Professor Aled Rees
(he/him)
FRCP PhD MBBCh
Professor of Endocrinology, Neuroscience and Mental Health Innovation Institute
- Welsh speaking
Overview
I have a clinical and translational research interest in many aspects of endocrinology, with a particular focus on reproductive endocrinology, thyroid disease and steroid disorders.
My current studies use electronic health records, genetic analysis and advanced MRI to understand the impact of the hormonal environment in early life on long-term health outcomes. My group has characterised the long-term metabolic, mental health and cardiovascular outcomes of patients with Polycystic Ovary Syndrome (PCOS), and is exploring the impact of PCOS on health resource utilisation and economic burden. We have undertaken physiological studies to demonstrate altered cerebral microstructure, metabolism and cerebrovascular function in this population, and are examining the potential for exercise therapy and androgen blockade to modify these risks. I am currently leading the James Lind Alliance Priority Setting Partnership in PCOS.
Our long-term follow-up study of children born to mothers in the Controlled Antenatal Thyroid Screening (CATS) trial includes advanced MRI undertaken in the Cardiff University Brain Research Imaging Centre (CUBRIC) to explore the impact of altered maternal thyroid status on neurodevelopment. We have utilised the SAIL Databank to demonstrate an increased risk of cardiovascular events in patients with Resistance to Thyroid Hormone-Beta, with a view to exploring novel therapies that might mitigate this risk.
Our work in steroid disorders has demonstrated the value of salivary cortisol as an alternative to serum measurement for the diagnosis of adrenal insufficiency. We participate in clinical trials in Congenital Adrenal Hyperplasia which have brought new drugs to market, and are collaborating on multi-centre studies (CAHASE2) to characterise disease outcomes in this disorder.
Publication
2026
- Rees, S. and Rees, D. A. 2026. Prolactinomas: Clinical manifestations and therapy. In: Huhtaniemi, I. ed. Encyclopedia of Endocrine Diseases, 3rd Edition. Elsevier
2024
- Doyle, L. M. et al. 2024. Service evaluation suggests variation in clinical care provision in adults with congenital adrenal hyperplasia in the UK and Ireland. Clinical Endocrinology 101(4), pp. 386-396. (10.1111/cen.15043)
- Evans, C. et al. 2024. Current utility of first-line FT4 and TSH in screening for central hypothyroidism. Clinical Endocrinology 101(1), pp. 78-84. (10.1111/cen.15068)
- Rees, A. D. et al. 2024. Comparison of modified-release hydrocortisone capsules versus prednisolone in the treatment of congenital adrenal hyperplasia. Endocrine Connections 13(8), article number: e240150. (10.1530/EC-24-0150)
- Berni, T. R., Morgan, C. L. and Rees, D. A. 2024. Rising incidence, health resource utilization, and costs of polycystic ovary syndrome in the United Kingdom. Journal of Clinical Endocrinology and Metabolism (10.1210/clinem/dgae518)
- Scholz, A. et al. 2024. Controlled antenatal thyroid screening study III: Effects of gestational thyroid status on adolescent brain morphology. The Journal of Clinical Endocrinology & Metabolism (10.1210/clinem/dgae338)
- Green, K., MacIver, C. L., Ebden, S., Rees, D. A. and Peall, K. J. 2024. Pearls and Oy-sters: AARS2 leukodystrophy – tremor and tribulations. Neurology 102(8) (10.1212/WNL.0000000000209296)
- El-Farhan, N., Tennant, S., Rees, S. E., Evans, C. and Rees, D. A. 2024. Salivary cortisol response to ACTH stimulation is a reliable alternative to serum cortisol in evaluating hypoadrenalism. The Journal of Clinical Endocrinology & Metabolism 109(2), pp. e579-e588., article number: dgad576. (10.1210/clinem/dgad576)
2023
- Papanikolaou, N. et al. 2023. Clinical characteristics of functioning gonadotroph adenoma in women presenting with ovarian hyperstimulation: audit of UK pituitary centres. Clinical Endocrinology 99(4), pp. 386-395. (10.1111/cen.14949)
- Schröder, M. et al. 2023. Hormonal control during infancy and testicular adrenal rest tumor development in males with congenital adrenal hyperplasia: A retrospective multicenter cohort study. European journal of endocrinology 189(4), pp. 460-468. (10.1093/ejendo/lvad143)
- Dong, J. and Rees, D. A. 2023. Polycystic Ovary Syndrome: Pathophysiology and therapeutic opportunities. BMJ Medicine 2, article number: e000548. (10.1136/bmjmed-2023-000548)
- Berni, T., Morgan, C. and Rees, D. 2023. SAT357 Rising incidence, health resource utilization and costs of polycystic ovary syndrome in the United Kingdom. Journal of the Endocrine Society 7(S 1) (10.1210/jendso/bvad114.1662)
- Okosieme, O. et al. 2023. Cardiovascular morbidity and mortality in patients in Wales, UK with resistance to thyroid hormone β (RTHβ): a linked-record cohort study. The Lancet Diabetes & Endocrinology 11(9), pp. 657-666. (10.1016/S2213-8587(23)00155-9)
- Daughters, K., Unwin, K. and Rees, D. A. 2023. The psychological impact of adult-onset craniopharyngioma: A qualitative study of the experience of patients and clinicians. European Journal of Oncology Nursing 65, article number: 102346. (10.1016/j.ejon.2023.102346)
- Elhassan, Y. S. et al. 2023. COVID-19-related Adrenal haemorrhage multicentre UK experience and systematic review of the literature. Clinical Endocrinology 98(6), pp. 766-778. (10.1111/cen.14881)
- Taylor, P., Lansdown, A., Witczak, J., Khan, R., Rees, A., Dayan, C. and Okosieme, O. 2023. Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice. Thyroid Research 16, article number: 7. (10.1186/s13044-023-00149-5)
- Tschaidse, L. et al. 2023. Modified-release hydrocortisone is associated with lower plasma renin activity in patients with salt-wasting congenital adrenal hyperplasia. European Journal of Endocrinology 188(1), article number: lvac006. (10.1093/ejendo/lvac006)
2022
- Daughters, K., Rees, A. and Unwin, K. 2022. ODP365 The psychological impact of adult-onset craniopharyngioma: the experience of patients and clinicians. Journal of the Endocrine Society 6(S1), article number: A516. (10.1210/jendso/bvac150.1073)
- Perros, P. et al. 2022. Post-radioiodine Graves' management: the PRAGMA study. Clinical Endocrinology 97(5), pp. 664-675. (10.1111/cen.14719)
- Panagiotou, G., Taylor, P. N., Rees, D. A. and Okosieme, O. E. 2022. Late offspring effects of antenatal thyroid screening. British Medical Bulletin 143(1), pp. 16-29. (10.1093/bmb/ldac018)
- Allen, L., Shrikrishnapalasuriyar, N. and Rees, D. A. 2022. Long-term health outcomes in young women with Polycystic Ovary Syndrome: a narrative review. Clinical Endocrinology 97(2), pp. 187-198. (10.1111/cen.14609)
- Daughters, K., Rees, A., Hunnikin, L., Wells, A., Hall, J. and van Goozen, S. 2022. Oxytocin administration versus emotion training in healthy males: Considerations for future research. Philosophical Transactions of the Royal Society B: Biological Sciences 377(1858), article number: 20210056. (10.1098/rstb.2021.0056)
- McCarthy, O. et al. 2022. Passing on the exercise baton: What can endocrine patients learn from elite athletes?. Clinical Endocrinology 96(6), pp. 781-792. (10.1111/cen.14683)
- Whelan, C., Burnley-Hall, N., Morris, K., Rees, D. A. and James, P. E. 2022. The procoagulant effects of extracellular vesicles derived from hypoxic endothelial cells can be selectively inhibited by inorganic nitrite. Nitric Oxide: Biology and Chemistry 122-12, pp. 6-18. (10.1016/j.niox.2022.02.002)
- Cauldwell, M. et al. 2022. Pregnancies in women with Turner Syndrome: A retrospective multicentre UK study. BJOG: An International Journal of Obstetrics and Gynaecology 129, pp. 796-803. (10.1111/1471-0528.17025)
2021
- Zhang, L. et al. 2021. The role of mitochondria-linked fatty-acid uptake-driven adipogenesis in Graves’ Orbitopathy. Endocrinology 162(12), article number: bqab188. (10.1210/endocr/bqab188)
- Draman, M. S. et al. 2021. Expression of endogenous putative TSH binding protein in orbit. Current Issues in Molecular Biology 43(3), pp. 1794-1804. (10.3390/cimb43030126)
- Berni, T. R., Morgan, C. L. and Rees, D. A. 2021. Women with Polycystic Ovary Syndrome have an increased risk of major cardiovascular events: a population study. Journal of Clinical Endocrinology and Metabolism 106(9), pp. e3369-e3380. (10.1210/clinem/dgab392)
- Connolly, K. D., Rees, D. A. and James, P. E. 2021. Role of adipocyte-derived extracellular vesicles in vascular inflammation. Free Radical Biology and Medicine 172, pp. 58-64. (10.1016/j.freeradbiomed.2021.04.031)
- Richards, C. T., Meah, V. L., James, P. E., Rees, D. A. and Lord, R. N. 2021. HIIT’ing or MISS’ing the optimal management of polycystic ovary syndrome: a systematic review and meta-analysis of high- versus moderate-intensity exercise prescription. Frontiers in Physiology 12, article number: 715881. (10.3389/fphys.2021.715881)
- Merke, D. P. et al. 2021. Modified-release hydrocortisone in congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism 106(5), pp. e2063-e2077. (10.1210/clinem/dgab051)
- Thomas, M. et al. 2021. Insulin‐like growth factor‐1, growth hormone and disease outcomes in acromegaly: a population study. Clinical Endocrinology 95(1), pp. 143-152. (10.1111/cen.14468)
- Chambers, T. et al. 2021. Effects of thyroid status on regional brain volumes: a diagnostic and genetic imaging study in UK Biobank. Journal of Clinical Endocrinology and Metabolism 106(3), pp. 688-696. (10.1210/clinem/dgaa903)
- Lewis, R. D., Narayanaswamy, A. K., Farewell, D. and Rees, D. A. 2021. Complement activation in polycystic ovary syndrome occurs in the post-prandial and fasted state, and is influenced by obesity and insulin sensitivity. Clinical Endocrinology 94(1), pp. 74-84. (10.1111/cen.14322)
2020
- Zhang, L. et al. 2020. Distinctive features of orbital adipose tissue (OAT) in Graves' orbitopathy. International Journal of Molecular Sciences 21(23), article number: 9145. (10.3390/ijms21239145)
