![Aled Rees MBBCh FRCP PhD](https://profiles-cardiff.imgix.net/attachments/2555?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Aled Rees
(e/fe)
MBBCh FRCP PhD
- Siarad Cymraeg
Timau a rolau for Aled Rees
Athro Clinigol
Trosolwg
Mae gen i ddiddordeb ymchwil clinigol a throsiadol mewn sawl agwedd ar endocrinoleg, gyda ffocws penodol ar endocrinoleg atgenhedlu, clefyd thyroid ac anhwylderau steroidau.
Mae fy astudiaethau cyfredol yn defnyddio cofnodion iechyd electronig, dadansoddiad genetig ac MRI uwch i ddeall effaith yr amgylchedd hormonaidd mewn bywyd cynnar ar ganlyniadau iechyd hirdymor. Mae fy ngrŵp wedi nodweddu canlyniadau metabolig, iechyd meddwl a cardiofasgwlaidd hirdymor cleifion â Syndrom Ofari Metabolig Polyendocrin (PMOS), ac wedi archwilio effaith PMOS ar ddefnyddio adnoddau iechyd a baich economaidd. Rydym wedi cynnal astudiaethau ffisiolegol i ddangos microstrwythur yr ymennydd, metaboledd a swyddogaeth cerebrofasgwlaidd wedi'i newid yn y boblogaeth hon, ac rydym yn archwilio'r potensial ar gyfer therapi ymarfer corff a blocâd androgen i addasu'r risgiau hyn. Arweiniais Bartneriaeth Gosod Blaenoriaethau Cynghrair James Lind a oedd yn rhestru'r blaenoriaethau ymchwil pwysicaf ar gyfer PMOS, ac rwy'n Ymgynghorydd Pwnc ar gyfer canllaw NICE.
Mae ein hastudiaeth ddilynol hirdymor o blant a anwyd i famau yn y treial Sgrinio Thyroid Cynenedigol dan Reolaeth (CATS) yn cynnwys MRI uwch a gynhaliwyd yng Nghanolfan Delweddu Ymchwil yr Ymennydd Prifysgol Caerdydd (CUBRIC) i archwilio effaith statws thyroid mamol wedi'i newid ar niwrodatblygiad. Rydym wedi defnyddio Banc Data SAIL i ddangos risg uwch o ddigwyddiadau cardiofasgwlaidd mewn cleifion ag Ymwrthedd i Hormonau Thyroid-Beta, gyda'r bwriad o archwilio therapïau newydd a allai liniaru'r risg hon.
Mae ein gwaith mewn anhwylderau steroid wedi dangos gwerth cortisol poer fel dewis arall i fesur serwm ar gyfer diagnosis annigonolrwydd adrenal. Rydym yn cymryd rhan mewn treialon clinigol mewn Hyperplasia Adrenal Congenital sydd wedi dod â chyffuriau newydd i'r farchnad, ac yn cydweithio ar astudiaethau aml-ganolfan (CAHASE2) i nodweddu canlyniadau clefyd yn yr anhwylder hwn.
Cyhoeddiad
2026
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- James, K. L. et al. 2026. EP125 - ECE_2541 - The views and experiences of adult women with congenital adrenal hyperplasia on childhood genital surgery: a qualitative study [Abstract]. European journal of endocrinology 195 (S1) 720. (10.1093/ejendo/lvag096.720)
- Forslund, M. et al., 2026. Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk. Journal of Internal Medicine (10.1111/joim.70156)
- Teede, H. J. et al., 2026. Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process. The Lancet 407 (10545), pp.2329-2339. (10.1016/s0140-6736(26)00717-8)
- Wright, M. E. , Rees, D. A. and Murphy, K. 2026. Advanced neuroimaging in PCOS: state-of-the-art techniques and emerging trends. Journal of Endocrinology 269 (2)(10.1530/JOE-25-0421)
- Wright, M. E. et al. 2026. Cerebrovascular function in women with polycystic ovary syndrome: a pilot multi-parameter magnetic resonance imaging study. Clinical Endocrinology 104 (5), pp.493-506. (10.1111/cen.70067)
- Bancos, I. et al., 2026. Adults with classic congenital adrenal hyperplasia taking crinecerfont demonstrated sustained decreases in glucocorticoid doses: 2-year results from the CAHtalyst Adult Study [Abstract]. Endocrine Practice 32 (4) S33. (10.1016/j.eprac.2026.01.095)
- Channon, S. et al. 2026. Research priorities for polycystic ovary syndrome. The Lancet Obstetrics, Gynaecology, & Women’s Health 2 (4), pp.e272-e274. (10.1016/s3050-5038(26)00018-x)
- Lawrence, N. et al., 2026. Adiposity rebound and height velocity in patients with congenital adrenal hyperplasia. European journal of endocrinology 194 (4), pp.467-481. lvag050. (10.1093/ejendo/lvag050)
- James, K. L. et al. 2026. Factors affecting the quality of life of adults living with Congenital Adrenal Hyperplasia: a qualitative study of lived experience. Endocrine Connections 15 (5) e260033. (10.1530/EC-26-0033)
- Richards, C. T. et al., 2026. Resting cerebrovascular haemodynamics and dynamic assessment of cerebrovascular function in polycystic ovary syndrome. Clinical Endocrinology 104 (3), pp.245-254. (10.1111/cen.70061)
- Rees, S. E. and Rees, D. A. 2026. Prolactinomas: Clinical manifestations and therapy. In: Huhtaniemi, I. ed. Encyclopedia of Endocrine Diseases (Third Edition). Vol. 2, Academic Press. , pp.404-413. (10.1016/B978-0-443-13825-6.00003-0)
- Roxas, A. et al., 2026. Glucocorticoid prescribing trends in congenital adrenal hyperplasia, 2017 to 2023. Endocrine Connections EC-25-0565. (10.1530/EC-25-0565)
- Prete, A. et al., 2026. Effects of modified release hydrocortisone on restoration of early morning cortisol, quality of life, and fatigue in adrenal insufficiency (The CHAMPAIN study): a randomised, double-blind, double-dummy, cross-over study comparing Chronocort and Plenadren. EClinicalMedicine 91 103714. (10.1016/j.eclinm.2025.103714)
- Rees, S. and Rees, D. A. 2026. Prolactinomas: Clinical manifestations and therapy. In: Huhtaniemi, I. ed. Encyclopedia of Endocrine Diseases, 3rd Edition. Academic Press. , pp.404-413. (10.1016/B978-0-443-13825-6.00003-0)
2025
- McNabb, C. B. et al. 2025. Controlled antenatal thyroid screening study III: effects of gestational thyroid status on brain microstructure. The Journal of Clinical Endocrinology & Metabolism 110 (12), pp.3322-3330. (10.1210/clinem/dgaf277)
- Ross, R. J. M. et al., 2025. Switching patients with congenital adrenal hyperplasia to modified‐release hydrocortisone capsules: Relative bioavailability and disease control. Clinical Endocrinology 103 (3), pp.290-293. (10.1111/cen.15275)
- Arlt, W. et al., 2025. Long-term outcomes in patients with congenital adrenal hyperplasia treated with hydrocortisone modified-release hard capsules. European journal of endocrinology 193 (1), pp.76-84. (10.1093/ejendo/lvaf130)
- Joham, A. E. et al., 2025. Epidemiological aspects of polycystic ovary syndrome. Reproduction REP-25-0121. (10.1530/rep-25-0121)
- Lawrence, N. R. et al., 2025. Modelling adrenal steroid profiles to inform monitoring guidance in congenital adrenal hyperplasia. EBioMedicine 116 105749. (10.1016/j.ebiom.2025.105749)
- Berni, T. R. , Morgan, C. L. and Rees, D. A. 2025. Rising incidence, health resource utilization, and costs of polycystic ovary syndrome in the United Kingdom. Journal of Clinical Endocrinology and Metabolism 110 (5), pp.e1580-e1589. (10.1210/clinem/dgae518)
- Domzaridou, E. et al., 2025. Treatment persistence and variations in prescribing oral, injectable, and inhaled corticosteroids: a population-based drug utilisation study. Pharmacoepidemiology & Drug Safety 34 (5) e70153. (10.1002/pds.70153)
- Adams, Z. et al., 2025. The impact of androgens on cardiovascular control mechanisms in polycystic ovary syndrome: Recent advances and translational approaches. The Journal of Physiology 603 (10), pp.2937-2957. (10.1113/JP287288)
- Wright, M. E. et al. 2025. Cortical vasculature in polycystic ovary syndrome and associations with circulating testosterone [Abstract]. Presented at: Society for Endocrinology BES 2025 Harrogate, UK 10-12 March 2025. BioScientifica. (10.1530/endoabs.109.P197)
