![Majd Protty MBChB MRCP PgDip MSc PhD MAcadMEd](https://profiles-cardiff.imgix.net/attachments/2546?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Majd Protty
MBChB MRCP PgDip MSc PhD MAcadMEd
Cardiff Lipidomics Group
- ProttyM3@cardiff.ac.uk
- Sir Geraint Evans Cardiovascular Research Building, Room Third Floor of the Sir Geraint Evans Cardiovascular Research Building, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN
Overview
Dr Protty is a WCAT academic clinical registrar in cardiology with an interest in inflammation (bodily reaction to damaging irritants), thrombosis and haemostasis (clot formation in health and disease), as it relates to patients suffering from heart conditions.
He completed his PhD at the Cardiff Lipidomics Group in 2021, funded by the Wellcome Trust GW4CAT fellowship. Continuing from his PhD, Dr Protty is invesigating the role that inflammatory procoagulant phospholipids play in arterial thrombosis (e.g. heart attacks) supported by a Starter Grant for Clinical Lecturers from the Academy of Medical Sciences.
Publication
2024
- Hajeyah, A. A. et al. 2024. Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease.. Journal of Lipid Research 65(1), article number: 100484. (10.1016/j.jlr.2023.100484)
- Elwood, P. et al. 2024. Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against. British Journal of Cancer 130, pp. 3-8. (10.1038/s41416-023-02506-5)
2023
- Protty, M. and Ionescu, A. 2023. The devastating impact of artificial intelligence (AI) on the traditional ways of practising imaging and cardiology are 'imagers' an endangered species, and should trainees rethink their careers?. Romanian Journal of Cardiology 33(4), pp. 134-137. (10.2478/rjc-2023-0023)
- Protty, M., Hussain, H., Hailan, A. and Choudhury, A. 2023. DIRO: Useful comparative trial on rotational vs orbital atherectomy, but there are caveats [Letter to the Editor]. JACC: Cardiovascular Interventions 16(23), article number: 2935. (10.1016/j.jcin.2023.10.008)
- Protty, M. B. et al. 2023. Predictors of 1- and 12-month mortality in bifurcation coronary intervention: a contemporary perspective. Future Cardiology 0(0) (10.2217/fca-2023-0058)
- Protty, M. B., Dissanayake, T., Jeffery, D., Hailan, A. and Choudhury, A. 2023. Stent failure: the diagnosis and management of intracoronary stent restenosis. Expert Review of Cardiovascular Therapy 21(7), pp. 501-506. (10.1080/14779072.2023.2221852)
- Kinnaird, T. et al. 2023. Temporal trends in in-hospital outcomes following unprotected left-main percutaneous coronary intervention: an analysis of 14 522 cases from British cardiovascular intervention society database 2009 to 2017. Circulation: Cardiovascular Interventions 16(1), article number: e012350. (10.1161/CIRCINTERVENTIONS.122.012350)
2022
- Carande, E. J. et al. 2022. Predictors of 30 day and 12 month mortality in left main stem percutaneous coronary intervention 2016-2020: a study from two UK centers. Catheterization and Cardiovascular Interventions 100(4), pp. 585-592. (10.1002/ccd.30400)
- Elwood, P., Protty, M., Morgan, G., Pickering, J., Delon, C. and Watkins, J. 2022. Aspirin and cancer: biological mechanisms and clinical outcomes. Open Biology 12(9), article number: 220124. (10.1098/rsob.220124)
- Galusko, V., Protty, M., Haboubi, H. N., Verhemel, S., Bundhoo, S. and Yeoman, A. D. 2022. Endoscopy findings in patients on dual antiplatelet therapy following percutaneous coronary intervention. Postgraduate Medical Journal 98(1162), pp. 591-597. (10.1136/postgradmedj-2021-139928)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Protty, M. B., Jenkins, P. V., Collins, P. W. and O'Donnell, V. B. 2022. The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis. Open Biology 12(4), article number: 210318. (10.1098/rsob.210318)
- Poacher, A. T., Hoskins, H. C., Protty, M. B., Pettit, R. and Johansen, A. 2022. The impact of adopting low-molecular-weight heparin in place of aspirin as routine thromboprophylaxis for patients with hip fracture. Postgraduate Medical Journal, article number: 141628. (10.1136/postgradmedj-2022-141628)
- Mohee, K., Haboubi, H. N., Protty, M., Srinivasan, C., Townend, W. and Weston, C. 2022. Comparison of an e-learning package with lecture-based teaching in the management of supraventricular tachycardia (SVT): a randomised controlled study. Postgraduate Medical Journal 98(1157), pp. 187-192. (10.1136/postgradmedj-2020-139003)
- Protty, M. B. et al. 2022. The impact of intracoronary imaging on PCI outcomes in cases utilising rotational atherectomy: an analysis of 8,417 rotational atherectomy cases from the British Cardiovascular Intervention Society Database. Journal of Interventional Cardiology 2022, article number: 5879187. (10.1155/2022/5879187)
- Ding, W. Y., Protty, M. B., Davies, I. G. and Lip, G. Y. H. 2022. Relationship between lipoproteins, thrombosis and atrial fibrillation. Cardiovascular Research 118(3), pp. 716-731. (10.1093/cvr/cvab017)