- Pak, H. Y., Lansdown, A., Taylor, P., Rees, A. D., Davies, J. and Hayhurst, C. 2020. Acromegaly and the information gap: patient perceptions of the journey from primary to tertiary care. Endocrine Connections 9(10), pp. 971-977. (10.1530/EC-20-0335)
- Galloway, L., Ali, M., Lansdown, A., Taylor, P., Rees, A., Davies, J. S. and Hayhurst, C. 2020. The impact of endoscopic transsphenoidal pituitary adenoma surgery on endocrine function: a single-centre study. Acta Neurochirurgica 163(2), pp. 391-398. (10.1007/s00701-020-04609-x)
- Muller, I. et al. 2020. CATS II long-term anthropometric and metabolic effects of maternal sub-optimal thyroid function in offspring and mothers. Journal of Clinical Endocrinology and Metabolism 105(7), article number: dgaa129. (10.1210/clinem/dgaa129)
- Ellins, E., Shipley, M., Rees, D., Kemp, A., Deanfield, J., Brunner, E. and Halcox, J. 2020. Associations of depression-anxiety and dyslipidaemia with subclinical carotid arterial disease: Findings from the Whitehall II Study. European Journal of Preventive Cardiology 27(8), pp. 800-807. (10.1177/2047487319876230)
- Napier, C. et al. 2020. Residual adrenal function in autoimmune addison's disease - effect of dual therapy with rituximab and depot tetracosactide. Journal of Clinical Endocrinology and Metabolism 105(4), article number: Volume 105, Issue 4, April 2020,. (10.1210/clinem/dgz287)
- Hayhurst, C., Taylor, P., Lansdown, A., Palaniappan, N., Rees, D. and Davis, J. 2020. Current perspectives on recurrent pituitary adenoma: the role and timing of surgery vs adjuvant treatment. Clinical Endocrinology 92(2), pp. 89-97. (10.1111/cen.14127)
2019
- Lansdown, A., Warbert, E., Sverrisdottir, Y., Wise, R. and Rees, D. 2019. Regional cerebral activation accompanies sympathoexcitation in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 104(9), pp. 3614-3623. (10.1210/jc.2019-00065)
- Wilson, N. et al. 2019. Role of hyaluronan in human adipogenesis: Evidence from in-vitro and in-vivo studies. International Journal of Molecular Sciences 20(11), article number: 2675. (10.3390/ijms20112675)
- Wadey, R. M., Connolly, K. D., Mathew, D., Walters, G., Rees, D. A. and James, P. E. 2019. Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells. Atherosclerosis 283, pp. 19-27. (10.1016/j.atherosclerosis.2019.01.013)
- Bhargava, R., Daughters, K. L. and Rees, D. A. 2019. Oxytocin therapy in hypopituitarism: challenges and opportunities. Clinical Endocrinology 90(2), pp. 257-264. (10.1111/cen.13909)
2018
- Scholz, A. and Rees, D. A. 2018. Prolactinomas: Clinical manifestations and therapy. In: Huhtaniemi, I. and Martini, L. eds. Encyclopedia of Endocrine Diseases (Second Edition). Elsevier, pp. 319-324., (10.1016/B978-0-12-801238-3.65181-4)
- Connolly, K. D., Wadey, R. M., Mathew, D., Johnson, E., Rees, D. A. and James, P. E. 2018. Evidence for adipocyte-derived extracellular vesicles in the human circulation. Endocrinology 159(9), pp. 3259-3267. (10.1210/en.2018-00266)
- Trainer, P. J. et al. 2018. A randomised, open-label, parallel group phase 2 study of antisense oligonucleotide therapy in acromegaly. European Journal of Endocrinology 179(2), pp. 97-108. (10.1530/EJE-18-0138)
- Berni, T., Morgan, C., Berni, E. and Rees, D. A. 2018. Polycystic ovary syndrome is associated with adverse mental health and neurodevelopmental outcomes. Journal of Clinical Endocrinology and Metabolism 103(6), pp. 2116-2125. (10.1530/endoabs.50.P353)
- Hales, C. et al. 2018. Controlled antenatal thyroid screening II: effect of treating maternal sub-optimal thyroid function on child cognition. Journal of Clinical Endocrinology and Metabolism 103(4), pp. 1583-1591. (10.1210/jc.2017-02378)
- Rees, D. A. 2018. Tips from the shop floor: Addisonian crisis - assessment and management. British Journal of Hospital Medicine 79(3), pp. 34-37. (10.12968/hmed.2018.79.3.C34)
- Witczak, J. K., Min, T., Prior, S. L., Stephens, J. W., James, P. E. and Rees, D. 2018. Bariatric surgery is accompanied by changes in extracellular vesicle-associated and plasma fatty acid binding protein 4. Obesity Surgery 28(3), pp. 767-774. (10.1007/s11695-017-2879-z)
- Burnley-Hall, N. et al. 2018. Dietary nitrate supplementation reduces circulating platelet-derived extracellular vesicles in coronary artery disease patients on clopidogrel therapy: a randomised, double-blind, placebo-controlled study. Thrombosis and Haemostasis 118(1), pp. 112-122. (10.1160/TH17-06-0394)
2017
- Hubble, K., Daughters, K., Manstead, A., Rees, D., Thapar, A. and Van Goozen, S. 2017. Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear. Neuropsychologia 106, pp. 350-357. (10.1016/j.neuropsychologia.2017.10.019)
- Daughters, K., Manstead, A. S. R. and Rees, D. A. 2017. Hypopituitarism is associated with lower oxytocin concentrations and reduced empathic ability. Endocrine 57(1), pp. 166-174. (10.1007/s12020-017-1332-3)
- Taylor, P. N. et al. 2017. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study. Journal of Clinical Endocrinology and Metabolism 102(7), pp. 2508-2515. (10.1210/jc.2016-3605)
- Taylor, P. et al. 2017. Cerebral salt wasting following traumatic brain injury. Endocrinology, Diabetes & Metabolism Case Reports (10.1530/EDM-16-0142)
- Arlt, W. et al. 2017. Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism. JCI Insight 2(8), article number: e93136. (10.1172/jci.insight.93136)
- El-Farhan, N., Rees, D. A. and Evans, C. 2017. ANNALS EXPRESS: Measuring cortisol in serum, urine and saliva – are our assays good enough?. Annals of Clinical Biochemistry 54(3), pp. 308-322. (10.1177/0004563216687335)
- Draman, M. S., Stechman, M., Scott-Coombes, D., Dayan, C. M., Rees, D. A., Ludgate, M. and Zhang, L. 2017. The role of thyrotropin receptor activation in adipogenesis and modulation of fat phenotype. Frontiers in Endocrinology 8, article number: 83. (10.3389/fendo.2017.00083)
- Burnley-Hall, N., Willis, G., Davis, J., Rees, D. A. and James, P. E. 2017. Nitrite-derived nitric oxide reduces hypoxia-inducible factor 1α-mediated extracellular vesicle production by endothelial cells. Nitric Oxide: Biology and Chemistry 63, pp. 1-12. (10.1016/j.niox.2016.12.005)
- Ellins, E. A., Rees, D. A., Deanfield, J. E., Steptoe, A. and Halcox, J. P. 2017. Increased fibrinogen responses to psychophysiological stress predict future endothelial dysfunction implications for cardiovascular disease?. Brain, Behavior, and Immunity 60, pp. 233-239. (10.1016/j.bbi.2016.10.017)
2016
- Hubble, K., Daughters, K., Manstead, A., Rees, D. A., Thapar, A. and Van Goozen, S. 2016. Oxytocin reduces face processing time but leaves recognition accuracy and eye-gaze unaffected. Journal of the International Neuropsychological Society 23(1), pp. 23-33. (10.1017/S1355617716000886)
- Drake, W. M. et al. 2016. A follow-up study of the prevalence of valvular heart abnormalities in hyperprolactinemic patients treated with cabergoline. Journal of Clinical Endocrinology & Metabolism 101(11), pp. 4189-4194. (10.1210/jc.2016-2224)
- Bondugulapati, L. and Rees, D. A. 2016. Inhaled corticosteroids and HPA axis suppression: how important is it and how should it be managed?. Clinical Endocrinology 85(2), pp. 165-169. (10.1111/cen.13073)
- Rees, D. A., Jenkins-Jones, S. and Morgan, C. L. 2016. Contemporary reproductive outcomes for patients with polycystic ovary syndrome: a retrospective observational study. Journal of Clinical Endocrinology & Metabolism 101(4), pp. 1664-1672. (10.1210/jc.2015-2682)
- Roy Chowdhury, S. et al. 2016. Diabetic retinopathy in newly diagnosed subjects with type 2 diabetes mellitus: contribution of β-Cell function. Journal of Clinical Endocrinology and Metabolism 101(2), pp. 572-580. (10.1210/jc.2015-2203)
- Taylor, P. et al. 2016. Paradoxical relationship between body mass index and thyroid hormone levels: a study using Mendelian randomization. Journal of Clinical Endocrinology & Metabolism 101(2), pp. 730-738. (10.1210/jc.2015-3505)
- Rees, D. A., Udiawar, M., Berlot, R., Jones, D. K. and O'Sullivan, M. J. 2016. White matter microstructure and cognitive function in young women with polycystic ovary syndrome. Journal of Clinical Endocrinology & Metabolism 101(1), pp. 314-323. (10.1210/jc.2015-2318)
2015
- Daughters, K., Manstead, A. S. R., Hubble, K., Rees, D. A., Thapar, A. and Van Goozen, S. H. M. 2015. Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study. PLoS ONE 10(12), article number: e0145104. (10.1371/journal.pone.0145104)
- Connolly, K. D. et al. 2015. Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis. Journal of Extracellular Vesicles 4(s1), article number: 29159. (10.3402/jev.v4.29159)
- Grant, P. et al. 2015. Response to 'How we define hyponatremia'?. European Journal of Clinical Investigation 45(11), pp. 1218. (10.1111/eci.12515)
- Daniel, E. et al. 2015. Effectiveness of metyrapone in treating Cushing's Syndrome: a retrospective multicenter study in 195 patients. Journal of Clinical Endocrinology & Metabolism 100(11), pp. 4146. (10.1210/jc.2015-2616)
- Bondugulapati, L. N. R., Campbell, C., Chowdhury, S. R., Goetz, P., Davies, J. S., Rees, D. A. and Hayhurst, C. 2015. Use of day 1 early morning cortisol to predict the need for glucocorticoid replacement after pituitary surgery. British Journal of Neurosurgery 30(1), pp. 76-79. (10.3109/02688697.2015.1071325)
- Ellins, E. . A. et al. 2015. Validation of a new method for non-invasive assessment of vasomotor function. European Journal of Preventive Cardiology 23(6), pp. 577-583. (10.1177/2047487315597210)
- Margulescu, A. D., Rees, E., Coulson, R., Rees, D. A., Vinereanu, D. and Fraser, A. G. 2015. Do left atrial strain and strain rate reflect intrinsic atrial function, or are they determined by left ventricular function?. Kardiologia Polska 73(7), pp. 539-548. (10.5603/KP.a2015.0035)