2024
- Doyle, L. M. et al., 2024. Service evaluation suggests variation in clinical care provision in adults with congenital adrenal hyperplasia in the UK and Ireland. Clinical Endocrinology 101 (4), pp.386-396. (10.1111/cen.15043)
- Evans, C. et al., 2024. Current utility of first-line FT4 and TSH in screening for central hypothyroidism. Clinical Endocrinology 101 (1), pp.78-84. (10.1111/cen.15068)
- Rees, A. D. et al. 2024. Comparison of modified-release hydrocortisone capsules versus prednisolone in the treatment of congenital adrenal hyperplasia. Endocrine Connections 13 (8) e240150. (10.1530/EC-24-0150)
- Scholz, A. et al. 2024. Controlled antenatal thyroid screening study III: Effects of gestational thyroid status on adolescent brain morphology. The Journal of Clinical Endocrinology & Metabolism (10.1210/clinem/dgae338)
- Green, K. et al. 2024. Pearls and Oy-sters: AARS2 leukodystrophy – tremor and tribulations. Neurology 102 (8)(10.1212/WNL.0000000000209296)
- El-Farhan, N. et al., 2024. Salivary cortisol response to ACTH stimulation is a reliable alternative to serum cortisol in evaluating hypoadrenalism. The Journal of Clinical Endocrinology & Metabolism 109 (2), pp.e579-e588. dgad576. (10.1210/clinem/dgad576)
2023
- Papanikolaou, N. et al., 2023. Clinical characteristics of functioning gonadotroph adenoma in women presenting with ovarian hyperstimulation: audit of UK pituitary centres. Clinical Endocrinology 99 (4), pp.386-395. (10.1111/cen.14949)
- Schröder, M. et al., 2023. Hormonal control during infancy and testicular adrenal rest tumor development in males with congenital adrenal hyperplasia: A retrospective multicenter cohort study. European journal of endocrinology 189 (4), pp.460-468. (10.1093/ejendo/lvad143)
- Dong, J. and Rees, D. A. 2023. Polycystic Ovary Syndrome: Pathophysiology and therapeutic opportunities. BMJ Medicine 2 e000548. (10.1136/bmjmed-2023-000548)
- Berni, T. , Morgan, C. and Rees, D. 2023. SAT357 Rising incidence, health resource utilization and costs of polycystic ovary syndrome in the United Kingdom. Journal of the Endocrine Society 7 (S 1)(10.1210/jendso/bvad114.1662)
- Okosieme, O. et al. 2023. Cardiovascular morbidity and mortality in patients in Wales, UK with resistance to thyroid hormone β (RTHβ): a linked-record cohort study. The Lancet Diabetes & Endocrinology 11 (9), pp.657-666. (10.1016/S2213-8587(23)00155-9)
- Daughters, K. , Unwin, K. and Rees, D. A. 2023. The psychological impact of adult-onset craniopharyngioma: A qualitative study of the experience of patients and clinicians. European Journal of Oncology Nursing 65 102346. (10.1016/j.ejon.2023.102346)
- Elhassan, Y. S. et al., 2023. COVID-19-related Adrenal haemorrhage multicentre UK experience and systematic review of the literature. Clinical Endocrinology 98 (6), pp.766-778. (10.1111/cen.14881)
- Taylor, P. et al. 2023. Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice. Thyroid Research 16 7. (10.1186/s13044-023-00149-5)
- Tschaidse, L. et al., 2023. Modified-release hydrocortisone is associated with lower plasma renin activity in patients with salt-wasting congenital adrenal hyperplasia. European Journal of Endocrinology 188 (1) lvac006. (10.1093/ejendo/lvac006)
2022
- Daughters, K. , Rees, A. and Unwin, K. 2022. ODP365 The psychological impact of adult-onset craniopharyngioma: the experience of patients and clinicians. Journal of the Endocrine Society 6 (S1) A516. (10.1210/jendso/bvac150.1073)
- Perros, P. et al., 2022. Post-radioiodine Graves' management: the PRAGMA study. Clinical Endocrinology 97 (5), pp.664-675. (10.1111/cen.14719)
- Panagiotou, G. et al., 2022. Late offspring effects of antenatal thyroid screening. British Medical Bulletin 143 (1), pp.16-29. (10.1093/bmb/ldac018)
- Allen, L. , Shrikrishnapalasuriyar, N. and Rees, D. A. 2022. Long-term health outcomes in young women with Polycystic Ovary Syndrome: a narrative review. Clinical Endocrinology 97 (2), pp.187-198. (10.1111/cen.14609)
- Daughters, K. et al. 2022. Oxytocin administration versus emotion training in healthy males: Considerations for future research. Philosophical Transactions of the Royal Society B: Biological Sciences 377 (1858) 20210056. (10.1098/rstb.2021.0056)
- McCarthy, O. et al., 2022. Passing on the exercise baton: What can endocrine patients learn from elite athletes?. Clinical Endocrinology 96 (6), pp.781-792. (10.1111/cen.14683)
- Whelan, C. et al., 2022. The procoagulant effects of extracellular vesicles derived from hypoxic endothelial cells can be selectively inhibited by inorganic nitrite. Nitric Oxide: Biology and Chemistry 122-12 , pp.6-18. (10.1016/j.niox.2022.02.002)
- Cauldwell, M. et al., 2022. Pregnancies in women with Turner Syndrome: A retrospective multicentre UK study. BJOG: An International Journal of Obstetrics and Gynaecology 129 , pp.796-803. (10.1111/1471-0528.17025)
2021
- Draman, M. S. et al. 2021. Expression of endogenous putative TSH binding protein in orbit. Current Issues in Molecular Biology 43 (3), pp.1794-1804. (10.3390/cimb43030126)
- Zhang, L. et al. 2021. The role of mitochondria-linked fatty-acid uptake-driven adipogenesis in Graves’ Orbitopathy. Endocrinology 162 (12) bqab188. (10.1210/endocr/bqab188)
- Berni, T. R. , Morgan, C. L. and Rees, D. A. 2021. Women with Polycystic Ovary Syndrome have an increased risk of major cardiovascular events: a population study. Journal of Clinical Endocrinology and Metabolism 106 (9), pp.e3369-e3380. (10.1210/clinem/dgab392)
- Connolly, K. D. , Rees, D. A. and James, P. E. 2021. Role of adipocyte-derived extracellular vesicles in vascular inflammation. Free Radical Biology and Medicine 172 , pp.58-64. (10.1016/j.freeradbiomed.2021.04.031)
- Richards, C. T. et al., 2021. HIIT’ing or MISS’ing the optimal management of polycystic ovary syndrome: a systematic review and meta-analysis of high- versus moderate-intensity exercise prescription. Frontiers in Physiology 12 715881. (10.3389/fphys.2021.715881)
- Merke, D. P. et al., 2021. Modified-release hydrocortisone in congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism 106 (5), pp.e2063-e2077. (10.1210/clinem/dgab051)
- Thomas, M. et al., 2021. Insulin‐like growth factor‐1, growth hormone and disease outcomes in acromegaly: a population study. Clinical Endocrinology 95 (1), pp.143-152. (10.1111/cen.14468)
- Chambers, T. et al. 2021. Effects of thyroid status on regional brain volumes: a diagnostic and genetic imaging study in UK Biobank. Journal of Clinical Endocrinology and Metabolism 106 (3), pp.688-696. (10.1210/clinem/dgaa903)
- Lewis, R. D. et al. 2021. Complement activation in polycystic ovary syndrome occurs in the post-prandial and fasted state, and is influenced by obesity and insulin sensitivity. Clinical Endocrinology 94 (1), pp.74-84. (10.1111/cen.14322)
2020
- Zhang, L. et al. 2020. Distinctive features of orbital adipose tissue (OAT) in Graves' orbitopathy. International Journal of Molecular Sciences 21 (23) 9145. (10.3390/ijms21239145)
- Pak, H. Y. et al. 2020. Acromegaly and the information gap: patient perceptions of the journey from primary to tertiary care. Endocrine Connections 9 (10), pp.971-977. (10.1530/EC-20-0335)
