![Simon Scofield](https://profiles-cardiff.imgix.net/attachments/1214?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Simon Scofield
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Simon Scofield
Uwch Ddarlithydd
Biowyddorau Moleciwlaidd
Trosolwg
Mae ymchwil yn fy labordy yn canolbwyntio ar reoleiddio moleciwlaidd datblygiad planhigion a pheirianneg metaboledd planhigion.
Rydym yn astudio rheoleiddio trawsgrifio pluripotency a gwahaniaethu mewn bôn-gelloedd planhigion, gan ddefnyddio'r rhywogaeth model Arabidopsis thaliana yn bennaf. Rydym yn defnyddio mynegiant genynnau inducible a systemau ymyrraeth RNA, ynghyd â golygu genom cyfryngol CRISPR-CAS9, i astudio swyddogaeth ffactor trawsgrifio yn y meristem apical egin. Defnyddir dulliau dadansoddi trawsgrifio a rhwydweithio genynnau i nodi targedau ffactor trawsgrifio ac integreiddio eu swyddogaeth o fewn fframwaith ehangach rheoleiddwyr datblygiadol.
Rydym hefyd yn astudio biosynthesis metabolitau eilaidd yn y teulu mintys, peirianneg planhigion i gynhyrchu gwahanol gyfansoddion terpenoid trwy addasu genetig, ac ar synthesis lipidau mewn cnydau hadau olew. Rydym yn defnyddio trawsgrifiad a biocemeg ddadansoddol i ddeall a pheirianneg cynhyrchu'r metabolitau hyn mewn gwahanol rywogaethau planhigion.
Rolau
- Arweinydd Blwyddyn Hyfforddiant Proffesiynol
- Arweinydd academaidd - Hwb Technoleg Twf Planhigion
- Arweinydd Modiwl ar gyfer BI2234 Bioleg Moleciwlaidd y Genyn
Oes gennych chi ddiddordeb mewn ymuno â'm labordy fel myfyriwr ôl-raddedig hunan-ariannu neu ôl-ddoethurwriaeth/cymrawd? Cysylltwch â mi drwy e-bost.
Cyhoeddiad
2026
- Randerson, P. et al. 2026. Evaluating repellence properties of a catnip essential oil-based mosquito repellent: From laboratory studies to human field trials in eastern Uganda. Presented at: XXVI International Science Conference Kyiv, Ukraine 25-26 June 2026. Proceedings of the International Scientific and Practical Conference "Ecology. Man. Society". , pp.90-101. (10.20535/EHS2710-3315.2026.363930)
- Carpenter, J. H. et al. 2026. Big data approaches to understanding gene regulatory networks in the shoot apical meristem and de novo shoot regeneration. Frontiers in Plant Science 17 1837132. (10.3389/fpls.2026.1837132)
- Batume, C. et al., 2026. Evaluating repellence properties of a catnip essential oil-based mosquito repellent using the human landing catch method in Eastern Uganda. Scientific Reports 16 13272. (10.1038/s41598-026-42618-5)
- Liao, P. et al., 2026. Lipid regulation in Brassica napus: spatiotemporal studies to enhance our understanding. Frontiers in Plant Science 17 1813997. (10.3389/fpls.2026.1813997)
2025
- Baldwin, A. et al. 2025. The H3K27me3 histone mark correlates with repression of colour and aroma development post-harvest in strawberry fruit. Journal of Experimental Botany 76 (9), pp.2487-2499. (10.1093/jxb/erae464)
- Lechon, T. et al. 2025. Regulation of meristem and hormone function revealed through analysis of directly-regulated SHOOT MERISTEMLESS target genes. Scientific Reports 15 (1) 240. (10.1038/s41598-024-83985-1)
2024
- Weselake, R. J. et al., 2024. Increasing oil content in Brassica oilseed species. Progress in Lipid Research 96 101306. (10.1016/j.plipres.2024.101306)
- Coates, R. J. , Scofield, S. and Young, M. T. 2024. Incorporation of regulatory DNA elements within a viral vector improves recombinant protein expression in plants. Scientific Reports 14 (1) 28865. (10.1038/s41598-024-80444-9)
- Batume, C. et al., 2024. Evaluating repellence properties of catnip essential oil against the mosquito species Aedes aegypti using a Y-tube olfactometer. Scientific Reports 14 2269. (10.1038/s41598-024-52715-y)
2022
- Coates, R. J. , Young, M. T. and Scofield, S. 2022. Optimising expression and extraction of recombinant proteins in plants. Frontiers in Plant Science 13 1074531. (10.3389/fpls.2022.1074531)