- Grant, P. et al. 2015. The diagnosis and management of inpatient hyponatraemia and SIADH. European Journal of Clinical Investigation 45(8), pp. 888-894. (10.1111/eci.12465)
- Dénes, J. et al. 2015. Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a large patient cohort. Journal of Clinical Endocrinology & Metabolism 100(3), pp. E531. (10.1210/jc.2014-3399)
2014
- Willis, G. R. et al. 2014. Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles. Human Reproduction 29(12), pp. 2756-2763. (10.1093/humrep/deu281)
- Willis, G. R., Udiawar, M., Evans, W. D., Blundell, H. L., James, P. E. and Rees, D. A. 2014. Detailed characterisation of circulatory nitric oxide and free radical indices-is there evidence for abnormal cardiovascular homeostasis in young women with polycystic ovary syndrome?. BJOG: An International Journal of Obstetrics and Gynaecology 121(13), pp. 1596-1603. (10.1111/1471-0528.12834)
- Connolly, K. D. et al. 2014. Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia. Journal of Lipid Research 55, pp. 2064-2072. (10.1194/jlr.M049726)
- Muller, I. and Rees, D. A. 2014. Melasma and endocrine disorders. Journal of Pigmentary Disorders S1, article number: 1. (10.4172/2376-0427.1000S1001)
- Gagliardi, L. et al. 2014. ARMC5 mutations are common in familial bilateral macronodular adrenal hyperplasia. Journal of Clinical Endocrinology & Metabolism 99(9), article number: E1784. (10.1210/jc.2014-1265)
- Rees, E. et al. 2014. Central arterial stiffness and diastolic dysfunction are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk. Human Reproduction 29(9), pp. 2041-2049. (10.1093/humrep/deu180)
- Han, T. S. et al. 2014. Relationship between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE). Journal of Clinical Endocrinology & Metabolism 99(8), pp. E1547-E1555. (10.1210/jc.2014-1486)
- Evans, C., El-Farhan, N., Ducroq, D. and Rees, D. A. 2014. Response to 'Determining the utility of the 60-min cortisol measurement in the short Synacthen test'. Clinical Endocrinology 80(5), pp. 766-767. (10.1111/cen.12272)
- Dodd, A. et al. 2014. The effect of serum matrix and gender on cortisol measurement by commonly used immunoassays. Annals of Clinical Biochemistry 51(3), pp. 379-385. (10.1177/0004563213514567)
- Ibrahim, R., Kalhan, A., Lammie, A., Kotonya, C., Nannapanenni, R. and Rees, D. R. 2014. Dense calcification in a GH-secreting pituitary macroadenoma. Endocrinology, Diabetes & Metabolism Case Reports, article number: EDM130079. (10.1530/EDM-13-0079)
- Hales, C. et al. 2014. The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol. BMC Endocrine Disorders 14(1), article number: 95. (10.1186/1472-6823-14-95)
2013
- Owen, L. J. et al. 2013. Development of a rapid assay for the analysis of serum cortisol and its implementation into a routine service laboratory. Annals of Clinical Biochemistry 50(4), pp. 345-352. (10.1177/0004563212473448)
- Han, T. S. et al. 2013. Quality of life in adults with congenital adrenal hyperplasia relates to glucocorticoid treatment, adiposity and insulin resistance: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE). European Journal of Endocrinology 168(6), pp. 887-893. (10.1530/EJE-13-0128)
- El-Farhan, N. et al. 2013. Method-specific serum cortisol responses to the adrenocorticotrophin test: comparison of gas chromatography-mass spectrometry and five automated immunoassays. Clinical Endocrinology 78(5), pp. 673-680. (10.1111/cen.12039)
- Al-Sarireh, B., Haidermota, M., Verbeke, C., Rees, D. A., Yu, R. and Griffiths, A. 2013. Glucagon cell adenomatosis without glucagon receptor mutation [letter]. Pancreas 42(2), pp. 360-362. (10.1097/MPA.0b013e31825b6acd)
- Neale, S. M., Hocking, R., Biswas, M., Turkes, A., Rees, D., Rees, D. A. and Evans, C. 2013. Adult testosterone and calculated free testosterone reference ranges by tandem mass spectrometry. Annals of Clinical Biochemistry 50(2), pp. 159-161. (10.1258/acb.2012.012047)
- Han, T. S. et al. 2013. Glucocorticoid treatment regimen and health outcomes in adults with congenital adrenal hyperplasia. Clinical Endocrinology 78(2), pp. 197-203. (10.1111/cen.12045)
- Das, G., Eligar, V. S., Govindan, J. and Rees, D. A. 2013. Late presentation of hyperandrogenism in pregnancy: clinical features and differential diagnosis. Endocrinology, Diabetes & Metabolism Case Reports 10, article number: EDM130048. (10.1530/EDM-13-0048)
2012
- Lansdown, A. and Rees, D. A. 2012. The sympathetic nervous system in polycystic ovary syndrome: a novel therapeutic target?. Clinical Endocrinology 77(6), pp. 791-801. (10.1111/cen.12003)
- Lunenfeld, B., Arver, S., Moncada, I., Rees, D. A. and Schulte, H. M. 2012. How to help the aging male? Current approaches to hypogonadism in primary care. The Aging Male 15(4), pp. 187-197. (10.3109/13685538.2012.729110)
- Morgan, C. L., Jenkins-Jones, S., Currie, C. J. and Rees, D. A. 2012. Evaluation of adverse outcome in young women with polycystic ovary syndrome versus matched, reference controls: a retrospective, observational study. Journal of Clinical Endocrinology & Metabolism 97(9), pp. 3251-3260. (10.1210/jc.2012-1690)
- Kalhan, A. et al. 2012. Adenosine A2A and A2B receptor expression in neuroendocrine tumours: potential targets for therapy. Purinergic Signalling 8(2), pp. 265-274. (10.1007/s11302-011-9280-5)
- Zhang, L., Grennan-Jones, F. A., Lane, C., Rees, D. A., Dayan, C. M. and Ludgate, M. E. 2012. Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy. Journal of Clinical Endocrinology & Metabolism 97(2), pp. 653-662. (10.1210/jc.2011-1299)
- Lansdown, A. J., Ludgate, M. E. and Rees, D. A. 2012. Metabolic syndrome: is the preadipocyte to blame? [Commentary]. Clinical Endocrinology 76(1), pp. 19-20. (10.1111/j.1365-2265.2011.04176.x)
- Biswas, M., Hampton, D., Newcombe, R. G. and Rees, D. A. 2012. Total and free testosterone concentrations are strongly influenced by age and central obesity in men with type 1 and type 2 diabetes but correlate weakly with symptoms of androgen deficiency and diabetes-related quality of life. Clinical Endocrinology 76(5), pp. 665-673. (10.1111/j.1365-2265.2011.04196.x)
2011
- Lansdown, A. J. and Rees, D. A. 2011. Endocrine oncology in pregnancy. Best Practice & Research Clinical Endocrinology & Metabolism 25(6), pp. 911-926. (10.1016/j.beem.2011.06.011)
- Rice, S. J. and Rees, D. A. 2011. DHEA and vascular function. In: Watson, R. R. ed. DHEA in Human Health and Aging. Boca Raton, Fl: CRC Press, pp. 375-388.
- Stephens, M. W., Ludgate, M. E. and Rees, D. A. 2011. Brown fat and obesity: the next big thing?. Clinical Endocrinology 74(6), pp. 661-670. (10.1111/j.1365-2265.2011.04018.x)
2010
- Wiebke, A. et al. 2010. Health status of adults with congenital adrenal hyperplasia: A cohort study of 203 patients. Journal of Clinical Endocrinology & Metabolism 95(11), pp. 5110-5121. (10.1210/jc.2010-0917)
- Biswas, M., Hampton, D., Turkes, A., Newcombe, R. G. and Rees, D. A. 2010. Reduced total testosterone concentrations in young healthy South Asian men are partly explained by increased insulin resistance but not by altered adiposity. Clinical Endocrinology 73(4), pp. 457-462. (10.1111/j.1365-2265.2010.03824.x)
- Agarwal, N., Rice, S. P. L., Bolusani, H., Luzio, S. D., Dunseath, G. J., Ludgate, M. E. and Rees, D. A. 2010. Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: A randomized, placebo-controlled, crossover trial. Obstetrical & Gynecological Survey 65(6), pp. 381-382. (10.1097/OGX.0b013e3181e5a167)
- Rice, S. P. L., Zhang, L., Grennan-Jones, F. A., Agarwal, N., Lewis, M. D., Rees, D. A. and Ludgate, M. E. 2010. Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue. Molecular and Cellular Endocrinology 320(1-2), pp. 51-57. (10.1016/j.mce.2010.02.017)
- De Lloyd, A. C., Bursell, J. D. H., Gregory, J. W., Rees, D. A. and Ludgate, M. E. 2010. TSH receptor activation and body composition. Journal of Endocrinology 204(1), pp. 13-20. (10.1677/JOE-09-0262)
- Rees, D. A. and Dayan, C. M. 2010. Commentary: Testosterone and the metabolic syndrome: cause or consequence?. International Journal of Epidemiology 40(1), pp. 207-209. (10.1093/ije/dyq254)
- Agarwal, N., Rice, S. P. L., Bolusani, H., Luzio, S. D., Dunseath, G., Ludgate, M. and Rees, D. A. 2010. Metformin Reduces Arterial Stiffness and Improves Endothelial Function in Young Women with Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled, Crossover Trial. Journal of Clinical Endocrinology & Metabolism 95(2), pp. 722-730. (10.1210/jc.2009-1985)
2009
- Krone, N. et al. 2009. Current management, morbidity and genotypephenotype correlation in adults with congenital adrenal hyperplasia – analysis of the United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE) cohort [Abstract]. Hormone Research 72(S3), pp. 41-41. (10.1159/000239668)
- Rice, S. P. L., Agarwal, N., Bolusani, H., Newcombe, R. G., Scanlon, M. F., Ludgate, M. E. and Rees, D. A. 2009. Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: A randomized crossover trial. Journal of Clinical Endocrinology & Metabolism 94(6), pp. 1966-1972. (10.1210/jc.2008-2636)
- Rees, D. A., Giles, P. J., Lewis, M. D. and Ham, J. 2009. Adenosine regulates thrombomodulin and endothelial protein C receptor expression in folliculostellate cells of the pituitary gland. Purinergic Signalling 6(1), pp. 19-29. (10.1007/s11302-009-9172-0)
- Watson, S., Blundell, H. L., Evans, W., Griffiths, H., Newcombe, R. G. and Rees, D. A. 2009. Can abdominal bioelectrical impedance refine the determination of visceral fat from waist circumference?. Physiological Measurement 30(7), pp. N53-N58. (10.1088/0967-3334/30/7/N01)
- Colao, A. et al. 2009. Octreotide LARvs.surgery in newly diagnosed patients with acromegaly: a randomized, open-label, multicentre study. Clinical Endocrinology 70(5), pp. 757-768. (10.1111/j.1365-2265.2008.03441.x)
2008
- Ham, J. and Rees, D. A. 2008. The adenosine a2b receptor: its role in inflammation. Endocrine‚ Metabolic & Immune Disorders - Drug Targets 8(4), pp. 244-254.