- Galloway, L. et al., 2020. The impact of endoscopic transsphenoidal pituitary adenoma surgery on endocrine function: a single-centre study. Acta Neurochirurgica 163 (2), pp.391-398. (10.1007/s00701-020-04609-x)
- Muller, I. et al. 2020. CATS II long-term anthropometric and metabolic effects of maternal sub-optimal thyroid function in offspring and mothers. Journal of Clinical Endocrinology and Metabolism 105 (7) dgaa129. (10.1210/clinem/dgaa129)
- Ellins, E. et al., 2020. Associations of depression-anxiety and dyslipidaemia with subclinical carotid arterial disease: Findings from the Whitehall II Study. European Journal of Preventive Cardiology 27 (8), pp.800-807. (10.1177/2047487319876230)
- Napier, C. et al., 2020. Residual adrenal function in autoimmune addison's disease - effect of dual therapy with rituximab and depot tetracosactide. Journal of Clinical Endocrinology and Metabolism 105 (4) Volume 105, Issue 4, April 2020,. (10.1210/clinem/dgz287)
- Hayhurst, C. et al., 2020. Current perspectives on recurrent pituitary adenoma: the role and timing of surgery vs adjuvant treatment. Clinical Endocrinology 92 (2), pp.89-97. (10.1111/cen.14127)
2019
- Lansdown, A. et al. 2019. Regional cerebral activation accompanies sympathoexcitation in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 104 (9), pp.3614-3623. (10.1210/jc.2019-00065)
- Wilson, N. et al., 2019. Role of hyaluronan in human adipogenesis: Evidence from in-vitro and in-vivo studies. International Journal of Molecular Sciences 20 (11) 2675. (10.3390/ijms20112675)
- Wadey, R. M. et al., 2019. Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells. Atherosclerosis 283 , pp.19-27. (10.1016/j.atherosclerosis.2019.01.013)
- Bhargava, R. , Daughters, K. L. and Rees, D. A. 2019. Oxytocin therapy in hypopituitarism: challenges and opportunities. Clinical Endocrinology 90 (2), pp.257-264. (10.1111/cen.13909)
2018
- Scholz, A. and Rees, D. A. 2018. Prolactinomas: Clinical manifestations and therapy. In: Huhtaniemi, I. and Martini, L. eds. Encyclopedia of Endocrine Diseases (Second Edition). Elsevier. , pp.319-324. (10.1016/B978-0-12-801238-3.65181-4)
- Trainer, P. J. et al., 2018. A randomised, open-label, parallel group phase 2 study of antisense oligonucleotide therapy in acromegaly. European Journal of Endocrinology 179 (2), pp.97-108. (10.1530/EJE-18-0138)
- Berni, T. et al. 2018. Polycystic ovary syndrome is associated with adverse mental health and neurodevelopmental outcomes. Journal of Clinical Endocrinology and Metabolism 103 (6), pp.2116-2125. (10.1530/endoabs.50.P353)
- Hales, C. et al. 2018. Controlled antenatal thyroid screening II: effect of treating maternal sub-optimal thyroid function on child cognition. Journal of Clinical Endocrinology and Metabolism 103 (4), pp.1583-1591. (10.1210/jc.2017-02378)
- Rees, D. A. 2018. Tips from the shop floor: Addisonian crisis - assessment and management. British Journal of Hospital Medicine 79 (3), pp.34-37. (10.12968/hmed.2018.79.3.C34)
- Witczak, J. K. et al. 2018. Bariatric surgery is accompanied by changes in extracellular vesicle-associated and plasma fatty acid binding protein 4. Obesity Surgery 28 (3), pp.767-774. (10.1007/s11695-017-2879-z)
- Burnley-Hall, N. et al. 2018. Dietary nitrate supplementation reduces circulating platelet-derived extracellular vesicles in coronary artery disease patients on clopidogrel therapy: a randomised, double-blind, placebo-controlled study. Thrombosis and Haemostasis 118 (01), pp.112-122. (10.1160/TH17-06-0394)
- Connolly, K. D. et al. 2018. Evidence for adipocyte-derived extracellular vesicles in the human circulation. Endocrinology 159 (9), pp.3259-3267. (10.1210/en.2018-00266)
2017
- Hubble, K. et al. 2017. Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear. Neuropsychologia 106 , pp.350-357. (10.1016/j.neuropsychologia.2017.10.019)
- Daughters, K. , Manstead, A. S. R. and Rees, D. A. 2017. Hypopituitarism is associated with lower oxytocin concentrations and reduced empathic ability. Endocrine 57 (1), pp.166-174. (10.1007/s12020-017-1332-3)
- Taylor, P. et al. 2017. Cerebral salt wasting following traumatic brain injury. Endocrinology, Diabetes & Metabolism Case Reports (10.1530/EDM-16-0142)
- Taylor, P. N. et al. 2017. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study. Journal of Clinical Endocrinology and Metabolism 102 (7), pp.2508-2515. (10.1210/jc.2016-3605)
- Arlt, W. et al., 2017. Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism. JCI Insight 2 (8) e93136. (10.1172/jci.insight.93136)
- El-Farhan, N. , Rees, D. A. and Evans, C. 2017. ANNALS EXPRESS: Measuring cortisol in serum, urine and saliva – are our assays good enough?. Annals of Clinical Biochemistry 54 (3), pp.308-322. (10.1177/0004563216687335)
- Draman, M. S. et al. 2017. The role of thyrotropin receptor activation in adipogenesis and modulation of fat phenotype. Frontiers in Endocrinology 8 83. (10.3389/fendo.2017.00083)
- Burnley-Hall, N. et al. 2017. Nitrite-derived nitric oxide reduces hypoxia-inducible factor 1α-mediated extracellular vesicle production by endothelial cells. Nitric Oxide: Biology and Chemistry 63 , pp.1-12. (10.1016/j.niox.2016.12.005)
- Ellins, E. A. et al. 2017. Increased fibrinogen responses to psychophysiological stress predict future endothelial dysfunction implications for cardiovascular disease?. Brain, Behavior, and Immunity 60 , pp.233-239. (10.1016/j.bbi.2016.10.017)
2016
- Hubble, K. et al. 2016. Oxytocin reduces face processing time but leaves recognition accuracy and eye-gaze unaffected. Journal of the International Neuropsychological Society 23 (1), pp.23-33. (10.1017/S1355617716000886)
- Drake, W. M. et al., 2016. A follow-up study of the prevalence of valvular heart abnormalities in hyperprolactinemic patients treated with cabergoline. Journal of Clinical Endocrinology & Metabolism 101 (11), pp.4189-4194. (10.1210/jc.2016-2224)
- Bondugulapati, L. and Rees, D. A. 2016. Inhaled corticosteroids and HPA axis suppression: how important is it and how should it be managed?. Clinical Endocrinology 85 (2), pp.165-169. (10.1111/cen.13073)
- Rees, D. A. , Jenkins-Jones, S. and Morgan, C. L. 2016. Contemporary reproductive outcomes for patients with polycystic ovary syndrome: a retrospective observational study. Journal of Clinical Endocrinology & Metabolism 101 (4), pp.1664-1672. (10.1210/jc.2015-2682)
- Roy Chowdhury, S. et al. 2016. Diabetic retinopathy in newly diagnosed subjects with type 2 diabetes mellitus: contribution of β-Cell function. Journal of Clinical Endocrinology and Metabolism 101 (2), pp.572-580. (10.1210/jc.2015-2203)
- Taylor, P. et al. 2016. Paradoxical relationship between body mass index and thyroid hormone levels: a study using Mendelian randomization. Journal of Clinical Endocrinology & Metabolism 101 (2), pp.730-738. (10.1210/jc.2015-3505)
- Rees, D. A. et al. 2016. White matter microstructure and cognitive function in young women with polycystic ovary syndrome. Journal of Clinical Endocrinology & Metabolism 101 (1), pp.314-323. (10.1210/jc.2015-2318)
2015
- Daughters, K. et al. 2015. Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study. PLoS ONE 10 (12) e0145104. (10.1371/journal.pone.0145104)
- Connolly, K. D. et al., 2015. Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis. Journal of Extracellular Vesicles 4 (s1) 29159. (10.3402/jev.v4.29159)