- Protty, M. et al. 2022. Brachial arterial access for PCI: an analysis of the British Cardiovascular Intervention Society database. Eurointervention 17(13), pp. 1100-1103. (10.4244/EIJ-D-21-00294)
- Protty, M. et al. 2022. Defining percutaneous coronary intervention complexity and risk. JACC: Cardiovascular Interventions 15(1), pp. 39-49. (10.1016/j.jcin.2021.09.039)
2021
- Malik, N., Ahmed, J., Abdalla, B., Protty, M. and Haboubi, H. 2021. The status quo of gastroenterology training in the UK. The Lancet Gastroenterology & Hepatology 6(10), article number: 781. (10.1016/S2468-1253(21)00234-X)
- AL RAISI, S. et al. 2021. Ticagrelor versus prasugrel in acute coronary syndrome: sex-specific analysis from the RENAMI Registry. Minerva Cardiology and Angiology 69(4), pp. 408-416. (10.23736/S2724-5683.21.05591-5)
- Protty, M. B. et al. 2021. Rotational atherectomy complicated by coronary perforation is associated with poor outcomes: analysis of 10,980 cases from the British Cardiovascular Intervention Society database. Cardiovascular Revascularization Medicine 28, pp. 9-13. (10.1016/j.carrev.2020.07.040)
- Kinnaird, T. et al. 2021. Operator volumes and in-hospital outcomes: an analysis of 7,740 rotational atherectomy procedures from the BCIS national database. JACC: Cardiovascular Interventions 14(13), pp. 1423-1430. (10.1016/j.jcin.2021.04.034)
- Protty, M. B., Gallagher, S., Farooq, V., Sharp, A. S. P., Egred, M., O'Kane, P. and Kinnaird, T. 2021. Combined use of rotational and excimer lASER coronary atherectomy ( RASER ) during complex coronary angioplasty-An analysis of cases (2006-2016) from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(7), pp. E911-E918. (10.1002/ccd.29377)
- Protty, M. B., O'Neill, E. H. M., Kinnaird, T. and Gallagher, S. 2021. Case series of iatrogenic coronary stent avulsion: a rare complication with varied management strategies. European Heart Journal: Case Reports 5(5), article number: ytab181. (10.1093/ehjcr/ytab181)
- Protty, M. B. et al. 2021. Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(5), pp. E653-E660. (10.1002/ccd.29251)
- Hussain, H. I. et al. 2021. The impact of coronary perforation in percutaneous interventions involving the left main stem coronary artery in the United Kingdom 2007-2014: Insights from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(2), pp. E179-E185. (10.1002/ccd.28933)
- Protty, M. 2021. Characterising the role of inflammatory procoagulant phospholipids in arterial thrombosis. PhD Thesis, Cardiff University.
- Yin, W. L., Ahmed, A., Protty, M. B. and Ershaid, D. B. 2021. Review of implementation of the universal variable rate insulin infusion (VRII) chart introduced at the Royal Gwent Hospital based on Rowan Hillson Inpatient Safety Award 2019 (Joint British Diabetes Societies guidelines) [Abstract]. Diabetic Medicine 38(S1), article number: P86.
- Elwood, P. C. et al. 2021. Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers. ecancermedicalscience 15, article number: 1258. (10.3332/ecancer.2021.1258)
2020
- Elwood, P. C. et al. 2020. Better than any pill - and no side effects! Healthy lifestyles, statins and aspirin. Lifestyle Medecine 1(1), article number: e4. (10.1002/lim2.4)
- Galusko, V., Protty, M., Gilchrist, W., Bharucha, A., Bundhoo, S. and Cullen, J. 2020. The quest for a radial lounge: StatSeal™ reduces transradial coronary angiography turn-around time and cost [Letter]. Scandinavian Cardiovascular Journal 54(6), pp. 383-384. (10.1080/14017431.2020.1775879)
- Borna, S. et al. 2020. Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis. Journal of Cellular and Molecular Medicine 24(2), pp. 1980-1992. (10.1111/jcmm.14895)
2019
- Mohee, K., Protty, M. B., Whiffen, T., Chase, A. and Smith, D. 2019. Impact of social deprivation on outcome following transcatheter aortic valve implantation (TAVI). Open Heart 6(2), article number: e001089. (10.1136/openhrt-2019-001089)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
- Protty, M. B. 2019. Coronary artery disease and schizophrenia: the interplay of heart and mind. European Heart Journal - Quality of Care and Clinical Outcomes 5(2), pp. 90-91. (10.1093/ehjqcco/qcz005)
- Verhemel, S., Protty, M., Rodrigus, I., Paelinck, B. and Claeys, M. 2019. De-differentiated myxofibrosarcoma metastasis in the right atrium. JACC: Case Reports 1(2), pp. 151-155. (10.1016/j.jaccas.2019.06.021)
2018
- Protty, M. B., Wilkins, S. J., Hoskins, H. C., Dawood, B. B. and Hayes, J. 2018. Prescribing patterns of oral antiplatelets in Wales: evolving trends from 2005 to 2016. Future Cardiology 14(4), pp. 277-282. (10.2217/fca-2018-0003)
2017
- Protty, M. B., Mohee, K., Hoskins, H. C. and Haboubi, H. N. 2017. Securing a cardiology speciality training programme in the UK: how did other people do it?. Postgraduate Medical Journal 94(1109), pp. 155-158. (10.1136/postgradmedj-2017-135199)