- Millar, D. S. et al. 2008. Growth hormone (GH1) gene variation and the growth hormone receptor (GHR) exon 3 deletion polymorphism in a West-African population. Molecular and Cellular Endocrinology 296(1-2), pp. 18-25. (10.1016/j.mce.2008.09.023)
- Scanlon, M. F. and Rees, D. A. eds. 2008. Specialist training in endocrinology. Edinburgh: Mosby/Elsevier,.
2007
- Cozma, I., Zhang, L., Uddin, J., Lane, C., Rees, D. A. and Ludgate, M. E. 2007. Modulation of expression of somatostatin receptor subtypes in Graves' opthalmopathy orbits : relevance to novel analogues. American Journal of Physiology. Endocrinology and Metabolism (10.1152/ajpendo.00177.2007)
2006
- Lewis, B. M. et al. 2006. Adenosine stimulates connexin 43 expression and gap junctional communication in pituitary folliculostellate cells. The FASEB Journal 20(14), pp. 2585-2587. (10.1096/fj.06-6121fje)
2003
- Rees, D. A., Lewis, B. M., Lewis, M. D., Francis, K., Scanlon, M. F. and Ham, J. 2003. Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK. British Journal of Pharmacology 140(4), pp. 764-72. (10.1038/sj.bjp.0705488)
- De, P. et al. 2003. Transsphenoidal surgery for acromegaly in Wales: results based on stringent criteria of remission. Journal of Clinical Endocrinology & Metabolism 88(8), pp. 3567-72. (10.1210/jc.2002-021822)
2002
- Rees, D. A., Gayle, C., Gaillard, R. C. and Fear, S. 2002. Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults. Journal of Clinical Endocrinology & Metabolism 87(6), pp. 2725-33. (10.1210/jc.87.6.2725)
- Rees, D. A., Lewis, M. D., Lewis, B. M., Smith, P. J., Scanlon, M. F. and Ham, J. 2002. Adenosine-regulated cell proliferation in pituitary folliculostellate and endocrine cells: differential roles for the A(1) and A(2B) adenosine receptors. Endocrinology 143(6), pp. 2427-2436. (10.1210/en.143.6.2427)
1992
- Clarke, A. J., Bradley, D. M., Gillespie, K., Rees, D. A., Holland, A. and Thomas, N. S. T. 1992. Fragile X mental retardation and the iduronate sulphatase locus: testing laird's model of fra(X) inheritance. American Journal of Medical Genetics 43(1-2), pp. 299-306. (10.1002/ajmg.1320430146)
Articles
- Doyle, L. M. et al. 2024. Service evaluation suggests variation in clinical care provision in adults with congenital adrenal hyperplasia in the UK and Ireland. Clinical Endocrinology 101(4), pp. 386-396. (10.1111/cen.15043)
- Evans, C. et al. 2024. Current utility of first-line FT4 and TSH in screening for central hypothyroidism. Clinical Endocrinology 101(1), pp. 78-84. (10.1111/cen.15068)
- Rees, A. D. et al. 2024. Comparison of modified-release hydrocortisone capsules versus prednisolone in the treatment of congenital adrenal hyperplasia. Endocrine Connections 13(8), article number: e240150. (10.1530/EC-24-0150)
- Berni, T. R., Morgan, C. L. and Rees, D. A. 2024. Rising incidence, health resource utilization, and costs of polycystic ovary syndrome in the United Kingdom. Journal of Clinical Endocrinology and Metabolism (10.1210/clinem/dgae518)
- Scholz, A. et al. 2024. Controlled antenatal thyroid screening study III: Effects of gestational thyroid status on adolescent brain morphology. The Journal of Clinical Endocrinology & Metabolism (10.1210/clinem/dgae338)
- Green, K., MacIver, C. L., Ebden, S., Rees, D. A. and Peall, K. J. 2024. Pearls and Oy-sters: AARS2 leukodystrophy – tremor and tribulations. Neurology 102(8) (10.1212/WNL.0000000000209296)
- El-Farhan, N., Tennant, S., Rees, S. E., Evans, C. and Rees, D. A. 2024. Salivary cortisol response to ACTH stimulation is a reliable alternative to serum cortisol in evaluating hypoadrenalism. The Journal of Clinical Endocrinology & Metabolism 109(2), pp. e579-e588., article number: dgad576. (10.1210/clinem/dgad576)
- Papanikolaou, N. et al. 2023. Clinical characteristics of functioning gonadotroph adenoma in women presenting with ovarian hyperstimulation: audit of UK pituitary centres. Clinical Endocrinology 99(4), pp. 386-395. (10.1111/cen.14949)
- Schröder, M. et al. 2023. Hormonal control during infancy and testicular adrenal rest tumor development in males with congenital adrenal hyperplasia: A retrospective multicenter cohort study. European journal of endocrinology 189(4), pp. 460-468. (10.1093/ejendo/lvad143)
- Dong, J. and Rees, D. A. 2023. Polycystic Ovary Syndrome: Pathophysiology and therapeutic opportunities. BMJ Medicine 2, article number: e000548. (10.1136/bmjmed-2023-000548)
- Berni, T., Morgan, C. and Rees, D. 2023. SAT357 Rising incidence, health resource utilization and costs of polycystic ovary syndrome in the United Kingdom. Journal of the Endocrine Society 7(S 1) (10.1210/jendso/bvad114.1662)
- Okosieme, O. et al. 2023. Cardiovascular morbidity and mortality in patients in Wales, UK with resistance to thyroid hormone β (RTHβ): a linked-record cohort study. The Lancet Diabetes & Endocrinology 11(9), pp. 657-666. (10.1016/S2213-8587(23)00155-9)
- Daughters, K., Unwin, K. and Rees, D. A. 2023. The psychological impact of adult-onset craniopharyngioma: A qualitative study of the experience of patients and clinicians. European Journal of Oncology Nursing 65, article number: 102346. (10.1016/j.ejon.2023.102346)
- Elhassan, Y. S. et al. 2023. COVID-19-related Adrenal haemorrhage multicentre UK experience and systematic review of the literature. Clinical Endocrinology 98(6), pp. 766-778. (10.1111/cen.14881)
- Taylor, P., Lansdown, A., Witczak, J., Khan, R., Rees, A., Dayan, C. and Okosieme, O. 2023. Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice. Thyroid Research 16, article number: 7. (10.1186/s13044-023-00149-5)
- Tschaidse, L. et al. 2023. Modified-release hydrocortisone is associated with lower plasma renin activity in patients with salt-wasting congenital adrenal hyperplasia. European Journal of Endocrinology 188(1), article number: lvac006. (10.1093/ejendo/lvac006)
- Daughters, K., Rees, A. and Unwin, K. 2022. ODP365 The psychological impact of adult-onset craniopharyngioma: the experience of patients and clinicians. Journal of the Endocrine Society 6(S1), article number: A516. (10.1210/jendso/bvac150.1073)
- Perros, P. et al. 2022. Post-radioiodine Graves' management: the PRAGMA study. Clinical Endocrinology 97(5), pp. 664-675. (10.1111/cen.14719)
- Panagiotou, G., Taylor, P. N., Rees, D. A. and Okosieme, O. E. 2022. Late offspring effects of antenatal thyroid screening. British Medical Bulletin 143(1), pp. 16-29. (10.1093/bmb/ldac018)
- Allen, L., Shrikrishnapalasuriyar, N. and Rees, D. A. 2022. Long-term health outcomes in young women with Polycystic Ovary Syndrome: a narrative review. Clinical Endocrinology 97(2), pp. 187-198. (10.1111/cen.14609)
- Daughters, K., Rees, A., Hunnikin, L., Wells, A., Hall, J. and van Goozen, S. 2022. Oxytocin administration versus emotion training in healthy males: Considerations for future research. Philosophical Transactions of the Royal Society B: Biological Sciences 377(1858), article number: 20210056. (10.1098/rstb.2021.0056)
- McCarthy, O. et al. 2022. Passing on the exercise baton: What can endocrine patients learn from elite athletes?. Clinical Endocrinology 96(6), pp. 781-792. (10.1111/cen.14683)
- Whelan, C., Burnley-Hall, N., Morris, K., Rees, D. A. and James, P. E. 2022. The procoagulant effects of extracellular vesicles derived from hypoxic endothelial cells can be selectively inhibited by inorganic nitrite. Nitric Oxide: Biology and Chemistry 122-12, pp. 6-18. (10.1016/j.niox.2022.02.002)
- Cauldwell, M. et al. 2022. Pregnancies in women with Turner Syndrome: A retrospective multicentre UK study. BJOG: An International Journal of Obstetrics and Gynaecology 129, pp. 796-803. (10.1111/1471-0528.17025)
- Zhang, L. et al. 2021. The role of mitochondria-linked fatty-acid uptake-driven adipogenesis in Graves’ Orbitopathy. Endocrinology 162(12), article number: bqab188. (10.1210/endocr/bqab188)
- Draman, M. S. et al. 2021. Expression of endogenous putative TSH binding protein in orbit. Current Issues in Molecular Biology 43(3), pp. 1794-1804. (10.3390/cimb43030126)
- Berni, T. R., Morgan, C. L. and Rees, D. A. 2021. Women with Polycystic Ovary Syndrome have an increased risk of major cardiovascular events: a population study. Journal of Clinical Endocrinology and Metabolism 106(9), pp. e3369-e3380. (10.1210/clinem/dgab392)
- Connolly, K. D., Rees, D. A. and James, P. E. 2021. Role of adipocyte-derived extracellular vesicles in vascular inflammation. Free Radical Biology and Medicine 172, pp. 58-64. (10.1016/j.freeradbiomed.2021.04.031)
- Richards, C. T., Meah, V. L., James, P. E., Rees, D. A. and Lord, R. N. 2021. HIIT’ing or MISS’ing the optimal management of polycystic ovary syndrome: a systematic review and meta-analysis of high- versus moderate-intensity exercise prescription. Frontiers in Physiology 12, article number: 715881. (10.3389/fphys.2021.715881)