- Grant, P. et al., 2015. Response to 'How we define hyponatremia'?. European Journal of Clinical Investigation 45 (11), pp.1218. (10.1111/eci.12515)
- Daniel, E. et al., 2015. Effectiveness of metyrapone in treating Cushing's Syndrome: a retrospective multicenter study in 195 patients. Journal of Clinical Endocrinology & Metabolism 100 (11), pp.4146. (10.1210/jc.2015-2616)
- Bondugulapati, L. N. R. et al. 2015. Use of day 1 early morning cortisol to predict the need for glucocorticoid replacement after pituitary surgery. British Journal of Neurosurgery 30 (1), pp.76-79. (10.3109/02688697.2015.1071325)
- Ellins, E. A. et al. 2015. Validation of a new method for non-invasive assessment of vasomotor function. European Journal of Preventive Cardiology 23 (6), pp.577-583. (10.1177/2047487315597210)
- Margulescu, A. D. et al., 2015. Do left atrial strain and strain rate reflect intrinsic atrial function, or are they determined by left ventricular function?. Kardiologia Polska 73 (7), pp.539-548. (10.5603/KP.a2015.0035)
- Grant, P. et al., 2015. The diagnosis and management of inpatient hyponatraemia and SIADH. European Journal of Clinical Investigation 45 (8), pp.888-894. (10.1111/eci.12465)
- Dénes, J. et al., 2015. Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a large patient cohort. Journal of Clinical Endocrinology & Metabolism 100 (3), pp.E531. (10.1210/jc.2014-3399)
2014
- Willis, G. R. et al. 2014. Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles. Human Reproduction 29 (12), pp.2756-2763. (10.1093/humrep/deu281)
- Willis, G. R. et al., 2014. Detailed characterisation of circulatory nitric oxide and free radical indices-is there evidence for abnormal cardiovascular homeostasis in young women with polycystic ovary syndrome?. BJOG: An International Journal of Obstetrics and Gynaecology 121 (13), pp.1596-1603. (10.1111/1471-0528.12834)
- Connolly, K. D. et al. 2014. Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia. Journal of Lipid Research 55 , pp.2064-2072. (10.1194/jlr.M049726)
- Muller, I. and Rees, D. A. 2014. Melasma and endocrine disorders. Journal of Pigmentary Disorders S1 001. (10.4172/2376-0427.1000S1001)
- Gagliardi, L. et al., 2014. ARMC5 mutations are common in familial bilateral macronodular adrenal hyperplasia. Journal of Clinical Endocrinology & Metabolism 99 (9) E1784. (10.1210/jc.2014-1265)
- Rees, E. et al., 2014. Central arterial stiffness and diastolic dysfunction are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk. Human Reproduction 29 (9), pp.2041-2049. (10.1093/humrep/deu180)
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- Connolly, K. D. et al. 2018. Evidence for adipocyte-derived extracellular vesicles in the human circulation. Endocrinology 159 (9), pp.3259-3267. (10.1210/en.2018-00266)
- Hubble, K. et al. 2017. Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear. Neuropsychologia 106 , pp.350-357. (10.1016/j.neuropsychologia.2017.10.019)
- Daughters, K. , Manstead, A. S. R. and Rees, D. A. 2017. Hypopituitarism is associated with lower oxytocin concentrations and reduced empathic ability. Endocrine 57 (1), pp.166-174. (10.1007/s12020-017-1332-3)
- Taylor, P. et al. 2017. Cerebral salt wasting following traumatic brain injury. Endocrinology, Diabetes & Metabolism Case Reports (10.1530/EDM-16-0142)
- Taylor, P. N. et al. 2017. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study. Journal of Clinical Endocrinology and Metabolism 102 (7), pp.2508-2515. (10.1210/jc.2016-3605)
- Arlt, W. et al., 2017. Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism. JCI Insight 2 (8) e93136. (10.1172/jci.insight.93136)
- El-Farhan, N. , Rees, D. A. and Evans, C. 2017. ANNALS EXPRESS: Measuring cortisol in serum, urine and saliva – are our assays good enough?. Annals of Clinical Biochemistry 54 (3), pp.308-322. (10.1177/0004563216687335)
- Draman, M. S. et al. 2017. The role of thyrotropin receptor activation in adipogenesis and modulation of fat phenotype. Frontiers in Endocrinology 8 83. (10.3389/fendo.2017.00083)
- Burnley-Hall, N. et al. 2017. Nitrite-derived nitric oxide reduces hypoxia-inducible factor 1α-mediated extracellular vesicle production by endothelial cells. Nitric Oxide: Biology and Chemistry 63 , pp.1-12. (10.1016/j.niox.2016.12.005)
- Ellins, E. A. et al. 2017. Increased fibrinogen responses to psychophysiological stress predict future endothelial dysfunction implications for cardiovascular disease?. Brain, Behavior, and Immunity 60 , pp.233-239. (10.1016/j.bbi.2016.10.017)
- Hubble, K. et al. 2016. Oxytocin reduces face processing time but leaves recognition accuracy and eye-gaze unaffected. Journal of the International Neuropsychological Society 23 (1), pp.23-33. (10.1017/S1355617716000886)
- Drake, W. M. et al., 2016. A follow-up study of the prevalence of valvular heart abnormalities in hyperprolactinemic patients treated with cabergoline. Journal of Clinical Endocrinology & Metabolism 101 (11), pp.4189-4194. (10.1210/jc.2016-2224)
- Bondugulapati, L. and Rees, D. A. 2016. Inhaled corticosteroids and HPA axis suppression: how important is it and how should it be managed?. Clinical Endocrinology 85 (2), pp.165-169. (10.1111/cen.13073)
- Rees, D. A. , Jenkins-Jones, S. and Morgan, C. L. 2016. Contemporary reproductive outcomes for patients with polycystic ovary syndrome: a retrospective observational study. Journal of Clinical Endocrinology & Metabolism 101 (4), pp.1664-1672. (10.1210/jc.2015-2682)
- Roy Chowdhury, S. et al. 2016. Diabetic retinopathy in newly diagnosed subjects with type 2 diabetes mellitus: contribution of β-Cell function. Journal of Clinical Endocrinology and Metabolism 101 (2), pp.572-580. (10.1210/jc.2015-2203)
- Taylor, P. et al. 2016. Paradoxical relationship between body mass index and thyroid hormone levels: a study using Mendelian randomization. Journal of Clinical Endocrinology & Metabolism 101 (2), pp.730-738. (10.1210/jc.2015-3505)
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- Grant, P. et al., 2015. The diagnosis and management of inpatient hyponatraemia and SIADH. European Journal of Clinical Investigation 45 (8), pp.888-894. (10.1111/eci.12465)
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- Willis, G. R. et al. 2014. Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles. Human Reproduction 29 (12), pp.2756-2763. (10.1093/humrep/deu281)
- Willis, G. R. et al., 2014. Detailed characterisation of circulatory nitric oxide and free radical indices-is there evidence for abnormal cardiovascular homeostasis in young women with polycystic ovary syndrome?. BJOG: An International Journal of Obstetrics and Gynaecology 121 (13), pp.1596-1603. (10.1111/1471-0528.12834)
- Connolly, K. D. et al. 2014. Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia. Journal of Lipid Research 55 , pp.2064-2072. (10.1194/jlr.M049726)
- Muller, I. and Rees, D. A. 2014. Melasma and endocrine disorders. Journal of Pigmentary Disorders S1 001. (10.4172/2376-0427.1000S1001)
- Gagliardi, L. et al., 2014. ARMC5 mutations are common in familial bilateral macronodular adrenal hyperplasia. Journal of Clinical Endocrinology & Metabolism 99 (9) E1784. (10.1210/jc.2014-1265)
