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Yr Athro Brad Spiller
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- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Brad Spiller
Athro llawn
Trosolwyg
Yr Athro Owen B. Spiller (ORCID 0000-0002-9117-6911)
Arweinydd Gwarcheidwaid Gwrthfiotigau, Ysgol Feddygaeth Prifysgol Caerdydd | Cadeirydd, Grŵp Cynghrair AMR GW4
Rwy'n Bennaeth Microbioleg Feddygol yn yr Is-adran Heintiau ac Imiwnedd, Prifysgol Caerdydd, wedi'i leoli yn Ysbyty Athrofaol Cymru. Rwyf yn dal rolau Microbiolegydd Ymgynghorol Anrhydeddus gydag UKHSA ac Ymddiriedolaeth GIG Cwm Taf Morgannwg ac rwyf wedi bod yn Athro Cyswllt Cynorthwyol ym Mhrifysgol Gorllewin Awstralia ers 2014.
Mae fy labordy yn arwain astudiaethau cydweithredol (a ariennir gan Sefydliad Ineos Rhydychen) ar heintiau bacteriol Gram-positif mewn sepsis newyddenedigol mewn gwledydd incwm isel i ganolig (LMICs), fel rhan o gam II BARNARDS (Baich Ymwrthedd i Wrthfiotigau mewn Newydd-anedig o Gymdeithasau sy'n Datblygu). Rydym yn nodweddu sensitifrwydd gwrthficrobaidd, dilyniannau genom cyfan, virulence, a throsglwyddo genynnau ymwrthedd llorweddol mewn ynyswyr llif gwaed. Mae safleoedd cydweithredol yn cynnwys Pacistan, Nigeria, Bangladesh (BARNARDS II), Niger (Combacte-Care), ac Uganda (PROGRESS).
Mae fy nhîm hefyd yn arwain ymdrechion i safoni penderfyniad ymwrthedd gwrthficrobaidd (AMR) mewn Legionella pneumophila a rhywogaethau cysylltiedig, mewn cydweithrediad â labordai cyfeirio Ewropeaidd a'r CDC.
Ers 2013, rwyf wedi bod yn awdurdod blaenllaw ar Ureaplasma spp. a Mycoplasma hominis, ac wedi gwasanaethu fel Ysgrifennydd Cyffredinol y Sefydliad Rhyngwladol Mycoplasmoleg (2014–2021). Fy labordy yw Labordy Cyfeirio Profion Sensitifrwydd Gwrthficrobaidd y DU ar gyfer samplau clinigol Ureaplasma a M. hominis a gyflwynwyd i UKHSA ac Iechyd Cyhoeddus Cymru. Rhennir diweddariadau ar gyfer Microbioleg Feddygol drwy grŵp Ymchwil Ymwrthedd Gwrthficrobaidd Cymru Gyfan (@AWARRe ar Twitter).
Mae astudiaethau parhaus yn archwilio mecanweithiau AMR a phathogeneticrwydd ar draws pathogenau lluosog, gan gynnwys Mollicutes (bacteria heb wal gelloedd), bacteria Gram-negyddol (L. pneumophila, Klebsiella pneumoniae, E. coli), a bacteria Gram-positif ymledol (Streptococcus agalactiae, S. sinensis, S. viridans, S. cristatus).
Mae'r labordy yn gartref i gyfleuster Dilyniannu Genom Cyfan Bacteriol Prifysgol Caerdydd, mewn partneriaeth â Pharc Genynnau Cymru, Iechyd Cyhoeddus Cymru (prosiect ARGENT), a Sefydliad Rhydychen Ineos. Mae'r meysydd ffocws yn cynnwys sepsis (newyddenedigol ac oedolion) yn y DU, Cuba, Uganda, a Ghana; Achosion o Legionellosis yn y DU; ac wrethitis/cervicitis amhenodol mewn cleifion iechyd rhywiol yng Nghymru.
Mae ein hymchwil yn cynnwys gwerthuso profion diagnostig masnachol, datblygu gwrthficrobyddion newydd a llwyfannau sgrinio AST trwybwn uchel, a nodi genynnau virulence. Yn nodedig, mae'r Labordy Spiller yn parhau i fod yr unig grŵp i newid Ureaplasma parvum yn enetig ar gyfer delweddu ex vivo mewn modelau heintiau esgynnol arbrofol (gyda Phrifysgol Caeredin).
Gyda chydweithrediadau ehangu trwy AWARRe, mae ein labordy yn ymchwilio'n weithredol i enynnau AMR sy'n dod i'r amlwg (ee, mcr-1, NDM-5) in vitro ac in vivo.
Ers 2021, rydym hefyd wedi sefydlu safleoedd ymchwil dwyochrog ar gyfer gwyliadwriaeth AMR yn Ysbyty Addysgu Cape Coast (Ghana) ac Ysbyty Atgyfeirio Cenedlaethol Prifysgol Makerere a Kawempe (Uganda).