- Merke, D. P. et al. 2021. Modified-release hydrocortisone in congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism 106(5), pp. e2063-e2077. (10.1210/clinem/dgab051)
- Thomas, M. et al. 2021. Insulin‐like growth factor‐1, growth hormone and disease outcomes in acromegaly: a population study. Clinical Endocrinology 95(1), pp. 143-152. (10.1111/cen.14468)
- Chambers, T. et al. 2021. Effects of thyroid status on regional brain volumes: a diagnostic and genetic imaging study in UK Biobank. Journal of Clinical Endocrinology and Metabolism 106(3), pp. 688-696. (10.1210/clinem/dgaa903)
- Lewis, R. D., Narayanaswamy, A. K., Farewell, D. and Rees, D. A. 2021. Complement activation in polycystic ovary syndrome occurs in the post-prandial and fasted state, and is influenced by obesity and insulin sensitivity. Clinical Endocrinology 94(1), pp. 74-84. (10.1111/cen.14322)
- Zhang, L. et al. 2020. Distinctive features of orbital adipose tissue (OAT) in Graves' orbitopathy. International Journal of Molecular Sciences 21(23), article number: 9145. (10.3390/ijms21239145)
- Pak, H. Y., Lansdown, A., Taylor, P., Rees, A. D., Davies, J. and Hayhurst, C. 2020. Acromegaly and the information gap: patient perceptions of the journey from primary to tertiary care. Endocrine Connections 9(10), pp. 971-977. (10.1530/EC-20-0335)
- Galloway, L., Ali, M., Lansdown, A., Taylor, P., Rees, A., Davies, J. S. and Hayhurst, C. 2020. The impact of endoscopic transsphenoidal pituitary adenoma surgery on endocrine function: a single-centre study. Acta Neurochirurgica 163(2), pp. 391-398. (10.1007/s00701-020-04609-x)
- Muller, I. et al. 2020. CATS II long-term anthropometric and metabolic effects of maternal sub-optimal thyroid function in offspring and mothers. Journal of Clinical Endocrinology and Metabolism 105(7), article number: dgaa129. (10.1210/clinem/dgaa129)
- Ellins, E., Shipley, M., Rees, D., Kemp, A., Deanfield, J., Brunner, E. and Halcox, J. 2020. Associations of depression-anxiety and dyslipidaemia with subclinical carotid arterial disease: Findings from the Whitehall II Study. European Journal of Preventive Cardiology 27(8), pp. 800-807. (10.1177/2047487319876230)
- Napier, C. et al. 2020. Residual adrenal function in autoimmune addison's disease - effect of dual therapy with rituximab and depot tetracosactide. Journal of Clinical Endocrinology and Metabolism 105(4), article number: Volume 105, Issue 4, April 2020,. (10.1210/clinem/dgz287)
- Hayhurst, C., Taylor, P., Lansdown, A., Palaniappan, N., Rees, D. and Davis, J. 2020. Current perspectives on recurrent pituitary adenoma: the role and timing of surgery vs adjuvant treatment. Clinical Endocrinology 92(2), pp. 89-97. (10.1111/cen.14127)
- Lansdown, A., Warbert, E., Sverrisdottir, Y., Wise, R. and Rees, D. 2019. Regional cerebral activation accompanies sympathoexcitation in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 104(9), pp. 3614-3623. (10.1210/jc.2019-00065)
- Wilson, N. et al. 2019. Role of hyaluronan in human adipogenesis: Evidence from in-vitro and in-vivo studies. International Journal of Molecular Sciences 20(11), article number: 2675. (10.3390/ijms20112675)
- Wadey, R. M., Connolly, K. D., Mathew, D., Walters, G., Rees, D. A. and James, P. E. 2019. Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells. Atherosclerosis 283, pp. 19-27. (10.1016/j.atherosclerosis.2019.01.013)
- Bhargava, R., Daughters, K. L. and Rees, D. A. 2019. Oxytocin therapy in hypopituitarism: challenges and opportunities. Clinical Endocrinology 90(2), pp. 257-264. (10.1111/cen.13909)
- Connolly, K. D., Wadey, R. M., Mathew, D., Johnson, E., Rees, D. A. and James, P. E. 2018. Evidence for adipocyte-derived extracellular vesicles in the human circulation. Endocrinology 159(9), pp. 3259-3267. (10.1210/en.2018-00266)
- Trainer, P. J. et al. 2018. A randomised, open-label, parallel group phase 2 study of antisense oligonucleotide therapy in acromegaly. European Journal of Endocrinology 179(2), pp. 97-108. (10.1530/EJE-18-0138)
- Berni, T., Morgan, C., Berni, E. and Rees, D. A. 2018. Polycystic ovary syndrome is associated with adverse mental health and neurodevelopmental outcomes. Journal of Clinical Endocrinology and Metabolism 103(6), pp. 2116-2125. (10.1530/endoabs.50.P353)
- Hales, C. et al. 2018. Controlled antenatal thyroid screening II: effect of treating maternal sub-optimal thyroid function on child cognition. Journal of Clinical Endocrinology and Metabolism 103(4), pp. 1583-1591. (10.1210/jc.2017-02378)
- Rees, D. A. 2018. Tips from the shop floor: Addisonian crisis - assessment and management. British Journal of Hospital Medicine 79(3), pp. 34-37. (10.12968/hmed.2018.79.3.C34)
- Witczak, J. K., Min, T., Prior, S. L., Stephens, J. W., James, P. E. and Rees, D. 2018. Bariatric surgery is accompanied by changes in extracellular vesicle-associated and plasma fatty acid binding protein 4. Obesity Surgery 28(3), pp. 767-774. (10.1007/s11695-017-2879-z)
- Burnley-Hall, N. et al. 2018. Dietary nitrate supplementation reduces circulating platelet-derived extracellular vesicles in coronary artery disease patients on clopidogrel therapy: a randomised, double-blind, placebo-controlled study. Thrombosis and Haemostasis 118(1), pp. 112-122. (10.1160/TH17-06-0394)
- Hubble, K., Daughters, K., Manstead, A., Rees, D., Thapar, A. and Van Goozen, S. 2017. Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear. Neuropsychologia 106, pp. 350-357. (10.1016/j.neuropsychologia.2017.10.019)
- Daughters, K., Manstead, A. S. R. and Rees, D. A. 2017. Hypopituitarism is associated with lower oxytocin concentrations and reduced empathic ability. Endocrine 57(1), pp. 166-174. (10.1007/s12020-017-1332-3)
- Taylor, P. N. et al. 2017. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study. Journal of Clinical Endocrinology and Metabolism 102(7), pp. 2508-2515. (10.1210/jc.2016-3605)
- Taylor, P. et al. 2017. Cerebral salt wasting following traumatic brain injury. Endocrinology, Diabetes & Metabolism Case Reports (10.1530/EDM-16-0142)
- Arlt, W. et al. 2017. Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism. JCI Insight 2(8), article number: e93136. (10.1172/jci.insight.93136)
- El-Farhan, N., Rees, D. A. and Evans, C. 2017. ANNALS EXPRESS: Measuring cortisol in serum, urine and saliva – are our assays good enough?. Annals of Clinical Biochemistry 54(3), pp. 308-322. (10.1177/0004563216687335)
- Draman, M. S., Stechman, M., Scott-Coombes, D., Dayan, C. M., Rees, D. A., Ludgate, M. and Zhang, L. 2017. The role of thyrotropin receptor activation in adipogenesis and modulation of fat phenotype. Frontiers in Endocrinology 8, article number: 83. (10.3389/fendo.2017.00083)
- Burnley-Hall, N., Willis, G., Davis, J., Rees, D. A. and James, P. E. 2017. Nitrite-derived nitric oxide reduces hypoxia-inducible factor 1α-mediated extracellular vesicle production by endothelial cells. Nitric Oxide: Biology and Chemistry 63, pp. 1-12. (10.1016/j.niox.2016.12.005)
- Ellins, E. A., Rees, D. A., Deanfield, J. E., Steptoe, A. and Halcox, J. P. 2017. Increased fibrinogen responses to psychophysiological stress predict future endothelial dysfunction implications for cardiovascular disease?. Brain, Behavior, and Immunity 60, pp. 233-239. (10.1016/j.bbi.2016.10.017)
- Hubble, K., Daughters, K., Manstead, A., Rees, D. A., Thapar, A. and Van Goozen, S. 2016. Oxytocin reduces face processing time but leaves recognition accuracy and eye-gaze unaffected. Journal of the International Neuropsychological Society 23(1), pp. 23-33. (10.1017/S1355617716000886)
- Drake, W. M. et al. 2016. A follow-up study of the prevalence of valvular heart abnormalities in hyperprolactinemic patients treated with cabergoline. Journal of Clinical Endocrinology & Metabolism 101(11), pp. 4189-4194. (10.1210/jc.2016-2224)
- Bondugulapati, L. and Rees, D. A. 2016. Inhaled corticosteroids and HPA axis suppression: how important is it and how should it be managed?. Clinical Endocrinology 85(2), pp. 165-169. (10.1111/cen.13073)
- Rees, D. A., Jenkins-Jones, S. and Morgan, C. L. 2016. Contemporary reproductive outcomes for patients with polycystic ovary syndrome: a retrospective observational study. Journal of Clinical Endocrinology & Metabolism 101(4), pp. 1664-1672. (10.1210/jc.2015-2682)
- Roy Chowdhury, S. et al. 2016. Diabetic retinopathy in newly diagnosed subjects with type 2 diabetes mellitus: contribution of β-Cell function. Journal of Clinical Endocrinology and Metabolism 101(2), pp. 572-580. (10.1210/jc.2015-2203)
- Taylor, P. et al. 2016. Paradoxical relationship between body mass index and thyroid hormone levels: a study using Mendelian randomization. Journal of Clinical Endocrinology & Metabolism 101(2), pp. 730-738. (10.1210/jc.2015-3505)