- Rees, E. et al., 2014. Central arterial stiffness and diastolic dysfunction are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk. Human Reproduction 29 (9), pp.2041-2049. (10.1093/humrep/deu180)
- Han, T. S. et al., 2014. Relationship between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE). Journal of Clinical Endocrinology & Metabolism 99 (8), pp.E1547-E1555. (10.1210/jc.2014-1486)
- Evans, C. et al., 2014. Response to 'Determining the utility of the 60-min cortisol measurement in the short Synacthen test'. Clinical Endocrinology 80 (5), pp.766-767. (10.1111/cen.12272)
- Ibrahim, R. et al., 2014. Dense calcification in a GH-secreting pituitary macroadenoma. Endocrinology, Diabetes & Metabolism Case Reports EDM130079. (10.1530/EDM-13-0079)
- Dodd, A. et al., 2014. The effect of serum matrix and gender on cortisol measurement by commonly used immunoassays. Annals of Clinical Biochemistry 51 (3), pp.379-385. (10.1177/0004563213514567)
- Hales, C. et al. 2014. The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol. BMC Endocrine Disorders 14 (1) 95. (10.1186/1472-6823-14-95)
- Owen, L. J. et al., 2013. Development of a rapid assay for the analysis of serum cortisol and its implementation into a routine service laboratory. Annals of Clinical Biochemistry 50 (4), pp.345-352. (10.1177/0004563212473448)
- Han, T. S. et al., 2013. Quality of life in adults with congenital adrenal hyperplasia relates to glucocorticoid treatment, adiposity and insulin resistance: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE). European Journal of Endocrinology 168 (6), pp.887-893. (10.1530/EJE-13-0128)
- Han, T. S. et al., 2013. Glucocorticoid treatment regimen and health outcomes in adults with congenital adrenal hyperplasia. Clinical Endocrinology 78 (2), pp.197-203. (10.1111/cen.12045)
- Al-Sarireh, B. et al., 2013. Glucagon cell adenomatosis without glucagon receptor mutation [letter]. Pancreas 42 (2), pp.360-362. (10.1097/MPA.0b013e31825b6acd)
- Das, G. et al., 2013. Late presentation of hyperandrogenism in pregnancy: clinical features and differential diagnosis. Endocrinology, Diabetes & Metabolism Case Reports 10 EDM130048. (10.1530/EDM-13-0048)
- El-Farhan, N. et al. 2013. Method-specific serum cortisol responses to the adrenocorticotrophin test: comparison of gas chromatography-mass spectrometry and five automated immunoassays. Clinical Endocrinology 78 (5), pp.673-680. (10.1111/cen.12039)
- Neale, S. M. et al., 2013. Adult testosterone and calculated free testosterone reference ranges by tandem mass spectrometry. Annals of Clinical Biochemistry 50 (2), pp.159-161. (10.1258/acb.2012.012047)
- Morgan, C. L. et al. 2012. Evaluation of adverse outcome in young women with polycystic ovary syndrome versus matched, reference controls: a retrospective, observational study. Journal of Clinical Endocrinology & Metabolism 97 (9), pp.3251-3260. (10.1210/jc.2012-1690)
- Zhang, L. et al. 2012. Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy. Journal of Clinical Endocrinology & Metabolism 97 (2), pp.653-662. (10.1210/jc.2011-1299)
- Biswas, M. et al., 2012. Total and free testosterone concentrations are strongly influenced by age and central obesity in men with type 1 and type 2 diabetes but correlate weakly with symptoms of androgen deficiency and diabetes-related quality of life. Clinical Endocrinology 76 (5), pp.665-673. (10.1111/j.1365-2265.2011.04196.x)
- Kalhan, A. et al. 2012. Adenosine A2A and A2B receptor expression in neuroendocrine tumours: potential targets for therapy. Purinergic Signalling 8 (2), pp.265-274. (10.1007/s11302-011-9280-5)
- Lansdown, A. and Rees, D. A. 2012. The sympathetic nervous system in polycystic ovary syndrome: a novel therapeutic target?. Clinical Endocrinology 77 (6), pp.791-801. (10.1111/cen.12003)
- Lansdown, A. J. , Ludgate, M. E. and Rees, D. A. 2012. Metabolic syndrome: is the preadipocyte to blame? [Commentary]. Clinical Endocrinology 76 (1), pp.19-20. (10.1111/j.1365-2265.2011.04176.x)
- Lunenfeld, B. et al., 2012. How to help the aging male? Current approaches to hypogonadism in primary care. The Aging Male 15 (4), pp.187-197. (10.3109/13685538.2012.729110)
- Lansdown, A. J. and Rees, D. A. 2011. Endocrine oncology in pregnancy. Best Practice & Research Clinical Endocrinology & Metabolism 25 (6), pp.911-926. (10.1016/j.beem.2011.06.011)
- Stephens, M. W. , Ludgate, M. E. and Rees, D. A. 2011. Brown fat and obesity: the next big thing?. Clinical Endocrinology 74 (6), pp.661-670. (10.1111/j.1365-2265.2011.04018.x)
- Wiebke, A. et al., 2010. Health status of adults with congenital adrenal hyperplasia: A cohort study of 203 patients. Journal of Clinical Endocrinology & Metabolism 95 (11), pp.5110-5121. (10.1210/jc.2010-0917)
- Biswas, M. et al. 2010. Reduced total testosterone concentrations in young healthy South Asian men are partly explained by increased insulin resistance but not by altered adiposity. Clinical Endocrinology 73 (4), pp.457-462. (10.1111/j.1365-2265.2010.03824.x)
- Rice, S. P. L. et al. 2010. Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue. Molecular and Cellular Endocrinology 320 (1-2), pp.51-57. (10.1016/j.mce.2010.02.017)
- Agarwal, N. et al. 2010. Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: A randomized, placebo-controlled, crossover trial. Obstetrical & Gynecological Survey 65 (6), pp.381-382. (10.1097/OGX.0b013e3181e5a167)
- Agarwal, N. et al. 2010. Metformin Reduces Arterial Stiffness and Improves Endothelial Function in Young Women with Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled, Crossover Trial. Journal of Clinical Endocrinology & Metabolism 95 (2), pp.722-730. (10.1210/jc.2009-1985)
- De Lloyd, A. C. et al. 2010. TSH receptor activation and body composition. Journal of Endocrinology 204 (1), pp.13-20. (10.1677/JOE-09-0262)
- Rees, D. A. and Dayan, C. M. 2010. Commentary: Testosterone and the metabolic syndrome: cause or consequence?. International Journal of Epidemiology 40 (1), pp.207-209. (10.1093/ije/dyq254)
- Rice, S. P. L. et al. 2009. Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: A randomized crossover trial. Journal of Clinical Endocrinology & Metabolism 94 (6), pp.1966-1972. (10.1210/jc.2008-2636)
- Colao, A. et al., 2009. Octreotide LARvs.surgery in newly diagnosed patients with acromegaly: a randomized, open-label, multicentre study. Clinical Endocrinology 70 (5), pp.757-768. (10.1111/j.1365-2265.2008.03441.x)
- Krone, N. et al., 2009. Current management, morbidity and genotypephenotype correlation in adults with congenital adrenal hyperplasia – analysis of the United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE) cohort [Abstract]. Hormone Research 72 (S3), pp.41-41. (10.1159/000239668)
- Rees, D. A. et al. 2009. Adenosine regulates thrombomodulin and endothelial protein C receptor expression in folliculostellate cells of the pituitary gland. Purinergic Signalling 6 (1), pp.19-29. (10.1007/s11302-009-9172-0)
- Watson, S. et al., 2009. Can abdominal bioelectrical impedance refine the determination of visceral fat from waist circumference?. Physiological Measurement 30 (7), pp.N53-N58. (10.1088/0967-3334/30/7/N01)
- Ham, J. and Rees, D. A. 2008. The adenosine a2b receptor: its role in inflammation. Endocrine‚ Metabolic & Immune Disorders - Drug Targets 8 (4), pp.244-254.
