Trosolwg
Rwy'n ymchwilydd ôl-ddoethurol sydd â diddordeb mewn sbectrosgopeg cyseiniant magnetig trylediad (dMRS), MRI trylediad (dMRI), a modelu bioffisegol cyfrifiadurol microstrwythur yr ymennydd. Mae fy ymchwil yn canolbwyntio ar ddeall strwythurau cellog ar raddfa fanwl, cyfnewid dŵr, a threfniadaeth meinwe yn yr ymennydd, ac ar ddatblygu dulliau a modelau MRI datblygedig i archwilio'r nodweddion hyn yn anfewnwthiol.
Ar hyn o bryd, rwy'n Ymchwilydd Gwyddonol Arweiniol ym mhrosiect DEPICT, lle rydym yn ymchwilio i newidiadau microstrwythurol sy'n gysylltiedig â chlefyd Alzheimer (AD) a chlefyd Parkinson (PD). Mae fy ngwaith yn cynnwys datblygu a chymhwyso caffaeliadau MRI trylediad uwch a modelau bioffisegol i nodweddu microstrwythur yr ymennydd a nodi marcwyr meintiol o newidiadau sy'n gysylltiedig â chlefydau.
Yn fwy eang, mae gen i ddiddordeb mewn pontio mesuriadau MRI gyda mecanweithiau cellog a bioffisegol sylfaenol, gan gyfuno MRI arbrofol, modelu cyfrifiadurol, efelychiadau, a dadansoddi delweddau meintiol i wella ein dealltwriaeth o strwythur a patholeg yr ymennydd.
Cyhoeddiad
2026
- Şimşek, K. et al. 2026. The role of dendritic spines in water exchange measurements with diffusion MRI: time‐dependent single diffusion encoding MRI. NMR in Biomedicine 39 (10) e70382. (10.1002/nbm.70382)
- Chakwizira, A. et al., 2026. The role of dendritic spines in water exchange measurements with diffusion MRI: Double diffusion encoding and free‐waveform MRI. NMR in Biomedicine 39 (7) e70315. (10.1002/nbm.70315)
2025
- Schading‐Sassenhausen, S. et al., 2025. Metabolic and structural alterations in the motor system following spinal cord injury: An in‐Vivo 1 H ‐ MR spectroscopy investigation. Journal of Neuroscience Research 103 (7) e70071. (10.1002/jnr.70071)
- Şimşek, K. et al. 2025. Age-trajectories of higher-order diffusion properties of major brain metabolites in cerebral and cerebellar grey matter using in vivo diffusion-weighted MR spectroscopy at 3T. Aging Cell 24 (5) e14477. (10.1111/acel.14477)
2024
- Stamatelatou, A. et al., 2024. Diffusion‐weighted MR spectroscopy of the prostate. Magnetic Resonance in Medicine (10.1002/mrm.30141)
- Ligneul, C. et al., 2024. Diffusion‐weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling. Magnetic Resonance in Medicine 91 (3), pp.860-885. (10.1002/mrm.29877)
Erthyglau
- Şimşek, K. et al. 2026. The role of dendritic spines in water exchange measurements with diffusion MRI: time‐dependent single diffusion encoding MRI. NMR in Biomedicine 39 (10) e70382. (10.1002/nbm.70382)
- Chakwizira, A. et al., 2026. The role of dendritic spines in water exchange measurements with diffusion MRI: Double diffusion encoding and free‐waveform MRI. NMR in Biomedicine 39 (7) e70315. (10.1002/nbm.70315)
- Schading‐Sassenhausen, S. et al., 2025. Metabolic and structural alterations in the motor system following spinal cord injury: An in‐Vivo 1 H ‐ MR spectroscopy investigation. Journal of Neuroscience Research 103 (7) e70071. (10.1002/jnr.70071)
- Şimşek, K. et al. 2025. Age-trajectories of higher-order diffusion properties of major brain metabolites in cerebral and cerebellar grey matter using in vivo diffusion-weighted MR spectroscopy at 3T. Aging Cell 24 (5) e14477. (10.1111/acel.14477)
- Stamatelatou, A. et al., 2024. Diffusion‐weighted MR spectroscopy of the prostate. Magnetic Resonance in Medicine (10.1002/mrm.30141)
- Ligneul, C. et al., 2024. Diffusion‐weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling. Magnetic Resonance in Medicine 91 (3), pp.860-885. (10.1002/mrm.29877)
Contact Details
Themâu ymchwil
Arbenigeddau
- MRI trylediad
- Sbectrosgopeg MR trylediad
- Microstrwythur
- modelu cyfrifiadurol