- Rees, D. A., Udiawar, M., Berlot, R., Jones, D. K. and O'Sullivan, M. J. 2016. White matter microstructure and cognitive function in young women with polycystic ovary syndrome. Journal of Clinical Endocrinology & Metabolism 101(1), pp. 314-323. (10.1210/jc.2015-2318)
- Daughters, K., Manstead, A. S. R., Hubble, K., Rees, D. A., Thapar, A. and Van Goozen, S. H. M. 2015. Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study. PLoS ONE 10(12), article number: e0145104. (10.1371/journal.pone.0145104)
- Connolly, K. D. et al. 2015. Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis. Journal of Extracellular Vesicles 4(s1), article number: 29159. (10.3402/jev.v4.29159)
- Grant, P. et al. 2015. Response to 'How we define hyponatremia'?. European Journal of Clinical Investigation 45(11), pp. 1218. (10.1111/eci.12515)
- Daniel, E. et al. 2015. Effectiveness of metyrapone in treating Cushing's Syndrome: a retrospective multicenter study in 195 patients. Journal of Clinical Endocrinology & Metabolism 100(11), pp. 4146. (10.1210/jc.2015-2616)
- Bondugulapati, L. N. R., Campbell, C., Chowdhury, S. R., Goetz, P., Davies, J. S., Rees, D. A. and Hayhurst, C. 2015. Use of day 1 early morning cortisol to predict the need for glucocorticoid replacement after pituitary surgery. British Journal of Neurosurgery 30(1), pp. 76-79. (10.3109/02688697.2015.1071325)
- Ellins, E. . A. et al. 2015. Validation of a new method for non-invasive assessment of vasomotor function. European Journal of Preventive Cardiology 23(6), pp. 577-583. (10.1177/2047487315597210)
- Margulescu, A. D., Rees, E., Coulson, R., Rees, D. A., Vinereanu, D. and Fraser, A. G. 2015. Do left atrial strain and strain rate reflect intrinsic atrial function, or are they determined by left ventricular function?. Kardiologia Polska 73(7), pp. 539-548. (10.5603/KP.a2015.0035)
- Grant, P. et al. 2015. The diagnosis and management of inpatient hyponatraemia and SIADH. European Journal of Clinical Investigation 45(8), pp. 888-894. (10.1111/eci.12465)
- Dénes, J. et al. 2015. Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a large patient cohort. Journal of Clinical Endocrinology & Metabolism 100(3), pp. E531. (10.1210/jc.2014-3399)
- Willis, G. R. et al. 2014. Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles. Human Reproduction 29(12), pp. 2756-2763. (10.1093/humrep/deu281)
- Willis, G. R., Udiawar, M., Evans, W. D., Blundell, H. L., James, P. E. and Rees, D. A. 2014. Detailed characterisation of circulatory nitric oxide and free radical indices-is there evidence for abnormal cardiovascular homeostasis in young women with polycystic ovary syndrome?. BJOG: An International Journal of Obstetrics and Gynaecology 121(13), pp. 1596-1603. (10.1111/1471-0528.12834)
- Connolly, K. D. et al. 2014. Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia. Journal of Lipid Research 55, pp. 2064-2072. (10.1194/jlr.M049726)
- Muller, I. and Rees, D. A. 2014. Melasma and endocrine disorders. Journal of Pigmentary Disorders S1, article number: 1. (10.4172/2376-0427.1000S1001)
- Gagliardi, L. et al. 2014. ARMC5 mutations are common in familial bilateral macronodular adrenal hyperplasia. Journal of Clinical Endocrinology & Metabolism 99(9), article number: E1784. (10.1210/jc.2014-1265)
- Rees, E. et al. 2014. Central arterial stiffness and diastolic dysfunction are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk. Human Reproduction 29(9), pp. 2041-2049. (10.1093/humrep/deu180)
- Han, T. S. et al. 2014. Relationship between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE). Journal of Clinical Endocrinology & Metabolism 99(8), pp. E1547-E1555. (10.1210/jc.2014-1486)
- Evans, C., El-Farhan, N., Ducroq, D. and Rees, D. A. 2014. Response to 'Determining the utility of the 60-min cortisol measurement in the short Synacthen test'. Clinical Endocrinology 80(5), pp. 766-767. (10.1111/cen.12272)
- Dodd, A. et al. 2014. The effect of serum matrix and gender on cortisol measurement by commonly used immunoassays. Annals of Clinical Biochemistry 51(3), pp. 379-385. (10.1177/0004563213514567)
- Ibrahim, R., Kalhan, A., Lammie, A., Kotonya, C., Nannapanenni, R. and Rees, D. R. 2014. Dense calcification in a GH-secreting pituitary macroadenoma. Endocrinology, Diabetes & Metabolism Case Reports, article number: EDM130079. (10.1530/EDM-13-0079)
- Hales, C. et al. 2014. The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol. BMC Endocrine Disorders 14(1), article number: 95. (10.1186/1472-6823-14-95)
- Owen, L. J. et al. 2013. Development of a rapid assay for the analysis of serum cortisol and its implementation into a routine service laboratory. Annals of Clinical Biochemistry 50(4), pp. 345-352. (10.1177/0004563212473448)
- Han, T. S. et al. 2013. Quality of life in adults with congenital adrenal hyperplasia relates to glucocorticoid treatment, adiposity and insulin resistance: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE). European Journal of Endocrinology 168(6), pp. 887-893. (10.1530/EJE-13-0128)
- El-Farhan, N. et al. 2013. Method-specific serum cortisol responses to the adrenocorticotrophin test: comparison of gas chromatography-mass spectrometry and five automated immunoassays. Clinical Endocrinology 78(5), pp. 673-680. (10.1111/cen.12039)
- Al-Sarireh, B., Haidermota, M., Verbeke, C., Rees, D. A., Yu, R. and Griffiths, A. 2013. Glucagon cell adenomatosis without glucagon receptor mutation [letter]. Pancreas 42(2), pp. 360-362. (10.1097/MPA.0b013e31825b6acd)
- Neale, S. M., Hocking, R., Biswas, M., Turkes, A., Rees, D., Rees, D. A. and Evans, C. 2013. Adult testosterone and calculated free testosterone reference ranges by tandem mass spectrometry. Annals of Clinical Biochemistry 50(2), pp. 159-161. (10.1258/acb.2012.012047)
- Han, T. S. et al. 2013. Glucocorticoid treatment regimen and health outcomes in adults with congenital adrenal hyperplasia. Clinical Endocrinology 78(2), pp. 197-203. (10.1111/cen.12045)
- Das, G., Eligar, V. S., Govindan, J. and Rees, D. A. 2013. Late presentation of hyperandrogenism in pregnancy: clinical features and differential diagnosis. Endocrinology, Diabetes & Metabolism Case Reports 10, article number: EDM130048. (10.1530/EDM-13-0048)
- Lansdown, A. and Rees, D. A. 2012. The sympathetic nervous system in polycystic ovary syndrome: a novel therapeutic target?. Clinical Endocrinology 77(6), pp. 791-801. (10.1111/cen.12003)
- Lunenfeld, B., Arver, S., Moncada, I., Rees, D. A. and Schulte, H. M. 2012. How to help the aging male? Current approaches to hypogonadism in primary care. The Aging Male 15(4), pp. 187-197. (10.3109/13685538.2012.729110)
- Morgan, C. L., Jenkins-Jones, S., Currie, C. J. and Rees, D. A. 2012. Evaluation of adverse outcome in young women with polycystic ovary syndrome versus matched, reference controls: a retrospective, observational study. Journal of Clinical Endocrinology & Metabolism 97(9), pp. 3251-3260. (10.1210/jc.2012-1690)
- Kalhan, A. et al. 2012. Adenosine A2A and A2B receptor expression in neuroendocrine tumours: potential targets for therapy. Purinergic Signalling 8(2), pp. 265-274. (10.1007/s11302-011-9280-5)
- Zhang, L., Grennan-Jones, F. A., Lane, C., Rees, D. A., Dayan, C. M. and Ludgate, M. E. 2012. Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy. Journal of Clinical Endocrinology & Metabolism 97(2), pp. 653-662. (10.1210/jc.2011-1299)
- Lansdown, A. J., Ludgate, M. E. and Rees, D. A. 2012. Metabolic syndrome: is the preadipocyte to blame? [Commentary]. Clinical Endocrinology 76(1), pp. 19-20. (10.1111/j.1365-2265.2011.04176.x)
- Biswas, M., Hampton, D., Newcombe, R. G. and Rees, D. A. 2012. Total and free testosterone concentrations are strongly influenced by age and central obesity in men with type 1 and type 2 diabetes but correlate weakly with symptoms of androgen deficiency and diabetes-related quality of life. Clinical Endocrinology 76(5), pp. 665-673. (10.1111/j.1365-2265.2011.04196.x)
- Lansdown, A. J. and Rees, D. A. 2011. Endocrine oncology in pregnancy. Best Practice & Research Clinical Endocrinology & Metabolism 25(6), pp. 911-926. (10.1016/j.beem.2011.06.011)
- Stephens, M. W., Ludgate, M. E. and Rees, D. A. 2011. Brown fat and obesity: the next big thing?. Clinical Endocrinology 74(6), pp. 661-670. (10.1111/j.1365-2265.2011.04018.x)
- Wiebke, A. et al. 2010. Health status of adults with congenital adrenal hyperplasia: A cohort study of 203 patients. Journal of Clinical Endocrinology & Metabolism 95(11), pp. 5110-5121. (10.1210/jc.2010-0917)
- Biswas, M., Hampton, D., Turkes, A., Newcombe, R. G. and Rees, D. A. 2010. Reduced total testosterone concentrations in young healthy South Asian men are partly explained by increased insulin resistance but not by altered adiposity. Clinical Endocrinology 73(4), pp. 457-462. (10.1111/j.1365-2265.2010.03824.x)