- Millar, D. S. et al. 2008. Growth hormone (GH1) gene variation and the growth hormone receptor (GHR) exon 3 deletion polymorphism in a West-African population. Molecular and Cellular Endocrinology 296 (1-2), pp.18-25. (10.1016/j.mce.2008.09.023)
- Cozma, I. et al., 2007. Modulation of expression of somatostatin receptor subtypes in Graves' opthalmopathy orbits : relevance to novel analogues. American Journal of Physiology. Endocrinology and Metabolism (10.1152/ajpendo.00177.2007)
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Llyfrau
- Scanlon, M. and Rees, D. A. eds. 2008. Specialist training in endocrinology. Edinburgh: Mosby/Elsevier.
Ymchwil
Prosiectau cyfredol
Mae fy astudiaethau cyfredol yn defnyddio MRI uwch i ddeall effaith yr amgylchedd hormonaidd mewn bywyd cynnar ar wybyddiaeth a niwrodatblygiad. Mae fy ngrŵp wedi dangos microstrwythur mater gwyn a gallu gwybyddol wedi'i newid mewn menywod ifanc â Syndrom Ofari Metabolig Polyendocrin (PMOS), gan adeiladu ar astudiaethau epidemiolegol a gwyddoniaeth sylfaenol blaenorol sydd wedi sefydlu'r canlyniadau metabolig a cardiofasgwlaidd hirdymor yn y boblogaeth gleifion hon. Bydd ein hastudiaeth ddilynol hirdymor o blant a anwyd i famau yn y treial Sgrinio Thyroid Cynenedigol a Reolir (CATS) yn ein galluogi i asesu effeithiau dod i gysylltiad â hormonau thyroid yn ystod beichiogrwydd ar niwrodatblygiad, gan ddefnyddio'r cyfleusterau MRI o'r radd flaenaf yng Nghanolfan Delweddu Ymchwil yr Ymennydd Prifysgol Caerdydd (CUBRIC).
Mae dadansoddiadau epidemiolegol a genetig mewn setiau data mawr, gan gynnwys CPRD a UK Biobank, yn archwilio morbidrwydd cardiofasgwlaidd mewn menywod â PMOS, ac effeithiau statws thyroid mamol ar strwythur yr ymennydd a chanlyniadau addysgol. Mae astudiaethau mewn Resistance to Thyroid Hormone Beta yn cynnwys astudiaeth banc data a fydd yn amlinellu canlyniadau iechyd hirdymor a threialon clinigol o therapïau newydd.
Mae Partneriaeth Gosod Blaenoriaethau Cynghrair James Lind yn PMOS wedi sefydlu'r 10 blaenoriaeth ymchwil uchaf ar gyfer yr anhwylder hwn.
Cyllid
2024-2026 "Partneriaeth Gosod Blaenoriaethau i nodi'r 10 prif flaenoriaeth ymchwil ar gyfer pobl sy'n byw gyda Syndrom Ofari Polycystig a'r ymarferwyr sy'n darparu eu gofal iechyd"; Math: Grant prosiect; Prif Ymchwilydd: Rees DA; Cyd-ymchwilwyr: Channon S, Morman R, Andrews C. Asiantaeth: Sefydliad Waterloo; Cyllideb: £64,160
2021-2022 "Pa gleifion sy'n cymryd therapi glucocorticoid sydd mewn perygl o argyfwng adrenal a chanlyniadau niweidiol mawr yn yr ysbyty? Defnyddio cofnodion iechyd electronig y byd go iawn i lywio dull addysgol haenog risg."; Math: Cymrodoriaeth Ymchwil Glinigol; Cymrawd Ymchwil: Williams D; Goruchwylydd: Rees DA; Asiantaeth: Coleg Brenhinol y Meddygon; Cyllideb: £30,000
2021-2022 "Datrysiadau Diogelwch Steroidau: Datblygu ac Effaith Gwasanaeth Cyngor Steroidau Fferylliaeth ar Ddiogelwch Cleifion ac Ymarfer Proffesiynol"; Math: Grant prosiect; Prif Ymchwilydd: James L; Cyd-ymchwilwyr: Rees DA, James D; Asiantaeth: Llywodraeth Cynulliad Cymru (Fferylliaeth: darparu Cymru Iachach); Cyllideb: £18,477
2021-2022 "Penderfynu ar rôl estrogen mewn iechyd fasgwlaidd ac amddiffyn ar draws hyd oes"; Math: Grant prosiect; Cymrawd Ymchwil: Steventon J; Goruchwylwyr: Rees DA, Murphy K; Asiantaeth: Cronfa Ymchwil Cardiofasgwlaidd Syr Geraint Evans; Cyllideb: £45,298.
2019-2021 "Rôl estrogen mewn heneiddio fasgwlaidd"; Math: Cymrodoriaeth ISSF; Cymrawd Ymchwil: Steventon J; Goruchwylwyr: Rees DA, Murphy K; Asiantaeth: Ymddiriedolaeth Wellcome; Cyllideb: £84,678.
2019-2021 "Effeithiau hyfforddiant egwyl dwysedd uchel yn erbyn hyfforddiant cyflwr sefydlog dwysedd cymedrol ar iechyd meddwl, canlyniadau gwybyddol a cardiometabolig mewn menywod ifanc â Syndrom Ofari Polycystig: treial peilot ar hap, a reolir"; Math: Grant Prosiect; Prif Ymchwilydd: Rees DA; Asiantaeth: Sefydliad Waterloo; Cyllideb: £73,209.