Cyhoeddiad
2025
- Michel, C. et al. 2025. Occurrence of macrolides resistance in Legionella pneumophila ST188: results of the Belgian epidemiology and resistome investigation of clinical isolates. International Journal of Infectious Diseases 153, article number: 107786. (10.1016/j.ijid.2025.107786)
- Kyohere, M. et al. 2025. Epidemiology of Group B Streptococcus: Maternal colonization and infant disease in Kampala, Uganda. Open Forum Infectious Diseases (10.1093/ofid/ofaf167)
- Portal, E. A. R. et al. 2025. Agar-dilution is comparable to broth dilution for MIC determination in Streptococcus agalactiae. Antibiotics 14(2), article number: 156. (10.3390/antibiotics14020156)
- Sewell, M. et al. 2025. Broth microdilution protocol for determining antimicrobial susceptibility of Legionella pneumophila to clinically relevant antimicrobials. Journal of Microbiological Methods 228, article number: 107071. (10.1016/j.mimet.2024.107071)
2024
- Davies, H. G. et al. 2024. Etiology and antimicrobial resistance of culture-positive infections in Ugandan infants: a cohort study of 7000 neonates and infants. Open Forum Infectious Diseases 11(S3), pp. S157–S164. (10.1093/ofid/ofae629)
- Hookham, L. et al. 2024. Infectious causes of stillbirths: a descriptive etiological study in Uganda. Open Forum Infectious Diseases 11(S3), pp. S165–S172. (10.1093/ofid/ofae606)
- Dolton, G. et al. 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134(18), article number: e164535. (10.1172/JCI164535)
- van Gorp, C. et al. 2024. Antenatal ureaplasma infection causes colonic mucus barrier defects: implications for intestinal pathologies. International Journal of Molecular Sciences 25(7), article number: 4000. (10.3390/ijms25074000)
- Portal, E. A. R. et al. 2024. Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria. Nature Communications 15(1), article number: 2302. (10.1038/s41467-024-45673-6)
- Agyare, E. et al. 2024. Antimicrobial stewardship capacity and antibiotic utilisation practices in the Cape Coast Teaching Hospital, Ghana: A point prevalence survey study. PLoS ONE 19(1), article number: e0297626. (10.1371/journal.pone.0297626)
2023
- Jay, C. et al. 2023. Cellular immunity to SARS-CoV-2 following intrafamilial exposure in seronegative family members. Frontiers in Immunology 14, article number: 1248658. (10.3389/fimmu.2023.1248658)
- David, S. et al. 2023. Genomic surveillance of multidrug-resistant Klebsiella in Wales reveals persistent spread of Klebsiella pneumoniae ST307 and adaptive evolution of pOXA-48-like plasmids. Microbial Genomics 9(5) (10.1099/mgen.0.001016)
- Heiter, J. et al. 2023. Effects of multiple pro-inflammatory stimuli in utero on the ileum of extremely premature ovine fetuses. Frontiers in Immunology 14, article number: 1150208. (10.3389/fimmu.2023.1150208)
- Khan, U. B., Portal, E. A. R., Sands, K., Lo, S., Chalker, V. J., Jauneikaite, E. and Spiller, O. B. 2023. Genomic analysis reveals new integrative conjugal elements and transposons in GBS conferring antimicrobial resistance. Antibiotics 12(3), article number: 544. (10.3390/antibiotics12030544)
2022
- van Gorp, C. et al. 2022. Antenatal Ureaplasma infection induces ovine small intestinal goblet cell defects: a strong link with NEC pathology. Tissue Barriers, article number: 2158016. (10.1080/21688370.2022.2158016)
- Day, J. et al. 2022. Phenotypic and genotypic antimicrobial susceptibility patterns of the emerging human respiratory pathogen Mycoplasma amphoriforme isolated from the UK and Denmark. Journal of Antimicrobial Chemotherapy 77(11), pp. 3126-3129. (10.1093/jac/dkac293)
- Dakorah, M. P. et al. 2022. Utilising cumulative antibiogram data to enhance antibiotic stewardship capacity in the Cape Coast Teaching Hospital, Ghana. Antimicrobial Resistance and Infection Control 11, article number: 122. (10.1186/s13756-022-01160-5)
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
- Sands, K. et al. 2022. Characterisation of Staphylococci species from neonatal blood cultures in low- and middle-income countries. BMC Infectious Diseases 22(1), article number: 593. (10.1186/s12879-022-07541-w)
- Khan, U. B., Jauneikaite, E., Andrews, R., Chalker, V. J. and Spiller, O. B. 2022. Identifying large-scale recombination and capsular switching events in Streptococcus agalactiae strains causing disease in adults in the UK between 2014 and 2015. Microbial Genomics 8(3), article number: 783. (10.1099/mgen.0.000783)
- Silwedel, C. et al. 2022. Ureaplasma-driven neonatal neuroinflammation: novel insights from an ovine model. Cellular and Molecular Neurobiology 43, pp. 785-795. (10.1007/s10571-022-01213-8)
- Acolatse, J. E. E. et al. 2022. Environmental surveillance of ESBL and carbapenemase-producing gram-negative bacteria in a Ghanaian Tertiary Hospital. Antimicrobial Resistance and Infection Control 11(1), article number: 49. (10.1186/s13756-022-01090-2)
- Sands, K., Spiller, O. B., Thomson, K., Portal, E. A. R., Iregbu, K. C. and Walsh, T. R. 2022. Early-onset neonatal sepsis in low- and middle-income countries: current challenges and future opportunities. Infection and Drug Resistance 2022, pp. 933—946. (10.2147/IDR.S294156)