- Protty, M., Haboubi, H., Yousuf, F., Yeoman, A., Jenkins, S. and Czajkowski, M. 2017. The liver as the homeostatic alarm: abnormal liver function tests precede the onset of diabetes mellitusby more than two years. Gut 66(S2), pp. A172. (10.1136/gutjnl-2017-314472.336)
- Protty, M., Smith, D., Lacey, A. and Freeman, P. 2017. Older (higher risk) patients with non-st-elevation acute coronary syndrome (NSTEACS) have the most to gain from invasive therapy: a population study in South Wales 2004–2014. Presented at: British Cardiovascular Society (BCS) Annual Conference 2017, Manchester, UK, 5–7 June 2017Heart, Vol. 103. BMJ Publishing Group pp. A48-A49., (10.1136/heartjnl-2017-311726.63)
- Protty, M. B., Lacey, A., Smith, D., Hannoodee, S. and Freeman, P. 2017. Increased morbidity, mortality and length of in-hospital stay for patients with acute coronary syndrome with pre-morbid psychiatric diagnoses. International Journal of Cardiology 236, pp. 5-8. (10.1016/j.ijcard.2017.01.067)
- Protty, M., Haboubi, H. and Yeoman, A. 2017. Changes in the Model for End-Stage Liver Disease (MELD) scores on day 7 predict mortality in acute on chronic liver disease: the delta-MELD project. Presented at: The International Liver Congress 2017, Amsterdam, Netherlands, 19-23 April 2017Journal of Hepatology, Vol. 66. Vol. S1. Elsevier pp. S387-S387., (10.1016/S0168-8278(17)31124-8)
- Protty, M. B. and Hayes, J. 2017. Dawn of the direct-acting oral anticoagulants: trends in oral anticoagulant prescribing in Wales 2009-2015. Journal of Clinical Pharmacy and Therapeutics 42(2), pp. 132-134. (10.1111/jcpt.12481)
- Protty, M. B., Lacey, A., Hayes, J. and Freeman, P. 2017. Statins for secondary prevention: clinical use in patients with acute coronary syndrome in Wales. Future Cardiology 13(2), pp. 137-141. (10.2217/fca-2016-0060)
2016
- Protty, M. B., Jaafar, M., Hannoodee, S. and Freeman, P. 2016. Acute coronary syndrome on Friday the 13th: a case for re-organising services?. The Medical Journal of Australia 205(11), pp. 523-525. (10.5694/mja16.00870)
- Freeman, P. M., Protty, M. B., Aldalati, O., Lacey, A., King, W., Anderson, R. and Smith, D. 2016. Severe symptomatic aortic stenosis: medical therapy and transcatheter aortic valve implantation (TAVI)- a real-world retrospective cohort analysis of outcomes and cost-effectiveness using national data. Open Heart 3(1), article number: e000414. (10.1136/openhrt-2016-000414)
- Protty, M. B., Lacey, A., Hayes, J. and Freeman, P. 2016. Statins for primary prevention in practice: clinical use in Wales and the NICE guideline effect [Letter]. British Journal of Clinical Pharmacology 82(3), pp. 892-894. (10.1111/bcp.13014)
2015
- Androshchuk, V., Protty, M. B., Freeman, P. M., Anderson, R. A., Kinnaird, T. and Ossei-Gerning, N. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: Transcatheter Cardiovascular Therapeutics 2015 (tct2015), San Francisco, USA, 11-15 October 2015Journal of the American College of Cardiology, Vol. 66. Vol. 15. Elsevier pp. B68-B68., (10.1016/j.jacc.2015.08.196)
- Androshchuk, V., Protty, M., Freeman, P. and Ossei-Gerning, N. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: British Cardiovascular Society (BCS) Annual Conference 2015, Manchester, UK, 8-10 June 2015, Vol. 101. BMJ Publishing Group pp. A68-A68., (10.1136/heartjnl-2015-308066.118)
- Protty, M. B., Aithal, S., Hickey, B., Pettit, R. and Johansen, A. 2015. The debate over mechanical thromboprophylaxis after hip fracture: time to choose sides. Presented at: British Geriatrics Society Autumn Meeting, Brighton, UK, 15–17 October 2014Age and Ageing, Vol. 44. Oxford University Press (OUP) pp. i12-i12., (10.1093/ageing/afv032.04)
- Protty, M., Freeman, P., Aldalati, O., Lacey, A., King, W., Anderson, R. and Smith, D. 2015. Severe symptomatic aortic stenosis: medical treatment versus Transcatheter Aortic Valve Implantation: a real world analysis of admission profiles, cost, and mortality using the Secure Anonymised Information Linkage (SAIL) databank. Presented at: American College of Cardiology / i2 Annual Scientific Session (ACC-i2), San Diego, USA, 14-16 March 2015Journal of the American College of Cardiology, Vol. 65. Vol. 10. Elsevier pp. A1867-A1867., (10.1016/S0735-1097(15)61867-8)
- Protty, M. B., Aithal, S., Hickey, B., Pettit, R. and Johansen, A. 2015. Mechanical prophylaxis after hip fracture: what is the risk of deep vein thrombosis? A retrospective observational study. BMJ Open 5(2), article number: e006956. (10.1136/bmjopen-2014-006956)
- Sako, Z., Hartery, K., Protty, M. B., Cheriyan, D. G., Harewood, G., Patchett, S. and Murray, F. 2015. Postal consent for gastrointestinal endoscopy: a patient based analysis. Presented at: Irish Society Of Gastroentrology Summer Meeting, Naas, Ireland, 12-13 June 2014, Vol. 184. Springer Verlag pp. S97-S98.