- Fuchs, L. K. et al. 2022. Genetic manipulation of biosynthetic pathways in mint. Frontiers in Plant Science 13 928178. (10.3389/fpls.2022.928178)
- Liao, P. et al., 2022. Transgenic manipulation of triacylglycerol biosynthetic enzymes in B. napus alters lipid-associated gene expression and lipid metabolism. Scientific Reports 12 (1) 3352. (10.1038/s41598-022-07387-x)
2019
- Liao, P. et al., 2019. Comparative transcriptomics analysis of Brassica napus L. during seed maturation reveals dynamic changes in gene expression between embryos and seed coats and distinct expression profiles of Acyl-CoA-binding proteins for lipid accumulation. Plant and Cell Physiology 60 (12), pp.2812-2825. (10.1093/pcp/pcz169)
2018
- Scofield, S. et al. 2018. Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network. Development 145 (9) dev157081. (10.1242/dev.157081)
2017
- Perry, I. et al. 2017. Production of 3D printed scale models from microscope volume datasets for use in STEM education. EMS Engineering Science Journal 1 (1) 002.
2015
- Galletti, R. et al., 2015. DEFECTIVE KERNEL 1 promotes and maintains plant epidermal differentiation. Development 142 (11), pp.1978-1983. (10.1242/dev.122325)
2014
- Scofield, S. , Jones, A. and Murray, J. A. H. 2014. The plant cell cycle in context. Journal of Experimental Botany 65 (10), pp.2557-2562. (10.1093/jxb/eru188)
- Scofield, S. , Dewitte, W. and Murray, J. A. H. 2014. STM sustains stem cell function in the Arabidopsis shoot apical meristem and controls KNOX gene expression independently of the transcriptional repressor AS1. Plant Signaling and Behavior 9 (6) e28934. (10.4161/psb.28934)
2013
- Scofield, S. et al. 2013. The Arabidopsis homeobox gene SHOOT MERISTEMLESS has cellular and meristem-organisational roles with differential requirements for cytokinin and CYCD3 activity. The Plant Journal 75 (1), pp.53-66. (10.1111/tpj.12198)
2009
- Nieuwland, J. et al. 2009. The D-type cyclin CYCD4;1 modulates lateral root density in Arabidopsis by affecting the basal meristem region. Proceedings of the National Academy of Sciences of the United States of America 106 (52), pp.22528-22533. (10.1073/pnas.0906354106)
- De Jager, S. M. et al., 2009. Dissecting regulatory pathways of G1/S control in Arabidopsis: common and distinct targets of CYCD3;1 E2Fa and E2Fc. Plant Molecular Biology 71 (4-5), pp.345-365. (10.1007/s11103-009-9527-5)
- Nieuwland, J. , Scofield, S. and Murray, J. A. H. 2009. Control of division and differentiation of plant stem cells and their derivatives. Seminars in Cell and Developmental Biology 20 (9), pp.1134-1142. (10.1016/j.semcdb.2009.09.011)
2008
- Scofield, S. , Dewitte, W. and Murray, J. A. H. 2008. A model for Arabidopsis class-1 KNOX gene function. Plant Signaling and Behavior 3 (4), pp.257-259. (10.1111/j.1365-313X.2007.03095.x)
2007
- Dewitte, W. et al. 2007. Arabidopsis CYCD3 D-type cyclins link cell proliferation and endocycles and are rate-limiting for cytokinin responses. Proceedings of the National Academy of Sciences of the United States of America 104 (36), pp.14537-14542. (10.1073/pnas.0704166104)
- Scofield, S. , Dewitte, W. and Murray, J. A. H. 2007. The KNOX gene SHOOT MERISTEMLESS is required for the development of reproductive meristematic tissues in Arabidopsis. The Plant Journal 50 (5), pp.767-781. (10.1111/j.1365-313X.2007.03095.x)
2006
- Scofield, S. and Murray, J. A. H. 2006. KNOX gene function in plant stem cell niches. Plant Molecular Biology 60 (6), pp.929-946. (10.1007/s11103-005-4478-y)
- Scofield, S. and Murray, J. A. H. 2006. The evolving concept of the Meristem. Plant Molecular Biology 60 (6), pp.V-VII. (10.1007/s11103-006-0061-4)
2005