- Boostrom, I., Portal, E. A. R., Spiller, O. B., Walsh, T. R. and Sands, K. 2022. Comparing long-read assemblers to explore the potential of a sustainable low-cost, low-infrastructure approach to sequence antimicrobial resistant bacteria with Oxford nanopore sequencing. Frontiers in Microbiology 13, article number: 796465. (10.3389/fmicb.2022.796465)
- Preval, N. M. R., Spiller, O. B., Mondeja Rodríguez, B. A., Morales, R. S., Cintra, Y. R. and Rivera-Tapia, J. A. 2022. Antibiotic resistance among clinical Ureaplasma isolates from Cuban individuals between 2013 and 2018. Journal of Medical Microbiology 71(2), article number: 1477. (10.1099/jmm.0.001477)
2021
- Boostrom, I. et al. 2021. Evaluation of the MYCOPLASMA IST3 urogenital mycoplasma assay in an international multicentre trial. Journal of Antimicrobial Chemotherapy 76(12), pp. 3175-3182. (10.1093/jac/dkab320)
- Spiller-Boulter, O., Paukner, S., Boostrom, I., Sands, K., Portal, E. A. R. and Spiller, O. B. 2021. Determination of in vitro antimicrobial susceptibility for Lefamulin (Pleuromutilin) for Ureaplasma Spp. and Mycoplasma hominis. Antibiotics 10(11), article number: 1370. (10.3390/antibiotics10111370)
- Sharratt, M. et al. 2021. Defining fluoroquinolone resistance-mediating mutations from non-resistance polymorphisms in Mycoplasma hominis Topoisomerases. Antibiotics 10(11), article number: 1379. (10.3390/antibiotics10111379)
- Rowlands, R., Kragh, K., Sahu, S., Maddocks, S., Bolhuis, A., Spiller, O. and Beeton, M. 2021. A requirement for flow to enable the development of Ureaplasma parvum biofilms in vitro. Journal of Applied Microbiology 131(5), pp. 2579-2585. (10.1111/jam.15120)
- Goedicke-Fritz, S. et al. 2021. Detection of volatile organic compounds as potential novel biomarkers for chorioamnionitis - proof of experimental models. Frontiers in Pediatrics 9, article number: 698489. (10.3389/fped.2021.698489)
- Portal, E. et al. 2021. Legionella antibiotic susceptibility testing: is it time for international standardization and evidence-based guidance?. Journal of Antimicrobial Chemotherapy 76(5), pp. 1113-1116. (10.1093/jac/dkab027)
- Portal, E., Sands, K., Portnojs, A., Chalker, V. . J. and Spiller, O. B. 2021. Legionella antimicrobial sensitivity testing: comparison of microbroth dilution with BCYE and LASARUS solid media. Journal of Antimicrobial Chemotherapy 76(5), pp. 1197-1204. (10.1093/jac/dkaa535)
- Ophelders, D. R. M. G. et al. 2021. Screening of chorioamnionitis using volatile organic compound detection in exhaled breath: a pre-clinical proof of concept study. Frontiers in Pediatrics 9, article number: 617906. (10.3389/fped.2021.617906)
- Chalker, V. J. et al. 2021. Tetracycline resistance mediated by tet(M) has variable integrative conjugative element composition in Mycoplasma hominis isolated in the United Kingdom from 2005-2015.. Antimicrobial Agents and Chemotherapy 65, article number: e02513-20. (10.1128/AAC.02513-20)
2020
- Morris, D. J., Jones, L. C., Davies, R. L., Sands, K., Portal, E. and Spiller, O. B. 2020. MYCO WELL D-ONE detection of Ureaplasma spp. and Mycoplasma hominis in sexual health patients in Wales. European Journal of Clinical Microbiology and Infectious Diseases 39, pp. 2427-2440. (10.1007/s10096-020-03993-7)
- Heymans, C. et al. 2020. Prophylactic intra-uterine β-cyclodextrin administration during intra-uterine Ureaplasma parvum infection partly prevents liver inflammation without interfering with the enterohepatic circulation of the fetal sheep. Nutrients 12(5), article number: 1312. (10.3390/nu12051312)
- Yang, Q. E. et al. 2020. Compensatory mutations modulate the competitiveness and dynamics of plasmid-mediated colistin resistance in Escherichia coli clones. ISME Journal 14, pp. 861-865. (10.1038/s41396-019-0578-6)
- Heymans, C. et al. 2020. Chronic intra-uterine ureaplasma parvum infection induces injury of the enteric nervous system in ovine fetuses. Frontiers in Immunology 11(189) (10.3389/fimmu.2020.00189)
- Spiller, O. B., Rees, C. L., Morris, D. J., Davies, R. L. and Jones, L. C. 2020. Mycoplasma genitalium prevalence in Welsh sexual health patients: low antimicrobial resistance markers and no association of symptoms to bacterial load. Microbial Pathogenesis 139, article number: 103872. (10.1016/j.micpath.2019.103872)
- Beeton, M. L. et al. 2020. Mycoplasma pneumoniae infections, 11 countries in Europe and Israel, 2011 to 2016. Eurosurveillance 25(2), article number: pii=1900112. (10.2807/1560-7917.ES.2020.25.2.1900112)
- Pavlidis, I., Spiller, O. B., Sammut Demarco, G., MacPherson, H., Howie, S. E. M., Norman, J. E. and Stock, S. J. 2020. Cervical epithelial damage promotes Ureaplasma parvum ascending infection, intrauterine inflammation and preterm birth induction in mice. Nature Communications 11, article number: 199. (10.1038/s41467-019-14089-y)
2019
- Hütten, M. C. et al. 2019. Detrimental effects of an inhaled phosphodiesterase-4 inhibitor on lung inflammation in ventilated preterm lambs exposed to chorioamnionitis are dose dependent. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32(6), pp. 396-404. (10.1089/jamp.2019.1528)
- van Gorp, C. et al. 2019. Protection of the ovine fetal gut against ureaplasma-induced chorioamnionitis: a potential role for plant sterols. Nutrients 11(5), pp. -., article number: 968. (10.3390/nu11050968)
2017