2013
- Protty, M. B., Mann, J., Mohammed, M. A., Holder, R. and Wiskin, C. 2013. Students as teachers: The impact of a near-peer-led didactic teaching model on tutee confidence. Medical Teacher 35(11), pp. 968. (10.3109/0142159X.2013.786814)
2009
- Mumford, A. D. et al. 2009. A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood 115(2), pp. 363-369. (10.1182/blood-2009-08-236976)
- Protty, M. et al. 2009. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochemical Journal 417(1), pp. 391-401. (10.1042/BJ20081126)
2008
- Orgel, J. P. et al. 2008. Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets. PLoS ONE 3(11), article number: e3793. (10.1371/journal.pone.0003793)
2007
- Dhanjal, T. S., Pendaries, C., Ross, E. A., Larson, M. K., Protty, M. B., Buckley, C. D. and Watson, S. P. 2007. A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood 109(10), pp. 4237-4244. (10.1182/blood-2006-10-050740)
Articles
- Hajeyah, A. A. et al. 2024. Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease.. Journal of Lipid Research 65(1), article number: 100484. (10.1016/j.jlr.2023.100484)
- Elwood, P. et al. 2024. Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against. British Journal of Cancer 130, pp. 3-8. (10.1038/s41416-023-02506-5)
- Protty, M. and Ionescu, A. 2023. The devastating impact of artificial intelligence (AI) on the traditional ways of practising imaging and cardiology are 'imagers' an endangered species, and should trainees rethink their careers?. Romanian Journal of Cardiology 33(4), pp. 134-137. (10.2478/rjc-2023-0023)
- Protty, M., Hussain, H., Hailan, A. and Choudhury, A. 2023. DIRO: Useful comparative trial on rotational vs orbital atherectomy, but there are caveats [Letter to the Editor]. JACC: Cardiovascular Interventions 16(23), article number: 2935. (10.1016/j.jcin.2023.10.008)
- Protty, M. B. et al. 2023. Predictors of 1- and 12-month mortality in bifurcation coronary intervention: a contemporary perspective. Future Cardiology 0(0) (10.2217/fca-2023-0058)
- Protty, M. B., Dissanayake, T., Jeffery, D., Hailan, A. and Choudhury, A. 2023. Stent failure: the diagnosis and management of intracoronary stent restenosis. Expert Review of Cardiovascular Therapy 21(7), pp. 501-506. (10.1080/14779072.2023.2221852)
- Kinnaird, T. et al. 2023. Temporal trends in in-hospital outcomes following unprotected left-main percutaneous coronary intervention: an analysis of 14 522 cases from British cardiovascular intervention society database 2009 to 2017. Circulation: Cardiovascular Interventions 16(1), article number: e012350. (10.1161/CIRCINTERVENTIONS.122.012350)
- Carande, E. J. et al. 2022. Predictors of 30 day and 12 month mortality in left main stem percutaneous coronary intervention 2016-2020: a study from two UK centers. Catheterization and Cardiovascular Interventions 100(4), pp. 585-592. (10.1002/ccd.30400)
- Elwood, P., Protty, M., Morgan, G., Pickering, J., Delon, C. and Watkins, J. 2022. Aspirin and cancer: biological mechanisms and clinical outcomes. Open Biology 12(9), article number: 220124. (10.1098/rsob.220124)
- Galusko, V., Protty, M., Haboubi, H. N., Verhemel, S., Bundhoo, S. and Yeoman, A. D. 2022. Endoscopy findings in patients on dual antiplatelet therapy following percutaneous coronary intervention. Postgraduate Medical Journal 98(1162), pp. 591-597. (10.1136/postgradmedj-2021-139928)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Protty, M. B., Jenkins, P. V., Collins, P. W. and O'Donnell, V. B. 2022. The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis. Open Biology 12(4), article number: 210318. (10.1098/rsob.210318)
