodi targedau therapiwtig gwrth-thrombotig newydd i wella gofal cleifion â chlefyd cardiofasgwlaidd.
Anrhydeddau a dyfarniadau
- 2017 Crynodeb Safle Uchaf yng nghategori ACS, Cynhadledd Flynyddol Cymdeithas Cardiofasgwlaidd Prydain
- Gwobr Ymchwil W T Edwards 2017, Cymdeithas Feddygol Caerdydd, Ebrill 2017
- Gwobr Ymchwilydd Ifanc 2017, Cyngres yr Afu Ryngwladol 2017, EASL
- Enillydd Gwobr y Canghellor 2013 – dyfernir y wobr glodfawr hon yn flynyddol i fyfyriwr aeddfed y mae ei gynnydd academaidd a'i berfformiad drwy gydol y cwrs wedi bod yn rhagorol ac sydd hefyd wedi gwneud cyfraniad rhagorol i fywyd cyffredinol y Brifysgol gyfan, Prifysgol Birmingham.
- 2013 Gwobr Israddedig BPS mewn Ffarmacoleg Glinigol, Cymdeithas Ffarmacolegol Prydain
- 2013 Enillydd Gwobr Goffa Arthur Foxwell mewn Meddygaeth – a ddyfarnwyd i'r myfyriwr sydd â'r sgôr uchaf mewn Meddygaeth Glinigol, Prifysgol Birmingham
- 2013 Cwpan y Gymdeithas Feddygol, Prifysgol Birmingham
- 2012 Ysgoloriaeth Teithio Dewisol Ymddiriedolaeth Myfyrwyr Meddygol a Deintyddol Prydain (BMDST)
- 2012 Ysgoloriaeth Teithio Dewisol Ymddiriedolaeth Arthur Thomson, Prifysgol Birmingham
- Gwobr Gyntaf 2011 am Wobr Leith Neumann mewn Astudiaethau Patholegol, Prifysgol Birmingham
- Gwobr 2011 am y cyflwyniad llafar gorau yn y sesiwn imiwnoleg yng Nghynhadledd Ryngwladol LIMSC, Prifysgol Leiden, NL
- 2010 Ysgoloriaeth Gwyliau Biofeddygol Ymddiriedolaeth Wellcome, i ariannu prosiect ymchwil ym Mhrifysgol Rhydychen.
Aelodaethau proffesiynol
- Cymdeithas Cardiofasgwlaidd Prydain (BCS)
- Cymdeithas Echocardiograffeg Prydain (BSE) - Achrediad llawn mewn ecocardiograffeg drawsthorasig
- Cymdeithas Ymyrraeth Cardiofasgwlaidd Prydain (BCIS) - Cyd-olygydd
- Cymdeithas Feddygol Prydain (BMA)
- General Medical Council (GMC)
- Coleg Brenhinol y Meddygon (MRCP Llundain)
- Aelod o'r Academi Addysgwyr Meddygol (MAcadMEd)
Pwyllgorau ac adolygu
- Aelod o Bwyllgor Staff Academaidd Meddygol y BMA (MASC), 2019-2021
- Cynrychiolydd Cymru i Gymdeithas Cardiolegwyr Iau Prydain (BJCA), 2020 -
- Adolygydd Grant - MRC, Wellcome 2018-
- Adolygydd Journal - Platennau, EHJ QCCO, BMJ Open, JACC, IJCP, Swyddogaeth
- Pwyllgor Addysg ar gyfer Hyfforddeion Meddyg, Bwrdd Iechyd Prifysgol Aneurin Bevan 2015-2017
Contact Details
ProttyM3@caerdydd.ac.uk
Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Ystafell Trydydd Llawr Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Ystafell Trydydd Llawr Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Themâu ymchwil
Arbenigeddau
- Cardioleg
- Clefydau cardiofasgwlaidd
- Lipids
- Thrombosis
- Platennau