- Jager, S. et al., 2005. The developmental context of cell-cycle control in plants. Seminars in Cell and Developmental Biology 16 (3), pp.385-396. (10.1016/j.semcdb.2005.02.004)
- Masubelele, N. H. et al., 2005. D-type cyclins activate division in the root apex to promote seed germination in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America 102 (43), pp.15694-15699. (10.1073/pnas.0507581102)
2002
- Dewitte, W. et al. 2002. Altered cell cycle distribution, hyperplasia, and inhibited differentiation in Arabidopsis caused by the D-type cyclin CYCD3. The Plant Cell 15 (1), pp.79-92. (10.1105/tpc.004838)
Cynadleddau
- Randerson, P. et al. 2026. Evaluating repellence properties of a catnip essential oil-based mosquito repellent: From laboratory studies to human field trials in eastern Uganda. Presented at: XXVI International Science Conference Kyiv, Ukraine 25-26 June 2026. Proceedings of the International Scientific and Practical Conference "Ecology. Man. Society". , pp.90-101. (10.20535/EHS2710-3315.2026.363930)
Erthyglau
- Carpenter, J. H. et al. 2026. Big data approaches to understanding gene regulatory networks in the shoot apical meristem and de novo shoot regeneration. Frontiers in Plant Science 17 1837132. (10.3389/fpls.2026.1837132)
- Batume, C. et al., 2026. Evaluating repellence properties of a catnip essential oil-based mosquito repellent using the human landing catch method in Eastern Uganda. Scientific Reports 16 13272. (10.1038/s41598-026-42618-5)
- Liao, P. et al., 2026. Lipid regulation in Brassica napus: spatiotemporal studies to enhance our understanding. Frontiers in Plant Science 17 1813997. (10.3389/fpls.2026.1813997)
- Baldwin, A. et al. 2025. The H3K27me3 histone mark correlates with repression of colour and aroma development post-harvest in strawberry fruit. Journal of Experimental Botany 76 (9), pp.2487-2499. (10.1093/jxb/erae464)
- Lechon, T. et al. 2025. Regulation of meristem and hormone function revealed through analysis of directly-regulated SHOOT MERISTEMLESS target genes. Scientific Reports 15 (1) 240. (10.1038/s41598-024-83985-1)
- Weselake, R. J. et al., 2024. Increasing oil content in Brassica oilseed species. Progress in Lipid Research 96 101306. (10.1016/j.plipres.2024.101306)
- Coates, R. J. , Scofield, S. and Young, M. T. 2024. Incorporation of regulatory DNA elements within a viral vector improves recombinant protein expression in plants. Scientific Reports 14 (1) 28865. (10.1038/s41598-024-80444-9)
- Batume, C. et al., 2024. Evaluating repellence properties of catnip essential oil against the mosquito species Aedes aegypti using a Y-tube olfactometer. Scientific Reports 14 2269. (10.1038/s41598-024-52715-y)
- Coates, R. J. , Young, M. T. and Scofield, S. 2022. Optimising expression and extraction of recombinant proteins in plants. Frontiers in Plant Science 13 1074531. (10.3389/fpls.2022.1074531)
- Fuchs, L. K. et al. 2022. Genetic manipulation of biosynthetic pathways in mint. Frontiers in Plant Science 13 928178. (10.3389/fpls.2022.928178)
- Liao, P. et al., 2022. Transgenic manipulation of triacylglycerol biosynthetic enzymes in B. napus alters lipid-associated gene expression and lipid metabolism. Scientific Reports 12 (1) 3352. (10.1038/s41598-022-07387-x)
- Liao, P. et al., 2019. Comparative transcriptomics analysis of Brassica napus L. during seed maturation reveals dynamic changes in gene expression between embryos and seed coats and distinct expression profiles of Acyl-CoA-binding proteins for lipid accumulation. Plant and Cell Physiology 60 (12), pp.2812-2825. (10.1093/pcp/pcz169)
- Scofield, S. et al. 2018. Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network. Development 145 (9) dev157081. (10.1242/dev.157081)
- Perry, I. et al. 2017. Production of 3D printed scale models from microscope volume datasets for use in STEM education. EMS Engineering Science Journal 1 (1) 002.