- Poacher, A. T., Hoskins, H. C., Protty, M. B., Pettit, R. and Johansen, A. 2022. The impact of adopting low-molecular-weight heparin in place of aspirin as routine thromboprophylaxis for patients with hip fracture. Postgraduate Medical Journal, article number: 141628. (10.1136/postgradmedj-2022-141628)
- Mohee, K., Haboubi, H. N., Protty, M., Srinivasan, C., Townend, W. and Weston, C. 2022. Comparison of an e-learning package with lecture-based teaching in the management of supraventricular tachycardia (SVT): a randomised controlled study. Postgraduate Medical Journal 98(1157), pp. 187-192. (10.1136/postgradmedj-2020-139003)
- Protty, M. B. et al. 2022. The impact of intracoronary imaging on PCI outcomes in cases utilising rotational atherectomy: an analysis of 8,417 rotational atherectomy cases from the British Cardiovascular Intervention Society Database. Journal of Interventional Cardiology 2022, article number: 5879187. (10.1155/2022/5879187)
- Ding, W. Y., Protty, M. B., Davies, I. G. and Lip, G. Y. H. 2022. Relationship between lipoproteins, thrombosis and atrial fibrillation. Cardiovascular Research 118(3), pp. 716-731. (10.1093/cvr/cvab017)
- Protty, M. et al. 2022. Brachial arterial access for PCI: an analysis of the British Cardiovascular Intervention Society database. Eurointervention 17(13), pp. 1100-1103. (10.4244/EIJ-D-21-00294)
- Protty, M. et al. 2022. Defining percutaneous coronary intervention complexity and risk. JACC: Cardiovascular Interventions 15(1), pp. 39-49. (10.1016/j.jcin.2021.09.039)
- Malik, N., Ahmed, J., Abdalla, B., Protty, M. and Haboubi, H. 2021. The status quo of gastroenterology training in the UK. The Lancet Gastroenterology & Hepatology 6(10), article number: 781. (10.1016/S2468-1253(21)00234-X)
- AL RAISI, S. et al. 2021. Ticagrelor versus prasugrel in acute coronary syndrome: sex-specific analysis from the RENAMI Registry. Minerva Cardiology and Angiology 69(4), pp. 408-416. (10.23736/S2724-5683.21.05591-5)
- Protty, M. B. et al. 2021. Rotational atherectomy complicated by coronary perforation is associated with poor outcomes: analysis of 10,980 cases from the British Cardiovascular Intervention Society database. Cardiovascular Revascularization Medicine 28, pp. 9-13. (10.1016/j.carrev.2020.07.040)
- Kinnaird, T. et al. 2021. Operator volumes and in-hospital outcomes: an analysis of 7,740 rotational atherectomy procedures from the BCIS national database. JACC: Cardiovascular Interventions 14(13), pp. 1423-1430. (10.1016/j.jcin.2021.04.034)
- Protty, M. B., Gallagher, S., Farooq, V., Sharp, A. S. P., Egred, M., O'Kane, P. and Kinnaird, T. 2021. Combined use of rotational and excimer lASER coronary atherectomy ( RASER ) during complex coronary angioplasty-An analysis of cases (2006-2016) from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(7), pp. E911-E918. (10.1002/ccd.29377)
- Protty, M. B., O'Neill, E. H. M., Kinnaird, T. and Gallagher, S. 2021. Case series of iatrogenic coronary stent avulsion: a rare complication with varied management strategies. European Heart Journal: Case Reports 5(5), article number: ytab181. (10.1093/ehjcr/ytab181)
- Protty, M. B. et al. 2021. Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(5), pp. E653-E660. (10.1002/ccd.29251)
- Hussain, H. I. et al. 2021. The impact of coronary perforation in percutaneous interventions involving the left main stem coronary artery in the United Kingdom 2007-2014: Insights from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97(2), pp. E179-E185. (10.1002/ccd.28933)
- Yin, W. L., Ahmed, A., Protty, M. B. and Ershaid, D. B. 2021. Review of implementation of the universal variable rate insulin infusion (VRII) chart introduced at the Royal Gwent Hospital based on Rowan Hillson Inpatient Safety Award 2019 (Joint British Diabetes Societies guidelines) [Abstract]. Diabetic Medicine 38(S1), article number: P86.