- Yang, Q. et al. 2017. Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms. Nature Communications 8, article number: 2054. (10.1038/s41467-017-02149-0)
- Gussenhoven, R. et al. 2017. The paradoxical effects of chronic intra-amniotic Ureaplasma exposure on ovine fetal brain development. Developmental Neuroscience 39(6), pp. 472-486. (10.1159/000479021)
- Willems, M. G. M. et al. 2017. Pulmonary vascular changes in extremely preterm sheep after intra-amniotic exposure to Ureaplasma parvum and lipopolysaccharide. PLoS ONE 12(6), article number: e0180114. (10.1371/journal.pone.0180114)
- Spiller, O. B. 2017. Emerging pathogenic respiratory mycoplasma hominis infections in lung transplant patients: time to reassesses it's role as a pathogen?. EBioMedicine 19, pp. 8-9. (10.1016/j.ebiom.2017.05.002)
- Hillitt, K. L., Jenkins, R. E., Spiller, O. B. and Beeton, M. L. 2017. Antimicrobial activity of Manuka honey against antibiotic resistant strains of the cell wall free bacteria ureaplasma parvum and Ureaplasma urealyticum. Letters In Applied Microbiology 64(3), pp. 198-202. (10.1111/lam.12707)
- Beeton, M. and Spiller, O. B. 2017. Antibiotic resistance among Ureaplasma spp isolates: cause for concern?. Journal of Antimicrobial Chemotherapy 72(2), pp. 330-337. (10.1093/jac/dkw425)
- Kemp, M. W. et al. 2017. Fetal Ureaplasma parvum bacteraemia as a function of gestation-dependent complement insufficiency: evidence from a sheep model of pregnancy. American Journal of Reproductive Immunology 77(1), article number: e12599. (10.1111/aji.12599)
- Stock, S. J. et al. 2017. Intrauterine Candida albicans infection causes systemic fetal candidiasis with progressive cardiac dysfunction in a sheep model of early pregnancy. Reproductive Sciences 24(1), pp. 77-84. (10.1177/1933719116649697)
2016
- Jironkin, A., Brown, R. J., Underwood, A., Chalker, V. J. and Spiller, O. B. 2016. Genomic determination of minimum multi-locus sequence typing schemas to represent the genomic phylogeny of Mycoplasma hominis.. BMC Genomics 17, article number: 964. (10.1186/s12864-016-3284-z)
- Beeton, M. L., Maxwell, N. C., Chalker, V. J., Brown, R. J., Aboklaish, A. F. and Spiller, O. B. 2016. Isolation of separate Ureaplasma species from endotracheal secretions of twin patients. Pediatrics 138(2), article number: e20160565. (10.1542/peds.2016-0565)
- Aboklaish, A., Ahmed, S., McAllister, D., Cassell, G., Zheng, X. and Spiller, O. B. 2016. Differential recognition of the Multiple Banded Antigen isoforms across Ureaplasma parvum and Ureaplasma urealyticum species by monoclonal antibodies. Journal of Microbiological Methods 127, pp. 13-19. (10.1016/j.mimet.2016.05.015)
- Brown, R., Nguipdop-Djomo, P., Zhao, H., Stanford, E., Spiller, O. B. and Chalker, V. J. 2016. Mycoplasma pneumoniae epidemiology in England and Wales: a national perspective. Frontiers in Microbiology 7, article number: 157. (10.3389/fmicb.2016.00157)
- Kemp, M. W. et al. 2016. Outside-in? Acute fetal systemic inflammation in very preterm chronically catheterized sheep fetuses is not driven by cells in the fetal blood. American Journal of Obstetrics and Gynecology 214(2), pp. 281.e1-281.e10. (10.1016/j.ajog.2015.09.076)
- Beeton, M. L., Chalker, V. J., Jones, L. C., Maxwell, N. C. and Spiller, O. B. 2016. Antibiotic resistance among clinical Ureaplasma Isolates Recovered from Neonates in England and Wales between 2007 and 2013. Antimicrobial Agents and Chemotherapy 60(1), pp. 52-56. (10.1128/AAC.00889-15)
2015
- Nesargikar, P., Pino-Chavez, G., Spiller, O. B., Fraser, D. J., Jenkins, R. H. and Chavez, R. 2015. Single dose sCR1 attenuates renal ischemia reperfusion injury in rats despite early reconstitution of the complement system [Abstract]. Transplant International 28(S4), pp. 62-62. (10.1111/tri.12700)
- Brown, R., Spiller, O. B. and Chalker, V. J. 2015. Molecular typing of mycoplasma pneumoniae: where do we stand?. Future Microbiology 10(11), pp. 1793-1795. (10.2217/fmb.15.96)
- Brown, R., Holden, M. T. G., Spiller, O. B., Chalker, V. J. and Ledeboer, N. A. 2015. Development of a multilocus sequence typing scheme for molecular typing of mycoplasma pneumoniae. Journal of Clinical Microbiology 53(10), pp. 3195-3203. (10.1128/JCM.01301-15)
- Furfaro, L. L., Spiller, O. B., Keelan, J. A. and Payne, M. S. 2015. In vitro activity of solithromycin and its metabolites, CEM-214 and N-acetyl-CEM-101, against 100 clinical Ureaplasma spp. isolates compared with azithromycin. International Journal of Antimicrobial Agents 46(3), pp. 319-324. (10.1016/j.ijantimicag.2015.04.015)
- Ahmed, S. et al. 2015. Comparison of complement activity in adult and preterm sheep serum. American Journal of Reproductive Immunology 73(3), pp. 232-241. (10.1111/aji.12299)
2014
- Aboklaish, A., Dordet-Frisoni, E., Citti, C., Toleman, M. A., Glass, J. I. and Spiller, O. B. 2014. Random insertion and gene disruption via transposon mutagenesis of Ureaplasma parvum using a mini-transposon plasmid. International Journal of Medical Microbiology 304(8), pp. 1218-1225. (10.1016/j.ijmm.2014.09.003)
- Kemp, M. W. et al. 2014. Maternal intravenous administration of azithromycin results in significant fetal uptake in a sheep model of second trimester pregnancy. Antimicrobial Agents and Chemotherapy 58(11), pp. 6581-6591. (10.1128/AAC.03721-14)