- Galletti, R. et al., 2015. DEFECTIVE KERNEL 1 promotes and maintains plant epidermal differentiation. Development 142 (11), pp.1978-1983. (10.1242/dev.122325)
- Scofield, S. , Jones, A. and Murray, J. A. H. 2014. The plant cell cycle in context. Journal of Experimental Botany 65 (10), pp.2557-2562. (10.1093/jxb/eru188)
- Scofield, S. , Dewitte, W. and Murray, J. A. H. 2014. STM sustains stem cell function in the Arabidopsis shoot apical meristem and controls KNOX gene expression independently of the transcriptional repressor AS1. Plant Signaling and Behavior 9 (6) e28934. (10.4161/psb.28934)
- Scofield, S. et al. 2013. The Arabidopsis homeobox gene SHOOT MERISTEMLESS has cellular and meristem-organisational roles with differential requirements for cytokinin and CYCD3 activity. The Plant Journal 75 (1), pp.53-66. (10.1111/tpj.12198)
- Nieuwland, J. et al. 2009. The D-type cyclin CYCD4;1 modulates lateral root density in Arabidopsis by affecting the basal meristem region. Proceedings of the National Academy of Sciences of the United States of America 106 (52), pp.22528-22533. (10.1073/pnas.0906354106)
- De Jager, S. M. et al., 2009. Dissecting regulatory pathways of G1/S control in Arabidopsis: common and distinct targets of CYCD3;1 E2Fa and E2Fc. Plant Molecular Biology 71 (4-5), pp.345-365. (10.1007/s11103-009-9527-5)
- Nieuwland, J. , Scofield, S. and Murray, J. A. H. 2009. Control of division and differentiation of plant stem cells and their derivatives. Seminars in Cell and Developmental Biology 20 (9), pp.1134-1142. (10.1016/j.semcdb.2009.09.011)
- Scofield, S. , Dewitte, W. and Murray, J. A. H. 2008. A model for Arabidopsis class-1 KNOX gene function. Plant Signaling and Behavior 3 (4), pp.257-259. (10.1111/j.1365-313X.2007.03095.x)
- Dewitte, W. et al. 2007. Arabidopsis CYCD3 D-type cyclins link cell proliferation and endocycles and are rate-limiting for cytokinin responses. Proceedings of the National Academy of Sciences of the United States of America 104 (36), pp.14537-14542. (10.1073/pnas.0704166104)
- Scofield, S. , Dewitte, W. and Murray, J. A. H. 2007. The KNOX gene SHOOT MERISTEMLESS is required for the development of reproductive meristematic tissues in Arabidopsis. The Plant Journal 50 (5), pp.767-781. (10.1111/j.1365-313X.2007.03095.x)
- Scofield, S. and Murray, J. A. H. 2006. KNOX gene function in plant stem cell niches. Plant Molecular Biology 60 (6), pp.929-946. (10.1007/s11103-005-4478-y)
- Scofield, S. and Murray, J. A. H. 2006. The evolving concept of the Meristem. Plant Molecular Biology 60 (6), pp.V-VII. (10.1007/s11103-006-0061-4)
- Jager, S. et al., 2005. The developmental context of cell-cycle control in plants. Seminars in Cell and Developmental Biology 16 (3), pp.385-396. (10.1016/j.semcdb.2005.02.004)
- Masubelele, N. H. et al., 2005. D-type cyclins activate division in the root apex to promote seed germination in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America 102 (43), pp.15694-15699. (10.1073/pnas.0507581102)
- Dewitte, W. et al. 2002. Altered cell cycle distribution, hyperplasia, and inhibited differentiation in Arabidopsis caused by the D-type cyclin CYCD3. The Plant Cell 15 (1), pp.79-92. (10.1105/tpc.004838)
News articles
Contact Details
Themâu ymchwil
Arbenigeddau
- Bioleg foleciwlaidd
- Datblygu Planhigion
- Geneteg
- Biocemeg planhigion