- Elwood, P. C. et al. 2021. Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers. ecancermedicalscience 15, article number: 1258. (10.3332/ecancer.2021.1258)
- Elwood, P. C. et al. 2020. Better than any pill - and no side effects! Healthy lifestyles, statins and aspirin. Lifestyle Medecine 1(1), article number: e4. (10.1002/lim2.4)
- Galusko, V., Protty, M., Gilchrist, W., Bharucha, A., Bundhoo, S. and Cullen, J. 2020. The quest for a radial lounge: StatSeal™ reduces transradial coronary angiography turn-around time and cost [Letter]. Scandinavian Cardiovascular Journal 54(6), pp. 383-384. (10.1080/14017431.2020.1775879)
- Borna, S. et al. 2020. Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis. Journal of Cellular and Molecular Medicine 24(2), pp. 1980-1992. (10.1111/jcmm.14895)
- Mohee, K., Protty, M. B., Whiffen, T., Chase, A. and Smith, D. 2019. Impact of social deprivation on outcome following transcatheter aortic valve implantation (TAVI). Open Heart 6(2), article number: e001089. (10.1136/openhrt-2019-001089)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
- Protty, M. B. 2019. Coronary artery disease and schizophrenia: the interplay of heart and mind. European Heart Journal - Quality of Care and Clinical Outcomes 5(2), pp. 90-91. (10.1093/ehjqcco/qcz005)
- Verhemel, S., Protty, M., Rodrigus, I., Paelinck, B. and Claeys, M. 2019. De-differentiated myxofibrosarcoma metastasis in the right atrium. JACC: Case Reports 1(2), pp. 151-155. (10.1016/j.jaccas.2019.06.021)
- Protty, M. B., Wilkins, S. J., Hoskins, H. C., Dawood, B. B. and Hayes, J. 2018. Prescribing patterns of oral antiplatelets in Wales: evolving trends from 2005 to 2016. Future Cardiology 14(4), pp. 277-282. (10.2217/fca-2018-0003)
- Protty, M. B., Mohee, K., Hoskins, H. C. and Haboubi, H. N. 2017. Securing a cardiology speciality training programme in the UK: how did other people do it?. Postgraduate Medical Journal 94(1109), pp. 155-158. (10.1136/postgradmedj-2017-135199)
- Protty, M., Haboubi, H., Yousuf, F., Yeoman, A., Jenkins, S. and Czajkowski, M. 2017. The liver as the homeostatic alarm: abnormal liver function tests precede the onset of diabetes mellitusby more than two years. Gut 66(S2), pp. A172. (10.1136/gutjnl-2017-314472.336)
- Protty, M. B., Lacey, A., Smith, D., Hannoodee, S. and Freeman, P. 2017. Increased morbidity, mortality and length of in-hospital stay for patients with acute coronary syndrome with pre-morbid psychiatric diagnoses. International Journal of Cardiology 236, pp. 5-8. (10.1016/j.ijcard.2017.01.067)
- Protty, M. B. and Hayes, J. 2017. Dawn of the direct-acting oral anticoagulants: trends in oral anticoagulant prescribing in Wales 2009-2015. Journal of Clinical Pharmacy and Therapeutics 42(2), pp. 132-134. (10.1111/jcpt.12481)
- Protty, M. B., Lacey, A., Hayes, J. and Freeman, P. 2017. Statins for secondary prevention: clinical use in patients with acute coronary syndrome in Wales. Future Cardiology 13(2), pp. 137-141. (10.2217/fca-2016-0060)
- Protty, M. B., Jaafar, M., Hannoodee, S. and Freeman, P. 2016. Acute coronary syndrome on Friday the 13th: a case for re-organising services?. The Medical Journal of Australia 205(11), pp. 523-525. (10.5694/mja16.00870)
- Freeman, P. M., Protty, M. B., Aldalati, O., Lacey, A., King, W., Anderson, R. and Smith, D. 2016. Severe symptomatic aortic stenosis: medical therapy and transcatheter aortic valve implantation (TAVI)- a real-world retrospective cohort analysis of outcomes and cost-effectiveness using national data. Open Heart 3(1), article number: e000414. (10.1136/openhrt-2016-000414)
- Protty, M. B., Lacey, A., Hayes, J. and Freeman, P. 2016. Statins for primary prevention in practice: clinical use in Wales and the NICE guideline effect [Letter]. British Journal of Clinical Pharmacology 82(3), pp. 892-894. (10.1111/bcp.13014)
- Protty, M. B., Aithal, S., Hickey, B., Pettit, R. and Johansen, A. 2015. Mechanical prophylaxis after hip fracture: what is the risk of deep vein thrombosis? A retrospective observational study. BMJ Open 5(2), article number: e006956. (10.1136/bmjopen-2014-006956)
- Protty, M. B., Mann, J., Mohammed, M. A., Holder, R. and Wiskin, C. 2013. Students as teachers: The impact of a near-peer-led didactic teaching model on tutee confidence. Medical Teacher 35(11), pp. 968. (10.3109/0142159X.2013.786814)
- Mumford, A. D. et al. 2009. A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood 115(2), pp. 363-369. (10.1182/blood-2009-08-236976)
- Protty, M. et al. 2009. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochemical Journal 417(1), pp. 391-401. (10.1042/BJ20081126)