- Kemp, M. W. et al. 2014. Repeated maternal intramuscular or intraamniotic erythromycin incompletely resolves intrauterine Ureaplasma parvum infection in a sheep model of pregnancy. American Journal of Obstetrics and Gynecology 211(2), pp. 134.e1-134.e9. (10.1016/j.ajog.2014.02.025)
- Lowe, J., Watkins, W., Edwards, M., Spiller, O., Jacqz-Aigrain, E., Kotecha, S. and Kotecha, S. 2014. Association between pulmonary Ureaplasma colonization and bronchopulmonary dysplasia in preterm infants: updated systematic review and meta-analysis. The Pediatric Infectious Disease Journal 33(7), pp. 697-702. (10.1097/INF.0000000000000239)
- Miura, Y. et al. 2014. Maternal intravenous treatment with either azithromycin or solithromycin clears Ureaplasma parvum from the amniotic fluid in an ovine model of intrauterine infection. Antimicrobial Agents and Chemotherapy 58(9), pp. 5413-5420. (10.1128/AAC.03187-14)
- Van Den Berg, C., Tambourgi, D. V., Clark, H. W., Hoong, S. J., Spiller, O. and McGreal, E. 2014. Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor. The Journal of Immunology 192(4), pp. 1787-1795. (10.4049/jimmunol.1301920)
- Brown, R., Chalker, V. J. and Spiller, O. B. 2014. Mycoplasma hominis variable adherence-associated antigen: A major adhesin and highly variable surface membrane protein. Advances in Microbiology 4(11), pp. 736-746. (10.4236/aim.2014.411080)
2013
- Payne, M. S., Tabone, T., Kemp, M. W., Keelan, J. A., Spiller, O. B., Newnham, J. P. and Carroll, K. C. 2013. High-resolution melt PCR analysis for genotyping of Ureaplasma parvum isolates directly from clinical samples. Journal of Clinical Microbiology 52(2), pp. 599-606. (10.1128/JCM.03036-13)
- Triantafilou, M., De Glanville, B., Aboklaish, A. F., Spiller, O. B., Kotecha, S. and Triantafilou, K. 2013. Synergic activation of Toll-Like Receptor (TLR) 2/6 and 9 in response to ureaplasma parvum & urealyticum in human amniotic epithelial cells. PLoS ONE 8(4), article number: e61199. (10.1371/journal.pone.0061199)
2012
- Beeton, M. L., Daha, M. R., El-Shanawany, T., Jolles, S., Kotecha, S. and Spiller, O. B. 2012. Serum killing of 'ureaplasma parvum' shows serovar-determined susceptibility for normal individuals and common variable immuno-deficiency patients. Immunobiology 217(2), pp. 187-194. (10.1016/j.imbio.2011.07.009)
- McGreal, E. P., Hearne, K. and Spiller, O. B. 2012. Off to a slow start: under-development of the complement system in term newborns is more substantial following premature birth. Immunobiology 217(2), pp. 176-186. (10.1016/j.imbio.2011.07.027)
2011
- Pinkert, S., Klingel, K., Lindig, V., Dorner, A., Zeichhardt, H., Spiller, O. B. and Fechner, H. 2011. Virus-host coevolution in a persistently coxsackievirus B3-infected cardiomyocyte cell line. Journal of Virology 85(24), pp. 13409-13419. (10.1128/JVI.00621-11)
- Beeton, M. L. et al. 2011. Role of pulmonary infection in the development of chronic lung disease of prematurity. European Respiratory Journal 37(6), pp. 1424-1430. (10.1183/09031936.00037810)
2010
- Davies, P. L., Spiller, O. B., Beeton, M. L., Maxwell, N. C., Remold-O'Donnell, E. and Kotecha, S. 2010. Relationship of proteinases and proteinase inhibitors with microbial presence in chronic lung disease of prematurity. Thorax 65(3), pp. 246-251. (10.1136/thx.2009.116061)
- McGreal, E. P. et al. 2010. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802(7-8), pp. 649-658. (10.1016/j.bbadis.2010.04.005)
2009
- Beeton, M. L., Chalker, V. J., Maxwell, N. C., Kotecha, S. and Spiller, O. B. 2009. Concurrent titration and determination of antibiotic resistance in 'ureaplasma' species with identification of novel point mutations in genes associated with resistance. Antimicrobial Agents and Chemotherapy 53(5), pp. 2020-2027. (10.1128/AAC.01349-08)
- Wall, S. R., Wat, D., Spiller, O. B., Gelder, C. M., Kotecha, S. and Doull, I. J. M. 2009. The viral aetiology of croup and recurrent croup. Archives of Disease in Childhood 94(5), pp. 359-360. (10.1136/adc.2008.142984)
- Okroj, M. et al. 2009. Characterization of the complement inhibitory function of rhesus rhadinovirus complement control protein (RCP). Journal of Biological Chemistry 284(1), pp. 505-514. (10.1074/jbc.M806669200)
- Pinkert, S. et al. 2009. Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor. Circulation 120(23), pp. 2358-2366. (10.1161/CIRCULATIONAHA.108.845339)
- Beeton, M. L., Chalker, V. J., Kotecha, S. and Spiller, O. B. 2009. Comparison of full gyrA, gyrB, parC and parE gene sequences between all Ureaplasma parvum and Ureaplasma urealyticum serovars to separate true fluoroquinolone antibiotic resistance mutations from non-resistance polymorphism. Journal of Antimicrobial Chemotherapy 64(3), pp. 529-538. (10.1093/jac/dkp218)
2008
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2006
- Spiller, O. B., Mark, L., Blue, C. E., Proctor, D. G., Aitken, J. A., Blom, A. M. and Blackbourn, D. J. 2006. Dissecting the regions of virion-associated Kaposi's sarcoma-associated herpesvirus complement control protein required for complement regulation and cell binding. Journal of Virology 80(8), pp. 4068-4078. (10.1128/JVI.80.8.4068-4078.2006)
2005