- Agarwal, N., Rice, S. P. L., Bolusani, H., Luzio, S. D., Dunseath, G. J., Ludgate, M. E. and Rees, D. A. 2010. Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: A randomized, placebo-controlled, crossover trial. Obstetrical & Gynecological Survey 65(6), pp. 381-382. (10.1097/OGX.0b013e3181e5a167)
- Rice, S. P. L., Zhang, L., Grennan-Jones, F. A., Agarwal, N., Lewis, M. D., Rees, D. A. and Ludgate, M. E. 2010. Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue. Molecular and Cellular Endocrinology 320(1-2), pp. 51-57. (10.1016/j.mce.2010.02.017)
- De Lloyd, A. C., Bursell, J. D. H., Gregory, J. W., Rees, D. A. and Ludgate, M. E. 2010. TSH receptor activation and body composition. Journal of Endocrinology 204(1), pp. 13-20. (10.1677/JOE-09-0262)
- Rees, D. A. and Dayan, C. M. 2010. Commentary: Testosterone and the metabolic syndrome: cause or consequence?. International Journal of Epidemiology 40(1), pp. 207-209. (10.1093/ije/dyq254)
- Agarwal, N., Rice, S. P. L., Bolusani, H., Luzio, S. D., Dunseath, G., Ludgate, M. and Rees, D. A. 2010. Metformin Reduces Arterial Stiffness and Improves Endothelial Function in Young Women with Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled, Crossover Trial. Journal of Clinical Endocrinology & Metabolism 95(2), pp. 722-730. (10.1210/jc.2009-1985)
- Krone, N. et al. 2009. Current management, morbidity and genotypephenotype correlation in adults with congenital adrenal hyperplasia – analysis of the United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE) cohort [Abstract]. Hormone Research 72(S3), pp. 41-41. (10.1159/000239668)
- Rice, S. P. L., Agarwal, N., Bolusani, H., Newcombe, R. G., Scanlon, M. F., Ludgate, M. E. and Rees, D. A. 2009. Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: A randomized crossover trial. Journal of Clinical Endocrinology & Metabolism 94(6), pp. 1966-1972. (10.1210/jc.2008-2636)
- Rees, D. A., Giles, P. J., Lewis, M. D. and Ham, J. 2009. Adenosine regulates thrombomodulin and endothelial protein C receptor expression in folliculostellate cells of the pituitary gland. Purinergic Signalling 6(1), pp. 19-29. (10.1007/s11302-009-9172-0)
- Watson, S., Blundell, H. L., Evans, W., Griffiths, H., Newcombe, R. G. and Rees, D. A. 2009. Can abdominal bioelectrical impedance refine the determination of visceral fat from waist circumference?. Physiological Measurement 30(7), pp. N53-N58. (10.1088/0967-3334/30/7/N01)
- Colao, A. et al. 2009. Octreotide LARvs.surgery in newly diagnosed patients with acromegaly: a randomized, open-label, multicentre study. Clinical Endocrinology 70(5), pp. 757-768. (10.1111/j.1365-2265.2008.03441.x)
- Ham, J. and Rees, D. A. 2008. The adenosine a2b receptor: its role in inflammation. Endocrine‚ Metabolic & Immune Disorders - Drug Targets 8(4), pp. 244-254.
- Millar, D. S. et al. 2008. Growth hormone (GH1) gene variation and the growth hormone receptor (GHR) exon 3 deletion polymorphism in a West-African population. Molecular and Cellular Endocrinology 296(1-2), pp. 18-25. (10.1016/j.mce.2008.09.023)
- Cozma, I., Zhang, L., Uddin, J., Lane, C., Rees, D. A. and Ludgate, M. E. 2007. Modulation of expression of somatostatin receptor subtypes in Graves' opthalmopathy orbits : relevance to novel analogues. American Journal of Physiology. Endocrinology and Metabolism (10.1152/ajpendo.00177.2007)
- Lewis, B. M. et al. 2006. Adenosine stimulates connexin 43 expression and gap junctional communication in pituitary folliculostellate cells. The FASEB Journal 20(14), pp. 2585-2587. (10.1096/fj.06-6121fje)
- Rees, D. A., Lewis, B. M., Lewis, M. D., Francis, K., Scanlon, M. F. and Ham, J. 2003. Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK. British Journal of Pharmacology 140(4), pp. 764-72. (10.1038/sj.bjp.0705488)
- De, P. et al. 2003. Transsphenoidal surgery for acromegaly in Wales: results based on stringent criteria of remission. Journal of Clinical Endocrinology & Metabolism 88(8), pp. 3567-72. (10.1210/jc.2002-021822)
- Rees, D. A., Gayle, C., Gaillard, R. C. and Fear, S. 2002. Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults. Journal of Clinical Endocrinology & Metabolism 87(6), pp. 2725-33. (10.1210/jc.87.6.2725)
- Rees, D. A., Lewis, M. D., Lewis, B. M., Smith, P. J., Scanlon, M. F. and Ham, J. 2002. Adenosine-regulated cell proliferation in pituitary folliculostellate and endocrine cells: differential roles for the A(1) and A(2B) adenosine receptors. Endocrinology 143(6), pp. 2427-2436. (10.1210/en.143.6.2427)
- Clarke, A. J., Bradley, D. M., Gillespie, K., Rees, D. A., Holland, A. and Thomas, N. S. T. 1992. Fragile X mental retardation and the iduronate sulphatase locus: testing laird's model of fra(X) inheritance. American Journal of Medical Genetics 43(1-2), pp. 299-306. (10.1002/ajmg.1320430146)
Book sections
- Rees, S. and Rees, D. A. 2026. Prolactinomas: Clinical manifestations and therapy. In: Huhtaniemi, I. ed. Encyclopedia of Endocrine Diseases, 3rd Edition. Elsevier
- Scholz, A. and Rees, D. A. 2018. Prolactinomas: Clinical manifestations and therapy. In: Huhtaniemi, I. and Martini, L. eds. Encyclopedia of Endocrine Diseases (Second Edition). Elsevier, pp. 319-324., (10.1016/B978-0-12-801238-3.65181-4)
- Rice, S. J. and Rees, D. A. 2011. DHEA and vascular function. In: Watson, R. R. ed. DHEA in Human Health and Aging. Boca Raton, Fl: CRC Press, pp. 375-388.
Books
- Scanlon, M. F. and Rees, D. A. eds. 2008. Specialist training in endocrinology. Edinburgh: Mosby/Elsevier,.
Research
Current projects
My current studies use advanced MRI to understand the impact of the hormonal environment in early life on cognition and neurodevelopment. My group has shown altered white matter microstructure and cognitive ability in young women with Polycystic Ovary Syndrome (PCOS), building on previous epidemiological and basic science studies which have established the long-term metabolic and cardiovascular outcomes in this patient population. Our long-term follow-up study of children born to mothers in the Controlled Antenatal Thyroid Screening (CATS) trial will enable us to assess the effects of thyroid hormone exposure in pregnancy on neurodevelopment, using the state-of-the-art MRI facilities in the Cardiff University Brain Research Imaging Centre (CUBRIC).
Epidemiological and genetic analyses in large datasets, including CPRD and UK Biobank, are examining cardiovascular morbidity in women with PCOS, and effects of maternal thyroid status on brain structure and educational outcomes. Studies in Resistance to Thyroid Hormone Beta include a databank study which will delineate long-term health outcomes and clinical trials of novel therapies.
The James Lind Alliance Priority Setting Partnership in PCOS will establish the top 10 research priorities for this disorder.
Funding
2024-2026 “A Priority Setting Partnership to identify the top 10 research priorities for people living with Polycystic Ovary Syndrome and the practitioners providing their health care”; Type: Project grant; Principal Investigator: Rees DA; Co-investigators: Channon S, Morman R, Andrews C. Agency: The Waterloo Foundation; Budget: £64,160
2021-2022 “Which patients taking glucocorticoid therapy are at risk of adrenal crisis and major adverse hospital outcomes? Utilisation of real-World electronic health records to inform a risk-stratified educational approach.”; Type: Clinical Research Fellowship; Research Fellow: Williams D; Supervisor: Rees DA; Agency: Royal College of Physicians; Budget: £30,000
2021-2022 “Steroid Safety Solutions: Development and Impact of Pharmacy Steroid Advice Service on Patient Safety & Professional Practice”; Type: Project grant; Principal Investigator: James L; Co-investigators: Rees DA, James D; Agency: Welsh Assembly Government (Pharmacy: delivering a Healthier Wales); Budget: £18,477
2021-2022 “Determining the role of oestrogen in vascular health and protection across the lifespan”; Type: Project grant; Research Fellow: Steventon J; Supervisors: Rees DA, Murphy K; Agency: Sir Geraint Evans Cardiovascular Research Fund; Budget: £45,298.
2019-2021 “The role of oestrogen in vascular ageing”; Type: ISSF Fellowship; Research Fellow: Steventon J; Supervisors: Rees DA, Murphy K; Agency: The Wellcome Trust; Budget: £84,678.
2019-2021 "Effects of high-intensity interval training versus moderate-intensity steady-state training on mental health, cognitive and cardiometabolic outcomes in young women with Polycystic Ovary Syndrome: a pilot randomised, controlled trial"; Type: Project Grant; Principal Investigator: Rees DA; Agency: The Waterloo Foundation; Budget: £73,209.