- Orgel, J. P. et al. 2008. Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets. PLoS ONE 3(11), article number: e3793. (10.1371/journal.pone.0003793)
- Dhanjal, T. S., Pendaries, C., Ross, E. A., Larson, M. K., Protty, M. B., Buckley, C. D. and Watson, S. P. 2007. A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood 109(10), pp. 4237-4244. (10.1182/blood-2006-10-050740)
Conferences
- Protty, M., Smith, D., Lacey, A. and Freeman, P. 2017. Older (higher risk) patients with non-st-elevation acute coronary syndrome (NSTEACS) have the most to gain from invasive therapy: a population study in South Wales 2004–2014. Presented at: British Cardiovascular Society (BCS) Annual Conference 2017, Manchester, UK, 5–7 June 2017Heart, Vol. 103. BMJ Publishing Group pp. A48-A49., (10.1136/heartjnl-2017-311726.63)
- Protty, M., Haboubi, H. and Yeoman, A. 2017. Changes in the Model for End-Stage Liver Disease (MELD) scores on day 7 predict mortality in acute on chronic liver disease: the delta-MELD project. Presented at: The International Liver Congress 2017, Amsterdam, Netherlands, 19-23 April 2017Journal of Hepatology, Vol. 66. Vol. S1. Elsevier pp. S387-S387., (10.1016/S0168-8278(17)31124-8)
- Androshchuk, V., Protty, M. B., Freeman, P. M., Anderson, R. A., Kinnaird, T. and Ossei-Gerning, N. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: Transcatheter Cardiovascular Therapeutics 2015 (tct2015), San Francisco, USA, 11-15 October 2015Journal of the American College of Cardiology, Vol. 66. Vol. 15. Elsevier pp. B68-B68., (10.1016/j.jacc.2015.08.196)
- Androshchuk, V., Protty, M., Freeman, P. and Ossei-Gerning, N. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: British Cardiovascular Society (BCS) Annual Conference 2015, Manchester, UK, 8-10 June 2015, Vol. 101. BMJ Publishing Group pp. A68-A68., (10.1136/heartjnl-2015-308066.118)
- Protty, M. B., Aithal, S., Hickey, B., Pettit, R. and Johansen, A. 2015. The debate over mechanical thromboprophylaxis after hip fracture: time to choose sides. Presented at: British Geriatrics Society Autumn Meeting, Brighton, UK, 15–17 October 2014Age and Ageing, Vol. 44. Oxford University Press (OUP) pp. i12-i12., (10.1093/ageing/afv032.04)
- Protty, M., Freeman, P., Aldalati, O., Lacey, A., King, W., Anderson, R. and Smith, D. 2015. Severe symptomatic aortic stenosis: medical treatment versus Transcatheter Aortic Valve Implantation: a real world analysis of admission profiles, cost, and mortality using the Secure Anonymised Information Linkage (SAIL) databank. Presented at: American College of Cardiology / i2 Annual Scientific Session (ACC-i2), San Diego, USA, 14-16 March 2015Journal of the American College of Cardiology, Vol. 65. Vol. 10. Elsevier pp. A1867-A1867., (10.1016/S0735-1097(15)61867-8)
- Sako, Z., Hartery, K., Protty, M. B., Cheriyan, D. G., Harewood, G., Patchett, S. and Murray, F. 2015. Postal consent for gastrointestinal endoscopy: a patient based analysis. Presented at: Irish Society Of Gastroentrology Summer Meeting, Naas, Ireland, 12-13 June 2014, Vol. 184. Springer Verlag pp. S97-S98.
Thesis
- Protty, M. 2021. Characterising the role of inflammatory procoagulant phospholipids in arterial thrombosis. PhD Thesis, Cardiff University.
- Protty, M. B., Lacey, A., Smith, D., Hannoodee, S. and Freeman, P. 2017. Increased morbidity, mortality and length of in-hospital stay for patients with acute coronary syndrome with pre-morbid psychiatric diagnoses. International Journal of Cardiology 236, pp. 5-8. (10.1016/j.ijcard.2017.01.067)
- Protty, M. B., Jaafar, M., Hannoodee, S. and Freeman, P. 2016. Acute coronary syndrome on Friday the 13th: a case for re-organising services?. The Medical Journal of Australia 205(11), pp. 523-525. (10.5694/mja16.00870)
- Freeman, P. M., Protty, M. B., Aldalati, O., Lacey, A., King, W., Anderson, R. and Smith, D. 2016. Severe symptomatic aortic stenosis: medical therapy and transcatheter aortic valve implantation (TAVI)- a real-world retrospective cohort analysis of outcomes and cost-effectiveness using national data. Open Heart 3(1), article number: e000414. (10.1136/openhrt-2016-000414)
Research
Cardiovascular (heart) disease is the number one cause of death in the UK. Patients with heart disease who experience a heart attack are at a higher risk of suffering another heart attack, stroke or death. Heart attacks happen as a result of blockages in heart arteries. These blockages are caused by inflammation (a reaction to a damaging irritant) and lead to activation of blood cells such as white cells (responsible for wound healing) and platelets (responsible for blood clotting) which in turn lead to abnormal clotting and blockages in arteries.