- Spiller, O. B., Goodfellow, I. G., Evans, D. and Blom, A. M. 2005. Inhibition of coxsackie B virus infection by soluble forms of its receptors: binding affinities, altered particle formation, and competition with cellular receptors. Journal of Virology 79(18), pp. 12016-12024. (10.1128/JVI.79.18.12016-12024.2005)
2003
- Spiller, O. B., Blackbourn, D. J., Mark, L., Proctor, D. G. and Blom, A. M. 2003. Functional activity of the complement regulator encoded by Kaposi's sarcoma-associated herpesvirus. Journal of Biological Chemistry 278(11), pp. 9283-9289. (10.1074/jbc.M211579200)
- Spiller, O. B., Robinson, M., O'Donnell, E., Milligan, S., Morgan, B. P., Davison, A. J. and Blackbourn, D. J. 2003. Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein. Journal of Virology 77(1), pp. 592-599. (10.1128/JVI.77.1.592-599.2003)
Erthyglau
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- Spiller, O. B., Robinson, M., O'Donnell, E., Milligan, S., Morgan, B. P., Davison, A. J. and Blackbourn, D. J. 2003. Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein. Journal of Virology 77(1), pp. 592-599. (10.1128/JVI.77.1.592-599.2003)
- Portal, E. A. R. et al. 2024. Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria. Nature Communications 15(1), article number: 2302. (10.1038/s41467-024-45673-6)
- Agyare, E. et al. 2024. Antimicrobial stewardship capacity and antibiotic utilisation practices in the Cape Coast Teaching Hospital, Ghana: A point prevalence survey study. PLoS ONE 19(1), article number: e0297626. (10.1371/journal.pone.0297626)
- Khan, U. B., Portal, E. A. R., Sands, K., Lo, S., Chalker, V. J., Jauneikaite, E. and Spiller, O. B. 2023. Genomic analysis reveals new integrative conjugal elements and transposons in GBS conferring antimicrobial resistance. Antibiotics 12(3), article number: 544. (10.3390/antibiotics12030544)
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
- Sands, K. et al. 2022. Characterisation of Staphylococci species from neonatal blood cultures in low- and middle-income countries. BMC Infectious Diseases 22(1), article number: 593. (10.1186/s12879-022-07541-w)
- Sands, K., Spiller, O. B., Thomson, K., Portal, E. A. R., Iregbu, K. C. and Walsh, T. R. 2022. Early-onset neonatal sepsis in low- and middle-income countries: current challenges and future opportunities. Infection and Drug Resistance 2022, pp. 933—946. (10.2147/IDR.S294156)
- Portal, E., Sands, K., Portnojs, A., Chalker, V. . J. and Spiller, O. B. 2021. Legionella antimicrobial sensitivity testing: comparison of microbroth dilution with BCYE and LASARUS solid media. Journal of Antimicrobial Chemotherapy 76(5), pp. 1197-1204. (10.1093/jac/dkaa535)
Ymchwil
Ymchwiliad i sepsis newyddenedigol mewn gwledydd incwm isel i ganolig (LMIC)
Labordy Spiller yw'r ganolfan ar gyfer nodweddu pathogenau Gram-positif sy'n cael eu hynysu o lif gwaed newydd-anedig yn y 30 diwrnod cyntaf o fywyd. Nodweddir sensitifrwydd gwrthficrobaidd, dadansoddiad dilyniant genom cyfan, virulence a throsglwyddo genynnau ymwrthedd gwrthficrobaidd o un bacteria i'r llall ar gyfer ynysu o Bacistan, Nigeria, Bangladesh, Rwanda, Ethiopia, De Affrica (cam I BARNARDS) sydd bellach wedi ehangu i ymchwiliadau ar raddfa fwy mewn sawl safle yn y 3 gwlad gyntaf ar gyfer BARNARDS cam II), Niger (Combacte-Care), ac Uganda (PROGRESS). Mae cydweithrediadau gweithredol ar gyfer yr astudiaethau hyn yn cynnwys Prifysgol Rhydychen, Médecins Sans Frontières a St. George's, Prifysgol Llundain. Ar hyn o bryd mae'r astudiaethau hyn yn ymestyn i wella offer diagnostig microbiolegol sy'n fwy addas i leoliadau adnoddau isel i alluogi triniaeth gyflymach a mwy gwybodus o heintiau Gram-positif ymledol mewn LMICs.
Cyfryngau Legionella Newydd Chwyldroadol wedi'u patentu.
Mewn cydweithrediad ag Asiantaeth Diogelwch Iechyd y DU, mae labordy Spiller wedi patentu cyfrwng Legionella solet newydd (Legionella Antimicrobial Susceptibility And Resistance Universal Screening medium: LASARUS) sy'n disodli cyfrwng sy'n cynnwys siarcol wedi'i actifadu. Mae'r cyfrwng newydd yn dryloyw ac nid yw'n amsugno gwrthficrobaidd fel pob agar solet traddodiadol - ac ar hyn o bryd mae'n cael ei addasu i gynnwys Legionella spp. cromogenau penodol. Bydd hyn yn galluogi awtomeiddio ar gyfer sgrinio Legionella - datblygiad allweddol i ymateb i'r profion cynyddol sy'n ofynnol gan ddeddfwriaeth Cyfarwyddeb Dŵr Yfed yr UE. Ar hyn o bryd mae labordy Spiller hefyd yn arwain y gwaith o safoni rhyngwladol profion sensitifrwydd gwrthficrobaidd ar gyfer niwmonia Legionella a Legionella clinigol arall rhywogaethau mewn labordai cyfeirio Legionella ledled Ewrop ac yn y CDC. Mae'r prosiect olaf hwn yn cael ei gefnogi ar hyn o bryd trwy gyllid gan Gymdeithas Microbioleg Glinigol a Chlefydau Heintus Ewrop (ESCMID).
Ymchwil Grŵp B Strep (Streptococcus agalactiae)
Mae gan y labordy ddiddordeb arbennig mewn nodweddu symudedd Elfennau Cyfunol Integrol sy'n cario croniadau o enynnau ymwrthedd i wrthfiotigau yn GBS. Y tu hwnt i waith sy'n archwilio sepsis newyddenedigol mewn LMICs, mae gan y labordy hefyd gydweithrediadau gweithredol gydag Asiantaeth Diogelwch Iechyd y DU, Sefydliad Dilyniannu Sanger Caergrawnt a Phrifysgol St. George Llundain i nodweddu cynnydd mewn ymwrthedd gwrthficrobaidd mewn GBS ymledol ym mhob grŵp oedran.