2018-2020 "Effects of gestational thyroid hormone exposure on ADHD risk: insights into neurodevelopment using advanced MRI"; Type: Clinical Research Fellowship (to Scholz); Principal Investigator: Rees DA; Agency: Royal College of Physicians (Lewis Thomas Gibbon Jenkins of Briton Ferry Fellowship); Budget: £30,000
2018-2020 "Treatment of suboptimal maternal thyroid function as a window to mechanisms of childhood brain development and function"; Type: Project Grant; Principal Investigator: Rees DA; Agency: The Waterloo Foundation; Budget: £59,531
2015-2017 “Cell-derived microparticles as mediators of obesity-induce vascular disease”; Type: Clinical Research Fellowship (to Witczak); Principal Investigator: Rees DA; Co-Investigators: James PJ, Witczak J; Agency: Royal College of Physicians; Budget: £120,417
2015-2018 “Extracellular vesicle transport in the circulation – a missing link between adipocytes and accelerated vascular dysfunction”;Type: Project Grant; Principal Investigator: James PJ; Co-Investigators: Rees DA, Ludgate M, Lewis T, Clayton A, O’Donnell V. Agency: British Heart Foundation; Budget: £226,891
2014-2017“Measurement of pathologically relevant microvesicle populations in obesity-driven cardiovascular disease”;Type: PhD studentship; Principal Investigator:James PJ; Co-Investigator: Rees DA; Agency: Cardiff University College of Biomedical & Life Sciences; Budget: £75,000
2014-2017“Can we prevent generation of pro-thrombotic and pro-coagulant extracellular vesicle populations in blood via a simple dietary intervention?” Type: PhD studentship; Principal Investigator: Rees DA; Co-Investigator: James PJ; Agency: National Institute for Social Care and Health Research; Budget: £66,926
2014-2015“Diabetes Research Network Statistician” Type: Grant. Principal Investigator: Rees DA; Co-Investigator: Dayan C; Agency: National Institute for Social Care and Health Research; Budget: £53,344
2012-2015 “The interface between adipose tissue-derived microvesicles and vascular endothelium in polycystic ovary syndrome”;Type: PhD studentship; Principal Investigator: Rees DA; Co-Investigator: James PJ; Agency: Cardiff University Ewen Maclean Bequest Scholarship; Budget: £66,402
2012-2013 “Anthropometric and metabolic correlates of sympathetic nervous system activity in young women with PCOS: a functional MRI study”; Type: Early Career Award; Principal Investigator: Rees DA; Co-Investigator: Lansdown A; Agency: Society for Endocrinology; Budget: £10,000
2012-2013 “A pilot study to determine whether complement activation modulates lipid metabolism in health and disease” Type: Wellcome Trust ISSF Fellowship; Principal Investigator: Lewis R; Co-Investigators: Rees DA, Morgan BP; Agency: Wellcome Trust; Budget: £44,130
2011-2014 “Influence of regional adiposity on endothelial effects of LDL cholesterol in Polycystic Ovary Syndrome”; Type: PhD studentship; Principal Investigator: James PJ; Co-Investigator: Rees DA; Agency: Cardiff University John Nixon Bequest Scholarship; Budget: £68,412
Impact
I have established a large cohort of young patients with Polycystic Ovary Syndrome (PCOS), using this as a common (5-10% premenopausal women) clinical model of metabolically unhealthy obesity and early life vascular risk.
I employed a series of non-invasive cardiovascular methodologies to carefully phenotype the cohort and demonstrate the importance of insulin resistance and central obesity as independent cardiovascular risk markers. My group undertook a randomised, double blind, placebo-controlled trial to show that metformin improves vascular function in women with PCOS. I have also exploited the power of the Clinical Practice Research Database to define the natural history of PCOS, confirming an increased risk of type 2 diabetes, adverse pregnancy outcomes, adverse mental health outcomes and cardiovascular events, in addition to a significant impact on the UK healthcare economy.
I also hold a strong interest in steroid disorders; in adrenal disease, I led two clinical trials which re-defined method-specific reference limits to the synacthen test, demonstrated the validity of salivary responses, and explored the effects of DHEA on vascular function. I have undertaken a number of studies in Congenital Adrenal Hyperplasia which have helped define the health outcomes and contributed to the development of new therapies.
Follow-up of the Controlled Antenatal Thyroid Screening (CATS) study cohort has clarified the importance of avoiding over-replacement with levothyroxine in pregnancy, whilst also demonstrating an effect on adolescent brain microstructure.
I disseminate my work regularly via engagement with patient groups, the Society For Endocrinology and the media (BBC, S4C, Radio Cymru).
Teaching
I contribute to the delivery, design and assessment of the undergraduate medical curriculum from years 1 through to 5, and play an active role in postgraduate medical teaching at local and national levels.
Undergraduate
I deliver ward-based and outpatient teaching to year 3-5 students, and supervise student selected component (SSC) projects in years 3 and 4. Following the introduction of the C21 undergraduate curriculum in Cardiff, I completed the Medical Education Orientation Programme (MEOP), became a tutor on ‘reproductive hormones’ for the Platform in Clinical Science in phase 1a (year 1) and case-based writing lead (‘Diabetes in an older person’) for phase 1b (year 2). I am an academic mentor for medical undergraduates and have been an examiner at medical finals for the last 15 years. I regularly host students on the Erasmus exchange programme. I was awarded a Certificate of Teaching Excellence from Cardiff and Vale University Health Board in 2010. I deliver an annual lecture to dental undergraduates on steroid disorders.
On a UK level, I helped develop a set of National Standards, adopted jointly by the Society for Endocrinology, the Association of British Clinical Diabetologists (ABCD) and Diabetes UK, for undergraduate education in Endocrinology and Diabetes, benchmarked against Tomorrow’s Doctors (2012). In 2015 I edited and authored Clinical Endocrinology and Diabetes at a Glance, a leading UK undergraduate text series in clinical medicine.
Postgraduate
As the academic lead on the Specialist Training Committee for Endocrinology and Diabetes in Wales, I established a neuroendocrine teaching programme for specialist registrars. Supported by a grant from the Society for Endocrinology, I introduced a poster presentation session and developed undergraduate and postgraduate prizes at the annual Welsh Endocrine and Diabetes Society (WEDS) meeting. Subsequently, as chair of WEDS, I organised the first Society for Endocrinology Regional Clinical Cases meeting to be held in Wales. I was selected as a Convenor for the Society for Endocrinology Clinical Update course (2012-2018), where I designed and delivered teaching on neuroendocrine tumours, inherited endocrine neoplasia, hyponatraemia and hypoglycaemia to over 200 Specialist Registrars and Consultants annually. I was a Royal College of Physicians Specialty Certificate Examination board member for Endocrinology and Diabetes (2020-2023) and am currently co-lead for the Pituitary and Adrenal sections of the American Endocrine Society's annual ESAP programme.
In recognition of my commitment to undergraduate and postgraduate teaching, I was elected to the Academy of Medical Educators.
Biography
Education and qualifications
- 2013: MAcadMEd
- 2010: FRCP, London
- 2002: PhD (Neuroendocrinology) University of Wales College of Medicine, Cardiff, UK
- 1996: MRCP, London
- 1993: MB, BCh (Hons), University of Wales College of Medicine, Cardiff, UK
Career overview
- 2019 - present: Professor of Endocrinology and Honorary Consultant Endocrinologist, Neuroscience and Mental Health Research Institute, Cardiff University
- 2015 - 2019: Reader in Neuroendocrinology and Honorary Consultant Endocrinologist, Neuroscience and Mental Health Research Institute, Cardiff University
- 2006 - 2015: Senior Lecturer and Honorary Consultant Endocrinologist, Cardiff University
- 2003 – 2006: Clinical Lecturer in Endocrinology, Cardiff University
- 2001 – 2003: Specialist Registrar in Endocrinology, South Wales
- 1998 – 2001: Society for Endocrinology Clinical Endocrinology Trust Research Fellow, University of Wales College of Medicine, Cardiff
- 1997 – 1998: Wellcome Trust Clinical Training Fellow, University of Wales College of Medicine, Cardiff
- 1996 – 1997: Registrar in General Medicine, Royal Gwent Hospital, Newport
- 1994 – 1996: Senior House Officer in Medicine, South Wales
- 1993 – 1994: House Officer in Medicine and Surgery, University Hospital of Wales and Llandough Hospital
Honours and awards
- 2005: Novartis European Young Investigator Award. Characterisation of the role of extracellular signal-regulated kinases in growth hormone action: insights from novel human growth hormone 1 (GH1) gene mutations.
- 2015 – 2017: Associate Editor, Clinical Endocrinology
- 2017 - 2024: Senior Editor, Clinical Endocrinology
- 2024 - 2027: General Secretary, Society for Endocrinology
Professional memberships
- Fellow of the Royal College of Physicians
- Association of Physicians of Great Britain and Ireland
- Association of Clinical Professors of Medicine
- Society for Endocrinology (UK)
- The Endocrine Society (USA)
- European Society of Endocrinology
- European Neuroendocrine Tumour Society
- UK and Ireland Neuroendocrine Tumour Society
- British Medical Association
- Society of Physicians in Wales
- Welsh Endocrine and Diabetes Society
Committees and reviewing
- 2011 - 2015: Member of the School of Medicine Higher Degree committee
- 2007 – 2010: Member of the Research Governance group
External committees
- 2020 - present: Cardiff co-Lead Welsh Clinical Academic Training scheme
- 2018 - present: Society for Endocrinology Council
- 2016 – present: National Institute for Health Research Metabolic and Endocrine Specialty Group
- 2015 – 2018: Society for Endocrinology Finance committee
- 2018 – 2019: DRU Cymru External Advisory Board
- 2014 – 2024: Chair, Welsh Endocrine and Diabetes Society
- 2010 – present: Research and Development Lead, Medicine Board, Cardiff & Vale University Health Board
- 2015 – 2018: Executive group member of the Diabetes Research Unit Cymru
- 2012 – 2018: Faculty member, Society for Endocrinology Clinical Update meeting
- 2014 – 2016: Editorial Board, Scientific Reports
- 2012 – 2016: Member of the Society for Endocrinology Clinical committee
- 2011 – 2016: Committee member of the UK Acromegaly study group
- 2009 – 2013: Editorial Board, Clinical Endocrinology
- 2007 – 2014: Member of the Specialist Training Committee, Endocrinology and Diabetes, Wales Deanery
- 2005 – 2014: Committee member of the Congenital Adrenal Hyperplasia Adult Study Executive
Contact Details
Research themes
Specialisms
- Endocrinology