Blood clotting happens through interactions of blood proteins with particular fats (phospholipids) that are present on the surface of blood cells and are linked to inflammation. Their potential role in driving abnormal clotting events in heart attacks is unknown. If identified, it may serve as a potential new treatment. This is important since one in ten patients who experience a heart attack remain at risk of developing another heart attack, a stroke, or dying despite current treatment.
My research is focused on the phospholipid profile generated by blood cells in patients with heart disease, with the aim of identifying the drivers of clotting in these patients, and developing new treatment targets.
Teaching
- Mentor/Supervisor for FUSIC Heart Echocardiography (FICE/FUSIC) (2018-)
- Advanced Life Support (ALS) Instructor, Resus Council (UK) (2017-)
- Associate College (RCP) Tutor, Aneurin Bevan University Healthboard (2015-17)
- Member of the Question Writing Group (Year 1/2) and Exam Scrutiny Board (Year 3), Cardiff University (2013-14)
Biography
Dr Protty's commitment to academic medicine began when he was 18 years old. He deferred his offer to study medicine for three years to work with Dr Mike Tomlinson (Birmingham) in a world-leading cardiovascular sciences laboratory led by British Heart Foundation (BHF) Professor Steve Watson (Birmingham). Within this time, Dr Protty investigated the intricate signalling pathways of platelets and the role they play in thrombotic and bleeding disorders.
Following this, Dr Protty started his medical training at the University of Birmingham during which he continued to pursue research opportunities. This is best exemplified by being awarded a Wellcome Trust Biomedical Vacation Scholarship to carry out research on anti-HIV RNA aptamers at the University of Oxford (Prof William James). Dr Protty graduated the MBChB (clinical medicine) course in 2013 with honours, three distinctions and 15 national and local prizes.
Subsequently, Dr Protty moved to Wales following his appointment to the highly competitive academic foundation programme in Cardiff. During this time, he continued his journey in academic cardiology and was awarded an MSc degree (Cardiff University) in therapeutics with distinction, studying the use of lipid lowering therapy in patients suffering from cardiovascular disease in Wales.
Dr Protty started his specialist cardiology training after being appointed to the Wales Clinical Academic Track (WCAT) scheme in 2015. As part of this scheme, Dr Protty developed links with the Cardiff Lipidomics group (Prof Valerie O'Donnell/Prof Peter Collins) and successfully applied to the Wellcome Trust GW4CAT scheme to pursue a PhD degree (Awarded 2021).
Continuing on the WCAT scheme as a clnical academic cardiology registrar, Dr Protty's post-doctoral activities focus on the role of procoagulant phospholipids in arterial thrombosis with the aim of identifying novel anti-thrombotic therapeutic targets to improve the care of patients with cardiovascular disease.
Honours and awards
- 2017 Highest Ranking Abstract in ACS category, British Cardiovascular Society Annual Conference
- 2017 W T Edwards Research Prize, Cardiff Medical Society, Apr 2017
- 2017 Young Investigator Award, International Liver Congress 2017, EASL
- 2013 Chancellor’s Prize winner – this highly prestigious prize is awarded annually to a mature student whose academic progress and performance throughout the course have been outstanding and who has also made an outstanding contribution to the general life of the University as a whole, University of Birmingham.
- 2013 BPS Undergraduate prize in Clinical Pharmacology, British Pharmacological Society
- 2013 Arthur Foxwell Memorial Prize in Medicine winner – awarded to the highest scoring student in Clinical Medicine, University of Birmingham
- 2013 The Medical Society Cup, University of Birmingham
- 2012 British Medical and Dental Students Trust (BMDST) Elective Travel Scholarship
- 2012 Arthur Thomson Trust Elective Travel Scholarship, University of Birmingham
- 2011 First Prize for the Leith Neumann prize in Pathological studies, University of Birmingham
- 2011 Prize for best oral presentation in the immunology session at the LIMSC International Conference, Leiden University, NL
- 2010 The Wellcome Trust Biomedical Vacation Scholarship, to fund a research project at the University of Oxford.
Professional memberships
- British Cardiovascular Society (BCS)
- British Society of Echocardiography (BSE) - Full accreditation in transthoracic echocardiography
- British Cardiovascular Intervention Society (BCIS) - Fellow editor
- British Medical Association (BMA)
- General Medical Council (GMC)
- Member of the Royal College of Physicians (MRCP London)
- Member of the Academy of Medical Educators (MAcadMEd)
Committees and reviewing
- Member of the BMA Medical Academic Staff Committee (MASC), 2019-2021
- Wales Representative to the British Junior Cardiologists Association (BJCA), 2020-
- Grant Reviewer - MRC, Wellcome 2018-
- Journal Reviewer - Platelets, EHJ QCCO, BMJ Open, JACC, IJCP, Function
- Education committee for Physician trainees, Aneurin Bevan University Health Board 2015-2017
Research themes
Specialisms
- Cardiology
- Cardiovascular diseases
- Lipids
- Thrombosis
- Platelets