Ymchwil Cleifion Iechyd Rhywiol
Mae labordy Spiller wedi bod yn labordy cyfeirio y DU ar gyfer profion sensitifrwydd gwrthficrobaidd o Ureaplasmas a Mycoplasmas ar gyfer Asiantaeth Diogelwch Iechyd y DU dros y degawd diwethaf. Mae hyn yn deillio o arbenigedd a gydnabyddir yn rhyngwladol ar gyfer yr heintiau hyn a drosglwyddir yn rhywiol. Cafwyd 3 ysgoloriaeth a ariannwyd yn flaenorol sydd bellach wedi dod i gasgliad yn archwilio'r epidemioleg, yr achosion o ymwrthedd gwrthficrobaidd a phathogeneticrwydd mewn cleifion Iechyd Rhywiol Cymru mewn cydweithrediad â'n harweinydd clinigol Dr. Lucy Jones. Mae'r astudiaethau hyn yn cynnwys: (1) astudiaeth MYCO WELL D-ONE (2016-2017; IRAS ) yn archwilio 1000 o gleifion o Gymru sy'n mynychu clinigau GIG Iechyd Rhywiol yn Rhondda Cynon Taf am haint gan Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis a Mycoplasma genitalium. (2) Astudiaeth UROGEN (2017-2018; IRAS ), a oedd yn cynnwys dilysu am y tro cyntaf o'r assay Mycoplasma IST3 (BioMerieiux, Ffrainc) ar 500 o gleifion iechyd rhywiol symptomatig a oedd yn mynychu clinigau iechyd rhywiol galw heibio ym mharc iechyd Keir Hardie ac Ysbyty Dewi Sant. Ehangodd y prosiect hwn i gynnwys profion diagnostig diwylliant cromogenig ar gyfer Neisseria spp., E. coli, Streptococcus Grŵp B, Candida, Trichomonas vaginalis, Gardnerella vaginalis, Staphylococcus ac Enterococcus spp. a (3) Astudiaeth y Gwarcheidwaid Gwrthfiotig (2019-2022), mewn cydweithrediad ag Iechyd Cyhoeddus Cymru ac Ymddiriedolaeth Iechyd Prifysgol Cwm Taf, a archwiliodd ddichonoldeb cyfarwyddo therapiwtig wedi'i dargedu'n gyflym ymyrraeth gan ddefnyddio profion SpeeDx masnachol ar gyfer canfod heintiau sy'n gwrthsefyll Mycoplasma a Neisseria gonorrhoea.
Ar hyn o bryd mae ein labordy yn cydweithio ag Iechyd Cyhoeddus Cymru i ailwerthuso profion sensitifrwydd gwrthficrobaidd sy'n seiliedig ar ddiwylliant ar gyfer Neisseria gonorrhoea hefyd (myfyrwraig Meistr Leanne Davies).
Bywgraffiad
Microbiolegydd Canada o Vancouver yn wreiddiol, des i i'r DU i ddechrau i archwilio osgoi microbau imiwnedd cynhenid. Rhwng 2000 a 2005 sefydlais grŵp ymchwil annibynnol drwy Raglen Cymrodoriaeth Datblygu Gyrfa Ymddiriedolaeth Wellcome, cyn ymuno â'r Adran Iechyd Plant yn Hosbis Prifysgol Cymru yn 2005 i ddatblygu thema ymchwil newydd sy'n archwilio ymwrthedd gwrthficrobaidd mewn heintiau bacteriol babanod newydd-anedig cynamserol. Arweiniodd hyn at sefydlu labordy cyfeirio blaenllaw y DU ar gyfer ymchwiliadau i Mycoplasma ac Ureaplasma Heintiau. Mae'r bacteria di-wal celloedd hyn yn ei hanfod yn gwrthsefyll y rhan fwyaf o wrthficrobau a nhw yw prif achos genedigaeth cyn y tymor ac maent yn dod i'r amlwg fel pathogenau anadlol. Yn ddiweddar, cwblheais fy nhrydydd tymor etholedig fel Ysgrifennydd Cyffredinol Sefydliad Rhyngwladol Mycoplasmology.
Yn 2012, dechreuais gydweithrediad a ariannwyd gan y Gymdeithas Frenhinol â Phrifysgol Gorllewin Awstralia i ymchwilio i batholeg microbaidd mewnwythiennol a datblygu gwrthfiotigau newydd a oedd yn ddiogel ac yn effeithiol i'w defnyddio mewn menywod beichiog. Arweiniodd y cydweithrediadau hyn at dderbyn Athrawes Cynorthwyol atodol yn Ysgol Iechyd Menywod a Babanod Prifysgol Gorllewin Awstralia, Perth, Awstralia yn 2014. Arweiniodd llwyddiant y cydweithio rhwng Caerdydd ac Awstralia at ddyrchafiad i Athro Cyswllt yn 2021.
Hefyd yn 2015, ymunais ag uned Ymchwil Gwrthficrobaidd Cymru Gyfan, dan arweiniad yr Athro Timothy Walsh, ac rwyf wedi bod yn ehangu fy ymchwil o ymwrthedd gwrthficrobaidd i facteria eraill. O ganlyniad i 2017, mae gen i brosiectau ymchwil newydd sy'n nodweddu straen Streptococcus Grŵp B wedi'u hynysu o gleifion sepsis y DU a nodweddu ynysu Legionella pnuemophilia rhag achosion o glefyd y llengfilwyr, Fe'i gelwir hefyd yn legionellosis.
Yn 2020, cefais fy mhenodi'n Bennaeth Microbioleg Feddygol lle rwy'n parhau i gefnogi ac ehangu ein tîm o ymchwilwyr gan gynnwys ymchwilwyr ar ddechrau eu gyrfa a chlinigwyr academaidd. Ar hyn o bryd rwy'n arwain nodweddu ynysion llif gwaed Gram-positif mewn babanod newydd-anedig ledled Affrica a De-ddwyrain Asia mewn cydweithrediad â Sefydliad Ineos Rhydychen (24 safle ar draws 8 gwlad: BARNARDS cam 2), yn ogystal ag arwain y safoni rhyngwladol i uno'r Profion Ymwrthedd Gwrthficrobaidd ar gyfer Legionella ledled Ewrop.
Addysg a chymwysterau:
1995: PhD (patholeg), Prifysgol British Columbia, Vancouver, B.C. Canada
Anrhydeddau a dyfarniadau
- 2000 Wellcome Trust Research Career Development Fellowship
- 2015 awarded honorary adjunct Associate Professorship at the University of Western Australia
Meysydd goruchwyliaeth
Goruchwyliaeth gyfredol
Jawaria Aziz
Leanne Davies
Maxi Sewell Sewell
Prosiectau'r gorffennol
Gorffennaf. 2023-Gorffennaf. 2027 Caitlin Farley (goruchwyliwr cynradd ar gyfer Ph.D. yn Med Micro) "Cymhariaeth o ymwrthedd gwrthficrobaidd enterococci a ffyrnigrwydd ar gyfer ynysu sepsis o LMIC a'r DU."
Apr. 2023-Apr. 2024 Leanne Davies (goruchwyliwr cynradd ar gyfer M.Phil yn Med Micro) "Gwerthusiad o'r cyfryngau ar gyfer profi tueddiad N. gonorrhoeae."