2018-2020 "Effeithiau amlygiad hormonau thyroid beichiogrwydd ar risg ADHD: mewnwelediadau i niwroddatblygiad gan ddefnyddio MRI uwch"; Math: Cymrodoriaeth Ymchwil Glinigol (i Scholz); Prif Ymchwilydd: Rees DA; Asiantaeth: Coleg Brenhinol y Meddygon (Lewis Thomas Gibbon Jenkins o Gymrodoriaeth Llansawel Ferry); Cyllideb: £30,000
2018-2020 "Trin swyddogaeth thyroid mamol is-optimaidd fel ffenestr i fecanweithiau datblygiad a swyddogaeth yr ymennydd plentyndod"; Math: Grant Prosiect; Prif Ymchwilydd: Rees DA; Asiantaeth: Sefydliad Waterloo; Cyllideb: £59,531
2015-2017 "Microronynnau sy'n deillio o gelloedd fel cyfryngwyr clefyd fasgwlaidd sy'n ysgogi gordewdra"; Math: Cymrodoriaeth Ymchwil Glinigol (i Witczak); Prif Ymchwilydd: Rees DA; Cyd-ymchwilwyr: James PJ, Witczak J; Asiantaeth: Coleg Brenhinol y Meddygon; Cyllideb: £120,417
2015-2018 "Cludiant fesigl allgellog yn y cylchrediad - cyswllt coll rhwng adipocytes a chamweithrediad fasgwlaidd cyflym"; Math: Grant Prosiect; Prif Ymchwilydd: James PJ; Cyd-ymchwilwyr: Rees DA, Ludgate M, Lewis T, Clayton A, O'Donnell V. Asiantaeth: Sefydliad Prydeinig y Galon; Cyllideb: £226,891
2014-2017 "Mesur poblogaethau microvesicle sy'n berthnasol yn patholegol mewn clefyd cardiofasgwlaidd sy'n cael ei yrru gan ordewdra"; Math: Ysgoloriaeth PhD; Prif Ymchwilydd:James PJ; Cyd-Ymchwilydd: Rees DA; Asiantaeth: Coleg Biofeddygol a Gwyddorau Bywyd Prifysgol Caerdydd; Cyllideb: £75,000
2014-2017"A allwn ni atal cynhyrchu poblogaethau fesigl allgellog pro-thrombotig a pro-geulo mewn gwaed trwy ymyrraeth dietegol syml?" Math: Ysgoloriaeth PhD; Prif Ymchwilydd: Rees DA; Cyd-ymchwilydd: James PJ; Asiantaeth: Sefydliad Cenedlaethol Gofal Cymdeithasol ac Ymchwil Iechyd; Cyllideb: £66,926
2014-2015"Ystadegydd Rhwydwaith Ymchwil Diabetes" Math: Grant. Prif Ymchwilydd: Rees DA; Cyd-ymchwilydd: Dayan C; Asiantaeth: Sefydliad Cenedlaethol Gofal Cymdeithasol ac Ymchwil Iechyd; Cyllideb: £53,344
2012-2015 "Y rhyngwyneb rhwng microvesicles sy'n deillio o feinwe adipose ac endotheliwm fasgwlaidd mewn syndrom ofari polycystig"; Math: Ysgoloriaeth PhD; Prif Ymchwilydd: Rees DA; Cyd-ymchwilydd: James PJ; Asiantaeth: Ysgoloriaeth Cymynrodd Ewen Maclean Prifysgol Caerdydd; Cyllideb: £66,402
2012-2013 "Cydberthynas anthropometrig a metabolig gweithgaredd system nerfol sympathetig mewn menywod ifanc â PCOS: astudiaeth MRI swyddogaethol"; Math: Gwobr Gyrfa Gynnar; Prif Ymchwilydd: Rees DA; Cyd-ymchwilydd: Lansdown A; Asiantaeth: Cymdeithas Endocrinoleg; Cyllideb: £10,000
2012-2013 "Astudiaeth beilot i benderfynu a yw actifadu cyflenwad yn modiwleiddio metaboledd lipid mewn iechyd a chlefydau" Math: Cymrodoriaeth ISSF Ymddiriedolaeth Wellcome; Prif Ymchwilydd: Lewis R; Cyd-ymchwilwyr: Rees DA, Morgan BP; Asiantaeth: Wellcome Trust; Cyllideb: £44,130
2011-2014 "Dylanwad adiposity rhanbarthol ar effeithiau endothelial colesterol LDL mewn Syndrom Ofari Polycystig"; Math: ysgoloriaeth PhD; Prif Ymchwilydd: James PJ; Cyd-Ymchwilydd: Rees DA; Asiantaeth: Ysgoloriaeth Cymynrodd John Nixon Prifysgol Caerdydd; Cyllideb: £68,412
Effaith
Rwyf wedi sefydlu carfan fawr o gleifion ifanc â Syndrom Ofari Polycystig (PCOS), gan ddefnyddio hyn fel model clinigol cyffredin (5-10% menywod cyn y menopos) o ordewdra metabolig afiach a risg fasgwlaidd bywyd cynnar.
Defnyddiais gyfres o fethodolegau cardiofasgwlaidd anfewnwthiol i ffenoteipio'r garfan yn ofalus a dangos pwysigrwydd ymwrthedd i inswlin a gordewdra canolog fel marcwyr risg cardiofasgwlaidd annibynnol. Ymgymerodd fy ngrŵp â threial ar hap, dwbl dall, a reolir gan placebo i ddangos bod metformin yn gwella swyddogaeth fasgwlaidd mewn menywod â PCOS. Rwyf hefyd wedi manteisio ar bŵer y Gronfa Ddata Ymchwil Ymarfer Clinigol i ddiffinio hanes naturiol PCOS, gan gadarnhau risg uwch o ddiabetes math 2, canlyniadau beichiogrwydd niweidiol, canlyniadau iechyd meddwl niweidiol a digwyddiadau cardiofasgwlaidd, yn ogystal ag effaith sylweddol ar economi gofal iechyd y DU.
Mae gen i ddiddordeb cryf hefyd mewn anhwylderau steroid; mewn clefyd adrenal, arweiniais ddau dreial clinigol a ail-ddiffiniodd derfynau cyfeirio method-benodol i'r prawf synacthen, dangosodd ddilysrwydd ymatebion poer, ac archwilio effeithiau DHEA ar swyddogaeth fasgwlaidd. Rwyf wedi cynnal nifer o astudiaethau mewn Hyperplasia Adrenal Congenital sydd wedi helpu i ddiffinio'r canlyniadau iechyd a chyfrannu at ddatblygu therapïau newydd.
Mae dilyniant y garfan astudiaeth Sgrinio Thyroid Cynenedigol a Reolir (CATS) wedi egluro pwysigrwydd osgoi gor-ddisodli â levothyroxine yn ystod beichiogrwydd, tra hefyd yn dangos effaith ar ficrostrwythur ymennydd y glasoed.
Rwy'n lledaenu fy ngwaith yn rheolaidd drwy ymgysylltu â grwpiau cleifion, y Gymdeithas Endocrinoleg a'r cyfryngau (BBC, S4C, Radio Cymru).
Addysgu
Rwy'n cyfrannu at gyflwyno, dylunio ac asesu'r cwricwlwm meddygol israddedig o flynyddoedd 1 hyd at 5, ac yn chwarae rhan weithredol mewn addysgu meddygol ôl-raddedig ar lefelau lleol a chenedlaethol.
Is-raddedig
Rwy'n darparu addysgu cleifion allanol a ward i fyfyrwyr blwyddyn 3-5, ac yn goruchwylio prosiectau cydrannau a ddewiswyd gan fyfyrwyr ym mlynyddoedd 3 a 4. Ar ôl cyflwyno'r cwricwlwm israddedig C21 yng Nghaerdydd, cwblheais y Rhaglen Cyfeiriadedd Addysg Feddygol (MEOP), daeth yn diwtor ar 'hormonau atgenhedlu' ar gyfer y Llwyfan mewn Gwyddoniaeth Glinigol yng ngham 1a (blwyddyn 1) ac arweinydd ysgrifennu ar sail achos ('Diabetes mewn person hŷn') ar gyfer cam 1b (blwyddyn 2). Rwy'n fentor academaidd ar gyfer israddedigion meddygol ac wedi bod yn arholwr mewn arholiadau meddygol am y 15 mlynedd diwethaf. Rwy'n croesawu myfyrwyr yn rheolaidd ar raglen gyfnewid Erasmus. Dyfarnwyd Tystysgrif Rhagoriaeth Addysgu i mi gan Fwrdd Iechyd Prifysgol Caerdydd a'r Fro yn 2010. Rwy'n cyflwyno darlith flynyddol i israddedigion deintyddol ar anhwylderau steroid.
Ar lefel y DU, cynorthwyais i ddatblygu set o Safonau Cenedlaethol, a fabwysiadwyd ar y cyd gan y Gymdeithas Endocrinoleg, Cymdeithas Diabetolegwyr Clinigol Prydain (ABCD) a Diabetes UK, ar gyfer addysg israddedig mewn Endocrinoleg a Diabetes, wedi'i meincnodi yn erbyn Meddygon Yfory (2012). Yn 2015, golygais ac awdur Clinical Endocrinology and Diabetes at a Glance, cyfres testunau israddedig flaenllaw yn y DU mewn meddygaeth glinigol.
Ôl-raddedig
Fel arweinydd academaidd y Pwyllgor Hyfforddi Arbenigol ar gyfer Endocrinoleg a Diabetes yng Nghymru, sefydlais raglen addysgu niwroendocrin ar gyfer cofrestryddion arbenigol. Gyda chefnogaeth grant gan y Gymdeithas Endocrinoleg, cyflwynais sesiwn cyflwyno poster a datblygu gwobrau israddedig ac ôl-raddedig yng nghyfarfod blynyddol Cymdeithas Endocrin a Diabetes Cymru (WEDS). Yn dilyn hynny, fel cadeirydd WEDS, trefnais gyfarfod cyntaf y Gymdeithas Achosion Clinigol Rhanbarthol Endocrinoleg i'w gynnal yng Nghymru. Cefais fy newis fel Cynullydd ar gyfer cwrs Diweddariad Clinigol y Gymdeithas Endocrinoleg (2012-2018), lle gwnes i ddylunio a chyflwyno addysgu ar diwmorau niwroendocrin, neoplasia endocrin etifeddol, hyponatraemia a hypoglycaemia i dros 200 o Gofrestryddion Arbenigol ac Ymgynghorwyr bob blwyddyn. Roeddwn yn aelod o fwrdd Arholi Tystysgrif Arbenigedd Brenhinol y Meddygon ar gyfer Endocrinoleg a Diabetes (2020-2023) ac ar hyn o bryd rwy'n cyd-arwain ar gyfer adrannau Pituitary ac Adrenal rhaglen ESAP flynyddol Cymdeithas Endocrinaidd America.
I gydnabod fy ymrwymiad i addysgu israddedig ac ôl-raddedig, cefais fy ethol i Academi Addysgwyr Meddygol.
Bywgraffiad
Education and qualifications
- 2013: MAcadMEd
- 2010: FRCP, London
- 2002: PhD (Neuroendocrinology) University of Wales College of Medicine, Cardiff, UK
- 1996: MRCP, London
- 1993: MB, BCh (Hons), University of Wales College of Medicine, Cardiff, UK
Career overview
- 2015 - present: Reader in Neuroendocrinology and Honorary Consultant Endocrinologist, Neurosciences and Mental Health Research Institute, Cardiff University
- 2006 - 2015: Senior Lecturer and Honorary Consultant Endocrinologist, Cardiff University
- 2003 – 2006: Clinical Lecturer in Endocrinology, Cardiff University
- 2001 – 2003: Specialist Registrar in Endocrinology, South Wales
- 1998 – 2001: Society for Endocrinology Clinical Endocrinology Trust Research Fellow, University of Wales College of Medicine, Cardiff
- 1997 – 1998: Wellcome Trust Clinical Training Fellow, University of Wales College of Medicine, Cardiff
- 1996 – 1997: Registrar in General Medicine, Royal Gwent Hospital, Newport
- 1994 – 1996: Senior House Officer in Medicine, South Wales
- 1993 – 1994: House Officer in Medicine and Surgery, University Hospital of Wales and Llandough Hospital
Anrhydeddau a dyfarniadau
- 2005 - Novartis European Young Investigator Award. Nodweddu rôl kinases allgellog a reoleiddir gan signalau mewn gweithredu hormonau twf: mewnwelediadau o fwtaniadau genynnau hormon twf dynol newydd 1 (GH1).
- 2015 – 2017: Golygydd Cyswllt, Endocrinoleg Glinigol
- 2017 - 2024: Uwch Olygydd, Endocrinoleg Glinigol
- 2024 - 2027: Ysgrifennydd Cyffredinol, Cymdeithas endocrinoleg
Aelodaethau proffesiynol
- Fellow of the Royal College of Physicians
- Association of Physicians of Great Britain and Ireland
- Association of Clinical Professors of Medicine
- Society for Endocrinology (UK)
- The Endocrine Society (USA)
- European Society of Endocrinology
- European Neuroendocrine Tumour Society
- UK and Ireland Neuroendocrine Tumour Society
- British Medical Association
- Society of Physicians in Wales
Pwyllgorau ac adolygu
- 2011 - 2015: Aelod o Bwyllgor Gradd Uwch yr Ysgol Meddygaeth
- 2007 – 2010: Aelod o'r Grŵp Llywodraethu Ymchwil
Pwyllgorau allanol
- 2020 - presennol: Cynllun Hyfforddi Academaidd Clinigol Cymru ar y cyd yng Nghaerdydd
- 2018 - presennol: Cymdeithas Endocrinoleg Cyngor
- 2016 – presennol: Grŵp Arbenigedd Metabolaidd ac endocrin y Sefydliad Cenedlaethol ar gyfer Ymchwil Iechyd
- 2015 – 2018: Pwyllgor Cyllid Cymdeithas endocrinoleg
- 2018 – 2019: Bwrdd Cynghori Allanol DRU Cymru
- 2014 – 2024: Cadeirydd, Cymdeithas Endocrinaidd a Diabetes Cymru
- 2010 – presennol: Arweinydd Ymchwil a Datblygu, Bwrdd Meddygaeth, Bwrdd Iechyd Prifysgol Caerdydd a'r Fro
- 2015 – 2018: Aelod o Grŵp Gweithredol Uned Ymchwil Diabetes Cymru
- 2012 – 2018: Aelod cyfadran, Cyfarfod Diweddariad Clinigol y Gymdeithas Endocrinoleg
- 2014 – 2016: Bwrdd Golygyddol, Adroddiadau Gwyddonol
- 2012 – 2016: Aelod o Bwyllgor Clinigol y Gymdeithas Endocrinoleg
- 2011 – 2016: Aelod Pwyllgor Grŵp astudio Acromegaly y DU
- 2009 – 2013: Bwrdd Golygyddol, Endocrinoleg Glinigol
- 2007 – 2014: Aelod o'r Pwyllgor Hyfforddi Arbenigol, Endocrinoleg a Diabetes, Deoniaeth Cymru
- 2005 – 2014: Aelod Pwyllgor o Weithrediaeth Astudio Oedolion Cynhenid Hyperplasia Adrenal
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Contact Details
Themâu ymchwil
Arbenigeddau
- Endocrinoleg