Jan. 2023-Jan. 2027 Jawaria Aziz (goruchwyliwr cynradd ar gyfer Ph.D. yn Med Micro) "Baich ymwrthedd gwrthficrobaidd Staphylococci negyddol Coagulase mewn sepsis newyddenedigol yn y LMIC"
Ionawr 2023-Ionawr 2027 Jordan Mathias (goruchwyliwr cynradd ar gyfer Ph.D. yn Med Micro) "Baich ymwrthedd gwrthficrobaidd Staphylococcus aureus mewn sepsis newydd-anedig yn y LMIC"
Jul. 2021-Jul. 2025 Ian Boostrom (goruchwyliwr cynradd ar gyfer Ph.D. yn Med Micro) "Gwella canfod rhywogaethau Legionella o ffynonellau amgylcheddol a chlinigol)"
Medi 2019-Medi 2023 Martin Sharratt (goruchwyliwr cynradd ar gyfer Ph.D. yn Med Micro) "The Antibiotic Guardian Study (therapeutics wedi'u targedu yn seiliedig ar ddiagnosteg gyflym)"
Medi 2018-Medi. 2021 Mei Li (goruchwyliwr amnewid Ph.D. yn Med Micro) "Asesu effaith fyd-eang ymwrthedd colistin cyfryngol mcr-1 / mcr-3" Amddiffynwyd yn llwyddiannus
Jan. 2018-Ionawr 2021 Katy Thomson (goruchwyliwr amnewid Ph.D. yn Med Micro) "Asesu ymwrthedd gwrthfiotig mewn pathogenau sy'n achosi sepsis newydd-anedig, marwolaethau cysylltiedig ac opsiynau triniaeth a argymhellir mewn gwledydd incwm isel a chanolig" Amddiffyn yn llwyddiannus 16/12/2022
Sep. 2017-Medi 2021 Dr. Edward Portal (goruchwyliwr cynradd ar gyfer Ph.D. yn Med Micro) "Phylogenetics, nodweddu math dilyniant a dyfalbarhad o niwmoffilia Legionella mewn cleifion a'r amgylchedd" Amddiffynwyd yn llwyddiannus 23/02/2022
Medi 2017-Medi. 2021 Dr. Uzma Basit Khan (goruchwyliwr cynradd ar gyfer Ph.D. yn Med Micro) "Cymhariaeth ymwrthedd genomig a gwrthficrobaidd manwl o ynysion Agalactiae Streptococcus y DU o oedolion i'r rhai o darddiadau byd-eang amrywiol" Amddiffyn yn llwyddiannus 22/02/2021
Medi 2014-Medi. 2018 Dr. Qui Yang (cyd-oruchwyliwr Ph.D. yn Med Micro) "Agweddau amlochrog o ymwrthedd colistin cyfryngol MCR: ffitrwydd, ffyrnigrwydd, cronfeydd dŵr amgylcheddol a mewnwelediadau genomig" Llwyddo i amddiffyn 02/10/201513/08/2018
Hydref 2017-Medi 2019 Mr. Daniel Morris (goruchwyliwr sylfaenol ar gyfer MPhil. yn Med Micro) "MYCO WELL D-ONE: A all prawf diagnostig cyflym newydd ar gyfer wraplasma a Mycoplasma ganfod heintiau" Amddiffyn yn llwyddiannus 19/07/2019
Sep. 2012-Medi 2015 Dr. Shatha Ahmed (goruchwyliwr cynradd ar gyfer Ph.D. mewn Iechyd Plant) "Amrywiad ac addasiad Antigenic Ureaplasma i mewn vivo a phwysedd imiwnedd in vitro " Amddiffyn yn llwyddiannus 02/10/2015
Hydref 2012-Hyd 2015 Miss. Rebecca Brown (goruchwyliwr cynradd ar gyfer Ph.D. mewn Iechyd Plant) "Penderfynu tueddiad Mycoplasma i ac osgoi y system imiwnedd gynhenid" Amddiffyn yn llwyddiannus 16/06/2016.
Ionawr 2011-Ionawr 2015 Mrs. Amina Bshina (goruchwyliwr cynradd ar gyfer Ph.D. mewn Iechyd Plant) "Lefelau proteinase niwtrophil mewngellol ac arwyneb celloedd a dosbarthu: newidiadau yn dilyn allyriad a haint microbaidd" Amddiffyn yn llwyddiannus 05/02/2015
Ionawr 2010-Ionawr 2014 Mr Ali Aboklaish (goruchwyliwr cynradd ar gyfer Ph.D. mewn Iechyd Plant) "Pennu'r antigenau Immunodominant o parvum wreaplasma a'u sefydlogrwydd o dan bwysau imiwnolegol" Amddiffynnwyd yn llwyddiannus 01/12/2014.
Hydref 2009-Hyd 2010 Dr. Salima Abdulla (goruchwyliwr cynradd ar gyfer MD mewn Iechyd Plant) "Diffyg Genetig Datblygiadol: Cymharu Proteinase Neutrophil Newyddenedigol Tymor a Chydrannau Ategol Lefelau Perthynas ag Oedolion" Wedi'i amddiffyn yn llwyddiannus 07/12/2012
Hydref 2006-Hydref 2009 Mr Michael Beeton (goruchwyliwr cynradd ar gyfer Ph.D. mewn Iechyd Plant) "Mecanwaith ymwrthedd Macrolide (gwrthfiotig) o wreaplasma ynysig o fabanod cyn-dymor newydd-anedig." Amddiffynwyd yn llwyddiannus 31/03/2010.
Mawrth 2006-Maw 2007 Dr. Phil Davies (cyd-oruchwyliwr ar gyfer MD mewn Iechyd Plant) "Presenoldeb a gweinyddu fferyllol alpha-1-trypsin mewn clefyd pediatreg yr ysgyfaint a ffibrosis systig." Amddiffyn yn llwyddiannus ar 25 Mehefin 2008.
Contact Details
+44 29207 42394
Prif Adeilad yr Ysbyty, Llawr 6ed, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Themâu ymchwil
Arbenigeddau
- ymwrthedd gwrthficrobaidd